NAKATOGAWA Machiko 中戸川万智子

Researcher Number	90402461
Affiliation (based on the past Project Information) *help	2016: 東京工業大学, 生命理工学院, JSPS特別研究員 2015: 東京工業大学, フロンティア研究機構, 日本学術振興会特別研究員 2012 – 2014: 東京工業大学, フロンティア研究機構, 先進研究員
Review Section/Research Field	Principal Investigator Structural biochemistry
Keywords	Principal Investigator 結晶構造解析 / E2酵素 / オートファジー / E3酵素 / ユビキチン様タンパク質 / 蛍光顕微鏡 / 構造変化

Elucidation of the mechanism of lipidation of a ubiquitin-like protein that drives autophagosome formationPrincipal Investigator
- Principal Investigator
  
  Nakatogawa Machiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo Institute of Technology
Elucidation of the mode of action of Atg12-Atg5 conjugate in autophagyPrincipal Investigator
- Principal Investigator
  
  NAKATOGAWA Machiko
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo Institute of Technology

All 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Localization of Atg3 to autophagy-related membranes and its enhancement by the Atg8-family interacting motif to promote expansion of the membranes2015
- Author(s)
  Sakoh-Nakatogawa M, Kirisako H, Nakatogawa H*, Ohsumi Y*
- Journal Title
  
  FEBS Lett.
  
  Volume: 589 Issue: 6 Pages: 744-749
- DOI
  10.1016/j.febslet.2015.02.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23000015, KAKENHI-PLANNED-25111003, KAKENHI-PROJECT-26840017
[Journal Article] A novel role for 12/15-lipoxygenase in regulating autophagy.2015
- Author(s)
  Alwena H. Morgan, Victoria J. Hammond, Machiko Sakoh-Nakatogawa, Yoshinori Ohsumi, Christopher P. Thomas, Fabien Blanchet, Vincent Piguet, Kirill Kiselyov, Valerie B. O’Donnell
- Journal Title
  
  Redox Biology
  
  Volume: 4 Pages: 40-47
- DOI
  10.1016/j.redox.2014.11.005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26840017
[Journal Article] Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling2015
- Author(s)
  Sakakibara K, Eiyama A, Suzuki SW, Sakoh-Nakatogawa M, Okumura N, Tani M, Hashimoto A, Nagumo S, Kondo-Okamoto N, Kondo-Kakuta C, Asai E, Kirisako H, Nakatogawa H, Kuge O, Takao T, Ohsumi Y, Okamoto K
- Journal Title
  
  EMBO Journal
  
  Volume: 34 Issue: 21 Pages: 2703-2719
- DOI
  10.15252/embj.201591440
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440052, KAKENHI-PROJECT-26450127, KAKENHI-PROJECT-26840017, KAKENHI-PUBLICLY-15H01536, KAKENHI-PLANNED-25111003, KAKENHI-PUBLICLY-26111513, KAKENHI-PROJECT-15J06634, KAKENHI-PROJECT-13J40092, KAKENHI-PROJECT-25650067, KAKENHI-PROJECT-25291045, KAKENHI-PROJECT-25711005, KAKENHI-PROJECT-23000015
[Journal Article] Hrr25 triggers selective autophagy-related pathways by phosphorylating receptor proteins2014
- Author(s)
  Tanaka C, Tan LJ, Mochida K, Kirisako H, Koizumi M, Asai E, Sakoh-Nakatogawa M, Ohsumi Y, Nakatogawa H.
- Journal Title
  
  J. Cell Biol
  
  Volume: 207 Issue: 1 Pages: 91-105
- DOI
  10.1083/jcb.201402128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23000015, KAKENHI-PLANNED-25111003, KAKENHI-PROJECT-25711005, KAKENHI-PROJECT-26840017
[Journal Article] Atg12-Atg5 conjugate enhance E2 activity of Atg3 by rearranging its catalytic site2013
- Author(s)
  Sakoh-Nakatogawa M., Matoba K., Asai E., Kirisako H., Ishii J., Noda N. N., Inagaki F., Nakatogawa H., Ohsumi Y.
- Journal Title
  
  Nat. Struct. Mol. Biol.
  
  Volume: 20 Pages: 433-439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24770092
[Journal Article] Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site2013
- Author(s)
  Sakoh-Nakatogawa, M., Matoba, K., Asai, E., Kirisako, H., Ishii, J., Noda, N. N., Inagaki, F., Nakatogawa, H. and Ohsumi, Y
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: Vol.20 Issue: 4 Pages: 433-439
- DOI
  10.1038/nsmb.2527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23687012, KAKENHI-PROJECT-24770092, KAKENHI-PROJECT-25871076
[Journal Article] The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation2012
- Author(s)
  Nakatogawa H., Ohbayashi S., Sakoh-Nakatogawa M., Kakuta S., Suzuki S. W., Kirisako H., Kondo-Kakuta C., Noda N. N., Yamamoto H., Ohsumi Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Pages: 28503-28507
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24770092
[Presentation] オートファゴソーム形成を駆動するユビキチン様タンパク質脂質化反応のメカニズム2014
- Author(s)
  中戸川万智子、的場一晃、野田展生、稲垣冬彦、中戸川仁、大隅良典
- Organizer
  日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜／横浜産貿ホール（神奈川）
- Invited
- Data Source
  KAKENHI-PROJECT-24770092
[Presentation] Regulation of lipidation of the ubiquitin-like protein Atg8 that drives autophagosome formation2014
- Author(s)
  Machiko Sakoh-Nakatogawa, Kazuaki Matoba, Nobuo Noda, Fuyuhiko Inagaki, Hitoshi Nakatogawa, Yoshinori Ohsumi
- Organizer
  The 4th Asia Pacific Protein Association (APPA) Conference
- Place of Presentation
  済州島（韓国）
- Invited
- Data Source
  KAKENHI-PROJECT-24770092
[Presentation] A novel type of E3 enzyme : the autophagy-related ubiquitin-like protein conjugate Atg12-Atg5 induces a conformational change in the E2 enzyme Atg3 to enhance its conjugase activity2013
- Author(s)
  Sakoh-Nakatogawa M., Matoba K., Noda N. N., Nakatogawa H., Ohsumi Y.
- Organizer
  The 35^<th> Naito Conference
- Place of Presentation
  Sapporo, Japan
- Year and Date
  2013-07-11
- Data Source
  KAKENHI-PROJECT-24770092
[Presentation] A novel type of E3 enzyme: the autophagy-related ubiquitin-like protein conjugate Atg12-Atg5 induces a conformational change in the E2 enzyme Atg3 to enhance its conjugase activity2013
- Author(s)
  Machiko Sakoh-Nakatogawa, Kazuaki Matoba, Nobuo Noda, Hitoshi Nakatogawa, Yoshinori Ohsumi
- Organizer
  The 35th Naito Conference
- Place of Presentation
  シャトレーゼガトーキングダム（北海道）
- Data Source
  KAKENHI-PROJECT-24770092
[Presentation] The E3 enzyme Atg12-Atg5 rearranges the catalytic center of Atg3 to enhance its E2 activity2012
- Author(s)
  Sakoh-Nakatogawa M., Nakatogawa H., Ohsumi Y.
- Organizer
  The 6^<th> International Symposium on Autophagy 2012
- Place of Presentation
  Okinawa, Japan
- Data Source
  KAKENHI-PROJECT-24770092
[Presentation] オートファジーに必須のE3酵素Atg12-Atg5によるE2酵素Atg3の活性化機構2012
- Author(s)
  中戸川万智子、中戸川仁、大隅良典
- Organizer
  日本蛋白質科学会若手奨励賞シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2012-06-21
- Data Source
  KAKENHI-PROJECT-24770092
[Presentation] オートファジーに必須のE3酵素Atg12‐Atg5によるE2酵素Atg3の活性化機構2012
- Author(s)
  中戸川万智子・中戸川仁・大隅良典
- Organizer
  日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場（愛知県）
- Data Source
  KAKENHI-PROJECT-24770092
[Presentation] The E3 enzyme Atg12-Atg5 rearranges the catalytic center of Atg3 to enhace its E2 activity2012
- Author(s)
  Machiko Sakoh-Nakatogawa, Hitoshi Nakatogawa, Yoshinori Ohsumi
- Organizer
  The 6th international symposium on autophagy 2012
- Place of Presentation
  万国津梁館（沖縄県）
- Data Source
  KAKENHI-PROJECT-24770092
[Presentation] オートファジーに関わる２つのユビキチン様タンパク質結合系のクロストーク2012
- Author(s)
  中戸川万智子
- Organizer
  第３５回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場（福岡県）
- Invited
- Data Source
  KAKENHI-PROJECT-24770092
[Presentation] オートファジーに関わる2つのユビキチン様タンパク質結合系のクロストーク2012
- Author(s)
  中戸川万智子、中戸川仁、大隅良典
- Organizer
  日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-24770092
[Presentation] オートファゴソーム形成を駆動するユビキチン様タンパク質脂質化反応のメカニズム
- Author(s)
  中戸川万智子、的場一晃、野田展生、稲垣冬彦、中戸川仁、大隅良典
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜/横浜産貿ホール　マリネリア（横浜）
- Year and Date
  2014-06-25 – 2014-06-27
- Invited
- Data Source
  KAKENHI-PROJECT-26840017
[Presentation] Regulation of lipidation of the ubiquitin-like protein Atg8 that drives autophagosome formation
- Author(s)
  Machiko Sakoh-Nakatogawa, Kazuaki Matoba, Nobuo Noda, Fuyuhiko Inagaki, Hitoshi Nakatogawa, Yoshinori Ohsumi
- Organizer
  The 4th Asia Pacific Protein Association Conference 2014
- Place of Presentation
  The 4th Asia Pacific Protein Association Conference 2014 (Jeju, Korea)
- Year and Date
  2014-05-17 – 2014-05-20
- Invited
- Data Source
  KAKENHI-PROJECT-26840017

1. OKAMOTO Noriko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. NODA Nobuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 大隅良典

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 岡本浩二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKATOGAWA Machiko 中戸川 万智子

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of lipidation of a ubiquitin-like protein that drives autophagosome formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mode of action of Atg12-Atg5 conjugate in autophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Localization of Atg3 to autophagy-related membranes and its enhancement by the Atg8-family interacting motif to promote expansion of the membranes2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel role for 12/15-lipoxygenase in regulating autophagy.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hrr25 triggers selective autophagy-related pathways by phosphorylating receptor proteins2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Atg12-Atg5 conjugate enhance E2 activity of Atg3 by rearranging its catalytic site2013

Author(s)

Journal Title

Data Source

[Journal Article] Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation2012

Author(s)

Journal Title

Data Source

[Presentation] オートファゴソーム形成を駆動するユビキチン様タンパク質脂質化反応のメカニズム2014

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Regulation of lipidation of the ubiquitin-like protein Atg8 that drives autophagosome formation2014

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] A novel type of E3 enzyme : the autophagy-related ubiquitin-like protein conjugate Atg12-Atg5 induces a conformational change in the E2 enzyme Atg3 to enhance its conjugase activity2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] A novel type of E3 enzyme: the autophagy-related ubiquitin-like protein conjugate Atg12-Atg5 induces a conformational change in the E2 enzyme Atg3 to enhance its conjugase activity2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] The E3 enzyme Atg12-Atg5 rearranges the catalytic center of Atg3 to enhance its E2 activity2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] オートファジーに必須のE3酵素Atg12-Atg5によるE2酵素Atg3の活性化機構2012

Author(s)

Organizer

Place of Presentation

Year and Date

NAKATOGAWA Machiko 中戸川万智子