HAMAGUCHI Isao 浜口功

Researcher Number	90348780
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2020: 国立感染症研究所, 血液・安全性研究部, 部長 2013 – 2015: 国立感染症研究所, その他部局等, その他 2009 – 2012: National Institute of Infectious Diseases, 血液・安全性研究部, 部長 2008: National Institute of Infectious Diseases, 国立感染症研究所血液・安全性研究部, 部長 2008: National Institute of Infectious Diseases, 血液・安全性研究部 … More 2004 – 2007: National Institute of Infectious Diseases, Department of Safety Research on Blood and Biological Products, Chief, 血液・安全性研究部, 室長 2004: 国立感染症研究所, 血液安全性研究部, 室長 2003: 慶應義塾大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator siRNA / RPS19 / Diamond-Blackfan anemia / HTLV-1 / ヒト化マウス / 先天性赤芽球癆 / 潜伏感染 / モデルマウス / 造血幹細胞 / in situ hybridization … More / In situ hybridization / PVL / in situ hybridization法 / マウスモデル / 胎盤感染 / 水平感染 / STLV-1 / 経口感染 / 免疫不全マウス / キャリア / GO arrest / G1期停止 / G0期停止 / Red cell production / knockout mouse / hematopoietic stem cells / ハイブリッドベクター / レンチウイルスベクター / 赤血球産生 / 遺伝子欠損マウス / ATL幹細胞 / HTLV-1感染モデル / 遺伝子コピー数 / 検出システム / リボソームタンパク / 先天性赤芽球癆(DBA) / DBA遺伝子 / アレル欠失 / リボソームタンパク質 / バイオマーカー / In situ ハイブリダイゼーション / 未分化性維持 / トランスジェニックマウス / 生殖幹細胞 / 血液内科学 Less

Elucidation of the mechanism of latent HTLV-1 infection for preventing from ATL onset of HTLV-1 carriersPrincipal Investigator
- Principal Investigator
  
  Hamaguchi Isao
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Institute of Infectious Diseases
Development of HTLV-1 carrier model mice aming for preventing ATL developmentPrincipal Investigator
- Principal Investigator
  
  Hamaguchi Isao
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Institute of Infectious Diseases
Identification and functional analysis of ATL cancer stem cells using a humanized micePrincipal Investigator
- Principal Investigator
  
  HAMAGUCHI Isao
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Institute of Infectious Diseases
Development of the biomarker for th e clinical diagnosis of Diamond-Blackfan AnemiaPrincipal Investigator
- Principal Investigator
  
  HAMAGUCHI Isao
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Institute of Infectious Diseases
Identification of the common factors specific for tissue stem cells and the functional analysis of themPrincipal Investigator
- Principal Investigator
  
  浜口功
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Institute of Infectious Diseases
Pathological analysis of ribosomal protein S19 deficient Diamond-Blackfan anemiaPrincipal Investigator
- Principal Investigator
  
  HAMAGUCHI Isao
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Institute of Infectious Diseases
Development of safety vector for the gene therapy of ribosomal protein S19 deficient Diamond-Blackfan anemiaPrincipal Investigator
- Principal Investigator
  
  HAMAGUCHI Isao
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Institute of Infectious Diseases
  Keio University

[Book] Diamond-Blackfan貧血におけるリボソーム機能異常(血液診療エキスパート-貧血)2010
- Author(s)
  倉光球、浜口功
- Total Pages
  3
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-21591228
[Book] Diamond-Blackfan貧血におけるリボゾーム機能異常、血液診療エキスパート2010
- Author(s)
  倉光球、浜口功
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-21591228
[Book] 血液診療エキスパート貧血 Diamond-Blackfan 貧血におけるリボソーム機能異常2010
- Author(s)
  倉光球, 浜口功
- Total Pages
  3
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-21591228
[Journal Article] First case of molecularly identified and genetically characterized human T-cell leukemia virus type 2 infection in a pregnant woman in non-endemic Japan2021
- Author(s)
  Kuramitsu Madoka、Okuma Kazu、Horiya Madoka、Sekizuka Tsuyoshi、Kaneko Noriaki、Saito Ema、Sokunaga Jun、Kuroda Makoto、Hamaguchi Isao
- Journal Title
  
  Journal of Virological Methods
  
  Volume: 287 Pages: 114005-114005
- DOI
  10.1016/j.jviromet.2020.114005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-20K07670
[Journal Article] HTLV-1 targets human placental trophoblasts in seropositive pregnant women2020
- Author(s)
  Tezuka Kenta、Fuchi Naoki、Okuma Kazu、Tsukiyama Takashi、Miura Shoko、Hasegawa Yuri、Nagata Ai、Komatsu Nahoko、Hasegawa Hiroo、Sasaki Daisuke、Sasaki Eita、Mizukami Takuo、Kuramitsu Madoka、Matsuoka Sahoko、Yanagihara Katsunori、Miura Kiyonori、Hamaguchi Isao
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 130 Issue: 11 Pages: 6171-6186
- DOI
  10.1172/jci135525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09265, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-18K16805, KAKENHI-PROJECT-19K16032, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-18K08378
[Journal Article] In vitro Evaluation of the Safety of Adalimumab for the Eye Under HTLV-1 Infection Status: A Preliminary Study2020
- Author(s)
  Kurozumi-Karube Hisako、Kamoi Koju、Ando Naoko、Uchida Minami、Hamaguchi Isao、Ohno-Matsui Kyoko
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 11 Pages: 522579-522579
- DOI
  10.3389/fmicb.2020.522579
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09824, KAKENHI-PROJECT-18K08378
[Journal Article] Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques2020
- Author(s)
  Murata Megumi、Yasunaga Jun-ichirou、Washizaki Ayaka、Seki Yohei、Kuramitsu Madoka、Tan Wei Keat、Hu Anna、Okuma Kazu、Hamaguchi Isao、Mizukami Takuo、Matsuoka Masao、Akari Hirofumi
- Journal Title
  
  Retrovirology
  
  Volume: 17 Issue: 1 Pages: 1-10
- DOI
  10.1186/s12977-020-00525-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-19H03689, KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-20H03514
[Journal Article] Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells2020
- Author(s)
  Ikebe E, Matsuoka S, Tezuka K, Kuramitsu M, Okuma K, Nakashima M,, Seiichiro Kobayashi S, Makiyama J, Yamagishi M, Oyadomari S, Uchimaru K, Hamaguchi I
- Journal Title
  
  Blood adv
  
  Volume: 4 Issue: 9 Pages: 1845-1858
- DOI
  10.1182/bloodadvances.2019001139
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-19K16032, KAKENHI-PROJECT-20K17390, KAKENHI-PROJECT-19H02853, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-19K16580
[Journal Article] Adult T-cell leukemia/lymphoma-related ocular manifestations: analysis of the first large-scale nationwide survey2019
- Author(s)
  Kamoi K, Okayama A, Izumo S, Hamaguchi I, Uchimaru K, Tojo A,Ohno-Matsui K
- Journal Title
  
  Front Microbiol
  
  Volume: 9 Pages: 3240-3240
- DOI
  10.3389/fmicb.2018.03240
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17K11476
[Journal Article] Development and evaluation of human T-cell leukemia virus-1 and -2 multiplex quantitative PCR2019
- Author(s)
  Kuramitsu M, Okuma K, Tezuka K, Nakamura H, Sagara Y, Kurane I, Hamaguchi I
- Journal Title
  
  Microbiol. Immunol.
  
  Volume: 63 Issue: 1 Pages: 458-464
- DOI
  10.1038/s41598-019-52686-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-19K12873, KAKENHI-PROJECT-16H06277
[Journal Article] A novel neuropilin-1 binding sequence in the human T-cell lymphotropic virus type 1 envelope glycoprotein2018
- Author(s)
  Kusunoki H, Tanaka T, Kohno T, Matsuhashi K, Hosoda K, Wakamatsu K, Hamaguchi I
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1866 Issue: 4 Pages: 541-548
- DOI
  10.1016/j.bbapap.2018.02.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09462, KAKENHI-PROJECT-17K07301
[Journal Article] Development of reference material with assigned value for human T-cell leukemia virus type 1 quantitative PCR in Japan2018
- Author(s)
  Kuramitsu M、Okuma K、Nakashima M、Sato T、Sasaki D、Hasegawa H、Umeki K、Kubota R、Sasada K、Sobata R、Matsumoto C、Kaneko N、Tezuka K、Matsuoka S、Utsunomiya A、Koh KR、Ogata M、Ishitsuka K、Taki M、Nosaka K、Uchimaru K、Iwanaga M、Sagara Y、Yamano Y、Okayama A、Miura K et al
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 62 Issue: 10 Pages: 673-676
- DOI
  10.1111/1348-0421.12644
- NAID
  40021702629
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-16H05248, KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-16H05823, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-16K09702, KAKENHI-PROJECT-16H06277
[Journal Article] Control of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor.2018
- Author(s)
  Tezuka K, Okuma K, Kuramitsu M, Matsuoka S, Tanaka R, Tanaka Y, Hamaguchi I.
- Journal Title
  
  Journal of Virology
  
  Volume: 92(4) Issue: 4
- DOI
  10.1128/jvi.01885-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08439, KAKENHI-PROJECT-15K09462, KAKENHI-PROJECT-16K19590
[Journal Article] Proviral features of human T cell leukemia virus type 1 in carriers with indeterminate western blot analysis results.2017
- Author(s)
  Kuramitsu M, Sekizuka T, Yamochi T, Firouzi S, Sato T, Umeki K, Sasaki D, Hasegawa H, Kubota R, Sobata R, Matsumoto C, Kaneko N, Momose H, Araki K, Saito M, Nosaka K, Utsunomiya A, Koh K, Ogata M, Uchimaru K, Iwanaga M, Sagara Y, Yamano Y, et al.
- Journal Title
  
  J Clin Microbiol.
  
  Volume: 55(9) Issue: 9 Pages: 2838-2849
- DOI
  10.1128/jcm.00659-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09702, KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-17K15044, KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-16H05823, KAKENHI-PROJECT-17H03594, KAKENHI-PROJECT-15K08647, KAKENHI-PROJECT-15K09462, KAKENHI-PROJECT-15K14388, KAKENHI-PROJECT-16H06277
[Journal Article] Incidence of new HTLV-1 infections among adolescents and adults in Japan: a nationwide retrospective cohort analysis of repeat blood donors.2016
- Author(s)
  Satake M, Iwanaga M, Sagara Y, Watanabe T, Okuma K, Hamaguchi I
- Journal Title
  
  Lancet Infect Dis
  
  Volume: 16 Issue: 11 Pages: 1246-1254
- DOI
  10.1016/s1473-3099(16)30252-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09462, KAKENHI-PROJECT-16H06277
[Journal Article] Impact of the SCF signaling pathway on leukemia stem cell-mediated ATL initiation and progression in an HBZ transgenic mouse model.2016
- Author(s)
  Kuribayashi W, Takizawa K, Sugata K, Kuramitsu M, Momose H, Sasaki E, Hiradate Y, Furuhata K, Asada Y, Iwama A, Matsuoka M, Mizukami T*, Hamaguchi I*.
- Journal Title
  
  Oncotarget
  
  Volume: 7(32) Issue: 32 Pages: 51027-51043
- DOI
  10.18632/oncotarget.10210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461440, KAKENHI-PROJECT-15K09462, KAKENHI-PROJECT-16K09833, KAKENHI-PROJECT-16K10377
[Journal Article] Furin-dependent CCL17-fused recombinant toxin controls HTLV-1 infection by targeting and eliminating infected CCR4-expressing cells in vitro and in vivo.2015
- Author(s)
  Okuma K, Hiyoshi M, Tateyama S, Takizawa K, Saito M, Kuramitsu M, Araki K, Morishita K, Okada S, Yamamoto N, Biragyn A, Yamaguchi K, Hamaguchi I.
- Journal Title
  
  Retrovirology
  
  Volume: 12 Issue: 1 Pages: 1-14
- DOI
  10.1186/s12977-015-0199-8
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08439, KAKENHI-PROJECT-15K09462, KAKENHI-PROJECT-15K15087, KAKENHI-PROJECT-25293081
[Journal Article] Identification of TL-Om1, an ATL Cell Line, as a Reference Material for Human T-Lymphotropic Virus 1 Quantitative PCR.2015
- Author(s)
  Kuramitsu M, Okuma K, Yamagishi M, Yamochi T, Firouzi S, Momose H, Mizukami T, Takizawa K, Araki K, Sugamura K, Yamaguchi K, Watanabe T, Hamaguchi I.
- Journal Title
  
  Journal of Clinical Microbiology
  
  Volume: 53 Issue: 2 Pages: 587-596
- DOI
  10.1128/jcm.02254-14
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J06916, KAKENHI-PROJECT-24570142, KAKENHI-PROJECT-24591383, KAKENHI-PROJECT-24591414, KAKENHI-PROJECT-25290047, KAKENHI-PROJECT-25860798, KAKENHI-PROJECT-26293226, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15K06848, KAKENHI-PROJECT-25461440
[Journal Article] Extensive gene deletions in Japanese patients with Diamond. Blackfan anemia2012
- Author(s)
  Kuramitsu M, Sato-Otsubo A, Morio T, Takagi M, Toki T, Terui K, Wang R, Kanno H, Ohga S, Ohara A, Kojima S, Kitoh T, Goi K, Kudo K, Matsubayashi T, Mizue N, Ozeki M, Masumi A, Momose H, Takizawa K, Mizukami T, Yamaguchi K, Ogawa S, Ito E, and Hamaguchi I
- Journal Title
  
  Blood
  
  Volume: 119 Pages: 2376-2384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591228
[Journal Article] 倉光球: Diamond-Blackfan貧血の分子異常2010
- Author(s)
  浜口功
- Journal Title
  
  細胞
  
  Volume: 第42巻7号 Pages: 16-19
- Data Source
  KAKENHI-PROJECT-21591228
[Journal Article] Ribosomal proteinと造血障害2010
- Author(s)
  浜口功
- Journal Title
  
  臨床血液
  
  Volume: 第51巻8号 Pages: 638-645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591228
[Journal Article] Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity2008
- Author(s)
  Ohmura M, Naka K, Hoshii T, Muraguchi T, Shugo H, Tamase A, Uema N, Ooshio T, Arai F, Takubo K, Nagamatsu G, Hamaguchi I, Takagi M, Ishihara M, Sakurada K, Miyaji H, Suda T, Hirao A
- Journal Title
  
  Stem Cells 26
  
  Pages: 3237-3246
- Data Source
  KAKENHI-PROJECT-19591148
[Journal Article] Identification of transcripts commonly expressed in both hematopoietic and germline stem cells.2008
- Author(s)
  Mizukami T, Kuramitsu M, Takizawa K, Momose H, Masumi A, Naito S, Iwama A, Ogawa T, Noce T, Hamaguchi I, and Yamaguchi K
- Journal Title
  
  Stem Cell & Dev. 17
  
  Pages: 67-80
- Data Source
  KAKENHI-PROJECT-19591148
[Journal Article] Deficient RPS19 protein production induces cell cycle arrest in erythroid progenitor cells.2008
- Author(s)
  Kuramitsu M, Hamaguchi I, Mizukami T, Masumi A, Momose H, Takizawa K, Mochizuki M, Naito S, Yamaguchi K
- Journal Title
  
  Brit. J. Haematol. 140
  
  Pages: 348-359
- Data Source
  KAKENHI-PROJECT-19591148
[Journal Article] RPS19 deficiency leads to reduced proliferation and increased apoptosis but does not affect terminal erythroid differentiatio in a cell line model of Diamond-Blackfan anemia.2008
- Author(s)
  Miyake K, Utsugisawa T, Flygare J, Kiefer T, Hamaguchi I, Richiter J, Karlsson S
- Journal Title
  
  Stem Cells 26
  
  Pages: 323-329
- Data Source
  KAKENHI-PROJECT-19591148
[Journal Article] Two vaccine toxicity-related genes Agp and Hpx could prove useful fr pertussis vaccine safety control2007
- Author(s)
  Isao Hamaguchi
- Journal Title
  
  Vaccine 25
  
  Pages: 3355-3364
- Data Source
  KAKENHI-PROJECT-17591021
[Journal Article] Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival.2006
- Author(s)
  Hamaguchi I, Morisada T, Azuma M, Murakami K, Kuramitsu M, Mizukami T, Ohbo K, Yamaguchi K, Oike Y, Dumont DJ, Suda T
- Journal Title
  
  Blood 107
  
  Pages: 1207-1213
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591021
[Journal Article] Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival.2006
- Author(s)
  Isao Hamaguchi et al.
- Journal Title
  
  Blood 107
  
  Pages: 1207-1213
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591021
[Journal Article] CTX family cell adhesion molecule, JAM4, expresses in stem cell-and progenitor cell-populations of both male germ cell and hematopoietic cell lineages.2006
- Author(s)
  Nagamatsu G, Ohmura M, Mizukami T, Hamaguchi I, Hirabayashi S, Yoshida S, Hata Y, Suda T, Ohbo K
- Journal Title
  
  Mol.Cell.Biol 26
  
  Pages: 8498-8506
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591021
[Journal Article] Deficiency of Ribosomal Protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia.2005
- Author(s)
  Flygare J, Kiefer T, Miyake K, Utsugisawa T, Hamaguchi I, Da Costa L, Richter J, Davey EJ, Matsson H, Dahl N, Wiznerowicz M, Torono D, Karlsson S
- Journal Title
  
  Blood 105
  
  Pages: 4627-4634
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591025
[Journal Article] A quantitative matrigel assay for assessing repopulating capacity of prostate stem cells.2005
- Author(s)
  Azuma M, Hirao A, Takubo K, Hamaguchi I, Kitamura T, Suda T
- Journal Title
  
  Biochem Biophys.Rec.Commun. 338
  
  Pages: 1164-1170
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591021
[Journal Article] Karlsson S : Deficiency of Ribosomal Protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia.2005
- Author(s)
  Flygare J, Kiefer T, Miyake K, Utsugisawa T, Hamaguchi I, Da Costa L, Richter J, Davey EJ, Matsson H, Dahl N, Wiznerowicz M, Torono D
- Journal Title
  
  Blood 105
  
  Pages: 4627-4634
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591021
[Journal Article] Targeted Disruption of the Ribosomal Protein S19 Gene Is Lethal Prior to Implantation.2004
- Author(s)
  Matsson H, Davey E, Draptchinskaia N, Hamaguchi I, Ooka A, Leveen Per, Forsberg E, Karlsson S, Dahl N
- Journal Title
  
  Mol.Cell.Biol. 24
  
  Pages: 4032-4037
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591025
[Journal Article] Proliferation deficiency of multipotent hematopoietic progenitors in ribosomal protein S19(RPS19)-deficient diamond-Blackfan anemia improves following RPS19 gene transfer.2003
- Author(s)
  Hamaguchi I, Flygare J, Nishiura H, Brun AC, Ooka A, Kiefer T, Ma Z, Dahl N, Richter J, Karlsson S
- Journal Title
  
  Mol Ther. 5
  
  Pages: 613-622
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591025
[Journal Article] Proliferation deficiency of multipotent hematopoietic progenitors in ribosal protein S19 (RPS19)-deficient diamond-Blackfan anemia improves following RPS19 gene transfer2003
- Author(s)
  Isao Hamaguchi et al.
- Journal Title
  
  Mol Ther. 5
  
  Pages: 613-622
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591025
[Journal Article] Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia / lymphoma (ATL).
- Author(s)
  Yamazaki J, Mizukami T, Takizawa K, Kuramitsu M, Momose H, Masumi A, Ami Y, Hasegawa H, Hall WW, Tsujimoto H, Hamaguchi I, Yamaguchi K
- Journal Title
  
  Blood in press
  
  Pages: 0-0
- Data Source
  KAKENHI-PROJECT-19591148
[Patent] 組換え水疱性口内炎ウイルスを用いたワクチン・治療薬開発に向けたモニタリングのためのウイルスベクター定量法2017
- Inventor(s)
  手塚健太、大隈和、浜口功
- Industrial Property Rights Holder
  手塚健太、大隈和、浜口功
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-131361
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15K09462
[Patent] HTLV-1プロウイルス検出のためのプライマーセット、及びそれを用いた検出方法2013
- Inventor(s)
  倉光球、浜口功、大隈和
- Industrial Property Rights Holder
  倉光球、浜口功、大隈和
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-196247
- Filing Date
  2013-09-20
- Data Source
  KAKENHI-PROJECT-24591414
[Presentation] 1.小胞体ストレス応答を標的とした新規抗HTLV-1薬の開発2020
- Author(s)
  池辺詠美, 松岡佐保子, 手塚健太, 倉光球, 大隈和, 中島誠, 小林誠一郎, 牧山純也, 山岸誠, 親泊政一, 内丸薫, 浜口功
- Organizer
  第93 回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08378
[Presentation] HTLV-1検査法の改良と開発2019
- Author(s)
  浜口功
- Organizer
  第6回日本HTLV-1学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08378
[Presentation] HTLV-1プロウイルス陽性のWB判定保留例に対するLIAの検討2019
- Author(s)
  倉光球、大隈和、相良康子、中村仁美、手塚健太、浜口功
- Organizer
  第6回日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-18K08378
[Presentation] キャリア妊婦におけるHTLV-1経胎盤感染の実態解明の試み2019
- Author(s)
  手塚健太、淵直樹、大隈和、築山尚史、長谷川ゆり、長谷川寛雄、佐々木大介、三浦生子、東島愛、佐々木永太、水上拓郎、倉光球、松岡佐保子、増﨑英明、三浦清徳、浜口功
- Organizer
  第6回日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-18K08378
[Presentation] 血液製剤の安全性強化に向けたHTLV-1/2高感度マルチプレックス核酸検査法の開発2018
- Author(s)
  大隈和、倉光球、手塚健太、倉根一郎、浜口功
- Organizer
  日本輸血・細胞治療学会
- Data Source
  KAKENHI-PROJECT-18K08378
[Presentation] 献血検体から見出された抗体陰性HTLV-1キャリア2018
- Author(s)
  相良康子、中村仁美、倉光球、相良康弘、松永克希、平山秀明、島村益弘、岩永正子、大隈和、浜口功、入田和夫
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-18K08378
[Presentation] HTLV-1定量PCRの標準化のための参照品の作成2018
- Author(s)
  倉光球、大隈和、内丸薫、山野嘉久、長谷川寛雄、野坂生郷、岡山昭彦、久保田龍二、佐竹正博、金子典章、渡邉俊樹、浜口功
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-18K08378
[Presentation] Highly sensitive detection of plus- and minus-strand HTLV-1 mRNAs by RNA in situ hybridization in a humanized mouse model2018
- Author(s)
  Tezuka K, Mizukami T, Sasaki E, Kuramitsu M, Matsuoka S, Okuma K, Hamaguchi I
- Organizer
  日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-18K08378
[Presentation] HTLV-1/2マルチプレックス核酸検査法の開発と臨床検体を用いた評価2018
- Author(s)
  大隈和、倉光球、手塚健太、中村仁美、相良康子、浜口功
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-18K08378
[Presentation] Targeting and Eliminating HTLV-1-infected Cells with Cytolytic Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor2017
- Author(s)
  Kenta Tezuka, Kazu Okuma, Madoka Kuramitsu, Yuetsu Tanaka, Reiko Tanaka, Isao Hamaguchi
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  東京
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-15K09462
[Presentation] HTLV-1受容体をコードする組換え水疱性口内炎ウイルスを用いたHTLV-1感染の制御2017
- Author(s)
  手塚健太、大隈和、倉光球、田中勇悦、田中礼子、浜口功
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-15K09462
[Presentation] The c-kit-SCF signaling in the leukemic stem cells development and differentiation in ATL model mice2015
- Author(s)
  Kuribayashi W, Mizukami T, Takizawa K, Sugata K, Kuramitsu M, Kojima K, Momose H, Asada Y, Iwama A, Matsuoka M, Hamaguchi I
- Organizer
  日本血液学会
- Place of Presentation
  金沢
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K09462
[Presentation] Identification of cancer stem cell candidates in ATL mouse model of HBZ transgenic mice2013
- Author(s)
  Wakako Kuribayashi, Takuo Mizukami, Masao Matsuoka, Isao Hamaguchi
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591414
[Presentation] The osteoclast targeting therapy in bone metastasis for a mouse model of adult T cell leukemia2013
- Author(s)
  Takuo Mizukami, Kazuya Takizawa, Jumpei Yamazaki, Wakako Kuribayashi , Madoka Kuramitsu, Ryuji Hiramatsu, William W Hall, Hideki Hasegawa, Kazunari Yamaguchi, Isao Hamaguchi
- Organizer
  アメリカ血液学会
- Place of Presentation
  ニューオーリンズ
- Data Source
  KAKENHI-PROJECT-24591414
[Presentation] Identification of cancer stem cell candidates in ATL mouse model of HBZ-transgenic mouse2013
- Author(s)
  Wakako Kuribayashi, Kazuya Takizawa, Madoka Kuramistu, Yoshihisa Asada, Masao Mastuoka, Takuo Mizukami, Isao Hamaguchi
- Organizer
  日本血液学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24591414
[Presentation] Extensive gene deletions in Japanese patients with Diamond Blackfan anemia2011
- Author(s)
  Kuramitsu M, Matsubara A, Morio T, Takagi M, Toki T, Terui K, Wang R, Kanno H, Ohga S, Ohara A, Masumi A, Momose H, Mizukami T, Takizawa K, Yamaguchi K, Ogawa S, Ito E, Hamaguchi I
- Organizer
  第73回日本血液学会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-21591228
[Presentation] A novel method to analyze genomic copy number of Diamond Blackfan anemia responsible genes2010
- Author(s)
  Kuramitsu M, Morio T, Takagi M, Ozeki M, Masumi A, Mizukami T, Momose H, Takizawa K, Etsuro I, Yamaguchi K, Hamaguchi I
- Organizer
  第72回日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21591228
[Presentation] Deficiency of Ribosomal protein associated with Diamond Blackfan anemia induces autophagy2010
- Author(s)
  Kuramitsu K, Kasai M, Masumi A, Mizukami T, Momose H, Takizawa K, Yamaguchi K, Hamaguchi I
- Organizer
  第72回日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21591228
[Presentation] New Determination Method for Extensive Gene Deletions in Diamond-Blackfan Anemia2010
- Author(s)
  Kuramitsu M, Morio T, Takagi M, Toki T, Terui K, Wang R, Masumi A, Mizukami T, Momose H, Takizawa K, Yamaguchi K, Ito E, Hamaguchi I
- Organizer
  52^<nd> ASH^[(R)] Annual Meeting and Exposition
- Place of Presentation
  Orlando
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21591228
[Presentation] 先天性赤芽球癆(Diamond blackfan anemia)原因遺伝子によるオートファジー活性化の解析2009
- Author(s)
  倉光球、水上拓郎、益見厚子、百瀬暖佳、滝沢和也、笠井道行、山口一成、浜口功
- Organizer
  第71回日本血液学会
- Place of Presentation
  京都
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21591228
[Presentation] Ribosomal proteinと造血障害2009
- Author(s)
  浜口功
- Organizer
  第71回日本血液学会
- Place of Presentation
  京都
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21591228
[Presentation] Ribosome protein と造血障害2009
- Author(s)
  浜口功
- Organizer
  日本血液学会
- Place of Presentation
  京都国際会議場
- Year and Date
  2009-10-25
- Data Source
  KAKENHI-PROJECT-21591228
[Presentation] 脾臓における造血幹細胞ニッチ細胞の解析2008
- Author(s)
  水上拓郎、浜口功、滝澤和也、倉光球、百瀬暖佳、内藤誠之郎、益見厚子、岡田誠治、山口一成
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19591148
[Presentation] Identification and Characterization of a Hematopoietic Stem Cell Niche in Spleen2008
- Author(s)
  Mizukami T, Hamaguchi I, Takizawa K, Kuramitsu M, Momose H, Naito S, Masumi A, Okada S, and Yamaguchi K
- Organizer
  第50回アメリカ血液学会年会
- Place of Presentation
  San Francisco、California
- Data Source
  KAKENHI-PROJECT-19591148
[Presentation] 髄外造血機構を用いた造血幹細胞ニッチの解析2008
- Author(s)
  水上拓郎、浜口功、滝沢和也、倉光球、百瀬暖佳、内藤誠之郎、益見厚子、岡田誠治、山口一成
- Organizer
  第145回日本獣医学会総会
- Place of Presentation
  相模原
- Data Source
  KAKENHI-PROJECT-19591148
[Presentation] Identification of transcripts commonly expressed in both hematopoietic and germline stem cells.-Spp1 (Secreted phosphoprotein 1) is essential for the early niche formation in the bone marrow.2007
- Author(s)
  Mizukami T, Kuramitsu M, Takizawa K, Momose H, Mochizuki M, Masumi A, Naito S, Iwama A, Ogawa T, Noce T, Hamaguchi I, Yamaguchi K
- Organizer
  第5回国際幹細胞学会
- Place of Presentation
  Cairns、 Australia
- Data Source
  KAKENHI-PROJECT-19591148
[Presentation] 髄外造血機構を用いた造血幹細胞ニッチの解析2007
- Author(s)
  水上拓郎、浜口功、滝沢和也、倉光球、百瀬暖佳、内藤誠之郎、益見厚子、岡田誠治、山口一成
- Organizer
  第69回日本血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591148
[Presentation] The Role of osteoclasts during the ATL stem cell niche formation
- Author(s)
  Takuo Mizukami, Kazuya Takizawa, Shunsuke Hazama, Madoka Kuramitsu, Haruka Momose, Atsuko Masumi, Hideki Hasegawa, Kazunari Yamaguchi and Isao Hamaguchi
- Organizer
  日本血液学会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24591414
[Presentation] Identification and characterization of cancer stem cells in an HBZ transgenic mouse model of ATL
- Author(s)
  Kuribayashi W, Mizukami T, Takizawa K, Kuramitsu M, Asada Y, Iwama A, Matsuoka M, Hamaguchi I
- Organizer
  日本血液学会
- Place of Presentation
  大坂
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-24591414
[Presentation] Identification of Leukemic Stem Cells and Their Niche in Adult T Cell Leukemia Using the Tax-Transgenic Mouse Model
- Author(s)
  Takuo Mizukami, Kazuya Takizawa, Madoka Kuramitsu, Haruka Momose, Jumpei Yamazaki, Atsuko Masumi, William W Hall, Hideki Hasegawa, Kazunari Yamaguchi and Isao Hamaguchi
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  Atlanta Georgia World Congress Center
- Data Source
  KAKENHI-PROJECT-24591414
[Presentation] HTLV-1モデルマウスであるHBZ-Tgマウスにおける癌幹細胞の同定と機能解析
- Author(s)
  栗林和華子、水上拓郎、滝澤和也、倉光球、浅田善久、岩間厚志、松岡雅雄、浜口功
- Organizer
  日本HTLV-1学会
- Place of Presentation
  東京
- Year and Date
  2014-08-22 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-24591414

1. MIURA Kiyonori

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. MIURA Shoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. OKUMA Kazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. KURAMITSU Madoka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. SATO Tomoo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 鴨居功樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. FIROUZI Sanaz

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 水上拓郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAMAGUCHI Isao 浜口 功

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of latent HTLV-1 infection for preventing from ATL onset of HTLV-1 carriersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of HTLV-1 carrier model mice aming for preventing ATL developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and functional analysis of ATL cancer stem cells using a humanized micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the biomarker for th e clinical diagnosis of Diamond-Blackfan AnemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of the common factors specific for tissue stem cells and the functional analysis of themPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathological analysis of ribosomal protein S19 deficient Diamond-Blackfan anemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of safety vector for the gene therapy of ribosomal protein S19 deficient Diamond-Blackfan anemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Diamond-Blackfan貧血におけるリボソーム機能異常(血液診療エキスパート-貧血)2010

Author(s)

Total Pages

Publisher

Data Source

[Book] Diamond-Blackfan貧血におけるリボゾーム機能異常、血液診療エキスパート2010

Author(s)

Publisher

Data Source

[Book] 血液診療エキスパート 貧血 Diamond-Blackfan 貧血におけるリボソーム機能異常2010

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] First case of molecularly identified and genetically characterized human T-cell leukemia virus type 2 infection in a pregnant woman in non-endemic Japan2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HTLV-1 targets human placental trophoblasts in seropositive pregnant women2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vitro Evaluation of the Safety of Adalimumab for the Eye Under HTLV-1 Infection Status: A Preliminary Study2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques2020

Author(s)

Journal Title

DOI

Data Source

HAMAGUCHI Isao 浜口功

[Book] 血液診療エキスパート貧血 Diamond-Blackfan 貧血におけるリボソーム機能異常2010