NISHIDA Kazuhiko 西田和彦

Researcher Number	90362681
Other IDs
Affiliation (based on the past Project Information) *help	2009 – 2011: Osaka University, 大学院・歯学研究科, 講師 2007 – 2008: 大阪大学, 歯学研究科, 助教 2003 – 2006: 大阪大学, 歯学研究科, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine
Keywords	Principal Investigator 心不全 / Heart Failure / p38 MAP Kinase / Cardioprotection / p38MAPキナーゼ / 心筋保護 / シグナル伝達 / 細胞死 / 分子心臓病態学 Except Principal Investigator 心不全 … More / ASK1 / アポトーシス / 細胞死 / apoptosis / reactive oxygen species / heart failure / 心不全モデル動物 / 遺伝子治療 / 活性酸素種 / オートファジー / ネクローシス / 心肥大 / 適応破綻 / 時間特異的 / 心筋特異的 / Cre-loxP / p38α Less

The mechanism of non-apoptotic cardiomyocyte cell deathPrincipal Investigator
- Principal Investigator
  
  NISHIDA Kazuhiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Elucidation of molecular mechanisms underlying cell death in heart failure
- Principal Investigator
  
  OTSU Kinya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Characterization of cardioprotective molecular mechanism via p38MAPK and new therapy for heart failurePrincipal Investigator
- Principal Investigator
  
  NISHIDA Kazuhiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  OSAKA UNIVERSITY
Elucidation of a role of ASK1 in the pathogenesis of heart failure and its application to therapeutics
- Principal Investigator
  
  OTSU Kinya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
心筋及び時間息異的p38α改変マウスによる心肥大から心不全への適応破綻機序の解明
- Principal Investigator
  
  増山理
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University

All 2011 2010 2009 2008 2007 2006 2004

All Journal Article

[Journal Article] Calpain protects the heart from hemodynamic stress2011
- Author(s)
  Taneike M, Mizote I, Morita T, Watanabe T, Hikoso S, Yamaguchi O, Takeda T, Oka T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Takeda J, Mochizuki N, Komuro I, Otsu K.
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 32170-32177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590929
[Journal Article] Activation of MTK1/ MEKK4 induces cardiomyocyte death and heart failure2010
- Author(s)
  Mizote I, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Tamai T, Oyabu J, Matsumura Y, Nishida K, Komuro I, Hori M, Otsu K.
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 48 Pages: 283-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590929
[Journal Article] Inhibition of autophagy in the heart induces age-related cardiomyopathy2010
- Author(s)
  Taneike M, Yamaguchi O, Nakai A, Hikoso S, Takeda T, Mizote I, Oka T, Tamai T, Oyabu J, Murakawa T, Nishida K, Shimizu T, Hori M, Komuro I, Shirasawa T, Mizushima N, Otsu K.
- Journal Title
  
  Autophagy
  
  Volume: 6 Pages: 600-606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590929
[Journal Article] The IkappaB kinase beta/ nuclear factor kappaB signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression2009
- Author(s)
  Hikoso S, Yamaguchi O, Nakano Y, Takeda T, Omiya S, Mizote I, Taneike M, Oka T, Tamai T, Oyabu J, Uno Y, Matsumura Y, Nishida K, Suzuki K, Kogo M, Hori M, Otsu K.
- Journal Title
  
  Circ Res
  
  Volume: 105 Pages: 70-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590929
[Journal Article] Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes2009
- Author(s)
  Shigemiki Omiya, Shungo Hikoso, Yukiko Imanishi, Atsuhiro Saito, Osamu Yamaguchi, Toshihiro Takeda, Isamu Mizote, Takafumi Oka, Manabu Taneike, Yuko Nakano, Yasushi Matsumura, Kazuhiko Nishida, Yoshiki Sawa, Masatsugu Hori, Kinya Otsu
- Journal Title
  
  J. Mol. Cell. Cardiol 46
  
  Pages: 59-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390214
[Journal Article] Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure2008
- Author(s)
  Tetsuya Watanabe, Toshihiro Takeda, Shigemiki Omiya, Shungo Hikoso, Osamu Yamaguchi, Yuko Nakano, Yoshiharu Higuchi, Atsuko Nakai, Yusuke Abe, Yayoi Aki-Jin, PhD, Masayuki Taniike, Isamu Mizote, Yasushi Matsumura, Takahiko Shimizu, Kazuhiko Nishida, Kiyohiro Imai, Masatsugu Hori, Takuji Shirasawa, Kinya Otsu
- Journal Title
  
  J. Am. Coll. Cardiol. 52
  
  Pages: 779-786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390214
[Journal Article] Apoptosis signal-regulating kinase 1(ASK1)/p38 signaling pathway negatively regulates physiological hypertrophy2008
- Author(s)
  Masayuki Taniike, Osamu Yamaguchi, Ikuko Tsujimoto, Shungo Hikoso, Toshihiro Takeda, Atsuko Nakai, Shigemiki Omiya, Isamu Mizote, Yuko Nakano, Yoshiharu Higuchi, Yasushi Matsumura, Kazuhiro Nishida, Masatsugu Hori, Hidenori Ichijo, Kinya Otsu
- Journal Title
  
  Circulation 117
  
  Pages: 545-552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390214
[Journal Article] Progression of heart failure was suppressed by inhibition of apoptosis signal-regulating kinase 1 via transcoronary gene transfer2007
- Author(s)
  Shungo Hikoso, Yasuhiro Ikeda, Osamu Yamaguchi, Toshihiro Takeda, Yoshiharu Higuchi, Shinichi Hirotani, Kazunori Kashiwase, Michio Yamada, Michio Asahi, Yasushi Matsumura, Kazuhiko Nishida, Masunori Matsuzaki, Masatsugu Hori, Kinya Otsu
- Journal Title
  
  J. Am. Coll. Cardiol 50
  
  Pages: 453-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390214
[Journal Article] The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress2007
- Author(s)
  Atsuko Nakai, Osamu Yamaguchi, Toshihiro Takeda, Yoshiharu Higuchi, Shungo Hikoso, Masayuki Taniike, Shigemiki Omiya, Isamu Mizote, Yasushi Matsumura, Michio Asahi, Kazuhiko Nishida, Masatsugu Hori, Noboru Mizushima, Kinya Otsu
- Journal Title
  
  Nature Medicine 13
  
  Pages: 619-624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390214
[Journal Article] The role of apoptosis signal-regulating kinase 1 in cardiomyocyte apoptosis.2006
- Author(s)
  Nishida, Kazuhiko
- Journal Title
  
  Antioxid Redox Signal 8・9-10
  
  Pages: 1729-1736
- Data Source
  KAKENHI-PROJECT-17590732
[Journal Article] The role of apoptosis signal- regulating kinase 1 in cardiomyocyte apoptosis.2006
- Author(s)
  Nishida, Kazuhiko
- Journal Title
  
  Antioxid Redox Signal 8・9-10
  
  Pages: 1729-1736
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590732
[Journal Article] The role of apoptosis signal-regulating kinase 1 in cardiomyocyte apoptosis.2006
- Author(s)
  Nishida, Kazuhiko
- Journal Title
  
  Antioxid Redox Signal 8-9-10
  
  Pages: 1729-1736
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590732
[Journal Article] p38a mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload2004
- Author(s)
  K Nishida他
- Journal Title
  
  Mol.Cell.Biol. 24
  
  Pages: 10611-10620
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590683
[Journal Article] p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertropghic growth in response to pressure overload.2004
- Author(s)
  Nishida K, et al.
- Journal Title
  
  Mol Cell Biol. 24・24
  
  Pages: 10611-10620
- Data Source
  KAKENHI-PROJECT-16590683
[Journal Article] p38a mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.2004
- Author(s)
  Kazuhiko Nishida
- Journal Title
  
  Mol.Cell.Biol. 24
  
  Pages: 10611-10620
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590683

1. OTSU Kinya (20294051)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. HIKOSO Shungo (30423164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YAMAGUCHI Osamu (90467580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. YAMAMOTO Kazuhiro (90303966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 増山理 (70273670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 彦惣俊吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results

NISHIDA Kazuhiko 西田 和彦

Research Projects

Research Products

Co-Researchers

The mechanism of non-apoptotic cardiomyocyte cell deathPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of molecular mechanisms underlying cell death in heart failure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of cardioprotective molecular mechanism via p38MAPK and new therapy for heart failurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of a role of ASK1 in the pathogenesis of heart failure and its application to therapeutics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

心筋及び時間息異的p38α改変マウスによる心肥大から心不全への適応破綻機序の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Calpain protects the heart from hemodynamic stress2011

Author(s)

Journal Title

Data Source

[Journal Article] Activation of MTK1/ MEKK4 induces cardiomyocyte death and heart failure2010

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of autophagy in the heart induces age-related cardiomyopathy2010

Author(s)

Journal Title

Data Source

[Journal Article] The IkappaB kinase beta/ nuclear factor kappaB signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression2009

Author(s)

Journal Title

Data Source

[Journal Article] Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes2009

Author(s)

Journal Title

Data Source

[Journal Article] Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure2008

Author(s)

Journal Title

Data Source

[Journal Article] Apoptosis signal-regulating kinase 1(ASK1)/p38 signaling pathway negatively regulates physiological hypertrophy2008

Author(s)

Journal Title

Data Source

[Journal Article] Progression of heart failure was suppressed by inhibition of apoptosis signal-regulating kinase 1 via transcoronary gene transfer2007

Author(s)

Journal Title

Data Source

[Journal Article] The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress2007

Author(s)

Journal Title

Data Source

[Journal Article] The role of apoptosis signal-regulating kinase 1 in cardiomyocyte apoptosis.2006

Author(s)

Journal Title

Data Source

[Journal Article] The role of apoptosis signal- regulating kinase 1 in cardiomyocyte apoptosis.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] The role of apoptosis signal-regulating kinase 1 in cardiomyocyte apoptosis.2006

NISHIDA Kazuhiko 西田和彦