Kuwabara Atsushi 桑原敦志

… Alternative Names

KUWABARA ATSUSHI 桑原敦志

KUWABARA Atsushi 桑原敦志

Less

Researcher Number	90323344
Other IDs
Affiliation (Current)	2025: 高崎健康福祉大学, 保健医療学部, 教授
Affiliation (based on the past Project Information) *help	2013 – 2014: 高崎健康福祉大学, 保健医療学部, 教授 2010 – 2011: 高崎健康福祉大学, 保健医療学部, 准教授 2007 – 2009: Gunma University, 医学部, 助教 2003 – 2006: 群馬大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Laboratory medicine / Orthopaedic surgery Except Principal Investigator Laboratory medicine
Keywords	Principal Investigator スフィンゴシン1-リン酸 / 動脈硬化 / lipoprotein / Atherosclerosis / HDL-cholesterol / sphinaosine 1-phosphate / LDLコレステロール / リポタンパク / 甲状腺ホルモン / 脂質代謝 … More / リポ蛋白質 / HDLコレステロール / pH感知性受容体 / 関節リウマチ / プロトン受容体 / GPR4 / Imidazopyridine化合物 / コラーゲン関節リウマチモデル / SlP / LPA / S1P / リゾホスファチジン酸 / HDL / LDL / 冠動脈疾患 / リポ蛋白 / リゾフォスファチジン酸 / スフィンゴシン1リン酸 … More Except Principal Investigator Autoimmunity / Iodothyronine Deiodinase / Thyroid Stimulating Hormone / Hypothyroidism / 自己免疫 / 脱ヨード酵素 / 甲状腺刺激ホルモン / 甲状腺機能低下症 Less

Analysis of the role of pH-sensing receptors in arthritis using receptor-deficient micePrincipal Investigator
- Principal Investigator
  
  KUWABARA ATSUSHI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Takasaki University of Health and Welfare
Lysophospholipid signal molecules act as determinants of conflicting actions of the lipoproteins.Principal Investigator
- Principal Investigator
  
  KUWABARA Atsushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Takasaki University of Health and Welfare
  Gunma University
The change of lysophospholipid balance in the lipoprotein is a new biomarker for the coronary artery diseasePrincipal Investigator
- Principal Investigator
  
  KUWABARA Atsushi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Gunma University
Study on novel molecular mechanisms for thyroid dysfunction
- Principal Investigator
  
  MURAKAMI Masami
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Gunma University
Mesurements of extracellular concentratin change of sphingosine 1-phosphate, lipid mediator, are useful to clinical procedure of the atherogenic diseasePrincipal Investigator
- Principal Investigator
  
  KUWABARA Atsushi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Gunma University

All 2010 2009 2008 2007 2006 2005 2004 2003

All Journal Article Presentation

[Journal Article] Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells.2010
- Author(s)
  Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F.
- Journal Title
  
  J Biol Chem. 285(7)
  
  Pages: 4387-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590610
[Journal Article] Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells2010
- Author(s)
  DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F
- Journal Title
  
  J Biol Chem
  
  Volume: 285(7) Pages: 4387-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590610
[Journal Article] LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites.2009
- Author(s)
  Komachi M, Tomura H, Malchinkhuu E, Tobo M, Mogi C, Yamada T, Kimura T, Kuwabara A Ohta H, Im DS, Kurose H, Takevoshi I, SatoK. Okaiima F.
- Journal Title
  
  Carcinogenesis. 30(3 )
  
  Pages: 457-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590521
[Journal Article] LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibitionof migration of pancreatic cancer cells in response tolysophosphatidic acid and malignant ascites2009
- Author(s)
  Komachi M, Tomura H, Malchinkhuu E, Tobo M, Mogi C, Yamada T, Kimura T, Kuwabara A, Ohta H, Im DS, Kurose H, TK, Okajima F
- Journal Title
  
  Carcinogenesis 30(3)
  
  Pages: 457-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590521
[Journal Article] Induction of scavenger receptor class B tylpe I is critical for simvastat in enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells.2008
- Author(s)
  Kimura T, Mogi C, Tomura H, Kuwabara A, Im DS, Sato K, Kurose H, Murakami M, Okajima F.
- Journal Title
  
  J Immunology 181(10)
  
  Pages: 7332-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590521
[Journal Article] Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells2008
- Author(s)
  Kimura T, Mogi C, Tomura H,Kuwabara A, Im DS, Sato K, Kurose H, Murakami M, Okajima F
- Journal Title
  
  J Immounol Nov15 181(10)
  
  Pages: 7332-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590521
[Journal Article] HDL-like lipoproteins in cerebrospinal fluid affeneural cell activity throughlipoprotein miqratory associated sphingosine 1-phosphate2007
- Author(s)
  Sato K, Malchinkhuu E, Horiuchi Y, Mogi Tomura H, Tosaka M, Yoshimoto Y, Kuwabara A, Okajima F
- Journal Title
  
  Biochem Biophys Res Commun 3 ; 359(3)
  
  Pages: 649-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590521
[Journal Article] Role of lipoprotein-associated lysophospholipids in mactivity of coronary artery smooth muscle cells2007
- Author(s)
  Damirin A, Tomura H, Komachi M, Liu JP, Mogi C, Tobo M, Wang JQ, Kimura T, Kuwabara A, Yamazaki Y, Ohta H, Im DS, Sato K, Okajima F
- Journal Title
  
  Am J Physiol Heart Cire Physiol 295(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590521
[Journal Article] Role of lipoprotein-associated lysqphospbolipids in migratory activity of coronary artery smooth muscle cells2007
- Author(s)
  Damirin A, Tomura H, Komachi M, Liu JP, Mogi C, Tobo M, Wang JQ, Kimura T, Kuwabara A, Yamazaki Y, Ohta H, Im DS, Sato K, Okajima F
- Journal Title
  
  Am J Physiol Heart Circ Physiol 292(5)
  
  Pages: 2513-2522
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590521
[Journal Article] Critical role of ABCA1 transporter in sphilgosine 1-phosphate release from astrocytes2007
- Author(s)
  Sato K, Malchinkhuu E, Horiuchi Y, Mogi C, Tomura H, Tosaka M, Yoshimoto Y, Kuwabara A, Okajima F
- Journal Title
  
  J Neurochem (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590521
[Journal Article] Sphingosine 1-phosphate receptors mediate stimulatory and inhibitory signalings for expression of adhesion molecules in endothelial cells2006
- Author(s)
  Kimura T, Tomura H, Mogi C, Kuwabara A, Ishiwara M, Shibasawa K, Sato K, Ohwada S, Im DS, Kurose H, Ishizuka T, Murakami M, Okajima F
- Journal Title
  
  Cell Signal Jun ; 18(6)
  
  Pages: 841-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590521
[Journal Article] Sphingosine 1-phosphate receptors mediate stimulatory and inhibitory signalings for expression of adhesion molecules in endothelial cells2006
- Author(s)
  Kimura T, Tomura H, Mogi C, Kuwabara A, Ishiwara M, Shibasawa K, Sato K, Ohwada S, Im DS, Kurose H, Ishizuka T, Murakami M, Okajima F
- Journal Title
  
  Cell Signal. 18
  
  Pages: 841-850
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590479
[Journal Article] Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high density lipoprotein-inducedinhibition of adnesion molecule expression in endothelial2006
- Author(s)
  Kimura T, Tomura H, Mogi C, Kuwabara A, Damirin A, Ishizuka T, Sekiguchi A, Ishiwara M, Im DS Sato K, Murakami M, Okajima F
- Journal Title
  
  J Biol Chem Dec8 ; 281(49)
  
  Pages: 37457-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590521
[Journal Article] Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high density lipoprotein-induced inhibition of molecule expression in endothelial cells.2006
- Author(s)
  Kimura T, Tomura H, Mogi C, Kuwabara A, Damirin A, Ishizuka T, Sekiguchi A, Ishiwara M, Im DS, Sato K, Murakami M, Okajima F
- Journal Title
  
  J Biol Chem 281(49)
  
  Pages: 37457-67
- Data Source
  KAKENHI-PROJECT-18590521
[Journal Article] Sphingosine 1-phosphate receptors mediate stimulatory and inhibitory signalings for expression of adhesion molecules in endothelial cells.2006
- Author(s)
  Kimura T, Tomura H, Mogi C, Kuwabara A, Ishiwara M, Shibasawa K, Sato K, Ohwada S, Im DS, Kurose H, Ishizuka T, Murakami M, Okajima F.
- Journal Title
  
  Cellular Signaling 18
  
  Pages: 841-850
- Data Source
  KAKENHI-PROJECT-15590479
[Journal Article] Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins.2005
- Author(s)
  Zhang B, Tomura H, Kuwabara A, Kimura T, Miura S, Noda K, Okajima F, Saku K.
- Journal Title
  
  Atherosclerosis 178(1)
  
  Pages: 199-205
- Data Source
  KAKENHI-PROJECT-15590479
[Journal Article] High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component.2005
- Author(s)
  Tamama K, Tomura H, Sato K, Malchinkhuu E, Damirin A, Kimura T, Kuwabara A, Murakami M, Okajima F
- Journal Title
  
  Atherosclerosis. 178(1)
  
  Pages: 19-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590479
[Journal Article] High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component.2005
- Author(s)
  Tamama K, Tomura H, Sato K, Malchinkhuu E, Damirin A, Kimura T, Kuwabara A, Murakami M, Okajima F.
- Journal Title
  
  Atherosclerosis. 178(1)
  
  Pages: 19-23
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590479
[Journal Article] Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins.2005
- Author(s)
  Zhang B, Tomura H, Kuwabara A, Kimura T, Miura S, Noda K, Okajima F, Saku K.
- Journal Title
  
  Atherosclerosis. 178(1)
  
  Pages: 199-205
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590479
[Journal Article] Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins.2005
- Author(s)
  Zhang B, Tomura H, Kuwabara A, Kimura T, Miura S, Noda K, Okajima F, Saku K
- Journal Title
  
  Atherosclerosis. 178(1)
  
  Pages: 199-205
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590479
[Journal Article] High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component.2005
- Author(s)
  Tamama K, Tomura H, Sato K, Malchinkhuu E, Damirin A, Kimura T, Kuwabara A, Murakami M, Okajima F.
- Journal Title
  
  Atherosclerosis 178(1)
  
  Pages: 19-23
- Data Source
  KAKENHI-PROJECT-15590479
[Journal Article] TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor.2004
- Author(s)
  Wang JQ, Kon J, Mogi C, Tobo M, Damirin A, Sato K, Komachi M, Malchinkhuu E, Murata N, Kimura T, Kuwabara A, Wakamatsu K, Koizumi H, Uede T, Tsujimoto C, Kurose H, Sato T, Harada A, Misawa N, Tomura H, Okajima F
- Journal Title
  
  J Biol Chem. 279(44)
  
  Pages: 45626-45633
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590479
[Journal Article] Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.2004
- Author(s)
  Yamada T, Sato K, Komachi M, Malchinkhuu E, Tobo M, Kimura T, Kuwabara A, Yanagita Y, Ikeya T, Tanahashi Y, Ogawa T, Ohwada S, Morishita Y, Ohta H, ImDS, Tamoto K, Tomura H, Okajima F.
- Journal Title
  
  J Biol Chem. 279(8)
  
  Pages: 6595-605
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590479
[Journal Article] Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells throuah LPA1.2004
- Author(s)
  Yamada T, Sato K, Komachi M, Malchinkhuu E, Tobo M, Kimura T, Kuwabara A, Yanagita Y, Ikeya T, Tanahashi Y, Ogawa T, Ohwada S, Morishita Y, Ohta H, Im DS, Tamoto K, Tomura H, Okajima F
- Journal Title
  
  J Biol Chem. 279(8)
  
  Pages: 6595-6605
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590479
[Journal Article] High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors2003
- Author(s)
  Kimura T, Sato K, Malchinkhuu E, Tomura H, Tamama K, Kuwabara A, Murakami M, Okajima F
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 23(7)
  
  Pages: 1283-1288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590479
[Journal Article] High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors.2003
- Author(s)
  Kimura T, Sato K, Malchinkhuu E, Tomura H, Tamama K, Kuwabara A, Murakami M, Okajima F.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 23(7)
  
  Pages: 1283-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590479
[Journal Article] Assessment of the role of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroglial cell function.2003
- Author(s)
  Malchinkhuu E, Sato K, Muraki T, Ishikawa K, Kuwabara A, Okajima F.
- Journal Title
  
  Biochem J. 370
  
  Pages: 817-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590479
[Journal Article] Assessment of the role of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroalial cell function.2003
- Author(s)
  Malchinkhuu E, Sato K, Muraki T, Ishikawa K, Kuwabara A, Okajima F
- Journal Title
  
  Biochem J. 370(Pt 3)
  
  Pages: 817-827
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590479
[Presentation] HDLの血管内皮細胞保護作用に対するLDLの作用の解析2010
- Author(s)
  桑原敦志、木村孝穂他
- Organizer
  第57回日本臨床検査医学会学術集会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2010-09-12
- Data Source
  KAKENHI-PROJECT-21590610

1. OKAJIMA Fumikazu (30142748)

# of Collaborated Projects: 3 results

# of Collaborated Products: 27 results
2. MURAKAMI Masami (30241871)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. OGIWARA Takayuki (80361377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kuwabara Atsushi 桑原 敦志

KUWABARA ATSUSHI 桑原 敦志

KUWABARA Atsushi 桑原 敦志

Research Projects

Research Products

Co-Researchers

Analysis of the role of pH-sensing receptors in arthritis using receptor-deficient micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Lysophospholipid signal molecules act as determinants of conflicting actions of the lipoproteins.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The change of lysophospholipid balance in the lipoprotein is a new biomarker for the coronary artery diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on novel molecular mechanisms for thyroid dysfunction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mesurements of extracellular concentratin change of sphingosine 1-phosphate, lipid mediator, are useful to clinical procedure of the atherogenic diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells.2010

Author(s)

Journal Title

Data Source

[Journal Article] Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells2010

Author(s)

Journal Title

Data Source

[Journal Article] LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites.2009

Author(s)

Journal Title

Data Source

[Journal Article] LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibitionof migration of pancreatic cancer cells in response tolysophosphatidic acid and malignant ascites2009

Author(s)

Journal Title

Data Source

[Journal Article] Induction of scavenger receptor class B tylpe I is critical for simvastat in enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells.2008

Author(s)

Journal Title

Data Source

[Journal Article] Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells2008

Author(s)

Journal Title

Data Source

[Journal Article] HDL-like lipoproteins in cerebrospinal fluid affeneural cell activity throughlipoprotein miqratory associated sphingosine 1-phosphate2007

Author(s)

Journal Title

Data Source

[Journal Article] Role of lipoprotein-associated lysophospholipids in mactivity of coronary artery smooth muscle cells2007

Author(s)

Journal Title

Data Source

[Journal Article] Role of lipoprotein-associated lysqphospbolipids in migratory activity of coronary artery smooth muscle cells2007

Author(s)

Journal Title

Data Source

[Journal Article] Critical role of ABCA1 transporter in sphilgosine 1-phosphate release from astrocytes2007

Author(s)

Journal Title

Data Source

[Journal Article] Sphingosine 1-phosphate receptors mediate stimulatory and inhibitory signalings for expression of adhesion molecules in endothelial cells2006

Author(s)

Journal Title

Data Source

Kuwabara Atsushi 桑原敦志

KUWABARA ATSUSHI 桑原敦志

KUWABARA Atsushi 桑原敦志