Watanabe Hideki 渡邊秀樹

… Alternative Names

渡邊秀樹ワタナベヒデキ

WATANABE Hideki 渡邊秀樹

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Researcher Number	90422089
Affiliation (Current)	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長 2021 – 2022: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長 2020: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 2018: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 2016: 産業技術総合研究所, バイオメディカル研究部門, 主任研究員 2010 – 2011: 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 研究員
Review Section/Research Field	Principal Investigator Basic Section 27040:Biofunction and bioprocess engineering-related / Biofunction/Bioprocess Except Principal Investigator Basic Section 37010:Bio-related chemistry / Biomolecular chemistry
Keywords	Principal Investigator バイオセンサー / 人工タンパク質 / 進化分子工学 / 品質分析 / 抗体医薬品 / ファージディスプレイ / 抗体医薬 / 分子進化工学 / 人工蛋白質 / 生物機能工学 … More Except Principal Investigator … More RiPPs / 環化機構 / ペプチド環化機構 / DUF3328タンパク質 / リボソームペプチド / 環化因子 / 糸状菌 / 両親媒性 / シクロファン構造 / 環状ペプチド / ヒト血清アルブミン / 血中安定性 / 薬物動態 / タンパク質工学 / バイオ医薬品 / バイオテクノロジー / 分子設計 Less

抗体の高次構造変化を高精度・網羅的に描出する小型人工タンパク群の合理設計Principal Investigator
- Principal Investigator
  
  渡邊秀樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
抗体医薬品の立体構造品質を特異的に識別する人工タンパク質プローブの分析原理Principal Investigator
- Principal Investigator
  
  渡邊秀樹
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Cyclization mechanism of fungal amphipathic ribosomal peptides
- Principal Investigator
  
  Umemura Maiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Quality control monitoring of therapeutic antibodies on the basis of artificial proteins specific for the higher-order structure of antibody domainsPrincipal Investigator
- Principal Investigator
  
  Watanabe Hideki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Design of Humanized Adaptor Proteins Exhibiting Albumin-Binding Affinity
- Principal Investigator
  
  Honda Shinya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  National Institute of Advanced Industrial Science and Technology
A buildup approach to the design of a small-sized protein via an autonomously-folded short segmentPrincipal Investigator
- Principal Investigator
  
  WATANABE Hideki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  National Institute of Advanced Industrial Science and Technology

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2011 2010

All Journal Article Presentation Book Patent

[Book] タンパク質のアモルファス凝集と溶解性―基礎研究からバイオ産業・創薬研究への応用まで―2019
- Author(s)
  今村　比呂志、渡邊　秀樹、千賀　由佳子、本田　真也
- Total Pages
  15
- Publisher
  シーエムシー出版
- ISBN
  9784781313979
- Data Source
  KAKENHI-PROJECT-18K04860
[Journal Article] Interspecies Genomic Variation and Transcriptional Activeness of Secondary Metabolism-Related Genes in Aspergillus Section Fumigati2021
- Author(s)
  Takahashi Hiroki、Umemura Maiko、Ninomiya Akihiro、Kusuya Yoko、Shimizu Masaaki、Urayama Syun-ichi、Watanabe Akira、Kamei Katsuhiko、Yaguchi Takashi、Hagiwara Daisuke
- Journal Title
  
  Frontiers in Fungal Biology
  
  Volume: 2 Pages: 656751-656751
- DOI
  10.3389/ffunb.2021.656751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05720, KAKENHI-PROJECT-16H06279
[Journal Article] バイオ医薬品の分析のコツ品質評価のための基礎と応用（第１２回バイオ医薬品に含まれる不純物）2018
- Author(s)
  本田　真也、千賀　由佳子、今村　比呂志、野田　尚宏、宮房　孝光、渡邊　秀樹
- Journal Title
  
  ファームテクジャパン
  
  Volume: 34 Pages: 1865-1877
- Data Source
  KAKENHI-PROJECT-18K04860
[Journal Article] Biosensing Probe for Quality Control Monitoring of the Structural Integrity of Therapeutic Antibodies2016
- Author(s)
  Watanabe H, Yageta S, Imamura H, Honda S
- Journal Title
  
  Analytical Chemistry
  
  Volume: 88 Issue: 20 Pages: 10095-10101
- DOI
  10.1021/acs.analchem.6b02526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350968
[Journal Article] Adaptive assembly: maximizing the potential of a given functional peptide with a tailor-made protein scaffold2015
- Author(s)
  Watanabe H, Honda S
- Journal Title
  
  CHEMISTRY & BIOLOGY
  
  Volume: 22 Issue: 9 Pages: 1165-1173
- DOI
  10.1016/j.chembiol.2015.07.015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26350968
[Journal Article] Structure of the artificial protein AF.p17 developed by adaptive assembly2015
- Author(s)
  Watanabe H, Honda S
- Journal Title
  
  Photon Factory Activity Report 2014 Part B
  
  Volume: 32 Pages: 227-227
- Data Source
  KAKENHI-PROJECT-26350968
[Journal Article] Engineered protein A ligands, derived from a histidine-scanning library, facilitate the affinity purification of IgG under mild acidic conditions.2014
- Author(s)
  Tsukamoto, M., Watanabe, H., Ooishi, A., Honda, S.
- Journal Title
  
  J Biol Eng.
  
  Volume: 8 Issue: 1
- DOI
  10.1186/1754-1611-8-15
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26350968
[Journal Article] Tracing primordial protein evolution through structurally guided stepwise segment elongation2014
- Author(s)
  Hideki Watanabe, Kazuhiko Yamasaki, Shinya Honda
- Journal Title
  
  J. Biol. Chem
  
  Volume: vol. 289 Issue: 6 Pages: 3394-3404
- DOI
  10.1074/jbc.m113.530592
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22760617, KAKENHI-PROJECT-23510273, KAKENHI-PROJECT-26350968
[Journal Article] Structure-based histidine substitution for optimizing pH-sensitive Staphylococcus protein A2013
- Author(s)
  Hideki Watanabe, Hiroyuki Matsumaru, Ayako Ooishi, Shinya Honda
- Journal Title
  
  J. Chromatogr. B
  
  Volume: vol. 929 Pages: 155-160
- DOI
  10.1016/j.jchromb.2013.04.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22760617, KAKENHI-PROJECT-23510273
[Journal Article] ～抗体医療研究の技術を工業材料開発へ～抗体分子の「ナノ糊(のり)としての利用」2011
- Author(s)
  渡邊秀樹、梅津光央、熊谷泉
- Journal Title
  
  MATERIAL STAGE
  
  Volume: 10-10 Pages: 6-9
- Data Source
  KAKENHI-PROJECT-22760617
[Journal Article] Biomimetic engineering of modular bispecific antibodies for biomolecule immobilization2011
- Author(s)
  Hideki Watanabe
- Journal Title
  
  Langmuir
  
  Volume: 27 Issue: 16 Pages: 9656-966
- DOI
  10.1021/la2006259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22226013, KAKENHI-PROJECT-22760617
[Journal Article] ～抗体医療研究の技術を工業材料開発へ～抗体分子の「ナノ糊(のり)としての利用2011
- Author(s)
  渡邊秀樹, 梅津光央, 熊谷泉
- Journal Title
  
  Material Stage
  
  Volume: vol. 10 Pages: 6-9
- Data Source
  KAKENHI-PROJECT-22760617
[Journal Article] 分子デザインによる抗体精製用蛋白質プロテインGの安定性およびpH応答性の論理的改変2010
- Author(s)
  渡邊秀樹、本田真也
- Journal Title
  
  BIO INDUSTRY
  
  Volume: 27-12 Pages: 72-78
- Data Source
  KAKENHI-PROJECT-22760617
[Journal Article] 分子デザインによる抗体精製用蛋白質プロテインGの安定性およびpH応答性の論理的改変2010
- Author(s)
  渡邊秀樹, 本田真也
- Journal Title
  
  BIO INDUSTRY
  
  Volume: vol. 27 Pages: 72-78
- Data Source
  KAKENHI-PROJECT-22760617
[Patent] 微小タンパク質の骨格構造に基づく分子ライブラリ2013
- Inventor(s)
  本田真也, 渡邊秀樹, 山崎和彦
- Industrial Property Rights Holder
  独立行政法人産業技術総合研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2013-12-09
- Overseas
- Data Source
  KAKENHI-PROJECT-22760617
[Patent] 抗体結合性ペプチド2013
- Inventor(s)
  渡邊秀樹, 本田真也
- Industrial Property Rights Holder
  独立行政法人産業技術総合研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2013-12-25
- Overseas
- Data Source
  KAKENHI-PROJECT-22760617
[Presentation] Variation of Kex2-processed repeat proteins (KEPs) and asci/sclerotia formation in eight fungal strains at the MMRC fungal resources2023
- Author(s)
  Maiko Umemura, Daisuke Hagiwara, Takahito Toyotome, Takashi Yaguchi, Akira Watanabe, and Katsuhiko Kamei
- Organizer
  The 9th Global Network Forum on Infection and Immunity
- Data Source
  KAKENHI-PROJECT-20K05720
[Presentation] 小型人工タンパク質プローブを基盤とした抗体医薬品の高次構造品質管理技術2022
- Author(s)
  渡邊秀樹、宮房孝光、本田真也
- Organizer
  第１回日本抗体学会学術大会
- Data Source
  KAKENHI-PROJECT-21K04803
[Presentation] 小型人工タンパク質のバイオ医薬品産業応用2020
- Author(s)
  渡邊秀樹
- Organizer
  BioJapan2020
- Data Source
  KAKENHI-PROJECT-18K04860
[Presentation] Biosensing for quality control monitoring of the structural integrity of therapeutic antibodies2019
- Author(s)
  渡邊　秀樹、八桁　清樹、今村　比呂志、本田　真也
- Organizer
  PepTalk: The Protein Science Week 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K04860
[Presentation] 抗体の高次構造変性を認識する人工タンパク質の創出と抗体品質分析技術への展開2018
- Author(s)
  渡邊　秀樹、本田　真也
- Organizer
  第39回動物細胞工学シンポジウム「バイオ医薬品の高品質化に向けた物性解析」
- Invited
- Data Source
  KAKENHI-PROJECT-18K04860
[Presentation] 人工タンパク質プローブによる抗体医薬品のドメイン特異的高次構造劣化モニタリング2018
- Author(s)
  渡邊　秀樹、林田　菜生子、本田　真也
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K04860
[Presentation] 抗体の非天然型構造に特異的な小型人工タンパク質を用いたバイオアッセイ法の確立2017
- Author(s)
  千賀由佳子、宮房孝光、渡邊秀樹、本田真也
- Organizer
  第16回産総研・産技連LS-BT合同研究発表会
- Place of Presentation
  産業技術総合研究所（つくば）
- Year and Date
  2017-01-31
- Data Source
  KAKENHI-PROJECT-26350968
[Presentation] 抗体の非天然型構造検出に有用なアッセイ法の考案2016
- Author(s)
  千賀由佳子、宮房孝光、渡邊秀樹、本田真也
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-26350968
[Presentation] 穏和な条件下で抗体精製を可能にするリガンドタンパク質の設計2015
- Author(s)
  塚本雅之、大石郁子、渡邊秀樹、本田真也
- Organizer
  第67回日本生物工学会大会
- Place of Presentation
  城山観光ホテル（鹿児島）
- Year and Date
  2015-10-27
- Data Source
  KAKENHI-PROJECT-26350968
[Presentation] 進化分子工学による構造と機能の共創出2015
- Author(s)
  本田真也、渡邊秀樹
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島）
- Year and Date
  2015-06-26
- Invited
- Data Source
  KAKENHI-PROJECT-26350968
[Presentation] Generating a small-sized protein from a functional peptide2014
- Author(s)
  Watanabe H, Honda S.
- Organizer
  第52回日本生物物理学会年会
- Place of Presentation
  札幌コンベンションセンター（札幌）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26350968
[Presentation] 機能性ペプチドから組み上げる小型人工タンパク質創出2014
- Author(s)
  渡邊秀樹、本田真也
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜（横浜）
- Year and Date
  2014-06-25
- Data Source
  KAKENHI-PROJECT-26350968

1. Honda Shinya (50344122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. Umemura Maiko (00552259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. OSHIRO Satoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Watanabe Hideki 渡邊 秀樹

渡邊 秀樹 ワタナベ ヒデキ

WATANABE Hideki 渡邊 秀樹

Research Projects

Research Products

Co-Researchers

抗体の高次構造変化を高精度・網羅的に描出する小型人工タンパク群の合理設計Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

抗体医薬品の立体構造品質を特異的に識別する人工タンパク質プローブの分析原理Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cyclization mechanism of fungal amphipathic ribosomal peptides

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Quality control monitoring of therapeutic antibodies on the basis of artificial proteins specific for the higher-order structure of antibody domainsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Design of Humanized Adaptor Proteins Exhibiting Albumin-Binding Affinity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A buildup approach to the design of a small-sized protein via an autonomously-folded short segmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] タンパク質のアモルファス凝集と溶解性―基礎研究からバイオ産業・創薬研究への応用まで―2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Interspecies Genomic Variation and Transcriptional Activeness of Secondary Metabolism-Related Genes in Aspergillus Section Fumigati2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] バイオ医薬品の分析のコツ 品質評価のための基礎と応用（第１２回 バイオ医薬品に含まれる不純物）2018

Author(s)

Journal Title

Data Source

[Journal Article] Biosensing Probe for Quality Control Monitoring of the Structural Integrity of Therapeutic Antibodies2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adaptive assembly: maximizing the potential of a given functional peptide with a tailor-made protein scaffold2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of the artificial protein AF.p17 developed by adaptive assembly2015

Author(s)

Journal Title

Data Source

[Journal Article] Engineered protein A ligands, derived from a histidine-scanning library, facilitate the affinity purification of IgG under mild acidic conditions.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tracing primordial protein evolution through structurally guided stepwise segment elongation2014

Author(s)

Journal Title

DOI

Watanabe Hideki 渡邊秀樹

渡邊秀樹ワタナベヒデキ

WATANABE Hideki 渡邊秀樹

[Journal Article] バイオ医薬品の分析のコツ品質評価のための基礎と応用（第１２回バイオ医薬品に含まれる不純物）2018

[Journal Article] ～抗体医療研究の技術を工業材料開発へ～抗体分子の「ナノ糊(のり)としての利用2011

[Presentation] 小型人工タンパク質プローブを基盤とした抗体医薬品の高次構造品質管理技術2022