HIRATA Takahiro 平田隆弘

Researcher Number	90333450
Other IDs
Affiliation (based on the past Project Information) *help	2007 – 2008: Josai International University, 薬学部, 教授 2001 – 2006: 大阪大学, 産業科学研究所, 助手
Review Section/Research Field	Principal Investigator Biological pharmacy Except Principal Investigator Bacteriology (including Mycology) / Biological Sciences
Keywords	Principal Investigator 異物排出蛋白 / GFP / 感染症 / 異物排出蛋白質 / 細菌 Except Principal Investigator multidrug resistance / トランスポーター / 多剤排出タンパク / 異物排出タンパク / 多剤排出 … More / AcrB / 多剤耐性 / 異物排出トランスポーター / X-ray crystallography / pathogenicity / indole / expression regulation system / two-component signal transduction / transporter / xenobiotic exporter / 発現ライブラリ / 排出タンパク / 遺伝子ライブラリ / 強制発現 / ポストゲノム / 核様体タンパク / TolC / β-ラクタム耐性 / マイクロアレイ / クオラムセンシング / 二成分情報伝達 / 発現制御 / 結晶構造解析 / 病原性 / インドール / 二成分情報伝達系 / 発現調節 / xenobiotic recognition / active transporter / membrane transport / multidrug efflux / X-ray crystal structure / Xenobiotic exporter / 分子構造 / RND / 膜タンパク質 / NEM / Cys走査変異 / 部位特異変異導入 / アンチポーター / フェニルアラニンクラスター / 部位特異的変異導入 / 基質結合型結晶 / フェニルアラニンクラスタ / 結晶構造 / 異物認識 / 能動輸送 / 膜輸送 / X線結晶構造 Less

Physiological functions of bacterial efflux transportersPrincipal Investigator
- Principal Investigator
  
  HIRATA Takahiro
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Josai International University
  Osaka University
Studies on the crystal structure of antiporters for organic compounds and the mechanisms
- Principal Investigator
  
  YAMAGUCHI Akihito
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Post-Genomic Approach to Bacterial Xenobiotic Exporter Gene Resources and Investigation of Novel Drug Resistance Mechanisms of Bacteria
- Principal Investigator
  
  YAMAGUCHI Akihito
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Osaka University

All 2009 2008 2007 2006 2005 2004 2003 2002

All Journal Article Presentation Book

[Book] CBT対策と演習生化学2009
- Author(s)
  平田隆弘, 他(分担執筆)
- Total Pages
  281
- Publisher
  廣川書店
- Data Source
  KAKENHI-PROJECT-18590055
[Book] 薬学領域における病原微生物学・感染症学・化学療法学2007
- Author(s)
  平田隆弘, 他
- Total Pages
  575
- Publisher
  廣川書店
- Data Source
  KAKENHI-PROJECT-18590055
[Book] 薬学領域における病原微生物学・感染症学・化学療法学2007
- Author(s)
  平田隆弘他(分担執筆)
- Total Pages
  575
- Publisher
  廣川書店
- Data Source
  KAKENHI-PROJECT-18590055
[Journal Article] AcrS/EnvR represses expression of the acrAB multidrug efflux genes in Escherichia coli2008
- Author(s)
  Hirakawa H, Takumi-Kobayashi A, Theisen U, Hirata T, Nishino K, Yamaguchi A
- Journal Title
  
  Journal of Bacteriology 190
  
  Pages: 6276-6279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590055
[Journal Article] Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner2006
- Author(s)
  Nobuyoshi Kobayashi, Tsuyoshi Nishi, Takahiro Hirata, Akio Kihara, Takamitsu Sano, Yasuyuki Igarashi, Akihito Yamaguchi
- Journal Title
  
  Journal of Lipid Research 47
  
  Pages: 614-621
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854012
[Journal Article] Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner2006
- Author(s)
  Nobuyoshi Kobayashi, Tsuyoshi Nishi, Takahiro Hirata, Akio Kihara, Takamitsu Sano, Yasuyuki Igarashi, Akihito Yamaguchi
- Journal Title
  
  Journal of Lipid Research 47
  
  Pages: 614-621
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142205
[Journal Article] N-acetyl-D-glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite activation in Escherichia coli2006
- Author(s)
  Hirakawa H, Inazumi Y, Senda Y, obayashi A, Hirata T, Nishino K, Yamaguchi A
- Journal Title
  
  Journal of Bacteriology 188
  
  Pages: 5851-5858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590055
[Journal Article] Growth phase-dependent expression of drug exporters in Escherichia coli and its contribution to drug tolerance2006
- Author(s)
  Kobayashi A, Hirakawa H, Hirata T, Nishino K, Yamaguchi A
- Journal Title
  
  Journal of Bacteriology 188
  
  Pages: 5693-5703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590055
[Journal Article] N-acetyl-d-glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite activation in Escherichia coli2006
- Author(s)
  Hirakawa H, Inazumi Y, Senda Y, Kobayashi A, Hirata T, Nishino K, Yamaguchi A
- Journal Title
  
  Journal of Bacteriology 188
  
  Pages: 5851-5858
- Data Source
  KAKENHI-PROJECT-18590055
[Journal Article] Indole induces the expression of multidrug exporter genes in Escherichia coli2005
- Author(s)
  Hidetada Hirakawa, Yoshihiko Inazumi, Takeshi Masaki, Takahiro Hirata, Akihito Yamaguchi
- Journal Title
  
  Molecular Microbiology 55
  
  Pages: 1113-1126
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854012
[Journal Article] Indole induces the expression of multidrug exporter genes in Escherichia coli2005
- Author(s)
  Hidetada Hirakawa, Yoshihiko Inazumi, Takeshi Masaki, Takahiro Hirata, Akihito Yamaguchi
- Journal Title
  
  Molecular Microbiology 55
  
  Pages: 1113-1126
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142205
[Journal Article] Indole induces the expression of multidrug exporter genes in Escherichia coil.2005
- Author(s)
  Hirakawa, H., Y.Inazumi, T.Masaki, T.Hirata, A.Yamaguchi
- Journal Title
  
  Molecular Microbiology 55
  
  Pages: 1113-1126
- Data Source
  KAKENHI-PROJECT-13142205
[Journal Article] Indole induces the expression of multidrug exporter genes in Esche richia coli.2005
- Author(s)
  Hirakawa, H., Y.Inazumi, T.Masaki, T.Hirata, A.Yamaguchi.
- Journal Title
  
  Molecular Microbiology 55
  
  Pages: 1113-1126
- Data Source
  KAKENHI-PROJECT-13854012
[Journal Article] Extramembrane central pore of multidrug exporter AcrB in Escherichia coil plays an important role in drug transport.2004
- Author(s)
  Murakami, S., N.Tamura, A.Saito, T.Hirata, A.Yamaguchi.
- Journal Title
  
  Journal of Biological Chemistry 279
  
  Pages: 3743-3748
- Data Source
  KAKENHI-PROJECT-13854012
[Journal Article] Extramembrane central pore of multidrug exporter AcrB in Escherichia coil plays an important role in drug transport.2004
- Author(s)
  Murakami, S., N.Tamura, A.Saito, T.Hirata, A.Yamaguchi.
- Journal Title
  
  Journal of Biological Chemistry 279
  
  Pages: 3743-3748
- Data Source
  KAKENHI-PROJECT-13142205
[Journal Article] Effects of efflux transporter genes on susceptibility of Escherichia coil to tigecycline (GAR-936).2004
- Author(s)
  Hirata, T., A.Saito, K.Nishino, N.Tamura, A.Yamaguchi.
- Journal Title
  
  Antimicrobial Agents Chemotherapy 48
  
  Pages: 2179-2184
- Data Source
  KAKENHI-PROJECT-13142205
[Journal Article] Effects of efflux transporter genes on susceptibility of Escherichia coli to Tigecycline (GAR-936)2004
- Author(s)
  Takahiro Hirata
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 48
  
  Pages: 2179-2184
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854012
[Journal Article] Effects of efflux transporter genes on susceptibility of Escherichia coli to Tigecycline (GAR-936)2004
- Author(s)
  Takahiro Hirata, Asami Saito, Kunihiko Nishino, Norihisa Tamur, Akihito Yamaguchi
- Journal Title
  
  Antimicrob. Agents Chemother. 48
  
  Pages: 2179-2184
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142205
[Journal Article] Effects of efflux transporter genes on susceptibility of Escherichia coli to Tigecycline (GAR-936)2004
- Author(s)
  Takahiro Hirata, Asami Saito, Kunihiko Nishino, Norihisa Tamura, Akihito Yamaguchi
- Journal Title
  
  Antimicrob.Agents Chemother. 48
  
  Pages: 2179-2184
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854012
[Journal Article] Extramembrane central pore of multidrug exporter AcrB in Escherichia coli plays an important role in drug transport2004
- Author(s)
  Satoshi Murakami, Norihisa Tamura, Asami Saito, Takahiro Hirata, Akihito Yamaguchi
- Journal Title
  
  The Journal of Biological Chemistry 279
  
  Pages: 3743-3748
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142205
[Journal Article] Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline(GAR-936).2004
- Author(s)
  Hirata, T., A.Saito, K.Nishino, N.Tamura, A.Yamaguchi.
- Journal Title
  
  Antimicrobial Agents Chemotherapy 48
  
  Pages: 2179-2184
- Data Source
  KAKENHI-PROJECT-13854012
[Journal Article] Effects of efflux transporter genes on susceptibility of Escherichia coli to Tigecycline (GAR-936)2004
- Author(s)
  Takahiro Hirata
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 48
  
  Pages: 2179-2184
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13142205
[Journal Article] Extramembrane central pore of multidrug exporter AcrB in Escherichia coli plays an important role in drug transport2004
- Author(s)
  Satoshi Murakami, Norihisa Tamura, Asami Saito, Takahiro Hirata, Akihito Yamaguchi
- Journal Title
  
  The Journal of Biological Chemistry 279
  
  Pages: 3743-3748
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854012
[Journal Article] Membrane topology of ABC-type macrolide antibiotic exporter MacB in Escherichia coli2003
- Author(s)
  Nobuyoshi Kobayashi, Kunihiko Nishino, Takahiro Hirata, Akihito Yamaguchi
- Journal Title
  
  FEBS Letter 546
  
  Pages: 241-246
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142205
[Journal Article] Membrane topology of ABC-type macrolide antibiotic exporter MacB in Escherichia coli2003
- Author(s)
  Nobuyoshi Kobayashi, Kunihiko Nishino, Takahiro Hirata, Akihito Yamaguchi
- Journal Title
  
  FEBS Letter 546
  
  Pages: 241-246
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854012
[Journal Article] beta-Lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli2003
- Author(s)
  Hidetada Hirakawa, Kunihiko Nishino, Junko Yamada, Takahiro Hirata, Akihito Yamaguchi
- Journal Title
  
  Journal of Antimicrobial Chemotherapy 52
  
  Pages: 576-582
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854012
[Journal Article] beta-Lactam resistance modulated by the overexpression o response regulators of two-component signal transduction systems in Escherichia coli2003
- Author(s)
  Hidetada Hirakawa, Kunihiko Nishino, Junko Yamada, Takahiro Hirata, Akihito Yamaguchi
- Journal Title
  
  Journal of Antimicrobial Chemotherapy 52
  
  Pages: 576-582
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142205
[Journal Article] Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli2003
- Author(s)
  Hidetada Hirakawa, Kunihiko Nishino, Takahiro Hirata, Akihito Yamaguchi
- Journal Title
  
  Journal of Bacteriology 185
  
  Pages: 1851-1856
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854012
[Journal Article] Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to beta-lactams2003
- Author(s)
  Kunihiko Nishino, Junko Yamada, Hidetada Hirakawa, Takahiro Hirata, Akihito Yamaguchi
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 47
  
  Pages: 3030-3033
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854012
[Journal Article] Roles of To1C-dependent multidrug transporters of Escherichia col in resistance to beta-lactams2003
- Author(s)
  Kunihiko Nishino, Junko Yamada, Hidetada Hirakawa, Takahiro Hirata, Akihito Yamaguchi
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 47
  
  Pages: 3030-3033
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142205
[Journal Article] Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli2003
- Author(s)
  Hidetada Hirakawa, Kunihiko Nishino, Takahiro Hirata, Akihito Yamaguchi
- Journal Title
  
  Journal of Bacteriology 185
  
  Pages: 1851-1856
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142205
[Journal Article] The putative response regulator BaeR stimulates multidrug resistance of Escherichia coil via a novel multidrug exporter system, MdtABC2002
- Author(s)
  Satoshi Nagakubo, Kunihiko Nishino, Takahiro Hirata, Akihito Yamaguchi
- Journal Title
  
  Journal of Bacteriology 184
  
  Pages: 4161-4167
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854012
[Journal Article] The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC2002
- Author(s)
  Satoshi Nagakubo, Kunihiko Nishino, Takahiro Hirata, Akihito Yamaguchi
- Journal Title
  
  Journal of Bacteriology 184
  
  Pages: 4161-4167
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142205
[Presentation] Polar localization of a drug efflux transporter, MacB, in Escherichia coli2009
- Author(s)
  平田隆弘他
- Organizer
  109th American Society of Microbiology General Meeting
- Place of Presentation
  米国フィラデルフィア
- Year and Date
  2009-05-18
- Data Source
  KAKENHI-PROJECT-18590055
[Presentation] 大腸菌薬剤排出タンパク質の細胞内局在2008
- Author(s)
  平田隆弘他
- Organizer
  日本薬学会第128 年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590055
[Presentation] 大腸菌薬剤排出タンパク質の細胞内局在2008
- Author(s)
  平田隆弘, 他
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590055
[Presentation] 大腸菌異物排出蛋白質MacAB の極への局在2007
- Author(s)
  平田隆弘他
- Organizer
  大腸菌研究会
- Place of Presentation
  静岡
- Year and Date
  2007-07-18
- Data Source
  KAKENHI-PROJECT-18590055
[Presentation] 大腸菌バイオフィルム形成機構に関与する新規遺伝子産物に関する研究2007
- Author(s)
  王麗媛、平田隆弘, 他
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-18590055
[Presentation] 大腸菌異物排出蛋白質MacABの極への局在2007
- Author(s)
  平田隆弘, 他
- Organizer
  大腸菌研究会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-18590055
[Presentation] 大腸菌バイオフィルム形成機構に関与する新規遺伝子産物に関する研究2007
- Author(s)
  王麗媛、平田隆弘他
- Organizer
  第30 回日本分子生物学会年会・第80 回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-18590055
[Presentation] The regulatory mechanism of the AcrAB and AcrEF multidrug exporter system by AcrS,in Escherichia coli2007
- Author(s)
  平川秀忠、平田隆弘, 他
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-18590055
[Presentation] The regulatory mechanism of the AcrAB and AcrEF multidrug exporter system by AcrS, in Escherichia coli2007
- Author(s)
  平川秀忠、平田隆弘他
- Organizer
  第30 回日本分子生物学会年会・第80 回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-18590055

1. YAMAGUCHI Akihito (60114336)

# of Collaborated Projects: 2 results

# of Collaborated Products: 24 results
2. MURAKAMI Satoshi (30300966)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. 木村能章

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIRATA Takahiro 平田 隆弘

Research Projects

Research Products

Co-Researchers

Physiological functions of bacterial efflux transportersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the crystal structure of antiporters for organic compounds and the mechanisms

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Post-Genomic Approach to Bacterial Xenobiotic Exporter Gene Resources and Investigation of Novel Drug Resistance Mechanisms of Bacteria

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] CBT対策と演習 生化学2009

Author(s)

Total Pages

Publisher

Data Source

[Book] 薬学領域における病原微生物学・感染症学・化学療法学2007

Author(s)

Total Pages

Publisher

Data Source

[Book] 薬学領域における病原微生物学・感染症学・化学療法学2007

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] AcrS/EnvR represses expression of the acrAB multidrug efflux genes in Escherichia coli2008

Author(s)

Journal Title

Data Source

[Journal Article] Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] N-acetyl-D-glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite activation in Escherichia coli2006

Author(s)

Journal Title

Data Source

[Journal Article] Growth phase-dependent expression of drug exporters in Escherichia coli and its contribution to drug tolerance2006

Author(s)

Journal Title

Data Source

[Journal Article] N-acetyl-d-glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite activation in Escherichia coli2006

Author(s)

Journal Title

Data Source

[Journal Article] Indole induces the expression of multidrug exporter genes in Escherichia coli2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Indole induces the expression of multidrug exporter genes in Escherichia coli2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Indole induces the expression of multidrug exporter genes in Escherichia coil.2005

Author(s)

Journal Title

Data Source

[Journal Article] Indole induces the expression of multidrug exporter genes in Esche richia coli.2005

Author(s)

Journal Title

HIRATA Takahiro 平田隆弘

[Book] CBT対策と演習生化学2009