KOURO Taku 紅露拓

… Alternative Names

紅露拓コウロタク

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Researcher Number	90372424
Other IDs
Affiliation (Current)	2025: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所がん免疫療法研究開発学部, チームリーダー 2025: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所, 技師・研究員
Affiliation (based on the past Project Information) *help	2023: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所がん免疫療法研究開発学部, チームリーダー 2019: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所, 技師・研究員 2018: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所, 研究員 2012: 独立行政法人医薬基盤研究所, その他部局等, 研究員 2010 – 2011: 独立行政法人医薬基盤研究所, 創薬基盤研究部, プロジェクトリーダー 2006 – 2008: (独)医薬基盤研究所, 免疫応答制御プロジェクト, プロジェクトリーダー 2004 – 2005: 東京大学, 医科学研究所, 助手
Review Section/Research Field	Principal Investigator Immunology / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Medium-sized Section 50:Oncology and related fields / Immunology
Keywords	Principal Investigator B-1細胞 / 腫瘍浸潤リンパ球 / シングルセル解析 / TCR-T / インフルエンザ / 経鼻ワクチン / 自然抗体 / SCIDマウス / ストロマ細胞 / 腸管免疫 … More / IgA / プロB細胞 / 自然免疫 / 初期分化 / 前駆細胞 / 免疫学 / インターロイキン5 … More Except Principal Investigator Ｂ細胞受容体 / Ｂ細胞 / レパトア / B細胞受容体 / 有害事象 / 抗腫瘍効果 / 免疫チェックポイント阻害剤 / バイオマーカー / 抗原 / B細胞受容体レパトア / B細胞 / 抗PD-1抗体 / APS / Lnk / クラススイッチ組換え / IgA / Bリンパ球 / IL-5 / 造血幹細胞 / 結核菌 / クラススイッチ / B-1細胞 / インターロイキン5 / リンパ球 / クラススイッチ変換 / アダプター分子 / インターロイキン / 自然免疫 / 免疫学 Less

シングルセル解析による新たなTCR-T細胞作製法の検討ー個別化TCR-T細胞療法に向けてPrincipal Investigator
- Principal Investigator
  
  紅露拓
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kanagawa Cancer Center Research Institute
Analysis of B cell repertoires and their antigen specificity in peripheral blood from cancer patients undergoing anti-PD-1 antibody therapy.
- Principal Investigator
  
  Sasada Tetsuro
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Kanagawa Cancer Center Research Institute
鼻粘膜における交叉防御性抗体産生機構の解明Principal Investigator
- Principal Investigator
  
  紅露拓
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  独立行政法人医薬基盤研究所
Investigation of regulatory mechanisms for homeostasis and activation of lymphocyte
- Principal Investigator
  
  TAKATSU Kiyoshi
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
  University of Toyama
B細胞亜集団の起源-B-1細胞の初期発生・分化機構Principal Investigator
- Principal Investigator
  
  紅露拓
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo

All 2023 2019 2018 2012 2011 2010 2009 2007 2006

All Journal Article Presentation Book

[Book] プレシジョン・メディシン　～ビッグデータの構築・分析から臨床応用・課題まで～.　 (第2編第3章第3節) 変異遺伝子を標的とした個別化がん免疫療法の開発.2018
- Author(s)
  紅露拓，笹田哲朗.
- Total Pages
  406
- Publisher
  エヌ・ティー・エス
- ISBN
- Data Source
  KAKENHI-PROJECT-18K19490
[Journal Article] Prospects for a personalized peptide vaccine against lung cancer.2019
- Author(s)
  Nakahara Y, Kouro T, Igarashi Y, Kawahara M, Sasada T.
- Journal Title
  
  Expert Rev Vaccines.
  
  Volume: 18 Issue: 7 Pages: 703-709
- DOI
  10.1080/14760584.2019.1635461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04278, KAKENHI-PROJECT-18K19490, KAKENHI-PROJECT-16H06277
[Journal Article] Identification of Novel HLA Class II-Restricted Neoantigens Derived from Driver Mutations2019
- Author(s)
  Iiizumi Susumu、Ohtake Junya、Murakami Naoko、Kouro Taku、Kawahara Mamoru、Isoda Fumiko、Hamana Hiroshi、Kishi Hiroyuki、Nakamura Norihiro、Sasada Tetsuro
- Journal Title
  
  Cancers
  
  Volume: 11 Issue: 2 Pages: 266-266
- DOI
  10.3390/cancers11020266
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19441, KAKENHI-PROJECT-18K19490, KAKENHI-PLANNED-16H06499, KAKENHI-PROJECT-17H04278, KAKENHI-PROJECT-18K07260, KAKENHI-PROJECT-16H06277
[Journal Article] 遺伝子変異由来ネオアンチゲンを標的とした特異的免疫療法.2019
- Author(s)
  紅露拓，笹田哲朗
- Journal Title
  
  医学のあゆみ
  
  Volume: 271 Pages: 163-168
- Data Source
  KAKENHI-PROJECT-18K19490
[Journal Article] Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity2012
- Author(s)
  Ikutani M.
- Journal Title
  
  J Immunol
  
  Volume: 188(2) Issue: 2 Pages: 703-713
- DOI
  10.4049/jimmunol.1101270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590433, KAKENHI-PUBLICLY-22117509, KAKENHI-PROJECT-22590446, KAKENHI-PROJECT-22590447, KAKENHI-PROJECT-23659247, KAKENHI-PUBLICLY-23122506
[Journal Article] IL-5による自然免疫制御-B-1細胞と好酸球2010
- Author(s)
  紅露拓
- Journal Title
  
  医学のあゆみ
  
  Volume: 234 Pages: 458-463
- Data Source
  KAKENHI-PROJECT-22590447
[Journal Article] Role of IL-5 in the Immune response to inflammation2009
- Author(s)
  Takatsu K, Kouro T, Nagai Y
- Journal Title
  
  Adv. Immunol 101
  
  Pages: 191-236
- Data Source
  KAKENHI-PROJECT-16109004
[Journal Article] IL-5-induced eosinophils can suppress the antigen-induced immune response via a TGF-β-dependent mechanism2007
- Author(s)
  Nakagome K, Dohi M, Okunishi K, Taanaka R, T. Kouro T, Kano MR, Miyazono K, Miyazaki J, Takatsu K, Yamamoto K
- Journal Title
  
  J. Immunol 179
  
  Pages: 284-294
- Data Source
  KAKENHI-PROJECT-16109004
[Presentation] 腎がん浸潤T細胞のシングルセル解析による特異的TCR同定と腎がんオルガノイドを用いた抗腫瘍反応の検証2023
- Author(s)
  洞口俊、紅露拓、氷室秀知、魏菲菲、眞野恭伸、辻嘉代子、神谷郁也、上原秀一郎、星野大輔、笹田哲朗
- Organizer
  第８２回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K06782
[Presentation] 腎がん患者由来オルガノイドの樹立と免疫学的解析の試み2023
- Author(s)
  辻嘉代子、中村有子、紅露拓、魏菲菲、眞野恭伸、洞口俊、氷室秀知、星野大輔、川村猛、笹田哲朗
- Organizer
  第２７回日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-23K06782
[Presentation] Optimization of CAR T cells recognizing malignant mesothelioma specific antigen.2019
- Author(s)
  Taku Kouro, Kohzoh Imai, Tetsuro Sasada.
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K19490
[Presentation] Changes of BCR repertoire are predictive biomarker for the efficacy of immune checkpoint inhibitor in NSCLC.2019
- Author(s)
  Yoshiro Nakahara, Norikazu Matsuo, Koichi Azuma, Yoshiko Naito, Hidenobu Ishii, Takaaki Tokito, Yuka Igarashi, Taku Kouro, Ryo Usui, Tadasuke Shimokawaji, Tetsuro Kondo, Terufumi Kato, Haruhiro Saito, Kouzo Yamada, Tomoaki Hoshino, Tetsuro Sasada.
- Organizer
  第17回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-18K19490
[Presentation] Immunogenicity of frequent driver mutations; identification of novel HLA class II-restricted neoantigens.2019
- Author(s)
  Susumu Iiizumi, Junya Ohtake, Taku Kouro, Mamoru Kawahara, Yuka Igarashi, Norihiro Nakamura, Tetsuro Sasada.
- Organizer
  第23回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K19490
[Presentation] Optimization of chimeric antigen receptor construct targeting malignant mesothelioma antigen.2019
- Author(s)
  Taku Kouro, Shoutaro Tsuji, Kohzoh Imai, Tetsuro Sasada.
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K19490
[Presentation] Immunogenicity of HLA class II-restricted neoantigens derived from driver mutations.2019
- Author(s)
  Sasada T, Iiizumi S, Kouro T, Kawahara M, Nakamura N.
- Organizer
  Fifth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19490
[Presentation] Generation of CAR T cells recognizing malignant mesothelioma specific antigen2018
- Author(s)
  Taku Kouro, Erica Yada, Mamoru Kawahara, Kozo Imai, Tetsuro Sasada.
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K19490
[Presentation] Immunogenicity and specificity of neoantigens derived from tumor-specific mutations in gastric cancer.2018
- Author(s)
  Sasada T, Ohtake J, Iizumi S, Kouro T, Igarashi Y, Kawahara M, Yada E.
- Organizer
  The 33rd Annual Meeting of the Society for Immunotherapy of Cancer (SITC 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19490
[Presentation] Identification of therapeutic-specific mutations induced by gemcitabine and nab-Paclitaxel in pancreatic cancer.2018
- Author(s)
  Erica Yada, Taku Kouro,Tetsuro Sasada, Satoshi Wada.
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K19490
[Presentation] B-1 cell supports antigen specific IgA production induced by the intranasal influenza vaccine2011
- Author(s)
  篠田香織、飯田隆治、服部祐紀、紅露拓
- Organizer
  日本免疫学会第40回学術集会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22590447
[Presentation] インフルエンザワクチン経鼻投与時の免疫応答機構の解析-ブルトン型チロシンキナーゼの関与2010
- Author(s)
  紅露拓
- Organizer
  日本ワクチン学会
- Place of Presentation
  東京
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-22590447
[Presentation] Parcipitation of Bruton's tyrosine kinase in immune response to nasal influenza vaccination.2010
- Author(s)
  Kouro, T.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-22590447
[Presentation] Genes involved in Btk-dependent pro-B to pre-B transition, Keystone Symposia2007
- Author(s)
  Ikutani M, Kouro T, Takaki S, Takatsu K
- Organizer
  Banff
- Place of Presentation
  Canada
- Data Source
  KAKENHI-PROJECT-16109004
[Presentation] Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment2006
- Author(s)
  Nagai Y, Garrett KP, Ohta S, Bahrun U, Kouro T, Akira S, Takatsu K, Kincade PW
- Organizer
  第36回日本免疫学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-16109004
[Presentation] Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment2006
- Author(s)
  Nagai Y, Garrett KP, Ohta S, Bahrun U, Kouro T, Akira S, Takastu K, Kincade PW
- Organizer
  A Joint Meeting of the Society of Leukocyte Biology and the International Endotoxin and Innate Immunity Society
- Place of Presentation
  San Antonio, TX
- Data Source
  KAKENHI-PROJECT-16109004
[Presentation] Expression of IL-5 receptor a chain on B-1 cell progression2006
- Author(s)
  Kouro T, Ikutani M, Takatsu K
- Organizer
  第36回日本免疫学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-16109004

1. TAKATSU Kiyoshi (10107055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. TAKAKI Satoshi (10242116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. NAGAI Yoshinori (30431761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. TAMURA Toshiki (40291306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Sasada Tetsuro (70293967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
6. 刈米アイ (50114450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 辻嘉代子 (60584232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 岸裕幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOURO Taku 紅露 拓

紅露 拓 コウロ タク

Research Projects

Research Products

Co-Researchers

シングルセル解析による新たなTCR-T細胞作製法の検討ー個別化TCR-T細胞療法に向けてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of B cell repertoires and their antigen specificity in peripheral blood from cancer patients undergoing anti-PD-1 antibody therapy.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

鼻粘膜における交叉防御性抗体産生機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of regulatory mechanisms for homeostasis and activation of lymphocyte

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

B細胞亜集団の起源-B-1細胞の初期発生・分化機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] プレシジョン・メディシン ～ビッグデータの構築・分析から臨床応用・課題まで～. (第2編 第3章 第3節) 変異遺伝子を標的とした個別化がん免疫療法の開発.2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Prospects for a personalized peptide vaccine against lung cancer.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Novel HLA Class II-Restricted Neoantigens Derived from Driver Mutations2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 遺伝子変異由来ネオアンチゲンを標的とした特異的免疫療法.2019

Author(s)

Journal Title

Data Source

[Journal Article] Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-5による自然免疫制御-B-1細胞と好酸球2010

Author(s)

Journal Title

Data Source

[Journal Article] Role of IL-5 in the Immune response to inflammation2009

Author(s)

Journal Title

Data Source

[Journal Article] IL-5-induced eosinophils can suppress the antigen-induced immune response via a TGF-β-dependent mechanism2007

Author(s)

Journal Title

Data Source

[Presentation] 腎がん浸潤T細胞のシングルセル解析による特異的TCR同定と腎がんオルガノイドを用いた抗腫瘍反応の検証2023

Author(s)

Organizer

Data Source

[Presentation] 腎がん患者由来オルガノイドの樹立と免疫学的解析の試み2023

Author(s)

Organizer

Data Source

KOURO Taku 紅露拓

紅露拓コウロタク

[Book] プレシジョン・メディシン　～ビッグデータの構築・分析から臨床応用・課題まで～.　 (第2編第3章第3節) 変異遺伝子を標的とした個別化がん免疫療法の開発.2018