Mihara Keichiro 三原圭一朗

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MIHARA Keichiro 三原圭一朗

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Researcher Number	90363077
Other IDs
Affiliation (Current)	2025: 藤田医科大学, 国際再生医療センター, 教授
Affiliation (based on the past Project Information) *help	2020 – 2025: 藤田医科大学, 国際再生医療センター, 教授 2019: 広島大学, 病院(医), 講師 2008 – 2010: Hiroshima University, 原爆放射線医科学研究所, 助教 2009: 広島大学, 原爆放射線医学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 54010:Hematology and medical oncology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 49030:Experimental pathology-related / Basic Section 42040:Laboratory animal science-related / Hematology
Keywords	Principal Investigator CAR-T細胞療法 / iPS-T細胞 / 骨髄腫 / CAR-T / survivin / MDR / Survivin / BMI-1 Except Principal Investigator CAR-T / 小児がん … More / NK細胞受容体 / CAR-T細胞 / NK細胞 / キメラ抗原受容体 / ワクチンブースティング / 二重抗原特異性 / 抗原受容体遺伝子改変T細胞 / macrophage / CAR / CD47 / CD24 / 骨軟部腫瘍 / 大腸がん / 膵がん / 横紋筋肉腫 / 骨肉腫 / Meflin / がん関連線維芽細胞 / 間葉系幹細胞 / 脳腫瘍 / 肉腫 / メモリー様NK細胞 / CAR-NK細胞 / NKp44 / 金属輸送 / 同所移植動物モデル / 癌治療法 / 分子標的 / 臨床検体 / バイオインフォマティクス / 遺伝子解析 / 胃癌 / 分子標的癌治療 / 標的遺伝子 / 腹膜転移 / スキルス胃癌 / 分子標的治療 / 癌転移 / MDS / 慢性骨髄性白血病 / 急性骨髄性白血病 / 骨髄異形成症候群 / BMI-1 / AML1 Less

白血病、脳腫瘍、肉腫、芽腫に幅広く使える大量生産型CAR-NK細胞療法の開発
- Principal Investigator
  
  今井千速
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  University of Toyama
多発性骨髄腫微小環境の多形核細胞系MDSCを標的とした完全ヒト型他家CAR-T細胞の開発Principal Investigator
- Principal Investigator
  
  三原圭一朗
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Fujita Health University
Development of bispecific CAR-T cells that can be functionally enhanced by COVID-19 vaccine
- Principal Investigator
  
  美山貴彦
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Fujita Health University
骨軟部腫瘍における間葉系幹細胞マーカーMeflinの機能解析と治療法の開発研究
- Principal Investigator
  
  高橋雅英
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Fujita Health University
Development of back bone vectors for chimeric antigen receptors against key molecules, CD47 and CD24, activating macrophages
- Principal Investigator
  
  伊庭善孝
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Fujita Health University
多発性骨髄腫のマクロファージ活性化と協調効果を示すiPSキラーCAR-Tの開発Principal Investigator
- Principal Investigator
  
  三原圭一朗
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Fujita Health University
メモリー様分化誘導を基盤とした多種類のがんに有効なCAR-NK細胞製剤の新規開発
- Principal Investigator
  
  今井千速
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  University of Toyama
  Niigata University
New therapy method to inhibit cancer metastasis-initiating cell targeting ZIP10
- Principal Investigator
  
  TAKEI YOSHIFUMI
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Aichi Gakuin University
Molecular mechanism of enhanced BMI-1 expression in myelodysplastic syndrome with AML1 point mutation.
- Principal Investigator
  
  KIMURA Akiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University
Drug-resistant genes downstream of Polycomb group genes in leukemia stem cellsPrincipal Investigator
- Principal Investigator
  
  MIHARA Keichiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University

All 2023 2022 2021 2020 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] 高リスクくすぶり型骨髄腫の免疫療法へのバイオマーカー2023
- Author(s)
  美山貴彦、三原圭一朗
- Journal Title
  
  血液内科
  
  Volume: 87（2） Pages: 227-232
- Data Source
  KAKENHI-PROJECT-23K24297
[Journal Article] NKp44-based chimeric antigen receptor effectively redirects primary T cells against synovial sarcoma2023
- Author(s)
  Yudai Murayama, Yasushi Kasahara, Nobuhiro Kubo, Chansu Shin, Masaru Imamura, Naoki Oike, Takashi Ariizumi, Akihiko Saitoh, Minori Baba, Tomohiro Miyazaki, Yuko Suzuki, Yiwei Ling, Shujiro Okuda, Keichiro Mihara, Akira Ogose, Hiroyuki Kawashima, Chihaya Imai
- Journal Title
  
  Transl Oncol
  
  Volume: ahead Pages: 1-1
- DOI
  10.1016/j.tranon.2022.101521
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K17850, KAKENHI-PROJECT-23K24297
[Journal Article] Utility of cerebrospinal fluid liquid biopsy in distinguishing <scp>CNS</scp> lymphoma from cerebrospinal infectious/demyelinating diseases2023
- Author(s)
  Iriyama Chisako、Murate Kenichiro、Iba Sachiko、Okamoto Akinao、Goto Naoe、Yamamoto Hideyuki、Kato Toshiharu、Mihara Keichiro、Miyama Takahiko、Hattori Keiko、Kajiya Ryoko、Okamoto Masataka、Mizutani Yasuaki、Yamada Seiji、Tsukamoto Tetsuya、Hirose Yuichi、Mutoh Tatsuro、Watanabe Hirohisa、Tomita Akihiro
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 16 Pages: 16972-16984
- DOI
  10.1002/cam4.6329
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08381, KAKENHI-PROJECT-21K07446, KAKENHI-PROJECT-21K08407, KAKENHI-PROJECT-23K24297
[Journal Article] 未治療移植非適応骨髄腫に対するdaratumumab 併用レジメンと微小残存病変2022
- Author(s)
  美山貴彦、三原圭一朗
- Journal Title
  
  血液内科
  
  Volume: 84(6) Pages: 1-8
- Data Source
  KAKENHI-PROJECT-23K24297
[Journal Article] Acute fulminant intravascular hemolysis induced by Clostridium perfringens in a symptomatic multiple myeloma patient under immuno-chemotherapy2022
- Author(s)
  Yamamoto Hideyuki、Mizutani Yuki、Iriyama Chisako、Goto Naoe、Okamoto Akinao、Kato Toshiharu、Shintani Chiyo、Yamamoto Naoki、Miyama Takahiko、Mihara Keichiro、Okamoto Masataka、Tomita Akihiro
- Journal Title
  
  Annals of Hematology
  
  Volume: 101 Issue: 12 Pages: 2813-2815
- DOI
  10.1007/s00277-022-05010-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08381, KAKENHI-PROJECT-21K08407, KAKENHI-PROJECT-23K24297
[Journal Article] Elevated METTL9 is associated with peritoneal dissemination in human scirrhous gastric cancers2022
- Author(s)
  ToshifumiHara, Yuuki Tominaga, Koji Ueda, Keichiro Mihara, KazuyoshiYanagihara, Yoshifumi Takei
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 30 Pages: 101255-101255
- DOI
  10.1016/j.bbrep.2022.101255
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07698, KAKENHI-PROJECT-22K07159, KAKENHI-PROJECT-23K24297
[Journal Article] 骨髄腫に対する治療薬・治療法の特徴　モノクローナル抗体．2022
- Author(s)
  美山貴彦、三原圭一朗
- Journal Title
  
  内科
  
  Volume: 130(4) Pages: 749-754
- Data Source
  KAKENHI-PROJECT-23K24297
[Journal Article] CD19-positive lymphocyte count is critical for acquisition of anti-SARS-CoV-2 IgG after vaccination in B-cell lymphoma2022
- Author(s)
  Okamoto Akinao、Fujigaki Hidetsugu、Iriyama Chisako、Goto Naoe、Yamamoto Hideyuki、Mihara Keichiro、Inaguma Yoko、Miura Yasuo、Furukawa Katsuya、Yamamoto Yukiya、Akatsuka Yoshiki、Kasahara Senji、Miyao Kotaro、Kajiya Ryoko、Okamoto Masataka、Saito Kuniaki、Tomita Akihiro
- Journal Title
  
  Blood Advances
  
  Volume: 6 Issue: 11 Pages: 3230-3233
- DOI
  10.1182/bloodadvances.2021006302
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08381, KAKENHI-PROJECT-21K08407, KAKENHI-PROJECT-22K11891, KAKENHI-PROJECT-23K24297
[Journal Article] Elevated Expression of CELSR1 is Associated with Peritoneal Metastasis in Human Scirrhous Gastric Cancers2021
- Author(s)
  Toshifumi Hara, Yuri Nomura, Masaaki Hattori, Keichiro Mihara, Kazuyoshi Yanagihara, Yoshifumi Takei
- Journal Title
  
  BPB Reports
  
  Volume: 4 Issue: 4 Pages: 103-111
- DOI
  10.1248/bpbreports.4.4_103
- NAID
  130008074323
- ISSN
  2434-432X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07698, KAKENHI-PROJECT-19H03149
[Journal Article] Long Noncoding RNA HOTAIR Promotes Epithelial-Mesenchymal Transition and Is a Suitable Target to Inhibit Peritoneal Dissemination in Human Scirrhous Gastric Cancers2020
- Author(s)
  Takei Yoshifumi、Hara Toshifumi、Suzuki Akiko、Mihara Keichiro、Yanagihara Kazuyoshi
- Journal Title
  
  Pathobiology
  
  Volume: 87 Issue: 5 Pages: 277-290
- DOI
  10.1159/000508350
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07698, KAKENHI-PROJECT-19H03149
[Journal Article] Rare primary extramedullary hematopoiesis of the thyroid without intranodular vascularity and mutations in the JAK2, MPL, and calreticulin genes2020
- Author(s)
  Matsumura N, Sasaki N, Cho Y, Daimaru Y, Nojima T, Mizuno N, Takei Y, Mihara K.
- Journal Title
  
  Annals of Hematology
  
  Volume: 99 Issue: 9 Pages: 2211-2213
- DOI
  10.1007/s00277-020-04086-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03149
[Journal Article] The metastasis-associated microRNA miR-516a-3p is a novel therapeutic target for inhibiting peritoneal dissemination of human scirrhous gastric cancer.2011
- Author(s)
  Takei Y, Takigahira M, Mihara K, Tarumi Y, Yanagihara K.
- Journal Title
  
  Cancer Res. 71(4)
  
  Pages: 1442-1453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591128
[Journal Article] Expression of CD38 with intracellular enzymatic activity : a possible explanation for the insulin release induced by intracellular cADPR.2011
- Author(s)
  Ohta Y, Kitanaka A, Mihara K, Imataki O, Ohnishi H, Tanaka T, Taminato T, Kubota Y.
- Journal Title
  
  Mol Cell Biochem. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591128
[Journal Article] Expansion of CD8+/perforin+ effector memory T cells in the bone marrow of patients with thymoma-associated pure red cell aplasia.2010
- Author(s)
  Nitta H, Mihara K, Sakai A, Kimura A.
- Journal Title
  
  Br J Haematol. 150(6)
  
  Pages: 712-715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591128
[Journal Article] Synergistic and persistent effect of T-cell immunotherapy with anti-CD19 or anti-CD38 chimeric receptor in conjunction with rituximab on B-cell non-Hodgkin lymphoma.2010
- Author(s)
  Mihara K, Yanagihara K, Takigahira M, Kitanaka A, Imai C, Bhattacharyya J, Kubo T, Takei Y, Yasunaga S, Takihara Y, Kimura A.
- Journal Title
  
  Br J Haematol. 151(1)
  
  Pages: 37-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591128
[Journal Article] Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte.2010
- Author(s)
  Susaki K, Kitanaka A, Dobashi H, Kubota Y, Kittaka K, Kameda T, Yamaoka G, Mano H, Mihara K, Ishida T.
- Journal Title
  
  Immunol Lett. 4;127(2)
  
  Pages: 135-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591128
[Journal Article] Synergistic and persistent effect of T-cell immunotherapy with anti-CD19 or anti-CD38 chimeric receptor on B-cell lymphoma in conjunction with rituximab2010
- Author(s)
  Mihara K, e al
- Journal Title
  
  Br J Haematol.
  
  Volume: 151 Pages: 37-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591128
[Journal Article] An orthotopic implantation mouse model of human malignant pleural mesothelioma for in vivo photon counting analysis and evaluation of the effect of S-1 therapy.2010
- Author(s)
  Yanagihara K, Tsumuraya M, Takigahira M, Mihara K, Kubo T, Ohuchi K, Seyama T.
- Journal Title
  
  Int J Cancer. 126(12)
  
  Pages: 2835-2846
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591128
[Journal Article] Expansion of CD^<8+>/perforin^+ effector memory T cells in the bone marrow of patients with thymoma-associated pure red cell aplasia.2010
- Author(s)
  Nitta, H., Mihara, K., Sakai, A., Kimura A.
- Journal Title
  
  British Journal of Haematology 150(6)
  
  Pages: 712-715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591127
[Journal Article] Activated T-cell-mediated immunotherapy with a chimeric receptor against CD38 in B-cell non-Hodgkin lymphoma.2009
- Author(s)
  Mihara K, et al
- Journal Title
  
  J Immunother. 32
  
  Pages: 737-743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591127
[Journal Article] BMI-1 expression is enhanced through transcriptional and posttranscriptional regulation during the progression of chronic myeloid leukemia.2009
- Author(s)
  Bhattacharyya, J., Mihara, K., Yasunaga, S., Tanaka, H., Hoshi, M., Takihara, Y., Kimura A
- Journal Title
  
  Annals of Hematology 88(4)
  
  Pages: 333-340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591127
[Journal Article] Activated T-cell-mediated immunotherapy with a chimeric receptor against CD38 in B-cell non-Hodgkin lymphoma.2009
- Author(s)
  Mihara K, Yanagihara K, Takigahira M, Imai C, Kitanaka A, Takihara Y, Kimura A.
- Journal Title
  
  J Immunother. 32(7)
  
  Pages: 737-743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591128
[Journal Article] Activated T-cell-mediated immunotherapy with a chimeric receptor against CD38 in B-cell non-Hodgkin lymphoma.2009
- Author(s)
  Mihara K, Yanagihara K, Takigahira M, Imai C, Kitanaka A, Takihara Y, Kimura A
- Journal Title
  
  Journal of Immunotherapy 32(7)
  
  Pages: 737-743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591127
[Journal Article] BMI-1 expression is enhanced through transcriptional and posttranscriptional regulation during the progression of chronic myeloid leukemia.2009
- Author(s)
  Bhattacharyya J, Mihara K, Yasunaga S, Tanaka H, Hoshi M, Takihara Y, Kimura A.
- Journal Title
  
  Ann Hematol. 88(4)
  
  Pages: 333-340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591128
[Journal Article] Antitumor effect of SN-38-releasing polymeric micelles, NK012, on spontaneous peritoneal metastases from orthotopic gastric cancer in mice compared with irinotecan.2008
- Author(s)
  Nakajima TE, Yanagihara K, Takigahira M, Yasunaga M, Kato K, Hamaguchi T, Yamada Y, Shimada Y, Mihara K, Ochiya T, Matsumura Y.
- Journal Title
  
  Cancer Res. 15;68(22)
  
  Pages: 9318-9322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591128
[Presentation] Anti-CD38-CAR IPS-Derived Cytotoxic T Lymphocytes Efficiently Eliminate Myeloma Cells Treated with Daratumumab and Isatuximab in Vitro and In Vivo.2023
- Author(s)
  Hattori Y, Kubo T, Nagano S, Miyama T, Taniguchi Y, Iba Y, Ohshima N, Kanehara R, Kawase T, Takahashi M, Kawamoto H, Mihara K.
- Organizer
  65th ASH Annual Meeting and Exposition
- Data Source
  KAKENHI-PROJECT-23K24297
[Presentation] 低ガンマグロブリン血症患者における重度感染症への免疫グロブリン補充療法の効果.2023
- Author(s)
  Mihara K, Kawase T, Miyama T, Iwasaki K, Shoji A, Matsumaru M.
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24297
[Presentation] マクロファージ活性化のkey分子CD47およびCD24に対するCARバックボーンベクターの開発2023
- Author(s)
  伊庭善孝、三原圭一朗、高橋雅英
- Organizer
  第55回藤田医科大学医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K06728
[Presentation] The impact of immunoglobulin replacement therapy on severe infection in hypogammaglobulinemia.2023
- Author(s)
  Mihara K, Kawase T, Miyama T, Iwasaki K, Shoji A, Matsumaru M.
- Organizer
  EHA2023 Hybrid Congress
- Data Source
  KAKENHI-PROJECT-23K24297
[Presentation] 転移性腫瘍に対するオレイン酸-siRNAコンジュゲートの抗腫瘍効果2023
- Author(s)
  久保貴紀、西村良夫、湛増里奈、栁原五吉、三原圭一朗、瀬山敏雄
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-23K24297
[Presentation] 膵臓がん肝転移マウスモデルに対するLipid-siRNAの抗腫瘍効果2022
- Author(s)
  久保貴紀、湛増里奈、西村良夫、三原圭一朗、柳原五吉、瀬山敏雄
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PROJECT-23K24297
[Presentation] 免疫チェックポイント阻害剤としての脂肪酸結合型siRNA2022
- Author(s)
  久保貴紀，西村良夫、栁原五吉、三原圭一郎、瀬山敏雄
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-23K24297
[Presentation] BMI-1 is correlated with drug resistance in B-cell lymphomas through enhanced expression of survivin.2010
- Author(s)
  Bhattacharyya, J., Mihara, K., Ohtsubo, M., Yasunaga, S., Takihara, Y., Kimura A., Hoshi, M.
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20591127
[Presentation] B-Cell Lymphoma Cells Overexpressing BMI-1 Are Correlated with Drug Resistance through Enhanced Expression of Survivin and Are Effectively Eliminated by T Cells with Anti-CD38 Chimeric Receptor.2010
- Author(s)
  Bhattacharyya, J., Mihara, K., Ohtsubo, M., Yasunaga, S., Takihara, Y., Hoshi, M., Kimura A.
- Organizer
  52nd Annual Meeting of the American Society of Hematology
- Place of Presentation
  Orlando, Florida, USA
- Year and Date
  2010-12-05
- Data Source
  KAKENHI-PROJECT-20591127
[Presentation] B-cell lymphoma cells overexpressing BMI-1 are correlated with drug resistance through enhanced expression of survivin and are effectively eliminated by T cells with anti-CD38 chimeric receptor.2010
- Author(s)
  ジョイータ・バタチャリーヤ, 三原圭一朗, 大坪素秋, 安永晋一郎, 瀧原義宏, 星正治, 木村昭郎
- Organizer
  52nd ASH Annual Meeting
- Place of Presentation
  Orlando, USA
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-20591128
[Presentation] B細胞性リンパ腫におけるBMI-1の高発現はSurvivinの発現を促進し、抗癌剤耐性に関与する2010
- Author(s)
  ジョイータ・バタチャリーヤ, 三原圭一朗, 大坪素秋, 安永晋一郎, 星正治, 瀧原義宏, 木村昭郎
- Organizer
  第71回日本血液学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-20591128
[Presentation] Overexpression of bmi-1 is correlated with drug resistance in b-cell lymphomas through enhanced expression of survivin.2010
- Author(s)
  ジョイータ・バタチャリーヤ, 三原圭一朗, 大坪素秋, 安永晋一郎, 瀧原義宏, 星正治, 木村昭郎
- Organizer
  ISEH2010
- Place of Presentation
  Melbourne Australia
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-20591128
[Presentation] Expansion of CD8^+/perforin^+ effector memory T cells in the bone marrow with thymoma-associated PRCA.2010
- Author(s)
  Nitta, H., Mihara, K., Sakai, A., Kimura A.
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20591127
[Presentation] Synergistic effect of T-cell immunotherapy with anti-CD19 or anti-CD38 chimeric receptor on B-cell lymphoma in conjunction with rituximab2008
- Author(s)
  Mihara K
- Organizer
  International Conference on Malignant Lymphoma
- Place of Presentation
  Lugano, Switzerland
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-20591128
[Presentation] Synergistic and persistent effect of T-cell immunotherapy with anti-CD19 or anti-CD38 chimeric receptor on B-cell lymphoma in conjunction with rituximab2008
- Author(s)
  Mihara K
- Organizer
  American Society of Hematology, Annual Meeting
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2008-12-07
- Data Source
  KAKENHI-PROJECT-20591128

1. 久保貴紀 (90435751)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. 伊庭善孝 (90298547)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 今井千速 (90419284)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 今村勝 (80464006)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KIMURA Akiro (70127645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. TAKIHARA Yoshihiro (60226967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. TAKEI YOSHIFUMI (70362233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 河本宏 (00343228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 高橋雅英 (40183446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 大島信子 (60387694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 服部裕次 (90973488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 美山貴彦 (00770330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 冨田章裕 (80378215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 加藤省一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 岡本晃直

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
16. 原敏文

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 凌一葦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mihara Keichiro 三原 圭一朗

MIHARA Keichiro 三原 圭一朗

Research Projects

Research Products

Co-Researchers

白血病、脳腫瘍、肉腫、芽腫に幅広く使える大量生産型CAR-NK細胞療法の開発

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多発性骨髄腫微小環境の多形核細胞系MDSCを標的とした完全ヒト型他家CAR-T細胞の開発Principal Investigator

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Development of bispecific CAR-T cells that can be functionally enhanced by COVID-19 vaccine

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骨軟部腫瘍における間葉系幹細胞マーカーMeflinの機能解析と治療法の開発研究

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Development of back bone vectors for chimeric antigen receptors against key molecules, CD47 and CD24, activating macrophages

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多発性骨髄腫のマクロファージ活性化と協調効果を示すiPSキラーCAR-Tの開発Principal Investigator

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メモリー様分化誘導を基盤とした多種類のがんに有効なCAR-NK細胞製剤の新規開発

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New therapy method to inhibit cancer metastasis-initiating cell targeting ZIP10

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Molecular mechanism of enhanced BMI-1 expression in myelodysplastic syndrome with AML1 point mutation.

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Drug-resistant genes downstream of Polycomb group genes in leukemia stem cellsPrincipal Investigator

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[Journal Article] 高リスクくすぶり型骨髄腫の免疫療法へのバイオマーカー2023

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[Journal Article] NKp44-based chimeric antigen receptor effectively redirects primary T cells against synovial sarcoma2023

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[Journal Article] Utility of cerebrospinal fluid liquid biopsy in distinguishing <scp>CNS</scp> lymphoma from cerebrospinal infectious/demyelinating diseases2023

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[Journal Article] 未治療移植非適応骨髄腫に対するdaratumumab 併用レジメンと微小残存病変2022

Mihara Keichiro 三原圭一朗

MIHARA Keichiro 三原圭一朗

[Journal Article] 骨髄腫に対する治療薬・治療法の特徴　モノクローナル抗体．2022