FUJIE Hajime 藤江肇

Researcher Number	90332577
Affiliation (based on the past Project Information) *help	2007 – 2010: 東京大学, 医学部附属病院, 助教 2007 – 2008: University of Tokyo, Faculty of Medicine, Associate 2002 – 2006: THE UNIVERSITY OF TOKYO, FACULTY OF MEDICINE, RESEARCH ASSOClATE, 医学部附属病院, 助手 2001: The Univ. of Tokyo, Dpt. of. Medicine, assistant professor, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology / Metabolomics
Keywords	Principal Investigator C型肝炎ウイルスコア蛋白 / C型肝炎ウイスルコア蛋白 / インスリン抵抗性 / ミトコンドリア / C型肝炎 / ミトコンドリア電子伝達系 Except Principal Investigator ROS / トランスジェニックマウス / C型肝炎ウイルス / C型肝炎 … More / HCV / transgenic mouse / ミトコンドリア / インスリン抵抗性 / nuclear receptor / steatosis / core protein / コア蛋白 / alcohol / アルコール / 脂質代謝 / レプリコン / 肝線維化 / proteasome activator / metabolism / insulin resistance / プロテアゾームアクチベーター / プロテアゾームアクテベーター / 核内受容体 / プロテアゾームアクティベーター / 代謝 / 肝脂肪化 / Lipid metabolism / Insulin resistance / 核内レセプター / hepatocarcinogenesis / electron transfer system / proteomics / mitochondrion / hepatitis C virus / 肝発がん / 電子伝達系 / プロテオミクス / cytotoxic lymphocytes / inflammation / transgenic mice / hepatocarcinogeneis / 細胞障害性リンパ球 / 脂肪化 / 炎症 / 肝癌 / hydroperoxide / Hepatitis C virus / 脂質 / 過酸化脂質 / spheroid HepG2細胞 / APoE rich Lipoprotein / ステロリン / 胆汁 / 肝臓 / NPC1L1 / ABCG8 / ABCG5 / 肝細胞癌 / 脂肪酸 / 酸化ストレス / 脂質代謝異常 / 癌 / ウイルス肝炎 / プロテアーゼ / siRNA / ウイルス増殖 / 肝再生 / HIV・HCV重複感染症 / HIV感染症 Less

Metabolic abnormalities in hepatitis C and its impact on the progression of liver disease
- Principal Investigator
  
  KOIKE Kazuhiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Analyses on the mechanisms for cholesterol excretion from liver.
- Principal Investigator
  
  TSUKAMOTO Kazuhisa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
C型肝炎ウイルスRNAのマイクロ断片化によるウイルス増殖制御法の開発
- Principal Investigator
  
  小池和彦
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Hepatitis C as a Metabolic Disease : Pathogenesis for liver cancer and lifestyle-related diseases
- Principal Investigator
  
  KOIKE Kazuhiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
HIV感染によるC型慢性肝炎進行促進機序の解明
- Principal Investigator
  
  KOIKE Kazuhiko
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
C型慢性肝炎における糖代謝異常-インスリン抵抗性と肝発癌-Principal Investigator
- Principal Investigator
  
  藤江肇
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Functional abnormality in the mitochondria and pathogenesis of chronic hepatitis C: relation to hepatocellular carcinoma
- Principal Investigator
  
  KOIKE Kazuhiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Regulation of hepatocarcinogenesis by using antagonists to retinoid X receptor alpha RXRalpha.
- Principal Investigator
  
  MORIYA Kyoji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
C型肝炎におけるミトコンドリア電子伝達系障害とその肝発癌への関与Principal Investigator
- Principal Investigator
  
  藤江肇
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
THE ROLES OF HEPATITIS C VIRUS AND INFLAMMATION IN THE PATHOGENESIS OF HEPATOCELLULAR CARCINOMA
- Principal Investigator
  
  KOIKE Kazuhiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  THE UNIVERSITY OF TOKYO
Studies on synergistic effects of the HBV and HCV in hepatocarcinogenesis by using transgenic mice model
- Principal Investigator
  
  MORITA Kyoji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo

All 2011 2010 2009 2008 2004 2003

All Journal Article

[Journal Article] Intrahepatic bile duct dilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma: impact on patient's prognosis.2011
- Author(s)
  Kondo Y, Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Goto E, Nakagawa H, Masuzaki R, Asaoka Y, Fujie H, Goto T, Omata M, Yoshida H, Koike K.
- Journal Title
  
  Liver Int 31
  
  Pages: 197-205
- Data Source
  KAKENHI-PROJECT-20390204
[Journal Article] Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein.2011
- Author(s)
  Miyoshi H, Moriya K, Tsutsumi T Shinzawa S, Fujie H, Shintani Y, Fujinaga H, Goto K, Todoroki T, Suzuki T, Miyamura T, Matsuura Y, Yotsuyanagi H, Koike K.
- Journal Title
  
  J Hepatol 54
  
  Pages: 432-438
- Data Source
  KAKENHI-PROJECT-20390204
[Journal Article] Intrahepatic bile duct dilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma : impact on patient's prognosis2011
- Author(s)
  Kondo Y, Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Goto E, Nakagawa H, Masuzaki R, Asaoka Y, Fujie H, Goto T, Omata M, Yoshida H, Koike K.
- Journal Title
  
  Liver Int
  
  Volume: 31 Pages: 197-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390204
[Journal Article] Pathogenesis of lipid metabolism disorder in hepatitis C : polyunsaturated fatty acids counteract lipid alterations induced by the core protein.2011
- Author(s)
  Miyoshi H, Moriya K, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, Fujinaga H, Goto K, Todoroki T, Suzuki T, Miyamura T, Matsuura Y, Yotsuyanagi H, Koike K.
- Journal Title
  
  J Hepatol
  
  Volume: 54 Pages: 432-438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390204
[Journal Article] Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells.2010
- Author(s)
  Moriya K, Miyoshi H, Shinzawa S, Tsutsumi T, Fujie H, Goto K, Shintani Y, Yotsuyanagi H, Koike K.
- Journal Title
  
  J Med Virol 82
  
  Pages: 776-792
- Data Source
  KAKENHI-PROJECT-20390204
[Journal Article] Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells2010
- Author(s)
  Moriya K, Miyoshi H, Shinzawa S, Tsutsumi T, Fujie H, Goto K, Shintani Y, Yotsuyanagi H, Koike K.
- Journal Title
  
  J Med Virol
  
  Volume: 82 Pages: 776-792
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390204
[Journal Article] Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperone, prohibitin, in cells expressing hepatitis C virus core protein.2009
- Author(s)
  Tsutsumi T, Matsuda M, Aizaki H, Moriya K, Miyoshi H, Fujie H, Shintani Y, Yotsuyanagi H, Miyamura T, Suzuki T, Koike K.
- Journal Title
  
  Hepatology 50
  
  Pages: 378-386
- Data Source
  KAKENHI-PROJECT-20390204
[Journal Article] Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis C virus core protein: Analysis using mouse model and cultured cells.2009
- Author(s)
  Moriya K, Miyoshi H, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, Yotsuyanagi H, Moriishi K, Matsuura Y, Suzuki T, Miyamura T, Koike K.
- Journal Title
  
  Am J Pathol 175
  
  Pages: 1515-1524
- Data Source
  KAKENHI-PROJECT-20390204
[Journal Article] Molecular basis for the synergy between alcohol and hepatitis C virus in hepatocarcinogenesis.2008
- Author(s)
  Koike K, Tsutsumi T, Miyoshi H, Shinzawa S, Shintani Y, Fujie H, Yotsuyanagi H, Moriya K.
- Journal Title
  
  J Gastroenterol Hepatol 23
- Data Source
  KAKENHI-PROJECT-20390204
[Journal Article] Prevalence of hepatitis B virus infection in patients with human immunodeficiency virus in Japan.2008
- Author(s)
  Koike K, Kikuchi Y, Kato M, Takamatsu J, Shintani Y, Tsutsumi T, Fujie H, Miyoshi H, Moriya K, Yotsuyanagi H.
- Journal Title
  
  Hepatol Res 38
  
  Pages: 310-314
- Data Source
  KAKENHI-PROJECT-20390204
[Journal Article] Hepatitis C virus infection and diabetes : direct involvement of the virus in the develonment of insulin resistance2004
- Author(s)
  Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, Moriya K, Koike K.
- Journal Title
  
  Gastroenterology 126(3)
  
  Pages: 840-848
- Data Source
  KAKENHI-PROJECT-15590624
[Journal Article] Methylation status of suppressor of cytokine sigasling-1 gene in hepatocellular carcinoma2004
- Author(s)
  Miyoshi H, Fujie H, Moriya K, Shintani Y, Tsutsumi T, Makuuchi M, Kimura S, Koike K.
- Journal Title
  
  J Gastroenterol 39(6)
  
  Pages: 563-569
- Data Source
  KAKENHI-PROJECT-15590624
[Journal Article] Methylation status of suppressor of cytokine signaling-1 gene in hepatocellular carcinoma.2004
- Author(s)
  Miyoshi H, Fujie H, Moriya K, Shintani Y, Tsutsumi T, Makuuchi M, Kimura S, Koike K.
- Journal Title
  
  Journal of Gastroenterology 39(6)
  
  Pages: 563-569
- NAID
  10013296326
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590624
[Journal Article] Methylation status of suppressor of cytokine signaling-1 gene in hepatocellular carcinoma.2004
- Author(s)
  Miyoshi H, Fujie H, Mariya K, Shintani Y, Tsutsumi T, Makuuchi M, Kimura S, Koike K.
- Journal Title
  
  J Gastroenterol 39
  
  Pages: 563-569
- NAID
  10013296326
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390226
[Journal Article] Hepatitis C and Diabetes Mellitus : what is the metabolic pathway?2004
- Author(s)
  Koike K, Fujie H, Shintani Y, Miyoshi H, Mariya K.
- Journal Title
  
  Gastroenterology 127
  
  Pages: 1280-1281
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390226
[Journal Article] Hepatitis C virus infection and diabetes : direct involvement of the virus in the development of insulin resistance.2004
- Author(s)
  Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, Moriya K, Koike K.
- Journal Title
  
  Gastroenterology 126(3)
  
  Pages: 840-848
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590624
[Journal Article] Hepatitis C virus and diabetes : direct involvement of the virus in the development of insulin resistance.2004
- Author(s)
  Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Kimura S, Mariya K, Koike K.
- Journal Title
  
  Gastroenterology 126
  
  Pages: 840-848
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390226
[Journal Article] Methylation status of suppressor of cytokine signaling-1 gene in hepatocellular carcinoma.2004
- Author(s)
  Miyoshi H, Fujie H, Moriya K, Shintani Y, Tsutsumi T, Makuuchi M, Kimura S, Koike K.
- Journal Title
  
  J Gastroenterol. 39(6)
  
  Pages: 563-569
- NAID
  10013296326
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590624
[Journal Article] Hepatitis C virus infection and diabetes : direct involvement of the virus in the development of insulin resistance.2004
- Author(s)
  Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, Moriya K, Koike K.
- Journal Title
  
  Gastraenterolagy. 126(3)
  
  Pages: 840-848
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590624
[Journal Article] Serum lipid profile of patients with genotype 1b hepatitis C viral infection in Japan.2003
- Author(s)
  Moriya K, Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Yotsuyanagi H, Iino S, Kimura S, Koike K.
- Journal Title
  
  Hepatol Res. 25(4)
  
  Pages: 371-376
- NAID
  50000829733
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590624
[Journal Article] Hepatitis C virus core protein activates ERK and p38 MAPK in cooperation with ethanol in transgenic mice.2003
- Author(s)
  Tsutsumi T, Suzuki T, Moriya K, Shintani Y, Fujie H, Miyoshi H, Matsuura Y, Koike K, Miyamura T.
- Journal Title
  
  Hepatology 38(4)
  
  Pages: 820-828
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590624
[Journal Article] Serum lipid profile of patients with genotype 1b hepatitis C viral infection in Japan2003
- Author(s)
  Moriya K, Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Yotsuyanagi H, Iino S, Kimura S, Koike K.
- Journal Title
  
  Hepatology Research 25(4)
  
  Pages: 371-376
- NAID
  50000829733
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590624
[Journal Article] Hepatitis C virus core protein activates ERK and p38 MAPK in cooperation with ethanol in transgenic mice.2003
- Author(s)
  Tsutsumi T, Suzuki T, Moriya K, Shintani Y, Fujie H, Miyoshi H, Matsuura Y, Koike K, Miyamura T.
- Journal Title
  
  Hepatology. 88(4)
  
  Pages: 820-828
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590624

1. KOIKE Kazuhiko (80240703)

# of Collaborated Projects: 8 results

# of Collaborated Products: 23 results
2. MORIYA Kyouji (00272550)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
3. YOTSUYANAGI Hiroshi (30251234)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
4. SHINTANI Yoshizumi (80261965)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
5. TSUKAMOTO Kazuhisa (20251233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ISOーO Naoyuki (80420214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MIYOSHI Hideyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
8. TSUTSUMI Takeya

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results

FUJIE Hajime 藤江 肇

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C型慢性肝炎における糖代謝異常-インスリン抵抗性と肝発癌-Principal Investigator

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C型肝炎におけるミトコンドリア電子伝達系障害とその肝発癌への関与Principal Investigator

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[Journal Article] Intrahepatic bile duct dilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma: impact on patient's prognosis.2011

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Data Source

[Journal Article] Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein.2011

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[Journal Article] Intrahepatic bile duct dilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma : impact on patient's prognosis2011

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[Journal Article] Pathogenesis of lipid metabolism disorder in hepatitis C : polyunsaturated fatty acids counteract lipid alterations induced by the core protein.2011

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[Journal Article] Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells.2010

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FUJIE Hajime 藤江肇