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Makino Yuichi  牧野 雄一

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MAKINO Yuichi  牧野 雄一

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Researcher Number 90345033
Other IDs
External Links
Affiliation (Current) 2025: 旭川医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2019 – 2023: 旭川医科大学, 医学部, 教授
2011 – 2018: 旭川医科大学, 医学部, 准教授
2007 – 2010: Asahikawa Medical College, 医学部, 講師
2006: Asahikawa Medical College, School of Medicine, Assistant Professor, 医学部, 特任講師
2004 – 2005: 東京大学, 医科学研究所, 助手
2002 – 2003: 東京大学, 医科学研究所, 教務職員
Review Section/Research Field
Principal Investigator
膠原病・アレルギー・感染症内科学 / Biological Sciences / Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology
Except Principal Investigator
Biological Sciences / Orthopaedic surgery / Metabolomics
Keywords
Principal Investigator
低酸素 / HIF-1 / 肺高血圧症 / IPAS / 低酸素誘導性転写因子 / HIF-3α / 膠原病 / SiRNA / 血管新生 / 転写因子 … More / 低酸素応答性転写因子 / ゲノム編集 / 低酸素応答 / 標的遺伝子 / SNP / 一塩基多型 / ChREBP / マクロファージ / mRNAスプライシング / HIF-1α / T細胞 / 遺伝子改変マウス / 肺血管リモデリング / 出生後死亡 / KOマウス / 遺伝子多型 / 肺高血圧 / 遺伝子破壊動物 / ゲノム編集法 / 遺伝子転写制御 / Adrenomedullin / Si RNA / protein degradation / T cell / Hypoxia / アドレノメジュリン / 蛋白分解 / HIF-3a / エンドセリン1 / HIF / エンドセリン1 / 単核球 / 単球 / 炎症 / 関節炎 / 炎症細胞 / VEGF / 選択的スプライシング / マイクロアレイ / アポトーシス / 活性化細胞死 / T細胞受容体 … More
Except Principal Investigator
発現制御 / シグナル伝達 / 核酸 / スプライシング / 転写因子 / 臨床 / 免疫学 / 転写 / バイオテクノロジー / ゲノム / 血管新生 / 遺伝子発現異常 / ChREBP / 高グルコース / 糸球体 / メサンギウム細胞 / 糖尿病性腎症 / 糖尿病 / NF-κB / 滑膜炎 / 関節リウマチ / リウマチ病学 / 癌 / 遺伝子発現 / 低酸素 / RNA / 悪性腫瘍 / 酸素センシング / 共役因子 Less
  • Research Projects

    (17 results)
  • Research Products

    (78 results)
  • Co-Researchers

    (9 People)
  •  Study on molecular mechanism underlying pulmonary hypertension and dysregulation of pulmonary vascular remodeling mediated by hypoxia-inducible transcription factorPrincipal Investigator

    • Principal Investigator
      牧野 雄一
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      Asahikawa Medical College
  •  Gene dysregulation by single nucleotide polymorphism of hypoxia-inducible transcription factor in molecular pathology of pulmonary hypertensionPrincipal Investigator

    • Principal Investigator
      Makino Yuichi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      Asahikawa Medical College
  •  Molecular pathology for IPAS/HIF-3a gene SNP-mediated pulmonary hypertension in connective tissue diseasePrincipal Investigator

    • Principal Investigator
      Makino Yuichi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Asahikawa Medical College
  •  Role of IPAS/HIF-3alpha-mediated signals in the pathophysiology of pulmonary hypertension associated with connective tissue diseasePrincipal Investigator

    • Principal Investigator
      Makino Yuichi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Asahikawa Medical College
  •  Elucidation of the regulatory mechanism for glucose-mediated pathogenic gene expression in diabetic nephropathy and its therapeutic application

    • Principal Investigator
      Haneda Masakazu
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Asahikawa Medical College
  •  Role of hypoxia-inducible transcription factors in regulation of immune response and its therapeutic applicationPrincipal Investigator

    • Principal Investigator
      MAKINO Yuichi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Asahikawa Medical College
  •  マイクロRNAによるNF-κB制御を介した関節リウマチ治療戦略に関する研究

    • Principal Investigator
      平野 史倫
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Asahikawa Medical College
  •  Mechanism of regulation of immune response by hypoxia-inducible factors and its therapeutic application to inflammatory diseasesPrincipal Investigator

    • Principal Investigator
      MAKINO Yuichi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Asahikawa Medical College
  •  Strategise for treatment of rheumatoid synovitis on the focus of IκBβ2 expression.

    • Principal Investigator
      HIRANO Fuminori
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Asahikawa Medical College
  •  低酸素シグナル抑制分子IPASの発現制御法の開発とがん治療への応用Principal Investigator

    • Principal Investigator
      牧野 雄一
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Asahikawa Medical College
  •  HIF-1拮抗分子IPASの発現制御機構の解明と抗血管新生療法開発への応用Principal Investigator

    • Principal Investigator
      牧野 雄一
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Development of a novel therapy targeting the hypoxia response system in the immune cells for inflammatory diseases.Principal Investigator

    • Principal Investigator
      MAKINO Yuichi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Asahikawa Medical College
      The University of Tokyo
  •  低酸素誘導性転写因子群を標的とする新規抗血管新生療法開発に関する研究Principal Investigator

    • Principal Investigator
      牧野 雄一
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  HIF-1抑制分子IPAS遺伝子の発現調節機構の解明

    • Principal Investigator
      田中 廣壽
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  低酸素応答性選択的スプライシング機構の解明と生体機能調節

    • Principal Investigator
      田中 広寿 (田中 廣壽)
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  低酸素シグナルによるリンパ球機能制御機構の解明Principal Investigator

    • Principal Investigator
      牧野 雄一
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      The University of Tokyo
  •  低酸素誘導性転写因子に拮抗する新規蛋白IPASのがん増殖、進展における役割

    • Principal Investigator
      田中 廣壽
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo

All 2019 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005 2004 Other

All Journal Article Presentation Book

  • [Book] 腎症のトピックスHypoxia-inducible factor-1 (HIF-1) ヴィジュアル糖尿病臨床のすべて『糖尿病腎症のすべて』2012

    • Author(s)
      牧野雄一、羽田勝計
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Book] Hypoxia-inducible factor-1 (HIF-1)の発現制御 からだと酸素の事典2009

    • Author(s)
      牧野雄一
    • Publisher
      朝倉書店
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Journal Article] Role of IGFBP7 in Diabetic Nephropathy: TGF-β1 Induces IGFBP7 via Smad2/4 in Human Renal Proximal Tubular Epithelial Cells.2016

    • Author(s)
      Takiyama Y, Watanabe J, Honjyo J, Makino Y, Fujita Y, Tateno M, Haneda M.
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 3 Pages: 1-20

    • DOI

      10.1371/journal.pone.0150897

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09372, KAKENHI-PROJECT-24390229
  • [Journal Article] High glucose induces platelet-derived growth factor-C via carbohydrate response element-binding protein in glomerular mesangial cells.2016

    • Author(s)
      Kitsunai H, Makino Y, Sakagami H, Mizumoto K, Yanagimachi T, Atageldiyeva K, Takeda Y, Fujita Y, Abiko A, Takiyama Y, Haneda M.
    • Journal Title

      Physiol Rep

      Volume: 4 Issue: 6 Pages: 1-13

    • DOI

      10.14814/phy2.12730

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09372, KAKENHI-PROJECT-15K09373, KAKENHI-PROJECT-24390229
  • [Journal Article] Loss of HIF-1αimpairs GLUT4 translocation and glucose uptake by the skeletal muscle cells2014

    • Author(s)
      Sakagami H, Makino Y, Mizumoto K, Isoe T, Takeda Y, Watanabe J, Fujita Y, Takiyama Y, Abiko A, Haneda M
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 306

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Journal Article] Loss of HIF-1α impairs GLUT4 translocation and glucose uptake by the skeletal muscle cells.2014

    • Author(s)
      Sakagami H, Makino Y, Mizumoto K, Isoe T, Takeda Y, Watanabe J, Fujita Y, Takiyama Y, Abiko A, Haneda M.
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: .

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390229
  • [Journal Article] Loss of HIF-1α impairs GLUT4 translocation and glucose uptake by the skeletal muscle cells.2014

    • Author(s)
      Sakagami H, Makino Y, Mizumoto K, Isoe T, Takeda Y, Watanabe J, Fujita Y, Takiyama Y, Abiko A, Haneda M.
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 306 Issue: 9 Pages: E1065-E1076

    • DOI

      10.1152/ajpendo.00597.2012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Journal Article] Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis2013

    • Author(s)
      Tamaki Y, Nakade Y, Yamauchi T, Makino Y, Yokohama S, Okada M, Aso K, Kanamori H, Ohashi T, Sato K, Nakao H, Haneda M, Yoneda M
    • Journal Title

      J Gastroenterol

      Volume: 48 Pages: 491-503

    • NAID

      10031169224

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Journal Article] The Krüppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms2013

    • Author(s)
      Khalesi E, Nakamura H, Lee KL, Putra AC, Fukazawa T, Kawahara Y, Makino Y, Poellinger L, Yuge L, Tanimoto K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 441 Pages: 499-506

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Journal Article] The Krüppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms.2013

    • Author(s)
      Khalesi E, Nakamura H, Leong Lee K, Chandra Putra A, Fukazawa T, Kawahara Y, Makino Y, Poellinger L, Yuge L, Tanimoto K.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 441 Issue: 2 Pages: 499-506

    • DOI

      10.1016/j.bbrc.2013.10.083

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591453, KAKENHI-PROJECT-23592766
  • [Journal Article] 心腎連関:腎虚血の病態における意義2012

    • Author(s)
      牧野雄一、羽田勝計
    • Journal Title

      月刊糖尿病

      Volume: 4(2) Pages: 75-83

    • Data Source
      KAKENHI-PROJECT-23591453
  • [Journal Article] Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice.2012

    • Author(s)
      Takeda Y, Fujita Y, Honjo J, Yanagimachi T, Sakagami H, Takiyama Y, Makino Y, Abiko A, Kieffer TJ, Haneda M.
    • Journal Title

      Diabetologia

      Volume: 55 Issue: 2 Pages: 404-12

    • DOI

      10.1007/s00125-011-2365-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591291, KAKENHI-PROJECT-24390229
  • [Journal Article] Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice2012

    • Author(s)
      Takeda Y, Fujita Y, Honjo J, Yanagimachi T, Sakagami H, Takiyama Y, Makino Y, Abiko A, Kieffer TJ, Haneda M
    • Journal Title

      Diabetologia

      Volume: 55 Pages: 404-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Journal Article] 糖尿病性腎症の現況と今後の展望 高血糖が関わる新たな分子機構2012

    • Author(s)
      牧野雄一、羽田勝計
    • Journal Title

      Diabetes Frontier

      Volume: 23 (5) Pages: 535-539

    • Data Source
      KAKENHI-PROJECT-23591453
  • [Journal Article] 骨格筋のインスリン感受性制御における転写因子HIF-1αの役割の解明とインスリン抵抗性解除法開発への応用2012

    • Author(s)
      牧野雄一
    • Journal Title

      Therapeutic Research

      Volume: 33 (6) Pages: 843-847

    • Data Source
      KAKENHI-PROJECT-23591453
  • [Journal Article] 糖尿病性腎症の成因と病態~新たな展開~III.HIF-1α2011

    • Author(s)
      牧野雄一、磯江つばさ、羽田勝計
    • Journal Title

      日本腎臓学会誌

      Volume: 53(7) Pages: 1006-1009

    • Data Source
      KAKENHI-PROJECT-23591453
  • [Journal Article] シンポジウム1:糖尿病腎症の新展開腎症発症•進展と転写因子2011

    • Author(s)
      牧野雄一、磯江つばさ、羽田勝計
    • Journal Title

      日本糖尿病合併症

      Volume: 25(1) Pages: 36-39

    • Data Source
      KAKENHI-PROJECT-23591453
  • [Journal Article] Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin : A Possible Role of HIF-1α Expression and Oxygen Metabolism2011

    • Author(s)
      Takiyama Y, Harumi T, Watanabe J, Fujita Y, Honjo J, Shimizu N, Makino Y, Haneda M
    • Journal Title

      Diabetes 60

      Pages: 981-992

    • NAID

      120004606769

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Journal Article] Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Met formin : A Possible Role of Hypoxia Inducible Factor-1 {alpha} Expression and Oxygen Metabolism.2011

    • Author(s)
      Takiyama Y, Harumi T, Watanabe J, Fujita Y, Honjo J, Shimizu N, Makino Y, Haneda M.
    • Journal Title

      Diabetes

      Volume: 60 Pages: 981-992

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Journal Article] High glucose activates HIF-1-mediated signal transduction in glomer ular mesangial cells through a carbohydrate response element binding protein.2010

    • Author(s)
      lsoe T, Makino_Y, Mizumoto K, Sakagami H, Fulita Y, Honjo J,Takiyama Y, ltoh H, Hane da M
    • Journal Title

      Kidney Int

      Volume: 78 Pages: 48-59

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Journal Article] High glucose activates HIF-1-mediated signal transduction via carbohydrate response element binding protein in glomerular mesangial cells2010

    • Author(s)
      Isoe T, Makino Y, Mizumoto K, Sakagami H, Fujita Y, Honjo J, Takiyama Y, Itoh H, Haneda M.
    • Journal Title

      Kideny Int. 78

      Pages: 48-59

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Journal Article] 炎症制御における低酸素誘導性転写因子群の役割2009

    • Author(s)
      牧野雄一、羽田勝計
    • Journal Title

      外科と代謝・栄養 44

      Pages: 225-227

    • NAID

      10026699876

    • Data Source
      KAKENHI-PROJECT-20591181
  • [Journal Article] 転写因子と糖尿病性腎症2009

    • Author(s)
      牧野雄一、羽田勝計
    • Journal Title

      月刊糖尿病 1

      Pages: 50-58

    • Data Source
      KAKENHI-PROJECT-20591181
  • [Journal Article] 高血糖による遺伝子発現異常と腎障害2009

    • Author(s)
      牧野雄一、磯江つばさ、羽田勝計
    • Journal Title

      アンチ・エイジング医学-日本抗加齢医学会雑誌 5

      Pages: 196-200

    • Data Source
      KAKENHI-PROJECT-20591181
  • [Journal Article] レドックスシグナルと酸化ストレス応答の分子機構を探る2008

    • Author(s)
      牧野雄一、岡本健作、羽田勝計
    • Journal Title

      分子消化器病 5

      Pages: 6-11

    • Data Source
      KAKENHI-PROJECT-20591181
  • [Journal Article] Abnormal heart development and lung remodeling in mice lacking a HIF-related bHLH-PAS protein NEPAS2008

    • Author(s)
      Toshiharu Yamashita, Osamu Ohneda, Masumi Nagano, Motoyuki Iemitsu, Yuichi Makino, Hirotoshi Tanaka, Takashi Miyauchi Katsutoshi Goto, Kuniko Ohneda, Yoshiaki Fujii-Kuriyama, Lorenz Poellinger, Masayuki Yamamoto
    • Journal Title

      Mol.Cell.Biol. 28

      Pages: 1285-1297

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Journal Article] 低酸素による炎症・免疫制御-HIF-1と炎症・免疫2008

    • Author(s)
      牧野雄一羽田勝計
    • Journal Title

      医学のあゆみ 225

      Pages: 7203-7207

    • Data Source
      KAKENHI-PROJECT-20591181
  • [Journal Article] Transcriptional upregulation of IPAS gene expression by HIF-1 : a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells2007

    • Author(s)
      Yuichi Makino, Rie Uenishi, Kensaku Okamoto, Tsubasa Isoe, Osamu Hosono, Hirotoshi Tanaka, Arvydas Kanopka, Lorenz Poellinger, Masakazu Haneda, Chikao Morimoto
    • Journal Title

      J.Biol.Chem. 282

      Pages: 14073-14082

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591035
  • [Journal Article] Transcriptional upregulation of IPAS gene expression by HIF-1 : A negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells.2007

    • Author(s)
      Yuichi Makino
    • Journal Title

      J. Biol. Chem

    • Data Source
      KAKENHI-PROJECT-17591035
  • [Journal Article] Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1) : a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells2007

    • Author(s)
      Makino Y, Uenishi R, Okamoto K, Isoe T, Hosono O, Tanaka H, Kanopka A, Poellinger L, Haneda M, Morimoto C.
    • Journal Title

      J Biol Chem 282(19)

      Pages: 14073-14082

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591749
  • [Journal Article] Transcriptional upregulation of IPAS gene expression by HIF-1 : A negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells.2007

    • Author(s)
      Yuichi Makino
    • Journal Title

      J.Biol.Chem

    • Data Source
      KAKENHI-PROJECT-18015012
  • [Journal Article] Transcriptional upregulation of IPAS gene expression by HIF-1 : A negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells.2007

    • Author(s)
      Yuichi Makino
    • Journal Title

      J. Biol. Chem 282

      Pages: 14073-14082

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591035
  • [Journal Article] Transcriptional upregulation of LAPS gene expression by HIF-1: a negate-ve feedback regulatory circuit in HIF-1-mediated signaling in hypoxic c-ells2007

    • Author(s)
      Yuichi Makino
    • Journal Title

      J. Biol. Chem. 282(19)

      Pages: 14073-14073

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18015012
  • [Journal Article] Physiological Activation of Hypoxia Inducible Factor - 1 in Human Skeletal Muscle2005

    • Author(s)
      Helene Ameln, Thomas Gustafsson, Carl Johan Sundberg, Kensaku Okamoto, Lorenz Poellinger, Eva Jansson, Yuichi Makino
    • Journal Title

      FASEB.J (in press)

    • Data Source
      KAKENHI-PROJECT-15790509
  • [Journal Article] Physiological Activation of Hypoxia Inducible Factor - 1 in Human Skeletal Muscle2005

    • Author(s)
      Helene Ameln, Thomas Gustafsson, Carl Johan Sundberg, Kensaku Okamoto, Lorenz Poellinger, Eva Jansson, Yuichi Makino
    • Journal Title

      FASEB.J (in press)

    • Data Source
      KAKENHI-PROJECT-16023221
  • [Journal Article] TCR-engagement increases HIF-1α protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells2005

    • Author(s)
      Hiroshi Nakamura, Yuichi Makino, Kensaku Okamoto, et al.
    • Journal Title

      J.Immunol. (印刷中)

    • Data Source
      KAKENHI-PROJECT-15030212
  • [Journal Article] 低酸素シグナルによる末梢でのT細胞の制御2005

    • Author(s)
      牧野雄一, 森本幾夫, 田中廣壽
    • Journal Title

      臨床免疫 43巻、1号

      Pages: 92-96

    • NAID

      40006610625

    • Data Source
      KAKENHI-PROJECT-15790509
  • [Journal Article] IPASによる低酸素応答性遺伝子発現の制御2004

    • Author(s)
      牧野雄一
    • Journal Title

      臨床免疫 41巻、4号

      Pages: 472-476

    • NAID

      40006192444

    • Data Source
      KAKENHI-PROJECT-16023221
  • [Presentation] 肺高血圧症に関連するHIF-3α遺伝子一塩基多型とエンドセリン遺伝子制御異常2019

    • Author(s)
      牧野雄一
    • Organizer
      第4回生活習慣病とがんの代謝栄養メカニズム研究会
    • Data Source
      KAKENHI-PROJECT-17K09964
  • [Presentation] 膠原病性肺高血圧患者に見いだされたHypoxia-inducible factor-3a遺伝子一塩基多型によるエンドセリン遺伝子発現制御異常2016

    • Author(s)
      水元克俊、高取恭平、高取清香、吉本良太、江口耕平、藤代大介、児玉暁、小林厚志、岡本健作、飯田貴久、川口鎮司、牧野雄一
    • Organizer
      第60回日本リウマチ学会総会•学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-04-21
    • Data Source
      KAKENHI-PROJECT-26461456
  • [Presentation] 膠原病性肺高血圧症における Hypoxia-inducible factor-3α遺伝子 一塩基多型とエンドセリン1遺伝子発現制異常2016

    • Author(s)
      牧野雄一、川口鎮司、水元克俊
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26461456
  • [Presentation] High glucose upregulates membrane-bound transcription factor peptidase site1 through carbohydrate response element binding protein in mesangial cells2015

    • Author(s)
      tageldiyeva K, Makino Y, Kitsunai H, Mizumoto K, Yanagimachi T, Fujita Y, Abiko A, Takiyama Y,and Haneda M
    • Organizer
      14th Korea-Japan Diabetic Nephropathy Symposium
    • Place of Presentation
      Seoul, KOrea
    • Year and Date
      2015-10-30
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24390229
  • [Presentation] Pulmonary arterial hypertension-associated single nucleotide polymorphisms of hypoxia-inducible factor-3α gene cause constitutive activation of the endothelin-1 gene promoter.2015

    • Author(s)
      Mizumoto K, Takatori K, Takatori S, Yoshimoto R, Eguchi K, Fujishiro D, Kodama S, Kobayashi A, Okamoto K, Kawaguchi Y,Haneda M, and Makino Y
    • Organizer
      American College of Rheumatology Annual Meeting,2015
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2015-11-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461456
  • [Presentation] igh glucose induces membrane-bound transcription factor peptidase site1 via carbohydrate response element binding protein to modulate ER stress in mesangial cells2015

    • Author(s)
      Makino Y, Kitsunai H, Atageldiyeva K, Mizumoto K, Yanagimachi T, Fujita Y, Abiko A, Takiyama Y,and Haneda M
    • Organizer
      51th Annual Meeting of the European Association for the Study of Diabetes
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2015-09-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24390229
  • [Presentation] グルコース応答性転写因子ChREBPが誘導するメサンギウム細胞における遺伝子発現の変化2013

    • Author(s)
      牧野雄一、橘内博哉、坂上英充、柳町剛司、藤田征弘、安孫子亜津子、滝山由美、羽田勝計
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-24390229
  • [Presentation] グルコース応答性転写因子ChREBPが誘導するメサンギウム細胞における遺伝子発現の変化2013

    • Author(s)
      牧野雄一、橘内博哉、坂上英充、柳町剛司、藤田征弘、安孫子亜津子、滝山由美、羽田勝計
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Presentation] グルコース応答性転写因子ChREBPはメサンギウム細胞においてplatelet-derived growth factor(PDGF)-C発現を誘導する2013

    • Author(s)
      橘内博哉,牧野雄一,坂上英充,水元克俊、柳町剛司,竹田安孝、藤田征弘,安孫子亜津子,滝山由美,羽田勝計
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本市
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Presentation] グルコース応答性転写因子ChREBPはメサンギウム細胞においてplatelet-derived growth factor(PDGF)-C発現を誘導する2013

    • Author(s)
      橘内 博哉, 牧野 雄一, 坂上 英充, 水元克俊、柳町 剛司, 竹田安孝、藤田 征弘, 安孫子 亜津子, 滝山 由美, 羽田 勝計
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本市
    • Data Source
      KAKENHI-PROJECT-24390229
  • [Presentation] 糖尿病性腎症の成因ー転写因子を中心にー2013

    • Author(s)
      牧野雄一、羽田勝計
    • Organizer
      第47回糖尿学の進歩 シンポジウム4:糖尿病性腎症の進歩—最近の進歩
    • Place of Presentation
      四日市市
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Presentation] 骨格筋のインスリン感受性制御における転写因子HIF-1αの役割の解明とインスリン抵抗性解除法開発への応用2012

    • Author(s)
      牧野雄一
    • Organizer
      第8回メタボリックシンドローム研究会
    • Place of Presentation
      東京都
    • Year and Date
      2012-01-21
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Presentation] HIF-1αis a determinant of insulin-dependent glucose uptake by Skeletal Muscle Cells2012

    • Author(s)
      Yuichi Makino, Hidemitsu Sakagami, Shuhei Tomita, Katsutoshi Mizumoto, Kensaku Okamoto, Hiroya Kitsunai, Yukihiro Fujita, Yumi Takiyama, and Masakazu Haneda
    • Organizer
      Keystone Symposia, Advances in Hypoxic Signaling : From Bench to Bedside
    • Place of Presentation
      Banff, Canada
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Presentation] Critical involvement of HIF-1αin regulation of insulin-dependent GLUT4 translocation and glucose uptake by skeletal muscle cells2012

    • Author(s)
      Yuichi Makino, Hidemitsu Sakagami, Hiroya Kitsunai, Shuhei Tomita, Kensaku Okamoto, Yukihiro Fujita, Yumi Takiyama, and Masakazu Haneda
    • Organizer
      The 33^<rd> Naito Conference on Oxygen Biology : Hypoxia, Oxidative Stress and Diseases
    • Place of Presentation
      Sapporo, Japan
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Presentation] Regulation of IPAS expression; a model for hypoxia-inducible alternative splicing2012

    • Author(s)
      Yuichi Makino
    • Organizer
      Singapore SGP seminar
    • Place of Presentation
      Singapore
    • Year and Date
      2012-08-17
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Presentation] グルコース応答性転写因子ChREBPがメサンギウム細胞において制御する遺伝子群の探索2012

    • Author(s)
      橘内博哉,牧野雄一,坂上英充,柳町剛司,藤田征弘,安孫子亜津子,滝山由美,羽田勝計
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Presentation] High glucose induces platelet derived growth factor C (PDGF-C) expression in glomerular mesangial cells via a glucose responsive transcription factor, carbohydrate response element binding protein (ChREBP)2012

    • Author(s)
      Hiroya Kitsunai, Yuichi Makino, Hidemitsu Sakagami, Katsutoshi Mizumoto, Tsuyoshi Yanagimachi, Yasutaka Takeda, Yukihiro Fujita, Atsuko Abiko, Yumi Takiyama, and Masakazu Haneda
    • Organizer
      72^<th > Scientific Sessions, American Diabetes Association
    • Place of Presentation
      Philadelphia, USA
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Presentation] 骨格筋のインスリン感受性制御におけるHIF-1αの役割2011

    • Author(s)
      坂上英充、牧野雄一、水元克俊、冨田修平、羽田勝計
    • Organizer
      第8回がんとハイポキシア研究会
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Presentation] Knockdown of HIF-1αabrogates insulin-stimulated glucose uptake in skeletal muscle cells2011

    • Author(s)
      Hidemitsu Sakagami, Yuichi Makino, Hiroya Kitsunai, Katsutoshi Mizumoto, Yukihiro Fujita, Yumi Takiyama, Atsuko Abiko, Masakazu Haneda
    • Organizer
      71^<th > Scientific Sessions, American Diabetes Association
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Presentation] 骨格筋のインスリン感受性制御における転写因子HIF-1αの役割2011

    • Author(s)
      牧野雄一、坂上英充、藤田征弘、滝山由美、羽田勝計
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Presentation] 低酸素応答システムよる生体機能調節機構2011

    • Author(s)
      牧野雄一
    • Organizer
      第45回北海道リウマチ膠原病談話会 教育講演
    • Place of Presentation
      札幌市
    • Year and Date
      2011-10-29
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Presentation] HIF-1αは骨格筋におけるインスリン依存性糖取込みの制御に重要である2011

    • Author(s)
      牧野雄一、坂上英充、藤田征弘、滝山由美、藤代大介、児玉暁、小林厚志、小村景司、岡本健作、羽田勝計
    • Organizer
      第29回内分泌代謝学サマーセミナー
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-23591453
  • [Presentation] 糖尿病性腎症糸球体病変における転写因子HIF-1の活性化2010

    • Author(s)
      牧野雄一, 他
    • Organizer
      第3回生活習慣病の転写・シグナルネットワーク研究会
    • Place of Presentation
      鎌倉市
    • Year and Date
      2010-02-20
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Presentation] Role of HIF-1α in regulation of insulin-dependent glucose uptake by Skeletal Muscle Cells2010

    • Author(s)
      Makino Y, et al.
    • Organizer
      The 3^<rd> Insulin Resistance in Metabolic Disease Forum
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2010-11-21
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Presentation] The Glucose-Responsive Transcription Factor ChREBP Activates HIF-1-Mediated Gene Expression in Glomerular Mesangial Cells2010

    • Author(s)
      Makino Y, et al
    • Organizer
      American Diabetes Association 70^<th> Scientific Sessions
    • Place of Presentation
      Orlando, USA
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Presentation] Role of hypoxia-independent activation of HIF-1 by high glucose in diabetic glomerulopathy2010

    • Author(s)
      Makino Y, et al
    • Organizer
      Keystone symposia, Hypoxia : Molecular mechanisms of oxygen sensing and response pathways
    • Place of Presentation
      Keystone, USA
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Presentation] 低酸素応答性転写因子群による遺伝子発現調節機構2010

    • Author(s)
      牧野雄一
    • Organizer
      第98回北海道癌談話会例会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-09-19
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Presentation] High glucose activates hypoxia-inducible factor-mediated signals via carbohydrate response element binding protein in human glomerular mesangial cells2009

    • Author(s)
      Makino Y, et al
    • Organizer
      American Diabetes Association 69^<th> Scientific Sessions
    • Place of Presentation
      New Orleans, USA
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Presentation] High glucose activates the hypoxia-inducible factor-1a (HIF-1a)-mediated gene expression in human glomerular mesangial cells.2009

    • Author(s)
      Makino Y, et al
    • Organizer
      The 15^<th> Korea-Japan Symposium on Diabetes Mellitus
    • Place of Presentation
      Jeju, Kores
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Presentation] 低酸素応答性転写因子による生体機能調節機構2009

    • Author(s)
      牧野雄一
    • Organizer
      日本生化学会北海道支部・日本生物物理学会北海道支部・北海道分子生物研究会 2009年度合同シンポジウム
    • Place of Presentation
      札幌市
    • Year and Date
      2009-11-13
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Presentation] 血管新生抑制分子IPASによるコラーゲン誘導関節炎の抑制2009

    • Author(s)
      牧野雄一, 他
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京都
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Presentation] 炎症制御における低酸素誘導性転写因子群の役割2009

    • Author(s)
      牧野雄一
    • Organizer
      日本外科代謝栄養学会第46回学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2009-07-09
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Presentation] インスリン依存性糖取込みにおけるHIF-1αの役割2009

    • Author(s)
      牧野雄一, 他
    • Organizer
      第7回がんとハイポキシア研究会
    • Place of Presentation
      京都市
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Presentation] 高グルコースはメサンギウム細胞においてHIF-1を介した転写調節系を作動させる2008

    • Author(s)
      牧野雄一, 他
    • Organizer
      第23回日本糖尿病合併症学会
    • Place of Presentation
      日本都市センター、東京都
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Presentation] 高グルコースによるHIFシグナルの活性化2008

    • Author(s)
      牧野雄一, 他
    • Organizer
      第6回がんとハイポキシア研究会
    • Place of Presentation
      広島市
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Presentation] Negative feedback regulation of gene expression in hypoxic cells2008

    • Author(s)
      Makino Y.
    • Organizer
      The 36th Annual Meeting of International Society on Oxygen Transport to Tissue
    • Place of Presentation
      Sapporo, Japan(Invited lecture 7)
    • Data Source
      KAKENHI-PROJECT-20591181
  • [Presentation] 膠原病性肺高血圧症におけるHypoxia inducible factor-3α(HIF-3α)遺伝子一塩基多型(SNP)とHIFシグナルの変容

    • Author(s)
      牧野雄一、水元克俊、吉本良太、江口耕平、藤代大介、児玉暁、小林厚志、岡本健作、川口鎮司、羽田勝計
    • Organizer
      日本臨床分子医学会
    • Place of Presentation
      京都市
    • Year and Date
      2015-04-10 – 2015-04-11
    • Data Source
      KAKENHI-PROJECT-26461456
  • [Presentation] グルコース応答性転写因子ChREBPはメサンギウム細胞においてplatelet-derived growth factor(PDGF)-C発現を誘導する

    • Author(s)
      牧野雄一、橘内博哉、水元克俊、柳町剛司、Kuralay Atageldiyeva、 藤田征弘、安孫子亜津子、滝山由美、羽田勝計
    • Organizer
      第51回日本臨床分子医学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2014-04-11 – 2014-04-12
    • Data Source
      KAKENHI-PROJECT-24390229
  • [Presentation] Genome location analysis identified platelet derived growth factor-C (PDGF-C) as a target gene of carbohydrate response element binding protein in glomerular mesnagial cells in high glucose ambience

    • Author(s)
      YUICHI MAKINO, HIROYA KITSUNAI, KURALAY ATAGELDIYEVA, KATSUTOSHI MIZUMOTO, TSUYOSHI YANAGIMACHI, YUKIHIRO FUJITA, ATSUKO ABIKO, YUMI TAKIYAMA, MASAKAZU HANEDA
    • Organizer
      Japan Korea diabetic nephropathy study group
    • Place of Presentation
      Kanazawa, JApan
    • Year and Date
      2014-09-26 – 2014-09-28
    • Data Source
      KAKENHI-PROJECT-24390229
  • [Presentation] Genome Wide Analysis Of High Glucose-mediated Gene Regulation In Glomerular Mesangial Cells; Induction Of Platelet Derived Growth Factor-C Via Carbohydrate Response Element Binding Protein In Diabetic Kidney

    • Author(s)
      YUICHI MAKINO, HIROYA KITSUNAI, KATSUTOSHI MIZUMOTO, HIDEMITSU SAKAGAMI, TSUYOSHI YANAGIMACHI, YUKIHIRO FUJITA, ATSUKO ABIKO, YUMI TAKIYAMA, MASAKAZU HANEDA
    • Organizer
      American Diabetes Association: 74th Scientific Sessions
    • Place of Presentation
      米国、サンフランシスコ市
    • Year and Date
      2014-06-12 – 2014-06-18
    • Data Source
      KAKENHI-PROJECT-24390229
  • 1.  田中 廣壽 (00171794)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  川口 鎮司 (90297549)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 3.  HIRANO Fuminori (60250552)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  OKAMOTO Kensaku (80396879)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 5.  HANEDA Masakazu (00124751)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 28 results
  • 6.  KOMURA Keiji (10396385)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  FUJITA YUKIHIRO (20451461)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 8.  本庄 潤
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  滝山 由美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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