ISOMOTO Hajime 磯本一

… Alternative Names

ISOMOTO Hazime 磯本一

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Researcher Number	90322304
External Links
Affiliation (Current)	2025: 鳥取大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 鳥取大学, 医学部, 教授 2015 – 2019: 鳥取大学, 医学部, 教授 2017: 鳥取大学, 医学部附属病院・消化器内科, 教授 2014 – 2015: 長崎大学, 病院(医学系), 准教授 2009 – 2014: Nagasaki University, 大学病院, 准教授 … More 2012: 長崎大学, 病院, 准教授 2011: 長崎大学, 病院, 講師 2011: 長崎大学, 長崎大学病院, 准教授 2009 – 2010: Nagasaki University, 病院, 准教授 2009: 長崎大学, 大学病院, 講師 2009: 長崎大学, 病院, 講師 2007 – 2008: Nagasaki University, 医学部・歯学部附属病院, 講師 2004: 長崎大, 医学部・歯学部附属病院, 助手 2002 – 2003: 長崎大学, 医学部附属病院, 助手 2000 – 2001: 長崎大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Digestive surgery / Bacteriology (including Mycology) / Biological Sciences / Gastroenterology / Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 52040:Radiological sciences-related / Basic Section 62030:Learning support system-related / Laboratory medicine / Gastroenterology
Keywords	Principal Investigator 化学放射線療法 / 食道扁平上皮癌 / 内視鏡 / 顕微鏡 / 消化器癌 / イメージング / 消化器がん細胞株 / 膵臓癌 / 胆道癌 / がん細胞株 … More / 消化器悪性腫瘍 / アミノレブリン酸 / LCTF / 光線力学診断 / タラポルフィリンナトリウム / タラポルフィンナトリウム / 扁平上皮癌 / 食道癌 / 光線力学的療法 / 光線力学療法 / バレット食道・腺癌 / エキソソーム / パピローマウイルス / アカラシア / 逆流性食道炎 / 内視鏡的粘膜下層剥離術 / マイクロRNA / JAK / miRNA-205 / IL-6 / stat3 / miR-29b / miR-205 / micro RNA / esophagus / squamous cell carcinoma / 上皮間葉転換 / microRNA-10a / microRNA-205 / SOCS3 / epigenetics / microRNA / STAT3 / Mcl-1 / colitis / gene target / NF-kappaB / IL-1 / IL-8 / mouse / knock out / WASP / cagA / SAGE法 / 遺伝子 / 感受性 / Helicobater pylori / cag / アポトーシス / E2F / スナネズミ / 感受性遺伝子 / Helicobacter pylori … More Except Principal Investigator VacA / 毒性発現 / 細菌毒素 / ヘリコバクター・ピロリ / ピロリ菌 / CagA / 光線力学療法 / PI3K / エフェクター / Helicobacter pylori / 若年者 / 消化器がん新規内視鏡治遼 / 内視鏡的局注療法 / 消化器がん新規内視鏡治療 / 短寿命α線放出核種 / ロボット / 会話分析 / 手技評価 / 内視鏡シミュレータ / 音声指導 / 圧力検出機能 / シミュレータ / 手技の定量化 / 画像解析 / 圧力センサー / シミュレーター / 大腸内視鏡 / IoT / 自主学習 / 手技定量化 / 大腸内視鏡シミュレータ / 光線力学診断 / 消化管癌 / 光線力学的診断 / polyclonal antibody / polypeptides / eosinophil cationic protein: ECP / ulcerative colitis / eosinophil cationic protein / 潰瘍性大腸炎 / ポリクローナル抗体 / ポリペプチド / eosinophil cationic protein : ECP / 膵癌 / 光線力学的療法「 / 胆道癌 / 胆管癌 / 糖鎖連結クロリン / 光線力学的療法 / 緊急被ばく医療 / 急性放射線症候群 / 放射線腸炎 / 放射線皮膚潰瘍 / 放射線障害 / 間葉系前駆細胞 / 再生阻害局所環境 / 多分化能 / スクリーニング / 放射線晩発性障害 / 毒素受容体 / 毒素作用 / VacA受容体 / 細菌毒素受容体 / アポトーシス / 相乗効果 / 抗癌剤 / レザフィリン / フォトフリン / 胆管癌細胞株 / 光線力学療法(PDT) / 光線力学的療法(PDT) / 細胞内Ca2+濃度 / Akt / エピジェネティック / microRNA / 毒作用 / IL-8 / COX-2 / ATF-2 経路 / GSK3β / Akt経路 / ATF-2経路 / P38 MAP kinase / エンドサイトーシス / 毒素侵入 / 遺伝子多型 / 細菌由来病原因子 / 細胞死 / サイトカイン産生 / SAGE / Helicobacter heilmanni Less

短寿命α線放出核種医薬品の内視鏡的局注療法による消化器がん新規治療戦略の開発
- Principal Investigator
  
  山口直之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Nagasaki University
若年者ピロリ検診の実装化とピロリ胃炎進展メカニズムの解明
- Principal Investigator
  
  八島一夫
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Tottori University
Development of a colonoscopy simulator system with automatic voice insertion guidance and evaluation functions
- Principal Investigator
  
  UEKI Masaru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62030:Learning support system-related
- Research Institution
  Tottori University
establishment of novel imaging using LCTF for gastrointestinal cancerPrincipal Investigator
- Principal Investigator
  
  ISOMOTO Hajime
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tottori University
Fundamental and clinical research on new laser photodynamic diagnosis for gastrointestinal cancer
- Principal Investigator
  
  MATSUSHIMA Kayoko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagasaki University
Molecular basis for clinical cancer stem cell targeted photodynamic therapyPrincipal Investigator
- Principal Investigator
  
  Isomoto Hajime
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tottori University
  Nagasaki University
Development of Local Treatment for Bile Duct Carcinoma by PDT Applying the New Glucose-Conjugated Chlorin
- Principal Investigator
  
  Nanashima Atsushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Miyazaki
  Nagasaki University
Regenerative therapy using autogenic adipocyte-derived progenitor cells for radiation colitis
- Principal Investigator
  
  OHTSURU Akira
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Fukushima Medical University
Analysis on multifunctional receptors for Helicobacter pylori VacA
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
Clinical significance of esophageal squamous cell carcinoma-specific microRNA in circulation and tissuePrincipal Investigator
- Principal Investigator
  
  ISOMOTO Hajime
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
ヘリコバクター・ピロリVacA毒素の毒性発現機序
- Principal Investigator
  
  平山壽哉
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Development of new treatment applying photodynamic therapy in bile duct carcinoma
- Principal Investigator
  
  NANASHIMA Atsushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nagasaki University
ヘリコバクター・ピロリVacA毒素の毒性発現機序
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Toxicity of Helicobacter pylori VacA and its mutual effect with CagA
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
Clinical significance and regulatory mechanisms of Mcl-1 in esophageal squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  ISOMOTO Hajime
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
WASP欠損マウスに自然発症する腸炎の原因解明に関する研究Principal Investigator
- Principal Investigator
  
  磯本一
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
SAGE法によるヘリコバクターヘルマニー感染応答遺伝子の解析
- Principal Investigator
  
  村瀬邦彦
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
SAGE法によるHelicobacter pylori感受性遺伝子の同定と機能解析Principal Investigator
- Principal Investigator
  
  磯本一
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
Molecular action mechanism of eosinophil granule proteins in destruction of mucosal cells in ulcerative colitis
- Principal Investigator
  
  MAKIYAMA Kazuya
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University Hospital

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All Journal Article Presentation Book

[Book] Development of novel treatments for radiation-related diseases in nuclear power plant acciden . ＡNew Challenge of Radiation Health Risk Management NAKASHIMA,M et.al.(eds)2012
- Author(s)
  OHTSURU,A*:AKITA,S:KUMAGAI,A*:ISOMOTO,H:USA,T:SUZUKI,K:HIRANO,A:YAMASHITA,S*
- Publisher
  Nagasaki Newspaper Publish
- Data Source
  KAKENHI-PROJECT-23590946
[Book] A New Challenge of Radiation Health Risk Management2012
- Author(s)
  A. Ohtsuru, S. Akita, A. Kumagai, H. Isomoto, T. Usa, K. Suzuki,　A.Hirano, S. Yamashita.
- Total Pages
  276
- Publisher
  Nagasaki Newspaper Publish
- Data Source
  KAKENHI-PROJECT-23590946
[Journal Article] 内視鏡画像内の光源反射を考慮したCNNによる撮影部位推定2022
- Author(s)
  勝山隼，藤井政至，上原一剛，植木賢，磯本一，近藤克哉
- Journal Title
  
  電子情報通信学会技術研究報告
  
  Volume: vol.122, no.417 Pages: 199-204
- Data Source
  KAKENHI-PROJECT-21H03566
[Journal Article] Objective tumor distinction in 5-aminolevulinic acid-based endoscopic photodynamic diagnosis, using a spectrometer with a liquid crystal tunable filter.2020
- Author(s)
  Yamashita T, Kinoshita H, Sakaguchi T, Isomoto H.
- Journal Title
  
  Ann Transl Med.
  
  Volume: 8 Issue: 5 Pages: 178-187
- DOI
  10.21037/atm.2020.01.108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09475
[Journal Article] Expression of coproporphyrinogen oxidase is associated with detection of upper gastrointestinal carcinomas by 5-aminolevulinic acid-mediated photodynamic diagnosis2017
- Author(s)
  Ogihara Kumi、Isomoto Hajime、Kurumi Hiroki、Kanda Tsutomu、Hashisako Mikiko、Tabata Kazuhiro、Ishii Hiroyuki、Ohnita Ken、Yamaguchi Naoyuki、Akazawa Yuko、Matsushima Kayoko、Takeshima Fuminao、Kunizaki Masaki、Hidaka Shigekazu、Nanashima Atsushi、Fukuoka Junya、Nagayasu Takeshi、Nakao Kazuhiko
- Journal Title
  
  Photodiagnosis and Photodynamic Therapy
  
  Volume: 19 Pages: 15-21
- DOI
  10.1016/j.pdpdt.2017.04.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K21236
[Journal Article] In vivo fluorescence navigation of gastric and upper gastrointestinal tumors by 5-aminolevulinic acid mediated photodynamic diagnosis with a laser-equipped video image endoscope2015
- Author(s)
  Isomoto H, Nanashima A, Senoo T, Ogiwara K, Hashisako M, Ohnita K, Yamaguchi N, Kunizaki M, Hidaka S, Fukuda H, Ishii H, Matsushima K, Minami H, Akazawa Y, Takeshima F, Fukuoka J, Nagayasu T, Nakao K.
- Journal Title
  
  Photodiagnosis and Photodynamic Therapy
  
  Volume: 12(2) Issue: 2 Pages: 201-208
- DOI
  10.1016/j.pdpdt.2015.03.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K21236, KAKENHI-PROJECT-25462120
[Journal Article] 消化器癌に対するPDD…とくに胃腫瘍に対する5-ALAを用いたPDD2015
- Author(s)
  松島加代子, 磯本一, 荻原久美, 妹尾健正, 山口直之, 大仁田賢, 竹島史直, 中尾一彦
- Journal Title
  
  G.I.Reasearch
  
  Volume: 23(4) Pages: 323-331
- Data Source
  KAKENHI-PROJECT-15K21236
[Journal Article] Interweaving microRNAs and proinflammatory cytokines in gastric mucosa with reference to H. pylori infection.2012
- Author(s)
  Isomoto H, Matsushima K, Inoue N, Hayashi T, Nakayama T, Kunizaki M, Hidaka S, Nakayama M, Hisatsune J, Nakashima M, Nagayasu T, Nakao K, Hirayama T.
- Journal Title
  
  J Clin Immunol
  
  Volume: 32 Pages: 290-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] Interweaving microRNAs and proinflammatory cytokines in gastric mucosa with reference to H. pylori infection2012
- Author(s)
  Isomoto H. et al.
- Journal Title
  
  J Clin Immunol.
  
  Volume: 32 Issue: 2 Pages: 290-299
- DOI
  10.1007/s10875-011-9626-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084, KAKENHI-PROJECT-24659199, KAKENHI-PROJECT-24791999
[Journal Article] Low-density Lipoprotein Receptor-related Protein-1 (LRP1) Mediates Autophagy and Apoptosis Caused by Helicobacter pyloriVacA2012
- Author(s)
  Yahiro K, Satoh M, Nakano M, Hisatsune J, Isomoto H, Sap J, Suzuki H, Nomura F, Noda M, Moss J, Hirayama T.
- Journal Title
  
  J Biol Chem.
  
  Volume: 287 Pages: 3104-15
- NAID
  120006985783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells2011
- Author(s)
  K.Matsushima,H.Isomoto,N.Yamaguchi,N.Inoue H.Machida,T.Nakayama,T.Hayashi,M.Kunizaki, S. Hidaka, T. Nagayasu, M. Nakashima, K. Ujifuku, N. Mitsutake, A.Ohtsuru,S.Yamashita,et.al
- Journal Title
  
  J Transl Med
  
  Volume: 9 Pages: 1-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590946
[Journal Article] 胆管癌に新規光感受性物質レザフィリンを用いたPhotodynamic therapy 3例の安全性に関する検討2011
- Author(s)
  七島篤志、阿保貴章、森崎智仁、植原亮平、三嶋亮介、大仁田賢、磯本一
- Journal Title
  
  胆道
  
  Volume: 25巻2号 Pages: 220-227
- NAID
  130004545395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591777
[Journal Article] Helicobacter pylori VacA reduces cellular expression of STAT3 and pro-survival Bcl-2 family proteins, Bcl-2 and Bcl-XL, leading to apoptosis in gastric epithelial cells.2011
- Author(s)
  Matsumoto A, Isomoto H, Nakayama M, Hisatsune J, Nishi Y, Nakashima Y, Matsushima K, Kurazono H, Nakao K, Hirayama T, and Kohno S
- Journal Title
  
  Dig. Dis. Sci.
  
  Volume: 56 Pages: 999-1006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] MicroRNA signatures in Helicobacter pylori-infected gastric mucosa2011
- Author(s)
  Matsushima K, Isomoto H, Inoue N, Nakayama T, Hayashi T, Nakayama M, Nakao K, Hirayama T, Kohno S.
- Journal Title
  
  Int .J. Cancer
  
  Volume: 128 Pages: 361-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] Photodynamic Therapyによる胆管癌外科切除後治療2011
- Author(s)
  七島篤志、野中隆、磯本一、上原雅隆、大仁田賢、阿保貴章、森崎智仁、植原亮平、澤井照光、中尾一彦、永安武
- Journal Title
  
  肝胆膵
  
  Volume: 62巻6号 Pages: 1121-1129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591777
[Journal Article] Enhanced Expression of CXCL13 in Human Helicobacter pylori-Associated Gastritis2011
- Author(s)
  Nakashima Y, Isomoto H, Matsushima K, Yoshida A, Nakayama T, Nakayama M, Hisatsune J, Ichikawa T, Takeshima F, Hayashi T, Nakao K, Hirayama T, Kohno S
- Journal Title
  
  Dig Dis Sci
  
  Volume: 56 Pages: 2887-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] Advantages of laserphyrin compared with photofrin in photodynamic therapy for bile duct carcinoma2011
- Author(s)
  Takashi Nonaka, Atsushi Nanashima, Masataka Uehara, Hajime Isomoto, Yoshikazu Nonaka, Takeshi Nagayasu
- Journal Title
  
  J Hepatobiliary Pancreat Sci
  
  Volume: 18(4) Pages: 592-600
- NAID
  10029287797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591777
[Journal Article] MicroRNA signatures in Helicobacter pylori-infected gastric mucosa.2010
- Author(s)
  Matsushima K, Isomoto H, Inoue N, Nakayama T, Hayashi T, Nakayama M, Nakao K, Hirayama T, Kohno S.
- Journal Title
  
  Int J Cancer (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin,VacA.2010
- Author(s)
  Isomoto H, Moss J, Hirayama T.
- Journal Title
  
  Tohoku J. Exp. Med
  
  Volume: 220 Pages: 3-14
- NAID
  10027082787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA.2010
- Author(s)
  Isomoto H, Moss J, Hirayama T.
- Journal Title
  
  Tohoku J Exp Med. 220
  
  Pages: 3-14
- NAID
  10027082787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] MicroRNAs and esophageal squamous cell carcinoma2010
- Author(s)
  Matsushima K, Isomoto H, Kohno S, Nakao K
- Journal Title
  
  Digestion
  
  Volume: 82(3) Pages: 138-44
- Data Source
  KAKENHI-PROJECT-22590685
[Journal Article] Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA.2010
- Author(s)
  Isomoto H, et al.
- Journal Title
  
  Tohoku J Exp Med. 220
  
  Pages: 3-14
- NAID
  10027082787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA.2010
- Author(s)
  Isomoto H, et al.
- Journal Title
  
  Tohoku J Exp Med. 220
  
  Pages: 3-14
- NAID
  10027082787
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022039
[Journal Article] Analysis of apoptotic effects induced by photodynamic therapy in a human biliary cancer cell line2010
- Author(s)
  Takashi Nonaka, Atsushi Nanashima, Mihoko Nonaka, Masataka Uehara, Hajime Isomoto, Izumi Asahina, Takeshi Nagayasu
- Journal Title
  
  Anticancer Res
  
  Volume: 30(6) Pages: 2113-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591777
[Journal Article] ピロリ菌空胞化毒素の多機能性-感染における役割-2009
- Author(s)
  山崎栄樹, 磯本一, 平山壽哉
- Journal Title
  
  蛋白質核酸酵素 54
  
  Pages: 607-613
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] 外科的切除後断端陽性例に対するPhotodynamic therapyを併用した補助治療2009
- Author(s)
  七島篤志、飛永修一、野中隆、上原雅隆、磯本一、大仁田賢、角田順久、阿保貴章、澤井照光、安武亨、永安武
- Journal Title
  
  胆と膵
  
  Volume: 30(12) Pages: 1451-1456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591777
[Journal Article] 胆管癌のphotodynamic therapy2009
- Author(s)
  七島篤志、野中隆、上原雅隆、磯本一、飛永修一、角田順久、澤井照光、永安武
- Journal Title
  
  コンセンサス癌治療
  
  Volume: 8巻1号 Pages: 48-51
- Data Source
  KAKENHI-PROJECT-21591777
[Journal Article] 胆管癌に対するphotodynamic therapyの現況と将来.総説2009
- Author(s)
  七島篤志、野中隆、山口広之、飛永修一、澤井照光、上原雅隆、磯本一、永安武
- Journal Title
  
  日本レーザー医学会誌
  
  Volume: 30巻2号 Pages: 141-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591777
[Journal Article] Enhanced expression of CCL20 in human Helicobacter pylori-associated gastritis.2009
- Author(s)
  Yoshida A, Isomoto H, Hisatsune J, Nakayama M, Nakashima Y, Matsushima K, Mizuta Y, Hayashi T, Yamaoka Y, Azuma T, Moss J, Hirayama T, Kohno S.
- Journal Title
  
  Clin Immunol 130
  
  Pages: 290-297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] Photodynamic therapyを用いた非切除胆管癌治療の試み2009
- Author(s)
  七島篤志、飛永修一、磯本一、上原雅隆、野中美保子、林秀行、角田順久、阿保貴章、国崎真己、日高重和、竹下浩明、澤井照光、永安武
- Journal Title
  
  肝胆膵
  
  Volume: 59巻 Pages: 905-912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591777
[Journal Article] Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway.2009
- Author(s)
  Nakayama M, Hisatsune J, Yamasaki E, Isomoto H, Kurazono H, Hatakeyama M, Azuma T, Yamaoka Y, Yahiro K, Moss J, Hirayama T.
- Journal Title
  
  J Biol Chem. 284
  
  Pages: 1612-1619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] Molecular characterization of Helicobacter pylori VacA-induction of IL-8 in U937 cells reveals a prominent role for p38MAP kinase in ATF-2, CREB and NF-kB activation.2008
- Author(s)
  Hisatsune J, Nakayama M, Isomoto H. Kurazono H, Mukaida N, Mukhopadhyay AK, Azuma T, Yamaoka Y, Sap J, Yamasaki E, Yahiro K, Moss J, Hirayama T.
- Journal Title
  
  J. Immunol 180
  
  Pages: 5017-5027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] Synergic Effect of Photodynamic Therapy using Talaporfin Sodium with Conventional Anticancer Chemotherapy for the Treatment of Bile Duct Carcinoma
- Author(s)
  Yoshikazu Nonaka, Atsushi Nanashima, Takashi Nonaka, Masataka Uehara, Hajime Isomoto, Takafumi Abo, Takeshi Nagayasu
- Journal Title
  
  J Sur Research
  
  Volume: (revise中)
- NAID
  120006985888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591777
[Presentation] 上部消化管レーザー内視鏡を用いた胃腫瘍に対する光線力学的診断（PDD）2020
- Author(s)
  山下太郎，池淵雄一郎，坂口　啄紀, 神田努，菓裕貴，河口　剛一郎，八島一夫，萩原久美，松島加代子，中尾一，磯本一
- Organizer
  第16回日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-17K09475
[Presentation] 光線力学的診断（PDD）を可能にする上部消化管レーザー内視鏡2019
- Author(s)
  山下太郎，池淵雄一郎，神田努，吉田亮，河口剛一郎，八島一夫，荻原久美，松島加代子，中尾一彦，磯本一
- Organizer
  第32回日本レーザー医学会関西地方会
- Data Source
  KAKENHI-PROJECT-17K09475
[Presentation] 上部消化管レーザー内視鏡を用いた胃腫瘍に対する光線力学的診断（PDD）と, PDD の蛍光強度に影響を与える因子の基礎的検討2019
- Author(s)
  山下太郎，池淵雄一郎，神田努，菓裕貴，河口　剛一郎，八島一夫，萩原久美，松島加代子，中尾一彦，磯本一
- Organizer
  第39回日本レーザー医学会総会
- Data Source
  KAKENHI-PROJECT-17K09475
[Presentation] 胃癌を対象とした光線力学診断における臨床応用の取り組みと基礎的検討2019
- Author(s)
  山下太郎，池淵雄一郎，神田努，坂口　啄紀，木下英人，磯本一
- Organizer
  PhotoDynamic Medicine PDM 2019
- Data Source
  KAKENHI-PROJECT-17K09475
[Presentation] The molecular basis of Laser-based Photodynamic Endoscopic diagnosis for gastric tumors2017
- Author(s)
  Hiroki Kirumi, Kumi Ogihara, Hajime Isomoto
- Organizer
  DDW2017
- Place of Presentation
  McCormick Place, Chicago, IL, USA
- Year and Date
  2017-05-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461045
[Presentation] 細胞内GSH濃度がTalaporfin-PDTに与える影響についての検討．2017
- Author(s)
  荻原久美、松島加代子、山口直之、磯本一、中尾一彦
- Organizer
  第103回日本消化器内視鏡学会九州支部例会
- Data Source
  KAKENHI-PROJECT-15K21236
[Presentation] 胃癌に対するレーザー光線力学的診断の分子基盤2017
- Author(s)
  菓　裕貴, 荻原久美, 磯本　一
- Organizer
  日本消化管学会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2017-02-17
- Data Source
  KAKENHI-PROJECT-26461045
[Presentation] Expression of CPOX and PEPT1 Is Associated With Detection of Upper Gastrointestinal Carcinomas By 5-Aminolevlinic Acid Induced-Photodynamic Diagnosis.2016
- Author(s)
  Ogihara K, Isomoto H, Ishii H, Minami H, Akazawa Y, Yamaguchi N, Ohnita K, Takeshima F, Hidaka S, Matsushima K, Hashisako M, Tabata K, Nagayasu T, Fukuoka J, Nakao K
- Organizer
  Digestive Disease Week2016
- Place of Presentation
  サンディエゴ（米国）
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21236
[Presentation] ER STRESS CONTRIBUTES TO VAC A INDUCED GASTRIC EPITHERIAL CELL DEATH2012
- Author(s)
  Akazawa Y, H. Isomoto, K. Matsushima, K. Shiozawa, N. Yamaguchi, K. Ohnita, F. Takeshima, T. Hirayama, K. Nakao
- Organizer
  UEGW 2012
- Place of Presentation
  Amsterdam, Netherland.
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] Clinical significance of microRNAs in H.pylori-associated gastritis.2011
- Author(s)
  Kayoko Matsushima, Hajime Isomoto, Shigeru Kohno ,Yuko Akazawa ,Naoyuki Yamaguchi, Ken Ohnita, Tatsuki Ichikawa ,Fuminao Takeshima, Kazuhiko Nakano, Toshiya Hirayama
- Organizer
  The 8th Japan-Korea Joint Symposium on Helicobacter Infection
- Place of Presentation
  Seoul, Korea.
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] 食道癌の診断2011
- Author(s)
  南ひとみ, 磯本一, 中山敏幸, 松島加代子, 赤澤祐子, 山口直之, 大仁田賢, 竹島史直, 宿輪三郎, 林徳眞吉, 中尾一彦
- Organizer
  第92回日本消化器内視鏡学会九州支部例会
- Data Source
  KAKENHI-PROJECT-22590685
[Presentation] Mechanisms of H. pylori vacuolating cytotoxin-induced apoptosis in gastric epithelial cells2011
- Author(s)
  Hajime Isomoto, Kazuhiko Nakao,Kayoko Matsushima, Yuko Akazawa, Ayako Matsumoto,Toshiya Hirayama
- Organizer
  The 8th Japan-Korea Joint Symposium on Helicobacter Infection
- Place of Presentation
  Seoul, Korea.
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] 胆道癌細胞に対する新規光感受性物質(レザフィリン)による光線力学療法(PDT)の有用性の検討2010
- Author(s)
  野中隆、七島篤志, 飛永修一, 阿保貴章, 上原雅隆, 池田美保子, 磯本一, 永安武
- Organizer
  第22回日本肝胆膵外科学会・学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21591777
[Presentation] 胆道癌に対するPDTの現状と将来展望2010
- Author(s)
  七島篤志、野中隆, 磯本一, 上原雅隆, 阿保貴章, 森崎智仁, 澤井照光, 永安武
- Organizer
  日本レーザー医学会、シンポジウム
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-21591777
[Presentation] Enhanced expression of CCL20 and CXCL13 in Helicobacter pylori-associated gastritis in humans2010
- Author(s)
  Hajime Isomoto, Nakashima Y, Nakao K., Hirayama T
- Organizer
  XXIII International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
- Place of Presentation
  Rottterdam, The Netherland
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] Enhanced expression of CCL20 and CXCL13 in Helicobacter pylori-associated gastritis in humans2010
- Author(s)
  Isomoto H., et al.
- Organizer
  XXIII International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
- Place of Presentation
  Rotterdam, The Netherlands
- Year and Date
  2010-09-16
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] Enhanced expression of CCL20 and CXCL13 in Helicobacter pylori-associated gastritis in humans2010
- Author(s)
  Isomoto H., et al.
- Organizer
  XXIII International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
- Place of Presentation
  Rottterdam, The Netherland
- Year and Date
  2010-09-16
- Data Source
  KAKENHI-PUBLICLY-21022039
[Presentation] 新規光感受性物質を用いた胆道癌への光線力学療法-従来のフォトフリンとの比較解析2010
- Author(s)
  野中良和、野中隆, 七島篤志, 阿保貴章, 上原雅隆, 池田美保子, 磯本一, 澤井照光, 永安武
- Organizer
  第48回日本癌治療学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21591777
[Presentation] 光感受性物質レザフィリンとフォトフリンを用いた胆道癌への光線力学療法の比較解析2010
- Author(s)
  野中隆、七島篤志, 上原雅隆, 池田美保子, 磯本一, 永安武
- Organizer
  第20回日本光線力学学会学術講演会
- Place of Presentation
  福井
- Data Source
  KAKENHI-PROJECT-21591777
[Presentation] ヒト由来胆道癌細胞に対するフォトフリンによる光線力学療法(PDT)の殺細胞効果、アポトーシス誘導効果の検討2009
- Author(s)
  野中隆、七島篤志、上原雅隆、池田美保子、磯本一、永安武
- Organizer
  第19回日本光線力学学会総会
- Place of Presentation
  横浜
- Year and Date
  2009-07-04
- Data Source
  KAKENHI-PROJECT-21591777
[Presentation] Helicobacter pylori VacA induces GSK3 inhibition through the PI3K/Akt signaling pathway.2009
- Author(s)
  Toshiya Hirayama, Masaaki Nakayama, Hajime Isomoto, Masanori Hatakeyama, Takeshi Azuma, Yoshio Yamaoka, Joel Moss
- Organizer
  XXII International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
- Place of Presentation
  Porto, Portugal
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] 胆管癌の局所補助療法としての光線力学的療法の試みと今後の課題2009
- Author(s)
  野中隆、七島篤志、上原雅隆、池田美保子、磯本一、澤井照光、竹下浩明、日高重和、福岡秀敏、國崎真己、荒木政人、永安武
- Organizer
  第109回日本外科学会定期学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21591777
[Presentation] miRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells2009
- Author(s)
  松島加代子・磯本一, 他
- Organizer
  Gastro2009
- Place of Presentation
  ロンドン
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-19590728
[Presentation] miRNA205とmiRNA 10aは食道扁平上皮癌に特異的マーカーである2009
- Author(s)
  磯本一, 松島加代子, 井上直樹
- Organizer
  第5回日本消化管学会
- Place of Presentation
  東京
- Year and Date
  2009-02-12
- Data Source
  KAKENHI-PROJECT-19590728
[Presentation] Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway.2009
- Author(s)
  Toshiya Hirayama, Masaaki Nakayama, Hajime Isomoto, Junzo Hisatsune, Shigeru Kohno, Eiki Yamasaki, Hisao Kurazono, Joel Moss
- Organizer
  109th General Meeting of American Society for Microbiology
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Helicobacter pylori VacA-induced IL-8 production in U937 cells is mediated by an increase in intracellular Ca2+ Junzou Hisatsune, Masaaki Nakayama, , followed by activation of ATF-2, CREB and NF-kB.2008
- Author(s)
  Toshiya Hirayama, Junzo Hisatsune, Kayo Matsushima, Hajime Isomoto, Shigeru Kohno, Hisao Kurazono, Joel Moss
- Organizer
  108th General Meeting of American Society for Microbiology
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Molecular Characterization of Helicobacter pylori VacA Induction of IL-8 in U937 Cells Reveals a Prominent Role for p38 MAPK in ATF-2, CREB Protein, and NF-kB Activation.2008
- Author(s)
  Hajime Isomoto, Toshiya Hirayama
- Organizer
  The 9th Korea-Japan International Symposium on Microbiology
- Place of Presentation
  Soul, Korea
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] HELICOBACTER PYROLI VACA ENHANCES PGE2 PRODUCTION THROUGH INDUCTION OF COX-2 EXPRESSION VIA p38 MAP KINASE/ATF-2 CASCADE IN AZ-521 CELLS.2008
- Author(s)
  Hajime Isomoto, Joel Moss, Toshiya Hirayama
- Organizer
  7th China-Korea-Japan Joint Conference on Helicobacter Infection
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Helicobacter pylori VacA increases IL-8 production by p38 MAPK activation via intracellular Ca 2+-release, leading to ATF-2, CREB and NF-kB activation2008
- Author(s)
  Toshiya Hirayama, Junzo Hisatsune, Hisao Kurazono, Hajime Isomoto, Joel Moss
- Place of Presentation
  Istanbul, Turkey
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Pleotropic action of Helicobacter pylori vacuolating cytotoxin, VacA, on esophageal cell types2007
- Author(s)
  Isomoto H, et. al.
- Organizer
  47 th Annual Meeting The American Society for Cell Biology
- Place of Presentation
  Washington, DC, USA
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Pleotropic action of Helicobacter pylori vacuolating cytotoxin, VacA on esophageal cell types.2007
- Author(s)
  Hajime Isomoto
- Organizer
  The American Society for Cell Biology 48th Annual Meeting
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Pleotropic action of Helicobacter pylori vacuolating cytotoxin. VacA, on esophageal cell types2007
- Author(s)
  Isomoto H, et. al.
- Organizer
  47 th Annual Meeting The American Society for Cell Biology
- Place of Presentation
  Washington, DC, USA
- Data Source
  KAKENHI-PROJECT-19041060

1. HIRAYAMA Toshiya (50050696)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
2. NANASHIMA Atsushi (60380838)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
3. NAGAYASU Takeshi (80284686)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
4. 山口直之 (40457560)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. UEHARA Masataka (10253684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
6. HIRANO Tooru (30313951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OHTSURU Akira (00233198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. MAKASHIMA Masahiro (50284683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. YOSHIMOTO Hiroshi (90513309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HIYOSHI Masahide (60381117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YANO Koichi (30627344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ABO Takahumi (70404267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MAKIYAMA Kazuya (70112381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MATSUSHIMA Kayoko (90404293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
15. UEKI Masaru (60542256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 村瀬邦彦 (30274640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 山崎栄樹 (40514708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 近藤克哉 (00295750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 上原一剛 (10324998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 高橋洋一 (40594271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 藤井政至 (40762258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 三好雅之 (60632966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 古賀敦朗 (90563891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 赤司太郎 (20975833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 羽場宏光 (60360624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 斧山巧 (60817831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 野村幸世 (70301819)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 熊倉嘉貴 (90517773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 八島一夫 (80314590)

# of Collaborated Projects: 1 results

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30. 坂口琢紀 (90835258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. TSUZIMURA Noriyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. OGIHARA Kumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

ISOMOTO Hajime 磯本 一

ISOMOTO Hazime 磯本 一

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establishment of novel imaging using LCTF for gastrointestinal cancerPrincipal Investigator

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Molecular basis for clinical cancer stem cell targeted photodynamic therapyPrincipal Investigator

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Clinical significance of esophageal squamous cell carcinoma-specific microRNA in circulation and tissuePrincipal Investigator

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Clinical significance and regulatory mechanisms of Mcl-1 in esophageal squamous cell carcinomaPrincipal Investigator

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ISOMOTO Hajime 磯本一

ISOMOTO Hazime 磯本一