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Iwai Yoshiko  岩井 佳子

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… Alternative Names

IWAI Yoshiko  岩井 佳子

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Researcher Number 90362467
Other IDs
Affiliation (Current) 2025: 日本医科大学, 大学院医学研究科, 大学院教授
Affiliation (based on the past Project Information) *help 2017 – 2023: 日本医科大学, 大学院医学研究科, 大学院教授
2013 – 2014: 産業医科大学, 医学部, 教授
2012: 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授
2007 – 2008: Tokyo Medical and Dental University, 難治疾患研究所, 特任講師
Review Section/Research Field
Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Pathobiological dentistry/Dental radiology / Immunology
Except Principal Investigator
Basic Section 48040:Medical biochemistry-related / Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 38050:Food sciences-related / Basic Section 59040:Nutrition science and health science-related / Tumor biology and related fields
Keywords
Principal Investigator
免疫チェックポイント / T細胞 / T細胞 / 樹状細胞 / 免疫学的記憶 / PD-L1 / PD-1 / T細胞疲弊 / バイオマーカー / がん免疫療法 / 細胞 … More
Except Principal Investigator
… More 免疫細胞 / 細胞接着 / Glycocalyx / シスリガンド / Siglec / LFA-1 / B細胞 / レクチン / シアル酸 / CD22 / 走化因子 / 自己免疫疾患 / 細胞遊走 / CNSループス / IgA / Tfh / 形質細胞 / IgG1 / IgE / IL-21 / 老化 / 酸化ストレス / 免疫学 / 腫瘍免疫 / ゲノムワイドスクリーニング / CRISPR/Cas9 / 免疫チェックポイント Less
  • Research Projects

    (9 results)
  • Research Products

    (13 results)
  • Co-Researchers

    (9 People)
  •  T細胞疲弊に関する免疫機能診断法の構築と病態解明Principal Investigator

    • Principal Investigator
      岩井 佳子
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Nippon Medical School
  •  パイエル板Tfhによる抗体産生制御:対立遺伝子排除の破綻とアレルギーの抑制

    • Principal Investigator
      橋口 昌章
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 38050:Food sciences-related
    • Research Institution
      Nippon Medical School
  •  CNSループス病態における免疫細胞の遊走制御機構の解明

    • Principal Investigator
      宮部 斉重
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      St. Marianna University School of Medicine
  •  Bリンパ球を用いたレクチンを起点とする細胞表面分子ネットワークの機能解明

    • Principal Investigator
      鍔田 武志
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Nihon University
  •  Biomarkers for T-cell immune responsePrincipal Investigator

    • Principal Investigator
      Iwai Yoshiko
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Nippon Medical School
  •  免疫細胞の分化と老化における活性酸素の機能の解明

    • Principal Investigator
      西槇 貴代美
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Nippon Medical School
  •  Genome-wide screening for genes involved in immune escape

    • Principal Investigator
      DOI Tomomitsu
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Tumor biology and related fields
    • Research Institution
      University of Occupational and Environmental Health, Japan
  •  Visualization of immune-inhibitory signaling in memory formationPrincipal Investigator

    • Principal Investigator
      IWAI Yoshiko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      University of Occupational and Environmental Health, Japan
      Tokyo Medical and Dental University
  •  The role of dendritic cells in regulation of memory CD8 T cell differentiationPrincipal Investigator

    • Principal Investigator
      IWAI Yoshiko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokyo Medical and Dental University

All 2024 2021 2020 2019 2018 2008 Other

All Journal Article Presentation

  • [Journal Article] Soluble PD-L1 with PD-1-binding capacity exists in the plasma of patients with non-small cell lung cancer2018

    • Author(s)
      Takeuchi Masahiro、Doi Tomomitsu、Obayashi Kunie、Hirai Ayako、Yoneda Kazue、Tanaka Fumihiro、Iwai Yoshiko
    • Journal Title

      Immunology letters

      Volume: 196 Pages: 155-160

    • DOI

      10.1016/j.imlet.2018.01.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19617, KAKENHI-PROJECT-16H01747
  • [Journal Article] Selective delivery ofbeta cell antigen to dendritic cells invivo leads to deletion and tolerance ofautoreactive CD8+ T cells in NOD mice2008

    • Author(s)
      Mukhopadhaya A, Hanafusa T, Jarchum I, Chen YG, Iwai Y, Serreze DV, Steinman RM, Tarbell KV, DiLorenzo TP
    • Journal Title

      Proc Natl Acad Sci USA 105(17)

      Pages: 6374-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19599007
  • [Journal Article] AnIFN-γ-IL-18signaling loop acceleratesmemory CD8+ Tcell proliferation2008

    • Author(s)
      Yoshiko Iwai, Hiroaki Hemmi, Olga Mizenina, Shoko Kuroda, Koji Suda,and Ralph M. Steinman
    • Journal Title

      PLoS ONE 3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19599007
  • [Journal Article] An IFN-γ-IL-18 signaling loop accelerates memory CD8+ T cell proliferation2008

    • Author(s)
      Yoshiko Iwai, Hiroaki Hemmi, Olga Mizenina, Shoko Kuroda, Koji Suda, Ralph M. Steinman
    • Journal Title

      PLoS ONE 3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19599007
  • [Journal Article] Selective Delivery of β Cell Antigen to Dendritic Cells In Vivo Leads to Deletion and Tolerance of Autoreactive CD8+T Cells in NOD Mice2008

    • Author(s)
      Arunika Mukhopadhaya, Tadashi Hanafusa, Irene Jarchum, Yi-Guang Chen, Yoshiko Iwai, David Serreze, Ralph Steinman, Kristin Tarbell, Teresa DiLorenzo
    • Journal Title

      PNAS (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19599007
  • [Presentation] Interleukin 21 commits IgG1+ cells not to undergo class switch to IgE but to differentiate into plasmablasts2024

    • Author(s)
      Masaaki Hashiguchi, Yoshiko Iwai
    • Organizer
      第52回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K05481
  • [Presentation] 糖およびアミノ酸代謝によるPD-1の糖鎖修飾およびリガンド結合能の制御2021

    • Author(s)
      安藤文彦、黒田聖子、岩井佳子
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-19K07783
  • [Presentation] がん免疫療法:T細胞免疫応答の制御と最近の進歩2021

    • Author(s)
      岩井佳子
    • Organizer
      第70回日本アレルギー学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K07783
  • [Presentation] がん免疫療法の分類と作用機序2020

    • Author(s)
      岩井 佳子
    • Organizer
      第58回日本癌治療学会(第26回教育セミナー)
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K07783
  • [Presentation] 酸化ストレスモニターマウスを用いた免疫細胞のin vitro解析2019

    • Author(s)
      西槙貴代美、上村尚美、岩井佳子
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19K11677
  • [Presentation] Soluble PD-L1 with PD-1-binding capacity as a biomarker for anti-PD-1/PD-L1 therapy for non-small cell lung cancer.2019

    • Author(s)
      Takeru Kashiwada, Kiyomi Nishimaki, Naomi Kamimura, Masahiro Seike, Akihiko Gemma, and Yoshiko Iwai.
    • Organizer
      第78回 日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07783
  • [Presentation] 血中のPD-1結合能を有する可溶性PD-L1(bsPD-L1)を用いた非小細胞肺癌の 免疫チェックポイント阻害薬の効果予測2019

    • Author(s)
      清家正博、西槇貴代美、上村尚美、柏田建、弦間昭彦、岩井佳子
    • Organizer
      第60回 日本肺癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07783
  • [Presentation] SIRT1とT細胞分化

    • Author(s)
      岩井 佳子
    • Organizer
      第15 回日本抗加齢医学会総会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-05-29 – 2015-05-31
    • Invited
    • Data Source
      KAKENHI-PROJECT-24592828
  • 1.  鍔田 武志 (80197756)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  DOI Tomomitsu (70437218)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  東 みゆき (90255654)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  西槇 貴代美 (00465345)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  橋口 昌章 (20372443)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  宮部 斉重 (70632313)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  赤津 ちづる (60735984)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  STEINMAN Ralph M.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 9.  NISHIMAKI Kiyomi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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