Watanabe Atsushi 渡邉淳

… Alternative Names

WATANABE ATSUSHI 渡邉淳

WATANABE Atsushi 渡邉淳

渡邊淳ワタナベアツシ

渡邉淳ワタナベアツシ

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Researcher Number	90321843
Affiliation (Current)	2025: 国立研究開発法人国立長寿医療研究センター, 研究所研究推進基盤センター, 室長
Affiliation (based on the past Project Information) *help	2022 – 2024: 国立研究開発法人国立長寿医療研究センター, 研究所研究推進基盤センター, 室長 2021: 国立研究開発法人国立長寿医療研究センター, 研究推進基盤センター, 室長 2018 – 2020: 国立研究開発法人国立長寿医療研究センター, 共同利用推進室, 室長 2013: 国立長寿医療研究センター, 共同利用推進室, 室長 2010 – 2013: 独立行政法人国立長寿医療研究センター, 共同利用推進室, 室長 … More 2010: 国立長寿医療研究センター, 共同利用推進室, 室長 2009: 国立長寿医療センター(研究所), 加齢健康脳科学研究部, 室長 2009: 国立長寿医療センター, 血管性認知症研究部, 室長 2008: 国立長寿医療センター(研究所), 血管性認知症研究部, 室長 2008: 愛知学院大学, 国立長寿医療センター・血管性認知症研究部, 室長 Less
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / Basic Section 51030:Pathophysiologic neuroscience-related / Nerve anatomy/Neuropathology Except Principal Investigator Basic Section 52030:Psychiatry-related / Dental engineering/Regenerative dentistry / Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Conservative dentistry
Keywords	Principal Investigator アルツハイマー病 / Aβ / ApoE / プロテオーム解析 / バイオマーカー / 痴呆 / プロテオーム / 脳神経疾患 / 認知症 Except Principal Investigator PET炎症イメージング … More / アルツハイマー型認知症 / プロテオミクス / 歯髄再生 / 歯髄幹細胞 / APP / 基質結合部位 / アルツハイマー病 / 運動 / 呼吸器 / マイオカイン / COPD / 運動モデル / 細胞老化 / 全身性炎症 / 炎症系サイトカイン / 精神行動症状 / グリア細胞 / 炎症イメージング / トランスロケーター蛋白(TSPO) / 血液バイオマーカー / 認知症行動心理症状 / トランスロケーター蛋白 / ポジトロンCT / 脳内神経炎症 / う蝕治療 / 間葉系幹細胞 / iPS細胞 / 加圧刺激 / 細管象牙質形成 / 歯髄創傷治癒 / MMP3 / 血管新生 / ショットガン法 / 歯髄創傷治癒法 / 質量分析 / 歯髄再生促進因子 / 歯髄炎治療薬 / 象牙質・歯髄再生 / 組織幹細胞 / 歯髄マーカー / プロテオーム / 再生歯学 Less

ApoEのアイソフォームの違いによるAβ重合メカニズムの解析Principal Investigator
- Principal Investigator
  
  渡邉淳
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  National Center for Geriatrics and Gerontology
基質結合部位を標的とする副作用を抑えたアルツハイマー病の治療薬開発
- Principal Investigator
  
  福森亮雄
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Osaka Medical and Pharmaceutical University
The research of the systemic inflammation as a cause of neuropsychiatric symptoms in Alzheimer's disease
- Principal Investigator
  
  安野史彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  National Center for Geriatrics and Gerontology
運動による老化細胞除去機構の解明ー慢性呼吸器疾患治療モデルへの展開
- Principal Investigator
  
  杉本昌隆
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
In vivo investigation of neuroinflammation of AD with PET molecular imaging
- Principal Investigator
  
  Yasuno Fumihiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  National Center for Geriatrics and Gerontology
Proteomic variation analysis of plasma in Alzheimer's DiseasePrincipal Investigator
- Principal Investigator
  
  WATANABE ATSUSHI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Center for Geriatrics and Gerontology
Research and development of innovative caries treatment by biotooth transplantation using iPS cells
- Principal Investigator
  
  NAKASHIMA MISAKO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  National Center for Geriatrics and Gerontology
Analysis of the vascular degeneration mechanism in familial vascular dementia CADASILPrincipal Investigator
- Principal Investigator
  
  WATANABE Atsushi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  National Center for Geriatrics and Gerontology
Demonstration of transdifferentiation of other tissue stem cells into dental pulp stem cells by a pulp biomarker
- Principal Investigator
  
  NAKASHIMA Misako
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  National Institute for Longevity Sciences,NCGG
Novel pulp treatment agent with stimulator for pulp regeneration
- Principal Investigator
  
  SHIBATA Naoki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Aichi Gakuin University

All 2023 2022 2020 2019 2018 2013 2012 2011 2010

All Journal Article Presentation

[Journal Article] An involvement of inflammation in medial temporal region in generation of agitation in Alzheimer’s disease: an in vitro positron emission tomography study.2023
- Author(s)
  Yasuno F, Kimura Y, Ogawa A, Ikenuma H, Abe J, Minami H, Nihashi T, Yokoi K, Hattori S, Shimada N, Watanabe A, Kasuga K, Ikeuchi T, Takeda A, Sakurai T, Ito K, Kato T
- Journal Title
  
  Psychogeriatrics
  
  Volume: 23 Issue: 1 Pages: 126-135
- DOI
  10.1111/psyg.12915
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18262, KAKENHI-PROJECT-22K07610
[Journal Article] Neuroimaging biomarker of microglial activation for predicting annual decline of cognitive function in patients with Alzheimer’s disease2023
- Author(s)
  Yasuno F, Kimura Y, Ogata A, Ikenuma H, Abe J, Minami H, Nihashi T, Yokoi K, Hattori S, Shimoda N, Watanabe A, Kasuga K, Ikeuchi T, Takeda A, Sakurai t, Ito k, Kato T
- Journal Title
  
  Brain Behavior Immunity
  
  Volume: 114 Pages: 214-220
- DOI
  10.1016/j.bbi.2023.08.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18262, KAKENHI-PROJECT-22K07610
[Journal Article] Estimation of blood-based biomarkers of glial activation related to neuroinflammation2022
- Author(s)
  Yasuno Fumihiko、Watanabe Atsushi、Kimura Yasuyuki、Yamauchi Yumeka、Ogata Aya、Ikenuma Hiroshi、Abe Junichiro、Minami Hiroyuki、Nihashi Takashi、Yokoi Kastunori、Hattori Saori、Shimoda Nobuyoshi、Kasuga Kensaku、Ikeuchi Takeshi、Takeda Akinori、Sakurai Takashi、Ito Kengo、Kato Takashi
- Journal Title
  
  Brain, Behavior, Immunity - Health
  
  Volume: 26 Pages: 100549-100549
- DOI
  10.1016/j.bbih.2022.100549
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07610
[Journal Article] Brain Microvascular Accumulation and Distribution of the N0TCH3 ectodomain and GOM in CADASIL2013
- Author(s)
  Yumi Yamamoto, Lucy Craggs, et al.
- Journal Title
  
  Journal of Neuropathology and Experimental Neurology
  
  Volume: 72 Issue: 5 Pages: 416-431
- DOI
  10.1097/nen.0b013e31829020b5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07954, KAKENHI-PROJECT-22500327
[Journal Article] Complete pulp regeneration after pulpectomy by transplantation of CD105^+ stem cells with SDF-1.2011
- Author(s)
  Iohara K., Imabayashi K., Ishizaka R., Watanabe A., Nabekura J., Ito M., Matsushita K., Nakamura H., Nakashima M.
- Journal Title
  
  Tissue Eng.Part A. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390504
[Journal Article] Complete pulp regeneration after pulpectomy by transplantation of CD105^+ stem cells with SDF-12011
- Author(s)
  Iohara K., Imabayashi K., Ishizaka R., Watanabe A., Nabekura J., Ito M., Matsushita K., Nakamura H., Nakashima M.
- Journal Title
  
  Tissue Eng.Part A.
  
  Volume: Mar.18(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390504
[Journal Article] Complete Pulp Regeneration After Pulpectomy by Transplantation of CD105+ Stem Cells with Stromal Cell-Derived Factor-12011
- Author(s)
  Iohara K., Imabayashi K., Ishizaka R., Watanabe A., Nabekura J., Ito M., Matsushita K., Nakamura H., Nakashima M
- Journal Title
  
  Tissue Eng.Part A.
  
  Volume: 17(15-16) Pages: 1911-190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390456
[Journal Article] Potent inhibitors of amyloid ss fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3.2010
- Author(s)
  Takahashi K, Adachi K, Kunimoto S, Wakita H, Takeda K, Watanabe A
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 402 Pages: 54-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500327
[Journal Article] Potent inhibitors of amyloid ss fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3.2010
- Author(s)
  Takahashi K, Adachi K, Kunimoto S, Wakita H, Takeda K, and Watanabe A.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 402巻 Issue: 1 Pages: 54-58
- DOI
  10.1016/j.bbrc.2010.09.105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500327
[Presentation] Biomarkers of Glial Activation Related to Neuroinflammation2023
- Author(s)
  Yasuno F, Watanabe A, Kimura Y, Yamauchi Y, Ogata A, Ikenuma H, Abe J, MinamiH, Nihashi T, Yokoi K, Hattori S, Shimoda N, Kasuga K, Ikeuchi T, Takeda A,Sakurai T, Ito K, Kato T
- Organizer
  IAGG Asia/Oceania Regional Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07610
[Presentation] アルツハイマー型認知症における精神行動症状と血漿IL-6濃度の関係について2023
- Author(s)
  安野史彦, 渡邉淳, 木村泰之, 山内夢叶, 小縣綾, 阿部潤一郎, 南博之, 二橋尚志, 横井克典, 服部沙織, 下田信義, 春日健作, 池内健, 武田章敬, 櫻井孝, 伊藤健吾, 加藤隆司
- Organizer
  第42回日本認知症学会
- Data Source
  KAKENHI-PROJECT-22K07610
[Presentation] 神経炎症を推定可能な血液バイオマーカーに関する研究2022
- Author(s)
  安野史彦、渡邉淳、木村泰之、山内夢叶、小縣綾、阿部潤一郎、南博之、二橋尚志、横井克典、服部沙織、下田信義、春日健作、池内健、武田章敬、櫻井孝、伊藤健吾、加藤隆司
- Organizer
  第44回生物学的精神医学会/第32回神経精神薬理学会/第52回臨床精神神経薬理学会/第6回精神薬学会：合同年会
- Data Source
  KAKENHI-PROJECT-22K07610
[Presentation] 神経炎症と認知症アジテーション症状との関係2022
- Author(s)
  安野史彦、木村泰之、小縣綾、阿部潤一郎、南博之、二橋尚志、横井克典、服部沙織、下田信義、春日健作、渡邉淳、池内健、武田章敬、櫻井孝、伊藤健吾、加藤隆司
- Organizer
  第37回　日本老年精神医学会, 第41回　日本認知症学会学術集会:合同年会
- Data Source
  KAKENHI-PROJECT-22K07610
[Presentation] Sirt2 increases tau phosphorylation via ERK activation2020
- Author(s)
  Zhou CY, Jung CG, Watanabe A, Ferdous T, Abdelhamid M, Michikawa M.
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07383
[Presentation] アルツハイマー病患者の血漿タンパク質の変動解析2019
- Author(s)
  渡邉　淳
- Organizer
  第３８回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07383
[Presentation] 血漿中の変性Apolipoprotein Eの解析2018
- Author(s)
  渡邉淳
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07383
[Presentation] 変異型Notch3ノックインマウスの生化学的解析2012
- Author(s)
  渡邉淳、國本正子、高橋慶吉
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場（茨城県）
- Data Source
  KAKENHI-PROJECT-22500327
[Presentation] 変異型Notch3ノックインマウスの生化学的解析2012
- Author(s)
  渡邉淳、國本正子、高橋慶吉
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば
- Year and Date
  2012-10-27
- Data Source
  KAKENHI-PROJECT-22500327
[Presentation] 血管性認知症モデル動物のプロテオーム解析2011
- Author(s)
  渡邉淳、足立香代、新飯田俊平、丸山和佳子、脇田英明
- Organizer
  第30回日本認知症学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22500327
[Presentation] 変異型Notch3ノックインマウスを用いた慢性ストレス暴露によるCADASILモデルマウスの構築2011
- Author(s)
  國本正子、高橋慶吉、足立香代、松崎三記子、武田和也、脇田英明、 Rajesh N Kalaria、丸山和佳子、渡邉淳
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22500327
[Presentation] CD105陽性幹細胞を用いた歯髄特異的タンパク質の検索2011
- Author(s)
  今林貴代美、渡邉淳、庵原耕一郎、石坂亮、中島美砂子.
- Organizer
  第10回日本歯科再生医療学会総会
- Place of Presentation
  東京
- Year and Date
  2011-03-02
- Data Source
  KAKENHI-PROJECT-20390504
[Presentation] 血管性認知症モデル動物のプロテオーム解析2011
- Author(s)
  渡邉淳、足立香代、新飯田俊平、丸山和佳子、脇田英明
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22500327
[Presentation] 歯髄組織再生におけるvimentinの作用2011
- Author(s)
  今林貴代美、庵原耕一郎、渡邉淳、石坂亮、中村洋、中島美砂子
- Organizer
  第134回日本歯科保存学会2011年度春季学術大会
- Place of Presentation
  東京
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-23390456
[Presentation] The molecular pathology of the CADASIL2010
- Author(s)
  Watanabe A
- Organizer
  BMB2010第33回日本分子生物学会年会、第83回日本生化学会年会、合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22500327
[Presentation] The molecular pathology of the CADASIL BMB20102010
- Author(s)
  Watanabe A
- Organizer
  第33回日本分子生物学会年会、第83回日本生化学会年会、合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22500327
[Presentation] ヒト変異Notch3重合体の分解促進剤のスクリーニング2010
- Author(s)
  渡邉淳、足立香代、國本正子、武田和也、脇田英明、丸山和佳子、高橋慶吉
- Organizer
  第29回日本認知症学会
- Place of Presentation
  名古屋
- Year and Date
  2010-11-05
- Data Source
  KAKENHI-PROJECT-22500327
[Presentation] Proteomic analysis of the mutant Notch3-expressing cells and the microvessels of CADASIL brain2010
- Author(s)
  Watanabe A, Kunimoto S, Adachi K, Takeda K, Niida S, Wakita H, Kalaria RN, and Takahashi K.
- Organizer
  International conference on Alzheimer's disease (ICAD)
- Place of Presentation
  Honolulu
- Year and Date
  2010-07-11
- Data Source
  KAKENHI-PROJECT-22500327
[Presentation] ヒト変異Notch3重合体の分解促進剤のスクリーニング2010
- Author(s)
  渡邉淳、足立香代、國本正子、武田和也、脇田英明、丸山和佳子、高橋慶吉
- Organizer
  第29回日本認知症学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2010-11-05
- Data Source
  KAKENHI-PROJECT-22500327

1. NAKASHIMA Misako (20207773)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. NAKAMURA Hiroshi (40064878)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. IOHARA Kouichiro (60435865)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. Yasuno Fumihiko (60373388)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. 木村泰之 (20423171)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. 加藤隆司 (60242864)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. SHIBATA Naoki (60291770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MURAKAMI Masashi (30614531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小縣綾 (10805857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 田岡俊昭 (30305734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 杉本昌隆 (50426491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 村上太郎 (10252305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 多田敬典 (20464993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 細山徹 (20638803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 福森亮雄 (00788185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 池内健

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Watanabe Atsushi 渡邉 淳

WATANABE ATSUSHI 渡邉 淳

WATANABE Atsushi 渡邉 淳

渡邊 淳 ワタナベ アツシ

渡邉 淳 ワタナベ アツシ

Research Projects

Research Products

Co-Researchers

ApoEのアイソフォームの違いによるAβ重合メカニズムの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

基質結合部位を標的とする副作用を抑えたアルツハイマー病の治療薬開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The research of the systemic inflammation as a cause of neuropsychiatric symptoms in Alzheimer's disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

運動による老化細胞除去機構の解明ー慢性呼吸器疾患治療モデルへの展開

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

In vivo investigation of neuroinflammation of AD with PET molecular imaging

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Proteomic variation analysis of plasma in Alzheimer's DiseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research and development of innovative caries treatment by biotooth transplantation using iPS cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the vascular degeneration mechanism in familial vascular dementia CADASILPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Demonstration of transdifferentiation of other tissue stem cells into dental pulp stem cells by a pulp biomarker

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel pulp treatment agent with stimulator for pulp regeneration

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] An involvement of inflammation in medial temporal region in generation of agitation in Alzheimer’s disease: an in vitro positron emission tomography study.2023

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[Journal Article] Neuroimaging biomarker of microglial activation for predicting annual decline of cognitive function in patients with Alzheimer’s disease2023

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[Journal Article] Estimation of blood-based biomarkers of glial activation related to neuroinflammation2022

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Watanabe Atsushi 渡邉淳

WATANABE ATSUSHI 渡邉淳

WATANABE Atsushi 渡邉淳

渡邊淳ワタナベアツシ

渡邉淳ワタナベアツシ