Ohashi Eiji 大橋英治

… Alternative Names

OHASHI Eiji 大橋英治

大橋英治オオハシエイジ

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Researcher Number	90378951
Other IDs	https://orcid.org/0000-0002-1771-5585
Affiliation (Current)	2024: 長浜バイオ大学, バイオサイエンス学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2022: 九州大学, 理学研究院, 講師 2016 – 2020: 九州大学, 理学研究院, 助教 2011: 九州大学, 理学研究院, 助教 2010 – 2011: 九州大学, 大学院・理学研究院, 助教 2006: 京都大学, ウイルス研究所, 助手 2005: 京都大学, ウイルス研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 43050:Genome biology-related / Molecular biology / Genetics/Genome dynamics Except Principal Investigator Molecular biology
Keywords	Principal Investigator タンパク質間相互作用 / チェックポイント / DNA損傷応答 / DNA修復 / DNA損傷 / DNA損傷チェックポイント / 削り込み / 二本鎖DNA切断 / シグナル伝達 / DNA損傷・修復 … More / 試験管内再構築 / 細胞内局在 / 蛋白質問相互作用 / Yファミリー / 相互作用 / DNA複製 / 損傷乗り越え複製 / DNAポリメラーゼ / 突然変異 … More Except Principal Investigator DNAポリメラ―ゼ / PCNA / DNAポリメラーゼ / 複製フォーク / DNA複製 Less

Analysis of reaction network from the loading to unloading of the DNA damage checkpoint clamp 9-1-1 onto DNAPrincipal Investigator
- Principal Investigator
  
  Ohashi Eiji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Kyushu University
Studies on PCNA loading onto newly synthesized leading DNA by Ctf18-RFC/Pole complex
- Principal Investigator
  
  Tsurimoto Toshiki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  Kyushu University
Analysis of the early steps of DNA damage response through 9-1-1/TopBP1 interactionPrincipal Investigator
- Principal Investigator
  
  OHASHI Eiji
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Kyushu University
損傷乗り越え複製酵素複合体のダイナミクスPrincipal Investigator
- Principal Investigator
  
  大橋英治
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019 2018 2017 2016 2012 2011 2010

All Journal Article Presentation Book

[Book] Functions of multiple clamp and clamp-loader complexes in eukaryotic DNA replication in "DNA Replication: From Old Principles to New Discovery” Advances in Experimental Medicine and Biology,2017
- Author(s)
  Ohashi E and Tsurimoto T.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-16H04743
[Journal Article] The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO2023
- Author(s)
  Hara Kodai、Hishiki Asami、Hoshino Takako、Nagata Kiho、Iida Nao、Sawada Yukimasa、Ohashi Eiji、Hashimoto Hiroshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 4 Pages: 103061-103061
- DOI
  10.1016/j.jbc.2023.103061
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H05757, KAKENHI-PROJECT-19K06613, KAKENHI-PROJECT-20H03197
[Journal Article] Specific basic patch‐dependent multimerization of Saccharomyces cerevisiae ORC on single‐stranded DNA promotes ATP hydrolysis.2019
- Author(s)
  Kawakami Hironori、Muraoka Ryuya、Ohashi Eiji、Kawabata Kenta、Kanamoto Shota、Chichibu Takeaki、Tsurimoto Toshiki、Katayama Tsutomu
- Journal Title
  
  Genes to Cells
  
  Volume: 24 Issue: 9 Pages: 608-618
- DOI
  10.1111/gtc.12710
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06613, KAKENHI-PROJECT-17H03656, KAKENHI-PROJECT-17K07338
[Journal Article] Structure of the RAD9-RAD1-HUS1 checkpoint clamp bound to RHINO sheds light on the other side of the DNA clamp2019
- Author(s)
  Hara Kodai、Iida Nao、Tamafune Ryota、Ohashi Eiji、Sakurai Hitomi、Ishikawa Yoshinobu、Hishiki Asami、Hashimoto Hiroshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 4 Pages: 899-904
- DOI
  10.1074/jbc.ac119.011816
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07314, KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-19K06613, KAKENHI-PROJECT-19K07792, KAKENHI-PROJECT-16H05840
[Journal Article] Functions of Multiple Clamp and Clamp-Loader Complexes in Eukaryotic DNA Replication2017
- Author(s)
  Ohashi Eiji、Tsurimoto Toshiki
- Journal Title
  
  Adv Exp Med and Biol
  
  Volume: 1042 Pages: 135-162
- DOI
  10.1007/978-981-10-6955-0_7
- ISBN
  9789811069543, 9789811069550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04743
[Journal Article] Human CTF18-RFC clamp-loader complexed with non-synthesising DNA polymerase ε efficiently loads the PCNA sliding clamp.2017
- Author(s)
  Fujisawa R, Ohashi E, Hirota K, Tsurimoto T
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 印刷中 Issue: 8 Pages: 4550-4563
- DOI
  10.1093/nar/gkx096
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-25440011, KAKENHI-PUBLICLY-16H01314, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-16H04743, KAKENHI-PROJECT-16K12598
[Journal Article] Multiple regulatory roles of Rad9 C-tail in DNA damage responses2017
- Author(s)
  Ohashi E
- Journal Title
  
  J Rare Dis Res Treat
  
  Volume: 2 Pages: 12-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04743
[Journal Article] Rapid purification and characterization of mutant origin recognition complexes in Saccharomyces cerevisiae2016
- Author(s)
  Kawakami, H. (corresponding author), Ohashi, E., Tsurimoto, T., and Katayama, T.
- Journal Title
  
  Front. Microbiol.
  
  Volume: 7 Pages: 521-521
- DOI
  10.3389/fmicb.2016.00521
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18504, KAKENHI-PROJECT-26291004, KAKENHI-PROJECT-16H04743, KAKENHI-PROJECT-25440011
[Journal Article] Conserved interaction of Ctf18-RFC with DNA polymerase ε is critical for maintenance of genome stability in saccharomyces cerevisiae.2016
- Author(s)
  Okimoto H, Tanaka S, Araki H, Ohashi E, Tsurimoto T.
- Journal Title
  
  Genes Cells.
  
  Volume: in press Issue: 5 Pages: 482-491
- DOI
  10.1111/gtc.12356
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25440011, KAKENHI-PROJECT-15K14577, KAKENHI-PUBLICLY-26114714, KAKENHI-PUBLICLY-26114716, KAKENHI-PROJECT-25251005, KAKENHI-PROJECT-24370075, KAKENHI-PLANNED-15H05975, KAKENHI-PROJECT-16H04743
[Journal Article] The vital role of polymerase C and REV1 in mutagenic, but not correct, DNA synthesis across benzo[ a] pyrene-dG and recruitment of polymerase C by REV1 to replicationstalled site2012
- Author(s)
  Hashimoto K, Cho Y, Yang IY, Akagi J, Ohashi E, Tateishi S, de Wind N, Hanaoka F, Ohmori H, and Moriya M.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287 Pages: 9613-9622
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770172
[Journal Article] Casein kinase 2dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Husl-Rad1 complex and TopBP12010
- Author(s)
  Takeishi Y, Ohashi E, Ogawa K, Masai H, Obuse C, and Tsurimoto T.
- Journal Title
  
  Genes Cells
  
  Volume: 15 Pages: 761-771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770172
[Journal Article] Human replicative DNA polymerase d can bypass T-T(6-4) ultraviolet photoproducts on template strands2010
- Author(s)
  Narita T, Tsurimoto T, Yamamoto J, Nishihara K, Ogawa K, Ohashi E, Evans T, Iwai S, Takeda S, and Hirota K.
- Journal Title
  
  Genes Cells
  
  Volume: 15 Pages: 1228-1239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770172
[Journal Article] Stable interaction between the human PCNA loader complex Ctf18-RFC and DNA polymerase e is mediated by the cohesion specific subunits, Ctf18, Dcc1 and Ctf82010
- Author(s)
  Murakami T, Takano R, Takeo S, Taniguchi R, Ogawa K, Ohashi E, and Tsurimoto T.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Pages: 34608-34615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770172
[Presentation] 9-1-1とMRNはDNA二重鎖切断のシグナリングと削り込みに重複した機能を持つ2022
- Author(s)
  達川絢介, 高橋達郎, 大橋英治
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06613
[Presentation] DNA二重鎖切断後の削り込みとチェックポイント活性化の連携機構2021
- Author(s)
  達川絢介、高橋達郎、○大橋英治
- Organizer
  第26回 DNA複製・組換え・修復ワークショップ
- Data Source
  KAKENHI-PROJECT-19K06613
[Presentation] DNA損傷チェックポイントクランプ9-1-1によるATR活性化機構2021
- Author(s)
  達川絢介、橋本博、釣本敏樹、高橋達郎、大橋英治
- Organizer
  第38回染色体ワークショップ・第19回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-19K06613
[Presentation] 9-1-1とMRNは独立した経路でDNA二重鎖切断末端の削り込みを促進する2021
- Author(s)
  ○達川絢介、高橋達郎、大橋英治
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K06613
[Presentation] DNA損傷チェックポイントクランプ9-1-1のリング部分の役割2021
- Author(s)
  達川絢介、橋本博、高橋達郎、○大橋英治
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K06613
[Presentation] 9-1-1とMRNは独立した経路で DNA二重鎖切断末端の削り込みを促進する2021
- Author(s)
  ○達川絢介、高橋達郎、大橋英治
- Organizer
  第39回染色体ワークショップ・第20回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-19K06613
[Presentation] チェックポイントセンサー9-1-1とMRNによる二重鎖切断後の損傷応答制御2020
- Author(s)
  達川絢介、釣本敏樹、高橋達郎、大橋英治
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06613
[Presentation] Rad9 C-terminal tail intramolecularly binds to the Rad9-Hus1-Rad1 checkpoint clamp and regulates the binding of DNA damage response proteins2018
- Author(s)
  Eiji Ohashi, Naoya Iwata, Kensuke Tatsukawa, Toshiki Tsurimoto
- Organizer
  3R & 3C Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04743
[Presentation] 複製染色体でのPCNAの動態制御2018
- Author(s)
  釣本敏樹　藤澤遼　河添好孝　大橋英治　高橋達郎
- Organizer
  第12回エピジェネティクス研究会年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04743
[Presentation] CTF18-RFC complexed with DNA polymerase ε actively loads PCNA to maintain the efficient DNA synthesis2017
- Author(s)
  Tsurimoto T, Fujisawa R, Ohashi E
- Organizer
  Cold Spring Harbor Laboratory Meeting “Eukaryotic DNA Replication & Genome Maintenance”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04743
[Presentation] チェックポイントクランプ9-1-1におけるPCNA様リング構造とRad9 C-tail間の分子内結合領域の解析2017
- Author(s)
  達川絢介、岩田直也、大橋英治、釣本敏樹
- Organizer
  Consortium of Biological Sciences 2017　(第40回日本分子生物学会年会)
- Data Source
  KAKENHI-PROJECT-16H04743
[Presentation] Rad9 C末端による9-1-1クランプへの蛋白質結合の制御2017
- Author(s)
  大橋英治、岩田直也、釣本敏樹
- Organizer
  第34回染色体ワークショップ・第15回核ダイナミクス研究会合同
- Place of Presentation
  木更津市
- Year and Date
  2017-01-11
- Data Source
  KAKENHI-PROJECT-16H04743
[Presentation] 9-1-1チェックポイントクランプの分子内結合によるp21と9-1-1の結合制御2017
- Author(s)
  大橋英治、岩田直也、達川絢介、釣本敏樹
- Organizer
  第24回 DNA複製・組換え・修復ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-16H04743
[Presentation] Intramolecular binding of Rad9 C-terminal tail to Rad9-Hus1-Rad1 core ring structure regulates the binding of DNA damage response proteins.2017
- Author(s)
  Eiji Ohashi, Naoya Iwata, Kensuke Tatsukawa, Toshiki Tsurimoto
- Organizer
  Cold Spring Harbor Laboratory Meeting “Eukaryotic DNA Replication & Genome Maintenance”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04743
[Presentation] Rad9-Hus1-Rad1クランプのRad9 C-tailを介したDNA複製ストレス応答の制御機構2017
- Author(s)
  大橋英治、岩田直也、達川絢介、釣本敏樹
- Organizer
  Consortium of Biological Sciences 2017　(第40回日本分子生物学会年会）
- Invited
- Data Source
  KAKENHI-PROJECT-16H04743
[Presentation] DNA複製とPCNAダイナミクス2017
- Author(s)
  釣本敏樹　藤澤遼　大橋英治高橋達郎
- Organizer
  Consortium of Biological Sciences 2017　(第40回日本分子生物学会年会)
- Invited
- Data Source
  KAKENHI-PROJECT-16H04743
[Presentation] Polεを足場にしたCtf18-RFCによる動的PCNAローディング2016
- Author(s)
  釣本敏樹　藤澤遼　大橋英治
- Organizer
  第39回日本分子生物学会年会シンポジウム
- Place of Presentation
  横浜市
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-16H04743
[Presentation] Intramolecular folding of Rad9 C-terminal tail in the Rad9-Hus1-Rad1 checkpoint clamp regulates its interaction with DNA damage response proteins.2016
- Author(s)
  Ohashi E, Iwata N, Tsurimoto T
- Organizer
  The 10th 3R Symposium
- Place of Presentation
  Matsue, Japan
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04743
[Presentation] Ctf18-RFC bound to Polε loads PCNA efficiently.2016
- Author(s)
  Fujisawa R, Ohashi E, Hirota K, Tsurimoto T
- Organizer
  The 10th 3R Symposium
- Place of Presentation
  Matsue, Japan
- Year and Date
  2016-11-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04743
[Presentation] PCNA結合蛋白質のRad9-Hus1-Rad1リングとの結合メカニズム2016
- Author(s)
  大橋英治、岩田直也、釣本敏樹
- Organizer
  第39回日本分子生物学会年会シンポジウム
- Place of Presentation
  横浜市
- Year and Date
  2016-12-02
- Invited
- Data Source
  KAKENHI-PROJECT-16H04743
[Presentation] Roles of the human 9-1-1/TopBP1 interaction for cellular DNA damage responses2011
- Author(s)
  大橋英治, ら
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜(招待講演)
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22770172
[Presentation] Roles of the 9-1-1/TopBP1 interaction for DNA damage responses in human cells2011
- Author(s)
  Ohashi E, Takeishi Y, Ueda S, and Tsurimoto T.
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22770172
[Presentation] ヒト細胞内でのDNA損傷応答における9-1-1/TopBP1相互作用の役割2011
- Author(s)
  大橋英治, ら
- Organizer
  DNA複製・組換え・ゲノム安定性制御ワークショップ
- Place of Presentation
  サンピア福岡
- Year and Date
  2011-10-25
- Data Source
  KAKENHI-PROJECT-22770172
[Presentation] ヒト細胞内でのDNA損傷応答における9-1-1/TopBP1相互作用の役割2011
- Author(s)
  大橋英治、武石幸容、上田聡、釣本敏樹
- Organizer
  第21回DNA複製・組換え・ゲノム安定性制御ワークショップ
- Place of Presentation
  福津
- Year and Date
  2011-10-25
- Data Source
  KAKENHI-PROJECT-22770172
[Presentation] DNA損傷応答における9-1-1/TopBP1相互作用の役割2011
- Author(s)
  大橋英治, ら
- Organizer
  遺伝研「ゲノム損傷応答研究会」
- Place of Presentation
  国立遺伝学研究所(招待講演)
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-22770172
[Presentation] Roles of the human 9-1-1/TopBP1 interaction for DNA damage responses2011
- Author(s)
  Ohashi E, Takeishi Y, Ueda S, and Tsurimoto T.
- Organizer
  Cold Spring Larbor Laboratory Meeting on" Eukaryotic DNA replication and genome maintenance
- Place of Presentation
  CSH, NY, USA
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-22770172
[Presentation] Chromatin association of human Rad9-Hus1-Rad1 complex is dependent on TopBP1 but not on the interaction with TopBP12010
- Author(s)
  大橋英治, ら
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22770172
[Presentation] Chromatin association of human Rad9Husl-Radl complex is dependent on TopBP1 but not on the interaction with TopBP12010
- Author(s)
  Ohashi E, Takeishi Y, Ueda S, and Tsurimoto T.
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22770172

1. TSURIMOTO Toshiki (30163885)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
2. 原幸大

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 川上広宣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 廣田耕志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 橋本博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohashi Eiji 大橋 英治

OHASHI Eiji 大橋 英治

大橋 英治 オオハシ エイジ

Research Projects

Research Products

Co-Researchers

Analysis of reaction network from the loading to unloading of the DNA damage checkpoint clamp 9-1-1 onto DNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on PCNA loading onto newly synthesized leading DNA by Ctf18-RFC/Pole complex

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the early steps of DNA damage response through 9-1-1/TopBP1 interactionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

損傷乗り越え複製酵素複合体のダイナミクスPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Functions of multiple clamp and clamp-loader complexes in eukaryotic DNA replication in "DNA Replication: From Old Principles to New Discovery” Advances in Experimental Medicine and Biology,2017

Author(s)

Publisher

Data Source

[Journal Article] The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Specific basic patch‐dependent multimerization of Saccharomyces cerevisiae ORC on single‐stranded DNA promotes ATP hydrolysis.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of the RAD9-RAD1-HUS1 checkpoint clamp bound to RHINO sheds light on the other side of the DNA clamp2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functions of Multiple Clamp and Clamp-Loader Complexes in Eukaryotic DNA Replication2017

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Human CTF18-RFC clamp-loader complexed with non-synthesising DNA polymerase ε efficiently loads the PCNA sliding clamp.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multiple regulatory roles of Rad9 C-tail in DNA damage responses2017

Author(s)

Journal Title

Data Source

[Journal Article] Rapid purification and characterization of mutant origin recognition complexes in Saccharomyces cerevisiae2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conserved interaction of Ctf18-RFC with DNA polymerase ε is critical for maintenance of genome stability in saccharomyces cerevisiae.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The vital role of polymerase C and REV1 in mutagenic, but not correct, DNA synthesis across benzo[ a] pyrene-dG and recruitment of polymerase C by REV1 to replicationstalled site2012

Author(s)

Journal Title

Data Source

[Journal Article] Casein kinase 2dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Husl-Rad1 complex and TopBP12010

Author(s)

Ohashi Eiji 大橋英治

OHASHI Eiji 大橋英治

大橋英治オオハシエイジ