Higuchi Mariko 樋口真理子

… Alternative Names

HIGUCHI Mariko 樋口真理子

Less

Researcher Number	90370460
Affiliation (Current)	2025: 国立研究開発法人日本原子力研究開発機構, 原子力基礎工学研究部門, 任期付研究員
Affiliation (based on the past Project Information) *help	2014: 独立行政法人日本原子力研究開発機構, 原子力科学研究部門原子力基礎工学研究センター, 任期付研究員 2013: 独立行政法人日本原子力研究開発機構, 原子力科学研究部門量子ビーム応用研究センター, 任期付研究員 2013: 独立行政法人日本原子力研究開発機構, 原子力科学研究部門原子力基礎工学研究センター, 任期付研究員 2013: 独立行政法人日本原子力研究開発機構・原子力科学研究部門, 原子力基礎工学研究センター, 任期付研究員 2012: 独立行政法人日本原子力研究開発機構, 原子力基礎工学研究部門, 研究職 … More 2010 – 2012: 独立行政法人日本原子力研究開発機構, 原子力基礎工学研究部門, 任期付研究員 2009: 独立行政法人日本原子力研究開発機構, 原子力基礎工学研究部門, 研究員 2006: JAEA, QuBS, Post Doctoral, 量子ビーム応用研究部門, 博士研究員 2005: 独立行政法人, 日本原子力研究開発機構・量子ビーム応用研究部門・中性子生命科学ユニット, 博士研究員 2004: 特殊法人日本原子力研究所, 中性子利用研究センター, 博士研究員 Less
Review Section/Research Field	Except Principal Investigator Risk sciences of radiation/Chemicals / Biophysics
Keywords	Except Principal Investigator RuvA / MutT / 分子動力学 / 突然変異 / molecular dynamics / molecular evolution / DNA photolyase / database / genome / DNA repair protein … More / アノテーション / 分子進化 / DNAホトリアーゼ / データベース / ゲノム / DNA修復タンパク質 / 生物影響 / テラヘルツ分光 / 分子動力学計算 / DNA分子構造 / FRET / 難修復性 / 蛍光共鳴エネルギー移動 / 分子構造 / 複雑損傷 / 分子動力学法 / 塩基除去修復 / シンクロトロン放射 / クラスターDNA / DNA損傷 / トラック構造 / 電子常磁性共鳴装置 / 塩基損傷 / 不対電子種 / モンテカルロシミュレーション / 塩基除去修復酵素 / APサイト / DNAラジカル / EPR / 軟X線 / DNA修復 / イオンビーム / シンクロトロン放射光 / 放射線 / クラスターDNA損傷 Less

Research on molecular structure and repair of complex DNA damage
- Principal Investigator
  
  SHIKAZONO Naoya
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Japan Atomic Energy Agency
Study of radiation-induced cluster DNA damage- its structure and repair susceptibility
- Principal Investigator
  
  YOKOYA Akinari
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Japan Atomic Energy Agency
Function annotation of DNA repair related proteins using molecular evolution information and computer simulation of protein dynamics
- Principal Investigator
  
  YURA Kei
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Japan Atomic Energy Agency

All 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] A possible overestimation of the effect of acetylation on lysine residues in KQ mutant analysis2012
- Author(s)
  Hirofumi Fujimoto, Mariko Higuchi, Manabu Koike, Hirotaka Ode, Miroslav Pinak, Juraj Kotulic Bunta, Toshiyuki Nemoto, Takashi Sakudoh, Naoko Honda, Hideaki Maekawa, Kimiaki Saito, Kozo Tsuchida
- Journal Title
  
  J. Comput. Chem
  
  Volume: 33 Issue: 3 Pages: 239-246
- DOI
  10.1002/jcc.21956
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21510063, KAKENHI-PROJECT-22310038
[Journal Article] Enhanced resolution of molecular recognition to distinguish structurally similar molecules by different conformational responses of a protein uponligand binding2011
- Author(s)
  Mariko Higuchi
- Journal Title
  
  Journal of Structural Biology
  
  Volume: 173 Pages: 20-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310041
[Journal Article] Enhanced resolution of molecular recognition to distinguish structure similar molecules by different conformational responses of a protein upon ligand binding2011
- Author(s)
  Higuchi M, Fujii J, Yonetani Y, Kitao A, Go N
- Journal Title
  
  Journal of Structural Biology
  
  Volume: 173 Pages: 20-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310038
[Presentation] 修復酵素hOgg1と二つの損傷が近くにあるDNAの結合に関する研究2011
- Author(s)
  樋口真理子、M.Pinak
- Organizer
  第49回日本生物物理学会
- Place of Presentation
  姫路(日本)
- Year and Date
  2011-09-18
- Data Source
  KAKENHI-PROJECT-22310038
[Presentation] Inhibition of binding of Fpg to multiple damaged DNA2011
- Author(s)
  樋口真理子、M.Pinak
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜(日本)
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22310038
[Presentation] Inhibition of binding of Fpg to mviltiple damaged DNA2011
- Author(s)
  Mariko Higuchi
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21310041
[Presentation] 修復酵素hOGG1によるクラスターDNA損傷の修復阻害に関するシミュレーション2011
- Author(s)
  樋口真理子
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21310041
[Presentation] The affinity of dose-two-damages and repair hOGG12011
- Author(s)
  Mariko Higuchi
- Organizer
  第49回日本生物物理学会年会
- Place of Presentation
  姫路
- Data Source
  KAKENHI-PROJECT-21310041
[Presentation] Molecular dynamics simulation of cluster damaged DNA and hOGG12010
- Author(s)
  Higuchi M, Pinak M
- Organizer
  11th International Workshop on Radiation Damage to DNA
- Place of Presentation
  アトランタ(米国)
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-22310038
[Presentation] クラスターDNA損傷が修復酵素hOGG1の結合に関する分子動力学シミュレーション2010
- Author(s)
  樋口真理子, Pinak M.
- Organizer
  第48回日本生物物理学会年会
- Place of Presentation
  仙台(日本)
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-22310038
[Presentation] クラスターDNA損傷が修復酵素hOGG1の基質認識に及ぼす影響2010
- Author(s)
  樋口真理子, Pinak M.
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌(日本)
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-22310038
[Presentation] Ku binds to complex damaged double strand break DNA
- Author(s)
  Higuchi, M.
- Organizer
  第12回日本蛋白質科学会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Data Source
  KAKENHI-PROJECT-22310038

1. YOKOYA Akinari (10354987)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. SHIKAZONO Naoya (10354961)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. FUJII Kentaro (00360404)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. WATANABE Ritsuko (10360439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NOGUCHI Miho (40455283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OKA Toshitaka (70339745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. AKAMATSU Ken (70360401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MURAKAMI Hiroshi (50291092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. URUSHIBARA Ayumi (80391275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YURA Kei (50252226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ISHIDA Hisashi (60360418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山下真一 (20511489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SAKUDOH Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 小池学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 藤本浩文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 土田耕三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higuchi Mariko 樋口 真理子

HIGUCHI Mariko 樋口 真理子

Research Projects

Research Products

Co-Researchers

Research on molecular structure and repair of complex DNA damage

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of radiation-induced cluster DNA damage- its structure and repair susceptibility

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Function annotation of DNA repair related proteins using molecular evolution information and computer simulation of protein dynamics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A possible overestimation of the effect of acetylation on lysine residues in KQ mutant analysis2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced resolution of molecular recognition to distinguish structurally similar molecules by different conformational responses of a protein uponligand binding2011

Author(s)

Journal Title

Data Source

[Journal Article] Enhanced resolution of molecular recognition to distinguish structure similar molecules by different conformational responses of a protein upon ligand binding2011

Author(s)

Journal Title

Data Source

[Presentation] 修復酵素hOgg1と二つの損傷が近くにあるDNAの結合に関する研究2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Inhibition of binding of Fpg to multiple damaged DNA2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Inhibition of binding of Fpg to mviltiple damaged DNA2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 修復酵素hOGG1によるクラスターDNA損傷の修復阻害に関するシミュレーション2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] The affinity of dose-two-damages and repair hOGG12011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Molecular dynamics simulation of cluster damaged DNA and hOGG12010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] クラスターDNA損傷が修復酵素hOGG1の結合に関する分子動力学シミュレーション2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] クラスターDNA損傷が修復酵素hOGG1の基質認識に及ぼす影響2010

Author(s)

Organizer

Place of Presentation

Year and Date

Higuchi Mariko 樋口真理子

HIGUCHI Mariko 樋口真理子