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SAKAKI Hirotaka  榊 宏剛

ORCIDConnect your ORCID iD *help
Researcher Number 90374850
Other IDs
Affiliation (based on the past Project Information) *help 2016: 弘前大学, 医学研究科, 客員研究員
2010 – 2015: 弘前大学, 医学部附属病院, 講師
2010: 弘前大学, 医学部・附属病院, 講師
2007 – 2009: Hirosaki University, 医学部附属病院, 助教
2008: Hirosaki University, 医学部・附属病院, 助教
2005 – 2006: Hirosaki University, University Hospital, Assistant, 医学部附属病院, 助手
2004: 弘前大学, 医学部附属病院, 医員
Review Section/Research Field
Principal Investigator
Surgical dentistry
Except Principal Investigator
Surgical dentistry
Keywords
Principal Investigator
RIG-I / 細胞周期 / 癌 / 口腔癌細胞 / 歯学 / 遺伝子 / 口腔 / 自然免疫 / 口腔癌 / poly-IC … More / 感染防御機構 / 口腔粘膜 / poly IC / LPS … More
Except Principal Investigator
細胞・組織 / 再生医学 / メカニカルストレス / OPG / シグナル伝達 / COX-2 / Regulation of expression / Signal transduction / Stress / tissue / Cell / Tissue engineering / 発現制御 / ストレス / fibroblasts / osteoblasts / vibratory stimulation / mechanical stress / BMP-4 / Cbfa-1 / NO / 炎症性サイトカイン / 顎骨 / 再生医療 / 線維芽細胞 / 振動刺激 / 骨芽細胞 / 骨増生法 / 臨床 / 移植・再生医療 / 歯学 / 骨リモデリング / BMP signaling / Wnt signaling / BMP pathway / Wnt pathway / 骨代謝 / メカノセンサー / 骨膜 / シグナル伝達経路 / 組織・細胞 / RANKL / MAPK活性化 / 細胞継代・細胞老化 / ヒト骨芽細胞 / MAPK / 細胞老化 / 周期的伸展刺激 / 遺伝子解析 / COX-2インヒビター / 転移抑制 / MMP / 口腔癌 Less
  • Research Projects

    (10 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (11 People)
  •  Study on target of cancer immunoediting in oral cancerPrincipal Investigator

    • Principal Investigator
      Sakaki Hirotaka
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hirosaki University
  •  Development of the new bone regeneration method by transplanting jawbone periosteum sheets as a mechanosensor.

    • Principal Investigator
      KIMURA Hiroto
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hirosaki University
  •  Development for the cancer therapy to regulate cell cycle and stimulating immune system by novel gene networksPrincipal Investigator

    • Principal Investigator
      SAKAKI Hirotaka
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hirosaki University
  •  Development for the cancer therapy to regulate cell cycle by novel gene RIG-IPrincipal Investigator

    • Principal Investigator
      SAKAKI Hirotaka
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hirosaki University
  •  Analyses of mechanical stress-induced bone formation and metabolism on aging osteoblasts and osteo-like cells

    • Principal Investigator
      KUSUMI Akinori
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hirosaki University
  •  The development for newly treatment of oral cancer by transfection of RIG-I, novel differentiation induction genePrincipal Investigator

    • Principal Investigator
      SAKAKI Hirotaka
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hirosaki University
  •  口腔癌の転移抑制を目指したMMPインヒビター療法開発のための基礎的研究

    • Principal Investigator
      KIMURA Hiroto
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Hirosaki University
  •  口腔粘膜における感染防御機構の解明ならびに遺伝子治療の基礎的研究Principal Investigator

    • Principal Investigator
      榊 宏剛
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hirosaki University
  •  Analyses of bone formation and reconstruction with human osteoblasts and mouse osteoblastic cells with the application of mechanical stress.

    • Principal Investigator
      KUSUMI Akinori
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hirosaki University
  •  Basic and clinical study aimed for the regenerative medicine of jaw bone by vibratory stimulation system

    • Principal Investigator
      KIMURA Hiroto
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hirosaki University

All 2016 2015 2014 2012 2011 2010 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

  • [Book] Nakane A et al eds. Emerging Theories of Host Defense2007

    • Author(s)
      Kusumi A, Sakaki H, Kusumi T, Nakagawa H, Kubota K, Oda M, Satoh H, Kimura H.
    • Total Pages
      301
    • Publisher
      The influence of serial passage on cyclic tensile strain-induced osteoprotegerin synthesis from normal human osteoblasts in vitro. Hirosaki University Press. Hirosaki University Press
    • Data Source
      KAKENHI-PROJECT-19592280
  • [Journal Article] Can Superselective Intra-Arterial Chemoradiotherapy Replace Surgery Followed by Radiation for Advanced Cancer of the Tongue and Floor of the Mouth?2016

    • Author(s)
      Kobayashi W, Kukobota K, Ito R, Sakaki H, Nakagawa H, Teh BG.
    • Journal Title

      J Oral Maxillofac Surg

      Volume: 74 Issue: 6 Pages: 1248-54

    • DOI

      10.1016/j.joms.2016.01.007

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462992
  • [Journal Article] Identification of a point mutation in the SH3BP2 gene in cherubism2015

    • Author(s)
      Sakaki H, Matsumiya T, Furudate F, Kobayashi W, Kon T, Itoh R, Kimura H
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 27 Issue: 6 Pages: 880-3

    • DOI

      10.1016/j.ajoms.2015.03.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460567, KAKENHI-PROJECT-26462992
  • [Journal Article] Sjogren's syndrome with marked swelling of major salivary glands related to localized AL amyloidosis: A case report and literature review2015

    • Author(s)
      Kubota K, Furudate K, Nakagawa K,Sakaki H, Kobayashi W, Kimura H
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 27 Issue: 4 Pages: 518-21

    • DOI

      10.1016/j.ajoms.2014.09.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462992
  • [Journal Article] Professional oral health care reduces oral mucositis pain in patients treated by superselective intra-arterial chemotherapy concurrent with radiotherapy for oral cancer.2015

    • Author(s)
      Kubota K, Kobayashi W, Sakaki H, Nakagawa H, Kon T, Mimura M, Ito R, Furudate K, Kimura H
    • Journal Title

      Support Care Cancer.

      Volume: 23 Issue: 11 Pages: 3323-3329

    • DOI

      10.1007/s00520-015-2774-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462992
  • [Journal Article] Periosteum-derived cells respond to mechanical stretch and activate Wnt andBMP signaling pathways2014

    • Author(s)
      Ito R, Matsumiya T, Kon T, Narita N, Kubota K, Sakaki H, Ozaki T, Imaizumi T, Kobayashi W, Kimura H
    • Journal Title

      Biomed. Res.

      Volume: 35 Issue: 1 Pages: 69-79

    • DOI

      10.2220/biomedres.35.69

    • NAID

      130004903861

    • ISSN
      0388-6107, 1880-313X
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592979
  • [Journal Article] Periosteum-derived cells respond to mechanical stretch and activate Wnt and BMP signaling pathways2014

    • Author(s)
      Ryohei Ito, Tomoh Matsumiya, Takao Kon, Norihiko Narita, Kosei Kubota, Hirotaka Sakaki, Hidemi Yoshida, Tadaatsu Imaizumi, Wataru Kobayashi, Hiroto Kimura
    • Journal Title

      Biomedical Reserch

      Volume: vol.35 Pages: 69-79

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592979
  • [Journal Article] 口腔癌頸部リンパ節転移に対するドセタキセルとネダプラチンによる超選択的動注を用いた化学放射線療法の有効性2012

    • Author(s)
      小林恒、佐藤寿、榊宏剛、中川祥、久保田耕世、成田憲司、今敬生、成田紀彦、鄭明源、木村博人
    • Journal Title

      日本口腔科学会雑誌

      Volume: 61巻1号 Pages: 8-15

    • NAID

      10030795626

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23792309
  • [Journal Article] 機能温存を目指した口腔癌治療進行口腔癌に対する超選択的動注化学放射線治療について2012

    • Author(s)
      小林恒、榊宏剛、掛端伸也、川口英夫、鄭明源、高井良尋、木村博人
    • Journal Title

      頭頸部癌

      Volume: 38巻3号 Pages: 300-303

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23792309
  • [Journal Article] Superselective intra-arterial chemoradiotherapy with docetaxel-nedaplatin for advanced oral cancer2010

    • Author(s)
      Kobayashi W., Teh B.G., Sakaki H., Sato H., Kimura H., Kakehata S., Nagahata M.
    • Journal Title

      Oral Oncol. 20

      Volume: 46(12) Pages: 860-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791964
  • [Journal Article] Superselective intra-arterial chemoradiotherapy with docetaxel-nedaplatin for advanced oral cancer2010

    • Author(s)
      Kobayashi W, Teh BG, Sakaki H, Sato H, Kimura H, Kakehata S, Nagahata M
    • Journal Title

      Oral Oncol

      Volume: 46 Pages: 860-863

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791964
  • [Journal Article] 口腔癌に対するdocetaxelとnedaplatinを用いた超選択的動注化学放射線治療の臨床的検討2010

    • Author(s)
      小林恒, 鄭明源, 榊宏剛, 佐藤寿, 中川祥, 久保田耕世, 木村博人
    • Journal Title

      頭頚部癌

      Volume: 36(3) Pages: 297-302

    • NAID

      10029079590

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791964
  • [Journal Article] A case of pleomorphic adenoma in the palate detected by positron emissiontomography / computed tomography screening for cancer2008

    • Author(s)
      Sakaki H
    • Journal Title

      Asian J Oral Maxillofac Surg 20

      Pages: 97-101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19791479
  • [Journal Article] A case of pleomorphic adenoma in the palate detected by positron emission tomography/computed tomography screening for cancer2008

    • Author(s)
      Sakaki H、 Satoh H、 Kobayashi W、Narita K、Asano T、Kimura H
    • Journal Title

      Asian J Oral Maxillofac Surg 20

      Pages: 97-101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19791479
  • [Journal Article] Decreased expression of claudin-1 is correlated with recurrence status in esophageal squamous cell carcinoma2008

    • Author(s)
      Miyamoto K, Kusumi T, Sato F, Kawasaki H, Shibata S, Ohashi M, Hakamada K, Sasaki M, Kijima H.
    • Journal Title

      Biomed Res 29

      Pages: 71-76

    • NAID

      130004724051

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592280
  • [Journal Article] Establishment of transplantable murine osteosarcoma cell line with endochondral ossification2008

    • Author(s)
      Nishi T, Kusumi T, Tanaka M, Sato F, Sasaki M, Kudo H, Kijima H
    • Journal Title

      Anticancer Res 28

      Pages: 1627-1631

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592280
  • [Journal Article] Decreased expression of claudin-1 correlates with recurrence status in breast cancer2007

    • Author(s)
      Morohashi S, Kusumi T, Sato F, Odagiri H, Chiba H, Yoshihara S, Hakamada K, Sasaki M, Kijima H
    • Journal Title

      Int J Mol Med 20

      Pages: 139-143

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592280
  • [Journal Article] Expression of vascular endothelial growth factor by photodynamic therapy with mono-L-aspartyl chlorin e6(NPe6)in oral squamous cell carcinoma2007

    • Author(s)
      Nakagawa H, Matsumiya T, Sakaki H, Imaizumi T, Kubota K, Kusumi A, Kobayashi W, Kimura H.
    • Journal Title

      Oral Oncol 43

      Pages: 544-550

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592280
  • [Journal Article] Expression of vascular endothelial growth factor by photodynamic therapy with mono-l-aspartyl chlorin e6 (NPe6) in oral squamous cell carcinoma.2007

    • Author(s)
      Nakagawa H, Matsumiya T, Sakaki H, Imaizumi T, Kubota K, Kusumi A, Kobayashi W, Kimura H
    • Journal Title

      Oral Oncology 43(印刷中)

    • Data Source
      KAKENHI-PROJECT-17659626
  • [Journal Article] Retinoic Acid-Inducible Gene-I is induced in gingival fibroblasts by LPS or poly IC : possible roles in Interleukin-1β, -6 and -8 expression2006

    • Author(s)
      Kubota K., Sakaki H., et al.
    • Journal Title

      Oral Microbiol Immunol 21(6)

      Pages: 399-406

    • Data Source
      KAKENHI-PROJECT-17791434
  • [Journal Article] Retinoic acid-inducible gene-I is induced by interleukin-lβ in cultured human gingival fibroblasts.2005

    • Author(s)
      Sakaki H et al.
    • Journal Title

      Oral Microbiol Immunol 20

      Pages: 47-50

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17592063
  • [Journal Article] Retinoic acid-inducible gene-I is induced by interleukin-1 β in cultured human gingival fibroblasts2005

    • Author(s)
      Sakaki H.
    • Journal Title

      Oral Microbiol Immunol 20

      Pages: 47-50

    • Data Source
      KAKENHI-PROJECT-15390606
  • [Journal Article] Retinoic acid-inducible gene-I is induced by interleukin-1β in cultured human gingival fibroblasts2005

    • Author(s)
      Sakaki H.
    • Journal Title

      Oral Microbiol Immunol 20

      Pages: 47-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390606
  • [Journal Article] Retinoic acid-inducible gene-I is induced by interleukin-1β in cultured human gingival fibroblasts.2005

    • Author(s)
      Sakaki H et al.
    • Journal Title

      Oral Microbiol Immunol 20

      Pages: 47-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17592063
  • [Journal Article] Retinoic acid-inducible gene-I is induced by interleukin-18 in cultured human gingival fibroblasts.2005

    • Author(s)
      Sakaki H.
    • Journal Title

      Oral Microbiol Immunol 20

      Pages: 47-50

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390606
  • [Journal Article] Interleukin-1β induces matrix metalloproteinase-1 expression in cultured human gingival fibroblasts : role of cyclooxygenase-2 and prostaglandin E_2.2004

    • Author(s)
      Sakaki H.
    • Journal Title

      Oral Diseases 10

      Pages: 87-93

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390606
  • [Journal Article] Interleukin-1β induces matrix metalloproteinase-1 expression in cultured human gingival fibroblasts : role of cyclooxygenase-2 and prostaglandin E22004

    • Author(s)
      Sakaki H.
    • Journal Title

      Oral Dieases 10

      Pages: 87-93

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390606
  • [Presentation] 骨膜由来細胞はメカニカルストレスに応答しWnt signaling pathwayと BMP signaling pathwayが活性化される2014

    • Author(s)
      伊藤 良平、佐藤 寿、榊 宏剛、久保田 耕世、今 敬生、小林 恒、木村 博人
    • Organizer
      日本口腔科学会
    • Place of Presentation
      東京都新宿区
    • Data Source
      KAKENHI-PROJECT-23592979
  • [Presentation] 進行口腔癌に対する動注化学放射線治療後の放射線性顎骨壊死に関する臨床的検討2011

    • Author(s)
      小林恒、佐藤寿、榊宏剛、久保田耕世、今敬生、中川祥、成田紀彦、木村博人、鄭明源
    • Organizer
      第56回(社)日本口腔外科学会総会・学術大会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2011-10-21
    • Data Source
      KAKENHI-PROJECT-23792309
  • [Presentation] 他:RIG-Iは口腔癌由来細胞株において細胞周期の制御に関与する2011

    • Author(s)
      榊宏剛
    • Organizer
      第56回(社)日本口腔外科学会総会・学術大会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2011-10-21
    • Data Source
      KAKENHI-PROJECT-23792309
  • [Presentation] RIG-Iは口腔癌由来細胞株において細胞周期の制御に関与する2011

    • Author(s)
      榊 宏剛、他
    • Organizer
      第56回(社)日本口腔外科学会総会・学術大会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Data Source
      KAKENHI-PROJECT-23792309
  • [Presentation] WeeklyDocetaxel静注併用放射線療法を施行した高齢者頭頸部癌5症例の検討2011

    • Author(s)
      久保田耕世、榊宏剛、中川祥、成田紀彦、小林恒、木村博人
    • Organizer
      第56回(社)日本口腔外科学会総会・学術大会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2011-10-21
    • Data Source
      KAKENHI-PROJECT-23792309
  • [Presentation] 口腔癌由来細胞株における新規遺伝子RIG-Iを用いた細胞周期制御の検討2010

    • Author(s)
      榊宏剛, 他
    • Organizer
      第55回(社)日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2010-10-16
    • Data Source
      KAKENHI-PROJECT-21791964
  • [Presentation] ケルビズムの1例

    • Author(s)
      榊 宏剛、古舘 健、松宮 朋穂、伊藤 良平、小林 恒 、木村 博人
    • Organizer
      第59回(公社)日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉 幕張メッセ
    • Year and Date
      2014-10-17 – 2014-10-19
    • Data Source
      KAKENHI-PROJECT-26462992
  • [Presentation] Identifying a point mutation in the SH3BP2 gene in cherubism

    • Author(s)
      Hirotaka Sakaki, Ken Furudate, Tomoh Matsumiya, Hisashi Sato, Ryohei Itoh, Wataru Kobayashi, Hiroto Kimura
    • Organizer
      96th Annual Meeting of the American Association of Oral and Maxillofacial Surgeons
    • Place of Presentation
      USA Hawaii
    • Year and Date
      2014-09-08 – 2014-09-13
    • Data Source
      KAKENHI-PROJECT-26462992
  • 1.  KIMURA Hiroto (90142851)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 2.  KUSUMI Akinori (90332494)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 3.  SATOH Hisashi (90311539)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 4.  KUSUMI Tomomi (90322932)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 5.  MATSUMIYA Tomoh (30344592)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 6.  WATARU Kobayashi (50234860)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  NAKAGAWA Hiroshi (00529688)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KUBOTA Kousei (10529689)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 9.  ITO Ryohei (20638902)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 10.  FUKUI Roh (70241479)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  成田 憲司 (50374848)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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