HIRATA Hiroaki 平田宏聡

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Hirata Hiroaki 平田宏聡

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Researcher Number	90414028
Other IDs
Affiliation (Current)	2025: 金沢工業大学, バイオ・化学部, 教授
Affiliation (based on the past Project Information) *help	2025: 金沢工業大学, バイオ・化学部, 教授 2021 – 2023: 金沢工業大学, バイオ・化学部, 教授 2019 – 2021: 名古屋大学, 医学系研究科, 特任講師
Review Section/Research Field	Principal Investigator Basic Section 90110:Biomedical engineering-related / Transformative Research Areas, Section (III) / 0702:Biology at cellular to organismal levels, and related fields Except Principal Investigator Transformative Research Areas, Section (III)
Keywords	Principal Investigator メカノバイオロジー / アドヘレンスジャンクション / 細胞増殖 / 牽引力 / 表皮癌細胞 / 3次元培養 / がん細胞塊 / 圧縮刺激 / グリオーマ / 力学刺激 … More / 力学相互作用 / スフェロイド / 三次元培養 / 腫瘍細胞塊 / 上皮細胞 / 組織伸展 / アクトミオシンファイバー / FAK / 焦点接着斑 / Rac1 / 葉状仮足 / 細胞協同現象 … More Except Principal Investigator 研究会 / 冠ワークショップ / 研究者ネットワーク / 領域会議 / 冠シンポジウム / 総括班 / 脳神経科学 / メカノセンシング Less

The mechanical interaction paradox between cancer cell aggregates and 3D extracellular matrix and its effect on aggregate growthPrincipal Investigator
- Principal Investigator
  
  平田宏聡
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Kanazawa Institute of Technology
Promotion of Pressio-Neuroscience
- Principal Investigator
  
  Nonomura Keiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Tokyo Institute of Technology
  National Institute for Basic Biology
Compressive stress against brain tumors: its effect on tumor cell growth and the underlying molecular mechanismPrincipal Investigator
- Principal Investigator
  
  Hirata Hiroaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kanazawa Institute of Technology
Tissue deformation-dependent regulation of cell proliferation: distinct roles of cell-substrate and cell-cell adhesionsPrincipal Investigator
- Principal Investigator
  
  Hiroaki Hirata
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Kanazawa Institute of Technology
  Nagoya University
Mechanism for coordination of cell motility and proliferation in epithelial cells: role of intercellular mechanical interactionPrincipal Investigator
- Principal Investigator
  
  Hirata Hiroaki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0702:Biology at cellular to organismal levels, and related fields
- Research Institution
  Nagoya University

All 2023 2022 2021 2020 2019

All Journal Article Presentation Book

[Book] Material-based Mechanobiology, CHAPTER 4 Measurement and Manipulation of Cellular Forces Using Silicone Elastomers2022
- Author(s)
  Hiroaki Hirata, Masahiro Sokabe
- Total Pages
  21
- Publisher
  The Royal Society of Chemistry
- Data Source
  KAKENHI-PLANNED-21H05127
[Journal Article] Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments2023
- Author(s)
  Torii Takeru、Sugimoto Wataru、Itoh Katsuhiko、Kinoshita Natsuki、Gessho Masaya、Goto Toshiyuki、Uehara Ikuno、Nakajima Wataru、Budirahardja Yemima、Miyoshi Daisuke、Nishikata Takahito、Tanaka Nobuyuki、Hirata Hiroaki、Kawauchi Keiko
- Journal Title
  
  Cell Death & Disease
  
  Volume: 14 Issue: 11 Pages: 766-766
- DOI
  10.1038/s41419-023-06310-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08293, KAKENHI-PLANNED-21H05127, KAKENHI-PROJECT-21H02062
[Journal Article] Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers2023
- Author(s)
  Katsuta Hiroki、Okuda Satoru、Nagayama Kazuaki、Machiyama Hiroaki、Kidoaki Satoru、Kato Masashi、Sokabe Masahiro、Miyata Takaki、Hirata Hiroaki
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 3 Pages: 106090-106090
- DOI
  10.1016/j.isci.2023.106090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17KT0033, KAKENHI-PROJECT-21K18326, KAKENHI-PROJECT-22K19890, KAKENHI-PROJECT-22KK0145, KAKENHI-PLANNED-21H05127, KAKENHI-PROJECT-21H02656, KAKENHI-PROJECT-21H03804, KAKENHI-PROJECT-20K12596, KAKENHI-PROJECT-19H01147, KAKENHI-PUBLICLY-21H00363, KAKENHI-PLANNED-22H05170, KAKENHI-PROJECT-19H05627
[Journal Article] Editorial: Multicellularity: Views from cellular signaling and mechanics2023
- Author(s)
  Hirata Hiroaki、Nakazawa Naotaka、Hirashima Tsuyoshi、Ravasio Andrea
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 11 Pages: 1-3
- DOI
  10.3389/fcell.2023.1172921
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05126, KAKENHI-PLANNED-21H05127, KAKENHI-PROJECT-20K12596, KAKENHI-PROJECT-18K14819
[Journal Article] Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells2021
- Author(s)
  Dobrokhotov Oleg、Sunagawa Masaki、Torii Takeru、Mii Shinji、Kawauchi Keiko、Enomoto Atsushi、Sokabe Masahiro、Hirata Hiroaki
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 9 Pages: 728383-728383
- DOI
  10.3389/fcell.2021.728383
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12596, KAKENHI-PLANNED-21H05127
[Journal Article] Cell mechanosensing underlies homeostasis of multicellular systems2020
- Author(s)
  Nonomura Keiko、Hirata Hiroaki
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 17 Issue: 0 Pages: 100-102
- DOI
  10.2142/biophysico.BSJ-2020019
- NAID
  130007919803
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12596, KAKENHI-PROJECT-19K23748
[Journal Article] Tension-dependent Generation of Biochemical Signals on Actomyosin Fibers2020
- Author(s)
  Hiroaki Hirata、Masahiro Sokabe
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 60 Issue: 2 Pages: 089-093
- DOI
  10.2142/biophys.60.089
- NAID
  130007818289
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23748
[Journal Article] MMP24 as a Target of YAP Is a Potential Prognostic Factor in Cancer Patients2020
- Author(s)
  Wataru Sugimoto、Katsuhiko Itoh、Hiroaki Hirata、Yoshinori Abe、Takeru Torii、Yasumasa Mitsui、Yemima Budirahardja、Nobuyuki Tanaka、Keiko Kawauchi
- Journal Title
  
  Bioengineering
  
  Volume: 7 Issue: 1 Pages: 18-18
- DOI
  10.3390/bioengineering7010018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23748, KAKENHI-PROJECT-17H04054, KAKENHI-PROJECT-19J21096, KAKENHI-PROJECT-18K06231
[Journal Article] 細胞増殖の接触阻害における物理的因子の役割2020
- Author(s)
  平田宏聡、Oleg Dobrokhotov、曽我部正博
- Journal Title
  
  実験医学
  
  Volume: 38 Pages: 93-99
- Data Source
  KAKENHI-PROJECT-19K23748
[Journal Article] Coordination between Cell Motility and Cell Cycle Progression in Keratinocyte Sheets via Cell-Cell Adhesion and Rac12020
- Author(s)
  Hirata Hiroaki、Dobrokhotov Oleg、Sokabe Masahiro
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 11 Pages: 101729-101729
- DOI
  10.1016/j.isci.2020.101729
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12596, KAKENHI-PROJECT-19K23748
[Presentation] PIEZO1-mediated mechanosensation controls multiple events during brain development2023
- Author(s)
  Keiko Nonomura, Mayumi Okamoto, Naotaka Nakazawa, Hiroaki Hirata
- Organizer
  第46回日本分子生物学会年会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05124
[Presentation] PIEZO1メカノセンサーチャネルの脳発生における役割の解析2023
- Author(s)
  野々村恵子、岡本麻友美、平田宏聡、中澤直高
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-21H05127
[Presentation] alpha-アクチニンはストレスファイバーのメカニクスを変化させることで収縮力の伝達を調節している2023
- Author(s)
  勝田紘基、奥田覚、長山和亮、町山裕亮、木戸秋悟、宮田卓樹、曽我部正博、平田宏聡
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-21H05127
[Presentation] alpha-アクチニンによって調節されるストレスファイバーの物性はミオシン由来の力の伝達効率を調節する2023
- Author(s)
  勝田紘基、奥田覚、長山和亮、町山裕亮、加藤昌志、曽我部正博、宮田卓樹、木戸秋悟、平田宏聡
- Organizer
  日本生物物理学会第61回年会
- Invited
- Data Source
  KAKENHI-PLANNED-21H05127
[Presentation] Distinct roles of cell-cell and cell-ECM adhesions in mechanical regulation of epidermal cancer cell proliferation2023
- Author(s)
  平田宏聡、Oleg Dobrokhotov、曽我部正博
- Organizer
  日本生物物理学会第61回年会
- Invited
- Data Source
  KAKENHI-PLANNED-21H05127
[Presentation] 細胞接着境界の力学状態による表皮がん細胞の増殖制御2023
- Author(s)
  平田宏聡
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-21H05127
[Presentation] 張力繊維に沿った力の伝達効率はa-アクチニンの架橋によって変化する機械的特性に依存している2022
- Author(s)
  勝田紘基、奥田覚、長山和亮、町山裕亮、木戸秋悟、加藤昌志、曽我部正博、宮田卓樹、平田宏聡
- Organizer
  第45回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K12596
[Presentation] 張力繊維に沿った力の伝達効率はa-アクチニンの架橋によって変化する機械的特性に依存している2022
- Author(s)
  勝田紘基、奥田覚、長山和亮、町山裕亮、木戸秋悟、加藤昌志、曽我部正博、宮田卓樹、平田宏聡
- Organizer
  第45回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-21H05127
[Presentation] Intercellular force dictating proliferative abilities of epidermal cells2022
- Author(s)
  Hiroaki Hirata
- Organizer
  9th World Congress of Biomechanics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K12596
[Presentation] Intercellular force dictating proliferative abilities of epidermal cells2022
- Author(s)
  Hiroaki Hirata
- Organizer
  9th World Congress of Biomechanics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05127
[Presentation] 表皮細胞単層中での細胞周期進行と細胞運動の協調制御：細胞間接着とRac1の役割2021
- Author(s)
  平田宏聡、Oleg Dobrokhotov、曽我部正博
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-21H05127
[Presentation] 表皮細胞単層中での細胞周期進行と細胞運動の協調制御：細胞間接着とRac1の役割2021
- Author(s)
  平田宏聡、Oleg Dobrokhotov、曽我部正博
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K12596
[Presentation] 細胞内の力の伝達経路としてストレスファイバーに必要な機械的性質2021
- Author(s)
  勝田紘基、長山和亮、清島大資、町山裕亮、曽我部正博、宮田卓樹、平田宏聡
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-21H05127
[Presentation] 表皮細胞増殖の接触阻害における細胞間引張力の役割と表皮がんでの破綻2021
- Author(s)
  平田宏聡、Oleg Dobrokhotov、砂川真輝、榎本篤、曽我部正博
- Organizer
  第5回日本メカノバイオロジー学会
- Data Source
  KAKENHI-PROJECT-20K12596
[Presentation] Tension at adherens junction inhibits proliferation and promotes differentiation of keratinocyte carcinoma cells2020
- Author(s)
  Oleg Dobrokhotov、曽我部正博、平田宏聡
- Organizer
  日本生物物理学会第58回年会
- Data Source
  KAKENHI-PROJECT-20K12596
[Presentation] Molecular and biophysical bases for modulation of the focal adhesion-actin cytoskeleton system in response to extracellular substrate rigidity2020
- Author(s)
  平田宏聡
- Organizer
  第53回生物機械システム研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K23748
[Presentation] 角化細胞の増殖の接触阻害には接着結合の引張力が必須である2020
- Author(s)
  平田宏聡、Oleg Dobrokhotov、曽我部正博
- Organizer
  日本生物物理学会第58回年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K12596
[Presentation] 角化細胞の増殖の接触阻害には接着結合の引張力が必須である2020
- Author(s)
  平田宏聡、Oleg Dobrokhotov、曽我部正博
- Organizer
  日本生物物理学会第58回年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K23748
[Presentation] 細胞外基質硬度による焦点接着斑―アクチン骨格系調節の分子・生物物理基盤2020
- Author(s)
  平田宏聡
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K12596
[Presentation] 細胞外基質硬度による焦点接着斑―アクチン骨格系調節の分子・生物物理基盤2020
- Author(s)
  平田宏聡
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K23748
[Presentation] Molecular and biophysical bases for modulation of the focal adhesion-actin cytoskeleton system in response to extracellular substrate rigidity2020
- Author(s)
  平田宏聡
- Organizer
  第53回生物機械システム研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K12596
[Presentation] RhoA activation induces cell cycle exit and differentiation of skin cancer cells2019
- Author(s)
  Oleg Dobrokhotov、Masahiro Sokabe、Hiroaki Hirata
- Organizer
  日本生物物理学会第57回年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K23748

1. Nonomura Keiko (70799246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 森松賢順 (70580934)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 中澤直高 (90800780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 出口真次 (30379713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 榎本篤 (20432255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKAJIMA Wataru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 加藤昌志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 田中恵子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIRATA Hiroaki 平田 宏聡

Hirata Hiroaki 平田 宏聡

Research Projects

Research Products

Co-Researchers

The mechanical interaction paradox between cancer cell aggregates and 3D extracellular matrix and its effect on aggregate growthPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Promotion of Pressio-Neuroscience

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Compressive stress against brain tumors: its effect on tumor cell growth and the underlying molecular mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Tissue deformation-dependent regulation of cell proliferation: distinct roles of cell-substrate and cell-cell adhesionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism for coordination of cell motility and proliferation in epithelial cells: role of intercellular mechanical interactionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] Material-based Mechanobiology, CHAPTER 4 Measurement and Manipulation of Cellular Forces Using Silicone Elastomers2022

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Editorial: Multicellularity: Views from cellular signaling and mechanics2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell mechanosensing underlies homeostasis of multicellular systems2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Tension-dependent Generation of Biochemical Signals on Actomyosin Fibers2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] MMP24 as a Target of YAP Is a Potential Prognostic Factor in Cancer Patients2020

Author(s)

Journal Title

DOI

HIRATA Hiroaki 平田宏聡

Hirata Hiroaki 平田宏聡