Osato Motomi 大里元美

… Alternative Names

大里元美オオサトモトミ

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Researcher Number	90314286
Other IDs
Affiliation (Current)	2022: 熊本大学, 国際先端医学研究機構, 特定研究員
Affiliation (based on the past Project Information) *help	2019 – 2022: 熊本大学, 国際先端医学研究機構, 客員教授 2015 – 2019: 熊本大学, 国際先端医学研究機構, 特別招聘教授 1999: 京都大学, ウイルス研究所, 助手
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor therapeutics / Tumor biology Except Principal Investigator Tumor biology / Complex Systems Disease Theory
Keywords	Principal Investigator 癌 / 白血病 / トランスレーショナルリサーチ / 内科 / RUNX / 分子標的治療 / 細胞不死化 / EBウイルス / スーパーエンハンサー / RUNX転写因子 … More / 抗体医薬 / ITGA9 / AYA世代がん / 分指標的治療 / マウスモデル … More Except Principal Investigator 転写因子 / PEBP2 / AML1 / 白血病 / 点変異 / Runtドメイン / NMR / 立体構造 / 白血病幹細胞 / 15-PGDH / MEIS1 / HOX / MLL / ダウン症 / 血管内皮細胞 / コレステロール代謝 / 血管新生 / 角膜混濁 / DSCR-1 / NFAT / 動脈硬化 / エピゲノム / ヒストン制御 / bivalent / PTIP / non-canonical PRC1 / 肝細胞 / iPS 細胞 / NAFLD / SREBP2 / 血管病変 / 複合疾病 / ダウン症モデルマウス / 脳神経と血管相互作用 / クロマチン動態 / がん微小環境 / 血管病 / 染色体構造と機能 / 新規モデルマウス構築 / Hi-C 解析 / 脳神経と血管の相互作用 / 行動実験 / ダウン症モデル / クロマチン相互作用 / 異数性 / 造血幹細胞老化 Less

Elucidation of the molecular basis for age-dependent leukemogenesis towards a novel therapeutic strategyPrincipal Investigator
- Principal Investigator
  
  大里元美
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University
Development of novel antibodies against leukemia and elucidation of their blocking mechanismsPrincipal Investigator
- Principal Investigator
  
  大里元美
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University
multi-pathogenesis aging research based on the Down syndrome aneuploidy model
- Principal Investigator
  
  MINAMI Takashi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Complex Systems Disease Theory
- Research Institution
  Kumamoto University
15-PGDH regulates leukemia stem cell potential in HOX-associated myeloid leukemia
- Principal Investigator
  
  Iwasaki Masayuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tokyo Women's Medical University
  Kumamoto University
Superenhancer-mediated RUNX3 overexpression in EB virus-associated tumorigenesisPrincipal Investigator
- Principal Investigator
  
  Osato Motomi
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Kumamoto University
Development of a novel therapeutic method against acute megakaryoblastic leukemia by NOTCH agonistsPrincipal Investigator
- Principal Investigator
  
  Osato Motomi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kumamoto University
転写因子のPEBP2α/AML1の点変異による機能変化とその発癌能
- Principal Investigator
  
  重定勝哉
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach2022
- Author(s)
  Douchi Daisuke、Yamamura Akihiro、Matsuo Junichi、Nuttonmanit Napat、Shimura Mitsuhiro、Pang ShuChin、Kohu Kazuyoshi、Kaneko Mari、Kiyonari Hiroshi、Kaneda Atsushi、Taniuchi Ichiro、Osato Motomi、Yang Henry、Unno Michiaki、Bok-Yan So Jimmy、Yeoh Khay Guan、Huey Chuang Linda Shyue、Bae Suk-Chul、Ito Yoshiaki
- Journal Title
  
  Cell Mol Gastroenterol Hepatol
  
  Volume: 13 Pages: 1317-1345
- DOI
  10.1016/j.jcmgh.2022.01.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05747, KAKENHI-PROJECT-19H03726, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-21K20822
[Journal Article] Trib1 promotes the development of acute myeloid leukemia in a Ts1Cje mouse model of Down syndrome.2022
- Author(s)
  Yoshino Seiko、Tanaka Miwa、Sunami Yoshitaka、Takahara Tomoko、Yamazaki Yukari、Homme Mizuki、Niibori-Nambu Akiko、Osato Motomi、Minami Takashi、Ishihara Keiichi、Nakamura Takuro
- Journal Title
  
  Leukemia
  
  Volume: 36 Pages: 558-561
- DOI
  10.1038/s41375-021-01384-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KT0026, KAKENHI-PROJECT-19K07702, KAKENHI-PROJECT-20K16318, KAKENHI-PROJECT-20K17389, KAKENHI-PUBLICLY-20H05521, KAKENHI-PROJECT-19H01035, KAKENHI-PROJECT-21H02917, KAKENHI-PROJECT-17K07199, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-18KK0440
[Journal Article] The acidic domain of Hmga2 and the domain's linker region are critical for driving self-renewal of hematopoietic stem cell.2022
- Author(s)
  Sun Yuqi、Kubota Sho、Iimori Mihoko、Hamashima Ai、Murakami Haruka、Bai Jie、Morii Mariko、Yokomizo-Nakano Takako、Osato Motomi、Araki Kimi、Sashida Goro
- Journal Title
  
  Int J Hematol
  
  Volume: 115 Pages: 553-562
- DOI
  10.1007/s12185-021-03274-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02391, KAKENHI-PROJECT-21H02952, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-21K08421, KAKENHI-PROJECT-21K19512
[Journal Article] RUNX1-ETO (RUNX1-RUNX1T1) induces myeloid leukemia in mice in an age-dependent manner.2021
- Author(s)
  Abdallah, M. G., Niibori-Nambu, A., Morii, M., Yokomizo, T., Yokomizo, T., Ideue, T., Kubota, S., Teoh, V. S. I., Mok, M. M. H., Wang, C. Q., Omar, A. A., Tokunaga, K., Iwanaga, E., Matsuoka, M., Asou, N., Nakagata, N., Araki, K., AboElenin, M., Madboly, S. H., Sashida, G. and Osato, M.
- Journal Title
  
  Leukemia
  
  Volume: 35 Pages: 2983-2988
- DOI
  10.1038/s41375-021-01268-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02391, KAKENHI-PROJECT-21H02952, KAKENHI-PROJECT-19J40166, KAKENHI-PROJECT-17K07199, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-20K08758, KAKENHI-PROJECT-21K19512, KAKENHI-PROJECT-18KK0440
[Journal Article] ZNF143 mediates CTCF-bound promoter enhancer loops required for murine hematopoietic stem and progenitor cell function2021
- Author(s)
  Zhou Qiling、Yu Miao、Tirado-Magallanes Roberto、Li Bin、Kong Lingshi、Guo Mingrui、Tan Zi Hui、Lee Sanghoon、Chai Li、Numata Akihiko、Benoukraf Touati、Fullwood Melissa Jane、Osato Motomi、Ren Bing、Tenen Daniel G.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Pages: 43-43
- DOI
  10.1038/s41467-020-20282-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-18K08362
[Journal Article] Tocilizumab Induces IL-10-Mediated Immune Tolerance in Invasive Candidiasis.2021
- Author(s)
  Tan Z, Mok MMH, Mar Soe W, Thamboo TP, Goh JG, Sam QH, Osato M, Ravikumar S, Chai LYA.
- Journal Title
  
  J Fungi (Basel)
  
  Volume: 7 Pages: 656-656
- DOI
  10.3390/jof7080656
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668
[Journal Article] Super-enhancers for RUNX3 are required for cell proliferation in EBV-infected B cell lines.2021
- Author(s)
  Hosoi Hiroki、Niibori-Nambu Akiko、Nah Giselle Sek Suan、Bahirvani Avinash Govind、Mok Michelle Meng Huang、Sanda Takaomi、Kumar Alan Prem、Tenen Daniel G.、Ito Yoshiaki、Sonoki Takashi、Osato Motomi
- Journal Title
  
  Gene
  
  Volume: 774 Pages: 145421-145421
- DOI
  10.1016/j.gene.2021.145421
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07199, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-19K08821, KAKENHI-PROJECT-18KK0440, KAKENHI-PROJECT-19K17839
[Journal Article] Familial leukemia due to germline RUNX1 mutations: lessons learned from two decades of research and unsolved problems2020
- Author(s)
 大里元美、南部晶子
- Journal Title
 
 Jpn. J. Clin. Hematol.
 
 Volume: 61 Issue: 6 Pages: 687-696
- DOI
 10.11406/rinketsu.61.687
- NAID
 130007869120
- ISSN
 0485-1439, 1882-0824
- Language
 Japanese
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-19K07668
[Journal Article] Overexpression of RUNX3 represses RUNX1 to drive transformation of myelodysplastic syndrome.2020
- Author(s)
  Yokomizo-Nakano T, Kubota S, Bai J, Hamashima A, Morii M, Sun Y, Katagiri S, Iimori M, Kanai A, Tanaka D, Oshima M, Harada Y, Ohyashiki K, Iwama A, Harada H, Osato M, Sashida G.
- Journal Title
  
  Cancer Research
  
  Volume: Epub
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668
[Journal Article] TUBB1 dysfunction identified in familial platelet disorder causes impaired proplatelet formation and genome instability2020
- Author(s)
  Matsumura T, Nakamura-Ishizu A, Maki H, Takaoka K, Muddineni SSNA, Wang CQ, Suzushima H, Kawakita M, Asou N, Matsuoka M, Kurokawa M, Osato M, Suda T
- Journal Title
  
  Developmental Biology,
  
  Volume: 0 Pages: 0-0
- DOI
  10.1111/bjh.15835
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-18H04052
[Journal Article] Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia2020
- Author(s)
  Matsumura Takayoshi、Nakamura-Ishizu Ayako、Muddineni Siva Sai Naga Anurag、Tan Darren Qiancheng、Wang Chelsia Qiuxia、Tokunaga Kenji、Tirado-Magallanes Roberto、Sian Stephanie、Benoukraf Touati、Okuda Tsukasa、Asou Norio、Matsuoka Masao、Osato Motomi、Suda Toshio
- Journal Title
  
  Blood
  
  Volume: 136 Pages: 1919-1932
- DOI
  10.1182/blood.2019004292
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-19K08846, KAKENHI-PROJECT-18H05284
[Journal Article] The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells.2020
- Author(s)
  Chuang LSH, Osato M, Ito Y.
- Journal Title
  
  Molecules and Cells
  
  Volume: 43 Pages: 121-125
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668
[Journal Article] A two-pronged anti-leukemic agent based on a hyaluronic acid green tea catechin conjugate for inducing targeted cell death and terminal differentiation2020
- Author(s)
  Liang Kun、Bae Ki Hyun、Nambu Akiko、Dutta Bibek、Chung Joo Eun、Osato Motomi、Kurisawa Motoichi
- Journal Title
  
  Biomaterials Science
  
  Volume: 8 Pages: 497-505
- DOI
  10.1039/c9bm01146c
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-18KK0440
[Journal Article] Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance2020
- Author(s)
  Numata A、Kwok HS、Zhou QL、Li J、Tirado-Magallanes R、Angarica Vladimir VE、Hannah R、Park J、Wang CQ、Krishnan V、Rajagopalan D、Zhang Y、Zhou S、Welner RS.、Osato M、Jha S、Bohlander SK.、Goettgens B、Yang H、Benoukraf T、Lough JW.、Bararia D、Tenen DG.
- Journal Title
  
  Blood
  
  Volume: 136 Pages: 1735-1747
- DOI
  10.1182/blood.2019001279
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-18K08362
[Journal Article] Low prevalence of the BCR?ABL1 fusion gene in a normal population in southern Sarawak2020
- Author(s)
  Kuan JW, Su AT, Tay SP, Fong IL, Kubota S, Su'ut L, Osato M, Sashida G.
- Journal Title
  
  Int J Hematol.
  
  Volume: 111 Pages: 217-224
- DOI
  10.1007/s12185-019-02768-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-17J02389
[Journal Article] Lineage-specific RUNX2 super-enhancer activates MYC via a chromosomal translocation and promotes the development of blastic plasmacytoid dendritic cell neoplasm2019
- Author(s)
  Kubota S, Tokunaga K, Umezu T, Yokomizo-Nakano T, Oshima M, Tan KT, Yang H, Kanai A. Iwanaga E, Asou N, Maeda T, Nakagata N. Ito T, Iwama A. Ohyashiki K, Osato M, Sashida G.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 10 Issue: 1 Pages: 1653-1653
- DOI
  10.1038/s41467-019-09710-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18K07244, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-17J02389
[Journal Article] Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors2019
- Author(s)
  Tomomasa Yokomizo, Naoki Watanabe, Terumasa Umemoto, Junichi Matsuo, Ryota Harai, Yoshihiko Kihara, Eri Nakamura, Norihiro Tada, Tomohiko Sato, Tomoiku Takaku, Akihiko Shimono, Hitoshi Takizawa, Naomi Nakagata, Seiichi Mori, Mineo Kurokawa, Daniel Tenen, Motomi Osato, Toshio Suda, and Norio Komatsu.
- Journal Title
  
  The Journal of Experimental Medicine
  
  Volume: 216 Pages: 1599-1614
- DOI
  10.1084/jem.20181399
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05691, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-19K22641, KAKENHI-PROJECT-18K16127, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-18H04052, KAKENHI-PROJECT-19H03688, KAKENHI-PROJECT-17K09958
[Journal Article] EVI1 triggers metabolic reprogramming associated with leukemogenesis and increases sensitivity to L-asparaginase2019
- Author(s)
  Saito Yusuke、Sawa Daisuke、Kinoshita Mariko、Yamada Ai、Kamimura Sachiyo、Suekane Akira、Ogoh Honami、Matsuo Hidemasa、Adachi Souichi、Taga Takashi、Tomizawa Daisuke、Osato Motomi、Soga Tomoyoshi、Morishita Kazuhiro、Moritake Hiroshi
- Journal Title
  
  Haematologica
  
  Volume: Epub
- DOI
  10.3324/haematol.2019.225953
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-19K16832
[Journal Article] Systematic Review of Normal Subjects Harbouring BCR-ABL1 Fusion Gene2019
- Author(s)
 Kuan JW, Su AT, Leong CF, Osato M, Sashida G.
- Journal Title
 
 Acta Haematologica
 
 Volume: 143 Pages: 96-111
- DOI
 10.1159/000501146
- Peer Reviewed / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-19K07668
[Journal Article] Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy2019
- Author(s)
  Khattar E, Maung KZY, Chew CL, Ghosh A, Mok MMH, Lee P, Zhang J, Chor WHJ, Cildir G, Wang CQ, Mohd-Ismail NK, Chin DWL, Lee SC, Yang H, Shin YJ, Nam DH, Chen L, Kumar AP, Deng LW, Ikawa M, Gunaratne J, Osato M, Tergaonkar V.
- Journal Title
  
  Nature Communications
  
  Volume: 10 Pages: 5349-5349
- DOI
  10.1038/s41467-019-13082-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668, KAKENHI-ORGANIZER-19H05749
[Journal Article] ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia2019
- Author(s)
  Zhou Jianbiao、Quah Jessie Yiying、Ng Yvonne、Chooi Jing-Yuan、Toh Sabrina Hui-Min、Lin Baohong、Tan Tuan Zea、Hosoi Hiroki、Osato Motomi、Seet Qihui、Ooi A.G. Lisa、Lindmark Bertil、McHale Mark、Chng Wee-Joo
- Journal Title
  
  Haematologica
  
  Volume: Epub
- DOI
  10.3324/haematol.2019.230482
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668
[Journal Article] Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia2017
- Author(s)
  Liau WS, Tan SH, Ngoc PC, Wang CQ, Tergaonkar V, Feng H, Gong Z, Osato M, Look AT, Sanda T.
- Journal Title
  
  Leukemia
  
  Volume: 印刷中 Pages: 1798-1807
- DOI
  10.1038/leu.2016.392
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312, KAKENHI-PROJECT-16K14613
[Journal Article] A DNA Contact Map for the Mouse Runx1 Gene Identifies Novel Haematopoietic Enhancers2017
- Author(s)
  Marsman Judith、Thomas Amarni、Osato Motomi、O’Sullivan Justin M.、Horsfield Julia A.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 13347-13347
- DOI
  10.1038/s41598-017-13748-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Journal Article] Activation of EVI1 transcription by the LEF1/β-catenin complex with p53-alteration in myeloid blast crisis of chronic myeloid leukemia2017
- Author(s)
  Manachai N, Saito Y, Nakahata S, Bahirvani AG, Osato M, Morishita K.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 482 Pages: 994-1000
- DOI
  10.1016/j.bbrc.2016.11.146
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312, KAKENHI-PROJECT-16K14613
[Journal Article] LIN28B Activation by PRL-3 Promotes Leukemogenesis and a Stem Cell-like Transcriptional Program in AML2017
- Author(s)
  Zhou J, Chan ZL, Bi C, Lu X, Chong PS, Chooi JY, Cheong LL, Liu SC, Ching YQ, Zhou Y, Osato M, Tan TZ, Ng CH, Ng SB, Wang S, Zeng Q, Chng WJ.
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 15 Pages: 294-303
- DOI
  10.1158/1541-7786.mcr-16-0275-t
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312, KAKENHI-PROJECT-16K14613
[Journal Article] Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice2017
- Author(s)
  Matsuo J, Kimura S, Yamamura A, Koh CP, Hossain MZ, Heng DL, Kohu K, Voon DC, Hiai H, Unno M, So JB, Zhu F, Srivastava S, Teh M, Yeoh KG, Osato M, Ito Y.
- Journal Title
  
  Gastroenterology
  
  Volume: 152 Pages: 218-231
- DOI
  10.1053/j.gastro.2016.09.018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312, KAKENHI-PROJECT-16K14613
[Journal Article] RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC2017
- Author(s)
  Selvarajan V, Osato M, Nah GS, Yan J, Chung TH, Voon DC, Ito Y, Ham MF, Salto-Tellez M, Shimizu N, Choo SN, Fan S, Chng WJ, Ng SB.
- Journal Title
  
  Leukemia
  
  Volume: 印刷中 Pages: 2219-2227
- DOI
  10.1038/leu.2017.40
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312, KAKENHI-PROJECT-16K14613
[Journal Article] Ikk2 regulates cytokinesis during vertebrate development2017
- Author(s)
  Shen Hongyuan、Shin Eun Myoung、Lee Serene、Mathavan Sinnakaruppan、Koh Hiromi、Osato Motomi、Choi Hyungwon、Tergaonkar Vinay、Korzh Vladimir
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 8094-8094
- DOI
  10.1038/s41598-017-06904-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Journal Article] Runx Family Genes in Tissue Stem Cell Dynamics2017
- Author(s)
  Wang CQ, Mok MM, Yokomizo T, Tergaonkar V, Osato M.
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 962 Pages: 117-138
- DOI
  10.1007/978-981-10-3233-2_9
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312, KAKENHI-PROJECT-26461454, KAKENHI-PROJECT-16K14613
[Journal Article] In Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos , and Gata2 Overexpression within Teratoma2017
- Author(s)
  Tsukada Masao、Ota Yasunori、Wilkinson Adam C.、Becker Hans J.、Osato Motomi、Nakauchi Hiromitsu、Yamazaki Satoshi
- Journal Title
  
  Stem Cell Reports
  
  Volume: 9 Pages: 1024-1033
- DOI
  10.1016/j.stemcr.2017.08.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02661, KAKENHI-PROJECT-15H04312, KAKENHI-PROJECT-17H05086
[Journal Article] RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.2016
- Author(s)
  Chin DW, Sakurai M, Nah GS, Du L, Jacob B, Yokomizo T, Matsumura T, Suda T, Huang G, Fu XY, Ito Y, Nakajima H, Osato M.
- Journal Title
  
  Blood Cancer J.
  
  Volume: 6
- DOI
  10.1038/bcj.2015.105
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461454, KAKENHI-PROJECT-15H04312
[Journal Article] Cyclin A2 regulates erythrocyte morphology and numbers.2016
- Author(s)
  Jayapal SR, Ang HY, Wang CQ, Bisteau X, Caldez MJ, Xuan GX, Yu W, Tergaonkar V, Osato M, Lim B, Kaldis P.
- Journal Title
  
  Cell Cycle
  
  Volume: 15 Pages: 3070-3081
- DOI
  10.1080/15384101.2016.1234546
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312, KAKENHI-PROJECT-16K14613
[Journal Article] Lack of Phenotypical and Morphological Evidences of Endothelial to Hematopoietic Transition in the Murine Embryonic Head during Hematopoietic Stem Cell Emergence2016
- Author(s)
  Iizuka K, Yokomizo T, Watanabe N, Tanaka Y, Osato M, Takaku T, Komatsu N.
- Journal Title
  
  PLoS One
  
  Volume: 11
- DOI
  10.1371/journal.pone.0156427
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04312, KAKENHI-PROJECT-26461454, KAKENHI-PROJECT-16K14613
[Journal Article] Cbfb deficiency results in differentiation blocks and stem/progenitor cell expansion in hematopoiesis.2015
- Author(s)
  Wang CQ, Chin DW, Chooi JY, Wee Joo C, Taniuchi I, Tergaonkar V, Osato M.
- Journal Title
  
  Leukemia
  
  Volume: 29 Pages: 753-7
- DOI
  10.1038/leu.2014.316
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-26114720, KAKENHI-PROJECT-26293109, KAKENHI-PROJECT-15H04312
[Journal Article] Mouse models for core binding factor leukemia.2015
- Author(s)
  Chin DW, Watanabe-Okochi N, Wang CQ, Tergaonkar V, Osato M.
- Journal Title
  
  Leukemia
  
  Volume: 29 Pages: 1970-80
- DOI
  10.1038/leu.2015.181
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Journal Article] MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis.2015
- Author(s)
  Koh CM, Bezzi M, Low DH, Ang WX, Teo SX, Gay FP, Al-Haddawi M, Tan SY, Osato M, Sabò A, Amati B, Wee KB, Guccione E.
- Journal Title
  
  Nature
  
  Volume: 523 Pages: 96-100
- DOI
  10.1038/nature14351
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Journal Article] Hematopoietic stem cell enhancer: a powerful tool in stem cell biology.2015
- Author(s)
  Koh CP, Ng CE, Nah GS, Wang CQ, Tergaonkar V, Matsumura T, Yokomizo T, Suda T, Osato M.
- Journal Title
  
  Histol Histopathol
  
  Volume: 30 Pages: 661-72
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Journal Article] The artificial loss of Runx1 reduces the expression of quiescence-associated transcription factors in CD4(+) T lymphocytes2015
- Author(s)
  Wong WF, Kohu K, Nagashima T, Funayama R, Matsumoto M, Movahed E, Tan GM, Yeow TC, Looi CY, Kurokawa M, Osato M, Igarashi K, Nakayama K, Satake M.
- Journal Title
  
  Mol Immunol
  
  Volume: 68 Pages: 223-233
- DOI
  10.1016/j.molimm.2015.08.012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312, KAKENHI-PROJECT-15K15024, KAKENHI-PROJECT-26830064, KAKENHI-PROJECT-26293059
[Journal Article] DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis.2015
- Author(s)
  Png CW, Weerasooriya M, Guo J, James SJ, Poh HM, Osato M, Flavell RA, Dong C, Yang H, Zhang Y.
- Journal Title
  
  Oncogene
  
  Volume: 35 Pages: 206-17
- DOI
  10.1038/onc.2015.74
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Journal Article] Bimodal Influence of Vitamin D in Host Response to Systemic Candida Infection-Vitamin D Dose Matters.2015
- Author(s)
  Lim JH, Ravikumar S, Wang YM, Thamboo TP, Ong L, Chen J, Goh JG, Tay SH, Chengchen L, Win MS, Leong W, Lau T, Foo R, Mirza H, Tan KS, Sethi S, Khoo AL, Chng WJ, Osato M, Netea MG, Wang Y, Chai LY.
- Journal Title
  
  J Infect Dis
  
  Volume: 212 Pages: 635-44
- DOI
  10.1093/infdis/jiv033
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Journal Article] Hematopoiesis specific loss of Cdk2 and Cdk4 results in increased erythrocyte size and delayed platelet recovery following stress.2015
- Author(s)
  Jayapal SR, Wang CQ, Bisteau X, Caldez MJ, Lim S, Tergaonkar V, Osato M, Kaldis P.
- Journal Title
  
  Haematologica
  
  Volume: 100 Pages: 431-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] RUNX1-ETO induces myeloid leukemia in mice in an age-dependent manner.2021
- Author(s)
  Osato M
- Organizer
  the 39th Sapporo International Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668
[Presentation] t(8:21)白血病研究の新展開：マウスモデルの確立と新規治療戦略の構築2021
- Author(s)
  大里元美
- Organizer
  第25回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-19K07668
[Presentation] Familial leukemia due to germline RUNX1 mutations: Lessons from two decades of research, and unsolved questions.2021
- Author(s)
  Osato M
- Organizer
  Cancer Genomics Haematol Disord Conf, Newcastle Univ Med Malaysia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668
[Presentation] Lessons from two decades of research on germ line RUNX1 mutations2019
- Author(s)
  Motomi Osato
- Organizer
  第81回日本血液学会学術集会、東京
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668
[Presentation] Activation of Notch signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia2019
- Author(s)
  Motomi Osato
- Organizer
  第78回日本癌学会学術総会、京都
- Data Source
  KAKENHI-PROJECT-19K07668
[Presentation] Integrin a9 overexpression synergizes with RUNX alteration in leukemogenesis2019
- Author(s)
  Motomi Osato
- Organizer
  22nd International RUNX Conference 2019, Seoul, Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07668
[Presentation] ダウン症関連急性巨核芽球性白血病に対する新規治療・予防法2019
- Author(s)
  Motomi Osato
- Organizer
  第１回ダウン症基礎研究会、大阪
- Data Source
  KAKENHI-PROJECT-19K07668
[Presentation] Hematological abnormalities in Down syndrome: segmental aging in blood2019
- Author(s)
  Motomi Osato
- Organizer
  第42 回日本分子生物学会年会、福岡
- Data Source
  KAKENHI-PROJECT-19K07668
[Presentation] Hlf marks nascent HSCs, but not EMPs.2018
- Author(s)
  Osato M
- Organizer
  JSPS & NUS Joint 2nd Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] Enhancer for Runx1, eR1: a powerful tool in stem cell and cancer biology2018
- Author(s)
  大里元美
- Organizer
  平成29年度先端モデル動物支援プラットフォーム成果発表会
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] 急性巨核芽球性白血病に対する新規治療法2018
- Author(s)
  大里元美
- Organizer
  第22回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] RUNX2 superenhancer-driven MYC activation causes blastic plasmacytoid dendritic cell neoplasm.2017
- Author(s)
  大里元美
- Organizer
  第21回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] A novel treatment and prevention for acute megakaryoblastic leukemia in Singapore and Malaysia2017
- Author(s)
  Osato M
- Organizer
  AIMST International Conference on Non-Communicable Diseases
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] スフィンゴシン１リン酸S1Pによるリガンド非依存性NOTCH活性化を介した白血病治療2017
- Author(s)
  大里元美
- Organizer
  第12回スフィンゴテラピィ研究会
- Invited
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] RUNX3エンハンサーeR3による腸上皮細胞間リンパ球の抗腫瘍効果制御機構2017
- Author(s)
  Osato M
- Organizer
  Cancer Research Institute of Kanazawa University symposium
- Place of Presentation
  Kanazawa, Japan
- Year and Date
  2017-02-14
- Invited
- Data Source
  KAKENHI-PROJECT-16K14613
[Presentation] RUNX3エンハンサーeR3による腸上皮細胞間リンパ球の抗腫瘍効果制御機構2017
- Author(s)
  Osato M
- Organizer
  Cancer Research Institute of Kanazawa University symposium
- Place of Presentation
  Kanazawa, Japan
- Year and Date
  2017-02-14
- Invited
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] Enancer for Runx1, eR1: a powerful tool in stem cell and cancer biology2017
- Author(s)
  Osato M
- Organizer
  21st International RUNX Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] Enhancer for Runx1, eR1: a powerful tool in stem cell and cancer biology2016
- Author(s)
  Osato M
- Organizer
  14th Stem Cell Res Symposium
- Place of Presentation
  Awaji, Japan
- Year and Date
  2016-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14613
[Presentation] Enhancer for Runx1, eR1: a powerful tool in stem cell biology2016
- Author(s)
  Osato M
- Organizer
  JSPS-NUS Joint Symposium
- Place of Presentation
  Singapore (Singapore)
- Year and Date
  2016-01-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] Enhancer for Runx1, eR1: a powerful tool in stem cell and cancer biology2016
- Author(s)
  Osato M
- Organizer
  39th Annual Mtg of Molecular Biology Society of Japan
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2016-11-30
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] Whole-mount three-dimensional analysis of hematopoietic development in the mouse embryonic head2016
- Author(s)
  Yokomizo T, Iizuka K, Osato M, Takaku T, Komatsu N
- Organizer
  JSPS-NUS Joint Symposium
- Place of Presentation
  Singapore (Singapore)
- Year and Date
  2016-01-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] Enhancer for Runx1, eR1: a powerful tool in stem cell and cancer biology2016
- Author(s)
  Osato M
- Organizer
  39th Annual Mtg of Molecular Biology Society of Japan
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2016-11-30
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14613
[Presentation] Enhancer for Runx1, eR1: a powerful tool in stem cell and cancer biology2016
- Author(s)
  Osato M
- Organizer
  14th Stem Cell Res Symposium
- Place of Presentation
  Awaji, Japan
- Year and Date
  2016-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells2015
- Author(s)
  Osato M
- Organizer
  14th Asian Conference on Transcription
- Place of Presentation
  Singapore (Singapore)
- Year and Date
  2015-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] Intraepithelial Lymphocytes against Gastrointestinal Cancer2015
- Author(s)
  Osato M
- Organizer
  Singapore Gastric Cancer Consortium’s 8th Annual Scientific Meeting
- Place of Presentation
  Singapore (Singapore)
- Year and Date
  2015-07-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] An Upstream RUNX3 Enhancer Regulates the Development of Gut-Associated Anti-Tumorigenic CD8+CD103+ Cytotoxic T Lymphocytes2015
- Author(s)
  Osato M
- Organizer
  20th Runx meeting
- Place of Presentation
  Rehovot(Israel)
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal and adult hematopoietic stem cells2015
- Author(s)
  Osato M, Koh CP, Yokomizo T
- Organizer
  13th Stem Cell Research Symposium
- Place of Presentation
  University of Tokyo (Tokyo, Japan)
- Year and Date
  2015-05-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] Enhancer for Runx1, eR1: a powerful tool in stem cell and cancer biology2015
- Author(s)
  Osato M
- Organizer
  Frontiers in Cancer Science 2015
- Place of Presentation
  Singapore (Singapore)
- Year and Date
  2015-11-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312
[Presentation] Disruption of Runx1 and Runx3 Leads to Bone Marrow Failure and Leukemia Predisposition due to Transcriptional and DNA Repair Defects.2015
- Author(s)
  Osato M
- Organizer
  6th JSH International Symposium
- Place of Presentation
  Karuizawa Prince Hotel (Nagano, Japan)
- Year and Date
  2015-05-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04312

1. Iwasaki Masayuki (70790913)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 指田吾郎 (70349447)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. MINAMI Takashi (00345141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 重定勝哉 (40009626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 横溝智雅 (80590314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. 山本浩平 (50451927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 倉林伸博 (40581658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. UMEZU Tomohiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. NANBU Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. KANEDA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. TANAKA Miwa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. ISHIHARA Keiichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. TAKAO Keizo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. IIZUKA Kazuhide

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 谷内一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 久保田翔

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
17. 金井昭教

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 荒木正健

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 荒木喜美

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 荒木令江

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 中山啓子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 舟山亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 長嶋剛史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 多田昇弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 梅本晃正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 木原慶彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 須田年生

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
28. 黒川峰夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
29. 沼田晃彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
30. 芳野聖子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 角南義孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 中村卓郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. 松尾英将

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 奥田司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 園木孝志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 細井裕樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 中内啓光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 山崎聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 伊川正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Osato Motomi 大里 元美

大里 元美 オオサト モトミ

Research Projects

Research Products

Co-Researchers

Elucidation of the molecular basis for age-dependent leukemogenesis towards a novel therapeutic strategyPrincipal Investigator

Principal Investigator

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Development of novel antibodies against leukemia and elucidation of their blocking mechanismsPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

multi-pathogenesis aging research based on the Down syndrome aneuploidy model

Principal Investigator

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Research Institution

15-PGDH regulates leukemia stem cell potential in HOX-associated myeloid leukemia

Principal Investigator

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Research Institution

Superenhancer-mediated RUNX3 overexpression in EB virus-associated tumorigenesisPrincipal Investigator

Principal Investigator

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Research Institution

Development of a novel therapeutic method against acute megakaryoblastic leukemia by NOTCH agonistsPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

転写因子のPEBP2α/AML1の点変異による機能変化とその発癌能

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Trib1 promotes the development of acute myeloid leukemia in a Ts1Cje mouse model of Down syndrome.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The acidic domain of Hmga2 and the domain's linker region are critical for driving self-renewal of hematopoietic stem cell.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RUNX1-ETO (RUNX1-RUNX1T1) induces myeloid leukemia in mice in an age-dependent manner.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ZNF143 mediates CTCF-bound promoter enhancer loops required for murine hematopoietic stem and progenitor cell function2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tocilizumab Induces IL-10-Mediated Immune Tolerance in Invasive Candidiasis.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Super-enhancers for RUNX3 are required for cell proliferation in EBV-infected B cell lines.2021

Author(s)

Journal Title

DOI

Osato Motomi 大里元美

大里元美オオサトモトミ