Hayashi Shintaro 林信太郎

… Alternative Names

HAYASHI SHINTARO 林信太郎

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Researcher Number	90312876
Other IDs
Affiliation (Current)	2025: 九州大学, 医学研究院, 共同研究員
Affiliation (based on the past Project Information) *help	2016 – 2025: 九州大学, 医学研究院, 共同研究員 2014 – 2015: 九州大学, 医学(系)研究科(研究院), 研究員 2013: 九州大学, 大学病院, 講師
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Basic Section 52020:Neurology-related
Keywords	Principal Investigator ミクログリア / 筋萎縮性側索硬化症 / 診断マーカー / 脳脊髄液 / グリア性炎症 / galectin-3 / カルシウム結合蛋白 / 脊髄前側索 / TDP-43 / カルレチニン … More / ALFoC / グリア性炎症惹起性 / CCL2 / MCP1 / パルブアルブミン / カルビンディン / 培養ミクログリア / 培養実験 / 炎症 / galectin3 / p22 / ガレクチン3 / 動物モデル / ELISA / 血液脳関門 / 髄鞘淡明化 / 脊髄前・側索 / 脳神経疾患 / 遺伝子 / 運動ニューロン変性 / 活性化ミクログリア / macrophage / microglia / osteopontin / p22phox / 単球走化性蛋白1 / 樹状細胞 / 孤発性筋萎縮性側索硬化症 / 運動ニューロン / マクロファージ / 単球走化性蛋白質１ … More Except Principal Investigator 努力肺活量 / 進行速度 / 病態解明 / 筋萎縮性側索硬化症 Less

ALS脊髄における皮質脊髄路以外の前側索変性を基点とした病態解明と治療標的の同定Principal Investigator
- Principal Investigator
  
  林信太郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Elucidation of the pathogenesis and identification of novel therapeutic targets using a new scale assessing the clinical diversity of ALS
- Principal Investigator
  
  小早川優子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Detection of ALS origin with reference to calcium-binding proteins, those generate glial inflammationPrincipal Investigator
- Principal Investigator
  
  林信太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Significance of and treatment against galectin-3 and p22 accompanied with glial inflamation in ALS spinal cordPrincipal Investigator
- Principal Investigator
  
  HAYASHI SHINTARO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
The origin of retrograde motor neuron degeneration elicited by activated microglia in pre- or early-symptomatic spinal cord tissues from human patients with amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  Hayashi Shintaro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Novel therapeutic strategy for amyotrophic lateral sclerosis targeting calretinin and monocyte chemoattractant protein-1Principal Investigator
- Principal Investigator
  
  HAYASHI SHINTARO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Distinct effects among calcium-binding proteins for microglia to produce chemokines associated with the clinical severity of ALS.2023
- Author(s)
  Hayashi S, Yamasaki R, Kira JI, Isobe N.
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 14 Issue: 1 Pages: 69-73
- DOI
  10.1111/cen3.12738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07517
[Journal Article] Calretinin activates microglia to produce CC-motif ligand 2 relevant to clinical severity of ALS2023
- Author(s)
  Hayashi S, Yamasaki R, Kobayakawa Y, et al.
- Journal Title
  
  Amyotroph Lateral Scler Frontotemporal Degener
  
  Volume: 24 Issue: sup1 Pages: 115-127
- DOI
  10.1080/21678421.2023.2260193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07517
[Journal Article] The first evaluation of calretinin in the spinal axons encompassed in anterolateral funiculi outside the cortical tract and cerebrospinal fluids of ALS patients.2022
- Author(s)
  Hayashi S, Yamasaki R, Kobayakawa Y, Kira JI, Isobe N.
- Journal Title
  
  Amyotroph Lateral Scler Frontotemporal Degener
  
  Volume: 23 Issue: sup1 Pages: 101-102
- DOI
  10.1080/21678421.2022.2120682
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07517
[Journal Article] Axonal protein, calretinin, stimulates microglia to produce chemokines associated with clinical severity of ALS2022
- Author(s)
  Shintaro Hayashi, Ryo Yamasaki, Jun-ichi Kira
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07996
[Journal Article] Calcium-binding proteins stimulate microglia to induce pro-inflammatory mediators similar to ALS2021
- Author(s)
  Hayashi S, Yamasaki R, Kira J.
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07996
[Journal Article] Calcium-binding proteins stimulate microglia to induce pro-inflammatory mediators relevant to ALS2020
- Author(s)
  Hayashi S, Yamasaki R, Okamoto K, KIra J.
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07996
[Journal Article] Immunotherapy-refractory vacuolar myopathy with mucin deposition in scleromyxedema: a possible role of fibroblast growth factor 22020
- Author(s)
  Yanagihara Y, Hayashi S, Kira J, et al.
- Journal Title
  
  Neuropathology
  
  Volume: 40 Issue: 5 Pages: 492-495
- DOI
  10.1111/neup.12659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07996
[Journal Article] Discriminative clinical and neuroimaging features of motor-predominant hereditary diffuse leukoencephalopathy with axonal spheroids and primary progressive multiple sclerosis: A preliminary cross-sectional study2019
- Author(s)
  Saitoh B, Yamasaki R, Hiwatashi A, Matsushita T, Hayashi S, Mitsunaga Y, Maeda Y, Isobe N, Yoshida K, Ikeda S, Kira J.
- Journal Title
  
  Multiple Sclerosis and Related Disorders
  
  Volume: 31 Pages: 22-31
- DOI
  10.1016/j.msard.2019.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19K07996, KAKENHI-PROJECT-20K20470
[Journal Article] Microglial galectin-3 in the spinal white matter is a key molecule for motor neuron degeneration in ALS2019
- Author(s)
  Hayashi S, Yamasaki R, Kira JI, et al.
- Journal Title
  
  Amyotroph Lateral Scler Frontotemporal Degener
  
  Volume: 20 Issue: sup1 Pages: 74-75
- DOI
  10.1080/21678421.2019.1646546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07996
[Journal Article] Case of white-eyed shunt carotid-cavernous sinus fistula mimicking optic neuritis2018
- Author(s)
  Hayashi S, Okamoto K, et al.
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 10 Pages: 57-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09721
[Journal Article] Hopkins syndrome following the first episode of bronchial asthma associated with enterovirus D68: a case report2018
- Author(s)
  Hayashi F, Hayashi S, Kira JI, et al.
- Journal Title
  
  BMC Neurol
  
  Volume: 18 Issue: 1
- DOI
  10.1186/s12883-018-1075-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09721
[Journal Article] Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis2018
- Author(s)
  Kobayakawa Yuko、Masaki Katsuhisa、Yamasaki Ryo、Shiraishi Wataru、Hayashida Shotaro、Hayashi Shintaro、Okamoto Koichi、Matsushita Takuya、Kira Jun-ichi
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 12 Pages: 894-894
- DOI
  10.3389/fnins.2018.00894
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09694, KAKENHI-PROJECT-16K09721, KAKENHI-PROJECT-17K19663
[Journal Article] Pathological study of glial inflammation in clinically pre-symptomatic spinal cords in patients with sporadic amyotrophic lateral sclerosis2018
- Author(s)
  Hayashi S, Yamasaki R, Kira JI, et al.
- Journal Title
  
  Amyotroph Lateral Scler Frontotemporal Degener
  
  Volume: 19 Pages: 48-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09721
[Journal Article] Pilocytic astrocytoma with anaplasia arising from the optic chiasm in a very elderly patient.2017
- Author(s)
  Hayashi S, Okamoto K, et al.
- Journal Title
  
  Neurology
  
  Volume: 89 Issue: 17 Pages: 1840-1840
- DOI
  10.1212/wnl.0000000000004575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09721
[Journal Article] Meningeal plasma cell granuloma in the early stage of relapsing polychondritis2017
- Author(s)
  Hayashi S, Okamoto K, et al.
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 57 Issue: 6 Pages: 280-286
- DOI
  10.5692/clinicalneurol.cn-000975
- NAID
  130006882275
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09721
[Journal Article] 胸腺過形成を合併したHTLV-1関連脊髄症の１例2016
- Author(s)
  林信太郎、他
- Journal Title
  
  神経内科
  
  Volume: 84 Pages: 595-599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09721
[Journal Article] Early- and late-activated microglia show distinct localization and exert different impact on TDP-43 pathology in amyotrophic lateral sclerosis spinal cord2016
- Author(s)
  Shintaro Hayashi, Ryo Yamasaki, et al.
- Journal Title
  
  Amyotroph Lateral Scler Frontotemporal Degener
  
  Volume: 17 Issue: sup1 Pages: 70-71
- DOI
  10.1080/21678421.2016.1231971
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K09721
[Journal Article] Morvan's syndrome and myasthenia gravis related to familial mediterranean fever gene mutation2016
- Author(s)
  Junpei Koge , Shintaro Hayashi, et al.
- Journal Title
  
  J Neuroinflammation
  
  Volume: 13 Issue: 1 Pages: 1-4
- DOI
  10.1186/s12974-016-0533-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09721
[Journal Article] A case of severe chronic inflammatory demyelinating polyradiculoneuropathy with monocloncal gammopathy of undetermined significance with alternating immunoglobulin class to IgM from IgA2016
- Author(s)
  Shintaro Hayashi, et al.
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 56 Pages: 593-599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09721
[Journal Article] A case of cerebrotendinous xanthomatosis mimicking the clinical phenotype of mitochondrial disease with a novel mutation (c. 43_44 delGG) in CYP27A1 gene exon.12016
- Author(s)
  Junpei Koge, Shintaro Hayashi, et al.
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 56 Pages: 667-671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09721
[Journal Article] Immune-mediated spastic paraparesis accompanied with high titres of voltage-gated potassium channel complex antibodies and myokimia/fasciculation2016
- Author(s)
  Ban-yu Saitoh, Shintaro Hayashi, et al.
- Journal Title
  
  J Neurol Sci
  
  Volume: 364 Pages: 133-135
- DOI
  10.1016/j.jns.2016.03.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09721
[Journal Article] Ectopic germinoma involving multiple midline and paramedian structures outside the pineal gland or hypophyseal region of the brain prior to tumor development2015
- Author(s)
  Hayashi S, Okamoto K
- Journal Title
  
  J Neurol Sci
  
  Volume: 358 Pages: 512-514
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461317
[Journal Article] A case of chronic progressive motor-dominant multiple mononeuritis associated with primary Sjögren’s syndrome2015
- Author(s)
  Saitoh BY, Hayashi S, Kamada T, Murai H, Omoto M, Kira J
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 55 Issue: 10 Pages: 753-758
- DOI
  10.5692/clinicalneurol.cn-000748
- NAID
  130005103331
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461317
[Journal Article] A case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome presenting with hypertrophic pachymeningitis2015
- Author(s)
  Shiraishi W, Hayashi S, Iwanaga Y, Murai H, Yamamoto A, Kira J
- Journal Title
  
  J Neurol Sci
  
  Volume: 349 Issue: 1-2 Pages: 229-231
- DOI
  10.1016/j.jns.2014.12.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461317
[Journal Article] A case of adult-onset reducing body myopathy presenting a novel clinical feature, asymmetrical involvement of the sternocleidomastoid and trapezius muscles2014
- Author(s)
  Fujii T, Hayashi S, Kawamura N, Higuchi MA, Tsugawa J, Ohyagi Y, Hayashi YK, Nishino I, Kira J
- Journal Title
  
  J Neurol Sci
  
  Volume: 343 Pages: 206-210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461317
[Journal Article] Decreased CCR2 and CD62L expression on peripheral blood classical monocytes in amyotrophic lateral sclerosis2014
- Author(s)
  Yi Wen Cui, Yuji Kawano, Ryo Yamasaki, Nan Shi, Katsuhisa Masaki, Noriko Isobe, Tomomi Yonekawa, Takuya Matsushita, Takahisa Tateishi, Shintaro Hayashi, and Jun-ichi Kira
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-25461317
[Journal Article] Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model.2014
- Author(s)
  Cui Y and Masaki K et al
- Journal Title
  
  J Neuroinflammation
  
  Volume: 11 Issue: 1 Pages: 42-42
- DOI
  10.1186/1742-2094-11-42
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790889, KAKENHI-PLANNED-25117012, KAKENHI-PROJECT-25293204, KAKENHI-PROJECT-25461282, KAKENHI-PROJECT-25461317, KAKENHI-PROJECT-26461295
[Journal Article] Impaired cytoplastic-nuclear transport of hypoxia-inducible factor-1αin amgotrophic lateral sclerosis.2013
- Author(s)
  Kira J et al
- Journal Title
  
  Brain Pathol
  
  Volume: - Issue: 5 Pages: 534-546
- DOI
  10.1111/bpa.12040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659459, KAKENHI-PROJECT-23790997, KAKENHI-PLANNED-25117012, KAKENHI-PROJECT-25461317
[Journal Article] Loss of calretinin- and parvalbumin-immunoreactive axons in anterolateral columns beyond the corticospinal tracts of amyotrophic lateral sclerosis spinal cords2013
- Author(s)
  Shintaro Hayashi, Masakuni Amari, Koichi Okamoto
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 331 Issue: 1-2 Pages: 61-66
- DOI
  10.1016/j.jns.2013.05.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461317
[Presentation] Calretinin activates microglia to produce CC-motif ligand 2 relevant to clinical severity of ALS2023
- Author(s)
  Hayashi S, Yamasaki R, Kobayakawa Y, et al.
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07517
[Presentation] 活性化ミクログリアが産生する蛋白に着目した運動神経細胞変性相関因子の同定と診断バイオマーカーの探求2023
- Author(s)
  林信太郎、山﨑亮、小早川優子、他.
- Organizer
  第35回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07517
[Presentation] Calretinin activates microglia to produce CC-motif ligand 2 relevant to clinical severity of ALS2023
- Author(s)
  Hayashi S, Yamasaki R, Kobayakawa Y, et al.
- Organizer
  34th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07517
[Presentation] The first evaluation of calretinin in the spinal axons and cerebrospinal fluids of ALS patients.2022
- Author(s)
  Hayashi S, Yamasaki R, Kobayakawa Y, Kira JI, Isobe N.
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07517
[Presentation] カルシウム結合蛋白に着目したミクログリアからの筋萎縮性側索硬化症重症度関連ケモカイン放出因子の解明.2022
- Author(s)
  林信太郎、山﨑亮、吉良潤一、磯部紀子.
- Organizer
  第34回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07517
[Presentation] The first evaluation of calretinin in the spinal axons encompassed in anterolateral funiculi outside the cortical tract and cerebrospinal fluids of ALS patients.2022
- Author(s)
  Hayashi S, Yamasaki R, Kobayakawa Y, Kira JI, Isobe N.
- Organizer
  33rd International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07517
[Presentation] 軸索蛋白であるカルレチニンはミクログリアを刺激し ALSの臨床的重症度と相関するケモカインを産生させる2021
- Author(s)
  林信太郎、山﨑亮、吉良潤一
- Organizer
  第33回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07996
[Presentation] Axonal protein, calretinin, stimulates microglia to produce chemokines associated with clinical severity of ALS2021
- Author(s)
  Shintaro Hayashi, Ryo Yamasaki, Jun-ichi Kira
- Organizer
  32nd International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07996
[Presentation] Axonal proteins stimulate microglia to produce pro-inflammatory cytokines relevant to ALS2021
- Author(s)
  林信太郎、山﨑亮、吉良潤一
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07996
[Presentation] カルシウム結合蛋白によるグリア炎症惹起性の検証-筋萎縮性側索硬化症患者の脳脊髄液所見との比較-2020
- Author(s)
  林信太郎、山崎亮、吉良潤一
- Organizer
  第32回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07996
[Presentation] Calcium-binding proteins stimulate microglia to induce proinflammatory mediators relevant to ALS2020
- Author(s)
  Hayashi S, Yamasaki R, Okamoto K, KIra J.
- Organizer
  第61回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07996
[Presentation] Microglial galectin-3 in the spinal white matter is a key molecule for motor neuron degeneration in ALS2019
- Author(s)
  Shintaro Hayashi, Ryo Yamasaki, Koichi Okamoto, Jun-ichi Kira
- Organizer
  30th International symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07996
[Presentation] ALS脊髄白質に出現するgalectin-3陽性ミクログリアはTDP-43病理と正相関する2019
- Author(s)
  林信太郎, 山﨑亮, 岡本幸市，吉良潤一
- Organizer
  第31回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07996
[Presentation] Macrophage galectin-3 in spinal white matter is a key molecule for TDP-43 pathology in ALS2019
- Author(s)
  林信太郎, 山﨑亮, 岡本幸市，吉良潤一
- Organizer
  第60回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07996
[Presentation] 孤発性筋萎縮性側索硬化症の非症候性脊髄と症候性脊髄におけるグリア炎症の免疫病理学的解析2018
- Author(s)
  林信太郎、山﨑亮、吉良潤一、他.
- Organizer
  第30回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09721
[Presentation] Detection of early glial inflammation in pre-symptomatic spinal cords of amyotrophic lateral sclerosis2018
- Author(s)
  Hayashi S, Yamasaki R, Kira JI, et al.
- Organizer
  第59回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09721
[Presentation] Pathological study of glial inflammation in clinically pre-symptomatic spinal cords in patients with sporadic amyotrophic lateral sclerosis2018
- Author(s)
  Hayashi S, Yamasaki R, Kira JI, et al.
- Organizer
  29th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09721
[Presentation] A case of white-eyed shunt carotid-cavernous sinus fistula mimicking optic neuritis2018
- Author(s)
  Hayashi S, Okamoto K, et al.
- Organizer
  11th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09721
[Presentation] 筋萎縮性側索硬化症の脊髄白質では樹状細胞とマクロファージは異なる局在を示す2017
- Author(s)
  林信太郎，他.
- Organizer
  第29回日本神経免疫学会学術集会 (北海道)
- Data Source
  KAKENHI-PROJECT-16K09721
[Presentation] Distinct distribution of activated microglia/macrophages and dendritic cells in the spinal white matter of amyotrophic lateral sclerosis.2017
- Author(s)
  林信太郎，他.
- Organizer
  23th World Congress of Neurology 2017 (Kyoto)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09721
[Presentation] Early- and late-activated microglia show distinct localization and exert different impact on TDP-43 pathology in amyotrophic lateral sclerosis spinal cord (oral communication)2016
- Author(s)
  Shintaro Hayashi, Ryo Yamasaki, et al.
- Organizer
  27th International Symposium on ALS/MND
- Place of Presentation
  The Convention Center Dublin (Ireland)
- Year and Date
  2016-12-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09721
[Presentation] HTLV-1-Associated Myelopathy Accompanied by Thymic Hyperplasia : A Case Report2016
- Author(s)
  Shintaro Hayashi, et al.
- Organizer
  9th Congress of the Pan-Asian Comittee for Treatment and Research in Multiple Sclerosis (PACTRIMS)
- Place of Presentation
  Millenium Hilton Bangkok (Thailand)
- Year and Date
  2016-10-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09721
[Presentation] Early- and late-activated microglia show distinct localizations in amyotrophic lateral sclerosis spinal cord2016
- Author(s)
  林　信太郎、山﨑　亮、他
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター, 神戸ポートピアホテル
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-16K09721
[Presentation] 筋萎縮性側索硬化症の脊髄では活性早期ミクログリアは灰白質に、活性後期ミクログリアは白質に分布する2016
- Author(s)
  林　信太郎、山﨑　亮、他
- Organizer
  第28回日本神経面計学会学術集会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2016-09-30
- Data Source
  KAKENHI-PROJECT-16K09721
[Presentation] A certain morphology of activated microglia, which correlates with TDP-43 pathology in ALS spinal cord2015
- Author(s)
  Shintaro Hayashi, Ryo Yamasaki, Katsuhisa Masaki, Hiroyuki Murai, Koichi Okamoto, Jun-ichi Kira
- Organizer
  26th International Symposium on ALS/MND
- Place of Presentation
  JW Mariott Grand Lakes, Orland (USA)
- Year and Date
  2015-12-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461317
[Presentation] 活性化ミクログリアの形態差と脊髄内局在差がTDP-43病理形成に与える影響の解析2015
- Author(s)
  林信太郎、眞崎勝久、山崎亮、村井弘之、岡本幸市、吉良潤一
- Organizer
  第２７回日本神経免疫学会学術集会
- Place of Presentation
  長良川国際会議場（岐阜）
- Year and Date
  2015-09-15
- Data Source
  KAKENHI-PROJECT-25461317
[Presentation] Impact of activated microglial morphologies on motor neuron degeneration in ALS spinal cord2015
- Author(s)
  Hayashi S, Yamasaki R, Masaki K, Murai H, Okamoto K, Kira J
- Organizer
  第５６回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟）
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-25461317
[Presentation] 孤発性筋萎縮性側索硬化症の脊髄白質に浸潤する免疫細胞群の特徴：免疫組織化学的解析2013
- Author(s)
  林信太郎、眞崎勝久、山崎亮、村井弘之、大八木保政、岡本幸市、吉良潤一
- Organizer
  第25回日本神経免疫学会学術集会
- Place of Presentation
  下関
- Data Source
  KAKENHI-PROJECT-25461317
[Presentation] TDP-43(A315T) tgマウスの脊髄運動ニューロンにおける核細胞質間輸送障害の解析2013
- Author(s)
  長柄祐子、林信太郎、山崎亮、大八木保政、吉良潤一
- Organizer
  第54回日本神経学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461317
[Presentation] グリア性炎症からみた筋萎縮性側索硬化症の脊髄白質変性に関する形態学的検証2013
- Author(s)
  林信太郎、眞崎勝久、崔訳文、長柄祐子、大八木保政、岡本幸市、吉良潤一
- Organizer
  第54回日本神経学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461317
[Presentation] ALSマウスモデルにおける病態進行に伴うコネキシン蛋白群の変動2013
- Author(s)
  崔訳文、眞崎勝久、山崎亮、林信太郎、長柄祐子、河村真実、今村志穂子、佐藤眞也、吉良潤一
- Organizer
  第25回日本神経免疫学会学術集会
- Place of Presentation
  下関
- Data Source
  KAKENHI-PROJECT-25461317
[Presentation] 筋萎縮性側索硬化症におけるグリア性炎症初期像の同定：発症早期組織と末期組織を用いた免疫病理学的検討
- Author(s)
  林信太郎、山崎亮、眞崎勝久、村井弘之、岡本幸市、吉良潤一
- Organizer
  第２６回日本神経免疫学会学術集会
- Place of Presentation
  金沢歌劇座（金沢）
- Year and Date
  2014-09-04 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-25461317
[Presentation] 免疫細胞群からみた孤発性筋萎縮性側索硬化症の脊髄白質変性機序の再検討
- Author(s)
  林信太郎、山崎亮、眞崎勝久、村井弘之、大八木保政、岡本幸市、吉良潤一
- Organizer
  第５５回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461317
[Presentation] Morphological evidences of glial inflammation that confer spinal white matter degeneration of sporadic amyotrophic lateral sclerosis
- Author(s)
  Hayashi S, Yamasaki R, Masaki K, Murai H, Okamoto K, Kira J
- Organizer
  25th International symposium on ALS-MND
- Place of Presentation
  ブリュッセル (ベルギー)
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-25461317

1. 山崎亮 (10467946)

# of Collaborated Projects: 4 results

# of Collaborated Products: 30 results
2. 小早川優子 (40733788)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
3. OHYAGI YASUMASA (30301336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. TATEISHI TAKAHISA (50423546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. KAWAMURA NOBUTOSHI (00432930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. MATSUSHITA Takuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 吉良潤一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 磯部紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 真崎勝久

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Hayashi Shintaro 林 信太郎

HAYASHI SHINTARO 林 信太郎

Research Projects

Research Products

Co-Researchers

ALS脊髄における皮質脊髄路以外の前側索変性を基点とした病態解明と治療標的の同定Principal Investigator

Principal Investigator

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Elucidation of the pathogenesis and identification of novel therapeutic targets using a new scale assessing the clinical diversity of ALS

Principal Investigator

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Review Section

Research Institution

Detection of ALS origin with reference to calcium-binding proteins, those generate glial inflammationPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Significance of and treatment against galectin-3 and p22 accompanied with glial inflamation in ALS spinal cordPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

The origin of retrograde motor neuron degeneration elicited by activated microglia in pre- or early-symptomatic spinal cord tissues from human patients with amyotrophic lateral sclerosisPrincipal Investigator

Principal Investigator

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Research Institution

Novel therapeutic strategy for amyotrophic lateral sclerosis targeting calretinin and monocyte chemoattractant protein-1Principal Investigator

Principal Investigator

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Research Institution

[Journal Article] Distinct effects among calcium-binding proteins for microglia to produce chemokines associated with the clinical severity of ALS.2023

Author(s)

Journal Title

DOI

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[Journal Article] Calretinin activates microglia to produce CC-motif ligand 2 relevant to clinical severity of ALS2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The first evaluation of calretinin in the spinal axons encompassed in anterolateral funiculi outside the cortical tract and cerebrospinal fluids of ALS patients.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Axonal protein, calretinin, stimulates microglia to produce chemokines associated with clinical severity of ALS2022

Author(s)

Journal Title

Data Source

[Journal Article] Calcium-binding proteins stimulate microglia to induce pro-inflammatory mediators similar to ALS2021

Author(s)

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[Journal Article] Calcium-binding proteins stimulate microglia to induce pro-inflammatory mediators relevant to ALS2020

Author(s)

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[Journal Article] Immunotherapy-refractory vacuolar myopathy with mucin deposition in scleromyxedema: a possible role of fibroblast growth factor 22020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discriminative clinical and neuroimaging features of motor-predominant hereditary diffuse leukoencephalopathy with axonal spheroids and primary progressive multiple sclerosis: A preliminary cross-sectional study2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microglial galectin-3 in the spinal white matter is a key molecule for motor neuron degeneration in ALS2019

Author(s)

Hayashi Shintaro 林信太郎

HAYASHI SHINTARO 林信太郎