Toh Kazuko 藤加珠子

… Alternative Names

TOH Kazuko 藤加珠子

藤加珠子トウカズコ

藤和珠子トウカズコ

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Researcher Number	90342732
Other IDs
Affiliation (Current)	2025: 東京科学大学, 総合研究院, 特任講師 2025: 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員
Affiliation (based on the past Project Information) *help	2025: 東京科学大学, 総合研究院, 特任講師 2024: 東京医科歯科大学, 大学院医歯学総合研究科, 特任講師 2021 – 2023: 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 2017: 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 2016: 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), 川崎市産業振興財団, 研究員 … More 2015: 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), その他部局等, 研究員 2013 – 2014: 東京大学, 医学(系)研究科(研究院), 研究員 2012: 東京大学, 医学(系)研究科(研究院), 特任研究員 2004: (財)山形県産業技術振興機構, 生物ラジカル研究所, 研究員 2003: 財団法人山形県産業技術振興機構, 生物ラジカル研究所, 研究員 Less
Review Section/Research Field	Principal Investigator Tumor therapeutics / Applied pharmacology / Environmental technology/Environmental materials Except Principal Investigator Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 90110:Biomedical engineering-related / Basic Section 90120:Biomaterials-related
Keywords	Principal Investigator ドラッグデリバリーシステム / 腫瘍深部イメージング / 生体内リアルタイム蛍光共焦点顕微鏡 / 生体内リアルタイム共焦点顕微鏡 / 生体内共焦点顕微鏡 / ABC現象 / ポリエチレングリコール / 酸化防止剤 / 植物性廃棄物 / 紫外線吸収剤 … More / 機能性食品 / 腸内細菌 / 亜臨界 / 超臨界 / リグニン … More Except Principal Investigator 核酸医薬 / 核酸医薬デリバリー / ナノ医薬 / 生体内共焦点顕微鏡 / 光応答性 / 高分子ナノ医薬 / 高分子 / 薬物送達 / 炎症抑制 / 標的化 / 肺線維症 / ドラッグデリバリーシステム / アンチジーン核酸 / 生体適合性高分子 / 機能性核酸 / 脳疾患 / 核酸デリバリー / 薬物送達システム / Glioblastoma / NanoMedicine Less

Development of a Targeted Therapeutic Approach for Idiopathic Pulmonary Fibrosis Using a Drug Delivery System Loaded with Ligand-Nucleic Acid Pharmaceuticals
- Principal Investigator
  
  喜納宏昭
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
ユニットPICを起点とする次世代核酸ナノ医薬の創製と生体内バリア突破に向けた挑戦
- Principal Investigator
  
  宮田完二郎
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  The University of Tokyo
Developing Nanomedicine that targets cellular heterogeneity for Complete Glioblastoma Remission
- Principal Investigator
  
  Quader Sabina
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
Development of advanced nanomedicines for brain-targeted oligonucleotide delivery
- Principal Investigator
  
  Miyata Kanjiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  The University of Tokyo
Evaluation of tumor heterogeneity by deep tumor imaging and control of drug delivery systemPrincipal Investigator
- Principal Investigator
  
  Toh Kazuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
Elucidation and evasion of the immunogenicity induced by the repeated administration of the PEGylated nanocarrierPrincipal Investigator
- Principal Investigator
  
  TOH Kazuko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  The University of Tokyo
亜臨界及び超臨界流体を用いたリグニンの改質による未利用植物資源有効利用技術の開発Principal Investigator
- Principal Investigator
  
  藤加珠子 (藤和珠子)
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental technology/Environmental materials
- Research Institution
  Yamagata Research Institute of Technology
  Yamagata Public Corporation For the Development Of Industry, Institute Life Support Technology

All 2022 2021 2014 2013 2012 2005 2003

All Journal Article Presentation

[Journal Article] Size-tunable PEG-grafted copolymers as a polymeric nanoruler for passive targeting muscle tissues.2022
- Author(s)
  M. Naito, Y. Watanuki, K. Toh, J. Yum, B. S. Kim, K. Taniwaki, S. Ogura, H. Ishida, M. Cho, H. Chaya, K. Miyajima, K. Osada, K. Minegishi, Y. Aoki, Y. Yamasaki, K. Miyata,
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 347 Pages: 607-614
- DOI
  10.1016/j.jconrel.2022.05.030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19014, KAKENHI-PROJECT-17KK0102, KAKENHI-PROJECT-20H00658, KAKENHI-PROJECT-23K21412, KAKENHI-PROJECT-23K21857
[Journal Article] ポリイオンコンプレックスによるmRNAデリバリーに向けたカチオン性ポリペプチド設計2022
- Author(s)
  内藤瑞、宮田完二郎
- Journal Title
  
  Drug Delivery System
  
  Volume: 37 Pages: 221-228
- Open Access
- Data Source
  KAKENHI-PROJECT-20H00658
[Journal Article] Dynamic Stabilization of Unit Polyion Complexes Incorporating Small Interfering RNA by Fine-Tuning of Cationic Block Length in Two-Branched Poly(ethylene glycol)-<i>b</i>-poly(<scp>l</scp>-lysine)2021
- Author(s)
  Chaya Hiroyuki、Naito Mitsuru、Cho Masaru、Toh Kazuko、Hayashi Kotaro、Fukushima Shigeto、Yamasaki Yuichi、Kataoka Kazunori、Miyata Kanjiro
- Journal Title
  
  Biomacromolecules
  
  Volume: 23 Issue: 1 Pages: 388-397
- DOI
  10.1021/acs.biomac.1c01344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00658
[Journal Article] Multicompartment Micelles with Adjustable Poly(ethylene glycol) Shell for Efficient in Vivo Photodynamic Therapy2014
- Author(s)
  Christopher V. Synatschke, Takahiro Nomoto, Horacio Cabral, Melanie Förtsch, Kazuko Toh, Yu Matsumoto, Kozo Miyazaki, Andreas Hanisch, Felix H. Schacher, Akihiro Kishimura, Nobuhiro Nishiyama, Axel H. E. Müller, and Kazunori Kataoka
- Journal Title
  
  ACS NANO
  
  Volume: 8(2) Pages: 1161-1172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790530
[Journal Article] Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer2014
- Author(s)
  Hyun Jin Kim, Takehiko Ishii, Meng Zheng, Sumiyo Watanabe, Kazuko Toh, Yu Matsumoto, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
- Journal Title
  
  Drug Delivery and Translational Research
  
  Volume: 4 Issue: 1 Pages: 50-60
- DOI
  10.1007/s13346-013-0175-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13F03349, KAKENHI-PROJECT-23390009, KAKENHI-PROJECT-23790043, KAKENHI-PROJECT-24659411, KAKENHI-PROJECT-24790530, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-25282141, KAKENHI-PROJECT-26670738
[Journal Article] Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors2014
- Author(s)
  Z. Ge, Q. Chen, K. Osada, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka
- Journal Title
  
  Biomaterials
  
  Volume: 35 Issue: 10 Pages: 3416-3426
- DOI
  10.1016/j.biomaterials.2013.12.086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790043, KAKENHI-PROJECT-23790433, KAKENHI-PROJECT-24300170, KAKENHI-PROJECT-24790530, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-25882011, KAKENHI-PROJECT-26293119, KAKENHI-PROJECT-26670738
[Journal Article] Tethered PEG Crowdedness Determining Shape and Blood Circulation Profile of Polyplex Micelle Gene Carriers2013
- Author(s)
  Theofilus A. Tockary, Kensuke Osada, Qixian Chen, Kaori Machitani, Anjaneyulu Dirisala, Satoshi Uchida, Takahiro Nomoto, Kazuko Toh, Yu Matsumoto, Keiji Itaka, Koji Nitta, Kuniaki Nagayama, and Kazunori Kataoka
- Journal Title
  
  Macromolecules
  
  Volume: 46 Issue: 16 Pages: 6585-6592
- DOI
  10.1021/ma401093z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300170, KAKENHI-PROJECT-24790530, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-25882011
[Journal Article] Evaluation of the Dynamics of Drug Delivery Systems (DDS) Using Intravital Real-Time Confocal Laser Scanning Microscopy2012
- Author(s)
  野本貴大、松本　有、藤　加珠子、R. James Christie、宮田完二郎、大庭　誠、Horacio Cabral、村上真美、福島重人、西山伸宏、片岡一則
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 132 Issue: 12 Pages: 1347-1354
- DOI
  10.1248/yakushi.12-00234-1
- NAID
  130002489530
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2012-12-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790530
[Journal Article] Evaluation of the Ability of Aqueous Lignin-Carbohydrate Complex Extracted from Botanical Waste to Scavenge Reactive Oxygen Species by Using Electron spin Resonance Method2005
- Author(s)
  藤加珠子
- Journal Title
  
  Wood and Fiber Science 37(2)(印刷中)
- Data Source
  KAKENHI-PROJECT-15710070
[Journal Article] 植物性廃棄物由来リグニンの抽出と機能性評価2003
- Author(s)
  藤加珠子
- Journal Title
  
  平成15年度生物ラジカル研究年報
  
  Pages: 13-13
- Data Source
  KAKENHI-PROJECT-15710070
[Presentation] 1分子核酸医薬内包ユニットポリイオンコンプレックスの血中滞留性向上を指向したブロック共重合体のカチオン鎖長設計2022
- Author(s)
  内藤瑞, 茶谷洋行, 張賢, 藤加珠子, 林光太朗, 福島重人, 山﨑裕一, 片岡一則, 宮田完二郎
- Organizer
  第71回高分子学会年次大会
- Data Source
  KAKENHI-PROJECT-20H00658
[Presentation] リガンド導入数を制御可能なグラフトコポリマーの合成および細胞取り込み挙動の評価2022
- Author(s)
  張賢, 木下動, 内藤瑞, 綿貫裕介, ヨムジョンミン, キムボブス, 山﨑裕一, 宮田完二郎
- Organizer
  第71回高分子学会年次大会
- Data Source
  KAKENHI-PROJECT-20H00658
[Presentation] 血中滞留性向上を目指した1分子siRNA内包ユニットポリイオンコンプレックスの設計2022
- Author(s)
  内藤瑞, 茶谷洋行, 張賢, 藤加珠子, 林光太朗, 福島重人, 山崎裕一, 片岡一則, 宮田完二郎
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-20H00658
[Presentation] 血中滞留性向上を目指した１分子siRNA内包ユニットポリイオンコンプレックスの設計2022
- Author(s)
  内藤瑞, 茶谷洋行, 張賢, 藤加珠子, 林光太朗, 福島重人, 山崎裕一, 片岡一則, 宮田完二郎
- Organizer
  第27回創剤フォーラム若手研究会
- Data Source
  KAKENHI-PROJECT-20H00658
[Presentation] 1分子核酸内包ユニットポリイオンコンプレックスの血中滞留性向上を指向した分子設計2022
- Author(s)
  内藤瑞, 茶谷洋行, 張賢, 藤加珠子, 林光太朗, 福島重人, 片岡一則, 宮田完二郎
- Organizer
  第71回高分子討論会
- Data Source
  KAKENHI-PROJECT-20H00658
[Presentation] Prolonged blood circulation of siRNA-loaded ultrasmall polymeric nanocarriers by fine-tuning of oligonucleotide structures2021
- Author(s)
  H. Chaya, M. Naito, K. Toh, B. S. Kim, K. Hayashi, S. Fukushima, K. Kataoka, K. Miyata
- Organizer
  The 48th Annual Meeting of the Controlled Release Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00658
[Presentation] 血中動態の改善を指向した化学修飾核酸siRNA封入ユニットポリイオンコンプレックスの構築2021
- Author(s)
  茶谷洋行, 内藤瑞, 藤加珠子, 林光太朗, 福島重人, 片岡一則, 宮田完二郎
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00658
[Presentation] 1分子核酸内包キャリアの血中滞留性向上を指向したブロック共重合体の精密設計2021
- Author(s)
  茶谷洋行, 内藤瑞, 張賢, 藤加珠子, キムボブス, キムヒョンジン, 林光太朗, 福島重人, 片岡一則, 宮田完二郎
- Organizer
  第70回高分子討論会
- Data Source
  KAKENHI-PROJECT-20H00658
[Presentation] Intravital confocal microscopy assay for the evaluation of antioxidant capacity2014
- Author(s)
  Yu Matsumoto, Kazuko Toh, Kazunori Kataoka and Tatsuya Yamasoba
- Organizer
  37th ARO MidWinter Meeting
- Place of Presentation
  San Diego, California, USA
- Data Source
  KAKENHI-PROJECT-24790530
[Presentation] Intravital Monitoring of Intact siRNA Using Fluorescence Resonance Energy Transfer2013
- Author(s)
  Kazuko Toh, Takahiro Nomoto, Yu Matsumoto, Sumiyo Watanabe, Shigeto Fukushima, Hiroyuki Chaya, R. James Christie, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka
- Organizer
  40th annual meeting & exposition of the Controlled Release Society
- Place of Presentation
  Honolulu, Hawaii, U. S. A.
- Data Source
  KAKENHI-PROJECT-24790530
[Presentation] Förster Resonance Energy Transferと生体内顕微鏡を用いたintact siRNAの定量的評価法の開発2013
- Author(s)
  藤　加珠子, 野本　貴大, 松本　有, 渡邉　秀美代, 福島　重人, 茶谷　洋行, R. James Christie, 宮田　完二郎, 西山　伸宏, 片岡　一則
- Organizer
  第35回日本バイオマテリアル学会大会
- Place of Presentation
  東京都江戸川区船堀4-1-1 タワーホール船堀
- Data Source
  KAKENHI-PROJECT-24790530

1. Miyata Kanjiro (50436523)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. 劉学瑩 (30777470)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Quader Sabina (90749699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 谷口陽祐 (00452714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 林光太朗 (00780660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. 喜納宏昭 (70283067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Cabral Horacio (10533911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Mohamed Aziz・Awaad・Aziz (50978286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 野本貴大 (00734732)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OSADA Kensuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. ITAKA Keiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. MATSUMOTO Yu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. ZHENG Meng

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
14. 片岡一則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Toh Kazuko 藤 加珠子

TOH Kazuko 藤 加珠子

藤 加珠子 トウ カズコ

藤 和珠子 トウ カズコ

Research Projects

Research Products

Co-Researchers

Development of a Targeted Therapeutic Approach for Idiopathic Pulmonary Fibrosis Using a Drug Delivery System Loaded with Ligand-Nucleic Acid Pharmaceuticals

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ユニットPICを起点とする次世代核酸ナノ医薬の創製と生体内バリア突破に向けた挑戦

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Developing Nanomedicine that targets cellular heterogeneity for Complete Glioblastoma Remission

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of advanced nanomedicines for brain-targeted oligonucleotide delivery

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of tumor heterogeneity by deep tumor imaging and control of drug delivery systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation and evasion of the immunogenicity induced by the repeated administration of the PEGylated nanocarrierPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

亜臨界及び超臨界流体を用いたリグニンの改質による未利用植物資源有効利用技術の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Size-tunable PEG-grafted copolymers as a polymeric nanoruler for passive targeting muscle tissues.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ポリイオンコンプレックスによるmRNAデリバリーに向けたカチオン性ポリペプチド設計2022

Author(s)

Journal Title

Data Source

[Journal Article] Dynamic Stabilization of Unit Polyion Complexes Incorporating Small Interfering RNA by Fine-Tuning of Cationic Block Length in Two-Branched Poly(ethylene glycol)-<i>b</i>-poly(<scp>l</scp>-lysine)2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multicompartment Micelles with Adjustable Poly(ethylene glycol) Shell for Efficient in Vivo Photodynamic Therapy2014

Author(s)

Journal Title

Data Source

[Journal Article] Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tethered PEG Crowdedness Determining Shape and Blood Circulation Profile of Polyplex Micelle Gene Carriers2013

Author(s)

Journal Title

Toh Kazuko 藤加珠子

TOH Kazuko 藤加珠子

藤加珠子トウカズコ

藤和珠子トウカズコ