TATSUYA Dezaki 出崎克也

… Alternative Names

DEZAKI Katsuya 出崎克也

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Researcher Number	90337329
Other IDs
External Links
Affiliation (Current)	2025: 医療創生大学, 薬学部, 教授 2025: 自治医科大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help	2020 – 2024: 医療創生大学, 薬学部, 教授 2015 – 2019: 自治医科大学, 医学部, 准教授 2009 – 2013: Jichi Medical University, 医学部, 准教授 2007 – 2008: Jichi Medical University, School of Medicine, Associate Professur 2002 – 2006: 自治医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 54040:Metabolism and endocrinology-related / Biological Sciences / General physiology Except Principal Investigator General physiology / Biological Sciences
Keywords	Principal Investigator インスリン分泌 / 糖尿病 / 生理学 / 糖代謝 / シグナル伝達 / インスリン / グレリン / TRPM2 / CD38 / 視床下部 … More / カチオンチャネル / グルカゴン / オキシトシン / 遺伝子改変動物 / 血糖値 / β細胞 / 細胞内Ca^<2+> / GHS-R … More Except Principal Investigator グレリン / 弓状核 / NPY / leptin / NPYニューロン / 摂食 / レプチン / カルシウム / 膵島 / インスリン分泌 / 室傍核 / CRH / BDNF / ghrelin / 摂食中枢 / インスリン / β細胞 / グルコース / Kチャネル / GKラット / 視交叉上核 / 細胞情報伝達 / インスリン感受性 / 高感受性 / PDK1 / PDK１ / オキシトシン神経 / 神経内分泌 / 視床下部 / urocortin / glucose / feeding / レぷちん / Ca^<2+> / ウロコルチン / NPY neuron / feeding center / plasma glucose / cytosolic Ca^<2+> / β-cells / insulin release / Ca / 膵灌流 / 血糖値 / カルシウムイオン / hyperphagia / GK rat / insulin / HMG CoA reductase inhibitor / fatty acid / resistin / visceral fat / ホスホリパーゼC / 膵β細胞 / オレイン酸 / 肥満 / PACAP / オレキシン / 血小板凝集 / 脂肪細胞 / GPR40 / インスリン抵抗性 / 脂肪細胞分化 / 内臓脂肪蓄積 / カンナビノイド / Nesfatin-1 / 過食 / HMG CoA還元酵素阻害剤 / 脂肪酸 / レジスチン / 内臓脂肪 / GHS-R / グレリン受容体 / HS-R / 膵島G / 糖代謝 / Kvチャネル / cAMP Less

CD38/TRPM2を介したGLP-1のインスリン分泌促進とβ細胞保護作用メカニズムの解明Principal Investigator
- Principal Investigator
  
  出崎克也
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Iryo Sosei University
Regulation of glucose metabolism by oxytocin via insulin secretionPrincipal Investigator
- Principal Investigator
  
  Dezaki Katsuya
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Iryo Sosei University
  Jichi Medical University
Molecular mechanism for highly sensitive response to peripheral hormones in hypothalamic neurons and homeostatic role
- Principal Investigator
  
  Yada TOSHIHIKO
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical University
Pathophysiological role of ghrelin in impaired GLP-1 secretion in tyte 2 diabetesPrincipal Investigator
- Principal Investigator
  
  Dezaki Katsuya
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Glucose metabolism in ghrelin conditional KO micePrincipal Investigator
- Principal Investigator
  
  DEZAKI Katsuya
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
グルコースとホルモン情報を統合する膵β細胞Kv・TRPチャネルのセンサー機構Principal Investigator
- Principal Investigator
  
  出崎克也
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Ghrelin : its status as a pancreatic hormone, mechanisms by which it regulates insulin release and glucose metabolism, and its application for treating diabetes.
- Principal Investigator
  
  YADA Toshihiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical University
Effective strategy to treat type 2 diabetes by blockade of ghrelin signaling in islet β-cellsPrincipal Investigator
- Principal Investigator
  
  DEZAKI Katsuya
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
TRP・Kvチャネルを介した新規グルコースセンシング-インスリン分泌連関Principal Investigator
- Principal Investigator
  
  出崎克也
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
遺伝子改変技術を用いての膵島内因性グレリンによるインスリン分泌抑制機構の解明Principal Investigator
- Principal Investigator
  
  出崎克也
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Inputs and outputs of NPY and BDNF neurons in the hypothalamus and their implication in feeding and metabolic regulation
- Principal Investigator
  
  YADA Toshihiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical University
Regulation by endogenous ghrelin of insulin release, feeding and glucose metabolism
- Principal Investigator
  
  YADA Toshihiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  JICHI MEDICAL UNIVERSITY
Novel signaling function of adipocytes
- Principal Investigator
  
  YADA Toshihiko
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
グレリンによるインスリン分泌調節機構の解明Principal Investigator
- Principal Investigator
  
  出崎克也
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical University

[Book] 胃全摘と摂食‐ラット胃全摘モデルにおける術式と摂食の関係、術後の摂食低下とグレリン感受性の推移‐.GI Research2013
- Author(s)
  小泉大、出崎克也、田口昌延、安田是和、矢田俊彦
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-23591320
[Book] Ghrelin's novel signaling in isletβ-cells to inhibit insulin secretion and its blockade as a promising strategy to treat type 2 diabetes. Ghrelin in Health and Disease2012
- Author(s)
  Dezaki K, Damdindorj B, Kurashina T, Yada T
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-23591320
[Book] Ghrelin in Health and Disease2012
- Author(s)
  Katsuya Dezaki
- Total Pages
  21
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-23591320
[Book] 糖尿病ナビゲーター(インスリン分泌におけるカルシウムシグナリングの役割)(門脇孝(編))第2版2010
- Author(s)
  出崎克也,中田正範,矢田俊彦
- Publisher
  メディカルビュー社
- Data Source
  KAKENHI-PROJECT-20390061
[Book] インスリン分泌におけるカルシウムシグナリングの役割.In 糖尿病ナビゲーター第2版2010
- Author(s)
  出崎克也
- Publisher
  メディカルビュー社
- Data Source
  KAKENHI-PROJECT-20390061
[Book] 糖尿病学「グレリンによるインスリン分泌」2008
- Author(s)
  出崎克也
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-20390061
[Book] グレリンによるインスリン分泌制御In糖尿病学20082008
- Author(s)
  出崎克也, 他
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-20591070
[Book] グレリンによるインスリン分泌制御In糖尿病学20082008
- Author(s)
  出崎克也, 他
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-19045026
[Book] 糖尿病学グレリンによるインスリン分泌2008
- Author(s)
  出崎克也、曽根英行、矢田俊彦
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-20390061
[Book] グレリンによるインスリン分泌制御In糖尿病学20082008
- Author(s)
  出崎克也、曽根英行、矢田俊彦
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-20591070
[Book] 内分泌・糖尿病科:グレリンによるインスリン分泌・血糖値調節機構2007
- Author(s)
  出崎克也
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-15081211
[Book] 内分泌、糖尿病科:グレリンによるインスリン分泌、血糖値調節機構2007
- Author(s)
  出崎克也
- Publisher
  科学評論社25(3)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Book] グレリンと糖脂質代謝2004
- Author(s)
  出崎克也
- Publisher
  日本臨床第2巻増刊号9
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390053
[Book] 日本臨床第62巻増刊号92004
- Author(s)
  出崎克也
- Data Source
  KAKENHI-PROJECT-16390053
[Journal Article] A novel mechanism of imeglimin‐mediated insulin secretion via the cADPR‐TRP channel pathway2022
- Author(s)
  Funazaki Shunsuke、Yoshida Masashi、Yamada Hodaka、Kakei Masafumi、Kawakami Masanobu、Nagashima Shuichi、Hara Kazuo、Dezaki Katsuya
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 13 Issue: 1 Pages: 34-41
- DOI
  10.1111/jdi.13669
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08524, KAKENHI-PROJECT-18K08525, KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-19K18012
[Journal Article] Muscle mass evaluation using psoas muscle mass index by computed tomography imaging in hemodialysis patients2021
- Author(s)
  Kiyonori Ito, Susumu Ookawara, Sojiro Imai, Hideo Kakuda, Yusaku Bandai, Mariko Fueki, Masatoshi Yasuda, Tatsuya Kamimura, Satoshi Kiryu, Noriko Wada, Yuri Hamashima, Mitsutoshi Shindo, Tadanao Kobayashi, Hidenori Sanayama, Yoshio Kaku, Keisuke Tanno, Yasushi Ohnishi, Noriaki Iino, Katsuya Dezaki　他
- Journal Title
  
  Clinical Nutrition ESPEN
  
  Volume: 44: Pages: 410-414
- DOI
  10.1016/j.clnesp.2021.04.029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08524
[Journal Article] ASC regulates platelet activation and contributes to thrombus formation independent of NLRP3 inflammasome2020
- Author(s)
  Watanabe Sachiko、Usui-Kawanishi Fumitake、Komada Takanori、Karasawa Tadayoshi、Kamata Ryo、Yamada Naoya、Kimura Hiroaki、Dezaki Katsuya、Ohmori Tsukasa、Takahashi Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 531 Issue: 2 Pages: 125-132
- DOI
  10.1016/j.bbrc.2020.07.063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-18K08524, KAKENHI-PROJECT-19K06358, KAKENHI-PROJECT-20K07365, KAKENHI-PROJECT-20K17290, KAKENHI-PROJECT-17K09889, KAKENHI-PROJECT-18K08370
[Journal Article] β-Cell-specific deletion of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase causes overt diabetes due to reduction of β-cell mass and impaired insulin secretion.2020
- Author(s)
  Takei Shoko, Nagashima Shuichi, Takei Akihito, Yamamuro Daisuke, Wakabayashi Tetsuji, Murakami Akiko, Isoda Masayo, Yamazaki Hisataka, Ebihara Chihiro, Takahashi Manabu, Ebihara Ken, Dezaki Katsuya, Takayanagi Yuki, Onaka Tatsushi, Fujiwara Ken, Yashiro Takashi, Ishibashi Shun
- Journal Title
  
  Diabetes
  
  Volume: 69 Issue: 11 Pages: 2352-2363
- DOI
  10.2337/db19-0996
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08524, KAKENHI-PROJECT-20K07249, KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-17K08517, KAKENHI-PROJECT-17K09865, KAKENHI-PROJECT-19H03712
[Journal Article] Ninjin'yoeito targets distinct Ca2+ channels to activate ghrelin-responsive vs. unresponsive NPY neurons in the arcuate nucleus.2020
- Author(s)
  Goswami Chayon, Dezaki Katsuya, Wang Lei, Inui Akio, Seino Yutaka, Yada Toshihiko
- Journal Title
  
  Frontiers in Nutrition
  
  Volume: 7 Pages: 1-10
- DOI
  10.3389/fnut.2020.00104
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08524, KAKENHI-PROJECT-19K22611, KAKENHI-PROJECT-19H04045
[Journal Article] ホルモンによる膵島機能制御2019
- Author(s)
  稲垣暢也、出崎克也、原田直樹、原田範雄
- Journal Title
  
  Islet Equality
  
  Volume: 8 Pages: 5-15
- Data Source
  KAKENHI-PROJECT-18K08524
[Journal Article] Ninjin-yoeito activates ghrelin-responsive and unresponsive NPY neurons in the arcuate nucleus and counteracts cisplatin-induced anorexia2019
- Author(s)
  Goswami Chayon、Dezaki Katsuya、Wang Lei、Inui Akio、Seino Yutaka、Yada Toshihiko
- Journal Title
  
  Neuropeptides
  
  Volume: - Pages: 58-64
- DOI
  10.1016/j.npep.2019.03.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09397, KAKENHI-PROJECT-18K08524, KAKENHI-PROJECT-19K22611, KAKENHI-PROJECT-19H04045
[Journal Article] Weaning stage hyperglycemia induces glucose-insensitivity in arcuate POMC neurons and hyperphagia in type 2 diabetic GK rats2018
- Author(s)
  Ando Akihiko、Gantulga Darambazar、Nakata Masanori、Maekawa Fumihiko、Dezaki Katsuya、Ishibashi Shun、Yada Toshihiko
- Journal Title
  
  Neuropeptides
  
  Volume: 68 Pages: 49-56
- DOI
  10.1016/j.npep.2018.02.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09397, KAKENHI-PROJECT-18K11028, KAKENHI-PROJECT-15K09442
[Journal Article] GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose2018
- Author(s)
  Iwasaki Yusaku、Sendo Mio、Dezaki Katsuya、Hira Tohru、Sato Takehiro、Nakata Masanori、Goswami Chayon、Aoki Ryohei、Arai Takeshi、Kumari Parmila、Hayakawa Masaki、Masuda Chiaki、Okada Takashi、Hara Hiroshi、Drucker Daniel J.、Yamada Yuichiro、Tokuda Masaaki、Yada Toshihiko
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 113-113
- DOI
  10.1038/s41467-017-02488-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09397, KAKENHI-PROJECT-15K09442, KAKENHI-PROJECT-26460302, KAKENHI-PROJECT-16K08497
[Journal Article] Endogenous α2A-adrenoceptor-operated sympathoadrenergic tones attenuate insulin secretion via cAMP/TRPM2 signaling.2017
- Author(s)
  Ito K, Dezaki K, Yoshida M, Yamada H, Miura R, Rita RS, Ookawara S, Tabei K, Kawakami M, Hara K, Morishita Y, Yada T, Kakei M
- Journal Title
  
  Diabetes
  
  Volume: 66(3) Issue: 3 Pages: 699-709
- DOI
  10.2337/db16-1166
- NAID
  40021363366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670453, KAKENHI-PROJECT-15K09396, KAKENHI-PROJECT-15K09397, KAKENHI-PROJECT-16K15182, KAKENHI-PROJECT-16K19545
[Journal Article] Involvement of thermosensitive TRP channels in energy metabolism2017
- Author(s)
  Uchida Kunitoshi、Dezaki Katsuya、Yoneshiro Takeshi、Watanabe Tatsuo、Yamazaki Jun、Saito Masayuki、Yada Toshihiko、Tominaga Makoto、Iwasaki Yusaku
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 67 Issue: 5 Pages: 549-560
- DOI
  10.1007/s12576-017-0552-x
- NAID
  40021301972
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09397, KAKENHI-PLANNED-15H05928, KAKENHI-PROJECT-16H01877, KAKENHI-PROJECT-16K15485, KAKENHI-PROJECT-26670104
[Journal Article] Inhibition of Y1 receptor signaling improves islet transplant outcome2017
- Author(s)
  Loh Kim、Shi Yan-Chuan、Walters Stacey、Bensellam Mohammed、Lee Kailun、Dezaki Katsuya、Nakata Masanori、Ip Chi Kin、Chan Jeng Yie、Gurzov Esteban N.、Thomas Helen E.、Waibel Michaela、Cantley James、Kay Thomas W.、Yada Toshihiko、Laybutt D. Ross、Grey Shane T.、Herzog Herbert
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 490-490
- DOI
  10.1038/s41467-017-00624-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09397, KAKENHI-PROJECT-15K09442
[Journal Article] Involvement of cAMP-EPAC-TRPM2 activation in glucose- and incretin-induced insulin secretion2014
- Author(s)
  Yoshida M, Dezaki K, Uchida K, Kodera S, Lam NV, Ito K, Rita RS, Yamada H, Shimomura K, Ishikawa SE, Sugawara H, Kawakami M, Tominaga M, Yada T, Kakei M
- Journal Title
  
  Diabetes
  
  Volume: (Epub ahead of print) Issue: 10 Pages: 3394-3403
- DOI
  10.2337/db13-1868
- NAID
  40020531124
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591320, KAKENHI-PROJECT-24591340, KAKENHI-PROJECT-24890219, KAKENHI-PROJECT-26460916, KAKENHI-PROJECT-26870532
[Journal Article] A new experimental model of ATP-sensitive K<sup>+</sup> channel-independent insulinotropic action of glucose: a permissive role of cAMP for triggering of insulin release from rat pancreatic β-cells2013
- Author(s)
  Masahiro Takei
- Journal Title
  
  Endocr J
  
  Volume: 60 Issue: 5 Pages: 599-607
- DOI
  10.1507/endocrj.EJ12-0388
- NAID
  10031184527
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591128, KAKENHI-PROJECT-22591853, KAKENHI-PROJECT-23591320, KAKENHI-PROJECT-25461383
[Journal Article] The ghrelin function in insulin release and glucose metabolism.2013
- Author(s)
  Katsuya Dezaki
- Journal Title
  
  Endocr Dev
  
  Volume: 25 Pages: 135-143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591320
[Journal Article] Islet β-cell ghrelin signaling for inhibition of insulin secretion.2012
- Author(s)
  Katsuya Dezaki
- Journal Title
  
  Methods Enzymol
  
  Volume: 514 Pages: 317-331
- DOI
  10.1016/b978-0-12-381272-8.00020-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591320
[Journal Article] Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet β-cells2012
- Author(s)
  Damdindorj B, Dezaki K, Kurashina T, Sone H, Rita R, Kakei M, Yada T
- Journal Title
  
  FEBS Lett
  
  Volume: 586(16) Issue: 16 Pages: 2555-2562
- DOI
  10.1016/j.febslet.2012.06.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390044, KAKENHI-PROJECT-23591320, KAKENHI-PROJECT-24659101, KAKENHI-PUBLICLY-23115715
[Journal Article] Early-phase occurrence of K+ and Cl- efflux in addition to Ca2+ mobilization is a prerequisite to apoptosis in HeLa cells.2012
- Author(s)
  出崎克也、前野恵美、佐藤かお理、秋田天平、岡田泰伸
- Journal Title
  
  Apoptosis
  
  Volume: 17 Issue: 8 Pages: 821-831
- DOI
  10.1007/s10495-012-0716-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249010, KAKENHI-PROJECT-23591320, KAKENHI-PROJECT-23612008
[Journal Article] Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice2011
- Author(s)
  Uchida K., Dezaki K., Damdindorj B., Inada H., Shiuchi T., Mori Y., Yada T., Minokoshi Y., Tominaga M.
- Journal Title
  
  Diabetes 60
  
  Pages: 119-126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390061
[Journal Article] Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice.2011
- Author(s)
  Uchida K, Dezaki K, Damdindorj B, Inada H, Shiuchi T, Mori Y, Yada T, Minokoshi Y, Tominaga M.
- Journal Title
  
  Diabetes 60
  
  Pages: 119-126
- Data Source
  KAKENHI-PROJECT-20591070
[Journal Article] Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in isletβ-cells2011
- Author(s)
  Dezaki K, Damdindorj B, Sone H, Dyachok O, Tengholm A, Gylfe E, Kurashina T, Yoshida M, Kakei M, Yada T
- Journal Title
  
  Diabetes
  
  Volume: 60 Issue: 9 Pages: 2315-2324
- DOI
  10.2337/db11-0368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591320
[Journal Article] Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells.2011
- Author(s)
  Katsuya Dezaki
- Journal Title
  
  Diabetes
  
  Volume: 60 Pages: 2315-2324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591320
[Journal Article] Voltage-dependent metabolic regulation of Kv2.1 channels in pancreatic υ-cells.2010
- Author(s)
  Yoshida M, Nakata M, Yamato S, Dezaki K, Sugawara H, Ishikawa SE, Kawakami M, Yada T, Kakei M.
- Journal Title
  
  Biochem Biophys Res Commun 396
  
  Pages: 304-309
- Data Source
  KAKENHI-PROJECT-20591070
[Journal Article] Reconstruction- dependent recovery from anorexia and time-related recovery of regulatory ghrelin system in gastrectomized rats.2010
- Author(s)
  Koizumi M, Dezaki K, Hosoda H, Damdindorj B, Sone H, Ming L, Hosoya Y, Sata N, Kobayashi E, Kangawa K, Nagai H, Yasuda Y, Yada T.
- Journal Title
  
  Int J Pept
- Data Source
  KAKENHI-PROJECT-20591070
[Journal Article] Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis.2010
- Author(s)
  Yoshida N, Maejima Y, Sedbazar U, Ando A, Kurita H, Damdindorj B, Takano E, Gantulga D, Iwasaki Y, Kurashina T, Onaka T, Dezaki K, Nakata M, Mori M, Yada T.
- Journal Title
  
  Aging 2
  
  Pages: 775-784
- Data Source
  KAKENHI-PROJECT-20591070
[Journal Article] Reconstruction-dependent recovery from anorexia and time-related recovery of regulatory ghrelin system in gastrectomized rats2010
- Author(s)
  Koizumi M., Dezaki K., Hosoda H., Damdindorj B., Sone H., Ming L., Hosoya Y., Sata N., Kobayashi E., Kangawa K., Nagai H., Yasuda Y., Yada T.
- Journal Title
  
  International J. Peptides 2010
  
  Pages: 10-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390061
[Journal Article] Voltage-dependent metabolic regulation of Kv2.1 channels in pancreatic β-cells2010
- Author(s)
  Yoshida M., Nakata M., Yamato S., Dezaki K., Sugawara H., Ishikawa S., Kawakami M., Yada T., Kakei M.
- Journal Title
  
  Biochem.Biophys.Res.Commun 396
  
  Pages: 304-309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390061
[Journal Article] Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin- independent melanocortin pathway.2009
- Author(s)
  Maejima Y, Sedbazar U, Suyama S, Kohno D, Onaka T, Takano E, Yoshida N, Koike M, Uchiyama Y, Fujiwara K, Yashiro T, Horvath TL, Dietrich MO, Tanaka S, Dezaki K, Oh-I S, Hashimoto K, Shimizu H, Nakata M, Mori M, Yada T.
- Journal Title
  
  Cell Metab 10
  
  Pages: 355-365
- Data Source
  KAKENHI-PROJECT-20591070
[Journal Article] Regulation of voltage-gated K^+ channels by glucose metabolism in pancreatic υ-cells.2009
- Author(s)
  Yoshida M, Dezaki K, Yamato S, Aoki A, Sugawara H, Toyoshima H, Ishikawa SE, Kawakami M, Nakata M, Yada T, Kakei M.
- Journal Title
  
  FEBS Lett 583
  
  Pages: 2225-2230
- Data Source
  KAKENHI-PROJECT-20591070
[Journal Article] Regulation of voltage-gated K^+ channels by glucose metabolism in pancreatic β-cells2009
- Author(s)
  Yoshida M., Dezaki K., Yamato S., Aoki A., Sugawara H., Toyoshima H., Ishikawa S., Kawakami M., Nakata M., Yada T., Kakei M.
- Journal Title
  
  FEBS Lett 583
  
  Pages: 2225-2230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390061
[Journal Article] Neuropeptide W in the rat pancreas: potentiation of glucose-induced insulin release and Ca^<2+> influx through L-type Ca^<2+> channels in υ-cells and localization in islets.2008
- Author(s)
  Dezaki K, Kageyama H, Seki M, Shioda S, Yada T.
- Journal Title
  
  Regul Pept 145
  
  Pages: 153-158
- Data Source
  KAKENHI-PROJECT-20591070
[Journal Article] Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis.2008
- Author(s)
  出崎克也, 他
- Journal Title
  
  Pharmacol. Ther. 118
  
  Pages: 239-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591070
[Journal Article] Neuropeptide W in the rat pancreas: potentiation of glucose-induced insulin release and Ca^<2+> influx through L-type Ca^<2+> channels in β-cells and localization in islets.2008
- Author(s)
  Dezaki K
- Journal Title
  
  Regulatory Peptides 145
  
  Pages: 153-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15081211
[Journal Article] Neuropeptide W in the rat pancreas : potentiation of glucose- induced insulin release and Ca^<2+> influx through L-type Ca^<2+> channels in β-cells and localization in islets.2008
- Author(s)
  Dezaki, K
- Journal Title
  
  Regulatory Peptides 145
  
  Pages: 153-158
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Ghrelin regulates insulin release and glycemia : Physiological role and therapeutic potential.2008
- Author(s)
  Yada T, Dezaki K, Sone H, Koizumi M, Damdindorj B, Nakata M, Kakei M.
- Journal Title
  
  Curr Diabetes Rev 4
  
  Pages: 18-23
- Data Source
  KAKENHI-PROJECT-20591070
[Journal Article] Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis.2008
- Author(s)
  Dezaki K
- Journal Title
  
  Pharmacol. Therapeut. 118
  
  Pages: 239-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390061
[Journal Article] Neuropeptide W in the rat pancreas : potentiation of glucose-induced insulin releaseand Ca^<2+> influx through L-type Ca^<2+> channels in β-cells and localization in islets.2008
- Author(s)
  出崎克也, 他
- Journal Title
  
  Regul. Pept. 145
  
  Pages: 153-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591070
[Journal Article] Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis2008
- Author(s)
  出崎克也, 他
- Journal Title
  
  Pharmacol. Ther 118
  
  Pages: 239-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19045026
[Journal Article] Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding.2008
- Author(s)
  Kohno D, Nakata M, Maejima Y, Shimizu H, Sedbazar U, Dezaki K, Yoshida N, Onaka T, Mori M, Yada T.
- Journal Title
  
  Endocrinology 149
  
  Pages: 1295-1301
- Data Source
  KAKENHI-PROJECT-20591070
[Journal Article] Neuropeptide W in the rat pancreas : potentiation of glucose-induced insulin release and Ca^<2+> influx through L-type Ca^<2+> channels in β-cells and localization in islets2008
- Author(s)
  出崎克也, 他
- Journal Title
  
  Regul. Pept 145
  
  Pages: 153-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19045026
[Journal Article] Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis.2008
- Author(s)
  Dezaki, K
- Journal Title
  
  Pharmacol Ther. Mar 10 (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis.2008
- Author(s)
  Dezaki K, Sone H, Yada T.
- Journal Title
  
  Pharmacol Ther 118
  
  Pages: 239-249
- Data Source
  KAKENHI-PROJECT-20591070
[Journal Article] Neuropeptide W in the rat pancreas: potentiation of glucose- induced insulin release and Ca^<2+> influx through L-type Ca^<2+> channels in β-cells and localization in islets2008
- Author(s)
  Dezaki K
- Journal Title
  
  Regulatory Peptides 145
  
  Pages: 153-158
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis2008
- Author(s)
  Dezaki K., Sone H., Yada T.
- Journal Title
  
  Pharmacol.Ther 118
  
  Pages: 239-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390061
[Journal Article] Ghrelin uses Gα_<i2> and activates voltage-dependent K^+ channels to attenuate glucose-induced Ca^<2+> signaling and insulin release in islet β-cells: novel signal transduction of ghrelin.2007
- Author(s)
  Dezaki K
- Journal Title
  
  Diabetes 56
  
  Pages: 2319-2327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15081211
[Journal Article] Ghrelin uses Gα_<i2> and activates voltage-dependent K^+ channels to attenuate glucose-induced Ca^<2+> signaling and insulin release in islet β-cells: Novel signal transduction of ghrelin.2007
- Author(s)
  出崎克也, 他
- Journal Title
  
  Diabetes 56
  
  Pages: 2319-2327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19045026
[Journal Article] Ghelin uses Gα_<i2> and activates voltage-dependent K^+ channels to attenuate glucose-induced Ca^<2+> signaling and insulin release in islet β-cells: novel signal transduction of ghrelin2007
- Author(s)
  Dezaki K
- Journal Title
  
  Diabetes 56
  
  Pages: 2319-2327
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Ghrelin uses Ga_12 and activates voltage-dependent K^+ channels to attenuate glucose-induced Ca^<2+> signaling and insulin release in islet β-cells : novel signal transduction of ghrelin.2007
- Author(s)
  Dezaki, K
- Journal Title
  
  Diabetes 56
  
  Pages: 2319-2327
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Ghrelin uses Gα_<i2> and activates voltage-dependent K^+ channels to attenuate glucose-induced Ca^<2+> signaling and insulin release in islet β-cells: Novel signal transduction of ghrelin.2007
- Author(s)
  出崎克也, 他
- Journal Title
  
  Diabetes 56
  
  Pages: 2319-2327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790623
[Journal Article] グレリンによるインスリン分泌・血糖値調節機構2007
- Author(s)
  出崎克也, 他
- Journal Title
  
  内分泌・糖尿病科 25
  
  Pages: 239-244
- Data Source
  KAKENHI-PROJECT-19045026
[Journal Article] Ghrelin uses Gα_i2 and activates voltage-dependent K^+ channels to attenuate glucose-induced Ca^<2+> signaling and insulin release in islet R-cells:novel signal transduction of ghrelin.2007
- Author(s)
  Dezaki K
- Journal Title
  
  Diabetes 56
  
  Pages: 2319-2327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Mechanisms of regulation of insulin release and glucose metabolism by ghrelin2007
- Author(s)
  Dezaki, K
- Journal Title
  
  Endocrinology & Diabetology
  
  Pages: 239-244
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] グレリンによるインスリン分泌・血糖値調節機構2007
- Author(s)
  出崎克也, 他
- Journal Title
  
  内分泌・糖尿病科 25
  
  Pages: 239-244
- Data Source
  KAKENHI-PROJECT-18790623
[Journal Article] Ghrelin uses Gα_2 and activates voltage-dependent K^+ channels to attenuate glucose-induced Ca^<2+> signaling and insulin release in islet β-cells : novel signal transduction of ghrelin2007
- Author(s)
  Dezaki K
- Journal Title
  
  Diabetes 56
  
  Pages: 2319-2327
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15081211
[Journal Article] Ghrelin uses Gα_<i2> and activates voltage-dependent K^+ channels to attenuate glucose-induced Ca^<2+> signaling and insulin release in islet β-cells : novel signal transduction of ghrelin.2007
- Author(s)
  Dezaki K
- Journal Title
  
  Diabetes 56
  
  Pages: 2319-2327
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15081211
[Journal Article] Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance2006
- Author(s)
  Dezaki K
- Journal Title
  
  Diabetes 55
  
  Pages: 3486-3493
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15081211
[Journal Article] Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance.2006
- Author(s)
  Dezaki, K
- Journal Title
  
  Diabetes 55
  
  Pages: 3486-3493
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance2006
- Author(s)
  出崎克也他
- Journal Title
  
  Diabetes 55・12
  
  Pages: 3483-3493
- Data Source
  KAKENHI-PROJECT-18790623
[Journal Article] Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance.2006
- Author(s)
  Dezaki K
- Journal Title
  
  Diabetes 55
  
  Pages: 3486-3493
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15081211
[Journal Article] Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance2006
- Author(s)
  Dezaki K
- Journal Title
  
  Diabetes 55
  
  Pages: 3486-3493
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance.2006
- Author(s)
  Dezaki K
- Journal Title
  
  Diabetes 55
  
  Pages: 3486-3493
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca^<2+> signaling in β-cells : implication in the glycemic control in rodents2004
- Author(s)
  Dezaki K
- Journal Title
  
  Diabetes 53
  
  Pages: 3142-3151
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390053
[Journal Article] Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca^2+ signaling in β-cells : implication in the glycemic control in rodents.2004
- Author(s)
  Dezaki K
- Journal Title
  
  Diabetes 53
  
  Pages: 3142-3151
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390053
[Journal Article] Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca^<2+> signaling in β-cells : implication in the glycemic control in rodents.2004
- Author(s)
  Dezaki K
- Journal Title
  
  Diabetes 53
  
  Pages: 3142-3151
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15081211
[Journal Article] Ghrelin in the regulation of glucose and lipid metabolism.2004
- Author(s)
  Dezaki K, Yada T
- Journal Title
  
  Nippon Rinsho. Sep ; 62 Suppl 9
  
  Pages: 388-391
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390053
[Journal Article] Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca^<2+> signaling in β-cells : implication in the glycemic control in rodents2004
- Author(s)
  Dezaki K
- Journal Title
  
  Diabetes 53
  
  Pages: 3142-3151
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15081211
[Journal Article] Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca^<2+> signaling in β-cells : implication in the glycemic control in rodents.2004
- Author(s)
  Dezaki K
- Journal Title
  
  Diabetes 53
  
  Pages: 3142-3151
- Data Source
  KAKENHI-PROJECT-16390053
[Journal Article] Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis
- Author(s)
  Dezaki K
- Journal Title
  
  Pharmacol Ther (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390065
[Patent] 組成物?保護/再生促進組成物?及びCamp産生促進組成物2009
- Inventor(s)
  矢田俊彦(届出・代表)、出崎克也
- Industrial Property Rights Holder
  自治医科大学
- Filing Date
  2009-05-27
- Data Source
  KAKENHI-PROJECT-20390061
[Patent] 組成物、保護/再生促進組成物、及びcAMP産生促進組成物2009
- Inventor(s)
  矢田俊彦(届出・代表)、出崎克也
- Industrial Property Rights Holder
  自治医科大学
- Filing Date
  2009-05-27
- Data Source
  KAKENHI-PROJECT-20591070
[Presentation] 消化管ホルモンによるTRPM2を介したインスリン分泌調節2021
- Author(s)
  出崎　克也
- Organizer
  第43回東北薬学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K08524
[Presentation] 膵β細胞GPR40シグナルはTRPチャネル活性化を介してKATP非依存性にインスリン分泌を増強する2019
- Author(s)
  山田穂高, 船崎俊介, 吉田昌史, 伊藤聖学, 出崎克也, 川上正舒, 石川三衛, 加計正文, 原一雄
- Organizer
  第62回日本糖尿病学会年次学術集会学会
- Data Source
  KAKENHI-PROJECT-18K08524
[Presentation] Gq-mediated activation of non-selective cation channels in insulin releasing b-cells2019
- Author(s)
  Dezaki Katsuya
- Organizer
  FAOPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08524
[Presentation] オキシトシンは膵β細胞の背景電流を増大させグルコース誘発インスリン分泌を促進する2019
- Author(s)
  出崎克也, 吉田昌史, 伊藤聖学, 加計正文, 矢田俊彦
- Organizer
  第62回日本糖尿病学会年次学術集会学会
- Data Source
  KAKENHI-PROJECT-18K08524
[Presentation] オキシトシン経鼻投与は内因性オキシトシン分泌を促進し耐糖能を向上させる2018
- Author(s)
  出崎克也
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08524
[Presentation] 希少糖アルロースによるGLP-1放出、求心性迷走神経を介した摂食・糖代謝制御と肥満症改善．2017
- Author(s)
  矢田俊彦，岩﨑有作，比良徹，原博，Goswami Chayon，仙度光麻，徳田雅明，出崎克也
- Organizer
  第122回日本解剖学会総会・全国学術集会（日本解剖学会・日本生理学会合同シンポジウム）
- Place of Presentation
  長崎大学坂本キャンパス(長崎県長崎市)
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K15182
[Presentation] GLP-1 and ghrelin regulate insulin release via TRPM2 signaling in islet β-cells2017
- Author(s)
  Dezaki　Katsuya
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K09397
[Presentation] オキシトシンはGq-非選択的カチオンチャネル活性化によりβ細胞インスリン分泌を促進する2017
- Author(s)
  出崎　克也
- Organizer
  第94回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-15K09397
[Presentation] オキシトシンによる膵β細胞インスリン分泌促進と耐糖能改善2017
- Author(s)
  出崎　克也
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K09397
[Presentation] オキシトシン点鼻投与による血中インスリン分泌促進と耐糖能改善2016
- Author(s)
  出崎克也
- Organizer
  第37回日本肥満学会
- Place of Presentation
  東京ファッションタウンビル（東京都江東区）
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-15K09397
[Presentation] Na+,K+-ATPase in the hypothalamic arcuate nucleus senses lowering glucose to initiate feeding behavior.2016
- Author(s)
  Yada T, Kurita H, Xu KY, Santoso P, Yang Y, Dezaki K, Nakata M
- Organizer
  46th annual meeting of The Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15182
[Presentation] グレリンのインスリン分泌・糖代謝作用における膵β細胞 vs 全身GHS-Rの役割2016
- Author(s)
  出崎克也
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K09397
[Presentation] グレリンはGLP-1のインクレチン効果を抑制する2014
- Author(s)
  出崎克也
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23591320
[Presentation] GLP-1によるインスリン分泌に対するグレリンの抑制作用2013
- Author(s)
  出崎克也
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23591320
[Presentation] Zucker fatty ラットの肥満初期における血中グレリン動態2013
- Author(s)
  出崎　克也
- Organizer
  第34回日本肥満学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591320
[Presentation] グレリン受容体シグナルとしての膵β細胞Kvチャネル2013
- Author(s)
  出崎克也
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591320
[Presentation] グレリンによる膵β細胞cAMPシグナルを介したインスリン分泌抑制2013
- Author(s)
  出崎克也
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23591320
[Presentation] Zucker fattyラットの肥満初期における血中グレリン動態2013
- Author(s)
  出崎克也
- Organizer
  第34回日本肥満学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591320
[Presentation] グレリンの膵β細胞インスリン分泌抑制作用におけるcAMPシグナルの関与2012
- Author(s)
  出崎克也
- Organizer
  第33回日本肥満学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591320
[Presentation] グレリンによるβ細胞cAMPシグナルを介したグルコース誘発インスリン分泌抑制2012
- Author(s)
  出崎克也
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591320
[Presentation] 膵β細胞イオンチャネルに対するグレリンの効果2011
- Author(s)
  出崎　克也
- Organizer
  第32回日本肥満学会
- Place of Presentation
  淡路
- Data Source
  KAKENHI-PROJECT-23591320
[Presentation] グレリンによる膵ランゲルハンス島β細胞の新しいインスリン分泌制御2011
- Author(s)
  出崎克也
- Organizer
  第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] 2型糖尿病ラット膵β細胞における電位依存性Kv2.1チャネルの発現・機能亢進2011
- Author(s)
  出崎　克也
- Organizer
  第５４回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23591320
[Presentation] グレリンによる膵ランゲルハンス島β細胞の新しいインスリン分泌制御2011
- Author(s)
  出崎克也, 矢田俊彦
- Organizer
  第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会合同大会28-29
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] 膵β細胞Kv2.1チャネルの代謝依存性調節機構2010
- Author(s)
  加計正文, 吉田昌史, 出崎克也, 青木厚, 菅原斉, 豊島秀男, 石川三衛, 川上正舒, 中田正範, 矢田俊彦
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] Kv2.1-channel currents are mediated by phosphorylation of the channels during glucose stimulation2010
- Author(s)
  吉田昌史, 出崎克也, 青木厚, 豊島秀男, 石川三衛, 川上正舒, 中田正範, 矢田俊彦., 加計正文
- Organizer
  The American Diabetes Association 70th scientific sessions Abstracts: Diabetes:59(suppl. 1)A454, 2010
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] Ghrelin is a physiological regulator of insulin release in islet β-cells.2010
- Author(s)
  出崎克也
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-20591070
[Presentation] グレリンによるβ細胞Kv2.1チャネル活性化を介したグルコース誘発インスリン分泌抑制2010
- Author(s)
  出崎克也
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PUBLICLY-21026026
[Presentation] グレリンによるβ細胞Kv2.1チャネル活性化を介したグルコース誘発インスリン分泌抑制2010
- Author(s)
  出崎克也
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-20591070
[Presentation] グレリンによるβ細胞Kv2.1チャネル活性化を介したグルコース誘発インスリン分泌抑制2010
- Author(s)
  出崎克也, Damdindorj Boldbaatar, 加計正文, 矢田俊彦
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] TRPM2とインスリン分泌2010
- Author(s)
  内田邦敏, 出崎克也, Damdindorj Boldbaatar, 森泰生, 箕越靖彦, 矢田俊彦, 富永真琴
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] Ghrelin is a physiological regulator of insulin release in islet β-cells.2010
- Author(s)
  出崎克也
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PUBLICLY-21026026
[Presentation] グレリンによるインスリン分泌制御2010
- Author(s)
  出崎克也
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] グレリンによるインスリン分泌制2010
- Author(s)
  出崎克也, Damdindorj Boldbaatar, 加計正文, 矢田俊彦
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] Ghrelin receptor antagonist improves glucose intolerance in type 2 diabetic GK rats.2010
- Author(s)
  Damdindorj B., Dezaki K., Sone H., Yaguchi T., Kakei M., Yada T.
- Organizer
  14^<th> International Congress of Endocrinology
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] Ghrelin receptor antagonist potentiates glucose-induced insulin release in diabetic GK rats2009
- Author(s)
  Damdindorj B., Dezaki K., Sone H., Kakei M., Yada T.
- Organizer
  The 36th International Congress of Physiological Sciences (IUPS)
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] 2型糖尿病ラット膵島におけるKv2.1チャネルブロッカーによるインスリン分泌促進2009
- Author(s)
  出崎克也, 他
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-03-17
- Data Source
  KAKENHI-PROJECT-19045026
[Presentation] Excessive expression and activity of Kv2.1 channels in islet β-cells of type 2 diabetic GK rats2009
- Author(s)
  Dezaki K., Damdindorj B., Ando A., Yoshida M., Kakei M., Yada T.
- Organizer
  45^<th> EASD Annual Meeting
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] Excessive expression and activity of Kv2.1 channels in islet β-cells of type 2 diabetic GK rats2009
- Author(s)
  出崎克也
- Organizer
  The 45th EASD Annual Meeting
- Place of Presentation
  Vienna
- Year and Date
  2009-09-30
- Data Source
  KAKENHI-PUBLICLY-21026026
[Presentation] Excessive expression and activity of Kv2.1 channels in islet β-cells of type 2 diabetic GK rats.2009
- Author(s)
  出崎克也
- Organizer
  The 45th EASD Annual Meeting
- Place of Presentation
  Vienna
- Year and Date
  2009-09-30
- Data Source
  KAKENHI-PROJECT-20591070
[Presentation] 2型糖尿病ラット膵島におけるKv2.1チャネルブロッカーによるインスリン分泌促進2009
- Author(s)
  出崎克也
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-03-17
- Data Source
  KAKENHI-PROJECT-20591070
[Presentation] Kv2.1 channel blockers enhance glucose-induced cytosolic Ca^<2+> increases and insulin release in pancreatic β-cells of type 2 diabetic rats2009
- Author(s)
  出崎克也
- Organizer
  The XXXVI International Congress of Physiological Sciences
- Place of Presentation
  京都
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-20591070
[Presentation] Kv2.1 channel blockers enhance glucose-induced cytosolic Ca^<2+> increases and insulin release in islet β-cells of type 2 diabetic rats2009
- Author(s)
  Dezaki K
- Organizer
  The 36th International Congress of Physiological Sciences(IUPS)
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] Excessive expression and activity of Kv2.1 channels in islet β-cells of type 2 diabetic GK rats2009
- Author(s)
  出崎克也
- Organizer
  The 45th EASD Annual Meeting
- Place of Presentation
  Vienna
- Year and Date
  2009-09-30
- Data Source
  KAKENHI-PROJECT-20591070
[Presentation] 2型糖尿病ラット膵島におけるKv2.1チャネルブロッカーによるインスリン分泌促進2009
- Author(s)
  出崎克也, 他
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-03-17
- Data Source
  KAKENHI-PROJECT-20591070
[Presentation] Ghrelin activates voltage-dependent K^+ channels by modulation of cAMP/PKA signaling in islet β-cells2009
- Author(s)
  Dezaki K., Damdindorj B., Yoshida M., Kakei M., Yada T.
- Organizer
  The 2009 International Symposium on Ghrelin
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] Ghrelin receptor antagonist enhances glucose-induced insulin release in type 2 diabetic GK rats2009
- Author(s)
  Damdindorj B., Dezaki K.,Sone H., Yaguchi T., Kakei M., Yada T.
- Organizer
  The 2009 International Symposium on Ghrelin
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] Kv2.1 channel blockers enhance glucose-induced cytosolic Ca^<2+> increases and insulin release in pancreatic β-cells of type 2 diabetic rats2009
- Author(s)
  出崎克也
- Organizer
  The XXXVI International Congress of Physiological Sciences
- Place of Presentation
  京都
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PUBLICLY-21026026
[Presentation] Kv2.1 channel blockers enhance glucose-induced cytosolic Ca^<2+> increases and insulin release in islet β-cells of type 2 diabetic rats2009
- Author(s)
  Dezaki K., Damdindorj B., Kakei M., Yada T.
- Organizer
  The 36th International Congress of Physiological Sciences (IUPS)
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] Kv2.1 channel blockers enhance glucose-induced cytosolic Ca^<2+> increases and insulin release in pancreatic β-cells of type 2 diabetic rats.2009
- Author(s)
  出崎克也
- Organizer
  The XXXVI International Congress of Physiological Sciences
- Place of Presentation
  京都
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-20591070
[Presentation] Kv2.1 channel blockers potentiate glucose-induced insulin release in islets of type2 diabetic rats2008
- Author(s)
  出崎克也, 他
- Organizer
  The 44th EASD Annual Meeting
- Place of Presentation
  Rome
- Year and Date
  2008-09-08
- Data Source
  KAKENHI-PROJECT-20591070
[Presentation] グレリンはGa_<i2>を介したKvチャネルの活性化により膵β細胞からのインスリン分泌を抑制する2008
- Author(s)
  出崎克也
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-18
- Data Source
  KAKENHI-PROJECT-18790623
[Presentation] Ghrelin suppresses insulin release via Gα_<i2>-mediated modulation of Kv channels in islet β-cells2008
- Author(s)
  出崎克也
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-18790623
[Presentation] グレリンによるβ細胞Kvチャネル活性化を介したグルコース誘発インスリン分泌抑制2008
- Author(s)
  出崎克也, Damdindorj Boldbaatar, 加計正文, 矢田俊彦
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390061
[Presentation] グレリンによるβ細胞Kvチャネル活性化を介したグルコース誘発インスリン分泌抑制2008
- Author(s)
  出崎克也, 他
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-23
- Data Source
  KAKENHI-PROJECT-19045026
[Presentation] Kv2.1 channel blockers potentiate glucose-induced insulin release in islets of type 2 diabetic rats.2008
- Author(s)
  出崎克也
- Organizer
  The 44th EASD Annual Meeting
- Place of Presentation
  Rome
- Year and Date
  2008-09-08
- Data Source
  KAKENHI-PROJECT-20591070
[Presentation] Kv2.1 channel blockers potentiate glucose-induced insulin release in islets of type 2 diabetic rats2008
- Author(s)
  出崎克也, 他
- Organizer
  The 44th EASD Annual Meeting
- Place of Presentation
  Rome
- Year and Date
  2008-09-08
- Data Source
  KAKENHI-PROJECT-19045026
[Presentation] グレリンはGαi_2を介したKvチャネルの活性化により膵β細胞からのインスリン分泌を抑制する2008
- Author(s)
  出崎克也
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-18
- Data Source
  KAKENHI-PROJECT-19045026
[Presentation] Ghrelin suppresses insulin release via Gαi_2-mediated modulation of Kv channels in islet β-cells.2008
- Author(s)
  出崎克也
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19045026
[Presentation] グレリンによるβ細胞Kvチャネル活性化を介したグルコース誘発インスリン分泌抑制2008
- Author(s)
  出崎克也
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-23
- Data Source
  KAKENHI-PROJECT-20591070
[Presentation] グレリンはGαi2を介したKvチャネルの活性化により膵β細胞インスリン分泌を抑制する2008
- Author(s)
  出崎克也
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-15081211
[Presentation] グレリンによるβ細胞Kvチャネル活性化を介したグルコース誘発インスリン分泌抑制2008
- Author(s)
  出崎克也, 他
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-23
- Data Source
  KAKENHI-PROJECT-20591070
[Presentation] Ghrelin attenuates insulin release via Gα_<i2>-mediated modulation of Kv channels and Ca^<2+> signaling in islet β-cells.2007
- Author(s)
  Dezaki K
- Organizer
  43rd EASD Annual Meeting
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-15081211
[Presentation] Ghrelin attenuates insulin release via Gα_<i2>-mediated modulation of Kv channels and Ca^<2+> signaling in islet β-cells2007
- Author(s)
  Dezaki K
- Organizer
  43rd EASD Annual Meeting
- Place of Presentation
  Amsterdam, Netherlands
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Presentation] Ghrelin attenuates glucose-induced insulin release in an autocrine/paracrine manner in pancreatic islets2007
- Author(s)
  Dezaki K
- Organizer
  42nd EASD Annual Meeting, Copenhagen
- Place of Presentation
  Malmoe,Copenhagen
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Presentation] Ghrelin attenuates insulin release via Ga_<i2>-mediated modulation of Kv channels and Ca^<2+> signaling in islet β-cells2007
- Author(s)
  出崎克也
- Organizer
  The 43rd EASD Annual Meeting
- Place of Presentation
  Amsterdam
- Data Source
  KAKENHI-PROJECT-18790623
[Presentation] グレリン遺伝子欠損マウスにおけるインスリン分泌亢進による耐糖能改善2007
- Author(s)
  出崎克也
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-15081211
[Presentation] Ghrelin attenuates insulin release via Go12-mediated modulation of Kv channels and Ca^<2+> signaling in islet β-cells.2007
- Author(s)
  Dezaki, K
- Organizer
  43rd EASD Annual Meeting
- Place of Presentation
  Amsterdam, Netherlands
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Presentation] Ghrelin attenuates glucose-induced insulin release in an autocrine/paracrine manner in pancreatic islets.2006
- Author(s)
  Dezaki, K
- Organizer
  42nd EASD Annual Meeting
- Place of Presentation
  Copenhagen, Malmoe
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390065

1. YADA Toshihiko (60166527)

# of Collaborated Projects: 9 results

# of Collaborated Products: 40 results
2. NAKATA Masanori (10305120)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
3. KAKEI Masafumi (90214270)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
4. MAEJIMA Yuko (40438669)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TORIYA Masako (90420819)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ONAKA Tatsushi (90177254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SONE Hideyuki (90398511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUJIWARA Ken (00382945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YUSAKU Iwasaki (60528420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIGETOMO Suyama (80528414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 河野大輔 (10382904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. AKITA Tenpei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. OKADA Toshiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. SATO Kaori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 高橋将文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 木村博昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 唐澤直義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 渡邊幸子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 鎌田諒

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 岡田泰伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TATSUYA Dezaki 出崎 克也

DEZAKI Katsuya 出崎 克也

Research Projects

Research Products

Co-Researchers

CD38/TRPM2を介したGLP-1のインスリン分泌促進とβ細胞保護作用メカニズムの解明Principal Investigator

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Regulation of glucose metabolism by oxytocin via insulin secretionPrincipal Investigator

Principal Investigator

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Review Section

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Molecular mechanism for highly sensitive response to peripheral hormones in hypothalamic neurons and homeostatic role

Principal Investigator

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Pathophysiological role of ghrelin in impaired GLP-1 secretion in tyte 2 diabetesPrincipal Investigator

Principal Investigator

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Glucose metabolism in ghrelin conditional KO micePrincipal Investigator

Principal Investigator

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グルコースとホルモン情報を統合する膵β細胞Kv・TRPチャネルのセンサー機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Ghrelin : its status as a pancreatic hormone, mechanisms by which it regulates insulin release and glucose metabolism, and its application for treating diabetes.

Principal Investigator

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Effective strategy to treat type 2 diabetes by blockade of ghrelin signaling in islet β-cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

TRP・Kvチャネルを介した新規グルコースセンシング-インスリン分泌連関Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

遺伝子改変技術を用いての膵島内因性グレリンによるインスリン分泌抑制機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Inputs and outputs of NPY and BDNF neurons in the hypothalamus and their implication in feeding and metabolic regulation

Principal Investigator

Project Period (FY)

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Research Institution

Regulation by endogenous ghrelin of insulin release, feeding and glucose metabolism

Principal Investigator

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Research Field

Research Institution

Novel signaling function of adipocytes

Principal Investigator

Project Period (FY)

TATSUYA Dezaki 出崎克也

DEZAKI Katsuya 出崎克也

[Book] 日本臨床第62巻増刊号92004