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HIRATA Hiroaki  平田 宏聡

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Hirata Hiroaki  平田 宏聡

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Researcher Number 90414028
Other IDs
Affiliation (Current) 2025: 金沢工業大学, バイオ・化学部, 教授
Affiliation (based on the past Project Information) *help 2025: 金沢工業大学, バイオ・化学部, 教授
2021 – 2023: 金沢工業大学, バイオ・化学部, 教授
2019 – 2021: 名古屋大学, 医学系研究科, 特任講師
Review Section/Research Field
Principal Investigator
Basic Section 90110:Biomedical engineering-related / Transformative Research Areas, Section (III) / 0702:Biology at cellular to organismal levels, and related fields
Except Principal Investigator
Transformative Research Areas, Section (III)
Keywords
Principal Investigator
アドヘレンスジャンクション / メカノバイオロジー / 細胞増殖 / 圧縮刺激 / グリオーマ / 力学刺激 / 力学相互作用 / スフェロイド / 三次元培養 / 腫瘍細胞塊 … More / 上皮細胞 / 組織伸展 / アクトミオシンファイバー / FAK / 焦点接着斑 / Rac1 / 葉状仮足 / 細胞協同現象 … More
Except Principal Investigator
研究会 / 冠ワークショップ / 研究者ネットワーク / 領域会議 / 冠シンポジウム / 総括班 / 脳神経科学 / メカノセンシング Less
  • Research Projects

    (5 results)
  • Research Products

    (32 results)
  • Co-Researchers

    (6 People)
  •  がん細胞塊と3次元細胞外基質との力学相互作用パラドックスと細胞塊成長への効果Principal Investigator

    • Principal Investigator
      平田 宏聡
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 90110:Biomedical engineering-related
    • Research Institution
      Kanazawa Institute of Technology
  •  Promotion of Pressio-Neuroscience

    • Principal Investigator
      Nonomura Keiko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Tokyo Institute of Technology
      National Institute for Basic Biology
  •  Compressive stress against brain tumors: its effect on tumor cell growth and the underlying molecular mechanismPrincipal Investigator

    • Principal Investigator
      Hirata Hiroaki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Kanazawa Institute of Technology
  •  Tissue deformation-dependent regulation of cell proliferation: distinct roles of cell-substrate and cell-cell adhesionsPrincipal Investigator

    • Principal Investigator
      Hiroaki Hirata
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 90110:Biomedical engineering-related
    • Research Institution
      Kanazawa Institute of Technology
      Nagoya University
  •  Mechanism for coordination of cell motility and proliferation in epithelial cells: role of intercellular mechanical interactionPrincipal Investigator

    • Principal Investigator
      Hirata Hiroaki
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0702:Biology at cellular to organismal levels, and related fields
    • Research Institution
      Nagoya University

All 2023 2022 2021 2020 2019

All Journal Article Presentation Book

  • [Book] Material-based Mechanobiology, CHAPTER 4 Measurement and Manipulation of Cellular Forces Using Silicone Elastomers2022

    • Author(s)
      Hiroaki Hirata, Masahiro Sokabe
    • Total Pages
      21
    • Publisher
      The Royal Society of Chemistry
    • Data Source
      KAKENHI-PLANNED-21H05127
  • [Journal Article] Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments2023

    • Author(s)
      Torii Takeru、Sugimoto Wataru、Itoh Katsuhiko、Kinoshita Natsuki、Gessho Masaya、Goto Toshiyuki、Uehara Ikuno、Nakajima Wataru、Budirahardja Yemima、Miyoshi Daisuke、Nishikata Takahito、Tanaka Nobuyuki、Hirata Hiroaki、Kawauchi Keiko
    • Journal Title

      Cell Death & Disease

      Volume: 14 Issue: 11 Pages: 766-766

    • DOI

      10.1038/s41419-023-06310-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K08293, KAKENHI-PLANNED-21H05127, KAKENHI-PROJECT-21H02062
  • [Journal Article] Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers2023

    • Author(s)
      Katsuta Hiroki、Okuda Satoru、Nagayama Kazuaki、Machiyama Hiroaki、Kidoaki Satoru、Kato Masashi、Sokabe Masahiro、Miyata Takaki、Hirata Hiroaki
    • Journal Title

      iScience

      Volume: 26 Issue: 3 Pages: 106090-106090

    • DOI

      10.1016/j.isci.2023.106090

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17KT0033, KAKENHI-PROJECT-21K18326, KAKENHI-PROJECT-22K19890, KAKENHI-PROJECT-22KK0145, KAKENHI-PLANNED-21H05127, KAKENHI-PROJECT-21H02656, KAKENHI-PROJECT-21H03804, KAKENHI-PROJECT-20K12596, KAKENHI-PROJECT-19H01147, KAKENHI-PUBLICLY-21H00363, KAKENHI-PLANNED-22H05170, KAKENHI-PROJECT-19H05627
  • [Journal Article] Editorial: Multicellularity: Views from cellular signaling and mechanics2023

    • Author(s)
      Hirata Hiroaki、Nakazawa Naotaka、Hirashima Tsuyoshi、Ravasio Andrea
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 11 Pages: 1-3

    • DOI

      10.3389/fcell.2023.1172921

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-21H05126, KAKENHI-PLANNED-21H05127, KAKENHI-PROJECT-20K12596, KAKENHI-PROJECT-18K14819
  • [Journal Article] Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells2021

    • Author(s)
      Dobrokhotov Oleg、Sunagawa Masaki、Torii Takeru、Mii Shinji、Kawauchi Keiko、Enomoto Atsushi、Sokabe Masahiro、Hirata Hiroaki
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 9 Pages: 728383-728383

    • DOI

      10.3389/fcell.2021.728383

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K12596, KAKENHI-PLANNED-21H05127
  • [Journal Article] Cell mechanosensing underlies homeostasis of multicellular systems2020

    • Author(s)
      Nonomura Keiko、Hirata Hiroaki
    • Journal Title

      Biophysics and Physicobiology

      Volume: 17 Issue: 0 Pages: 100-102

    • DOI

      10.2142/biophysico.BSJ-2020019

    • NAID

      130007919803

    • ISSN
      2189-4779
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K12596, KAKENHI-PROJECT-19K23748
  • [Journal Article] Tension-dependent Generation of Biochemical Signals on Actomyosin Fibers2020

    • Author(s)
      Hiroaki Hirata、Masahiro Sokabe
    • Journal Title

      Seibutsu Butsuri

      Volume: 60 Issue: 2 Pages: 089-093

    • DOI

      10.2142/biophys.60.089

    • NAID

      130007818289

    • ISSN
      0582-4052, 1347-4219
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K23748
  • [Journal Article] MMP24 as a Target of YAP Is a Potential Prognostic Factor in Cancer Patients2020

    • Author(s)
      Wataru Sugimoto、Katsuhiko Itoh、Hiroaki Hirata、Yoshinori Abe、Takeru Torii、Yasumasa Mitsui、Yemima Budirahardja、Nobuyuki Tanaka、Keiko Kawauchi
    • Journal Title

      Bioengineering

      Volume: 7 Issue: 1 Pages: 18-18

    • DOI

      10.3390/bioengineering7010018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K23748, KAKENHI-PROJECT-17H04054, KAKENHI-PROJECT-19J21096, KAKENHI-PROJECT-18K06231
  • [Journal Article] 細胞増殖の接触阻害における物理的因子の役割2020

    • Author(s)
      平田宏聡、Oleg Dobrokhotov、曽我部正博
    • Journal Title

      実験医学

      Volume: 38 Pages: 93-99

    • Data Source
      KAKENHI-PROJECT-19K23748
  • [Journal Article] Coordination between Cell Motility and Cell Cycle Progression in Keratinocyte Sheets via Cell-Cell Adhesion and Rac12020

    • Author(s)
      Hirata Hiroaki、Dobrokhotov Oleg、Sokabe Masahiro
    • Journal Title

      iScience

      Volume: 23 Issue: 11 Pages: 101729-101729

    • DOI

      10.1016/j.isci.2020.101729

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K12596, KAKENHI-PROJECT-19K23748
  • [Presentation] PIEZO1-mediated mechanosensation controls multiple events during brain development2023

    • Author(s)
      Keiko Nonomura, Mayumi Okamoto, Naotaka Nakazawa, Hiroaki Hirata
    • Organizer
      第46回日本分子生物学会年会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-21H05124
  • [Presentation] PIEZO1メカノセンサーチャネルの脳発生における役割の解析2023

    • Author(s)
      野々村恵子、岡本麻友美、平田宏聡、中澤直高
    • Organizer
      第46回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-21H05127
  • [Presentation] alpha-アクチニンはストレスファイバーのメカニクスを変化させることで収縮力の伝達を調節している2023

    • Author(s)
      勝田紘基、奥田覚、長山和亮、町山裕亮、木戸秋悟、宮田卓樹、曽我部正博、平田宏聡
    • Organizer
      第46回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-21H05127
  • [Presentation] alpha-アクチニンによって調節されるストレスファイバーの物性はミオシン由来の力の伝達効率を調節する2023

    • Author(s)
      勝田紘基、奥田覚、長山和亮、町山裕亮、加藤昌志、曽我部正博、宮田卓樹、木戸秋悟、平田宏聡
    • Organizer
      日本生物物理学会第61回年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-21H05127
  • [Presentation] Distinct roles of cell-cell and cell-ECM adhesions in mechanical regulation of epidermal cancer cell proliferation2023

    • Author(s)
      平田宏聡、Oleg Dobrokhotov、曽我部正博
    • Organizer
      日本生物物理学会第61回年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-21H05127
  • [Presentation] 細胞接着境界の力学状態による表皮がん細胞の増殖制御2023

    • Author(s)
      平田宏聡
    • Organizer
      第46回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-21H05127
  • [Presentation] 張力繊維に沿った力の伝達効率はa-アクチニンの架橋によって変化する機械的特性に依存している2022

    • Author(s)
      勝田紘基、奥田覚、長山和亮、町山裕亮、木戸秋悟、加藤昌志、曽我部正博、宮田卓樹、平田宏聡
    • Organizer
      第45回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K12596
  • [Presentation] 張力繊維に沿った力の伝達効率はa-アクチニンの架橋によって変化する機械的特性に依存している2022

    • Author(s)
      勝田紘基、奥田覚、長山和亮、町山裕亮、木戸秋悟、加藤昌志、曽我部正博、宮田卓樹、平田宏聡
    • Organizer
      第45回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-21H05127
  • [Presentation] Intercellular force dictating proliferative abilities of epidermal cells2022

    • Author(s)
      Hiroaki Hirata
    • Organizer
      9th World Congress of Biomechanics
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K12596
  • [Presentation] Intercellular force dictating proliferative abilities of epidermal cells2022

    • Author(s)
      Hiroaki Hirata
    • Organizer
      9th World Congress of Biomechanics
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-21H05127
  • [Presentation] 表皮細胞単層中での細胞周期進行と細胞運動の協調制御:細胞間接着とRac1の役割2021

    • Author(s)
      平田宏聡、Oleg Dobrokhotov、曽我部正博
    • Organizer
      第44回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-21H05127
  • [Presentation] 表皮細胞単層中での細胞周期進行と細胞運動の協調制御:細胞間接着とRac1の役割2021

    • Author(s)
      平田宏聡、Oleg Dobrokhotov、曽我部正博
    • Organizer
      第44回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K12596
  • [Presentation] 細胞内の力の伝達経路としてストレスファイバーに必要な機械的性質2021

    • Author(s)
      勝田紘基、長山和亮、清島大資、町山裕亮、曽我部正博、宮田卓樹、平田宏聡
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PLANNED-21H05127
  • [Presentation] 表皮細胞増殖の接触阻害における細胞間引張力の役割と表皮がんでの破綻2021

    • Author(s)
      平田宏聡、Oleg Dobrokhotov、砂川真輝、榎本篤、曽我部正博
    • Organizer
      第5回日本メカノバイオロジー学会
    • Data Source
      KAKENHI-PROJECT-20K12596
  • [Presentation] Tension at adherens junction inhibits proliferation and promotes differentiation of keratinocyte carcinoma cells2020

    • Author(s)
      Oleg Dobrokhotov、曽我部正博、平田宏聡
    • Organizer
      日本生物物理学会第58回年会
    • Data Source
      KAKENHI-PROJECT-20K12596
  • [Presentation] Molecular and biophysical bases for modulation of the focal adhesion-actin cytoskeleton system in response to extracellular substrate rigidity2020

    • Author(s)
      平田宏聡
    • Organizer
      第53回生物機械システム研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K23748
  • [Presentation] 角化細胞の増殖の接触阻害には接着結合の引張力が必須である2020

    • Author(s)
      平田宏聡、Oleg Dobrokhotov、曽我部正博
    • Organizer
      日本生物物理学会第58回年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K12596
  • [Presentation] 角化細胞の増殖の接触阻害には接着結合の引張力が必須である2020

    • Author(s)
      平田宏聡、Oleg Dobrokhotov、曽我部正博
    • Organizer
      日本生物物理学会第58回年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K23748
  • [Presentation] 細胞外基質硬度による焦点接着斑―アクチン骨格系調節の分子・生物物理基盤2020

    • Author(s)
      平田宏聡
    • Organizer
      第43回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K12596
  • [Presentation] 細胞外基質硬度による焦点接着斑―アクチン骨格系調節の分子・生物物理基盤2020

    • Author(s)
      平田宏聡
    • Organizer
      第43回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K23748
  • [Presentation] Molecular and biophysical bases for modulation of the focal adhesion-actin cytoskeleton system in response to extracellular substrate rigidity2020

    • Author(s)
      平田宏聡
    • Organizer
      第53回生物機械システム研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K12596
  • [Presentation] RhoA activation induces cell cycle exit and differentiation of skin cancer cells2019

    • Author(s)
      Oleg Dobrokhotov、Masahiro Sokabe、Hiroaki Hirata
    • Organizer
      日本生物物理学会第57回年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K23748
  • 1.  Nonomura Keiko (70799246)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  森松 賢順 (70580934)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  中澤 直高 (90800780)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  NAKAJIMA Wataru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  加藤 昌志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  田中 恵子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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