MATOBA Yasuyuki 的場康幸

… Alternative Names

Matoba Yasuyuki 的場康幸

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Researcher Number	90363051
Affiliation (Current)	2025: 安田女子大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2022: 安田女子大学, 薬学部, 准教授 2017: 広島大学, 医歯薬保健学研究科(薬), 准教授 2013 – 2016: 広島大学, 医歯薬保健学研究院(薬), 准教授 2012: 広島大学, 医歯薬保健学研究院, 准教授 2012: 広島大学, 大学院・医歯薬保健学研究院, 准教授 … More 2007 – 2009: Hiroshima University, 大学院・医歯薬学総合研究科, 准教授 2006: 広島大学, 大学院・医歯薬学総合研究科, 助教授 2005 – 2006: 広島大学, 大学院医歯薬学総合研究科, 助教授 2004: 広島大学, 大学院・医歯薬学総合研究科, 助手 Less
Review Section/Research Field	Principal Investigator Science and Engineering / Basic Section 37010:Bio-related chemistry / Natural medicines / Physical pharmacy / Biological pharmacy / Drug development chemistry Except Principal Investigator Chemistry related to living body / Physical pharmacy
Keywords	Principal Investigator X線結晶構造解析 / チロシナーゼ / 構造生物学 / 銅 / 金属シャペロン / 反応機構 / 共鳴ラマンスペクトル / ラマンスペクトル / 結晶構造解析 / 酵素 … More / 抗生物質 / 阻害剤 / 成熟化 / 銅イオン / 変異体 / D-サイクロセリン / ヘムタンパク質 / 光学分割 / 非天然型アミノ酸 / 微生物薬品学 / ドラッグデザイン / 構造生物 / 医療応用 / ブレオマイシン / シャペロン / 創薬 … More Except Principal Investigator X線結晶構造解析 / 吸収スペクトル / ラマンスペクトル / タンパク質 / 放線菌 / メラニン生成酵素 / 金属シャペロン / 銅イオン / X 線結晶構造解析 / チロシナーゼ / 核酸・タンパク質複合体 / Streptomyces albus / タンパク質・核酸複合体 / 結晶化 / リプレッサー / サーモセンシング Less

Elucidation of catalytic and maturation mechanisms of dicopper enzyme tyrosinase and the development of the inhibitorsPrincipal Investigator
- Principal Investigator
  
  Matoba Yasuyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Yasuda Women's University
Generation of unnatural amino acids using enzymes for the biosynthesis of antitubercular antibiotic D-cycloserinePrincipal Investigator
- Principal Investigator
  
  Matoba Yasuyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Natural medicines
- Research Institution
  Hiroshima University
時間分割解析を用いた二核銅酵素チロシナーゼの反応機構の解明Principal Investigator
- Principal Investigator
  
  的場康幸
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Hiroshima University
銅輸送タンパク質キャディーを用いたチロシナーゼ反応機構の解明Principal Investigator
- Principal Investigator
  
  的場康幸
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Hiroshima University
A molecular mechanism for copper transportation to tyrosinase that is assisted by a metallochaperone, caddie protein
- Principal Investigator
  
  SUGIYAMA Masanori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Hiroshima University
Structural study of D-Ala-D-Ala ligase to develop new antibioticsPrincipal Investigator
- Principal Investigator
  
  MATOBA Yasuyuki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hiroshima University
構造生物学的知見に基づいた耐熱性ブレオマイシンアセチル化酵素の創生と医療応用Principal Investigator
- Principal Investigator
  
  的場康幸
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hiroshima University
サーモセンシングタンパク質の立体構造解析と医療への応用
- Principal Investigator
  
  SUGIYAMA Masanori
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hiroshima University
分子シャペロンによるチロシナーゼ活性化の構造生物学的解析とコスメトロジーへの応用Principal Investigator
- Principal Investigator
  
  的場康幸
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hiroshima University

[Book] Microbial Production: From Genome Design to Cell Engineering2014
- Author(s)
  Matoba Y, Sugiyama M
- Total Pages
  8
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PUBLICLY-25109530
[Book] シーエムシー出版2012
- Author(s)
  的場康幸、杉山政則
- Total Pages
  8
- Publisher
  チロシナーゼの三次元構造と酒粕由来のチロシナーゼ阻害剤
- Data Source
  KAKENHI-PROJECT-22550153
[Book] チロシナーゼの三次元構造と酒粕由来のチロシナーゼ阻害剤2011
- Author(s)
  的場康幸, 杉山政則
- Publisher
  シーエムシー
- Data Source
  KAKENHI-PROJECT-22550153
[Journal Article] Catalytic mechanism of DcsB: Arginase framework used for hydrolyzing its inhibitor2022
- Author(s)
  Oda Kosuke, Sakaguchi Takemasa, Matoba Yasuyuki
- Journal Title
  
  Protein Science
  
  Volume: 31 Issue: 6
- DOI
  10.1002/pro.4338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05715, KAKENHI-PROJECT-20K06507
[Journal Article] チロシナーゼの反応機構解明を目指して2022
- Author(s)
  的場　康幸
- Journal Title
  
  COSMETOLOGY
  
  Volume: 30 Pages: 239-239
- Data Source
  KAKENHI-PROJECT-20K05715
[Journal Article] X線結晶構造解析に基づくチロシナーゼの成熟化および反応機構の解析2022
- Author(s)
  的場　康幸
- Journal Title
  
  COSMETOLOGY
  
  Volume: 30 Pages: 147-150
- Data Source
  KAKENHI-PROJECT-20K05715
[Journal Article] Crystal structure of O‐ureidoserine racemase found in the D‐cycloserine biosynthetic pathway2022
- Author(s)
  Oda Kosuke、Sakaguchi Takemasa、Matoba Yasuyuki
- Journal Title
  
  Proteins: Structure, Function, and Bioinformatics
  
  Volume: 90 Issue: 4 Pages: 912-918
- DOI
  10.1002/prot.26290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06507, KAKENHI-PROJECT-20K05715
[Journal Article] The basicity of an active-site water molecule discriminates between tyrosinase and catechol oxidase activity.2021
- Author(s)
  Yasuyuki Matoba, Kosuke Oda, Yoshimi Muraki, Taro Masuda
- Journal Title
  
  International Journal of Biological Macromolecules
  
  Volume: 183 Pages: 1861-1870
- DOI
  10.1016/j.ijbiomac.2021.05.206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06221, KAKENHI-PROJECT-20K05715, KAKENHI-PROJECT-20K06507
[Journal Article] Lectins engineered to favor a glycan-binding conformation have enhanced antiviral activity2021
- Author(s)
  Matoba Yasuyuki、Sato Yuichiro、Oda Kosuke、Hatori Yuta、Morimoto Kinjiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: - Pages: 100698-100698
- DOI
  10.1016/j.jbc.2021.100698
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05715, KAKENHI-PROJECT-20K06507
[Journal Article] Structural Insight into the Interaction of Sendai Virus C Protein with Alix To Stimulate Viral Budding2021
- Author(s)
  Oda Kosuke、Matoba Yasuyuki、Sugiyama Masanori、Sakaguchi Takemasa
- Journal Title
  
  Journal of Virology
  
  Volume: 95 Issue: 19
- DOI
  10.1128/jvi.00815-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05715, KAKENHI-PROJECT-20K06507
[Journal Article] Crystal structure of an Nω-hydroxy-L-arginine hydrolase found in the D-cycloserine biosynthetic pathway2020
- Author(s)
  Oda Kosuke、Shimotani Natsuki、Kuroda Teruo、Matoba Yasuyuki
- Journal Title
  
  Acta Crystallographica Section D Structural Biology
  
  Volume: 76 Issue: 6 Pages: 506-514
- DOI
  10.1107/s2059798320004908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05715, KAKENHI-PROJECT-20K06507
[Journal Article] Catalytic specificity of the Lactobacillus plantarum cystathionine γ-lyase presumed by the crystallographic analysis2020
- Author(s)
  Matoba Yasuyuki、Noda Masafumi、Yoshida Tomoki、Oda Kosuke、Ezumi Yuka、Yasutake Chiaki、Izuhara-Kihara Hisae、Danshiitsoodol Narandarai、Kumagai Takanori、Sugiyama Masanori
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 14886-14886
- DOI
  10.1038/s41598-020-71756-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05715, KAKENHI-PROJECT-20K06507
[Journal Article] Expression of Genes Involved in Bacteriocin Production and Self-Resistance in Lactobacillus brevis 174A Is Mediated by Two Regulatory Proteins.2018
- Author(s)
  Noda M, Miyauchi R, Danshiitsoodol N, Matoba Y, Kumagai T, Sugiyama M.
- Journal Title
  
  Appl. Environ. Microbiol.
  
  Volume: 84 Issue: 7
- DOI
  10.1128/aem.02707-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08294, KAKENHI-PROJECT-17K08334, KAKENHI-PROJECT-17K08335, KAKENHI-PROJECT-15K07997
[Journal Article] Two types of phenoloxidases contribute to hemolymph PO activity in spiny Lobster.2018
- Author(s)
  Taro Masuda*, Tatsuki Kawauchi, Yuya Yata, Yasuyuki Matoba, Haruhiko Toyohara
- Journal Title
  
  Food Chemistry
  
  Volume: 260 Pages: 166-173
- DOI
  10.1016/j.foodchem.2018.03.110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07574, KAKENHI-PROJECT-15K07997
[Journal Article] Activation mechanism of the Streptomyces tyrosinase assisted by the caddie protein2017
- Author(s)
  Matoba Y, Kihara S, Muraki Y, Bando N, Yoshitsu H, Kuroda T, Sakaguchi M, Kayama K, Tai H, Hirota S, Ogura T, Sugiyama M
- Journal Title
  
  Biochemistry
  
  Volume: 56 Issue: 41 Pages: 5593-5603
- DOI
  10.1021/acs.biochem.7b00635
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07997
[Journal Article] Crystallographic and Mutational Analyses of Cystathionine β-Synthase in the H2S-synthetic Gene Cluster in Lactobacillus plantarum2017
- Author(s)
  Y Matoba, T Yoshida, H Izuhara-Kihara, M Noda, M Sugiyama
- Journal Title
  
  Protein Sci.
  
  Volume: 26 Issue: 4 Pages: 763-783
- DOI
  10.1002/pro.3123
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H00947, KAKENHI-PROJECT-15K07997
[Journal Article] Structural analysis of the STAT1:STAT2 heterodimer revealed the mechanism of Sendai virus C protein-mediated blockade of type 1 interferon signaling2017
- Author(s)
  Oda Kosuke、Oda Takashi、Matoba Yasuyuki、Sato Mamoru、Irie Takashi、Sakaguchi Takemasa
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 48 Pages: 19752-19766
- DOI
  10.1074/jbc.m117.786285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19560, KAKENHI-PROJECT-15K07997, KAKENHI-PROJECT-16K19140, KAKENHI-PROJECT-16H05197
[Journal Article] Anti-Obesity Effect of Pediococcus pentosaceus LP28 on Overweight Subjects: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial2016
- Author(s)
  F Higashikawa, M Noda, T Awaya, N Danshiitsoodol, Y Matoba, T Kumagai, M Sugiyama
- Journal Title
  
  Eur. J. Clin. Nutr.
  
  Volume: 70 Issue: 5 Pages: 582-587
- DOI
  10.1038/ejcn.2016.17
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H00947, KAKENHI-PROJECT-15K07997
[Journal Article] 非天然型アミノ酸D-サイクロセリン生合成酵素の結晶構造2016
- Author(s)
  的場康幸
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 74 Pages: 510-513
- NAID
  40021006497
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H00947
[Journal Article] 非天然型アミノ酸D-サイクロセリン生合成酵素の結晶構造2016
- Author(s)
  的場康幸
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 74 Pages: 510-513
- NAID
  40021006497
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07997
[Journal Article] High level heterologous production of D-cycloserine by Escherichia coli2015
- Author(s)
  Kumagai T, Ozawa T, Tanimoto M, Noda M, Matoba Y, Sugiyama M.
- Journal Title
  
  Appl. Environ. Microbiol.
  
  Volume: 81 Issue: 22 Pages: 7881-7887
- DOI
  10.1128/aem.02187-15
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07997, KAKENHI-PUBLICLY-15H00947, KAKENHI-PROJECT-25460119
[Journal Article] The structural and mutational analyses of O-ureido-L-serine synthase necessary for D-cycloserine biosynthesis2015
- Author(s)
  Uda N, Matoba Y, Oda K, Kumagai T, Sugiyama M.
- Journal Title
  
  FEBS J.
  
  Volume: 282 Issue: 20 Pages: 3929-3944
- DOI
  10.1111/febs.13386
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07997, KAKENHI-PUBLICLY-15H00947, KAKENHI-PROJECT-25460119
[Journal Article] Structural basis of the inhibition of STAT1 activity by Sendai virus C protein2015
- Author(s)
  Oda K, Matoba Y, Irie T, Kawabata R, Fukushi M, Sugiyama M, Sakaguchi T.
- Journal Title
  
  J. Virol.
  
  Volume: 89 Issue: 22 Pages: 11487-11499
- DOI
  10.1128/jvi.01887-15
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07997, KAKENHI-PUBLICLY-15H00947, KAKENHI-PROJECT-25460569
[Journal Article] D-サイクロセリン生合成機構の解明と非天然型アミノ酸合成への応用2014
- Author(s)
  的場　康幸
- Journal Title
  
  Institute for Fermentation, Osaka, Research Communications
  
  Volume: 28 Pages: 134-134
- Data Source
  KAKENHI-PUBLICLY-25109530
[Journal Article] An alternative allosteric regulation mechanism of an acidophilic L-lactate dehydrogenase from Enterococcus mundtii 15-1A2014
- Author(s)
  Y. Matoba, M. Miyasako, K. Matsuo, Kosuke Oda, M. Noda, F. Higashikawa, T. Kumagai, M. Sugiyama
- Journal Title
  
  FEBS Open Bio.
  
  Volume: 4 Issue: 1 Pages: 834-847
- DOI
  10.1016/j.fob.2014.08.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23687020, KAKENHI-PUBLICLY-25109530, KAKENHI-PROJECT-25460119, KAKENHI-PROJECT-25860341
[Journal Article] Establishment of an in vitroD-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway2013
- Author(s)
  Uda, N., Matoba, Y., Kumagai, T., Oda, K., Noda, M., and Sugiyama, M
- Journal Title
  
  Antimicrob. Agents Chemother
  
  Volume: 57 Issue: 6 Pages: 2603-2612
- DOI
  10.1128/aac.02291-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790068, KAKENHI-PUBLICLY-25109530, KAKENHI-PROJECT-25460119
[Journal Article] Crystallographic study to determine the substrate specificity on an L-serine-acetylating enzyme found in the D-cycloserine biosynthetic pathway2013
- Author(s)
  Oda, K., Matoba, Y., Kumagai, T., Noda, M., and Sugiyama, M
- Journal Title
  
  J. Bacteriol
  
  Volume: 195 Issue: 8 Pages: 1741-1749
- DOI
  10.1128/jb.02085-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790068, KAKENHI-PUBLICLY-25109530, KAKENHI-PROJECT-25460119
[Journal Article] Crystallographic and mutational analyses of tannase from Lactobacillus plantarum.2013
- Author(s)
  Matoba Y, Tanaka N, Noda M, Higashikawa F, Kumagai T, Sugiyama M.
- Journal Title
  
  Proteins
  
  Volume: 81 Issue: 11 Pages: 2052-2058
- DOI
  10.1002/prot.24355
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25109530
[Journal Article] メラニン生成酵素の三次元構造を美白化粧品開発に活かす2011
- Author(s)
  的場康幸, 杉山政則
- Journal Title
  
  COSME TECH JAPAN
  
  Volume: 1 Pages: 717-722
- Data Source
  KAKENHI-PROJECT-22550153
[Journal Article] A molecular mechanism for copper transportation to tyrosinase that is assisted by a metallochaperone, caddie protein2011
- Author(s)
  Matoba Y, Bando N, Oda K, Noda M, Higashikawa F, Kumagai T, Sugiyama M
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Pages: 30219-30231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22550153
[Journal Article] Molecular cloning and heterologous expression of a biosynthetic gene cluster for an anti-tubercular agent D-cycloserine produced by Streptomyces lavendulae2010
- Author(s)
  Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
- Journal Title
  
  Antimicrobiol. Agents Chemother 54
  
  Pages: 1132-1139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790035
[Journal Article] Catalytic mechanism of bleomycin-N-acetyltransferase proposed on the base of its crystal structure2010
- Author(s)
  Oda K, Matoba Y, Noda M, Kumagai T, Sugiyama M
- Journal Title
  
  J. Biol. Chem 285
  
  Pages: 1446-1456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790035
[Journal Article] A novel tyrosine- phosphorylated protein inhibiting the growth of Streptomyces cells2009
- Author(s)
  Kumagai T, Kihara H, Watanabe W, Noda M, Matoba Y, Sugiyama M
- Journal Title
  
  Biochem. Biophys. Res. Commun 385
  
  Pages: 534-538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790035
[Journal Article] Crystallographic evidence that dinuclear copper center of tyrosinase is flexible during catalysis2006
- Author(s)
  Matoba Y, Kumagai T, Yamamoto A, Yoshitsu H, Sugiyama M.
- Journal Title
  
  Journal of Biological Chemistry (印刷中)
- Data Source
  KAKENHI-PROJECT-16790083
[Journal Article] Crystallographic evidence that the dinuclear copper center of tyrosinase is flexible during catalysis2006
- Author(s)
  Yasuyuki Matoba
- Journal Title
  
  The Journal of Biological Chemistry 281・13
  
  Pages: 8981-8990
- Data Source
  KAKENHI-PROJECT-17659012
[Journal Article] A novel assay method for an amino acid racemase reaction based on circular dichroism.2005
- Author(s)
  Noda M, Matoba Y, Kumagai T, Sugiyama M.
- Journal Title
  
  Biochemical Journal (印刷中)
- Data Source
  KAKENHI-PROJECT-16790083
[Journal Article] A novel assay method for an amino acid racemase reaction based on circular dichroism.2005
- Author(s)
  Noda M, Matoba Y, Kumagai T, Sugiyama M.
- Journal Title
  
  Biochemical Journal 389・2
  
  Pages: 491-496
- Data Source
  KAKENHI-PROJECT-16790083
[Journal Article] Self-protection mechanism in D-cycloserine-producing Streptomyces lavendulae. Gene cloning, characterization, and kinetics of its alanine racemase and D-alanyl-D-alanine ligase, which are target enzymes of D-cycloserine.2004
- Author(s)
  Noda M, Kawahara Y, Ichikawa A, Matoba Y, Matsuo H, Lee DG, Kumagai T, Sugiyama M.
- Journal Title
  
  Journal of Biologics Chemistry 279(44)
  
  Pages: 46143-46152
- Data Source
  KAKENHI-PROJECT-16790083
[Journal Article] Structural evidence that alanine racemase from a D-cycloserine-producing microorganism exhibits resistance to its own product.2004
- Author(s)
  Noda M, Matoba Y, Kumagai T, Sugiyama M.
- Journal Title
  
  Journal of Biological Chemistry 279(44)
  
  Pages: 46153-46161
- Data Source
  KAKENHI-PROJECT-16790083
[Presentation] Elucidation of Catalytic Mechanism of Tyrosinase by Using Time-Resolved Analysis2017
- Author(s)
  Yasuyuki Matoba
- Organizer
  感応性化学種が拓く新物質科学第2回国際シンポジウム
- Place of Presentation
  広島大学　学士会館　レセプションホール
- Year and Date
  2017-03-06
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H00947
[Presentation] Catalytic mechanism of a heme-binding arginine hydroxylase responsible for the biosynthesis of D-cycloserine2017
- Author(s)
  Shimotani N, Furukawa Y, Uda N, Kuroda T, Yanagisawa S, Ogura T, Mizohata E, Inoue T, Kamachi T, Yoshizawa K, Matoba Y
- Organizer
  第27回金属の関与する生体関連反応シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07997
[Presentation] 細菌由来シスタチオニンβ-シンターゼの性質と構造、および、その阻害剤開発2017
- Author(s)
  安武千晶, 吉田智喜、伊豆原-木原久枝, 黒田照夫, 杉山政則, 的場康幸
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター展示棟
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PUBLICLY-15H00947
[Presentation] Elucidation of Catalytic Mechanism of Tyrosinase by Using Time-Resolved Analysis2017
- Author(s)
  Yasuyuki Matoba
- Organizer
  感応性化学種が拓く新物質科学第2回国際シンポジウム
- Place of Presentation
  広島大学学士会館レセプションホール
- Year and Date
  2017-03-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07997
[Presentation] 細菌由来シスタチオニンβ-シンターゼの性質と構造、および、その阻害剤開発2017
- Author(s)
  安武千晶, 吉田智喜、伊豆原-木原久枝, 黒田照夫, 杉山政則, 的場康幸
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-15K07997
[Presentation] D-サイクロセリン生合成に関わる新規ヘムタンパク質DcsAの構造と性質2016
- Author(s)
  的場康幸, 古川裕貴, 柳澤幸子, 宇田成利, 熊谷孝則, 小倉尚志, 杉山政則
- Organizer
  第68回日本生物工学会大会
- Place of Presentation
  富山国際会議場
- Year and Date
  2016-09-28
- Data Source
  KAKENHI-PROJECT-15K07997
[Presentation] Crystallographic and spectroscopic studies of DcsA, a heme-binding arginine hydroxylase responsible for the biosynthesis of D-cycloserine2016
- Author(s)
  Yasuyuki Matoba
- Organizer
  感応性化学種が拓く新物質科学第4回若手国際シンポジウム
- Place of Presentation
  大阪大学工学研究科サントリーメモリアルホール
- Year and Date
  2016-12-12
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H00947
[Presentation] 時間分割解析を用いた二核銅酵素チロシナーゼの反応機構の解明2016
- Author(s)
  的場康幸
- Organizer
  感応性化学種が拓く新物質化学　第6回公開シンポジウム
- Place of Presentation
  広島大学　学士会館　レセプションホール
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PUBLICLY-15H00947
[Presentation] D-サイクロセリン合成酵素DcsGの構造生物学的研究およびホモシステインの定量と光学分割への応用2016
- Author(s)
  工藤真子, 的場康幸, 宇田成利, 熊谷孝則, 黒田照夫, 杉山政則
- Organizer
  第55回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  就実大学
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-15K07997
[Presentation] D-サイクロセリン生合成に関わる新規ヘムタンパク質DcsAの構造と性質2016
- Author(s)
  的場康幸, 古川裕貴, 柳澤幸子, 宇田成利, 熊谷孝則, 小倉尚志, 杉山政則
- Organizer
  第68回日本生物工学会大会
- Place of Presentation
  富山国際会議場
- Year and Date
  2016-09-28
- Data Source
  KAKENHI-PUBLICLY-15H00947
[Presentation] 時間分割解析を用いた二核銅酵素チロシナーゼの反応機構の解明2016
- Author(s)
  的場康幸
- Organizer
  感応性化学種が拓く新物質化学第6回公開シンポジウム
- Place of Presentation
  広島大学学士会館レセプションホール
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-15K07997
[Presentation] D-サイクロセリン合成酵素DcsGの構造生物学的研究およびホモシステインの定量と光学分割への応用2016
- Author(s)
  工藤真子, 的場康幸, 宇田成利, 熊谷孝則, 黒田照夫, 杉山政則
- Organizer
  第55回日本薬学会・日本薬剤師会・日本病院薬剤師会　中国四国支部学術大会
- Place of Presentation
  就実大学
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PUBLICLY-15H00947
[Presentation] Crystallographic and spectroscopic studies of DcsA, a heme-binding arginine hydroxylase responsible for the biosynthesis of D-cycloserine2016
- Author(s)
  Yasuyuki Matoba
- Organizer
  感応性化学種が拓く新物質科学第4回若手国際シンポジウム
- Place of Presentation
  大阪大学工学研究科サントリーメモリアルホール
- Year and Date
  2016-12-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07997
[Presentation] D-サイクロセリン生合成に関わるアルギニンヒドロキシラーゼの構造化学的研究2015
- Author(s)
  古川裕貴，的場康幸，柳澤幸子，宇田成利，工藤真子，熊谷孝則，小倉尚志，杉山政則
- Organizer
  第25回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  長崎大学文教スカイホール
- Year and Date
  2015-05-30
- Data Source
  KAKENHI-PROJECT-15K07997
[Presentation] D-サイクロセリン合成酵素DcsGの構造生物学的研究2015
- Author(s)
  的場康幸, 宇田成利, 熊谷孝則, 杉山政則
- Organizer
  第67回日本生物工学会大会
- Place of Presentation
  城山観光ホテル, 鹿児島市
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-15K07997
[Presentation] Quinone formation on the Tyr98 residue of the caddie protein correlative to the catalytic mechanism of tyrosinase2015
- Author(s)
  Yasuyuki Matoba, Shogo Kihara, Naohiko Bando, Miyuki Sakaguchi, Kuree’ Kayama, Takanori Kumagai, Takashi Ogura, and Masanori Sugiyama
- Organizer
  2015 International Chemical Congress of Pacific Basin Society
- Place of Presentation
  Hawaii Convention Center, Honolulu Hawaii, USA
- Year and Date
  2015-12-10
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H00947
[Presentation] cysJ およびcysK遺伝子の二重破壊大腸菌株の使用によるD-サイクロセリン生産性の向上2015
- Author(s)
  熊谷孝則, 小澤智紀, 的場康幸, 野田正文, 杉山政則
- Organizer
  2015年度日本放線菌学会大会
- Place of Presentation
  富山国際会議場
- Year and Date
  2015-09-07
- Data Source
  KAKENHI-PROJECT-15K07997
[Presentation] チロシナーゼの構造と反応性2015
- Author(s)
  的場康幸
- Organizer
  九州大学先導物質化学研究所吉澤研究室セミナー
- Place of Presentation
  九州大学先導物質化学研究所
- Year and Date
  2015-06-04
- Data Source
  KAKENHI-PUBLICLY-15H00947
[Presentation] D-サイクロセリン生合成に関わるアルギニン水酸化酵素の構造と性質2015
- Author(s)
  古川裕貴，的場康幸，柳澤幸子，宇田成利，工藤真子，熊谷孝則，小倉尚志，杉山政則
- Organizer
  第9回バイオ関連化学シンポジウム
- Place of Presentation
  熊本大学工学部・黒髪南地区キャンパス
- Year and Date
  2015-09-10
- Data Source
  KAKENHI-PROJECT-15K07997
[Presentation] D-サイクロセリン生合成に関わるアルギニンヒドロキシラーゼ2015
- Author(s)
  古川裕貴，的場康幸，柳澤幸子，宇田成利，工藤真子，熊谷孝則，小倉尚志，杉山政則
- Organizer
  第48回酸化反応討論会
- Place of Presentation
  同志社大学寒梅館, 京都市
- Year and Date
  2015-10-23
- Data Source
  KAKENHI-PROJECT-15K07997
[Presentation] D-サイクロセリン生合成機構の解明と非天然型アミノ酸合成への応用2014
- Author(s)
  的場　康幸
- Organizer
  公益財団法人発酵研究所　第8回助成研究報告会
- Place of Presentation
  大阪府豊中市千里ライフサイエンスセンター
- Year and Date
  2014-06-05
- Data Source
  KAKENHI-PUBLICLY-25109530
[Presentation] Production of the unnatural and optically active amino acids using the enzymes found in the D-cycloserine biosynthetic pathway2014
- Author(s)
  的場康幸
- Organizer
  ノボザイムズバイオフォーラム2014
- Place of Presentation
  千葉市　クロスウェーブ幕張
- Year and Date
  2014-10-24
- Invited
- Data Source
  KAKENHI-PUBLICLY-25109530
[Presentation] 二核銅酵素チロシナーゼの構造化学的研究と無機触媒開発への期待2014
- Author(s)
  的場　康幸
- Organizer
  第5回次世代材料・テクノロジー研究会
- Place of Presentation
  名古屋工業大学2号館
- Year and Date
  2014-07-09
- Invited
- Data Source
  KAKENHI-PUBLICLY-25109530
[Presentation] 二核銅酵素チロシナーゼの構造生物化学的研究2014
- Author(s)
  的場　康幸
- Organizer
  大阪大学理学部舩橋研究室セミナー
- Place of Presentation
  大阪大学理学部
- Year and Date
  2014-07-30
- Invited
- Data Source
  KAKENHI-PUBLICLY-25109530
[Presentation] センダイウイルスCタンパク質と宿主転写因子STAT1の複合体構造2013
- Author(s)
  小田康祐, 的場康幸, 江田優子, 川端涼子, 入江崇, 福士雅也, 坂口剛正
- Organizer
  第36回（2013年）日本分子生物学会
- Place of Presentation
  神戸ポートピアホテル
- Data Source
  KAKENHI-PUBLICLY-25109530
[Presentation] X線結晶構造に基づいたD-サイクロセリン合成酵素DcsGの触媒機構の解明2013
- Author(s)
  宇田成利, 的場康幸, 小田康祐, 熊谷孝則, 野田正文, 杉山政則
- Organizer
  2013年度(第28回)日本放線菌学会大会
- Place of Presentation
  メルパルク広島
- Data Source
  KAKENHI-PUBLICLY-25109530
[Presentation] Lactobacillus plantarumタンナーゼのX線結晶構造2013
- Author(s)
  田中尚美, 的場康幸, 野田正文, 熊谷孝則, 杉山政則
- Organizer
  日本乳酸菌学会2013年度大会
- Place of Presentation
  北海道大学学術交流会館
- Data Source
  KAKENHI-PUBLICLY-25109530
[Presentation] 自然免疫の抑制に関わるセンダイウイルスCタンパク質と宿主転写因子STAT1の構造生物学的解析2013
- Author(s)
  小田康祐, 的場康幸, 川端凉子, 入江崇, 福士雅也, 坂口剛正
- Organizer
  第61回日本ウィルス学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PUBLICLY-25109530
[Presentation] ロイシルブラストサイジンSを脱アミノアシル化する酵素の同定2013
- Author(s)
  桑田祥, 的場康幸, 小田康祐, 野田正文, 熊谷孝則, 杉山政則
- Organizer
  2013年度(第65回)日本生物工学会大会
- Place of Presentation
  広島国際会議場
- Data Source
  KAKENHI-PUBLICLY-25109530
[Presentation] O-ウレイド-L-セリン合成酵素DcsDの活性発現に重要なアミノ酸残基の特定2013
- Author(s)
  宇田成利, 的場康幸, 小田康祐, 熊谷孝則, 野田正文, 杉山政則
- Organizer
  2013年度(第65回)日本生物工学会大会
- Place of Presentation
  広島国際会議場
- Data Source
  KAKENHI-PUBLICLY-25109530
[Presentation] チロシナーゼの構造化学的研究2012
- Author(s)
  的場康幸
- Organizer
  兵庫県立大学・理学部セミナー
- Place of Presentation
  兵庫県立大学・理学部
- Year and Date
  2012-07-18
- Data Source
  KAKENHI-PROJECT-22550153
[Presentation] キャディーによるチロシナーゼへの銅輸送の分子機構2012
- Author(s)
  的場康幸ら
- Organizer
  21012年度（第27回）日本放線菌学会大会
- Place of Presentation
  府中の森芸術劇場(東京都府中市)
- Data Source
  KAKENHI-PROJECT-22550153
[Presentation] キャディーによるチロシナーゼへの銅輸送機構2012
- Author(s)
  的場康幸, 坂東尚彦, 小田康祐, 野田正文, 東川史子, 熊谷孝則, 杉山政則
- Organizer
  第5回バイオ関連化学シンポジウム
- Place of Presentation
  つくば国際会議場
- Year and Date
  2012-09-14
- Data Source
  KAKENHI-PROJECT-22550153
[Presentation] キャディーによるチロシナーゼへの銅輸送の分子機構2012
- Author(s)
  的場康幸, 坂東尚彦, 小田康祐, 野田正文, 東川史子, 熊谷孝則, 杉山政則
- Organizer
  日本放線菌学会大会
- Place of Presentation
  府中の森芸術劇場, 東京都府中市
- Year and Date
  2012-09-07
- Data Source
  KAKENHI-PROJECT-22550153
[Presentation] チロシナーゼの三次元構造と酒粕由来のチロシナーゼ阻害剤2011
- Author(s)
  的場康幸
- Organizer
  未来へのバイオ技術勉強会月例会
- Place of Presentation
  バイオインダストリー協会第1会議室, 東京
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22550153
[Presentation] キャディーによるチロシナーゼへの銅輸送機構2011
- Author(s)
  的場康幸, ら
- Organizer
  第5回バイオ関連化学シンポジウム
- Place of Presentation
  つくば国際会議場
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-22550153
[Presentation] D-サイクロセリン生合成遺伝子クラスターのクローニングと機能解析2010
- Author(s)
  小山佑介, 熊谷孝則, 野田正文, 的場康幸, 杉山政則
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20790035
[Presentation] D-サイクロセリン生合成に関与する4種類のタンパク質DcsB, DcsC, DcsDおよびDcsGの機能解析2010
- Author(s)
  宇田成利, 的場康幸, 小田康祐, 野田正文, 熊谷孝則, 杉山政則
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20790035
[Presentation] 放線菌Streptomyces coelicolorに存在するチロシンリン酸化タンパク質の同定と機能解析2010
- Author(s)
  熊谷孝則, 木原春日, 渡邉稚子, 野田正文, 的場康幸, 杉山政則
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20790035
[Presentation] D-サイクロセリン生合成に関与する酵素セリンO-アセチルトランスフェラーゼの構造生物学的研究2010
- Author(s)
  小田康祐, 的場康幸, 野田正文, 熊谷孝則, 杉山政則
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20790035
[Presentation] D-サイクロセリン生合成に関与するセリンO-アセチルトランスフェラーゼの構造解析2009
- Author(s)
  小田康祐, 的場康幸, 野田正文, 熊谷孝則, 杉山政則
- Organizer
  第61回日本生物工学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20790035
[Presentation] 構造学的知見に基づいたブレオマイシンN-アセチルトランスフェラーゼの反応機構の解明2008
- Author(s)
  小田康祐, 的場康幸, 野田孝則, 杉山政則
- Organizer
  平成20年度日本蛋白質科学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790035
[Presentation] Streptomyces verticillusの自己耐性因子ブレオマイシンN-アセチル化酵素の反応機構と基質阻害機構の解明2008
- Author(s)
  小田康祐, 的場康幸, 野田正文, 熊孝則, 杉山政則
- Organizer
  2008年度日本放線菌学会大会
- Place of Presentation
  山梨
- Data Source
  KAKENHI-PROJECT-20790035
[Presentation] チロシナーゼの構造化学的研究
- Author(s)
  的場康幸
- Organizer
  兵庫県立大学　理学部セミナー
- Place of Presentation
  兵庫県立大学理学部
- Invited
- Data Source
  KAKENHI-PROJECT-22550153
[Presentation] 放線菌チロシナーゼの成熟化と反応機構
- Author(s)
  的場　康幸
- Organizer
  第27回生物無機化学夏季セミナー
- Place of Presentation
  兵庫県姫路市書写山円教寺
- Year and Date
  2014-08-29 – 2014-08-31
- Invited
- Data Source
  KAKENHI-PUBLICLY-25109530
[Presentation] XFEL連続フェムト秒結晶構造解析：構造生物学の新時代
- Author(s)
  溝端栄一、福田庸太、鈴木守、南後恵理子、菅原道泰、矢橋牧名、登野健介、城地保昌、島村達郎、潘東青、シャバスレオナルド、西澤知宏、松村浩由、林高史、的場康幸、杉山成、村田道雄、高木淳一、井上豪、岩田想
- Organizer
  第14回日本タンパク質科学会年会
- Place of Presentation
  ワークピア横浜/横浜産貿ホール　マリネリア
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PUBLICLY-25109530

1. SUGIYAMA Masanori (30106801)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. 熊谷孝則 (70274058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. NODA Masafumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. SUGAWARA Tatsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 松尾光一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 坂口剛正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 入江崇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 小田康祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 小田隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MATOBA Yasuyuki 的場 康幸

Matoba Yasuyuki 的場 康幸

Research Projects

Research Products

Co-Researchers

Elucidation of catalytic and maturation mechanisms of dicopper enzyme tyrosinase and the development of the inhibitorsPrincipal Investigator

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Generation of unnatural amino acids using enzymes for the biosynthesis of antitubercular antibiotic D-cycloserinePrincipal Investigator

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時間分割解析を用いた二核銅酵素チロシナーゼの反応機構の解明Principal Investigator

Principal Investigator

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銅輸送タンパク質キャディーを用いたチロシナーゼ反応機構の解明Principal Investigator

Principal Investigator

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A molecular mechanism for copper transportation to tyrosinase that is assisted by a metallochaperone, caddie protein

Principal Investigator

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Structural study of D-Ala-D-Ala ligase to develop new antibioticsPrincipal Investigator

Principal Investigator

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構造生物学的知見に基づいた耐熱性ブレオマイシンアセチル化酵素の創生と医療応用Principal Investigator

Principal Investigator

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サーモセンシングタンパク質の立体構造解析と医療への応用

Principal Investigator

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分子シャペロンによるチロシナーゼ活性化の構造生物学的解析とコスメトロジーへの応用Principal Investigator

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[Book] Microbial Production: From Genome Design to Cell Engineering2014

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[Book] シーエムシー出版2012

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[Book] チロシナーゼの三次元構造と酒粕由来のチロシナーゼ阻害剤2011

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[Journal Article] Catalytic mechanism of DcsB: Arginase framework used for hydrolyzing its inhibitor2022

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[Journal Article] チロシナーゼの反応機構解明を目指して2022

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MATOBA Yasuyuki 的場康幸

Matoba Yasuyuki 的場康幸