Kikuchi Masafumi 菊地正史

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Masafumi Kikuchi 菊地正史

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Researcher Number	90420025
Other IDs
Affiliation (Current)	2025: 秋田大学, 医学部附属病院, 教授
Affiliation (based on the past Project Information) *help	2023: 秋田大学, 医学部附属病院, 教授 2021 – 2022: 東北大学, 薬学研究科, 准教授
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator 個別化医療 / Modeling & Simulation / PK/PD / 分子標的抗がん薬 / がんクリニカルシーケンス

Research Projects
(1 results)
Research Products
(22 results)

Establishment of personalized therapy with molecularly targeted anticancer drugs based on next-generation sequencing and PK/PD modelsPrincipal Investigator
- Principal Investigator
  
  Masafumi Kikuchi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Akita University
  Tohoku University

All 2023 2022 2021

All Journal Article Presentation Book

[Book] 今日の臨床検査2023-20242023
- Author(s)
  矢冨裕、山田俊幸、下澤達雄、佐藤健夫、松井啓隆、長尾美紀、眞野成康、菊地正史
- Total Pages
  620
- Publisher
  南江堂
- ISBN
  9784524233199
- Data Source
  KAKENHI-PROJECT-21K06708
[Book] 今日の臨床検査2021-20222021
- Author(s)
  櫻林郁之介、矢冨　裕、廣畑俊成、山田俊幸、石黒厚至、眞野成康、菊地正史
- Total Pages
  768
- Publisher
  南江堂
- ISBN
  9784524228034
- Data Source
  KAKENHI-PROJECT-21K06708
[Journal Article] The prevalence of end-of-life chemotherapy and targeted therapy in Japan, assessed using a health claims database2023
- Author(s)
  Tsuchiya M, Obara T, Kikuchi M, Mano N
- Journal Title
  
  Cancer Chemotherapy and Pharmacology
  
  Volume: 91 Issue: 6 Pages: 501-506
- DOI
  10.1007/s00280-023-04535-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06708
[Journal Article] High throughput LC/ESI-MS/MS method for simultaneous analysis of 20 oral molecular-targeted anticancer drugs and the active metabolite of sunitinib in human plasma2023
- Author(s)
  Hirasawa T, Kikuchi M, Takasaki S, Kumondai K, Sato Y, Sato, Imoto E, Hayakawa Y, Maekawa M, Mano N
- Journal Title
  
  Heliyon
  
  Volume: 9 Issue: 6 Pages: e16926-e16926
- DOI
  10.1016/j.heliyon.2023.e16926
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06708
[Journal Article] Therapeutic Drug Monitoring of Blood Sirolimus and Tacrolimus Concentrations for Polypharmacy Management in a Lymphangioleiomyomatosis Patient Taking Two Cytochrome P450 3A Inhibitors2023
- Author(s)
  Kumondai Masaki、Kikuchi Masafumi、Mizuguchi Atsushi、Hayashi Nagomi、Ui Masahiro、Hirama Takashi、Okada Yoshinori、Sato Yu、Sato Toshihiro、Maekawa Masamitsu、Mano Nariyasu
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 260 Issue: 1 Pages: 29-34
- DOI
  10.1620/tjem.2023.J016
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08509, KAKENHI-PROJECT-21K06708, KAKENHI-PROJECT-22K15333
[Journal Article] Development of a Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analytical Method for Urinary Endogenous Substrates and Metabolites for Predicting Cytochrome P450 3A4 Activity2023
- Author(s)
  Masaki Kumondai, Masamitsu Maekawa, Eiji Hishinuma, Yu Sato, Toshihiro Sato, Masafumi Kikuchi, Masahiro Hiratsuka, Nariyasu Mano
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 3 Pages: 455-463
- DOI
  10.1248/bpb.b22-00840
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-03-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06708, KAKENHI-PROJECT-22K15333
[Journal Article] Evaluation of a capillary microsampling device for analyzing plasma lenvatinib concentration in patients with hepatocellular carcinoma2022
- Author(s)
  Akihiro Saito, Masafumi Kikuchi, Yuko Matsumoto, Erina Sugawara, Gesshu Takao, Hayato Inomata, Akane Takahashi, Yuji Sato, Masaki Kumondai, Yu Sato, Toshihiro Sato, Masashi Ninomiya, Jun Inoue, Masamitsu Maekawa, Nariyasu Mano
- Journal Title
  
  Therapeutic Drug Monitoring
  
  Volume: 44 Issue: 6 Pages: 771-776
- DOI
  10.1097/ftd.0000000000001013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06708
[Journal Article] Shifting the linear range of the calibration curves for the quantification of oral molecular-targeted anticancer drugs and the active metabolite in human plasma using LC-ESI-MS/MS2022
- Author(s)
  Tensei Hirasawa, Masafumi Kikuchi, Shinya Takasaki, Masaki Kumondai, Yu Sato, Toshihiro Sato, Eishi Imoto, Yoshihiro Hayakawa, Masamitsu Maekawa, Nariyasu Mano
- Journal Title
  
  Medical Mass Spectrometry
  
  Volume: 6 Issue: 1 Pages: 52-63
- DOI
  10.24508/mms.2022.06.006
- ISSN
  2432-7441, 2432-745X
- Year and Date
  2022-06-25
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06708
[Journal Article] High‐throughput liquid chromatography/electrospray ionization?tandem mass spectrometry method using in‐source collision‐induced dissociation for simultaneous quantification of imatinib, dasatinib, bosutinib, nilotinib, and ibrutinib in human plasma2021
- Author(s)
  Hirasawa Tensei、Kikuchi Masafumi、Shigeta Kensuke、Takasaki Shinya、Sato Yu、Sato Toshihiro、Ogura Jiro、Onodera Koichi、Fukuhara Noriko、Onishi Yasushi、Maekawa Masamitsu、Mano Nariyasu
- Journal Title
  
  Biomedical Chromatography
  
  Volume: 35 Issue: 8
- DOI
  10.1002/bmc.5124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06708
[Presentation] Microsampling WingTMを用いたヒト血漿中レンバチニブ濃度定量法の開発2023
- Author(s)
  菊地正史、眞野成康
- Organizer
  第55回日本臨床検査医学会東北支部総会・第34回日本臨床化学会東北支部総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06708
[Presentation] がんゲノム医療におけるがん遺伝子パネル検査の基礎知識2023
- Author(s)
  菊地正史、眞野成康
- Organizer
  日本臨床腫瘍薬学会学術大会2023
- Invited
- Data Source
  KAKENHI-PROJECT-21K06708
[Presentation] LC-MS/MSを用いた血中薬物濃度のハイスループット定量法の開発と臨床実装2023
- Author(s)
  菊地正史、眞野成康
- Organizer
  第33回日本医療薬学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06708
[Presentation] マイクロサンプリングデバイスを用いたヒト血漿中レンバチニブ濃度定量法の開発2023
- Author(s)
  菊地正史、齊藤明博、佐藤祐司、公文代將希、佐藤裕、佐藤紀宏、二宮匡史、井上淳、前川正充、眞野成康
- Organizer
  医療薬学フォーラム2023
- Data Source
  KAKENHI-PROJECT-21K06708
[Presentation] シクロスポリンおよびダナゾールとの併用により、血中ベネトクラクス濃度が高値を示した急性骨髄性白血病の1例2023
- Author(s)
  植木悠悟、菊地正史、公文代將希、大槻彩夏、石川大雅、福田朱理、小林大典、佐藤祐司、前川正充、眞野成康
- Organizer
  日本病院薬剤師会東北ブロック第12回学術大会
- Data Source
  KAKENHI-PROJECT-21K06708
[Presentation] 肺移植患者における複数のCYP3A阻害薬とシロリムスおよびタクロリムスの相互作用を考慮した投与量設計2023
- Author(s)
  公文代將希、菊地正史、水口敦史、林和未、宇井雅博、平間崇、岡田克典、佐藤裕、佐藤紀宏、前川正充、眞野成康
- Organizer
  日本病院薬剤師会東北ブロック第12回学術大会
- Data Source
  KAKENHI-PROJECT-21K06708
[Presentation] LC-MS/MSを用いる向精神薬一斉分析法の構築に向けた基礎的検討2023
- Author(s)
  前川正充、佐藤紀宏、佐藤裕、公文代將希、菊地正史、眞野成康
- Organizer
  第55回日本臨床検査医学会東北支部総会・第34回日本臨床化学会東北支部総会
- Data Source
  KAKENHI-PROJECT-21K06708
[Presentation] 血中薬物濃度測定におけるLC-MS/MSの活用と精度管理2023
- Author(s)
  菊地正史、佐藤祐司、前川正充、眞野成康
- Organizer
  第63回日本臨床化学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06708
[Presentation] LC/ESI-MS/MSを用いた経口分子標的抗がん薬及び代謝物の一斉定量法の開発2022
- Author(s)
  菊地正史、平澤天晴、髙﨑新也、公文代將希、佐藤裕、佐藤紀宏、前川正充、眞野成康
- Organizer
  第32回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-21K06708
[Presentation] レンバチニブによる破壊性甲状腺炎を発現した肝細胞癌の2例2022
- Author(s)
  菅原英里奈、菊地正史、鷹尾月舟、松本侑子、齊藤明博、公文代將希、佐藤裕、二宮匡史、井上淳、眞野成康
- Organizer
  日本医療薬学会第5回フレッシャーズ・カンファランス
- Data Source
  KAKENHI-PROJECT-21K06708
[Presentation] 進行腎癌に対するニボルマブ＋イピリムマブ併用療法の初回投与後に劇症1型糖尿病を発症した一例2022
- Author(s)
  朝倉聡美、今野壮太、高橋麻由子、堀川美帆、菊地正史、眞野成康
- Organizer
  日本病院薬剤師会東北ブロック第11回学術大会
- Data Source
  KAKENHI-PROJECT-21K06708
[Presentation] LC/ESI-MS/MSを用いた経口分子標的抗がん薬及び代謝物の一斉定量条件の検討2021
- Author(s)
  平澤天晴、菊地正史、髙﨑新也、公文代將希、佐藤裕、佐藤紀宏、前川正充、眞野成康
- Organizer
  第46回日本医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-21K06708
[Presentation] LC-MS/MSを用いた血中薬物濃度測定における精度管理2021
- Author(s)
  菊地正史、髙﨑新也、前川正充、眞野成康
- Organizer
  第37回日本TDM学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06708

Kikuchi Masafumi 菊地 正史

Masafumi Kikuchi 菊地 正史

Research Projects

Research Products

Establishment of personalized therapy with molecularly targeted anticancer drugs based on next-generation sequencing and PK/PD modelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 今日の臨床検査2023-20242023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 今日の臨床検査2021-20222021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] The prevalence of end-of-life chemotherapy and targeted therapy in Japan, assessed using a health claims database2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High throughput LC/ESI-MS/MS method for simultaneous analysis of 20 oral molecular-targeted anticancer drugs and the active metabolite of sunitinib in human plasma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Therapeutic Drug Monitoring of Blood Sirolimus and Tacrolimus Concentrations for Polypharmacy Management in a Lymphangioleiomyomatosis Patient Taking Two Cytochrome P450 3A Inhibitors2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Development of a Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analytical Method for Urinary Endogenous Substrates and Metabolites for Predicting Cytochrome P450 3A4 Activity2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Evaluation of a capillary microsampling device for analyzing plasma lenvatinib concentration in patients with hepatocellular carcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Shifting the linear range of the calibration curves for the quantification of oral molecular-targeted anticancer drugs and the active metabolite in human plasma using LC-ESI-MS/MS2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] High‐throughput liquid chromatography/electrospray ionization?tandem mass spectrometry method using in‐source collision‐induced dissociation for simultaneous quantification of imatinib, dasatinib, bosutinib, nilotinib, and ibrutinib in human plasma2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Microsampling WingTMを用いたヒト血漿中レンバチニブ濃度定量法の開発2023

Author(s)

Organizer

Data Source

[Presentation] がんゲノム医療におけるがん遺伝子パネル検査の基礎知識2023

Author(s)

Organizer

Data Source

[Presentation] LC-MS/MSを用いた血中薬物濃度のハイスループット定量法の開発と臨床実装2023

Author(s)

Organizer

Data Source

[Presentation] マイクロサンプリングデバイスを用いたヒト血漿中レンバチニブ濃度定量法の開発2023

Author(s)

Organizer

Kikuchi Masafumi 菊地正史

Masafumi Kikuchi 菊地正史