KOTANI Yoshikazu 小谷義一

Researcher Number	90403287
Other IDs
Affiliation (based on the past Project Information) *help	2011 – 2015: 神戸大学, 医学(系)研究科(研究院), 講師 2013: 神戸大学, 大学院医学研究科, 講師 2011: 神戸大学, 大学院・医学研究科, 講師 2009 – 2011: Kobe University, 医学研究科, 講師 2008: 神戸大学, 大学院・医学研究科, 講師 … More 2007: 神戸大学, 医学部附属医院, 助教 2007: Kobe University, Hospital, Assistant Professor 2006: 神戸大学, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine / Radiation science / Circulatory organs internal medicine
Keywords	Principal Investigator Bronchial asthma / ADCT / 慢性閉塞性肺疾患 / モストグラフ / COPD / Area-detector CT / 呼吸機能検査 / 閉塞性肺疾患 / 領域検出型CT Except Principal Investigator スフィンゴシン1リン酸 … More / 放射線 / 気管支喘息 / スフィンゴシン / bronchial asthma / lung fibroblast / sphingosine kinase / sphingosine 1-phosphate / 急性喘息モデル / 線維芽細胞 / スフィンゴシンキナーゼ / 国際情報交換 / アンフィレグリン / 薬剤耐性 / アムルビシン / 定量的画像解析 / Lung cancer / Quantitative Imaging / Perfusion CT / 肺癌 / 低線量 / 灌流CT / Lung Cancer / Low-Dose / Ｐｅｒｆｕｓｉｏｎ　CT / 生体機能利用 / マウス / 喘息 / 抗原提示細胞 / スフィンゴシン１リン酸 / 樹状細胞 / 放射線、X線、粒子線 / 呼吸器 / 粒子線 / X線 / 生命科学 / goblet cells / IL-13 / ERK / mucin / S1P受容体 / Shingosine kinase / SlP受容体 / Sphingosine kinase / 粘液産生 / 接着分子 / 循環器 / 末梢血管 / 血管新生 / 血管内皮 / (5) 接着分子 / (4) 循環器 / (3)末梢血管 / (2) 血管新生 / (1) 血管内皮 Less

Analysis of resistance mechanism to amrubicin
- Principal Investigator
  
  Tachihara Motoko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kobe University
Prediction of Therapeutic Effect by Quantitative Perfusion CT with Omics Information
- Principal Investigator
  
  OHNO YOSHIHARU
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Kobe University
The new strategy of asthma treatment by controlled the sphingosine signals.
- Principal Investigator
  
  KOBAYASH KAZUYUKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kobe University
The control of airway mucus secretion via sphingosine signals
- Principal Investigator
  
  NISHIMURA Yoshihiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kobe University
The evaluation of effect of anti-inflammatory drugs on chronic obstructive pulmonary disease with area-detector CTPrincipal Investigator
- Principal Investigator
  
  KOTANI Yoshikazu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kobe University
New morphological and functional diagnosis of COPD and Asthma on 320-detector-row CT
- Principal Investigator
  
  TAKENAKA Daisuke
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Kobe University
Establishement of a novel anti-tumor therapy utilizing inhibition of angiogenesis
- Principal Investigator
  
  ISHIDA Tatsuro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kobe University
Research of sphingosine kinase modification in acute lung injury
- Principal Investigator
  
  NISHIMURA Yoshihiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kobe University

All 2012 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Sphingosine kinase 1 regulates mucin production via ERK phosphorylation2010
- Author(s)
  Kono Y, Nishiuma T, Okada T, Kobayashi K, Funada Y, Kotani Y, Jahangeer S, Nakamura S, Nishimura Y
- Journal Title
  
  Pulm Pharmacol Ther
  
  Volume: 23(1) Pages: 36-42
- NAID
  120003290046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590965
[Journal Article] Targeted inactivation of endothelial lipase attenuates lung allergic inflammation through raising plasma HDL level and inhibiting eosinophil infiltration2009
- Author(s)
  Otera H, Ishida T, Nishiuma T, Kobayashi K, Kotani K, Yasuda T, Kundu RK, Quertermous T, Hirata K, Nishimura Y
- Journal Title
  
  American Journal of Physiology-Lung Cellular and Molecular Physiology 296(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590862
[Journal Article] Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model2008
- Author(s)
  Nishiuma, T, Nishimura, Y, Okada, T, Kuramoto, E, Kotani, Y, Jahangeer, S, Nakamura, S
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590848
[Journal Article] Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model.2008
- Author(s)
  Nishiuma T, Nishimura Y, Okada T, Kuramoto E, Kotani Y, Jahangeer S, Nakamura S
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590848
[Journal Article] Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta12007
- Author(s)
  Kono, Y, Nishiuma, T, Nishimura, Y, Kotani, Y, Okada, T, Nakamura, S, Yokoyama, M
- Journal Title
  
  Am J Respir Cell Mol Biol 37
  
  Pages: 395-404
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590848
[Journal Article] Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta12007
- Author(s)
  Kono Y, Nishiuma T, Nishimura Y, Kotani Y, Okada T, Nakamura S, Yokoyama M.
- Journal Title
  
  Am J Respir Cell Mol Biol 37
  
  Pages: 395-404
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590848
[Presentation] 喘息モデルマウスにおけるDMS とFTY-720の作用に対する検討2012
- Author(s)
  日河良崇、小林和幸、石川結美子、船田泰弘、小谷義一、西村善博
- Organizer
  第52回日本呼吸器学会学術講演会
- Place of Presentation
  神戸コンベンションセンター
- Year and Date
  2012-04-20
- Data Source
  KAKENHI-PROJECT-23591119
[Presentation] 喘息モデルマウスにおけるDMSとFTY-720の作用に対する検討2012
- Author(s)
  河良崇, 小林和幸, 石川結美子, 船田泰弘, 小谷義一, 西村善博
- Organizer
  第52回　日本呼吸科学会学術講演会
- Place of Presentation
  神戸コンベンションセンター
- Data Source
  KAKENHI-PROJECT-23591119
[Presentation] COPD患者における呼吸インピーダンスの意義2012
- Author(s)
  新家治子, 小林和幸, 河良崇櫨, 木暢子, 山本正嗣, 大野良治, 小谷義一, 西村善博
- Organizer
  第4回呼吸イメージング研究会
- Place of Presentation
  ピアザ淡海滋賀
- Year and Date
  2012-02-11
- Data Source
  KAKENHI-PROJECT-21590966
[Presentation] Comparison of 3-D-visualized respiratory impedance patterns and structural change detected by CT in smokers2011
- Author(s)
  Shinke H, Kotani Y, et al.
- Organizer
  Joint Meeting combining The 3rd meeting of the Japanese Society of Pulmonary Functional Imaging and 5th International Workshop for Pulmonary Functional Imaging
- Place of Presentation
  淡路夢舞台国際会議場(兵庫県)
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-21590966
[Presentation] Difference between respiratory impedance pattern and structural change in analysis of smoking-induced expiratory flow limitation2011
- Author(s)
  H. N. Shinke, M. Yamamoto, N. Hazeki, Y. Kawa, K. Kobayashi, Y. Funada, Y. Kotani, Y. Ohno, Y. Nishimura
- Organizer
  ATS international conference 2011
- Place of Presentation
  デンバーUSA
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-21590966
[Presentation] DMSとFTY-720は喘息モデルマウスにおいて気道炎症を抑制する2011
- Author(s)
  河　良崇、小林和幸、石川結美子、船田泰弘、小谷義一、西村善博
- Organizer
  第61回日本アレルギー学会秋季学術大会
- Place of Presentation
  グランドプリンスホテル新高輪国際館パミール
- Data Source
  KAKENHI-PROJECT-23591119
[Presentation] DMSとFTY-720は喘息モデルマウスにおいて気道炎症を抑制する2011
- Author(s)
  河良崇、小林和幸、石川結美子、山本正嗣、船田泰弘、小谷義一、西村善博
- Organizer
  第61回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-21590965
[Presentation] Comparison of3-D-visualized respiratory impedance patterns and structural change detected by CT in smokers2011
- Author(s)
  Haruko Shinke, Masatsugu Yamamoto, Nobuko Hazeki, Kazuyuki Kobayashi, Yasuhiro Funada, Yoshikazu Kotani, Daisuke Takenaka, Yoshiharu Ohno, Yoshihiro Nishimura
- Organizer
  Joint Meeting combining The3rd meeting of the Japanese Society of Pulmonary Functional Imaging and 5th International Workshop for Pulmonary Functional Imaging
- Place of Presentation
  淡路夢舞台国際会議場,兵庫
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-21590966
[Presentation] DMS とFTY720 は喘息モデルマウスにおいて気道炎症を抑制する2011
- Author(s)
  日河良崇、小林和幸、石川結美子、船田泰弘、小谷義一、西村善博
- Organizer
  第61回日本アレルギー学会秋季学術大会
- Place of Presentation
  グランドプリンスホテル新高輪国際館
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-23591119
[Presentation] 末梢気道抵抗のモストグラフによる画像化と喫煙者における小気道病変の早期診断への応用2010
- Author(s)
  山本正嗣, 小谷義一, 他
- Organizer
  呼吸機能イメージング研究会学術集会
- Place of Presentation
  沖縄コンベンションセンター(沖縄県)
- Year and Date
  2010-01-30
- Data Source
  KAKENHI-PROJECT-21590966
[Presentation] Visualization of variance of respiratory impedance in smokers and COPD2010
- Author(s)
  Yamamoto M, Kotani Y, et al
- Organizer
  ERS2010
- Place of Presentation
  バルセロナスペイン
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21590966
[Presentation] Visualization of variance of respiratory impedance in smokers and COPD2010
- Author(s)
  Yamamoto M, Kotani Y, et al.
- Organizer
  ERS 2010
- Place of Presentation
  バルセロナ(スペイン)
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21590966
[Presentation] Inhaled treatment of sphingosine kinase inhibition attenuates airway inflammation in ovalbumin(OVA)challenge mice model2007
- Author(s)
  Nishiuma, T, Nishimura, Y, Kobayashi, K, Kotani, Y, Yokoyama, M
- Organizer
  American Thoracic Society
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2007-05-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590848
[Presentation] Sphingosine Kinase(SPHK)1 Regulates Differentiation of Lung Fibroblasts Mediated by Transforming Growth Factor (TGF) beta12007
- Author(s)
  Kono Y, Nishiuma T, Nishimura Y, Okada T, Kobayashi K, Funada Y, Kotani Y, Nakamura S, Yokoyama M
- Organizer
  米国胸部疾患学会(American Thoracic Society)
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2007-05-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590848
[Presentation] Effect of Sphingosine Kinase on IL-13 Induced Goblet cell Metaplasia2007
- Author(s)
  Kono Y, Nishiuma T, Kuramoto E, Yamamoto M, Sakashita A, Kobayashi K, Funada Y, Kotani Y, Nishimura Y
- Organizer
  アジア太平洋呼吸器学会(Asian Pacific Society of Respirology)
- Place of Presentation
  Gold Coast, Australia
- Year and Date
  2007-12-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590848
[Presentation] Sphingosine Kinase(SPHK)1 Regulates Differentiation of Lung Fibroblasts Mediated by Transforming Growth Factor(TGF)betal2007
- Author(s)
  Kono, Y, Nishiuma, T, Nishimura, Y, Okada, T, Kobayashi, K, Funada, Y, Kotani, Y, Nakamura, S, Yokoyama, M
- Organizer
  American Thoracic Society
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2007-05-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590848
[Presentation] Inhaled treatment of sphingosine kinase inhibition attenuates airway inflammation in ovalbumin(OVA)challenged mice model2007
- Author(s)
  Nishiuma T, Nishimura Y, Kobayashi K, Kotani Y, Yokoyama M
- Organizer
  米国胸部疾患学会(American Thoracic Society)
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2007-05-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590848
[Presentation] Effect of sphingosine kinase on IL-13 induced goblet cell metaplasia2007
- Author(s)
  Kono, Y, Nishiuma, T, Nishimura, Y, Okada, T, Kobayashi, K, Funada, Y, Kotani, Y, Nakamura, S, Yokoyama, M
- Organizer
  Asian Pacific Society of Respirology
- Place of Presentation
  Gold Coast, Australia
- Year and Date
  2007-12-04
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590848

1. NISHIMURA Yoshihiro (20291453)

# of Collaborated Projects: 7 results

# of Collaborated Products: 19 results
2. KOBAYASHI Kazuyuki (50403275)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
3. TAKENAKA Daisuke (60258233)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. FUNADA Yasuhiro (60437465)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
5. OHNO Yoshiharu (30324924)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
6. HIRATA Kenichi (20283880)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. OKADA Taro (80304088)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
8. NISHIUMA Teruaki (10379414)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
9. SUGIMURA Kazuro (00136384)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. MATSUMOTO Sumiaki (60397833)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. YOSHIKAWA Takeshi (40332788)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. ISHIDA Tatsuro (00379413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. ITO Tomoo (20301880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KOYAMA Hisanobu (30546487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Tachihara Motoko (40448626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAMURA DAISUKE (80646597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NAGANO TATSUYA (80624684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 眞庭謙昌 (50362778)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 西村英輝 (80444610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOTANI Yoshikazu 小谷 義一

Research Projects

Research Products

Co-Researchers

Analysis of resistance mechanism to amrubicin

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prediction of Therapeutic Effect by Quantitative Perfusion CT with Omics Information

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The new strategy of asthma treatment by controlled the sphingosine signals.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The control of airway mucus secretion via sphingosine signals

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The evaluation of effect of anti-inflammatory drugs on chronic obstructive pulmonary disease with area-detector CTPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New morphological and functional diagnosis of COPD and Asthma on 320-detector-row CT

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishement of a novel anti-tumor therapy utilizing inhibition of angiogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research of sphingosine kinase modification in acute lung injury

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sphingosine kinase 1 regulates mucin production via ERK phosphorylation2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Targeted inactivation of endothelial lipase attenuates lung allergic inflammation through raising plasma HDL level and inhibiting eosinophil infiltration2009

Author(s)

Journal Title

Data Source

[Journal Article] Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model.2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta12007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta12007

Author(s)

Journal Title

Description

KOTANI Yoshikazu 小谷義一