Yamazaki Tetsuo 山崎哲男

… Alternative Names

Researcher Number	90330208
Affiliation (Current)	2020: 徳島大学, 大学院医歯薬学研究部(薬学域), 教授
Affiliation (based on the past Project Information) *help	2018: 徳島大学, 大学院医歯薬学研究部(薬学域), 教授 2016 – 2017: 徳島大学, 大学院医歯薬学研究部(薬学系), 教授 2015: 徳島大学, 大学院医歯薬学研究部, 教授 2014: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 2012 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 教授 … More
Review Section/Research Field	Principal Investigator Experimental pathology / Immunology / Immunology / Biological Sciences / General medical chemistry / Pathological medical chemistry / Basic Section 49030:Experimental pathology-related Except Principal Investigator Biological Sciences / Biological pharmacy / Immunology
Keywords	Principal Investigator 小胞体 / BCR / BCAP / アダプター分子 / 転写因子 / シグナル伝達 / CLN6 / 凝集体 / クリスタリン / BLNK … More Except Principal Investigator シグナル伝達 / BCAP / アダプター分子 / PI3K / B細胞分化 / ノックアウトマウス / BCR / マクロファージ / p85サブユニット / Akt活性化 / JNK活性化 / DT40細胞 / Ｆ１Ｆｏ-ＡＴＰ合成酵素 / 脂肪細胞 / 細胞内中性脂肪 / 抗肥満薬 / ＡＴＰ / ＡＴＰ受容体 / ミトコンドリア / 国際情報交換 / エフェクター分子 / Bリンパ球分化 / 免疫応答 / PI3キナーゼ / B細胞活性化 / BANK / CD40 / B細胞活性 / アダプター分化 / 転写因子 / c-Rel / BLNK / PLC-γ2 / 抗原反応 / adaptor molecules / effector molecules / signal transduction / B lymphocyte development / immune response Less

ER manipulation-based therapeutic strategies against protein aggregation diseasesPrincipal InvestigatorOngoing
- Principal Investigator
  
  山崎哲男
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokushima
Development of ER-targeted therapeutics against protein aggregation diseasesPrincipal Investigator
- Principal Investigator
  
  YAMAZAKI Tetsuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokushima
Dvelopment of novel anti-obesity agents targeting cell-surface F1F0-ATP synthase
- Principal Investigator
  
  ARAKAKI Naokatu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokushima
MG23-mediatedcrosstalk between genetic system and immune system.Principal Investigator
- Principal Investigator
  
  YAMAZAKI Tetsuo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokushima
Analysis of the regulation of organelle-generated signals by the Novel endoplasmic protein caluminPrincipal Investigator
- Principal Investigator
  
  YAMAZAKI Tetsuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Analysis of regulation of carcinogenesis by the BCAP-binding molecule BB1Principal Investigator
- Principal Investigator
  
  YAMAZAKI Tetsuo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
アダプター分子BCAPによる発がん抑制機構の機序解明Principal Investigator
- Principal Investigator
  
  山崎哲男
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
アダプター分子BCAPの機能発現機序の解明Principal Investigator
- Principal Investigator
  
  山崎哲男
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
  Kansai Medical University
マクロファージ分化・活性化における新規アダプター分子BCAPの役割
- Principal Investigator
  
  石合正道
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kawasaki Medical School
モデルB細胞を用いた細胞増殖・細胞死制御におけるPI3K活性化の分子機構
- Principal Investigator
  
  石合正道
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kawasaki Medical School
B細胞アダプター分子BLNKに結合する新規蛋白質の機能解析Principal Investigator
- Principal Investigator
  
  山崎哲男
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kansai Medical University
Quantitative and qualitative regulation of cellular signaling in immune system
- Principal Investigator
  
  KUROSAKI Tomohiro
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  RIKEN
  Kansai Medical University

[Book] 医歯薬系学生のためのillustrated基礎生命科学2008
- Author(s)
  竹島浩、山崎哲男、池田篤史、輿水崇鏡
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-19590267
[Journal Article] Identification of CLN6 as a molecular entity of endoplasmic reticulum-driven anti-aggregate activity2017
- Author(s)
  Yamashita Arisa、Hiraki Yuri、Yamazaki Tetsuo
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 487 Pages: 917-922
- DOI
  10.1016/j.bbrc.2017.05.002
- NAID
  120006462780
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16J09784, KAKENHI-PROJECT-15K08404
[Journal Article] Prevention of aberrant protein aggregation by anchoring the molecular chaperone αB-crystallin to the endoplasmic reticulum2014
- Author(s)
  Yamamoto Shinichiro, Arisa Yamashita, Naokatu Arakaki, Nemoto Hisao, Tetsuo Yamazaki
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 455 Pages: 241-245
- DOI
  10.1016/j.bbrc.2014.10.151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590081
[Journal Article] Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death2013
- Author(s)
  Yamashita Arisa, Taniwaki Tatsuya, Kaikoi Yuka, Yamazaki Tetsuo
- Journal Title
  
  FEBS Letters
  
  Volume: Vol.587 Pages: 1299-1303
- DOI
  10.1016/j.febslet.2013.03.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590359
[Journal Article] Involvement of reactive oxygen species in osteoblastic differentiation of MC3T3-E1 cells accompanied by mitochondrial morphological dynamics2013
- Author(s)
  Naokatu Arakaki, Arisa Yamashita, Shingo Niimi, Tetsuo Yamazaki
- Journal Title
  
  Biomedical Research
  
  Volume: 34 Issue: 3 Pages: 161-166
- DOI
  10.2220/biomedres.34.161
- NAID
  130004470847
- ISSN
  0388-6107, 1880-313X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590081
[Journal Article] Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt.2012
- Author(s)
  Troutman, T.D., et al
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 109 Pages: 273-278
- DOI
  10.1073/pnas.1118579109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229007, KAKENHI-PROJECT-22590359
[Journal Article] A requirement for the p85 PI3K adapter protein BCAP in the protection of macrophages from apoptosis induced by endoplasmic reticulum stress2011
- Author(s)
  Song, SW., et al
- Journal Title
  
  J.Immunol.
  
  Volume: 187 Pages: 2819-2825
- DOI
  10.4049/jimmunol.0903425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229007, KAKENHI-PROJECT-22590359
[Journal Article] Facilitation of DNA damage-induced apoptosis by endoplasmic reticulum protein mitsugumin 232010
- Author(s)
  Yamazaki T, et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 392 Pages: 196-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590359
[Journal Article] Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes2009
- Author(s)
  Masumiya H., Asaumi Y., Nishi M., Minamisawa S., Adachi-Akahane S., Yoshida M., Kangawa K., Ito K., Kagaya Y., Yanagisawa T., Yamazaki T. , Ma J. and Takeshima H
- Journal Title
  
  Channels 3
  
  Pages: 6-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590267
[Journal Article] New molecular components supporting ryanodine receptor-mediated Ca2+ release : roles of junctophilin and TRIC channel in embryonic cardiomyocyes2009
- Author(s)
  Yamazaki D.
- Journal Title
  
  Pharmacol. Ther. 121
  
  Pages: 265-272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590267
[Journal Article] New molecular components supporting ryanodine receptor-mediated Ca^<2+> release : roles of junctophilin and TRIC channel in embryonic cardiomyocyes2009
- Author(s)
  Yamazaki D., Yamazaki T. and Takeshima H
- Journal Title
  
  Pharmacol. Therapeut 121
  
  Pages: 265-272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590267
[Journal Article] Regulation of B cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase2008
- Author(s)
  Aiba Y., Kameyama M., Yamazaki T., Tedder TF. And Kurosaki T
- Journal Title
  
  Blood 111
  
  Pages: 1497-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590267
[Journal Article] Enhanced NK-cell development and function in BCAP-deficient mice2008
- Author(s)
  MacFarlane IV AW., Yamazaki T., Fang M., Sigal LJ., Kurosaki T. and Campbell KS
- Journal Title
  
  Blood 112
  
  Pages: 131-140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590267
[Journal Article] Augmentation of drug-induced cell death by ER protein BRI3BP. Biochem. Biophys. Res2007
- Author(s)
  Yamazaki T. , Sasaki N., Nishi M., Yamazaki D., Ikeda A., Okuno Y., Komazaki S. and Takeshima H
- Journal Title
  
  Commun 362
  
  Pages: 971-975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590267
[Journal Article] Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins. Biochem. Biophys. Res2007
- Author(s)
  Ikeda A., Miyazaki T., Kakizawa S., Okuno Y., Tsuchiya S., Myomoto A., Saito S., Yamamoto T., Yamazaki T., Iino M., Tsujimoto G., Watanabe M. and Takeshima H
- Journal Title
  
  Commun 363
  
  Pages: 835-839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590267
[Journal Article] Calumin, a novel Ca2+ -binding protein on the endoplasmic reticulum2007
- Author(s)
  Zhang M., Yamazaki T. , Yazawa M., Treves S., Nishi M., Murai M., Shibata E., Zorzato F. and Takeshima H
- Journal Title
  
  Cell Calcium 42
  
  Pages: 83-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590267
[Journal Article] Augmentation of drug-induced cell death by ER protein BRI3BP2007
- Author(s)
  Yamazaki, T.
- Journal Title
  
  Biochem Biophys Res Commun. 362
  
  Pages: 971-975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590267
[Journal Article] Contribution of BCAP to maintenance of mature B cells through c-Rel.2003
- Author(s)
  Yamazaki, T., Kurosaki, T.
- Journal Title
  
  Nat.Immunol. 4
  
  Pages: 780-786
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854013
[Journal Article] Essential immunoregulatory role for BCAP in B cell development and function.2002
- Author(s)
  Yamazaki, T. et al.
- Journal Title
  
  J.Exp.Med. 195
  
  Pages: 535-545
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854013
[Journal Article] BANK negatively regulates Akt activation and subsequent B cell responses.
- Author(s)
  Aiba, Y., Yamazaki, T., Okada, T., Gotoh, K, Sanjo, H., Ogata, M., Kurosaki, T.
- Journal Title
  
  Immunity (印刷中)
- Data Source
  KAKENHI-PROJECT-13854013
[Presentation] ER-driven anti-aggregate activity toward pathogenic alphaB-crystallin mutants2018
- Author(s)
  Arisa Yamashita and Tetsuo Yamazaki
- Organizer
  The 43rd FEBS Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07045
[Presentation] 小胞体マニピュレーションがもたらす抗凝集体活性の分子基盤2017
- Author(s)
  山下ありさ, 山崎哲男
- Organizer
  第16回四国免疫フォーラム
- Data Source
  KAKENHI-PROJECT-15K08404
[Presentation] タンパク質凝集体難病の克服に向けた小胞体操作法の開発2017
- Author(s)
  平木友理, 山崎哲男
- Organizer
  第90回蔵本免疫懇話会
- Data Source
  KAKENHI-PROJECT-15K08404
[Presentation] ER manipulation: A promising therapeutic intervention for protein aggregation diseases2017
- Author(s)
  Yamashita A., Nakatsuru T., Saito H., Hiraki Y. and Yamazaki T.
- Organizer
  The 3rd International Symposium on Regenerative Rehabilitation in Kyoto
- Place of Presentation
  京都大学　杉浦地域医療研究センター（京都府京都市）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08404
[Presentation] タンパク質凝集体難病の克服に向けた小胞体操作法の開発2017
- Author(s)
  山崎哲男
- Organizer
  稀少疾患プロジェクト　オープンセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-15K08404
[Presentation] タンパク質凝集体難病の克服に向けた小胞体操作の分子基盤2016
- Author(s)
  山下ありさ, 山崎哲男
- Organizer
  四国免疫フォーラム
- Place of Presentation
  高知大学医学部（高知県南国市）
- Data Source
  KAKENHI-PROJECT-15K08404
[Presentation] ER as a potential therapeutic target for protein aggregation disease2016
- Author(s)
  山崎哲男
- Organizer
  The Fifth Bizan Immunology Symposium at University of Tokushima
- Place of Presentation
  徳島大学藤井記念ホール(徳島県徳島市)
- Year and Date
  2016-03-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08404
[Presentation] 小胞体を標的とした凝集体難病治療法開発2015
- Author(s)
  山下ありさ, 山崎哲男
- Organizer
  第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  高知市文化プラザかるぽーと(高知県高知市)
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-15K08404
[Presentation] 小胞体マニピュレーションに基づく凝集体難病治療法の創出2015
- Author(s)
  山下ありさ, 山崎哲男
- Organizer
  第14回四国免疫フォーラム
- Place of Presentation
  愛媛大学医学部40周年記念講堂(愛媛県東温市)
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-15K08404
[Presentation] ミトコンドリア由来のROSシグナルは骨芽細胞の分化を誘導する2012
- Author(s)
  山崎哲男
- Organizer
  第51回日本薬学会・日本薬剤師会・日本病院薬剤師会・中国四国支部学術大会
- Place of Presentation
  島根県民会館・サンラポーむらくも(松江市)
- Data Source
  KAKENHI-PROJECT-22590359
[Presentation] ミトコンドリア由来のROSシグナルは骨芽細胞の分化を誘導する2012
- Author(s)
  駒田致和、新垣尚捷、山崎哲男
- Organizer
  第５１回　日本薬学会・日本薬剤師会・日本病院薬剤師会　中国四国支部学大会
- Place of Presentation
  島根県民会館・サンラポーむらくも（島根県）
- Data Source
  KAKENHI-PROJECT-24590081
[Presentation] 小胞体タンパク質EPIGは紫外線照射による細胞死を抑制する2012
- Author(s)
  山崎哲男
- Organizer
  第51回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  島根県民会館・サンラポーむらくも（島根県）
- Data Source
  KAKENHI-PROJECT-22590359
[Presentation] ミトコンドリア由来のROSシグナルは骨芽細胞の分化を誘導する2012
- Author(s)
  山崎哲男
- Organizer
  第51回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  島根県民会館・サンラポーむらくも（島根県）
- Data Source
  KAKENHI-PROJECT-22590359
[Presentation] 小胞体タンパク質EPIGは紫外線照射による細胞死を抑制する2012
- Author(s)
  山崎哲男
- Organizer
  第51回日本薬学会・日本薬剤師会・日本病院薬剤師会・中国四国支部学術大会
- Place of Presentation
  島根県民会館・サンラポーむらくも(松江市)
- Data Source
  KAKENHI-PROJECT-22590359
[Presentation] 小胞体タンパク質EPIGの紫外線応答における役割2011
- Author(s)
  山崎哲男
- Organizer
  第50回日本薬学会・日本薬剤師会・日本病院薬剤師会・中国四国支部学術大会
- Place of Presentation
  サンポートホール高松・かがわ国際会議場(高松市)
- Data Source
  KAKENHI-PROJECT-22590359
[Presentation] 小胞体タンパク質EPIGの紫外線応答における役割2011
- Author(s)
  山崎哲男
- Organizer
  第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  サンポートホール高松(香川県)
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-22590359
[Presentation] 小胞体のシグナル特性から免疫へ2010
- Author(s)
  山崎哲男
- Organizer
  免疫シグナルシンポジウム
- Place of Presentation
  東京コンファレンスセンター・品川(東京都)
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-22590359
[Presentation] 小胞体タンパク質mitsugumin23によるDNA損傷性細胞死の促進2010
- Author(s)
  山崎哲男
- Organizer
  第117回日本薬理学会近畿部会
- Place of Presentation
  徳島県郷土文化会館(徳島市)
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-22590359
[Presentation] 小胞体蛋白質MG23を介した小胞体発シグナルと細胞死2007
- Author(s)
  山崎哲男
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19590267

1. 石合正道 (90298844)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. ARAKAKI Naokatu (60151148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. NEMOTO Hisao (30208293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. KUROSAKI Tomohiro (50178125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. HIKIDA Masaki (60228715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 大洞将嗣 (40351506)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 井鍋一則 (30309215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yamazaki Tetsuo 山崎 哲男

YAMAZAKI Tetsuo 山崎 哲男

Research Projects

Research Products

Co-Researchers

ER manipulation-based therapeutic strategies against protein aggregation diseasesPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of ER-targeted therapeutics against protein aggregation diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dvelopment of novel anti-obesity agents targeting cell-surface F1F0-ATP synthase

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MG23-mediatedcrosstalk between genetic system and immune system.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the regulation of organelle-generated signals by the Novel endoplasmic protein caluminPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of regulation of carcinogenesis by the BCAP-binding molecule BB1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アダプター分子BCAPによる発がん抑制機構の機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アダプター分子BCAPの機能発現機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マクロファージ分化・活性化における新規アダプター分子BCAPの役割

Principal Investigator

Project Period (FY)

Research Category

Review Section

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モデルB細胞を用いた細胞増殖・細胞死制御におけるPI3K活性化の分子機構

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B細胞アダプター分子BLNKに結合する新規蛋白質の機能解析Principal Investigator

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Quantitative and qualitative regulation of cellular signaling in immune system

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[Book] 医歯薬系学生のためのillustrated基礎生命科学2008

Author(s)

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Yamazaki Tetsuo 山崎哲男

YAMAZAKI Tetsuo 山崎哲男