OZAKI Shuji 尾崎修治

Researcher Number	90314872
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2010: 徳島大学, 病院, 講師 2006 – 2010: 徳島大学, 医学部・歯学部附属病院, 講師 2003 – 2004: The University of Tokushima, University Hospital, Assistant Professor, 医学部・歯学部附属病院, 講師 2002: The University of Tokushima, Univ.Hospital, Lecturer, 医学部附属病院, 講師 2000 – 2001: 徳島大学, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Hematology / Hematology Except Principal Investigator Hematology / Hematology
Keywords	Principal Investigator 造血器腫瘍 / モノクローナル抗体 / 分子標的治療 / 多発性骨髄腫 / 免疫療法 / Internalization / Immunotoxin / Molecular targeting therapy / Monoclonal antibody / Multiple myeloma … More / Hematolopical malignancies / インターナリゼーション / イムノトキシン / molecular targeting therapy / immnnotherapy / hematological malignancy / 造血器鍾瘍 / 脂質ラフト / 血液内科学 … More Except Principal Investigator IL-6 / osteoclast / VLA-4 / RANKL / 破骨細胞 / MIP-1 / 多発性骨髄腫 / osteopontin / angiogenesis / myeloma / オステオポンチン / 血管新生 / 骨髄腫細胞 / chemokine / multiple myeloma / ケモカイン / immunotherary / monoclonal antibody / hematoloeical malienanc / 免疫療法 / モノクローナル抗体 / 造血器腫瘍 Less

Development of novel therapy targeting lipid rafts in multiple myelomaPrincipal Investigator
- Principal Investigator
  
  OZAKI Shuji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokushima
Development of specific targeting against myebma cells by an internalizing antibodyPrincipal Investigator
- Principal Investigator
  
  OZAKI Shuji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokushima
Identification and clinical application of osteoclast-derived growth factors for myeloma
- Principal Investigator
  
  ABE Masahiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokushima
Elucidation of signal transduction pathway via HM1.24 and application toward the treatment of hematological malignanciesPrincipal Investigator
- Principal Investigator
  
  OZAKI Shuji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokushima
Development of immunotherapy targeting neoplastic lymphocyte-specific antigen (2D7) against hematological malignancies
- Principal Investigator
  
  MATSUMOTO Toshio
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokushima
Roles for MIP-1α and β in the development of osteolytic lesions in multiple myeloma
- Principal Investigator
  
  ABE Masahiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University OF Tokushima
造血器腫瘍におけるHM1.24蛋白の発現機構の解明と抗体療法に関する研究Principal Investigator
- Principal Investigator
  
  尾崎修治
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokushima

All 2011 2010 2009 2008 2007 2006

All Journal Article Presentation Book

[Book] Emerging Protein Biotherapeutics.(Biologic therapies for multiple myeloma and plasma cell disorders.)2009
- Author(s)
  Ozaki S.
- Publisher
  Editor Iqbal S. Grewal, CRC Press, Boca Raton, FL, USA
- Data Source
  KAKENHI-PROJECT-20591130
[Book] EBM血液疾患の治療2008-20092007
- Author(s)
  尾崎修治
- Total Pages
  658
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591067
[Book] 多発性骨髄腫up-to-date2006
- Author(s)
  尾崎修治
- Total Pages
  191
- Publisher
  メディカルレビュー社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591067
[Book] 多発性骨髄腫up-to-date2006
- Author(s)
  尾崎修治
- Total Pages
  191
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-18591067
[Journal Article] Transient inflammatory reaction during lenalidomide plus reduced-dose dexamethasone therapy in two patients with relapsed multiple myeloma.2011
- Author(s)
  Ozaki S, Harada T, Fujii S, Nakamura S, Miki H, Nakano A, Kagawa K, Takeuchi K, Abe M, Matsumoto T.
- Journal Title
  
  Int J Hematol 93
  
  Pages: 257-259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591130
[Journal Article] Transient inflammatory reaction during lenalidomide plus reduced-dose dexamethasone therapy in two patients with relapsed multiple myeloma.2011
- Author(s)
  Ozaki S, et al.
- Journal Title
  
  Int J Hematol
  
  Volume: 93 Pages: 257-259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591130
[Journal Article] TGF-β inhibition restores terminal osteoblast differentiation to suppress myeloma growth.2010
- Author(s)
  Takeuchi K, Abe M, Hiasa M, Oda A, Amou H, Kido S, Harada T, Tanaka O, Miki H, Nakamura S, Nakano A, Kagawa K, Yata K, Ozaki S, Matsumoto T.
- Journal Title
  
  PLoS ONE 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591130
[Journal Article] Size-controlled synthesis, surface functionalization, and biological applications of thiol-organosilica particles.2010
- Author(s)
  Nakamura M, Ozaki S, Abe M, Doi H, Matsumoto T, Ishimura K.
- Journal Title
  
  Colloids Surf B Biointerfaces 79
  
  Pages: 19-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591130
[Journal Article] Marked improvement of platelet transfusion refractoriness after bortezomib therapy in multiple myeloma.2009
- Author(s)
  Miki H, Ozaki S, Tanaka O, Lee E, Takimoto T, Watanabe H, Fujii S, Nakamura S, Kagawa K, Takeuchi K, Yata KI, Abe M, Kagami S, Matsumoto T.
- Journal Title
  
  Int J Hematol 89
  
  Pages: 223-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591130
[Journal Article] Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-lalpha and MIP-lbeta production.2009
- Author(s)
  Abe M, Hiura K, Ozaki S, Kido S, Matsumoto T.
- Journal Title
  
  J Bone Miner Metab 27
  
  Pages: 16-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591130
[Journal Article] A pharmacokinetic study evaluating the relationship between treatment efficacy and incidence of adverse events with thalidomide plasma concentrations in patients with refractory multiple myeloma.2009
- Author(s)
  Kodama T, Abe M, lida S, Ozaki S, Sakai A, Sawamura M, Shimazaki C, Miyata A, Wakayama T, Murakami H.
- Journal Title
  
  Clin Lymphoma Myeloma 9
  
  Pages: 154-159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591130
[Journal Article] GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-alpha converting enzyme (TACE).2009
- Author(s)
  Hiasa M, Abe M, Nakano A, Oda A, Amou H, Kido S, Takeuchi K, Kagawa K, Yata K, Hashimoto T, Ozaki S, Asaoka K, Tanaka E, Moriyama K, Matsumoto T.
- Journal Title
  
  Blood 114
  
  Pages: 4517-4526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591130
[Journal Article] Chimeric and humanized anti-HM1.24 antibodies mediate antibody- dependent cellular cytotoxicity against lung cancer cells.2009
- Author(s)
  Wang W, Nishioka Y, Ozaki S, Jalili A, Verma VK, Hanibuchi M, Abe S, Minakuchi K, Matsumoto T, Sone S.
- Journal Title
  
  Lung Cancer 63
  
  Pages: 23-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591130
[Journal Article]2009
- Author(s)
  Ozaki S
- Journal Title
  
  Biologic therapies for multiple myeloma and plasma cell disorders. Emerging Protein Biotherapeutics(CRC Press)
  
  Pages: 267-279
- Data Source
  KAKENHI-PROJECT-20591130
[Journal Article] HM1. 24 (CD317) is a novel target against lung cancer for immunotherapy using anti-HM1.24 antibody.2009
- Author(s)
  Wang W, Nishioka Y, Ozaki S, Jalili A, Abe S, Kakiuchi S, Kishuku M, Minakuchi K, Matsumoto T, Sone S.
- Journal Title
  
  Cancer Immunol Immunother 58
  
  Pages: 967-976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591130
[Journal Article] Interferon-alpha enhances CD317 expression and the antitumor activity of anti-CD317 monoclonal antibody in renal cell carcinoma xenograft models.2008
- Author(s)
  Kawai S, Azuma Y, Fujii E, Furugaki K, Ozaki S, Matsumoto T, Kosaka M, Yamada-Okabe H.
- Journal Title
  
  Cancer Sci 99
  
  Pages: 2461-2466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591130
[Journal Article] 多発性骨髄腫/分子生物学的研究-分子標的研究-2007
- Author(s)
  尾崎修治
- Journal Title
  
  日本臨床 65巻増刊号1
  
  Pages: 220-225
- Data Source
  KAKENHI-PROJECT-18591067
[Journal Article] 多発性骨髄腫/分子生物学的研究-分子標的研究-2007
- Author(s)
  尾崎修治
- Journal Title
  
  日本臨床 65
  
  Pages: 220-225
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591067
[Journal Article] 多発性骨髄腫/抗体療法2007
- Author(s)
  尾崎修治
- Journal Title
  
  日本臨床 65巻増刊号1
  
  Pages: 590-595
- Data Source
  KAKENHI-PROJECT-18591067
[Journal Article] Therapy with bortezomib plus dexamethasone induces osteoblast activation in responsive patients with multiple myeloma2007
- Author(s)
  Ozaki S, et. al.
- Journal Title
  
  Int J Hematol 86
  
  Pages: 180-185
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591067
[Journal Article] EBM therapy of hematological diseases2007
- Author(s)
  Ozaki, S
- Journal Title
  
  Chugai Igakusha
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591067
[Journal Article] Therapy with bortezomib plus dexamethasone induces osteoblast activation in responsive patients with multiple myeloma2007
- Author(s)
  Ozaki S, et. al
- Journal Title
  
  Int J Hematol 86
  
  Pages: 180-185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591067
[Journal Article] Therapy with bortezomib plus dexamethasone induces osteoblast activation in responsive patients with multiple myeloma2007
- Author(s)
  Ozaki., S, et. al.
- Journal Title
  
  Int J Hematol 86
  
  Pages: 180-185
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591067
[Journal Article] 多発性骨髄腫/抗体療法2007
- Author(s)
  尾崎修治
- Journal Title
  
  日本臨床 65
  
  Pages: 590-595
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591067
[Journal Article] 骨髄腫HM1.24抗原に対する細胞傷害性T細胞の誘導2006
- Author(s)
  尾崎修治
- Journal Title
  
  血液・腫瘍科 53巻1号
  
  Pages: 64-70
- Data Source
  KAKENHI-PROJECT-18591067
[Journal Article] Antibody therapy in multiple myeloma2006
- Author(s)
  Ozaki, S
- Journal Title
  
  Nippon Rinsho 65(suppl 1)
  
  Pages: 590-595
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591067
[Journal Article] 骨髄腫HM1.24抗原に対する細胞傷害性T細胞の誘導2006
- Author(s)
  尾崎修治
- Journal Title
  
  血液・腫瘍科 53
  
  Pages: 64-70
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591067
[Journal Article] Studies on molecular targets in multiple myeloma2006
- Author(s)
  Ozaki, S
- Journal Title
  
  Nippon Rinsho 65(suppl1)
  
  Pages: 220-225
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591067
[Journal Article] Multiple myeloma up-to-date2006
- Author(s)
  Ozaki, S
- Journal Title
  
  Medical View
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591067
[Journal Article] Induction of cytotoxic T cells against myeloma antigen HM1.242006
- Author(s)
  Ozaki, S
- Journal Title
  
  Hematology & Oncology 53
  
  Pages: 64-70
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591067
[Presentation] HLA class Iに特異的なsingle-chain Fv diabodyは骨髄腫細胞のside population分画に傷害を及ぼす2010
- Author(s)
  池亀彰茂, 尾崎修治, 辻大輔, 原田武志, 中村信元, 三木浩和, 中野綾子, 賀川久美子, 竹内恭子, 矢田健一郎, 安倍正博, 伊藤孝司, 松本俊夫
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-20591130
[Presentation] 骨髄腫細胞のside populationを標的としたHLA class Iに特異的なscFv diabodyの抗腫瘍効果2009
- Author(s)
  池亀彰茂, 尾崎修治, 辻大輔, 原田武志, 中村信元, 三木浩和, 中野綾子, 賀川久美子, 竹内恭子, 矢田健一郎, 安倍正博, 伊藤孝司, 松本俊夫
- Organizer
  第71回日本血液学会総会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-20591130
[Presentation] A recombinant HLA class I-specific single-chain Fv diabody can target cancer stem cell-like side population cells in multiple myeloma.2009
- Author(s)
  Akishige Ikegame, Shuji Ozaki, Daisuke Tsuji, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Ayako Nakano, Kumiko Kagawa, Kyoko Takeuchi, Ken-ichiro Yata, Masahiro Abe, Kohji Itoh, Toshio Matsumoto.
- Organizer
  51^<th> Annual Meeting of the American Society of Hematology
- Place of Presentation
  New Orleans, Louisiana, USA
- Data Source
  KAKENHI-PROJECT-20591130
[Presentation] Spicamycin誘導体KRN5500は骨髄腫細胞とともに破骨細胞の生存を抑制し,抗腫瘍効果を発揮する2008
- Author(s)
  三木浩和, 尾崎修治, 田中修, 藤井志朗, 中村信元, 賀川久美子, 竹内恭子, 坂井晃, 矢田健一郎, 安倍正博, 松本俊夫
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-20591130
[Presentation] KRN5500, a spicamycin derivative, exerts anti-myeloma effects through impairing both myeloma cells and osteoclasts.2008
- Author(s)
  Hirokazu Miki, Shuji Ozaki, Osamu Tanaka, Shingen Nakamura, Ayako Nakano, Kumiko Kagawa, Kyoko Takeuchi, Ken-ichiro Yata, Masahiro Abe, Toshio Matsumoto.
- Organizer
  50^<th> Annual Meeting of the American Society of Hematology
- Place of Presentation
  San Francisco, CA, USA
- Data Source
  KAKENHI-PROJECT-20591130
[Presentation] 再発・難治性多発性骨髄腫に対するbortezomib+dexamethasone併用療法の治療成績2007
- Author(s)
  尾崎修治
- Organizer
  第69回日本血液学会総会第49回日本臨床血液学会
- Place of Presentation
  横浜
- Year and Date
  2007-10-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591067
[Presentation] Bortezomib plus dexamethasone therapy for relapsed or refractory multiple myeloma2007
- Author(s)
  Ozaki, S, et. al.
- Organizer
  The 69th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Yokohama
- Year and Date
  2007-10-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591067
[Presentation] 再発・難治性多発性骨髄腫に対するbortezomib+dexamethasone併用療法の治療成績2007
- Author(s)
  尾崎修治
- Organizer
  第69回日本血液学会総会学会第49回日本臨床血液学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-12
- Data Source
  KAKENHI-PROJECT-18591067
[Presentation] Antibody-targeted therapy of multiple myeloma by internalizing human monoclonal antibody to HM1.242006
- Author(s)
  Ozaki, S, et. al.
- Organizer
  The 68th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Fukuoka
- Year and Date
  2006-10-07
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591067
[Presentation] HM1.24抗原に特異的なインターナライズ抗体を用いた多発性骨髄腫のターゲティング療法2006
- Author(s)
  尾崎修治
- Organizer
  第68回日本血液学会総会第48回日本臨床血液学会
- Place of Presentation
  福岡
- Year and Date
  2006-10-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591067

1. ABE Masahiro (80263812)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. MATSUMOTO Toshio (20157374)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. INOUE Daisuke (60314853)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KAWAI Shigeto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SHIBATA Hironobu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OZAKI Shuji 尾崎 修治

Research Projects

Research Products

Co-Researchers

Development of novel therapy targeting lipid rafts in multiple myelomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of specific targeting against myebma cells by an internalizing antibodyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and clinical application of osteoclast-derived growth factors for myeloma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of signal transduction pathway via HM1.24 and application toward the treatment of hematological malignanciesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of immunotherapy targeting neoplastic lymphocyte-specific antigen (2D7) against hematological malignancies

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles for MIP-1α and β in the development of osteolytic lesions in multiple myeloma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

造血器腫瘍におけるHM1.24蛋白の発現機構の解明と抗体療法に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Emerging Protein Biotherapeutics.(Biologic therapies for multiple myeloma and plasma cell disorders.)2009

Author(s)

Publisher

Data Source

[Book] EBM血液疾患の治療2008-20092007

Author(s)

Total Pages

Publisher

Description

Data Source

[Book] 多発性骨髄腫up-to-date2006

Author(s)

Total Pages

Publisher

Description

Data Source

[Book] 多発性骨髄腫up-to-date2006

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Transient inflammatory reaction during lenalidomide plus reduced-dose dexamethasone therapy in two patients with relapsed multiple myeloma.2011

Author(s)

Journal Title

Data Source

[Journal Article] Transient inflammatory reaction during lenalidomide plus reduced-dose dexamethasone therapy in two patients with relapsed multiple myeloma.2011

Author(s)

Journal Title

Data Source

[Journal Article] TGF-β inhibition restores terminal osteoblast differentiation to suppress myeloma growth.2010

Author(s)

Journal Title

Data Source

[Journal Article] Size-controlled synthesis, surface functionalization, and biological applications of thiol-organosilica particles.2010

OZAKI Shuji 尾崎修治