Mano Toshiaki 真野敏昭

… Alternative Names

MANO Toshiaki 真野敏昭

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Researcher Number	90379165
Affiliation (Current)	2025: 兵庫医科大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2014: 兵庫医科大学, 医学部, 准教授 2011 – 2013: 大阪大学, 医学部附属病院, 講師 2010: 大阪大学, 医学部・附属病院, 講師 2005 – 2009: 大阪大学, 医学部附属病院, 講師 2008: 大阪大学, 医学部付属病院, 講師
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Medical systems
Keywords	Principal Investigator 腎血流ドプラ / 機能的腎予備力 / 心不全 / 腎予備力 / 心腎連関 Except Principal Investigator 心不全 / 食塩感受性 / 拡張機能 / Diabetes Mellitus / Ultrasound … More / Remodeling / Myocardial Fibrosis / Cardiac Hypertrophy / 糖尿病 / 循環器・高血圧 / 拡張不全 / カルニチン / 内因性ステロイド / 超音波 Less

Impact of Carnitine on Heart Failure with Preserved Ejection Fraction
- Principal Investigator
  
  SAKATA Yasushi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The mechanism of cardio-renal interaction in heart failure-the approach from functional renal reserve-Principal Investigator
- Principal Investigator
  
  MANO Toshiaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The role of salt sensitivity in the development of heart failure with preserved ejection fraction and the relation of intrinsic steroids
- Principal Investigator
  
  SAKATA Yasushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
new method to evaluate diastolicfunction using echocardiography
- Principal Investigator
  
  SAKATA Yasushi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical systems
- Research Institution
  Osaka University
Ultrasound imaging for tissue characterization to assess cardiovascular involvement in diabetes
- Principal Investigator
  
  MASUYAMA Tohru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical systems
- Research Institution
  Hyogo Medical University

All 2014 2013 2012 2011 2008 2007

All Journal Article Presentation Patent

[Journal Article] Endovascular Aortic Repair Increases Vascular Stiffness and Alters Cardiac Structure and Function.2014
- Author(s)
  93. Takeda Y, Sakata Y*, Ohtani T, Tamaki S, Omori Y, Tsukamoto Y, Aizawa Y, Shimamura K, Shirakawa Y, Kuratani T, Sawa Y, Yamamoto K, Mano T, Komuro I
- Journal Title
  
  Circ J
  
  Volume: 78 Pages: 322-328
- NAID
  130003382224
- Data Source
  KAKENHI-PROJECT-24591049
[Journal Article] A Novel Heart Failure Mice Model of Hypertensive Heart Disease by Angiotensin II Infusion, Nephrectomy, and Salt Loading2013
- Author(s)
  Tsukamoto Y, Komuro I（15人中15番目）
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 305 Issue: 11 Pages: 1658-1667
- DOI
  10.1152/ajpheart.00349.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229010, KAKENHI-PLANNED-23106003, KAKENHI-PROJECT-23591042
[Journal Article] Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction.2013
- Author(s)
  Tamaki S, Komuro I (19人中19番目）
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 7 Pages: e68893-e68893
- DOI
  10.1371/journal.pone.0068893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229010, KAKENHI-PLANNED-23106003, KAKENHI-PROJECT-23591042
[Journal Article] L-Carnitine prevents the development of ventricular fibrosis and heart failure with preserved ejection fraction in hypertensive heart disease2012
- Author(s)
  Omori Y, Ohtani T, Sakata Y, Mano T, Takeda Y, Tamaki S, Tsukamoto Y, Kamimura D, Aizawa Y, Miwa T, Komuro I, Soga T, Yamamoto K.
- Journal Title
  
  J Hypertens
  
  Volume: 30 Issue: 9 Pages: 1834-44
- DOI
  10.1097/hjh.0b013e3283569c5a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591042
[Journal Article] Ca2+ Entry Mode of Na+/ Ca2+ Exchanger as A New Therapeutic Target for Heart Failure with Preserved Ejection Fraction2011
- Author(s)
  Kamimura D, Ohtani T, Sakata Y, Mano T, Tkaeda Y, Tamaki S, Omori Y, Tshkamoto Y, Furutani K, Komiyama Y, Yoshika M, Takahashi H, Matsuda T, Baba A, Umemura S, Miwa T, Komuro I, Yamamoto K.
- Journal Title
  
  Eur Heart J
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590893
[Journal Article] Ca2+ entry mode of Na+/Ca2+ exchanger as a new therapeutic target for heart failure with preserved ejection fraction2011
- Author(s)
  Kamimura D, Ohtani T, Sakata Y, Mano T, Takeda Y, Tamaki S, Omori Y, Tsukamoto Y, Furutani K, Komiyama Y, Yoshika M, Takahashi H, Matsuda T, Baba A, Umemura S, Miwa T, Komuro I, Yamamoto K
- Journal Title
  
  European Heart Journal
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590893
[Journal Article] Beneficial effects of bisoprolol on the survival of hypertensive diastolic heart failure model rats2008
- Author(s)
  Nishio M, Sakata Y, Mano T, Ohtani T, Takeda Y, Miwa T, Hori M, Masuyama T, Kondo T, Yamamoto K
- Journal Title
  
  Eur J Heart Fail
  
  Pages: 446-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500420
[Journal Article] Noninvasive Assessment of Diastolic Function in Subjects with Preserved Ejection Fraction : Usefulness of Color Kinetic Imaging2008
- Author(s)
  Takeda Y, Sakata Y, Mano T, Nishio M, Ohtani T, Hori M, Masuyama T, Yamamoto K
- Journal Title
  
  J Card Fail 7
  
  Pages: 569-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500420
[Journal Article] Difference of Clinical Characteristics between Hypertensive Patients with and without Diastolic Heart Failure : Role of Diastolic Dysfunction and Renal Insufficiency2008
- Author(s)
  Nishio M, Sakata Y, Mano T, Ohtani T, Takeda Y, Hori M, Yamamoto K
- Journal Title
  
  Hypertens Res 31
  
  Pages: 1865-72
- NAID
  10024827442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500420
[Journal Article] Elevated Cardiac Tissue Level of Aldosterone andMineralocorticoid Receptor in Diastolic Heart Failure : Beneficial Effects of Mineralocorticoid Receptor Blocker2007
- Author(s)
  Ohtani T, Ohta M, Yamamoto K, Mano T, Sakata Y, Nishio M, Takeda Y, Yoshida J, Miwa T, Okamoto M, Masuyama T, Nonaka Y, Hori M
- Journal Title
  
  Am J Physiol Heart Circ Physiol 292
  
  Pages: 946-956
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500420
[Journal Article] Elevated Cardiac Tissue Level of Aldosterone and Mineralocorticoid Receptor in Diastolic Heart Failure: Beneficial Effects of Mineralocorticoid Receator Blocker.2007
- Author(s)
  Ohtani T, Ohta M, Yamamoto K, Mano T, Sakata Y, et. al.
- Journal Title
  
  Am J Physiol Heart Circ Physiol. 292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500420
[Journal Article] Therapeutic effects of angiotensin II type 1 receptor blocker at an advanced stage of hypertensive diastolic heart failure2007
- Author(s)
  Nishio M, Sakata Y, Mano T, Yoshida J, Ohtani T, Takeda Y, Miwa T, Masuyama T, Yamamoto K, Hori M
- Journal Title
  
  J Hypertens 25
  
  Pages: 455-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500420
[Patent] 拡張性心不全を治療、診断するための組成物およびその利用2014
- Inventor(s)
  真野敏昭坂田泰史玉置俊介萩原圭祐
- Industrial Property Rights Holder
  真野敏昭坂田泰史玉置俊介萩原圭祐
- Industrial Property Rights Type
  特許
- Filing Date
  2014-01-17
- Overseas
- Data Source
  KAKENHI-PROJECT-23591042
[Presentation] Interleukin-16 is associated with diastolic dysfunction, promotes cardiac fibrosis and accelerates myocardial stiffening in heart failure with preserved ejection fraction2013
- Author(s)
  真野敏昭、玉置俊介
- Organizer
  日本心不全学会学術集会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-23591042

1. SAKATA Yasushi (00397671)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
2. YAMAMOTO Kazuhiro (90303966)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
3. OHTANI Tomohito (30623897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. MASUYAMA Tohru (70273670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TSUJINO Takeshi (90283887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKAO Shinji (80309450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YUBA Masao (60351821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAKATA Yasusi (90379206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小室一成

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Mano Toshiaki 真野 敏昭

MANO Toshiaki 真野 敏昭

Research Projects

Research Products

Co-Researchers

Impact of Carnitine on Heart Failure with Preserved Ejection Fraction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of cardio-renal interaction in heart failure-the approach from functional renal reserve-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of salt sensitivity in the development of heart failure with preserved ejection fraction and the relation of intrinsic steroids

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

new method to evaluate diastolicfunction using echocardiography

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ultrasound imaging for tissue characterization to assess cardiovascular involvement in diabetes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Endovascular Aortic Repair Increases Vascular Stiffness and Alters Cardiac Structure and Function.2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] A Novel Heart Failure Mice Model of Hypertensive Heart Disease by Angiotensin II Infusion, Nephrectomy, and Salt Loading2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] L-Carnitine prevents the development of ventricular fibrosis and heart failure with preserved ejection fraction in hypertensive heart disease2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ca2+ Entry Mode of Na+/ Ca2+ Exchanger as A New Therapeutic Target for Heart Failure with Preserved Ejection Fraction2011

Author(s)

Journal Title

Data Source

[Journal Article] Ca2+ entry mode of Na+/Ca2+ exchanger as a new therapeutic target for heart failure with preserved ejection fraction2011

Author(s)

Journal Title

Data Source

[Journal Article] Beneficial effects of bisoprolol on the survival of hypertensive diastolic heart failure model rats2008

Author(s)

Journal Title

Data Source

[Journal Article] Noninvasive Assessment of Diastolic Function in Subjects with Preserved Ejection Fraction : Usefulness of Color Kinetic Imaging2008

Author(s)

Journal Title

Data Source

[Journal Article] Difference of Clinical Characteristics between Hypertensive Patients with and without Diastolic Heart Failure : Role of Diastolic Dysfunction and Renal Insufficiency2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Elevated Cardiac Tissue Level of Aldosterone andMineralocorticoid Receptor in Diastolic Heart Failure : Beneficial Effects of Mineralocorticoid Receptor Blocker2007

Author(s)

Journal Title

Data Source

Mano Toshiaki 真野敏昭

MANO Toshiaki 真野敏昭

[Patent] 拡張性心不全を治療、診断するための組成物およびその利用2014