Shimizu Mikiko 清水美貴子

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SHIMIZU Mikiko 清水美貴子

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Researcher Number	90396391
Other IDs
Affiliation (Current)	2025: 就実大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 就実大学, 薬学部, 教授 2018 – 2019: 青森大学, 薬学部, 教授 2016 – 2017: 慶應義塾大学, 薬学部(芝共立), 講師 2008 – 2015: Keio University, 薬学部, 講師 2007: Kyoritsu University of Pharmacy, 薬学部, 講師
Review Section/Research Field	Principal Investigator Environmental pharmacy / Basic Section 38050:Food sciences-related / Environmental and hygienic pharmacy Except Principal Investigator Basic Section 90140:Medical technology assessment-related
Keywords	Principal Investigator プロバイオティクス / 薬物動態 / メトトレキセート / 関節リウマチ / メトトレキサート / 脂質異常症 / 薬物輸送担体 / 薬物代謝酵素 / 消化管 / 医療経済 … More / methotrexate / microbiome / microbiome therapy / リウマチ / Methotrexate / 炎症性疾患 / 副作用軽減 / 細胞障害 / サイトカイン / 間接リウマチ / 炎症性腸疾患 / コレステロール / 脂質異常症治療薬 / メタアナリシス / 小腸 … More Except Principal Investigator 貼付剤 / 関節リウマチ / 自己免疫疾患 / イオントフォレーシス / メトトレキサート Less

Development of a novel methotrexate administration method for rheumatoid arthritis patients using iontophoresis
- Principal Investigator
  
  橋口正行
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90140:Medical technology assessment-related
- Research Institution
  Jikei University School of Medicine
Microbiome therapy for rheumatic diseasesPrincipal Investigator
- Principal Investigator
  
  清水美貴子
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Shujitsu University
  Aomori University
Prevention and treatment of inflammatory diseases: control of pharmacokinetics with probioticsPrincipal Investigator
- Principal Investigator
  
  Mikiko Shimizu
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Aomori University
  Keio University
Evaluation of the clinical usefulness of probiotics for the prevention and treatment of lifestyle-related diseasePrincipal Investigator
- Principal Investigator
  
  SHIMIZU MIKIKO
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Keio University
Effects of probiotics on human intestinal absorption and metabolism of drugs.Principal Investigator
- Principal Investigator
  
  SHIMIZU Mikiko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Keio University
  Kyoritsu University of Pharmacy

[Journal Article] Pharmacokinetics of hydroxychloroquine in Japanese systemic lupus erythematosus patients with renal impairment2023
- Author(s)
  Shimizu Mikiko、Furudate Sumito、Nagai Yoshiki、Shimada Kota、Ohshima Miho、Setoguchi Keigo、Hashiguchi Masayuki、Yokogawa Naoto
- Journal Title
  
  Modern Rheumatology
  
  Volume: 33 Issue: 5 Pages: 953-960
- DOI
  10.1093/mr/roac113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05914
[Journal Article] Comparison of Clinical Equivalence of Infliximab and its Biosimilar Combinations with Methotrexate in the Treatment of Rheumatoid Arthritis2022
- Author(s)
  Shimizu M, Mizutani E, Shiga T, Hashiguchi M
- Journal Title
  
  Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
  
  Volume: 53 Issue: 2 Pages: 15-24
- DOI
  10.3999/jscpt.53.15
- ISSN
  0388-1601, 1882-8272
- Year and Date
  2022-03-31
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05914
[Journal Article] Meta-Analysis Comparing Bivalirudin Versus. Unfractionated Heparin in Adult Patients With Extracorporeal Membrane Oxygenation2022
- Author(s)
  Kido Kazuhiko、Kabulski Galen M.、Szymanski Thomas W.、Shiga Tsuyoshi、Shimizu Mikiko、Hashiguchi Masayuki
- Journal Title
  
  Journal of Pharmacy Practice
  
  Volume: － Issue: 2 Pages: 429-434
- DOI
  10.1177/08971900221143406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05914
[Journal Article] Meya-analysis comparing inappropriately low dose versus standard dose of direct oral anticoagulants in patients with atrial fibrillation2022
- Author(s)
  Kido K, Shimizu M, Shiga T, Hashiguchi M
- Journal Title
  
  Journal of the American Pharmacists Association
  
  Volume: 62 Issue: 2 Pages: 487-495
- DOI
  10.1016/j.japh.2021.10.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05914
[Journal Article] Early-Onset Hydroxychloroquine Retinopathy and a Possible Relationship to Blood Levels: Comment on the Article by Petri et al.2021
- Author(s)
  Yokogawa N, Ohno-Tanaka A, Hashiguchi M, Shimizu M, Ozawa H, Ueno S, Shinoda K, Browning DJ.
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: 73 Issue: 2 Pages: 358-359
- DOI
  10.1002/art.41497
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11430, KAKENHI-PROJECT-19K05914
[Journal Article] Ocular findings in Japanese patients with hydroxychloroquine retinopathy developing within 3 years of treatment.2021
- Author(s)
  Ozawa H, Ueno S, Ohno-Tanaka A, Sakai T, Hashiguchi M, Shimizu M, Fujinami K, Ahn SJ, Kondo M, Browning DJ, Shinoda K, Yokogawa N.
- Journal Title
  
  Jpn J Ophthalmol.
  
  Volume: 65 Issue: 4 Pages: 472-481
- DOI
  10.1007/s10384-021-00841-9
- NAID
  40022621225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11430, KAKENHI-PROJECT-18H02954, KAKENHI-PROJECT-19K05914
[Journal Article] Meta-analysis comparing direct oral anticoagulants versus vitamin K antagonists in patients with left ventricular thrombus2021
- Author(s)
  Kido K, Ghaffar YA, Lee JC, Bianco C, Shimizu M, Shiga T, Hashiguchi M.
- Journal Title
  
  PLoS One
  
  Volume: - Issue: 6 Pages: 1-10
- DOI
  10.1371/journal.pone.0252549
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05914
[Journal Article] Meta-Analysis Comparing Direct Oral Anticoagulants Versus Warfarin in Morbidly Obese Patients With Atrial Fibrillation2020
- Author(s)
  Kido Kazuhiko、Shimizu Mikiko、Shiga Tsuyoshi、Hashiguchi Masayuki
- Journal Title
  
  The American Journal of Cardiology
  
  Volume: 126 Pages: 23-28
- DOI
  10.1016/j.amjcard.2020.03.048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05914
[Journal Article] Factors contributing to the systemic clearance of infliximab with long-term administration in Japanese patients with Crohn’s disease: Analysis using population pharmacokinetics2020
- Author(s)
  Matsuoka Katsuyoshi、Hamada Shunsuke、Shimizu Mikiko、Nanki Kosaku、Mizuno Shinta、Kiyohara Hiroki、Arai Mari、Sugimoto Shinya、Iwao Yasushi、Ogata Haruhiko、Hisamatsu Tadakazu、Nagauma Makoto、Kanai Takanori、Mochizuki Mayumi、Hashiguchi Masayuki
- Journal Title
  
  Int. Journal of Clinical Pharmacology and Therapeutics
  
  Volume: 58 Issue: 02 Pages: 89-102
- DOI
  10.5414/cp203569
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05914, KAKENHI-PROJECT-18KK0246, KAKENHI-PROJECT-15K08045
[Journal Article] Network Meta-Analysis Comparing Apixaban Versus Rivaroxaban in Morbidly Obese Patients With Atrial Fibrillation2020
- Author(s)
  Kido Kazuhiko、Shimizu Mikiko、Shiga Tsuyoshi、Hashiguchi Masayuki
- Journal Title
  
  The American Journal of Cardiology
  
  Volume: 134 Pages: 160-161
- DOI
  10.1016/j.amjcard.2020.09.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05914
[Journal Article] Long‐term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine2019
- Author(s)
  Akiyama Shintaro、Takenaka Kento、et al
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 34 Issue: 10 Pages: 1751-1757
- DOI
  10.1111/jgh.14693
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-19K05914, KAKENHI-PROJECT-18KK0246, KAKENHI-PROJECT-15K08045, KAKENHI-PROJECT-17K09370
[Journal Article] Comparing torsemide versus furosemide in patients with heart failure: A meta-analysis.2019
- Author(s)
  Kido K, Shimizu M, Hashiguchi M
- Journal Title
  
  J. Am Pharm Assoc (2003)
  
  Volume: 59(3) Issue: 3 Pages: 432-438
- DOI
  10.1016/j.japh.2019.01.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08045
[Journal Article] Risk factors for abnormal hepatic enzyme elevation by methotrexate treatment in patients with rheumatoid arthritis: a hospital based-cohort study.2018
- Author(s)
  Hakamata J, Hashiguchi M, Kaneko Y, Yamaoka K, Shimizu M, Maruyama J, Takeuchi T, Mochizuki M.
- Journal Title
  
  Modern Rheumatology
  
  Volume: 2 Issue: 4 Pages: 1-10
- DOI
  10.1080/14397595.2017.1414765
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08045
[Journal Article] Risk factors for Hyperuricemia with HMG-CoA reductase inhibitors identified using a postmarketing surveillance database in Japan.2018
- Author(s)
  Hashiguchi M, Hakamata J, Shimizu M, Maruyma J, Shiga T, Mochizuki M
- Journal Title
  
  Jap J Clin Pharmacol Ther
  
  Volume: 49(4) Pages: 145-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08045
[Journal Article] Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanese patients with Crohn’s disease.2018
- Author(s)
  Matsuoka K, Hamada S, Shimizu M, Nanki K, Mizuno S, Kiyohara H, Arai M, Sugimoto S, Iwao Y, Ogata H, Hisamatsu T, Naganuma M, Kanai T, Mochizuki M, Hashiguchi M
- Journal Title
  
  PLoS One
  
  Volume: 13(10) Pages: 1-10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08045
[Journal Article] Risk Factor for Diabetes Mellitus and High Blood GlucoseWith HMG-CoA Reductase Inhibitors Using a Postmarketing Surveillance Database in Japan.2018
- Author(s)
  Hashiguchi M, Maruyma J, Shimizu M, Takahashi D, Shiga T
- Journal Title
  
  Clinical Pharmacology in Drug Development
  
  Volume: 7(8) Issue: 8 Pages: 800-810
- DOI
  10.1002/cpdd.444
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08045
[Journal Article] Risk factors for rhabdomyolysis with HMG-CoA reductase inhibitors identified using a postmarketing surveillance database in Japan.2018
- Author(s)
  Hashiguchi M, Hakamata J, Shimizu M, Maruyma J, Shiga T, Mochizuki M
- Journal Title
  
  Int J Clin Pharmacol Ther
  
  Volume: 56(7) Issue: 07 Pages: 310-320
- DOI
  10.5414/cp203237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08045
[Journal Article] Factors Predicting the Therapeutic Response to Methotrexate in Japanese Patients with Rheumatoid Arthritis: A Hospital-Based Cohort Study2018
- Author(s)
  Hakamata J, Kaneko Y, Shimizu M, Yamaoka K, Maruyama J, Takeuchi T, Mochizuki M, Hashiguchi M
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 9 Pages: 1414-1422
- DOI
  10.1248/bpb.b18-00247
- NAID
  130007479889
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2018-09-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08045
[Journal Article] Ethnic and gender differences in genetic polymorphisms of tumor necrosis factor (TNF)-α in a Japanese population.2017
- Author(s)
  Hakanmada J, Hashiguchi M, Thuru T, Tanaka T, Irie S, Shimizu M, Mochizuki M.
- Journal Title
  
  Jpn J Clin Pharmacol Ther
  
  Volume: 48（2） Pages: 21-21
- NAID
  130005606230
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08045
[Journal Article] Ethnic and gender differences in genetic polymorphisms of tumor necrosis factor (TNF)-α in a Japanese population.2017
- Author(s)
  Hakamata J, Hashiguchi M, Tsuru T, Tanaka T, Irie S, Shimizu M, Mochizuki M.
- Journal Title
  
  Jpn J Clin Pharmacol Ther
  
  Volume: 48 Pages: 21-26
- NAID
  130005606230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08045
[Journal Article] Genetic polymorphisms of enzyme proteins and transporters related to methotrexate response and pharmacokinetics in a Japanese population.2016
- Author(s)
  Hashiguchi M, Shimizu M, Hakamata J, Tsuru T, Tanaka T, Suzaki M, Miyawaki K, Chiyoda T, Takeuchi O, Hiratsuka J, Irie S, Maruyama J, Mochizuki M.
- Journal Title
  
  J Pharm Health Care Sci.
  
  Volume: 2 (35) Issue: 1
- DOI
  10.1186/s40780-016-0069-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08045
[Journal Article] Preliminary study for predicting better methotrexate efficacy in Japanese patients with rheumatoid arthritis.2016
- Author(s)
  Hashiguchi M, Tsuru T, Miyawaki K, Suzaki M, Hakamata J, Shimizu M, Irie S, Mochizuki M.
- Journal Title
  
  J Pharm Health Care Sci
  
  Volume: 2（13） Issue: 1
- DOI
  10.1186/s40780-016-0047-6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08045
[Journal Article] Sex Differences in mRNA Expression of Reduced Folate Carrier-1, Folypolyformyl Glutamate Synthase, And γ-Glutamyl Hydrolase in a Healthy Japanese Population.2016
- Author(s)
  Hashiguchi M, Tanaka T, Shimizu M, Tsuru T, Chiyoda T, Miyawaki K, Irie S, Takeuchi O, Hakamata J, Mochizuki M.
- Journal Title
  
  J Clin Pharmacol
  
  Volume: 56（12） Issue: 12 Pages: 1563-1569
- DOI
  10.1002/jcph.760
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08045
[Journal Article] Factors Affecting the Timing of Signal Detection of Adverse Drug Reactions.2015
- Author(s)
  Hashiguchi M, Imai S, Uehara K, Maruyama J, Shimizu M, Mochizuki M.
- Journal Title
  
  PLoS One
  
  Volume: 10（12）e0144263 Issue: 12 Pages: e0144263-e0144263
- DOI
  10.1371/journal.pone.0144263
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08045
[Journal Article] Quantitation of pilsicainide in microscale samples of human biological fluids using liquid chromatography-tandem mass spectrometry2015
- Author(s)
  Shimizu M, Hashiguchi M, Shiga T, Nakamura K, Tamura H, Mochizuki M.
- Journal Title
  
  J Chromatogr B
  
  Volume: 15 Pages: 172-179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590122
[Journal Article] Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals.2015
- Author(s)
  Shimizu M*, Hashiguchi M, Shiga T, Tamura HO, Mochizuki M.
- Journal Title
  
  PLoS One
  
  Volume: 10（10）e0139795 Issue: 10 Pages: e0139795-e0139795
- DOI
  10.1371/journal.pone.0139795
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08045
[Journal Article] Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia.2015
- Author(s)
  Masayuki Hashiguchi, Yuriko Ohta, Mikiko Shimizu, Junya Maruyama and Mayumi Mochizuki*
- Journal Title
  
  Journal of Pharmaceutical Health Care and Sciences
  
  Volume: １・14 Issue: 1
- DOI
  10.1186/s40780-015-0014-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08045
[Journal Article] Lack of pharmacokinetic interaction between pilsicainide and rifampicin in healthy volunteers.2013
- Author(s)
  Shiga T., Hashiguchi H., Nakamura K., Shimizu M., Shimizu K., Suzuki A., Mochizuki M., Hagiwara N.
- Journal Title
  
  Jpn. J. Clin. Pharmacol. Ther.
  
  Volume: 44 Pages: 301-305
- NAID
  10031190916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590122
[Journal Article] Relationship between genetic polymorphism and mRNA expression of dihydrofolate reductase enzyme in a healthy Japanese population.2013
- Author(s)
  Hashiguchi M., Shimizu M., Takeuchi O., Hayashi T., Inoue S., Tanaka T., Tsuru T., Irie S., Kurokawa .T, Mochizuki M.
- Journal Title
  
  Jpn. J. Clin. Pharmacol. Ther.
  
  Volume: 44 Pages: 185-192
- NAID
  10031177985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590122
[Journal Article] 脂質異常症治療薬とプロバイオティクスとの相互作用に関する研究.2012
- Author(s)
  清水美貴子
- Journal Title
  
  Recent Advances in clinical Pharmacology
  
  Volume: 33 Pages: 64-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590122
[Presentation] Comparison of Clinical Equivalence of Infliximab and its Biosimilar Combinations with Methotrexate in the Treatment Rheumatoid Arthritis．2023
- Author(s)
  清水　美貴子
- Organizer
  2023年度臨床薬理研究振興財団賞・受賞講演
- Data Source
  KAKENHI-PROJECT-19K05914
[Presentation] Comparing Inappropriately Low Dose versus Standard Dose of Direct Oral Anticoagulants in Patients with Atrial Fibrillation: A Meta-analysis2021
- Author(s)
  〇Kido K, Hashiguchi M, Shimizu M, Shiga T
- Organizer
  American College of Clinical Pharmacy Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05914
[Presentation] 青森県におけるフォーミュラリー導入の意義と適用方法の検討2021
- Author(s)
  〇小坂太一、清水美貴子
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K05914
[Presentation] メトトレキサートを用いた関節リウマチ療法におけるインフリキシマブおよびバイオシミラー併用投与の有用性の比較2020
- Author(s)
  〇清水美貴子、水谷栄祐、松尾美奈子、橋口正行
- Organizer
  第41回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-19K05914
[Presentation] Pharmacokinetics of hydroxychloroquine in systemic lupus erythematosus patients with renal impairment2019
- Author(s)
  Yokogawa N、Hashiguchi M、Nagai Y、Shimada K、Sugii S、Ohshima M、Setoguchi K、Shimizu M
- Organizer
  ACR 2019 (American College of Rheumatology)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08045
[Presentation] Pharmacokinetics of hydroxychloroquine in systemic lupus erythematosus patients with renal impairment2019
- Author(s)
  Yokogawa N、Hashiguchi M、Nagai Y、Shimada K、Sugii S、Ohshima M、Setoguchi K、Shimizu M
- Organizer
  ACR 2019 (American College of Rheumatology)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05914
[Presentation] 日本人ループス腎炎患者におけるヒドロキシクロロキンの適正使用に関する検討2019
- Author(s)
  清水美貴子、横川直人、杉井章二、瀬戸口京吾、大島美穂、古舘澄人、井沼道子、三浦裕也、橋口正行
- Organizer
  第40回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-19K05914
[Presentation] 日本人ループス腎炎患者におけるヒドロキシクロロキンの適正使用に関する検討2019
- Author(s)
  清水美貴子、横川直人、杉井章二、瀬戸口京吾、大島美穂、古舘澄人、井沼道子、三浦裕也、橋口正行
- Organizer
  第40回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-15K08045
[Presentation] Methotrexateの抗リウマチ効果に及ぼすポリグルタミン酸数の影響と効果発現機構の検討2018
- Author(s)
  浅野奨太、鈴木真伍、清水美貴子、橋口正行、田村悦臣
- Organizer
  第38回　日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-15K08045
[Presentation] ヒト滑膜細胞を用いたMethotrexate-polyglutamates体の抗リウマチ効果およびその制御機構の解明2016
- Author(s)
  鈴木真伍、清水美貴子、橋口正行、望月眞弓、田村悦臣
- Organizer
  第３７回　日本臨床薬理学会学術総会
- Place of Presentation
  米子コンベンションセンター（鳥取県・米子市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15K08045
[Presentation] プロバイオティクスのCYP3A4制御を介した脂質異常症治療の有用性の評価2016
- Author(s)
  班目陽一、清水美貴子、松本光晴、田村悦臣
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-15K08045
[Presentation] 関節リウマチに対するプロバイオティクスの有用性とメトトレキサートとの相互作用の検討2016
- Author(s)
  鈴木真伍、清水美貴子、松本光晴、袴田潤、橋口正行、望月眞弓、田村悦臣
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-15K08045
[Presentation] ヒト小腸でのビフィズズ菌によるBCRP発現制御機構の解明2015
- Author(s)
  清水美貴子、鈴木真伍、村尾直彦、松本光晴、橋口正行、望月眞弓、田村悦臣
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  京王プラザホテル(東京都・新宿区)
- Year and Date
  2015-12-11
- Data Source
  KAKENHI-PROJECT-15K08045
[Presentation] 関節リウマチ患者におけるメトトレキサートの治療反応性と遺伝子多型の関連のメタアナリシス2015
- Author(s)
  袴田潤、橋口正行、清水美貴子、丸山順也、望月眞弓
- Organizer
  第18回日本医薬品情報学会総会・学術大会
- Place of Presentation
  岡山大学創立五十周年記念館(岡山県・岡山市）
- Year and Date
  2015-06-27
- Data Source
  KAKENHI-PROJECT-15K08045
[Presentation] 乳酸菌によるCaco-2細胞のCYP3A4制御機構の解明2012
- Author(s)
  清水美貴子
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22590122
[Presentation] ヒト小腸モデルCaco-2細胞における乳酸菌のCYP3A4阻害機構2011
- Author(s)
  清水美貴子
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22590122
[Presentation] 小腸の抱合反応および薬物輸送担体機能に対する乳酸菌の影響2011
- Author(s)
  清水美貴子
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  浜松
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-22590122
[Presentation] Meta-analysis : Preventive effects of vitamin supplementation on the progression of cardiovascular disease2010
- Author(s)
  清水美貴子
- Organizer
  World Congress of Pharmacy and Pharmaceutical Sciences 2010, 70th Congress of FIP
- Place of Presentation
  ポルトガル、リスボン
- Data Source
  KAKENHI-PROJECT-22590122
[Presentation] メタアナリシスを用いた心血管疾患の予防・改善効果に対するビタミンの有用性評価2010
- Author(s)
  清水美貴子
- Organizer
  日本臨床薬理学会第31会年会
- Place of Presentation
  京都
- Year and Date
  2010-12-01
- Data Source
  KAKENHI-PROJECT-22590122
[Presentation] プロバイオティクスの科学的エビデンスの構築-基礎と臨床研究の統合-. (シンポジウム)2009
- Author(s)
  清水美貴子
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] Caco-2細胞のCYPIA/lB遺伝子発現および機能に及ぼすプロバイオティクスの影響.2009
- Author(s)
  田中佑京, 清水美貴子, 永田由樹, 田村悦臣
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] メタアナリシスを用いた血清脂質濃度に対するプロバイオティクス摂取の有用性の評価2009
- Author(s)
  内田怜、清水美貴子、望月眞弓、田村悦臣
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] ラットの薬物抱合反応に対するLactobacillus caseiの影響2009
- Author(s)
  増子由樹、清水美貴子、上田恵理華、田村悦臣
- Organizer
  第53回日本薬学会関東支部大会
- Place of Presentation
  埼玉
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] Caco-2細胞におけるCYP1A/1B誘導機構2009
- Author(s)
  清水美貴子、田中佑京、竹内修、永田由樹、田村悦臣
- Organizer
  フォーラム2009衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] ラットの薬物抱合反応に対する Lactobacillus casei の影響2009
- Author(s)
  増子由樹, 清水美貴子, 上田恵理華, 田村悦臣
- Organizer
  第53回日本薬学会関東支部大会
- Place of Presentation
  埼玉
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] メタアナリシスを用いた血清脂質濃度に対するプロバイオティクス摂取の有用性の評価.2009
- Author(s)
  内田怜, 清水美貴子, 望月眞弓, 田村悦臣
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] Caco-2細胞におけるに乳酸菌のCYP1A/1B誘導機構2009
- Author(s)
  清水美貴子, 田中佑京, 竹内修, 永田由樹, 田村悦臣
- Organizer
  フォーラム2009衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] プロバイオティクスの科学的エビデンスの構築-基礎と臨床研究の統合-(シンポジウム講演)2009
- Author(s)
  清水美貴子、杉田隆、竹内修、望月眞弓、田村悦臣
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] Caco-2細胞のCYP1A/1B遺伝子発現および機能に及ぼすプロバイオティクスの影響2009
- Author(s)
  田中佑京、清水美貴子、永田由樹、田村悦臣
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] Caco-2細胞の抱合反応に対するプロバイオティクスの影響2008
- Author(s)
  清水美貴子
- Organizer
  第128目年会日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] Meta-analysis : effects of probiotic supplementation on serumlipid levels in humans.2008
- Author(s)
  清水美貴子
- Organizer
  The 9th World Conference on Clinical Pharmacology and Therapeutics
- Place of Presentation
  カナダ、ケベック
- Year and Date
  2008-07-31
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] Meta-analysis: effects of probiotic supplementation on serum lipid levels in humans.2008
- Author(s)
  M. Shimizu, R. Uchida, M. Mochizuki, H. Tamura
- Organizer
  he 9th World Conference on Clinical Pharmacology and Therapeutics
- Place of Presentation
  Quebec City, Canada
- Year and Date
  2008-07-31
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] Caco-2細胞の抱合反応に対するプロバイオティクスの影響2008
- Author(s)
  清水美貴子、増子由樹、杉田隆、田村悦臣
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19590123
[Presentation] 間接比較法を用いたSt. John’s Wortの抗うつ効果の有用性の検討
- Author(s)
  清水美貴子、橋口正行、田村悦臣、望月眞弓
- Organizer
  第35回日本臨床薬理学会学術総会
- Place of Presentation
  ひめぎんホール(愛媛県松山市）
- Year and Date
  2014-12-04 – 2014-12-06
- Data Source
  KAKENHI-PROJECT-22590122
[Presentation] LC/MS/MSを用いたヒト生体試料中ピルシカイニドの定量法の確立
- Author(s)
  清水美貴子、橋口正行、志賀剛、中村紘一、田村悦臣、望月眞弓
- Organizer
  第34回日本臨床薬理学会学術総会
- Place of Presentation
  東京国際フォーラム(東京）
- Year and Date
  2013-12-04 – 2013-12-06
- Data Source
  KAKENHI-PROJECT-22590122
[Presentation] システマティックレビューによるイソフラボン摂取と乳がん発症リスクとの関連性の検討
- Author(s)
  清水美貴子、森重ちひろ、清水駿、橋口正行、田村悦臣
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸サンボーホール（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-22590122
[Presentation] 冠動脈疾患予防におけるプロバイオティクス摂取の医療経済分析.
- Author(s)
  清水美貴子
- Organizer
  第33回日本臨床薬理学会学術総会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-22590122
[Presentation] ビフィズス菌LKM512 は、ヒト小腸モデルCaco-2細胞でのコレステロール吸収を阻害する.
- Author(s)
  清水美貴子
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590122
[Presentation] メタ解析を用いた日本の大腸がん発症に対するコーヒー摂取の有用性評価
- Author(s)
  清水美貴子、吉田美咲、橋口正行、望月眞弓、田村悦臣
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館（熊本）
- Year and Date
  2014-03-27 – 2014-03-30
- Data Source
  KAKENHI-PROJECT-22590122

1. HASHIGUCHI Masayuki (10271355)

# of Collaborated Projects: 5 results

# of Collaborated Products: 39 results
2. SUGITA Takashi (10312076)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. TAKEUCHI Osamu (00249997)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 志賀剛 (00277211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 篠田啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 竹中健人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Mikiko 清水 美貴子

SHIMIZU Mikiko 清水 美貴子

Research Projects

Research Products

Co-Researchers

Development of a novel methotrexate administration method for rheumatoid arthritis patients using iontophoresis

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Microbiome therapy for rheumatic diseasesPrincipal Investigator

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Prevention and treatment of inflammatory diseases: control of pharmacokinetics with probioticsPrincipal Investigator

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Evaluation of the clinical usefulness of probiotics for the prevention and treatment of lifestyle-related diseasePrincipal Investigator

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Effects of probiotics on human intestinal absorption and metabolism of drugs.Principal Investigator

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[Journal Article] Pharmacokinetics of hydroxychloroquine in Japanese systemic lupus erythematosus patients with renal impairment2023

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[Journal Article] Comparison of Clinical Equivalence of Infliximab and its Biosimilar Combinations with Methotrexate in the Treatment of Rheumatoid Arthritis2022

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[Journal Article] Meta-Analysis Comparing Bivalirudin Versus. Unfractionated Heparin in Adult Patients With Extracorporeal Membrane Oxygenation2022

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[Journal Article] Meya-analysis comparing inappropriately low dose versus standard dose of direct oral anticoagulants in patients with atrial fibrillation2022

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[Journal Article] Early-Onset Hydroxychloroquine Retinopathy and a Possible Relationship to Blood Levels: Comment on the Article by Petri et al.2021

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[Journal Article] Ocular findings in Japanese patients with hydroxychloroquine retinopathy developing within 3 years of treatment.2021

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[Journal Article] Meta-analysis comparing direct oral anticoagulants versus vitamin K antagonists in patients with left ventricular thrombus2021

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[Journal Article] Meta-Analysis Comparing Direct Oral Anticoagulants Versus Warfarin in Morbidly Obese Patients With Atrial Fibrillation2020

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[Journal Article] Factors contributing to the systemic clearance of infliximab with long-term administration in Japanese patients with Crohn’s disease: Analysis using population pharmacokinetics2020

Shimizu Mikiko 清水美貴子

SHIMIZU Mikiko 清水美貴子