YAMAGUCHI Keiichi 山口圭一

Researcher Number	90432187
External Links
Affiliation (Current)	2025: 大阪大学, 大学院工学研究科, 特任准教授(常勤)
Affiliation (based on the past Project Information) *help	2023 – 2024: 大阪大学, 大学院工学研究科, 特任准教授(常勤) 2022: 大阪大学, 大学院工学研究科, 特任講師 2022: 大阪大学, 大学院工学研究科, 特任講師(常勤) 2020 – 2021: 大阪大学, 国際医工情報センター, 寄附研究部門助教 2020 – 2021: 大阪大学, 蛋白質研究所, 特任助教(常勤) … More 2009: 岐阜大学, 人獣感染防御研究センター, 助教 2006 – 2008: 岐阜大学, 人獣感染防御研究センター, 学術研究補佐員 2007: 岐阜大 Less
Review Section/Research Field	Principal Investigator Basic Section 43040:Biophysics-related / Drug development chemistry / Structural biochemistry Except Principal Investigator Basic Section 53040:Nephrology-related / Basic Section 43040:Biophysics-related / Biophysics / Biological Sciences
Keywords	Principal Investigator アミロイド線維 / プリオン / 狂牛病 / 液液相分離 / 蛋白質凝集 / コスモトロープ / 塩析 / 塩析作用 / 酸 / 液-液相分離 … More / ポリリン酸 / ATP / アニオン / 塩 / 検出試薬 … More Except Principal Investigator 慢性腎臓病 / 脳神経変性疾患 / 凝集 / フォールディング / 相転移 / 変性 / 溶解度 / 過飽和 / アミロイド線維 / 蛋白質凝集 / 老化 / 生体分子 / 蛋白質 / β2-ミクログロブリン / アミロイドーシス / アルブミン / 敗血症 / 感染症 / インドキシル硫酸 / 血小板 / マクロファージ / 血液透析 / ポリリン酸 / 能変性疾患 / 脳神経疾患 / 生物物理 / リゾチーム / 巻き戻り / 圧力 / プリオン病 / 神経変性疾患 / 生物物理学 / 構造変換 / ダイナミクス / 立体構造 / in vivo NMR / 異常立体構造変換反応 / 遅い構造揺らぎ / ポリスレオニン / スクレイピー型 / 細胞内立体構造 / プリオン Less

ウレミックトキシンによるアルブミン機能異常の解析と恒常性を回復する治療法の開発
- Principal Investigator
  
  山本卓
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
Exploring the supersaturation-dependent protein science
- Principal Investigator
  
  後藤祐児
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Osaka University
Mechanism of protein aggregation induced by polyphosphate analogues with multivalent chargesPrincipal Investigator
- Principal Investigator
  
  山口圭一
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Osaka University
Polyphosphate: A Novel Marker of Phosphorus Metabolism and its Association with Infection in Kidney Disease
- Principal Investigator
  
  Yamamoto Suguru
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
Development of controlling technology for protein dissociation and aggregation using high pressure.
- Principal Investigator
  
  KAMATARI Yujio
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Gifu University
細胞内プリオンタンパク質の立体構造、ダイナミクス、及び立体構造変換反応の解明
- Principal Investigator
  
  桑田一夫
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
Search of a low molecular compound selectively binding to amyloid fibrils of prion and the elucidation of its binding mechanismPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Keiichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu University
異常プリオン発生メカニズムの解明Principal Investigator
- Principal Investigator
  
  山口圭一
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Structural biochemistry
- Research Institution
  Gifu University

All 2024 2023 2022 2021 2020 2011 2010 2009 2008 2007

All Journal Article Presentation Book

[Book] 月刊細胞2021
- Author(s)
  山口圭一, 中島吉太郎, 後藤祐児
- Total Pages
  4
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-20K06580
[Book] 超音波TECHNO2021
- Author(s)
  中島吉太郎, 山口圭一, 荻博次, 後藤祐児
- Total Pages
  5
- Publisher
  日本工業出版
- Data Source
  KAKENHI-PROJECT-20K06580
[Journal Article] Surface Modification of Ultrasonic Cavitation by Surfactants Improves Detection Sensitivity of α-Synuclein Amyloid Seeds2024
- Author(s)
  Nakajima Kichitaro、Ota Tomoki、Toda Hajime、Yamaguchi Keiichi、Goto Yuji、Ogi Hirotsugu
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 15 Issue: 8 Pages: 1643-1651
- DOI
  10.1021/acschemneuro.4c00071
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K14013, KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-23K23848
[Journal Article] Supersaturation, a Critical Factor Underlying Proteostasis of Amyloid Fibril Formation2024
- Author(s)
  Goto Yuji、Nakajima Kichitaro、Yamamoto Suguru、Yamaguchi Keiichi
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: - Issue: 14 Pages: 168475-168475
- DOI
  10.1016/j.jmb.2024.168475
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K14013, KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-20K08628, KAKENHI-PROJECT-23K23848
[Journal Article] Mass spectrometry-based proteomic analysis of proteins adsorbed by hexadecyl-immobilized cellulose bead column for the treatment of dialysis-related amyloidosis2024
- Author(s)
  Yamamoto Suguru、Yamamoto Keiko、Hirao Yoshitoshi、Yamaguchi Keiichi、Nakajima Kichitaro、Sato Mami、Kawachi Miho、Domon Mio、Goto Kei、Omori Kentaro、Iino Noriaki、Shimada Hisaki、Aoyagi Ryuzi、Ei Isei、Goto Shin、Goto Yuji、Gejyo Fumitake、Yamamoto Tadashi、Narita Ichiei
- Journal Title
  
  Amyloid
  
  Volume: - Issue: 2 Pages: 1-11
- DOI
  10.1080/13506129.2024.2315148
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K14013, KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-20K08628, KAKENHI-PROJECT-23K23848
[Journal Article] Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor2023
- Author(s)
  Zhou Lianjie、Hajiri Touko、Nakajima Kichitaro、Aguirre Cesar、Ikenaka Kensuke、Mochizuki Hideki、Yamaguchi Keiichi、Goto Yuji、Ogi Hirotsugu
- Journal Title
  
  ACS Sensors
  
  Volume: 8 Issue: 7 Pages: 2598-2608
- DOI
  10.1021/acssensors.3c00331
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K14013, KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-23K23848, KAKENHI-PROJECT-23K24212
[Journal Article] Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism2023
- Author(s)
  Choong Chi-Jing、Aguirre Cesar、Kakuda Keita、Beck Goichi、Nakanishi Hiroki、Kimura Yasuyoshi、Shimma Shuichi、Nabekura Kei、Hideshima Makoto、Doi Junko、Yamaguchi Keiichi、et al.
- Journal Title
  
  Acta Neuropathologica
  
  Volume: 145 Issue: 5 Pages: 573-595
- DOI
  10.1007/s00401-023-02555-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-20K06910, KAKENHI-PROJECT-23K24212, KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-22K15709, KAKENHI-PROJECT-22K07516, KAKENHI-PROJECT-22K07538, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-23K23848
[Journal Article] Mechanisms of polyphosphate-induced amyloid fibril formation triggered by breakdown of supersaturation2023
- Author(s)
  Yamaguchi Keiichi、Nakajima Kichitaro、Goto Yuji
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 20 Issue: 1 Pages: n/a
- DOI
  10.2142/biophysico.bppb-v20.0013
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-21K19224, KAKENHI-PROJECT-23K23848
[Journal Article] Research on risk factors on the onset of dialysis-related amyloidosis and strategy for prevention of amyloidosis2023
- Author(s)
  中島吉太郎、山口圭一、後藤祐児
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 33 Issue: 4 Pages: 193-198
- DOI
  10.14894/medchem.33.4_193
- ISSN
  2432-8618, 2432-8626
- Year and Date
  2023-11-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-20K06580
[Journal Article] Ultrasonic Induction of Amyloid Fibril Formation and Its Application2023
- Author(s)
  NAKAJIMA Kichitaro、YAMAGUCHI Keiichi、OGI Hirotsugu、GOTO Yuji
- Journal Title
  
  The Review of High Pressure Science and Technology
  
  Volume: 33 Issue: 2 Pages: 107-115
- DOI
  10.4131/jshpreview.33.107
- ISSN
  0917-639X, 1348-1940
- Year and Date
  2023-06-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-20K06580
[Journal Article] Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson’s disease2022
- Author(s)
  Hideshima Makoto、Kimura Yasuyoshi、Aguirre Cesar、Kakuda Keita、Takeuchi Toshihide、Choong Chi-Jing、Doi Junko、Nabekura Kei、Yamaguchi Keiichi、Nakajima Kichitaro、Baba Kousuke、Nagano Seiichi、Goto Yuji、Nagai Yoshitaka、Mochizuki Hideki、Ikenaka Kensuke
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 351-351
- DOI
  10.1038/s41598-021-04131-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17034, KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-21H02841
[Journal Article] Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis2022
- Author(s)
  Nakajima Kichitaro、Yamaguchi Keiichi、Noji Masahiro、Aguirre Cesar、Ikenaka Kensuke、Mochizuki Hideki、Zhou Lianjie、Ogi Hirotsugu、Ito Toru、Narita Ichiei、Gejyo Fumitake、Naiki Hironobu、Yamamoto Suguru、Goto Yuji
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 5689-5689
- DOI
  10.1038/s41467-022-33247-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-20K08628, KAKENHI-PROJECT-21K06967, KAKENHI-PROJECT-22K14013, KAKENHI-PROJECT-19H03674, KAKENHI-PROJECT-21K19224, KAKENHI-PROJECT-23K23848
[Journal Article] Supersaturation-Dependent Formation of Amyloid Fibrils2022
- Author(s)
  Goto Yuji、Noji Masahiro、Nakajima Kichitaro、Yamaguchi Keiichi
- Journal Title
  
  Molecules
  
  Volume: 27 Issue: 14 Pages: 4588-4588
- DOI
  10.3390/molecules27144588
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-21K19224, KAKENHI-PROJECT-23K23848
[Journal Article] Acceleration of amyloid fibril formation by multichannel sonochemical reactor2022
- Author(s)
  Noi Kentaro、Nakajima Kichitaro、Yamaguchi Keiichi、So Masatomo、Ikenaka Kensuke、Mochizuki Hideki、Goto Yuji、Ogi Hirotsugu
- Journal Title
  
  Japanese Journal of Applied Physics
  
  Volume: 61 Issue: SG Pages: SG1002-SG1002
- DOI
  10.35848/1347-4065/ac4142
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06580
[Journal Article] Development of HANABI, an ultrasonication-forced amyloid fibril inducer2022
- Author(s)
  Goto Yuji、Nakajima Kichitaro、Yamaguchi Keiichi、So Masatomo、Ikenaka Kensuke、Mochizuki Hideki、Ogi Hirotsugu
- Journal Title
  
  Neurochemistry International
  
  Volume: 153 Pages: 105270-105270
- DOI
  10.1016/j.neuint.2021.105270
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-20K06580
[Journal Article] The residual structure of acid‐denatured β2‐microglobulin is relevant to an ordered fibril morphology2022
- Author(s)
  Tomiyama Ryosuke、So Masatomo、Yamaguchi Keiichi、Miyanoiri Yohei、Sakurai Kazumasa
- Journal Title
  
  Protein Science
  
  Volume: 32 Issue: 1
- DOI
  10.1002/pro.4487
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-22K06106
[Journal Article] Strong acids induce amyloid fibril formation of β2-microglobulin via an anion-binding mechanism2021
- Author(s)
  Yamaguchi Keiichi、Hasuo Kenshiro、So Masatomo、Ikenaka Kensuke、Mochizuki Hideki、Goto Yuji
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 297 Issue: 5 Pages: 101286-101286
- DOI
  10.1016/j.jbc.2021.101286
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-20K06580
[Journal Article] pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro2021
- Author(s)
  Yamamoto Suguru、Sasahara Kenichi、Domon Mio、Yamaguchi Keiichi、Ito Toru、Goto Shin、Goto Yuji、Narita Ichiei
- Journal Title
  
  Toxins
  
  Volume: 13 Issue: 2 Pages: 116-116
- DOI
  10.3390/toxins13020116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-19H03674, KAKENHI-PROJECT-20K08628
[Journal Article] Pathogenic D76N Variant of β2-Microglobulin: Synergy of Diverse Effects in Both the Native and Amyloid States2021
- Author(s)
  Bulyaki Eva、Kun Judit、Molnar Tamas、Papp Alexandra、Micsonai Andras、Vadaszi Henrietta、Marialigeti Borbala、Kovacs Attila Istvan、Gellen Gabriella、Yamaguchi Keiichi、Lin Yuxi、So Masatomo、Jozsi Mihaly、Schlosser Gitta、Lee Young-Ho、Liliom Karoly、Goto Yuji、Kardos Jozsef
- Journal Title
  
  Biology
  
  Volume: 10 Issue: 11 Pages: 1197-1197
- DOI
  10.3390/biology10111197
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-20K06580
[Journal Article] Half-Time Heat Map Reveals Ultrasonic Effects on Morphology and Kinetics of Amyloidogenic Aggregation Reaction2021
- Author(s)
  Nakajima Kichitaro、Toda Hajime、Yamaguchi Keiichi、So Masatomo、Ikenaka Kensuke、Mochizuki Hideki、Goto Yuji、Ogi Hirotsugu
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 12 Issue: 18 Pages: 3456-3466
- DOI
  10.1021/acschemneuro.1c00461
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22484, KAKENHI-PROJECT-20K06580
[Journal Article] Aberrant mucosal immunoreaction to tonsillar microbiota in immunoglobulin A nephropathy2021
- Author(s)
  Hiroki Yamaguchi, Shin Goto, Nao Takahashi, Masafumi Tsuchida, Hirofumi Watanabe, Suguru Yamamoto, Yoshikatsu Kaneko, Koichi Higashi, Hiroshi Mori, Yukio Nakamura, Arata Horii, Ken Kurokawa, Ichiei Narita
- Journal Title
  
  Nephrol Dial Transplant.
  
  Volume: ３６ Issue: 1 Pages: 75-86
- DOI
  10.1093/ndt/gfaa223
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09372, KAKENHI-PROJECT-20K08628, KAKENHI-PROJECT-18K08234, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19H03674
[Journal Article] Polyphosphates induce amyloid fibril formation of α-synuclein in concentration-dependent distinct manners2021
- Author(s)
  Yamaguchi Keiichi、So Masatomo、Aguirre Cesar、Ikenaka Kensuke、Mochizuki Hideki、Kawata Yasushi、Goto Yuji
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100510-100510
- DOI
  10.1016/j.jbc.2021.100510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-18H02741
[Journal Article] Inorganic polyphosphate potentiates lipopolysaccharide-induced macrophage inflammatory response2020
- Author(s)
  Ito Toru、Yamamoto Suguru、Yamaguchi Keiichi、Sato Mami、Kaneko Yoshikatsu、Goto Shin、Goto Yuji、Narita Ichiei
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 12 Pages: 4014-4023
- DOI
  10.1074/jbc.ra119.011763
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-20K08628
[Journal Article] Critical region for amyloid fibril formation of mouse prion protein : Unusual amyloidogenic properties of the helix 2 peptide2008
- Author(s)
  Kei-ichi Yamaguchi
- Journal Title
  
  Biochemistry 47
  
  Pages: 13242-13251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790091
[Journal Article] Critical region for amyloid fibril formation of mouse prion protein: unusual amyloidogenic properties of the helix2 peptide2008
- Author(s)
  Kei-ichi Yamaguchi, Tomoharu Matsumoto, Kazuo Kuwata
- Journal Title
  
  Biochemistry 47巻
  
  Pages: 13242-13251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790091
[Journal Article] Critical Region for Amyloid Fibril Formaition of Mouse Prion Protein : Unusual Amyloidogenic Properties of Helix 2 Peptide2008
- Author(s)
  Kei-ichi Yamaguchi, et.al.
- Journal Title
  
  Biochemistry 47
  
  Pages: 13242-13251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059016
[Journal Article] プリオン病の発症と伝播機構2007
- Author(s)
  山口圭一
- Journal Title
  
  細胞工学 26巻・2号
  
  Pages: 151-155
- Data Source
  KAKENHI-PROJECT-18870008
[Presentation] αシヌクレインのATP依存的なアミロイド線維形成機構2023
- Author(s)
  山口圭一, 中島吉太郎, 後藤祐児
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] 液-液相分離によるαシヌクレインのアミロイド線維形成促進2023
- Author(s)
  山口圭一, 三間穣治，作田浩輝，中島吉太郎, 吉川研一，後藤祐児
- Organizer
  第10回日本アミロイドーシス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] Mechanisms of polyphosphate-induced amyloid formation2023
- Author(s)
  Keiichi Yamaguchi
- Organizer
  Amyloid Symposium Munich 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] 強酸が促進するβ 2 ミクログロブリンのアミロイド線維形成2022
- Author(s)
  山口圭一、蓮尾健史郎、宗正智、池中建介、望月秀樹、後藤祐児
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] Mass spectrometry-based proteomic analysis of adsorbed molecules associated with dialysis-related amyloidosis in hexadecyl-immobilized cellulose beads2022
- Author(s)
  Yamamoto S, Yamamoto K, Hirao Y, Yamamoto T, Yamaguchi K, Nakajima K, Goto Y, Goto S, Gejyo F, Narita I
- Organizer
  XVIII. International Symposium on Amyloidosis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08628
[Presentation] Mechanisms of polyphosphate-induced amyloid formation under ultrasonication2022
- Author(s)
  Keiichi Yamaguchi、Kichitaro Nakajima、Yuji Goto
- Organizer
  Proteostasis and Disease Symposium 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] ATPに依存した蛋白質凝集機構の解明2022
- Author(s)
  山口圭一、澤田眞弥、中島吉太郎、後藤祐児
- Organizer
  第9回日本アミロイドーシス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] Specific effect of ultrasonic irradiation on amyloid-fibril formation reaction2021
- Author(s)
  中島吉太郎, 戸田元, 山口圭一, 荻博次, 後藤祐児
- Organizer
  第42回超音波シンポジウムUSE2021
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] アミロイド凝集反応におけるダイナミクスと凝集形態に及ぼす超音波キャビテーション効果について2021
- Author(s)
  戸田元, 中島吉太郎, 山口圭一, 荻博次, 後藤祐児
- Organizer
  第59回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] Analysis of Heparin-Induced Tau Oligomer Formation by Dynamic Light Scattering2021
- Author(s)
  Ayumi Masui, Keisuke Yuzu, Keiichi Yamaguchi, Yuji Goto, Yasushi Kawata, Eri Chatani
- Organizer
  第59回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] 同時多検体超音波照射システムを用いた加速的アミロイド線維形成反応の研究2021
- Author(s)
  中島吉太郎, 戸田元, 山口圭一, 宗正智, 荻博次, 後藤祐児
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] 超音波照射下におけるαシヌクレインのATP依存的アミロイド形成2021
- Author(s)
  山口圭一, 澤田眞弥, 中島吉太郎, 宗正智, 荻博次, 河田康志, 後藤祐児
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] 超音波照射を利用した夾雑物存在下におけるβ2ミクログロブリンのアミロイド線維形成反応の研究2021
- Author(s)
  中島吉太郎, 山口圭一, 山本卓, 荻博次, 後藤祐児
- Organizer
  第59回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] pHによるウレミックトキシンの蛋白結合能の変化2021
- Author(s)
  山本卓, 山口圭一, 土門美緒, 伊藤徹, 後藤眞, 後藤祐児, 成田一衛
- Organizer
  第64回日本腎臓学会学術総会.
- Data Source
  KAKENHI-PROJECT-20K08628
[Presentation] 動的光散乱法によるタウのオリゴマー形成機構の解析2021
- Author(s)
  益井歩未, 柚佳祐, 山口圭一, 後藤祐児, 河田康志, 茶谷絵理
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] 超音波照射下におけるATP依存的なαシヌクレインのアミロイド線維形成2021
- Author(s)
  山口圭一, 澤田眞弥, 中島吉太郎, 後藤祐児
- Organizer
  第8回日本アミロイドーシス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro:2020
- Author(s)
  Suguru Yamamoto, Kenichi Sasahara, Mio Domon, Keiichi Yamaguchi, Toru Ito, Shin Goto, Yuji Goto, and Ichiei Narita
- Organizer
  Kidney Week 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08628
[Presentation] せん断応力場によるアミロイドβペプチドの凝集加速効果の動特性研究2020
- Author(s)
  福田靖丈、野井健太郎、宗正智、中島吉太郎、山口圭一、後藤祐児、荻博次
- Organizer
  第41回超音波シンポジウムUSE2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] Amyloid Formation And Breakdown Of Supersaturation2020
- Author(s)
  Masahiro Noji、Keiichi Yamaguchi、Eri Chatani、Yuji Goto
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] 超音波照射による凝集加速反応を利用したβ2m蛋白質の高感度なシード検出2020
- Author(s)
  松田良太、押鐘寧、野井健太郎、宗正智、中島吉太郎、山口圭一、後藤祐児、荻博次
- Organizer
  第41回超音波シンポジウムUSE2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] Mechanism of polyphosphate-induced amyloid fibrillization of α-synuclein2020
- Author(s)
  Keiichi Yamaguchi、Masatomo So、Kenji Sasahara、Yasushi Kawata、Yuji Goto
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] 無線水晶振動子マイクロバランスによるβ2m凝集過程における粘弾性と構造変化の観察2020
- Author(s)
  羽尻瞳子、周連杰、中島吉太郎、宗正智、山口圭一、後藤祐児、荻博次
- Organizer
  第41回超音波シンポジウムUSE2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] 超音波照射下におけるATP依存的αシヌクレインのアミロイド線維形成2020
- Author(s)
  山口圭一、澤田眞弥、中島吉太郎、宗正智、荻博次、後藤祐児
- Organizer
  第41回超音波シンポジウムUSE2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] 極微量アミロイド線維シードの加速的増幅のためのハイスループット超音波化学反応装置2020
- Author(s)
  中島吉太郎、戸田元、山口圭一、宗正智、荻博次、後藤祐児
- Organizer
  第41回超音波シンポジウムUSE2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06580
[Presentation] Low-lying excited state of prion protein directly linked to pathogenic conversion2011
- Author(s)
  Y. O. Kamatari, K. Yamaguchi, & K. Kuwata
- Organizer
  The International Symposium on Nuclear Magnetic Resonance 2011
- Place of Presentation
  横浜
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21570163
[Presentation] プリオンタンパク質への結合様式による抗プリオン化合物の分類と作用機構の解明2010
- Author(s)
  鎌足雄司,早野陽介,山口圭一,武藤(細川)淳二,桑田一夫
- Organizer
  第49回NMR討論会
- Place of Presentation
  東京
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-21570163
[Presentation] プリオン病におけるタクロリムスの治療効果2009
- Author(s)
  中垣岳大,佐藤克也,鎌足雄司,新竜一郎,石橋大輔,山口尚宏,西田教行
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  東京
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-21570163
[Presentation] プリオンタンパク質構造変換におけるホットスポットと抗プリオン化合物2009
- Author(s)
  鎌足雄司,早野陽介,木村力,武藤淳二,石倉孝一,山本典史,山口圭一,桑田一夫
- Organizer
  第48回NMR討論会
- Place of Presentation
  福岡
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-21570163
[Presentation] 無細胞蛋白質合成系を用いたデュアルピンポイント蛍光標識プリオン蛋白質の合成2009
- Author(s)
  武藤淳二,山口圭一,鎌足雄司,桑田一夫
- Organizer
  第4回無細胞生命科学研究会
- Place of Presentation
  岐阜
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-21570163
[Presentation] シーディングによる2種類のプリオンアミロイド線維の伝播2009
- Author(s)
  山口圭一、松本友治、武藤淳二、桑田一夫
- Organizer
  日本生物物理学会第47回年会
- Place of Presentation
  アスティとくしま
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] アンバーおよび4塩基コドンを用いたデュアルピンポイント蛍光標識プリオン蛋白質の合成2009
- Author(s)
  武藤(細川)淳二,山口圭一,鎌足雄司,桑田一夫
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  東京
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-21570163
[Presentation] Development of double-fluorescent-labeled prion protein system for FRET analysis2009
- Author(s)
  J. Muto, K.-I. Yamaguchi, Y. O. Kamatari, K. Kuwata
- Organizer
  VIII European Symposium of The Protein Society
- Place of Presentation
  Zurich, Switzerland
- Year and Date
  2009-06-16
- Data Source
  KAKENHI-PROJECT-21570163
[Presentation] プリオン病におけるタクロリムスの治療効果2009
- Author(s)
  中垣岳大、佐藤克也、鎌足雄司、新竜一郎、石橋大輔、山口尚宏、西田教行
- Organizer
  第57回日本ウイルス学会
- Place of Presentation
  都市センターホテル
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] Rational design of anti-prion compounds targeting the PrP characteristic sites.2009
- Author(s)
  Kazuo Kuwata, Tsutomu Kimura, Yuji O.Kamatari, Junji Hosokawa-Muto, Keiichi Yamaguchi, Takeshi Ishikawa, Takakazu Ishikura, Norifumi Yamamoto, Yumiko Okuda.
- Organizer
  Prion2009
- Place of Presentation
  Thessaloniki-Chalkidiki Greece
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] アンバーおよび4塩基コドンを用いたデュアルピンポイント蛍光標識プリオン蛋白質の合成2009
- Author(s)
  武藤淳二、山口圭一、鎌足雄司、桑田一夫
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  都市センターホテル
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] Development of double-fluorescent-labeled prion protein system for FRET analysis.2009
- Author(s)
  武藤淳二、山口圭一、鎌足雄司、桑田一夫
- Organizer
  V III European Symposium of The Protein Society
- Place of Presentation
  Zurich Switzerland
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] シーディングによるマウスPrP アミロイド線維の伝播2008
- Author(s)
  山口圭一
- Organizer
  第46回日本生物物理学会年会
- Place of Presentation
  福岡国際会議場(福岡県)
- Data Source
  KAKENHI-PROJECT-19790091
[Presentation] シーディングによるマウスPrPアミロイド線維の伝播2008
- Author(s)
  山口圭一
- Organizer
  第46回日本生物物理学会年会
- Place of Presentation
  福岡国際会議場(福岡)
- Data Source
  KAKENHI-PROJECT-19790091
[Presentation] 部分ペプチドを用いたプリオンのアミロイド線維形成部位の系統的スクリーニング2008
- Author(s)
  山口圭一
- Organizer
  第72回日本生化学会中部支部例会・シンポジウム
- Place of Presentation
  岐阜大学医学部記念会館
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] 部分ペプチドを用いたマウスプリオン蛋白質のアミロイド線維形成部位の研究2008
- Author(s)
  山口圭一
- Organizer
  第8回日本蛋白質科学会年会
- Place of Presentation
  タワーホール船堀(東京都江戸川区)
- Data Source
  KAKENHI-PROJECT-19790091
[Presentation] 部分ペプチドを用いたプリオンのアミロイド線維形成部位の系統的スクリーニング2008
- Author(s)
  山口圭一
- Organizer
  第72 回日本生化学会中部支部例会
- Place of Presentation
  岐阜大学医学部記念会館(岐阜県)
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-19790091
[Presentation] 部分ペプチドを用いたプリオンのアミロイド線維形成部位の系統的スクリーニング2008
- Author(s)
  山口圭一
- Organizer
  第72回日本生化学会中部支部例会
- Place of Presentation
  岐阜大学医学部記念会館(岐阜)
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-19790091
[Presentation] シーディングによるマウスPrPアミロイド線維の伝播2008
- Author(s)
  山口圭一
- Organizer
  第46回日本生物物理学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] 部分ペプチドを用いたマウスプリオン蛋白質のアミロイド線維形成部位の研究2008
- Author(s)
  山口圭一
- Organizer
  第8 回日本蛋白質科学会年会
- Place of Presentation
  タワーホール船堀(東京都江戸川区)
- Data Source
  KAKENHI-PROJECT-19790091
[Presentation] マウスプリオン蛋白質のアミロイド原性ペプチドに関する研究2007
- Author(s)
  山口圭一
- Organizer
  第45回日本生物物理学会年会
- Place of Presentation
  パシフイコ横浜(神奈川県)
- Year and Date
  2007-12-23
- Data Source
  KAKENHI-PROJECT-19790091
[Presentation] マウスプリオン蛋白質のアミロイド原性ペプチドに関する研究2007
- Author(s)
  山口圭一
- Organizer
  第45 回日本生物物理学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Data Source
  KAKENHI-PROJECT-19790091

1. Yamamoto Suguru (70444156)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. 後藤祐児 (40153770)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. MUTO Junji (80432186)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. KAMATARI Yujio (70342772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. 桑田一夫 (00170142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 成田一衛 (20272817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 田中崇裕 (70455400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 北村信隆 (90224972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 渡邊博志 (70398220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 角田渓太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 中島吉太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
12. 堀井新

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 高橋奈央

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAGUCHI Keiichi 山口 圭一

Research Projects

Research Products

Co-Researchers

ウレミックトキシンによるアルブミン機能異常の解析と恒常性を回復する治療法の開発

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Exploring the supersaturation-dependent protein science

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Mechanism of protein aggregation induced by polyphosphate analogues with multivalent chargesPrincipal Investigator

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Polyphosphate: A Novel Marker of Phosphorus Metabolism and its Association with Infection in Kidney Disease

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Development of controlling technology for protein dissociation and aggregation using high pressure.

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細胞内プリオンタンパク質の立体構造、ダイナミクス、及び立体構造変換反応の解明

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Search of a low molecular compound selectively binding to amyloid fibrils of prion and the elucidation of its binding mechanismPrincipal Investigator

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異常プリオン発生メカニズムの解明Principal Investigator

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[Book] 月刊細胞2021

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[Book] 超音波TECHNO2021

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[Journal Article] Surface Modification of Ultrasonic Cavitation by Surfactants Improves Detection Sensitivity of α-Synuclein Amyloid Seeds2024

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[Journal Article] Supersaturation, a Critical Factor Underlying Proteostasis of Amyloid Fibril Formation2024

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[Journal Article] Mass spectrometry-based proteomic analysis of proteins adsorbed by hexadecyl-immobilized cellulose bead column for the treatment of dialysis-related amyloidosis2024

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[Journal Article] Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor2023

Author(s)

Journal Title

YAMAGUCHI Keiichi 山口圭一