Kobayashi Kazuhiro 小林千浩

… Alternative Names

KOBAYASHI Kazuhiro 小林千浩

小林千浩コバヤシカズヒロ

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Researcher Number	90324780
Other IDs	https://orcid.org/0000-0001-7801-147X
Affiliation (Current)	2025: 神戸大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 神戸大学, 医学研究科, 准教授 2012 – 2015: 神戸大学, 医学(系)研究科(研究院), 准教授 2014: 神戸大学, 医学研究科, 准教授 2014: 神戸大学, 大学院医学研究科分子脳科学, 准教授 2014: 神戸大学, 大学院医学研究科, 准教授 … More 2013: 神戸大学, 大学院・医学研究科, 教授 2009 – 2012: Kobe University, 医学研究科, 准教授 2007: Osaka University, 医学系研究科, 助教 2004: 阪大, 医学(系)研究科(研究院), 助手 2001 – 2003: 大阪大学, 医学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Pediatrics / Cognitive science / Basic Section 52020:Neurology-related / Human genetics / Neurology / Biological Sciences Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Neurology / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 10020:Educational psychology-related … More / Broad Section G / Basic Section 52050:Embryonic medicine and pediatrics-related / Educational psychology / Pediatrics / Biological Sciences Less
Keywords	Principal Investigator 糖鎖 / 福山型筋ジス / 糖転移酵素 / POMGnT1 / フクチン / muscle-eye-brain病 / 遺伝子 / 脳神経疾患 / 筋ジストロフィー / fukutin … More / α-dystroglycan / ジストログリカノパチー / マイクロアレイ / CNV / 知能 / 認知 / エピジェネティクス / ゲノム脳科学 / 遺伝子治療 / モデルマウス / アンチセンス核酸 / リビトールリン酸 / 治療 / 酵素 / muscle-eye-brain disease / knock-in mouse / retrotransposon / glycosyltransferase / antibody / Fukuyama muscular dystrophy / ノックインマウス / レトロトランスポゾン / 抗体 / 神経機能障害 / a-dystroglycan / NMR構造解析 / 質量分析 / 福山型筋ジストロフィー / 行動解析 / 精神遅滞 / 双生児 / 次世代シークエンサー / DNAメチル化 / 遺伝子発現 / 精神発達遅滞 / 脳認知科学 / ゲノム / 高次脳機能 / 筋眼脳病 / 小児神経学 / 神経細胞移動 / KIAA0319 / ディスレキシア / POMGnTl / コンディショナルノックアウトマウス / キメラマウス … More Except Principal Investigator 福山型筋ジストロフィー / アンチセンス核酸 / 筋ジストロフィー / 分子標的治療 / ジストログリカン / AAV遺伝子治療 / 糖鎖 / リビトールリン酸異常症 / 脳画像 / 認知能力 / 行動遺伝学 / 遺伝と環境 / 双生児法 / スプライシング異常 / RNA創薬 / 先天性筋ジストロフィー / アンチセンス治療 / ジストログリカノパチー / 有機合成化学 / 抗体医療 / リビトールリン酸 / 不一致一卵性 / 縦断研究 / エピジェネティック / 主観的幸福感 / ストレスフルライフイベント / 実行機能 / 利他性 / 教育動機 / うつ / パーソナリティ / 自尊心 / 福山型金ジストロフィー / リビトール補充療法 / 糖アルコール / 中枢奇形 / 中枢奇形を伴う筋ジストロフィー / バイオマーカー検索 / 糖鎖異常 / 疾患モデル / バイオマーカー / 低分子化合物 / 創薬開発 / メンタルヘルス / 縦断コホート研究 / 双生児 / fMRI / 脳機能 / 成人期 / 児童期 / 脳・神経 / 遺伝学 / 教育系心理学 / 学業達成 / 発達 / 教育 / 社会性発達 / 認知発達 / エピジェネティクス / 分子遺伝学 / 脳神経科学 / ドラッグデリバリーシステム / 核酸治療 / ポストリン酸構造 / フクチン / レトロトランスポゾン / 次世代シークエンサー / 次世代シーケンサー / 多型 / 認知機能 / パーキンソン病 / パーソナルゲノム Less

ラミニン結合性機能糖鎖を応用した筋ジストロフィーに対する創薬研究
- Principal Investigator
  
  遠藤玉夫
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
福山型筋ジス及びDG異常症のアンチセンス核酸、糖鎖補充、AAV治療、胎児治療開発
- Principal Investigator
  
  戸田達史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  The University of Tokyo
福山型筋ジストロフィーおよび類縁疾患の病態解析と治療法・薬効評価法の開発Principal Investigator
- Principal Investigator
  
  小林千浩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kobe University
Pathogenesis and Antisense nucleic acid, glycosylation supplementation, and AAV therapy development forFukuyama muscular dystrophy and related diseases
- Principal Investigator
  
  TODA Tatsushi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  The University of Tokyo
Biology of sugar-alcohol modification in glycan
- Principal Investigator
  
  Endo Tamao
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section G
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Central Nervous System Involvement of Fukuyama type muscular dystrophy
- Principal Investigator
  
  Ikeda Mariko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Fujita Health University
Developmental behavioral genetic study of educational processes and their outcome by the twin method.
- Principal Investigator
  
  Ando Juko
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 10020:Educational psychology-related
- Research Institution
  Keio University
Elucidation of pathomecanism for Fukuyama muscular dystrophy and dystroglycanopathy and their drug developmen
- Principal Investigator
  
  Toda Tatsushi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo
  Kobe University
Investigation of molecular pathogenesis and development of therapeutic methods for Fukuyama muscular dystrophy and related diseasesPrincipal Investigator
- Principal Investigator
  
  Kobayashi Kazuhiro
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Integrated behavioral genetic study of educational processes.
- Principal Investigator
  
  Ando Juko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Educational psychology
- Research Institution
  Keio University
Analysis of the causative glycan for muscular dystrophy and exploration of the therapeutic possibility of its neuronal dysfunctionPrincipal Investigator
- Principal Investigator
  
  Kobayashi Kazuhiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Identifying the genetic basis and understanding the molecular mechanisms underlying cognitive functionPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Kazuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cognitive science
- Research Institution
  Kobe University
Antisense oligonucleotide therapy for Fukuyama type congenital muscular dystrophy
- Principal Investigator
  
  TANIGUCHI-IKEDA Mariko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
Molecular targeting therapy and pathomechanism for Fukuyama muscular dystrophy and related disorders
- Principal Investigator
  
  TATSUSHI Toda
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Kobe University
Molecular analyses of genes related to cognitive abilities.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Kazuhiro
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cognitive science
- Research Institution
  Kobe University
Personal genome analysis of genes for Parkinson's disease and cognitive function
- Principal Investigator
  
  TODA Tatsushi
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Elucidation of molecular pathogenesis and development of treatment for muscular dystrophy and neurodevelopmental disorder caused by abnormal glycosylationPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Kazuhiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Pediatrics
- Research Institution
  Kobe University
神経細胞での筋ジストロフィー原因遺伝子産物の機能とディスレキシアとの共通発症機構Principal Investigator
- Principal Investigator
  
  小林千浩
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
神経細胞移動障害を伴う先天性筋ジストロフイーの分子遺伝子学的病態解析Principal Investigator
- Principal Investigator
  
  小林千浩
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
糖鎖異常による先天性筋ジストロフイーの分子生物学的病態解析Principal Investigator
- Principal Investigator
  
  小林千浩
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Molecular analysis of Fukuyama muscular dystrophy and functional analysis of the gene product fukutin.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Kazuhiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Osaka University

[Journal Article] Endogenous reductase activities for the generation of ribitol-phosphate, a CDP-ribitol precursor, in mammals2023
- Author(s)
  Hoshino Shunsuke、Manya Hiroshi、Imae Rieko、Kobayashi Kazuhiro、Kanagawa Motoi、Endo Tamao
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 175 Issue: 4 Pages: 418-425
- DOI
  10.1093/jb/mvad115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06110, KAKENHI-PROJECT-19H05648, KAKENHI-PROJECT-21H02685, KAKENHI-PROJECT-23K24244, KAKENHI-PROJECT-23K27328
[Journal Article] CDP-ribitol prodrug treatment ameliorates ISPD-deficient muscular dystrophy mouse model2022
- Author(s)
  Tokuoka Hideki、Imae Rieko、Nakashima Hitomi、Manya Hiroshi、Masuda Chiaki、Hoshino Shunsuke、Kobayashi Kazuhiro、Lefeber Dirk J.、Matsumoto Riki、Okada Takashi、Endo Tamao、Kanagawa Motoi、Toda Tatsushi
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 1847-1847
- DOI
  10.1038/s41467-022-29473-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03987, KAKENHI-PROJECT-22K19509, KAKENHI-PROJECT-20H00526, KAKENHI-PROJECT-21H02685, KAKENHI-PROJECT-19K07058, KAKENHI-WRAPUP-22H04899, KAKENHI-PROJECT-23K20328, KAKENHI-PROJECT-19H05648, KAKENHI-PROJECT-23K24244
[Journal Article] Comparative whole transcriptome analysis of Parkinson’s disease focusing on the efficacy of zonisamide2022
- Author(s)
  Naito Tatsuhiko、Satake Wataru、Cha Pei-Chieng、Kobayashi Kazuhiro、Murata Miho、Toda Tatsushi
- Journal Title
  
  Journal of Neurology, Neurosurgery & Psychiatry
  
  Volume: NA Issue: 5 Pages: 509-512
- DOI
  10.1136/jnnp-2021-328742
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J12189, KAKENHI-PROJECT-20H00526, KAKENHI-PROJECT-23K24244
[Journal Article] TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 22022
- Author(s)
  Egawa Naohiro, Seki Tsuneyoshi, Kobayashi Kazuhiro, Toda Tatsushi, Inoue Haruhisa, et al
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 12133-4
- DOI
  10.1038/s41598-022-12133-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15697, KAKENHI-PROJECT-20K22874, KAKENHI-PROJECT-20H00526, KAKENHI-PROJECT-20K07883, KAKENHI-PROJECT-23K24244
[Journal Article] Genetic variations and clinical spectrum of dystroglycanopathy in a large cohort of Chinese patients2021
- Author(s)
  Song Danyu、Dai Yi、Chen Xiaoyu、Fu Xiaona、Chang Xingzhi、Wang Ning、Zhang Cheng、Yan Chuanzhu、Zheng Hong、Wu Liwen、Jiang Li、Hua Ying、Yang Haipo、Wang Zhiqiang、Dai Tingjun、Zhu Wenhua、Han Chunxi、Yuan Yun、Kobayashi Kazuhiro、Toda Tatsushi、Xiong Hui
- Journal Title
  
  Clinical Genetics
  
  Volume: 99 Issue: 3 Pages: 384-395
- DOI
  10.1111/cge.13886
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00526
[Journal Article] Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain2021
- Author(s)
  Oguchi Mineki、Tanaka Shingo、Pan Xiaochuan、Kikusui Takefumi、Moriya-Ito Keiko、Kato Shigeki、Kobayashi Kazuto、Sakagami Masamichi
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1088-1088
- DOI
  10.1038/s42003-021-02623-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H01085, KAKENHI-PROJECT-20K06912
[Journal Article] Galectin 3?binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein2020
- Author(s)
  Seki Tsuneyoshi、Kanagawa Motoi、Kobayashi Kazuhiro、Kowa Hisatomo、Yahata Naoki、Maruyama Kei、Iwata Nobuhisa、Inoue Haruhisa、Toda Tatsushi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 11 Pages: 3678-3691
- DOI
  10.1074/jbc.ra119.008703
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07354, KAKENHI-PLANNED-17H06421, KAKENHI-PROJECT-16H05353, KAKENHI-PROJECT-19H00597
[Journal Article] Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy.2020
- Author(s)
  Kuwabara N, Imae R, Manya H, Tanaka T, Mizuno M, Tsumoto H, Kanagawa M, Kobayashi K, Toda T, Senda T, Endo T, Kato R.
- Journal Title
  
  Nat Commun.
  
  Volume: 11 Issue: 1 Pages: 303-303
- DOI
  10.1038/s41467-019-14220-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07058, KAKENHI-PLANNED-17H06421, KAKENHI-PROJECT-19H05648, KAKENHI-PROJECT-17H01563, KAKENHI-PROJECT-16H05353, KAKENHI-PROJECT-17H03987, KAKENHI-PROJECT-18H02616, KAKENHI-PROJECT-17H06264
[Journal Article] Triglyceride deposit cardiomyovasculopathy: a rare cardiovascular disorder2019
- Author(s)
  Li Ming、on behalf of the Japan TGCV study group、Hirano Ken-ichi、Ikeda Yoshihiko、Shimada Kazunori、et al.
- Journal Title
  
  Orphanet Journal of Rare Diseases
  
  Volume: 14 Issue: 1 Pages: 134-134
- DOI
  10.1186/s13023-019-1087-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01470, KAKENHI-PROJECT-16H05353, KAKENHI-PROJECT-17K09001
[Journal Article] Characterization of dystroglycan binding in adhesion of human induced pluripotent stem cells to laminin-511 E8 fragment2019
- Author(s)
  Sugawara Yumika、Hamada Keisuke、Yamada Yuji、Kumai Jun、Kanagawa Motoi、Kobayashi Kazuhiro、Toda Tatsushi、Negishi Yoichi、Katagiri Fumihiko、Hozumi Kentaro、Nomizu Motoyoshi、Kikkawa Yamato
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 1-12
- DOI
  10.1038/s41598-019-49669-x
- NAID
  120006728095
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06637, KAKENHI-PROJECT-18K12085, KAKENHI-PLANNED-17H06421, KAKENHI-PROJECT-19H05648, KAKENHI-PROJECT-17H01563, KAKENHI-PROJECT-16H05353, KAKENHI-PROJECT-18H02616, KAKENHI-PROJECT-18H02873, KAKENHI-PROJECT-17K01954, KAKENHI-PROJECT-17K07180
[Journal Article] Wide distribution of alpha-synuclein oligomers in multiple system atrophy brain detected by proximity ligation2019
- Author(s)
  Sekiya Hiroaki、Kowa Hisatomo、Koga Hinako、Takata Mariko、Satake Wataru、Futamura Naonobu、Funakawa Itaru、Jinnai Kenji、Takahashi Motonori、Kondo Takeshi、Ueno Yasuhiro、Kanagawa Motoi、Kobayashi Kazuhiro、Toda Tatsushi
- Journal Title
  
  Acta Neuropathologica
  
  Volume: 137 Issue: 3 Pages: 455-466
- DOI
  10.1007/s00401-019-01961-w
- NAID
  120006599160
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06421, KAKENHI-PROJECT-18H02616, KAKENHI-PROJECT-16H05353
[Journal Article] Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure2019
- Author(s)
  Ujihara Yoshihiro、Kanagawa Motoi、Mohri Satoshi、Takatsu Satomi、Kobayashi Kazuhiro、Toda Tatsushi、Naruse Keiji、Katanosaka Yuki
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 5754-5754
- DOI
  10.1038/s41467-019-13623-2
- NAID
  120006777089
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06421, KAKENHI-PROJECT-19H05648, KAKENHI-PROJECT-17H01563, KAKENHI-PROJECT-16H05353, KAKENHI-PROJECT-17H02085, KAKENHI-PROJECT-18H02616, KAKENHI-PROJECT-17H04740
[Journal Article] In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson’s disease2018
- Author(s)
  Uenaka Takeshi、Satake Wataru、Cha Pei-Chieng、Hayakawa Hideki、Baba Kousuke、Jiang Shiying、Kobayashi Kazuhiro、Kanagawa Motoi、Okada Yukinori、Mochizuki Hideki、Toda Tatsushi
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 27 Pages: 3974-3985
- DOI
  10.1093/hmg/ddy279
- NAID
  120006549191
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19512, KAKENHI-PUBLICLY-17H05700, KAKENHI-PLANNED-17H06421, KAKENHI-PROJECT-16H05353, KAKENHI-PROJECT-18H02616, KAKENHI-PROJECT-17H04056
[Journal Article] Newly developed selective immunoinactivation assay revealed reduction in adipose triglyceride lipase activity in peripheral leucocytes from patients with idiopathic triglyceride deposit cardiomyovasculopathy2018
- Author(s)
  Takagi Atsuko、Ikeda Yasuyuki、Kobayashi Kunihisa、Kobayashi Kazuhiro、Ikeda Yoshihiko、Kozawa Junji、Miyauchi Hideyuki、Li Ming、Hashimoto Chikako、Hara Yasuhiro、Yamaguchi Satoshi、Suzuki Akira、Toda Tatsushi、Nagasaka Hironori、Hirano Ken-ichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 1 Pages: 646-651
- DOI
  10.1016/j.bbrc.2017.11.070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05353
[Journal Article] CDP-glycerol inhibits the synthesis of the functionalO-mannosyl glycan of α-dystroglycan2018
- Author(s)
  Imae Rieko、Manya Hiroshi、Tsumoto Hiroki、Osumi Kenji、Tanaka Tomohiro、Mizuno Mamoru、Kanagawa Motoi、Kobayashi Kazuhiro、Toda Tatsushi、Endo Tamao
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 31 Pages: 12186-12198
- DOI
  10.1074/jbc.ra118.003197
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06421, KAKENHI-PROJECT-17H01563, KAKENHI-PROJECT-16H05353, KAKENHI-PROJECT-17H03987, KAKENHI-PROJECT-18H02616, KAKENHI-PROJECT-16K08262, KAKENHI-PROJECT-16K20996
[Journal Article] Cell endogenous activities of fukutin and FKRP coexist with the ribitol xylosyltransferase, TMEM5.2018
- Author(s)
  Nishihara, R., Kobayashi, K., Imae, R., Tsumoto, H., Manya, H., Mizuno, M., Kanagawa, M., Endo, T., and Toda, T.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 497 Issue: 4 Pages: 1025-1030
- DOI
  10.1016/j.bbrc.2018.02.162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08262, KAKENHI-PROJECT-16K20996, KAKENHI-PROJECT-26253057, KAKENHI-PROJECT-15H04352, KAKENHI-PLANNED-17H06421, KAKENHI-PROJECT-16H05353, KAKENHI-PROJECT-17H03987
[Journal Article] Temporal requirement of dystroglycan glycosylation during brain development and rescue of severe cortical dysplasia via gene delivery in the fetal stage2018
- Author(s)
  Sudo Atsushi、Kanagawa Motoi、Kondo Mai、Ito Chiyomi、Kobayashi Kazuhiro、Endo Mitsuharu、Minami Yasuhiro、Aiba Atsu、Toda Tatsushi
- Journal Title
  
  Human molecular genetics
  
  Volume: 27 Issue: 7 Pages: 1174-1185
- DOI
  10.1093/hmg/ddy032
- NAID
  120006459805
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25115010, KAKENHI-PROJECT-15H04352, KAKENHI-PLANNED-17H06421, KAKENHI-PROJECT-17H01563, KAKENHI-PROJECT-16H05152, KAKENHI-PROJECT-16H05353, KAKENHI-PROJECT-18H02616
[Journal Article] Deep-intronic variant of fukutin is the most prevalent point mutation of Fukuyama congenital muscular dystrophy in Japan2017
- Author(s)
  Kobayashi Kazuhiro、Kato Reiko、Kondo-Iida Eri、Taniguchi-Ikeda Mariko、Osawa Makiko、Saito Kayoko、Toda Tatsushi
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 62 Issue: 11 Pages: 945-948
- DOI
  10.1038/jhg.2017.71
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253057, KAKENHI-PROJECT-16H05353, KAKENHI-PROJECT-15K09621, KAKENHI-PROJECT-17H01563
[Journal Article] Novel FKRP mutations in a Japanese MDC1C sibship clinically diagnosed with Fukuyama congenital muscular dystrophy2017
- Author(s)
  Yoshioka Mieko、Kobayashi Kazuhiro、Toda Tatsushi
- Journal Title
  
  Brain and Development
  
  Volume: 39 Issue: 10 Pages: 869-872
- DOI
  10.1016/j.braindev.2017.05.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253057, KAKENHI-PROJECT-16H05353, KAKENHI-PROJECT-17H01563
[Journal Article] The muscular dystrophy gene TMEM5encodes a ribitol β1-4 Xylosyltransferase required for the functional glycosylation of dystroglycan.2016
- Author(s)
  Manya, H., Yamaguchi, Y., Kanagawa, M., Kobayashi, K., Tajiri, M., Akasaka-Manya, K., Kawakami, H., Mizuno, M., Wada, Y., Toda, T., and Endo, T.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 291 Issue: 47 Pages: 24618-24627
- DOI
  10.1074/jbc.m116.751917
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04352, KAKENHI-PROJECT-25460054, KAKENHI-PROJECT-16K08262, KAKENHI-PROJECT-26253057, KAKENHI-PROJECT-16H04758, KAKENHI-PROJECT-16H05353
[Journal Article] Carbohydrate-binding domain of the POMGnT1 stem region modulates O-mannosylation sites of α-dystroglycan.2016
- Author(s)
  Kuwabara N, Manya H, Yamada T, Tateno H, Kanagawa M, Kobayashi K, Akasaka-Manya K, Hirose Y, Mizuno M, Ikeguchi M, Toda T, Hirabayashi J, Senda T, Endo T, Kato R.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 113 Issue: 33 Pages: 9280-9285
- DOI
  10.1073/pnas.1525545113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253057, KAKENHI-PROJECT-15H04352, KAKENHI-PROJECT-16H05071, KAKENHI-PROJECT-16K18522, KAKENHI-PROJECT-16K07284, KAKENHI-PROJECT-16K08262, KAKENHI-PROJECT-16H05353
[Journal Article] Analysis of phenotype, enzyme activity, and genotype of Chinese patients with POMT1 mutation2016
- Author(s)
  Haipo Yang, Hiroshi Manya, Kazuhiro Kobayashi, HUI JIAO, Xiaona Fu, Jiangxi Xiao, Xiaoqing Li, Jingmin wang, Yuwu Jiang, TATSUSHI TODA, Tamao Endo, Xiru Wu,Hui Xiong,
- Journal Title
  
  J. Hum. Genet
  
  Volume: 印刷中 Issue: 8 Pages: 753-759
- DOI
  10.1038/jhg.2016.42
- NAID
  40020923851
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26110727, KAKENHI-PROJECT-16K08262, KAKENHI-PROJECT-26253057, KAKENHI-PROJECT-16H05353
[Journal Article] Identification of a post-translational modification with ribitol-phosphate and its defect in muscular dystrophy2016
- Author(s)
  Kanagawa M, Kobayashi K, Tajiri M, Manya H, Kuga A, Yamaguchi Y, Akasaka-Manya K, Furukawa J, Mizuno M, Kawakami H, Shinohara Y, Wada Y, Endo T, Toda T.
- Journal Title
  
  Cell Reports
  
  Volume: 14 Issue: 9 Pages: 2209-2223
- DOI
  10.1016/j.celrep.2016.02.017
- NAID
  120005728438
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-26110712, KAKENHI-PUBLICLY-26110727, KAKENHI-PROJECT-15H04352, KAKENHI-PROJECT-26670499, KAKENHI-PROJECT-25293016, KAKENHI-PROJECT-26253057, KAKENHI-PROJECT-25460054, KAKENHI-PROJECT-16H05353
[Journal Article] Fukutin is prerequisite to ameliorate muscular dystrophic phenotype by myofiber-selective LARGE expression.2015
- Author(s)
  Ohtsuka Y, Kanagawa M, Yu CC, Ito C, Chiyo T, Kobayashi K, Okada T, Takeda S’I, Toda T.
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 8316-8316
- DOI
  10.1038/srep08316
- NAID
  120005600773
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12F02422, KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-24500472, KAKENHI-PROJECT-24687017, KAKENHI-PUBLICLY-26110712, KAKENHI-PROJECT-26253057, KAKENHI-PROJECT-26670499, KAKENHI-PROJECT-26293328
[Journal Article] A de novo mutation of the MYH7 gene in a large Chinese family with autosomal dominant myopathy2015
- Author(s)
  Oda T, Xiong H, Kobayashi K, Wang S, Satake W, Jiao H, Yang Y, Cha PC, Hayashi Y, Nishino I, Suzuki Y, Sugano S, Wu X, Toda T.
- Journal Title
  
  Human Genome Variation
  
  Volume: 2 Issue: 1 Pages: 15022-15022
- DOI
  10.1038/hgv.2015.22
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12F02422, KAKENHI-PROJECT-26670499, KAKENHI-PROJECT-25713015, KAKENHI-PROJECT-26253057
[Journal Article] Founder mutation causes classical Fukuyama congenital muscular dystrophy (FCMD) in Chinese patients2015
- Author(s)
  Yang H, Kobayashi K, Wang S, Jiao H, Xiao J, Toda T, Wu X, Xiong H
- Journal Title
  
  Brain and Development
  
  Volume: 37 Issue: 9 Pages: 880-886
- DOI
  10.1016/j.braindev.2015.02.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670499
[Journal Article] Genetic mutations in adipose triglyceride lipase and myocardial up-regulation of peroxisome proliferated activated receptor-γ in patients with triglyceride deposit cardiomyovasculopathy.2014
- Author(s)
  Hirano K, Tanaka T, Ikeda Y, Yamaguchi S, Zaima N, Kobayashi K, Suzuki A, Sakata Y, Sakata Y, Kobayashi K, Toda T, Fukushima N, Ishibashi-Ueda H, Tavian D, Nagasaka H, Hui SP, Chiba H, Sawa Y, Hori M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 443 Issue: 2 Pages: 574-579
- DOI
  10.1016/j.bbrc.2013.12.003
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23617010
[Journal Article] Peripheral leukocyte anomaly detected with routine automated hematology analyzer sensitive to adipose triglyceride lipase deficiency manifesting neutral lipid storage disease with myopathy/triglyceride deposit cardiomyovasculopathy.2014
- Author(s)
  Suzuki A, Nagasaka H, Ochi Y, Kobayashi K, Nakamura H, Nakatani D, S Yamaguchi, Yamaki S, Wada A, Shirata Y, Hui SP, Toda T, Kuroda H, Chiba H, Hirano K.
- Journal Title
  
  Mol Genet Metab Rep
  
  Volume: 1 Pages: 249-253
- DOI
  10.1016/j.ymgmr.2014.05.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-23617010, KAKENHI-PROJECT-26253057
[Journal Article] Disease-associated marked hyperalphalipoproteinemia.2014
- Author(s)
  Hirano K, Nagasaka H, Kobayashi K, Yamaguchi S, Suzuki A, Toda T, Doyu M.
- Journal Title
  
  Mol Genet Metab Rep
  
  Volume: 1 Pages: 264-268
- DOI
  10.1016/j.ymgmr.2014.06.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-26253057
[Journal Article] 福山型筋ジストロフィー　遺伝子・病態の解明、分子標的治療を目指して2013
- Author(s)
  戸田達史, 谷口真理子(池田), 金川基, 小林千浩
- Journal Title
  
  生化学
  
  Volume: 85 Pages: 253-260
- NAID
  10031169565
- Data Source
  KAKENHI-PROJECT-23249049
[Journal Article] YY1 binds to α-synuclein 3'-flanking region SNP and stimulates antisense noncoding RNA expression.2013
- Author(s)
  Mizuta I, Takafuji K, Ando Y, Satake W, Kanagawa M, Kobayashi K, Nagamori S, Shinohara T, Ito C, Yamamoto M, Hattori N, Murata M, Kanai Y, Murayama S, Nakagawa M, Toda T.
- Journal Title
  
  J Hum Genet
  
  Volume: 58 Issue: 11 Pages: 711-719
- DOI
  10.1038/jhg.2013.90
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-23249049, KAKENHI-PUBLICLY-24110508, KAKENHI-PROJECT-24591198, KAKENHI-PUBLICLY-25110720, KAKENHI-PROJECT-25670420, KAKENHI-PROJECT-25713015
[Journal Article] A novel mutation in the C2 domain of protein kinase C gamma associated with spinocerebellar ataxia type 14.2013
- Author(s)
  Ueda T, Seki T, Katanazaka K, Sekiguchi K, Kobayashi K, Kanda F, Toda T.
- Journal Title
  
  J Neurol
  
  Volume: 260 Issue: 6 Pages: 1664-1666
- DOI
  10.1007/s00415-013-6916-0
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-23249049
[Journal Article] Novel POMGnT1 mutations cause muscle-eye-brain disease in Chinese patients2013
- Author(s)
  Jiao H, Manya H, Wang S, Zhang Y, Li X, Xiao J, Yang Y, Kobayashi K, Toda T, Endo T, Wu X, Xiong H.
- Journal Title
  
  Mol Genet Genomics
  
  Volume: 288 Issue: 7-8 Pages: 297-308
- DOI
  10.1007/s00438-013-0749-5
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-23249049, KAKENHI-PUBLICLY-24110523, KAKENHI-PROJECT-25293016
[Journal Article] 福山型筋ジストロフィーの新たな病態と分子標的治療2013
- Author(s)
  戸田達史, 池田真理子, 小林千浩
- Journal Title
  
  小児科診療
  
  Volume: 76 Pages: 671-671
- Data Source
  KAKENHI-PROJECT-23249049
[Journal Article] Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration. of its severe phenotype by limited gene expression.2013
- Author(s)
  Kanagawa M, et. al.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 22 Issue: 15 Pages: 3003-3015
- DOI
  10.1093/hmg/ddt157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02422, KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-24590497, KAKENHI-PROJECT-24659265, KAKENHI-PROJECT-24687017, KAKENHI-PROJECT-25702044
[Journal Article] 【検査値を読む2013】　遺伝子・染色体検査　先天性遺伝子検査福山型筋ジストロフィー遺伝子2013
- Author(s)
  小林千浩, 戸田達史
- Journal Title
  
  内科
  
  Volume: 111 Pages: 1087-1087
- Data Source
  KAKENHI-PROJECT-23249049
[Journal Article] A drug screening platform for Alzheimer's disease with intracellular Aβ oligomers using patient-specific iPSCs2013
- Author(s)
  Kondo, T., (他24名), Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., Inoue, H
- Journal Title
  
  Cell Stem Cell
  
  Volume: 12 Issue: 4 Pages: 487-496
- DOI
  10.1016/j.stem.2013.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PLANNED-22129006, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23592093, KAKENHI-PROJECT-24220009, KAKENHI-PROJECT-24500408, KAKENHI-PROJECT-24590040, KAKENHI-PROJECT-24700367, KAKENHI-PROJECT-24790260, KAKENHI-PROJECT-24790276, KAKENHI-PUBLICLY-25123709, KAKENHI-PROJECT-25290018, KAKENHI-PROJECT-25460341, KAKENHI-PUBLICLY-23110535, KAKENHI-PUBLICLY-23123510
[Journal Article] 【遺伝性筋疾患の新たな治療戦略】福山型筋ジストロフィーの新たな病態とアンチセンス療法2012
- Author(s)
  戸田達史, 谷口真理子(池田), 小林千浩
- Journal Title
  
  神経内科
  
  Volume: 76 Pages: 361-366
- Data Source
  KAKENHI-PROJECT-23249049
[Journal Article] Mislocalization of fukutin protein by disease-causing missense mutations can be rescued with treatments directed at folding amelioration2012
- Author(s)
  Tachikawa M, Kanagawa M, Yu CC, Kobayashi K, Toda T
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 8398-8406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689030
[Journal Article] Absence of post-phosphoryl modification in dystroglycanopathy mouse models and wild-type tissues expressing a non-laminin binding form ofα-dystroglycan2012
- Author(s)
  Kuga A, Kanagawa M, Sudo A, Chan YM, Tajiri M, Manya H, Kikkawa Y, Nomizu M, Kobayashi K, Endo T, Lu QL, Wada Y, Toda T
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 9560-9567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689030
[Journal Article] MEDICAL TOPICS(第42回)　福山型筋ジストロフィーのスプライシング異常に対するアンチセンス治療2012
- Author(s)
  谷口真理子(池田), 小林千浩, 戸田達史
- Journal Title
  
  THE LUNG-perspectives
  
  Volume: 20 Pages: 186-191
- Data Source
  KAKENHI-PROJECT-23249049
[Journal Article] 福山型筋ジストロフィーのスプライシング異常に対するアンチセンス治療2012
- Author(s)
  池田真理子,小林千浩,戸田達史
- Journal Title
  
  The LUNG perspective
  
  Volume: 20 Pages: 186-192
- Data Source
  KAKENHI-PROJECT-24591510
[Journal Article] [Molecular targeting therapy for Fukuyama muscular dystrophy2012
- Author(s)
  Toda T, Taniguchi-Ikeda M, Kobayashi K.
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 52 Pages: 1158-1158
- NAID
  130004505090
- Data Source
  KAKENHI-PROJECT-24591510
[Journal Article] Absence of post-phosphoryl modification in dystroglycanopathy mouse models and wild-type tissues expressing a non-laminin binding form of alpha-dystroglycan2012
- Author(s)
  Kuga A, Kanagawa M, Sudo A, Chan YM, Tajiri M, Manya H, Kikkawa Y, Nomizu M, Kobayashi K, Endo T, Lu QL, Wada Y, Toda T
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 9560-9567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249049
[Journal Article] 福山型筋ジストロフィーの病的スプライシング異常とアンチセンス療法2012
- Author(s)
  池田真理子,小林千浩,戸田達史
- Journal Title
  
  実験医学
  
  Volume: 30 Pages: 950-953
- Data Source
  KAKENHI-PROJECT-24591510
[Journal Article] 福山型筋ジストロフィーの病的スプライシング異常とアンチセンス療法2012
- Author(s)
  谷口(池田)真理子, 小林千浩, 戸田達史
- Journal Title
  
  実験医学
  
  Volume: 30 Pages: 950-953
- Data Source
  KAKENHI-PROJECT-23249049
[Journal Article] 【神経筋疾患の分子標的治療開発】福山型筋ジストロフィーの分子標的治療2012
- Author(s)
  戸田達史, 谷口真理子(池田), 小林千浩
- Journal Title
  
  BIO Clinica
  
  Volume: 27 Pages: 925-929
- Data Source
  KAKENHI-PROJECT-23249049
[Journal Article] Detection of the dystroglycanopathy protein, fukutin, using a new panel of site-specific monoclonal antibodies.2012
- Author(s)
  Lynch TA, Lam le T, Man Nt, Kobayashi K, Toda T, Morris GE.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 424 Issue: 2 Pages: 354-357
- DOI
  10.1016/j.bbrc.2012.06.147
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-23249049
[Journal Article] Pathogenic exon-trapping by SVA retrotransposon and rescue in Fukuyama muscular dystrophy2011
- Author(s)
  Taniguchi-Ikeda M, Kobayashi K, Kanagawa M, Yu CC, Mori K, Oda T, Kuga A, Kurahashi H, Akman HO, DiMauro S, Kaji R, Yokota T, Takeda S, Toda T
- Journal Title
  
  Nature
  
  Volume: 478 Issue: 7367 Pages: 127-131
- DOI
  10.1038/nature10456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390101, KAKENHI-PROJECT-21390269, KAKENHI-PROJECT-21689030, KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-22790980, KAKENHI-PUBLICLY-23013019, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23659182
[Journal Article] Pathogenic exon-trapping by SVA retrotransposon and rescue in Fukuyama muscular dystrophy2011
- Author(s)
  Taniguchi-Ikeda M, Kobayashi K(equally contributed), Kanagawa M, Yu CC, Mori K, Oda T, Kuga A, Kurahashi H, Akman HO, Dimauro S, Kaji R, Yokota T, Takeda S, Toda T
- Journal Title
  
  Nature
  
  Volume: 478 Pages: 127-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689030
[Journal Article] Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization2010
- Author(s)
  Kanagawa M, Omori Y, Sato S, Kobayashi K, Miyagoe-Suzuki Y, Takeda S, Endo T, Furukawa T, Toda T
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 31208-31216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689030
[Journal Article] Fukutin gene retrotransposal insertion in a non-Japanese Fukuyama congenital muscular dystrophy(FCMD) patient2009
- Author(s)
  Xiong H, Wang S, Kobayashi K, Jiang Y, Wang J, Chang X, Yuan Y, Liu J, Toda T, Fukuyama Y, Wu X
- Journal Title
  
  Am J Med Genet
  
  Volume: A149 Pages: 2403-2408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689030
[Patent] ジストログリカン糖鎖修飾異常に伴う疾患の治療剤及び関連酵素測定法2022
- Inventor(s)
  戸田達史，小林千浩，金川基，遠藤玉夫，萬谷博，和田芳直，田尻道子
- Industrial Property Rights Holder
  戸田達史，小林千浩，金川基，遠藤玉夫，萬谷博，和田芳直，田尻道子
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Acquisition Date
  2022
- Data Source
  KAKENHI-PROJECT-20H00526
[Patent] 腎毒性軽減剤2022
- Inventor(s)
  園家暁，藤原佳絵，戸田達史，池田真理子，小林千浩、他
- Industrial Property Rights Holder
  園家暁，藤原佳絵，戸田達史，池田真理子，小林千浩、他
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-20H00526
[Patent] 腎毒性軽減剤2022
- Inventor(s)
  園家暁，藤原佳絵，戸田達史，池田真理子，小林千浩、他
- Industrial Property Rights Holder
  園家暁，藤原佳絵，戸田達史，池田真理子，小林千浩、他
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20H00526
[Patent] 腎毒性軽減剤2022
- Inventor(s)
  園家暁，藤原佳絵，戸田達史，池田真理子，小林千浩、他
- Industrial Property Rights Holder
  園家暁，藤原佳絵，戸田達史，池田真理子，小林千浩、他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-113495
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20H00526
[Patent] 福山型筋ジストロフィー治療用医薬組成物2012
- Inventor(s)
  戸田達史, 小林千浩, 池田真理子
- Industrial Property Rights Holder
  国立大学法人神戸大学
- Industrial Property Rights Type
  特許
- Filing Date
  2012-04-05
- Data Source
  KAKENHI-PROJECT-23249049
[Patent] 福山型筋ジストロフィー治療用医薬組成物2012
- Inventor(s)
  戸田　達史、　小林　千浩、池田　真理子
- Industrial Property Rights Holder
  戸田　達史、　小林　千浩、池田　真理子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-086891
- Filing Date
  2012-04-05
- Data Source
  KAKENHI-PROJECT-23249049
[Patent] 福山型筋ジストロフィー治療用医薬組成物2012
- Inventor(s)
  戸田　達史、　小林　千浩、池田　真理子
- Industrial Property Rights Holder
  戸田　達史、　小林　千浩、池田　真理子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-086891
- Filing Date
  2012-04-05
- Data Source
  KAKENHI-PLANNED-22129006
[Presentation] 希少難病小児を対象とした第I相医師主導治験における患者リクルート2023
- Author(s)
  和田育江, 徳山友希乃, 平野麻理, 藤野悟央, 森豊隆志, 北村明日香, 高橋朗子, 小牧宏文, 小林千浩, 池田真理子, 石垣景子, 戸田達史
- Organizer
  第44回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24244
[Presentation] CDP-リビトールプロドラッグ治療はISPD欠損筋ジストロフィーマウスモデルを改善する2022
- Author(s)
  徳岡秀紀, 今江理恵子, 中島瞳, 萬谷博, 増田千明, 星野駿介, 小林千浩, Lefeber Dirk J., 松本理器, 岡田尚巳, 遠藤玉夫, 金川基, 戸田達史
- Organizer
  第8回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24244
[Presentation] 福山型先天性筋ジストロフィーに対するアンチセンス核酸治療薬NS-035の医師主導治験2022
- Author(s)
  藤野悟央, 北村明日香, 高橋朗子, 首藤篤史, 前田明子, 久保田暁, 小林千浩, 小牧宏文, 池田真理子, 石垣景子, 戸田達史
- Organizer
  第8回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24244
[Presentation] CDP-リビトールプロドラッグ治療はISPD欠損筋ジストロフィーマウスモデルを改善する2022
- Author(s)
  徳岡秀紀, 今江理恵子, 中島瞳, 萬谷博, 増田千明, 星野駿介, 小林千浩, Lefeber Dirk, 松本理器, 岡田尚巳, 遠藤玉夫, 金川基, 戸田達史
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H05648
[Presentation] CDP-リビトールプロドラッグ治療はISPD欠損筋ジストロフィーマウスモデルを改善する2022
- Author(s)
  徳岡秀紀, 今江理恵子, 中島瞳, 萬谷博, 増田千明, 星野駿介, 小林千浩, Lefeber Dirk, 松本理器, 岡田尚巳, 遠藤玉夫, 金川基, 戸田達史
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24244
[Presentation] ジストログリカノパチーモデルマウスの中枢神経病態の解析2022
- Author(s)
  首藤篤史, 金川基, 小林千浩, 戸田達史
- Organizer
  第8回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24244
[Presentation] Galectin 3 binding proteinは内在性のβ-セクレターゼ活性を制御することでAβ産生を抑制する2019
- Author(s)
  関恒慶, 金川基, 小林千浩, 古和久朋, 八幡直樹, 丸山敬, 岩田修永, 井上治久, 戸田達史
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16H05353
[Presentation] Wide distribution of alpha-synuclein oligomers in MSA brain detected by proximity ligation2019
- Author(s)
  関谷博顕, 古和久朋, 古閑日奈子, 髙田真利子, 佐竹渉, 二村直伸, 舟川格, 陣内研二, 高橋玄倫, 近藤武史, 上野易弘, 金川基, 小林千浩, 戸田達史
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16H05353
[Presentation] Galectin 3 binding proteinはBACE1活性しAβ産生を抑制する2019
- Author(s)
  関恒慶, 金川基, 小林千浩, 古和久朋, 八幡直樹, 丸山敬, 岩田修永, 井上治久, 戸田達史
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05353
[Presentation] LARGE Gene Therapy for α-Dystroglycanopathies2018
- Author(s)
  Yoshihisa Ohtsuka, Motoi Kanagawa, Tomoko Chiyo, Kazuhiro Kobayashi, Takashi Okada, Shin’ichi Takeda, Tatsushi Toda
- Organizer
  11th Japanese-French Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05353
[Presentation] ジストログリカノパチ－モデルマウスの中枢神経病態の解析2018
- Author(s)
  首藤篤史、金川基、近藤舞、伊藤千代美、小林千浩、遠藤光晴、南康博、饗場篤、戸田達史
- Organizer
  第37回日本糖質学会
- Data Source
  KAKENHI-PROJECT-16H05353
[Presentation] ジストログリカン異常症の原因となるリビトールリン酸タンデム構造とその生合成機構2017
- Author(s)
  小林　千浩、金川　基、田尻　道子、萬谷　博、久我　敦、山口　芳樹、和田　芳直、遠藤　玉夫、戸田　達史
- Organizer
  日本人類遺伝学会第６２回大会
- Data Source
  KAKENHI-PROJECT-16H05353
[Presentation] ジストログリカン異常症の原因となるリビトールリン酸タンデム構造とその生合成経路2017
- Author(s)
  小林　千浩
- Organizer
  ２０１７年度生命科学系学会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05353
[Presentation] αジストログリカン糖鎖のリビトールリン酸タンデム構造とその生合成経路2016
- Author(s)
  Kazuhiro Kobayashi, Motoi Kanagawa, Michiko Tajiri, Hiroshi Manya, Atsushi Kuga, Yoshiki Yamaguchi, Keiko Akasaka-Manya, Jun-ichi Furukawa, Mamoru Mizuno, Hiroko Kawakami, Yasuro Shinohara, Yoshinao Wada, Tamao Endo, Tatsushi Toda
- Organizer
  第２回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05353
[Presentation] αジストログリカン糖鎖のリビトールリン酸タンデム構造とその生合成機構2016
- Author(s)
  Kazuhiro Kobayashi, Motoi Kanagawa, Michiko Tajiri, Hiroshi Manya, Atsushi Kuga, Yoshiki Yamaguchi, Keiko Akasaka-Manya, Jun-ichi Furukawa, Mamoru Mizuno, Hiroko Kawakami, Yasuro Shinohara, Yoshinao Wada, Tamao Endo, Tatsushi Toda
- Organizer
  第３９回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H05353
[Presentation] A de novo mutation of the MYH7 gene in a large Chinese family with autosomal dominant myopathy2016
- Author(s)
  Kazuhiro Kobayashi, Tetsuya Oda, Hui Xiong, Wataru Satake, Tatsushi Toda
- Organizer
  The 13th International Congress of Human Genetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05353
[Presentation] Fukutin is prerequisite to ameliorate muscular dystrophy by LARGE expression2015
- Author(s)
  大塚　喜久、金川　基、游　智傑、伊藤　千代美、千代　智子、小林　千浩、岡田　尚巳、武田　伸一、戸田　達史
- Organizer
  第５６回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟県新潟市）
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26670499
[Presentation] 糖転移酵素LARGE活性を応用したジストログリカノパチー治療の検討2015
- Author(s)
  大塚　喜久、金川　基、千代　智子、小林　千浩、岡田　尚巳、武田　伸一、戸田　達史
- Organizer
  第３４回日本糖質学会年会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2015-07-31
- Data Source
  KAKENHI-PROJECT-26670499
[Presentation] 福山型先天性筋ジストロフィーのアンチセンス治療における至適薬剤の選択2015
- Author(s)
  池田真理子、佐藤洋平、若山達志、増田博文、小林千浩、森岡一朗、飯島一誠、戸田達史
- Organizer
  日本小児科学会
- Place of Presentation
  国際会議場　大阪
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-24591510
[Presentation] 福山型先天性筋ジストロフィーのアンチセンス治療における至適薬剤の選択2014
- Author(s)
  池田真理子、佐藤洋平、若山達志、増田博文、小林千浩、森岡一朗、飯島一誠、戸田達史
- Organizer
  日本人類遺伝学会
- Place of Presentation
  タワーホール舟橋　東京
- Year and Date
  2014-11-20
- Data Source
  KAKENHI-PROJECT-24591510
[Presentation] 福山型先天性筋ジストロフィーのアンチセンス治療における至適薬剤の選択2014
- Author(s)
  池田真理子、佐藤洋平、若山達志、増田博文、小林千浩、森岡一朗、飯島一誠、戸田達史
- Organizer
  小児神経学会
- Place of Presentation
  アクトシティー　浜松
- Year and Date
  2014-05-31
- Data Source
  KAKENHI-PROJECT-24591510
[Presentation] 福山型先天性筋ジストロフィーのアンチセンス治療における至適薬剤の選択2014
- Author(s)
  池田真理子、佐藤洋平、若山達志、増田博文、小林千浩、森岡一朗、飯島一誠、戸田達史
- Organizer
  日本小児遺伝学会
- Place of Presentation
  名古屋市立大学　愛知県
- Year and Date
  2014-04-10
- Data Source
  KAKENHI-PROJECT-24591510
[Presentation] RNA-based mechanism and therapy for muscular dystrophy.2012
- Author(s)
  戸田達史, 池田真理子, 小林千浩
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Invited
- Data Source
  KAKENHI-PROJECT-23249049
[Presentation] 福山型筋ジストロフィーのSVA挿入によるスプライシング異常とレスキュー2012
- Author(s)
  池田真理子，小林千浩，金川　基，遊　智傑，小田哲也，久我　敦，倉橋浩樹,　武田伸一，戸田達史
- Organizer
  日本小児科学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24591510
[Presentation] SVAレトロトランスポゾン挿入による病的exon-trappingと福山型筋ジストロフィーにおけるレスキュー2011
- Author(s)
  小林千浩
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-23249049
[Presentation] SVAレトロトランスポゾン挿入による病的exon-trappingと福山型筋ジストロフィーにおけるレスキュー2011
- Author(s)
  小林千浩
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-21689030
[Presentation] SVAレトロトランスポゾン挿入による病的exon-trappingと福山型筋ジストロフィーにおけるレスキュー2011
- Author(s)
  小林千浩
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  シフィコ横浜(神奈川)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-21689030
[Presentation] Genome-wide gene expression and DNA methylation analyses of significantly discordant monozygotic twins for cognitive ability2010
- Author(s)
  Kobayashi K
- Organizer
  American Society of Human Genetics 60th Annual Meeting
- Place of Presentation
  Washington Convention Center (Washington DC,米国)
- Year and Date
  2010-11-03
- Data Source
  KAKENHI-PLANNED-22129006
[Presentation] Genome-wide gene expression and DNA methylation analyses of significantly discordant monozygotic twins for cognitive ability.2010
- Author(s)
  Kobayashi K
- Organizer
  American Society of Human Genetics 60th Annual Meeting
- Place of Presentation
  Washington Convention Center(Washington DC,米国)
- Year and Date
  2010-11-03
- Data Source
  KAKENHI-PROJECT-21689030
[Presentation] 認知能力の差が顕著な一卵性双生児の分子遺伝学的解析2010
- Author(s)
  小林千浩
- Organizer
  日本人類遺伝学会第55回大会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PLANNED-22129006
[Presentation] 認知能力の差が顕著な一卵性双生児の網羅的遺伝子発現・DNAメチル化解析2010
- Author(s)
  小林千浩
- Organizer
  日本パーソナリティ心理学会第19回大会
- Place of Presentation
  慶應義塾大学三田キャンパス(東京都)(招待講演)
- Year and Date
  2010-10-11
- Data Source
  KAKENHI-PROJECT-21689030
[Presentation] 認知能力の差が顕著な一卵性双生児のDNAメチル化解析2010
- Author(s)
  小林千浩
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21689030
[Presentation] 認知能力の差が顕著な一卵性双生児の網羅的遺伝子発現・DNAメチル化解析2010
- Author(s)
  小林千浩
- Organizer
  日本パーソナリティ心理学会第19回大会
- Place of Presentation
  慶應義塾大学三田キャンパス(東京都)(招待講演)
- Year and Date
  2010-10-11
- Data Source
  KAKENHI-PLANNED-22129006
[Presentation] 認知能力の差が顕著な一卵性双生児の分子遺伝学的解析2010
- Author(s)
  小林千浩
- Organizer
  日本人類遺伝学会第55回大会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21689030
[Presentation] 認知能力の差が顕著な一卵性双生児のDNAメチル化解析2010
- Author(s)
  小林千浩
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PLANNED-22129006
[Presentation] Genes regulated by epigenetic mechanisms in determining general intelligence (g) are over-represented in disorders that affect cognition.
- Author(s)
  Pei-Chieng Cha, Kazuhiro Kobayashi, Yuko Ando, Keizo Takao, Tsuyoshi Miyakawa, Tatsushi Toda
- Organizer
  第59回日本人類遺伝学会
- Place of Presentation
  タワーホール船堀、東京
- Year and Date
  2014-11-19 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-24300104
[Presentation] Genes regulated by epigenetic mechanisms in determining general intelligence (g) are over-represented in disorders that affect cognition.
- Author(s)
  Pei-Chieng Cha, Kazuhiro Kobayashi, Yuko Ando, Keizo Takao, Tsuyoshi Miyakawa, Tatsushi Toda
- Organizer
  The 64th Annual Meeting of The American Society of Human Genetics
- Place of Presentation
  San Diego Convention Center, San Diego, USA
- Year and Date
  2014-10-18 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-24300104
[Presentation] Genes regulated by epigenetic mechanisms in determining general intelligence (g) are over-represented in disorders that affect cognition.
- Author(s)
  Pei-Chieng Cha, Kazuhiro Kobayashi, Yuko Ando, Keizo Takao, Tsuyoshi Miyakawa, Tatsushi Toda
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24300104
[]
[]
[]

1. TODA Tatsushi (30262025)

# of Collaborated Projects: 7 results

# of Collaborated Products: 22 results
2. IKEDA Mariko (00410738)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. KANAGAWA Motoi (00448044)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
4. Ando Juko (30193105)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Endo Tamao (30168827)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. 坂上雅道 (10225782)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 田村純一 (30221401)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SATAKE Wataru (50467594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. FUJISAWA Keiko (00453530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMAGATA Shinji (60625193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TOYODA Atsushi (10267495)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SOMEYA Yoshiaki (20392714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 石垣景子 (10366304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 加藤龍一 (50240833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 山口芳樹 (90323451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 永森收志 (90467572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 谷口敦彦 (30790125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TANIGUCHI Mariko

# of Collaborated Projects: 0 results

# of Collaborated Products: 15 results
19. IMAE Rieko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. MURAKAMI Kazuma

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 倉橋浩樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 島田和典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 丸山敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 野水基義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 早川英規

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 萬谷博

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
27. CHA PeiChieng

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. CHA Pei Chieng

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
29. 饗場篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 入江一浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 関恒慶

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Kazuhiro 小林 千浩

KOBAYASHI Kazuhiro 小林 千浩

小林 千浩 コバヤシ カズヒロ

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福山型筋ジストロフィーおよび類縁疾患の病態解析と治療法・薬効評価法の開発Principal Investigator

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Investigation of molecular pathogenesis and development of therapeutic methods for Fukuyama muscular dystrophy and related diseasesPrincipal Investigator

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Analysis of the causative glycan for muscular dystrophy and exploration of the therapeutic possibility of its neuronal dysfunctionPrincipal Investigator

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Identifying the genetic basis and understanding the molecular mechanisms underlying cognitive functionPrincipal Investigator

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Kobayashi Kazuhiro 小林千浩

KOBAYASHI Kazuhiro 小林千浩

小林千浩コバヤシカズヒロ