Nagai Noriaki 長井紀章

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NAGAI Noriaki 長井紀章

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Researcher Number	90411579
Other IDs
Affiliation (Current)	2025: 近畿大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 近畿大学, 薬学部, 教授 2017 – 2022: 近畿大学, 薬学部, 准教授 2013 – 2016: 近畿大学, 薬学部, 講師 2011 – 2012: 近畿大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy / Hygiene Except Principal Investigator Basic Section 56060:Ophthalmology-related / Medical pharmacy
Keywords	Principal Investigator 湿式破砕 / ビーズミル / バイオアベイラビリティ / ナノ結晶製剤 / 網膜 / 糖尿病 / 点眼製剤 / チロキサポール / ビーズミル破砕 / 薬物療法 … More / 難溶性薬物 / 眼内バイオアベイラビリティ / 薬物送達システム / in situゲル / ドラッグデリバリーシステム / ナノ結晶 / 界面活性剤 / 関節リウマチ / 消化管傷害 / NSAIDs / 口腔内崩壊錠 / DDA / DDS / 眼圧 / 角膜透過 / 緑内障 / 眼後部治療 / シロスタゾール / ナノ粒子 / 脂質過酸化 / Ca2+-ATPase / Ca(2+)-ATPase / シトクロムcオキシダーゼ / ヒト水晶体上皮細胞 / ミトコンドリアDNA / Ca^<2+>-ATPase / ATP / 酸化的ストレス / 一酸化窒素 / 白内障 / シトクロム cオキシダーゼ / 水晶体上皮細胞 / DNA / ミトコンドリア … More Except Principal Investigator 糖尿病網膜症 / 再生医療 / 薬物評価 / iPS細胞 / ハイブリッド培養 / 網膜再生 / 網膜グリア機能 / 神経血管連関 / ドラッグデリバリー / ナノ粒子点眼 / 網膜神経血管連関 / 網膜血流 / ナノ粒子化点眼 / 虚血再灌流障害 / 薬物送達 / 三次元網膜再生 / 薬物安全性評価 / 電気生理 / 網膜神経細胞 / 虹彩由来iPS細胞 / 家兎 / 薬物安定性 / マイバム / アクリル酸ポリマー / レボフロキサシン / マイボーム腺 / 界面活性剤 / ナノ粒子 / 抗菌薬 / 貼付型眼瞼透過型製剤 / シュレム管 / アセチルコチン / 角膜傷害 / 点眼薬 / 網膜 / 眼瞼適用ゲルパッチ / 一酸化窒素 / 視神経 / 眼圧 / シクロデキストリン / 緑内障 / ピログルタミン酸 Less

薬物ナノ粒子化技術を基盤としたコンタクト型デバイスの開発と網膜症治療への応用Principal Investigator
- Principal Investigator
  
  長井紀章
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kindai University
Overcoming Diabetic Retinopathy through Local Control of Oxidative Stress
- Principal Investigator
  
  櫛山暁史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Meiji Pharmaceutical University
Regeneration of Retina with Physiological Functions by Hybrid Culture and Evaluation of Drugs / Production of Novel iPS Cells for Transplantation.
- Principal Investigator
  
  山本直樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Fujita Health University
Novel Treatment of Nano-eyedrop for Diabetic retinopathy
- Principal Investigator
  
  長岡泰司
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Asahikawa Medical College
  Nihon University
Design of ophthalmic in situ gel incorporating solid nanoparticles for therapy of retinal diseasePrincipal Investigator
- Principal Investigator
  
  Nagai Noriaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kindai University
Development of three-dimensional retinal regeneration with electrophysiological function and drug safety evaluation using the human iris derived iPS cells
- Principal Investigator
  
  Yamamoto Naoki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Fujita Health University
  Kanazawa Medical University
Design of new ophthalmic formulations based on drug nanoparticles and it's application for therapy of retinopathyPrincipal Investigator
- Principal Investigator
  
  Nagai Noriaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kindai University
Design of novel nanomedicine containing NSAIDs for improvement of drug-induced gastrointestinal lesionsPrincipal Investigator
- Principal Investigator
  
  NAGAI Noriaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kindai University
Design of transdermal ophthalmic therapy using drug nanoparticle technology and application of it as eye infection treatment
- Principal Investigator
  
  ITO Yoshimasa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kindai University
Ophthalmic formulation of solid nanoparticles permits the retinal therapy, and lead to the therapy in the glaucoma patientPrincipal Investigator
- Principal Investigator
  
  NAGAI Noriaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kinki University
Development of the effective ophthalmic formulations that simultaneously targeting intraocular pressure and optic nerve
- Principal Investigator
  
  ITO Yoshimasa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kinki University
Early prediction of senile cataract based on the elucidation of mitochondrial DNAPrincipal Investigator
- Principal Investigator
  
  NAGAI Noriaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hygiene
- Research Institution
  Kinki University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Therapeutic Effects of Hydrogel Formulations Incorporating Troxipide Nanoparticles on Oral Mucositis in Hamsters.2023
- Author(s)
  Kadowaki R, Ogata F, Nishida M, Komatsu M, Otake H, Nakazawa Y, Yamamoto N, Kawasaki N, Nagai N.
- Journal Title
  
  Drug Des Devel Ther.
  
  Volume: 17 Pages: 3349-3361
- DOI
  10.2147/dddt.s433776
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K09017, KAKENHI-PROJECT-21K06656
[Journal Article] Skin absorption of felbinac solid nanoparticles in gel formulation containing l-menthol and carboxypolymethylene2023
- Author(s)
  Kadowaki Reita、Ogata Fumihiko、Fushiki Aoi、Daimyo Saki、Deguchi Saori、Otake Hiroko、Nagata Mayumi、Sasaki Hiroshi、Kawasaki Naohito、Nagai Noriaki
- Journal Title
  
  Journal of Pharmaceutical Health Care and Sciences
  
  Volume: 9 Issue: 1 Pages: 20-20
- DOI
  10.1186/s40780-023-00290-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06656
[Journal Article] Hesperetin treatment attenuates glycation of lens proteins and advanced?glycation end products generation2023
- Author(s)
  Doki Yuri、Nakazawa Yosuke、Morishita Naoki、Endo Shin、Nagai Noriaki、Yamamoto Naoki、Tamura Hiroomi、Funakoshi?Tago Megumi
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: 27 Issue: 5 Pages: 12990-12990
- DOI
  10.3892/mmr.2023.12990
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07184, KAKENHI-PROJECT-23K09017
[Journal Article] Aquaporins contribute to vacuoles formation in Nile grass type II diabetic rats2023
- Author(s)
  Aihara Kana、Nakazawa Yosuke、Takeda Shun、Hatsusaka Natsuko、Onouchi Takanori、Hiramatsu Noriko、Nagata Mayumi、Nagai Noriaki、Funakoshi-Tago Megumi、Yamamoto Naoki、Sasaki Hiroshi
- Journal Title
  
  Medical Molecular Morphology
  
  Volume: 56 Issue: 4 Pages: 274-287
- DOI
  10.1007/s00795-023-00365-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06263, KAKENHI-PROJECT-23K09017
[Journal Article] Orally disintegrating tablets containing famotidine nanoparticles provide high intestinal absorbability via the energy-dependent endocytosis pathway2023
- Author(s)
  Nagai Noriaki、Ogata Fumihiko、Kadowaki Reita、Deguchi Saori、Otake Hiroko、Nakazawa Yosuke、Nagata Mayumi、Sasaki Hiroshi、Kawasaki Naohito
- Journal Title
  
  Frontiers in Bioengineering and Biotechnology
  
  Volume: 11 Pages: 1167291-1167291
- DOI
  10.3389/fbioe.2023.1167291
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06656
[Journal Article] Piezo1 channel causes lens sclerosis via transglutaminase 2 activation2023
- Author(s)
  Doki Yuri、Nakazawa Yosuke、Sukegawa Miyu、Petrova Rosica S.、Ishida Yuki、Endo Shin、Nagai Noriaki、Yamamoto Naoki、Funakoshi-Tago Megumi、Donaldson Paul J.
- Journal Title
  
  Experimental Eye Research
  
  Volume: 237 Pages: 109719-109719
- DOI
  10.1016/j.exer.2023.109719
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06263, KAKENHI-PROJECT-23K09017
[Journal Article] Recovery from indomethacin-induced gastrointestinal bleeding by treatment with teprenone.2023
- Author(s)
  Deguchi S, Iwakami A, Tujigiwa M, Otake H, Mano Y, Yamamoto N, Nakazawa Y, Misra M, Nagai N.
- Journal Title
  
  J Pharm Health Care Sci.
  
  Volume: 9 Issue: 1 Pages: 44-44
- DOI
  10.1186/s40780-023-00312-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K09017
[Journal Article] Formation of three-dimensional cell aggregates expressing lens-specific proteins in various cultures of human iris-derived tissue cells and iPS cells2022
- Author(s)
  Hiramatsu Noriko、Yamamoto Naoki、Kato Yu、Nagai Noriaki、Isogai Sumito、Imaizumi Kazuyoshi
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 24 Issue: 2 Pages: 539-539
- DOI
  10.3892/etm.2022.11476
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08245, KAKENHI-PROJECT-19K18369, KAKENHI-PROJECT-20K09815
[Journal Article] Iris-derived induced pluripotent stem cells that express GFP in all somatic cells of mice and differentiate into functional retinal neurons2022
- Author(s)
  Hiramatsu Noriko、Yamamoto Naoki、Ohkuma Mahito、Nagai Noriaki、Miyachi Ei-ichi、Yamatsuta Kumiko、Imaizumi Kazuyoshi
- Journal Title
  
  Medical Molecular Morphology
  
  Volume: 55 Issue: 4 Pages: 292-303
- DOI
  10.1007/s00795-022-00330-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09838, KAKENHI-PROJECT-22K08245, KAKENHI-PROJECT-20K09815
[Journal Article] Minoxidil Nanoparticles Targeting Hair Follicles Enhance Hair Growth in C57BL/6 Mice2022
- Author(s)
  Oaku Yoshihiro、Abe Akinari、Sasano Yohei、Sasaki Fuka、Kubota Chika、Yamamoto Naoki、Nagahama Tohru、Nagai Noriaki
- Journal Title
  
  Pharmaceutics
  
  Volume: 14 Issue: 5 Pages: 947-947
- DOI
  10.3390/pharmaceutics14050947
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09815
[Journal Article] Oral Formulation Based on Irbesartan Nanocrystals Improve Drug Solubility, Absorbability, and Efficacy2022
- Author(s)
  Nagai Noriaki、Ogata Fumihiko、Ike Ayari、Shimomae Yurisa、Osako Hanano、Nakazawa Yosuke、Yamamoto Naoki、Kawasaki Naohito
- Journal Title
  
  Pharmaceutics
  
  Volume: 14 Issue: 2 Pages: 387-387
- DOI
  10.3390/pharmaceutics14020387
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07184, KAKENHI-PROJECT-20K09815, KAKENHI-PROJECT-21K06656
[Journal Article] Function of mitochondrial cytochrome c oxidase is enhanced in human lens epithelial cells at high temperatures2022
- Author(s)
  Takeda Shun、Yamamoto Naoki、Nagai Noriaki、Hiramatsu Noriko、Deguchi Saori、Hatsusaka Natsuko、Kubo Eri、Sasaki Hiroshi
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: 27 Issue: 1 Pages: 19-19
- DOI
  10.3892/mmr.2022.12906
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08245, KAKENHI-PROJECT-20K09815, KAKENHI-PROJECT-23K09017
[Journal Article] Combination of Lanosterol and Nilvadipine Nanosuspensions Rescues Lens Opacification in Selenite-Induced Cataractic Rats2022
- Author(s)
  Deguchi Saori、Kadowaki Reita、Otake Hiroko、Taga Atsushi、Nakazawa Yosuke、Misra Manju、Yamamoto Naoki、Sasaki Hiroshi、Nagai Noriaki
- Journal Title
  
  Pharmaceutics
  
  Volume: 14 Issue: 7 Pages: 1520-1520
- DOI
  10.3390/pharmaceutics14071520
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06656, KAKENHI-PROJECT-20K09815
[Journal Article] Transdermal System Based on Solid Cilostazol Nanoparticles Attenuates Ischemia/Reperfusion-Induced Brain Injury in Mice2021
- Author(s)
  Otake Hiroko、Yamaguchi Mizuki、Ogata Fumihiko、Deguchi Saori、Yamamoto Naoki、Sasaki Hiroshi、Kawasaki Naohito、Nagai Noriaki
- Journal Title
  
  Nanomaterials
  
  Volume: 11 Issue: 4 Pages: 1009-1009
- DOI
  10.3390/nano11041009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09815
[Journal Article] Nanocrystalline Suspensions of Irbesartan Enhance Oral Bioavailability by Improving Drug Solubility and Leading Endocytosis Uptake into the Intestine2021
- Author(s)
  Deguchi Saori、Ogata Fumihiko、Watanabe Masaki、Otake Hiroko、Yamamoto Naoki、Kawasaki Naohito、Nagai Noriaki
- Journal Title
  
  Pharmaceutics
  
  Volume: 13 Issue: 9 Pages: 1404-1404
- DOI
  10.3390/pharmaceutics13091404
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09815, KAKENHI-PROJECT-21K06656
[Journal Article] 【外国誌要覧】新規不死化ヒト水晶体上皮細胞を用いた低温培養における水晶体蛋白質の影響2021
- Author(s)
  山本直樹, 武田峻, 初坂奈津子, 平松範子, 長井紀章, 出口粧央里, 中澤洋介, 高田匠, 小寺紗千子, 平田晃正, 久保江理, 佐々木洋
- Journal Title
  
  日本眼科学会誌
  
  Volume: 125 Pages: 474-474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09815
[Journal Article] Novel Technique for Retinal Nerve Cell Regeneration with Electrophysiological Functions Using Human Iris-Derived iPS Cells.2021
- Author(s)
  Yamamoto N, Hiramatsu N, Ohkuma M, Hatsusaka N, Takeda S, Nagai N, Miyachi EI, Kondo M, Imaizumi K, Horiguchi M, Kubo E, Sasaki H.
- Journal Title
  
  Cells.
  
  Volume: 10 (4) Issue: 4 Pages: 743-743
- DOI
  10.3390/cells10040743
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09815, KAKENHI-PROJECT-20K09838, KAKENHI-PROJECT-18K15935
[Journal Article] Morphological comparison between three-dimensional structure of immortalized human lens epithelial cells and Soemmering's ring.2021
- Author(s)
  Hiramatsu N, Nagai N, Kondo M, Imaizumi K, Sasaki H, Yamamoto N.
- Journal Title
  
  Med Mol Morphol.
  
  Volume: Online ahead of print. Issue: 3 Pages: 216-226
- DOI
  10.1007/s00795-021-00280-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09815, KAKENHI-PROJECT-18K15935
[Journal Article] Instillation of Ophthalmic Formulation Containing Nilvadipine Nanocrystals Attenuates Lens Opacification in Shumiya Cataract Rats2021
- Author(s)
  Goto Ryoka、Yamada Shigehiro、Otake Hiroko、Nakazawa Yosuke、Oka Mikako、Yamamoto Naoki、Sasaki Hiroshi、Nagai Noriaki
- Journal Title
  
  Pharmaceutics
  
  Volume: 13 Issue: 12 Pages: 1999-1999
- DOI
  10.3390/pharmaceutics13121999
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09815, KAKENHI-PROJECT-21K06656
[Journal Article] Balance of Drug Residence and Diffusion in Lacrimal Fluid Determine Ocular Bioavailability in In Situ Gels Incorporating Tranilast Nanoparticles2021
- Author(s)
  Minami Misa、Otake Hiroko、Nakazawa Yosuke、Okamoto Norio、Yamamoto Naoki、Sasaki Hiroshi、Nagai Noriaki
- Journal Title
  
  Pharmaceutics
  
  Volume: 13 Issue: 9 Pages: 1425-1425
- DOI
  10.3390/pharmaceutics13091425
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09815, KAKENHI-PROJECT-21K06656
[Journal Article] Capsaicin attenuates TGFβ2-induced epithelial-mesenchymal-transition in lens epithelial cells in vivo and in vitro2021
- Author(s)
  Sugiyama Yuki、Nakazawa Yosuke、Sakagami Toko、Kawata Sara、Nagai Noriaki、Yamamoto Naoki、Funakoshi-Tago Megumi、Tamura Hiroomi
- Journal Title
  
  Experimental Eye Research
  
  Volume: 213 Pages: 108840-108840
- DOI
  10.1016/j.exer.2021.108840
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07184, KAKENHI-PROJECT-20K09815
[Journal Article] Energy-Dependent Endocytosis Is Responsible for Skin Penetration of Formulations Based on a Combination of Indomethacin Nanoparticles and L-Menthol in Rat and G?ttingen Minipig2021
- Author(s)
  Otake Hiroko、Yamaguchi Mizuki、Ogata Fumihiko、Deguchi Saori、Yamamoto Naoki、Sasaki Hiroshi、Kawasaki Naohito、Nagai Noriaki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 10 Pages: 5137-5137
- DOI
  10.3390/ijms22105137
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09815
[Journal Article] An in situ Gelling System Based on Methylcellulose and Tranilast Solid Nanoparticles Enhances Ocular Residence Time and Drug Absorption Into the Cornea and Conjunctiva2020
- Author(s)
  Nagai Noriaki、Minami Misa、Deguchi Saori、Otake Hiroko、Sasaki Hiroshi、Yamamoto Naoki
- Journal Title
  
  Frontiers in Bioengineering and Biotechnology
  
  Volume: 8 Pages: 1-12
- DOI
  10.3389/fbioe.2020.00764
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06769
[Journal Article] Ophthalmic In Situ Gelling System Containing Lanosterol Nanoparticles Delays Collapse of Lens Structure in Shumiya Cataract Rats.2020
- Author(s)
  Nagai N, Umachi K, Otake H, Oka M, Hiramatsu N, Sasaki H, Yamamoto N.
- Journal Title
  
  Pharmaceutics.
  
  Volume: 12 (7) Issue: 7 Pages: 629-629
- DOI
  10.3390/pharmaceutics12070629
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09815, KAKENHI-PROJECT-18K06769
[Journal Article] Effect of a Lens Protein in Low-Temperature Culture of Novel Immortalized Human Lens Epithelial Cells (iHLEC-NY2).2020
- Author(s)
  Yamamoto N, Takeda S, Hatsusaka N, Hiramatsu N, Nagai N, Deguchi S, Nakazawa Y, Takata T, Kodera S, Hirata A, Kubo E, Sasaki H.
- Journal Title
  
  Cells.
  
  Volume: 9 (12) Issue: 12 Pages: 2670-2670
- DOI
  10.3390/cells9122670
- NAID
  130008066407
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09815, KAKENHI-PROJECT-20K11646, KAKENHI-PROJECT-17K13221
[Journal Article] The Intravitreal Injection of Lanosterol Nanoparticles Rescues Lens Structure Collapse at an Early Stage in Shumiya Cataract Rats2020
- Author(s)
  Nagai Noriaki、Fukuoka Yuya、Sato Kanta、Otake Hiroko、Taga Atsushi、Oka Mikako、Hiramatsu Noriko、Yamamoto Naoki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 3 Pages: 1048-1048
- DOI
  10.3390/ijms21031048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06769, KAKENHI-PROJECT-20K09815
[Journal Article] Novel Sustained-Release Drug Delivery System for Dry Eye Therapy by Rebamipide Nanoparticles2020
- Author(s)
  Nagai Noriaki、Ishii Miyu、Seiriki Ryotaro、Ogata Fumihiko、Otake Hiroko、Nakazawa Yosuke、Okamoto Norio、Kanai Kazutaka、Kawasaki Naohito
- Journal Title
  
  Pharmaceutics
  
  Volume: 12 Issue: 2 Pages: 155-155
- DOI
  10.3390/pharmaceutics12020155
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06769
[Journal Article] Hydrogel Formulations Incorporating Drug Nanocrystals Enhance the Therapeutic Effect of Rebamipide in a Hamster Model for Oral Mucositis.2020
- Author(s)
  Nagai N, Seiriki R, Deguchi S, Otake H, Hiramatsu N, Sasaki H, Yamamoto N.
- Journal Title
  
  Pharmaceutics.
  
  Volume: 12 (6) Issue: 6 Pages: 532-532
- DOI
  10.3390/pharmaceutics12060532
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09815, KAKENHI-PROJECT-18K06769
[Journal Article] Combination with l-Menthol Enhances Transdermal Penetration of Indomethacin Solid Nanoparticles2019
- Author(s)
  Nagai Noriaki、Ogata Fumihiko、Yamaguchi Mizuki、Fukuoka Yuya、Otake Hiroko、Nakazawa Yosuke、Kawasaki Naohito
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 15 Pages: 3644-3644
- DOI
  10.3390/ijms20153644
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06769
[Journal Article] 眼科DDSの必要性―点眼若による眼内疾患治療―2019
- Author(s)
  長井紀章
- Journal Title
  
  ファームプレス
  
  Volume: 6 Pages: 47-54
- Data Source
  KAKENHI-PROJECT-18K06769
[Journal Article] Therapeutic Effect of Cilostazol Ophthalmic Nanodispersions on Retinal Dysfunction in Streptozotocin-Induced Diabetic Rats.2017
- Author(s)
  Nagai N., Deguchi S., Otake H., Hiramatsu N., Yamamoto N.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 18 Issue: 9 Pages: 1971-1971
- DOI
  10.3390/ijms18091971
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11495, KAKENHI-PROJECT-15K08115
[Journal Article] Improvement of Dissolution Rate and Stability in a Pirenoxine Ophthalmic Suspension by the Bead Mill Methods2017
- Author(s)
  Ueno Akina、Yamaoka Sakie、Ito Yoshimasa、Kotake Takeshi、Nakazawa Yusuke、Nagai Noriaki
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 5 Pages: 635-641
- DOI
  10.1248/yakushi.16-00267
- NAID
  130005631439
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2017-05-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08115
[Journal Article] Co-administration of Magnesium Ion Prevents Indomethacin-Induced Intestinal Ulcerogenic Lesions in Adjuvant-Induced Arthritis Rats2017
- Author(s)
  Nagai Noriaki et al.
- Journal Title
  
  Biological & Pharmaceutical Bulletin
  
  Volume: 印刷中
- NAID
  130005688065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08115
[Journal Article] Co-instillation of nano-solid magnesium hydroxide enhances corneal permeability of dissolved timolol2017
- Author(s)
  Nagai Noriaki、Ogata Fumihiko、Otake Hiroko、Kawasaki Naohito、Nakazawa Yosuke、Kanai Kazutaka、Okamoto Norio、Shimomura Yoshikazu
- Journal Title
  
  Experimental Eye Research
  
  Volume: 165 Pages: 118-124
- DOI
  10.1016/j.exer.2017.10.002
- Data Source
  KAKENHI-PROJECT-15K08115
[Journal Article] NSAIDsのベネフィットとリスク. 長井紀章NSAIDs起因性消化管障害の制御を目指した製剤工夫2017
- Author(s)
  Nagai Noriaki
- Journal Title
  
  BIO Clinica
  
  Volume: 32 Pages: 1099-1101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08115
[Journal Article] A Nanoparticle-based Ophthalmic Formulation of Dexamethasone Enhances Corneal Permeability of the Drug and Prolongs its Corneal Residence Time2017
- Author(s)
  Nagai Noriaki et al.
- Journal Title
  
  Biological & Pharmaceutical Bulletin
  
  Volume: 印刷中
- NAID
  130006846424
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08115
[Journal Article] Ophthalmic formulation containing nilvadipine nanoparticles prevents retinal dysfunction in rats Injected with streptozotocin.2017
- Author(s)
  Deguchi S., Otake H., Nakazawa Y., Hiramatsu N., Yamamoto N., Nagai N.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 18 Issue: 12 Pages: 2720-2720
- DOI
  10.3390/ijms18122720
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11495, KAKENHI-PROJECT-15K08115
[Journal Article] Effects of Ophthalmic Formulations containing Cilostazol Nanoparticles on Retinal Vasoconstriction in Rats Injected with Endothelin-12015
- Author(s)
  Nagai Noriaki, Ito Yoshimasa et al.
- Journal Title
  
  Pharmaceutica Analytica Acta
  
  Volume: 6 Issue: 04 Pages: 1-8
- DOI
  10.4172/2153-2435.1000351
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460243
[Journal Article] Topical Therapies for Rheumatoid Arthritis by Gel Ointments containing Indomethacin Nanoparticles in Adjuvant-Induced Arthritis Rat2015
- Author(s)
  Nagai Noriaki et al.
- Journal Title
  
  J. Oleo Sci.
  
  Volume: 64 Issue: 3 Pages: 337-346
- DOI
  10.5650/jos.ess14170
- NAID
  130004800116
- ISSN
  1345-8957, 1347-3352
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08115
[Journal Article] Pharmacokinetics and Antiinflammatory Effect of a Novel Gel System Containing Ketoprofen Solid Nanoparticles2015
- Author(s)
  Nagai Noriaki et al.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 38 Issue: 12 Pages: 1918-1924
- DOI
  10.1248/bpb.b15-00567
- NAID
  130005112631
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08115
[Journal Article] Excessive Interleukin 18 Relate the Aggravation of Indomethacin-Induced Intestinal Ulcerogenic Lesions in Adjuvant-Induced Arthritis Rat2015
- Author(s)
  Nagai Noriaki et al.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 38 Issue: 10 Pages: 1580-1590
- DOI
  10.1248/bpb.b15-00375
- NAID
  130005101573
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08115
[Journal Article] Effects of Ophthalmic Formulations containing Cilostazol Nanoparticles on Retinal Vasoconstriction in Rats Injected with Endothelin-12015
- Author(s)
  Nagai Noriaki
- Journal Title
  
  Pharmaceutica Analytica Acta
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860129
[Journal Article] Improved corneal toxicity and permeability of tranilast by the preparation of ophthalmic formulations containing its nanoparticles2014
- Author(s)
  Nagai Noriaki
- Journal Title
  
  Journal of Oleo Science
  
  Volume: 63 Pages: 177-186
- NAID
  130004436107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860129
[Journal Article] A nanoparticle formulation reduces the corneal toxicity of indomethacin eye drops and enhances its corneal permeability2014
- Author(s)
  Nagai Noriaki, Ito Yoshimasa, Okamoto Norio, Shimomura Yoshikazu
- Journal Title
  
  Toxicology
  
  Volume: 319 Pages: 53-62
- DOI
  10.1016/j.tox.2014.02.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460243
[Journal Article] Reduction of Enhanced Rabbit Intraocular Pressure by Instillation of Pyroglutamic Acid Eye Drops2013
- Author(s)
  Ito Yoshimasa, Nagai Noriaki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 36 Issue: 6 Pages: 1017-1023
- DOI
  10.1248/bpb.b13-00159
- NAID
  130003361452
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590208
[Journal Article] Reduction of Enhanced Rabbit Intraocular Pressure by Instillation of Pyroglutamic Acid Eye Drops2013
- Author(s)
  Ito Y., Nagai N., Okamoto N., Shimomura Y., Nakanishi K., Tanaka R
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume: 36 (Highlighted paper selected by Editor-in-Chief) Pages: 1017-1023
- NAID
  130003361452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590208
[Journal Article] Dysfunction in Cytochrome c Oxidase Caused by Excessive Nitric Oxide in Human Lens Epithelial Cells Stimulated with Interferon-□and Lipopolysaccharide2012
- Author(s)
  Nagai N., Ito Y.
- Journal Title
  
  Curr Eye Res.
  
  Volume: 37 Pages: 889-897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790678
[Journal Article] Dysfunction in Cytochrome c Oxidase Caused by Excessive Nitric Oxide in Human Lens Epithelial Cells Stimulated with Interferon-γ and Lipopolysaccharide2012
- Author(s)
  Nagai Noriaki
- Journal Title
  
  Current Eye Research
  
  Volume: 37 Issue: 10 Pages: 889-897
- DOI
  10.3109/02713683.2012.689070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790678
[Journal Article] 過酸化水素に対する感受性と防御力が水晶体白濁に及ぼす影響2011
- Author(s)
  Nagai Noriaki
- Journal Title
  
  Biological & Pharmaceutical Bulletin
  
  Volume: 34 Pages: 1005-1010
- Data Source
  KAKENHI-PROJECT-23790678
[Journal Article] Correlation between Hyper-Sensitivity to Hydrogen Peroxide and Low Defense against Ca^<2+> Influx in Cataractogenic Lens of ICR/f Rats2011
- Author(s)
  Nagai N., Ito Y, Takeuchi N
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 34 Pages: 1005-1010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790678
[Presentation] ピノレキシン点眼液は亜セレン酸ナトリウム誘発水晶体物性変化を改善する2023
- Author(s)
  門脇玲太、浅井拓己、出口粧央里、大竹裕子、中澤洋介、山本直樹、長井紀章
- Organizer
  第62回日本白内障学会総会・第49回水晶体研究会
- Data Source
  KAKENHI-PROJECT-23K09017
[Presentation] 老視予防を目指して：亜セレン酸ナトリウム投与に伴う水晶体の硬化とその評価法の提案2023
- Author(s)
  久保田ちか、門脇玲太、浅井拓己、大竹裕子、中澤洋介、山本直樹、長井紀章
- Organizer
  第33回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-23K09017
[Presentation] Promotional Effect of Minoxidil Nanoparticles on Hair Growth in C57BL/6 Mice2023
- Author(s)
  Noriaki Nagai, Yoshihiro Oaku, Akinari Abe, Yajima Yuya, Fuka Sasaki, Chika Kubota, Sorato Shiroyama, Naoki Yamamoto
- Organizer
  The Federation of Asian Pharmaceutical Associations (FAPA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K09017
[Presentation] 老視予防法の確立を目指して－ニルバジピンナノサスペンション点眼による亜セレン酸ナトリウム誘発ラット水晶体硬化の抑制－2023
- Author(s)
  浅井拓己, 門脇玲太, 出口粧央里, 大竹裕子, 岡本紀夫, 中澤洋介, Misra Manju, 長井紀章
- Organizer
  第73回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K06656
[Presentation] ブレイクダウン法を用いた固体ナノ分散体の製造に関する研究：結晶形の制御はインドメタシンの破砕効率を高める2023
- Author(s)
  増田柊也, 後藤涼花, 衣川美宇, 矢野詩歩, 曽谷月香, 大竹裕子, 長井紀章.
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K06656
[Presentation] ドライアイ療法への応用を目指した眼瞼適用トロキシピドナノ製剤の開発2023
- Author(s)
  小坂太陽, 渡辺彩花, 板橋瑞稀, 油納美和, 大竹裕子, 長井紀章, 岡本紀夫
- Organizer
  第33回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-21K06656
[Presentation] クリスタルエンジニアリングに基づくインドメタシンナノ点眼製剤の開発－物性測定とOcular Bioavailabilityの評価－2023
- Author(s)
  曽谷月香, 増田柊也, 矢野詩歩, 田所朋久, 大竹裕子, 岡本紀夫, 中澤洋介, Misra Manju, 長井紀章
- Organizer
  第73回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K06656
[Presentation] Fenofibrate Nanosuspensionの製造と眼科薬領域への展開：点眼による網膜疾患治療2022
- Author(s)
  出口粧央里, 後藤涼花, 大竹裕子, 花栗潤哉, 横田陽匡, 山上聡, 長岡泰司, 長井紀章
- Organizer
  第47回製剤・創剤セミナー
- Data Source
  KAKENHI-PROJECT-21K06656
[Presentation] Irbesartan Nanosuspensions Increase Oral Bioavailability by Improving Drug Solubility and Leading Endocytosis Uptake into the Intestine2022
- Author(s)
  Noriaki Nagai, Ayari Ike, Yurisa Shimomae, Hanano Osako, Hiroko Otake
- Organizer
  WCOS2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06656
[Presentation] 湿式破砕法による薬物ナノ結晶化はBCSクラス4であるフロセミドの経口吸収性を改善する2022
- Author(s)
  出口粧央里, 大迫華乃, 池彩里, 下前憂梨咲, 大竹裕子, 長井紀章
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K06656
[Presentation] 高温環境での核白内障発症におけるTRPVチャネルの関与．2022
- Author(s)
  中澤洋介、嶋田響、工野由美香、多胡めぐみ、平松範子、山本直樹、長井紀章、武田峻、永田万由美、佐々木洋．
- Organizer
  第61回日本白内障学会総会・第48回水晶体研究会合同学会
- Data Source
  KAKENHI-PROJECT-20K09815
[Presentation] TRPVチャネルを介したEMT抑制メカニズムの解析．2022
- Author(s)
  中澤洋介、杉山裕紀、河田沙礼、長井紀章、山本直樹、Rosica Petrova、Paul Donaldson、多胡めぐみ．
- Organizer
  第42回日本眼薬理学会
- Data Source
  KAKENHI-PROJECT-20K09815
[Presentation] 眼圧及び網膜障害を同時標的とした緑内障治療薬の開発：チロキサポール配合ブリンゾラミドナノサスペンションの有用性2022
- Author(s)
  後藤涼花, 出口粧央里, 櫻井達真, 衣川美宇, 明和亮伍, 矢野詩歩, 増田柊也, 岡本紀夫, 金井一亨, 長井紀章
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K06656
[Presentation] ニルバジピンとラノステロールナノ分散点眼液による亜セレン酸白内障の再透明化2022
- Author(s)
  後藤涼花, 山田茂裕, 門脇玲太, 平松範子, 山本直樹, 佐々木洋, 松永透, 小早川信一郎, 長井紀章
- Organizer
  第61回日本白内障学会総会・第48回水晶体研究会
- Data Source
  KAKENHI-PROJECT-21K06656
[Presentation] 関節リウマチ患者への安心・安全な適用を目指したセレコキシブナノ結晶の作成2022
- Author(s)
  出口粧央里, 河野佑紀, 岩上歩紗, 辻際瑞希, 大竹裕子, 長井紀章
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-21K06656
[Presentation] 温度の違いがヒト水晶体中ミトコンドリア機能へ及ぼす影響：高環境温度はATPの過剰産生を誘発する2021
- Author(s)
  長井紀章, 武田峻, 出口粧央里, 山本直樹, 中澤洋介, 高田匠, 宮田佳樹, 平松範子, 永田万由美, 久保江理, 佐々木洋
- Organizer
  第60回日本白内障学会総会・第47回水晶体研究会
- Data Source
  KAKENHI-PROJECT-20K09815
[Presentation] ナノ結晶とin situ gellingシステムからなる眼科用トラニラストナノ製剤の開発2021
- Author(s)
  南実沙, 宇野樹, 大竹裕子, 金井一享, 岡本紀夫, 長井紀章
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-21K06656
[Presentation] レバミピドナノ結晶封入ハイドロゲルは口腔粘膜炎の修復を高める2021
- Author(s)
  出口粧央里, 勢力諒太朗, 吉岡涼, 西田未来, 大竹裕子, 山本直樹, 長井紀章
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K09815
[Presentation] 体温と白内障病型および水晶体エネルギー代謝との関係2021
- Author(s)
  武田峻, 山本直樹, 長井紀章, 出口粧央里, 柴田哲平, 初坂奈津子, 平田晃正, 久保江理, 佐々木洋
- Organizer
  第125回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-20K09815
[Presentation] ストレプトゾトシン誘発視機能障害に対するブリンゾラミドナノ点眼液の有用性評価2021
- Author(s)
  南実沙, 後藤涼花, 櫻井達真, 明和亮伍, 衣川美宇, 出口粧央里, 大竹裕子, 長井紀章
- Organizer
  第41回日本眼薬理学会
- Data Source
  KAKENHI-PROJECT-21K06656
[Presentation] 効果的な緑内障治療を可能とするブリンゾラミドナノ点眼薬の開発2021
- Author(s)
  衣川美宇, 井阪匠, 後藤涼花, 大竹裕子, 岡本紀夫, 長井紀章
- Organizer
  第71回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K06656
[Presentation] 培養温度の違いによるヒト不死化水晶体上皮細胞（iHLEC-NY2）の遺伝子・蛋白質への影響（優秀演題受賞）2021
- Author(s)
  山本直樹, 平松範子, 長井紀章, 中澤洋介, 高田匠, 宮田佳樹, 武田峻, 永田万由美, 松島博之, 久保江理, 佐々木洋
- Organizer
  第60回日本白内障学会総会・第47回水晶体研究会
- Data Source
  KAKENHI-PROJECT-20K09815
[Presentation] ブリンゾラミドナノ点眼薬の調製と網膜障害治療への応用2021
- Author(s)
  明和亮伍, 森本泰光, 櫻井達真, 大竹裕子, 岡本紀夫, 長井紀章
- Organizer
  第71回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K06656
[Presentation] 新規ヒト不死化水晶体上皮細胞を用いた培養温度の違いによる水晶体蛋白質への影響2021
- Author(s)
  山本直樹, 長井紀章, 中澤洋介, 平松範子, 髙田匠, 武田峻, 桶本孟, 石田秀俊, 宮下久範, 柴田哲平, 初坂奈津子, 平田晃正, 久保江理, 佐々木洋
- Organizer
  第125回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-20K09815
[Presentation] トラニラストナノ結晶封入 in situ gel処方間における薬物放出挙動に関する研究2021
- Author(s)
  北村優夏, 南実沙, 大竹裕子, 金井一亨, 長井紀章
- Organizer
  日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K06656
[Presentation] 不死化ヒト水晶体上皮細胞の三次元細胞凝集体とSoemmering's ring との構造比較.2020
- Author(s)
  平松範子, 長井紀章, 近藤征史, 今泉和良, 佐々木洋, 山本直樹.
- Organizer
  第52回日本臨床分子形態学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K09815
[Presentation] ショットガンプロテオミクス解析を用いたSCR水晶体混濁要因の解析.2020
- Author(s)
  長井紀章, 山本哲志, 大竹裕子, 平松範子, 山本直樹, 酒井裕子, 岡美佳子, 多賀淳.
- Organizer
  第59回日本白内障学会総会・第46回水晶体研究会
- Data Source
  KAKENHI-PROJECT-20K09815
[Presentation] 経眼瞼適用レバミピドナノゲル製剤によるドライアイ治療2020
- Author(s)
  南実沙, 石井美有, 勢力諒太朗, 大竹裕子, 平松範子, 山本直樹, 長井紀章
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-18K06769
[Presentation] ニルバジピンナノ結晶点眼製剤の開発：遺伝子白内障ラットSCRにおける水晶体混濁進行抑制効果.2020
- Author(s)
  山田茂裕, 馬地一稀, 福岡侑也, 大竹裕子, 平松範子, 山本直樹, 酒井裕子, 岡美佳子, 長井紀章.
- Organizer
  第59回日本白内障学会総会・第46回水晶体研究会
- Data Source
  KAKENHI-PROJECT-20K09815
[Presentation] ニルバジピンナノ結晶点眼製剤の開発：遺伝性白内障ラットSCRにおける水晶体混濁進行抑制効果2020
- Author(s)
  山田茂裕, 馬地一稀, 福岡侑也, 大竹裕子, 平松範子, 山本直樹, 酒井裕子, 岡美佳子,長井紀章
- Organizer
  第59回日本白内障学会総会・第46回水晶体研究会
- Data Source
  KAKENHI-PROJECT-18K06769
[Presentation] l-メントールによるインドメタシンナノ結晶製剤の経皮吸収促進効果とその透過機序の解明2020
- Author(s)
  山口瑞季, 福岡侑也, 永福紡, 川口陽菜子, 原雅紀, 大竹裕子, 長井紀章
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06769
[Presentation] ナノ結晶点眼製剤による新規結膜炎治療薬の確立：トラニラストナノ結晶点眼液の抗炎症効果2020
- Author(s)
  南実沙, 山﨑由夏, 蛭子小春, 宇野樹, 大竹裕子, 長井紀章
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06769
[Presentation] 新規経眼瞼レバミピドナノ製剤の開発－家兎涙液眼表面崩壊に対する保護効果とドライアイ治療への応用－2019
- Author(s)
  石井美有, 勢力諒太郎, 大竹裕子, 長井紀章
- Organizer
  第69回日本薬学会関西支部総会・大会, 兵庫
- Data Source
  KAKENHI-PROJECT-18K06769
[Presentation] ナノ化技術を核としたラノステロールの製剤化研究：遺伝性白内障ラットSCRにおける治療効果2019
- Author(s)
  福岡侑也, 馬地一稀, 大竹裕子, 佐藤完太, 多賀淳, 岡美佳子, 平松範子, 山本直樹, 長井紀章
- Organizer
  第58回日本白内障学会・第45回水晶体研究会
- Data Source
  KAKENHI-PROJECT-18K06769
[Presentation] インドメタシン点眼製剤の開発研究：PluronicF-127は薬物ナノ結晶の角膜透過性を高める2019
- Author(s)
  石神太佐, 本多公貴, 岡森那々海, 大竹裕子, 長井紀章
- Organizer
  第69回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-18K06769
[Presentation] Endocytosis is Responsible for Drug Transcorneal Penetration Following the Instillation of Ophthalmic Formulations containing Indomethacin Nanoparticles2019
- Author(s)
  Nagai Noriaki, Ogata Fumihiko, Otake Hiroko, Nakazawa Yosuke, Kawasaki Naohito
- Organizer
  Asian Federation for Pharmaceutical Sciences Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06769
[Presentation] ニルバジピンナノ結晶点眼製剤の抗白内障作用：ストレプトゾトシン誘発糖尿病性白内障ラットに対する有用性評価2019
- Author(s)
  南実沙, 出口粧央里, 福岡侑也, 馬地一稀, 大竹裕子, 平松範子, 山本直樹, 長井紀章
- Organizer
  第58回日本白内障学会・第45回水晶体研究会
- Data Source
  KAKENHI-PROJECT-18K06769
[Presentation] Enhancement in Corneal Permeability of Dissolved Carteolol by Its Combinaiton with magnesium hydroxide nanoparticles2019
- Author(s)
  Fukuoka Yuya, Deguchi Saori, Ishii Miyu, Otake Hiroko, Okamoto Norio, Shimomura Yoshikazu, Nagai Noriaki
- Organizer
  Asian Federation for Pharmaceutical Sciences Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06769
[Presentation] Co-instillation of Nano-solid Magnesium Hydroxide Enhances Corneal Permeability of Dissolved Timolol2019
- Author(s)
  Ishii Miyu, Okamori Nanami, Fukuoka Yuya, Otake Hiroko, Kanai Kazutaka, Nagai Noriaki
- Organizer
  Asian Federation for Pharmaceutical Sciences Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06769
[Presentation] ナノ結晶による眼科DDS（ドラッグデリバリー・システム）―前眼部・抗眼部への薬物供給と眼疾患の治療―2018
- Author(s)
  長井紀章
- Organizer
  日本獣医眼科カンファランスJVOC2018年年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06769
[Presentation] Therapeutic Effect of Ophthalmic Formulation containing Nilvadipine Nanoparticles on Retinal Dysfunction in Rats Injected with Streptozotocin2018
- Author(s)
  Noriaki Nagai, Saori Deguchi, Miyu Ishii, Yuya Fukuoka, Hiroko Otake, Yosuke Nakazawa
- Organizer
  The Association for Research in Vision and Oththlmology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06769
[Presentation] ナノ点眼持続性製剤の確立に関する研究：増粘剤添加が薬物ナノ粒子の角膜滞留性・眼内移行量へ与える影響2018
- Author(s)
  本田公貴, 岡森那々海, 大竹裕子, 金井一享, 岡本紀夫, 長井紀章
- Organizer
  第68回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-18K06769
[Presentation] シロスタゾールナノ硝子体内投与製剤の開発：薬物動態と視機能改善効果の測定2018
- Author(s)
  今岡未奈, 國松紬, 大竹裕子, 長井紀章
- Organizer
  第68回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-18K06769
[Presentation] NSAIDs起因性消化管障害の制御を目指した製剤工夫：メロキシカムナノ結晶製剤の開発2017
- Author(s)
  石井美有、大竹裕子、長井紀章
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-15K08115
[Presentation] インドメタシンナノ結晶からなる口腔内崩壊錠の製造と小腸粘膜透過機構の解明2017
- Author(s)
  中村翼、谷野令奈、大竹裕子、長井紀章
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-15K08115
[Presentation] レバミピドナノ結晶製剤の開発とインドメタシン惹起消化管障害に対する治療効果2017
- Author(s)
  上田純也、大竹裕子、長井紀章
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-15K08115
[Presentation] 経眼瞼適用製剤”の開発：マイボーム腺分泌産物（マイバム）を介した新たな薬物涙液送達メカニズムの解明2016
- Author(s)
  上野祥奈，長井紀章，伊藤吉將，岡本紀夫，下村嘉一
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪（大阪薬科大学）
- Data Source
  KAKENHI-PROJECT-26460243
[Presentation] ナノ化技術を用いたメロキシカム経口製剤の開発とその有用性評価2016
- Author(s)
  真野裕、山岡大起、上田利香、長井紀章、伊藤吉將
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K08115
[Presentation] ケトプロフェン・ナノ結晶を用いた新規経皮適用製剤の設計とその有用性評価2016
- Author(s)
  岩前亜弥、長井紀章、伊藤吉將、松井誠、森本英二
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K08115
[Presentation] 水湿式ビーズミルによる難溶解性薬物のナノ粒子化の検討：セルロース系添加物がビーズミル破砕効率に与える影響2016
- Author(s)
  上田利香，山岡大起，真野裕，長井紀章，伊藤吉將
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学（大阪）
- Data Source
  KAKENHI-PROJECT-15K08115
[Presentation] 高感度マイクロフィルタリング法を用いたマイボーム腺分泌型トラニストの涙液中薬物量の全自動測定法2016
- Author(s)
  伊藤吉將，上野祥奈，石井美有，長井紀章，多賀淳，松井誠，守本英二
- Organizer
  第27回マイクロダイアリシス研究会
- Place of Presentation
  東京（お茶の水大学）
- Data Source
  KAKENHI-PROJECT-26460243
[Presentation] トラニラストナノ結晶を用いた新規経眼瞼適用製剤の設計とその涙液移行性評価2016
- Author(s)
  上野祥奈、長井紀章、伊藤吉將、岡本紀夫、下村嘉一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460243
[Presentation] メロキシカムナノ結晶を用いた新規経口製剤の創製　―バイオアベイラビリティの向上と副作用軽減―2015
- Author(s)
  真野裕、山岡大起、上田利香、長井紀章、伊藤吉將
- Organizer
  第65回日本薬学会近畿支部総会・大会,
- Place of Presentation
  大阪大谷大学（大阪）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15K08115
[Presentation] トラニラストナノ結晶を用いた眼軟膏剤の設計とその有用性2015
- Author(s)
  上野祥奈、長井紀章、伊藤吉將、岡本紀夫、下村嘉一
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪大谷大学（大阪）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26460243
[Presentation] 眼圧降下と網膜症治療を同時標的とした次世代緑内障治療薬“医薬品ナノ結晶点眼製剤”の開発2014
- Author(s)
  長井　紀章
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本（熊本大学）
- Data Source
  KAKENHI-PROJECT-25860129
[Presentation] ナノ化技術を応用した眼瞼適用ゲルパッチ「貼るめぐすり」の開発とその有効性2014
- Author(s)
  吉岡千晶,長井紀章,伊藤吉將,高橋秀也,志水英二,松井誠,守本英二
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23590208
[Presentation] 網膜疾患治療を目的とした医薬品ナノ結晶点眼製剤の開発2013
- Author(s)
  長井　紀章
- Organizer
  第63回日本薬学会近畿支部総会・大会
- Place of Presentation
  同志社女子大学（京都府）
- Data Source
  KAKENHI-PROJECT-25860129
[Presentation] ヒト水晶体上皮細胞株 SRA01/04での一酸化窒素過剰産生がミトコンドリア機能へ与える影響2012
- Author(s)
  長井紀章,楠山侑里,伊藤吉將
- Organizer
  第38回水晶体研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790678
[Presentation] Adverse Effect of Excessive Nitric Oxide on Cytochrome c Oxidase in UPL Rat Lens and Human Lens Epithelial Cells2012
- Author(s)
  Nagai Noriaki
- Organizer
  XX International Congress of Eye Research
- Place of Presentation
  ベルリン（ドイツ）
- Data Source
  KAKENHI-PROJECT-23790678
[Presentation] Adverse Effect of Excessive Nitric Oxide on Cytochrome c Oxidase in UPL Rat Lens and Human Lens Epithelial Cells2012
- Author(s)
  Nagai N., Ito Y.
- Organizer
  XX InternationalCongress of Eye Research
- Place of Presentation
  Berlin,Germany
- Data Source
  KAKENHI-PROJECT-23790678
[Presentation] ヒト水晶体上皮細胞株SRA01/04での一酸化窒素過剰産生がミトコンドリア機能へ与える影響
- Author(s)
  長井　紀章
- Organizer
  第38回水晶体研究会
- Place of Presentation
  慶応大学薬学部（東京都）
- Data Source
  KAKENHI-PROJECT-23790678

1. ITO Yoshimasa (50128633)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. Yamamoto Naoki (00267957)

# of Collaborated Projects: 2 results

# of Collaborated Products: 31 results
3. 平松範子 (10802209)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
4. 大熊真人 (50329710)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 長岡泰司 (00333691)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 堀口正之 (70209295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 櫛山暁史 (30435820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 横田陽匡 (60431417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 木村航 (60452182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 加藤由布 (50773412)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. IMAIZUMI Kazuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 中澤洋介

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results

Nagai Noriaki 長井 紀章

NAGAI Noriaki 長井 紀章

Research Projects

Research Products

Co-Researchers

薬物ナノ粒子化技術を基盤としたコンタクト型デバイスの開発と網膜症治療への応用Principal Investigator

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Overcoming Diabetic Retinopathy through Local Control of Oxidative Stress

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Regeneration of Retina with Physiological Functions by Hybrid Culture and Evaluation of Drugs / Production of Novel iPS Cells for Transplantation.

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Novel Treatment of Nano-eyedrop for Diabetic retinopathy

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Design of ophthalmic in situ gel incorporating solid nanoparticles for therapy of retinal diseasePrincipal Investigator

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Development of three-dimensional retinal regeneration with electrophysiological function and drug safety evaluation using the human iris derived iPS cells

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Design of new ophthalmic formulations based on drug nanoparticles and it's application for therapy of retinopathyPrincipal Investigator

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Design of novel nanomedicine containing NSAIDs for improvement of drug-induced gastrointestinal lesionsPrincipal Investigator

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Design of transdermal ophthalmic therapy using drug nanoparticle technology and application of it as eye infection treatment

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Ophthalmic formulation of solid nanoparticles permits the retinal therapy, and lead to the therapy in the glaucoma patientPrincipal Investigator

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Development of the effective ophthalmic formulations that simultaneously targeting intraocular pressure and optic nerve

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Early prediction of senile cataract based on the elucidation of mitochondrial DNAPrincipal Investigator

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[Journal Article] Therapeutic Effects of Hydrogel Formulations Incorporating Troxipide Nanoparticles on Oral Mucositis in Hamsters.2023

Author(s)

Journal Title

Nagai Noriaki 長井紀章

NAGAI Noriaki 長井紀章