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Hiroyuki Tanaka  田中 弘之

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TANAKA Hiroyuki  田中 弘之

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Researcher Number 90433060
Other IDs
Affiliation (based on the past Project Information) *help 2021 – 2022: 宮崎大学, 医学部, 助教
2017 – 2019: 宮崎大学, 医学部, 助教
2009 – 2014: University of Miyazaki, 医学部, 助教
Review Section/Research Field
Principal Investigator
Human pathology / Basic Section 49020:Human pathology-related
Except Principal Investigator
Experimental pathology
Keywords
Principal Investigator
肺癌 / HAI-1 / 膜蛋白質 / LRP11 / 膜型セリンプロテアーゼ / 病理学 / 膜結合型セリンプロテアーゼインヒビター / セリンプロテアーゼインヒビター / プロテアーゼインヒビター / HGF … More / LDLR-related protein 11 / HGF 肝細胞増殖因子 / serine protease / HGF activator inhibitor / HAI-1 : HGF activator inhibitor type-1 / LRP11:Low density lipoprotein receptor-related protein 11 / HAI-1:HGF activator inhibitor type-1 / HGF:Hepatocyte growth factor / LRP11 : Low density lipoprotein receptor-related protein 11 / HGF activator inhibitor type-1 / HGF : Hepatocyte growth factor … More
Except Principal Investigator
macrophage-stimulating protein / matriptase / HGF activator / 上皮形態形成 / 膜型プロテアーゼ / 膜型プロテアーゼインヒビター / conditional knockout / 上皮細胞 / HAI-1 / プロテアーゼ / 分子 Less
  • Research Projects

    (5 results)
  • Research Products

    (44 results)
  • Co-Researchers

    (4 People)
  •  肺癌における膜型セリンプロテアーゼとそのインヒビターの機能解析Principal Investigator

    • Principal Investigator
      田中 弘之
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      University of Miyazaki
  •  Functional analysis of membrane-type serine protease inhibitor in invasion and metastasis of lung cancerPrincipal Investigator

    • Principal Investigator
      Hiroyuki Tanaka
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      University of Miyazaki
  •  The role of membrane-type serine protease inhibitors in invasion/metastasis of lung cancerPrincipal Investigator

    • Principal Investigator
      TANAKA Hiroyuki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      University of Miyazaki
  •  Role of expression of HAI-1 and LRP11 in Lung CnacerPrincipal Investigator

    • Principal Investigator
      TANAKA Hiroyuki
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      University of Miyazaki
  •  Regulation of proteolysis on epithelial cell membrane and its implication in the epithelial disorders

    • Principal Investigator
      KATAOKA Hiroaki
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      University of Miyazaki

All 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

  • [Journal Article] Cutaneous paragonimiasis due to triploid Paragonimus westermani presenting as a non-migratory subcutaneous nodule: a case report.2014

    • Author(s)
      Kodama M, Akaki M, Tanaka H, Maruyama H, Nagayasu E, Yokouchi T, Arimura Y, Kataoka H
    • Journal Title

      J Med Case Rep.

      Volume: 8 Issue: 1 Pages: 1-5

    • DOI

      10.1186/1752-1947-8-346

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24590419
  • [Journal Article] Hepatocyte growth factor activator inhibitor type 1 is a suppressor of intestinal tumorigenesis.2013

    • Author(s)
      Hoshiko S, Kawaguchi M, Fukushima T, Haruyama Y, Yorita K, Tanaka H, Seiki M, Inatsu H, Kitamura K, Kataoka H.
    • Journal Title

      Cancer Res.

      Volume: 73(8) Issue: 8 Pages: 2659-70

    • DOI

      10.1158/0008-5472.can-12-3337

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-24390099, KAKENHI-PROJECT-24590419, KAKENHI-PROJECT-24590486
  • [Journal Article] Antitumor effect of dehydroxymethylepoxyquinomicin (DHMEQ), a small molecule inhibitor of nuclear factor-κB, on glioblastoma2012

    • Author(s)
      Fukushima T, Kawaguchi M, Yorita K, Tanaka H, Takeshima H, Umezawa K, Kataoka H
    • Journal Title

      Neuro-Oncology

      Volume: 14 Issue: 1 Pages: 19-28

    • DOI

      10.1093/neuonc/nor168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390114, KAKENHI-PROJECT-21590375, KAKENHI-PROJECT-22790384, KAKENHI-PROJECT-24590486
  • [Journal Article] Antitumor effect of dehydroxymethylepoxyquinomicin, a small molecule inhibitor of nuclear factor-{kappa} B, on glioblastoma2012

    • Author(s)
      Fukushima T, Kawaguchi M, Yorita K, Tanaka H, Takeshima H, Umezawa K, Kataoka H
    • Journal Title

      Neuro Oncol.

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590375
  • [Journal Article] Loss of membrane-bound serine protease inhibitor HAI-1 inducesoral squamous cell carcinoma cells' invasiveness2012

    • Author(s)
      Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H
    • Journal Title

      J Pathol

      Volume: (Epub ahead of print) Issue: 2 Pages: 181-192

    • DOI

      10.1002/path.3993

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590375, KAKENHI-PROJECT-22790384, KAKENHI-PROJECT-23790250, KAKENHI-PROJECT-24390099, KAKENHI-PROJECT-24590419, KAKENHI-PROJECT-24590486
  • [Journal Article] Urinary bladder pyogenic granuloma: a case report.2012

    • Author(s)
      Mukai S, Tanaka H, Yamasaki K, Goto T, Onizuka C, Kamoto T, Kataoka H.
    • Journal Title

      J Med Case Rep

      Volume: 6 Issue: 1 Pages: 149-149

    • DOI

      10.1186/1752-1947-6-149

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590419
  • [Journal Article] Hepatocyte growth factor activator inhibitor type 1 suppresses metastatic pulmonary colonization of pancreatic carcinoma cells.2011

    • Author(s)
      Fukushima T, Kawaguchi M, Yamasaki M, Tanaka H, Yorita K, Kataoka H
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 407-413

    • NAID

      10029290246

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Journal Article] Hepatocyte growth factor activator inhibitor type 1 suppresses metastaticpulmonary colonization of pancreatic carcinoma cells2011

    • Author(s)
      Fukushima T, Kawaguchi M, Yamasaki M, Tanaka H, Yorita K, Kataoka H
    • Journal Title

      Cancer Sci

      Volume: 102-2 Pages: 407-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590375
  • [Journal Article] Hepatocyte growth factor activator inhibitor type 1 suppresses metastatic pulmonary colonization of pancreatic carcinoma cells.2011

    • Author(s)
      Fukushima T, Kawaguchi M, Yamasaki M, Tanaka H, Yorita K, Kataoka H
    • Journal Title

      Cancer Sci 102

      Pages: 407-413

    • NAID

      10029290246

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Journal Article] Improvement ofrheumatoid arthritis and autoimmune hepatitis in a patient treated with the tumor necrosis factor inhibitor, etanercept2011

    • Author(s)
      Umekita K, Miyauchi S, Ueno S, Takajo I, Kusumoto K, Hasuike S, Umekita Y, Tanaka H, Nagata K, Nagatomo Y, Kataoka H, Shimoda K, Okayama A
    • Journal Title

      Intern Med

      Volume: 50-11 Pages: 1245-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590375
  • [Journal Article] Hepatocyte growth factor activator inhibitor type 1 suppresses metastatic pulmonary colonization of pancreatic carcinoma cells2011

    • Author(s)
      Fukushima T, Kawaguchi M, Yamasaki M, Tanaka H, Yorita K, Kataoka H
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 2 Pages: 407-413

    • DOI

      10.1111/j.1349-7006.2010.01808.x

    • NAID

      10029290246

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590375, KAKENHI-PROJECT-22790384, KAKENHI-PROJECT-23790250
  • [Journal Article] Hepatocyte growth factor activator inhibitor type 1 suppresses metastatic pulmonary colonization of pancreatic carcinoma cells2011

    • Author(s)
      Fukushima T, Kawaguchi M, Yamasaki M, Tanaka H, Yorita K, Kataoka H
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 407-413

    • NAID

      10029290246

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Journal Article] Improvement of Rheumatoid Arthritis and Autoimmune Hepatitis in a Patient Treated with the Tumor Necrosis Factor Inhibitor, Etanercept2011

    • Author(s)
      Umekita K, Miyauchi S, Ueno S, Takajo I, Kusumoto K, Hasuike S, Umekita Y, Tanaka H, Nagata K, Nagatomo Y, Kataoka H, Shimoda K, Okayama A
    • Journal Title

      Intern. Med.

      Volume: 50 Issue: 11 Pages: 1245-1249

    • DOI

      10.2169/internalmedicine.50.4879

    • NAID

      130000770480

    • ISSN
      0918-2918, 1349-7235
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590375, KAKENHI-PROJECT-22590868
  • [Journal Article] Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth2010

    • Author(s)
      Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H
    • Journal Title

      Int J Cancer

      Volume: 126-7 Pages: 1611-20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590375
  • [Journal Article] Dickkopf-1 is overexpressed in human pancreatic ductal adenoc arcinoma cells and is involved in invasive growth.2010

    • Author(s)
      Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H.
    • Journal Title

      International Journal of Cancer.

      Volume: 126(7) Pages: 1611-1620

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590375
  • [Journal Article] Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth.2010

    • Author(s)
      Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H
    • Journal Title

      International Journal of Cancer

      Volume: 126 Pages: 1611-1620

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Journal Article] Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth2010

    • Author(s)
      Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H.
    • Journal Title

      Int J Cancer 126(7)

      Pages: 1611-20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590375
  • [Journal Article] Hepatocyte growth factor activator inhibitor type 1 regulates epithelial to mesenchymal transition through membrane-bound serine proteinases2009

    • Author(s)
      Cheng H, Fukushima T, Takahashi N, Tanaka H, Kataoka H
    • Journal Title

      Cancer Res

      Volume: 69-5 Pages: 1828-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590375
  • [Journal Article] Hepatocyte growth factor activator inhibitor type 1 regulates the epithelial to mesenchymal transition through membrane-bound serine proteinases2009

    • Author(s)
      Cheng H, Fukushima T, Takahashi N, Tanaka H, Kataoka H
    • Journal Title

      Cancer Res

      Volume: 69 Pages: 1828-1835

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Journal Article] Hepatocyte growth factor activator inhibitor type 1 regulates the epithelial to mesenchymal transition through membrane-bound serine proteinases.2009

    • Author(s)
      Cheng H, Fukushima T, Takahashi N, Tanaka H, Kataoka H
    • Journal Title

      Cancer Res 69

      Pages: 1828-1835

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Journal Article] Tissue injury alters the site of expression of hepatocyte growth factor activator inhibitor type 1 in bronchial epithelial cells2009

    • Author(s)
      Tanaka H, Fukushima T, Yorita K, Kawaguchi, Kataoka H
    • Journal Title

      Human Cell

      Volume: 22 Pages: 11-17

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Journal Article] Tissue injury alters the site of expression of hepatocyte growth factor activator inhibitor type 1 in bronchial epithelial cells2009

    • Author(s)
      Tanaka H, Fukushima T, Yorita K, Kawaguchi M, Kataoka H
    • Journal Title

      Hum Cell

      Volume: 22-1 Pages: 11-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590375
  • [Journal Article] Hepatocyte growth factor activator inhibitor type 1 regulates the epithelial to mesenchymal transition through membrane-bound serine proteinases.2008

    • Author(s)
      Cheng H, Fukushima T, Takahashi N, Tanaka H, Kataoka H
    • Journal Title

      Cancer Research 69

      Pages: 1828-1835

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Journal Article] Expression of hepatocyte growth factor activator inhibitor type 1 on the epithelial cell surface is regulated by hypoxic and oxidative stresses2008

    • Author(s)
      Komaki W, Fukushima T, Tanaka H, Itoh H, Chosa E, Kataoka H
    • Journal Title

      Virchows Archiv

      Volume: 453 Pages: 347-57

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Journal Article] Tissue injury alters the site of expression of hepatocyte growth factor activator inhibitor type 1 in bronchial epithelial cells.2008

    • Author(s)
      Tanaka H, Fukushima T, Yorita K, Kawaguchi, Kataoka H
    • Journal Title

      Human Cell 22

      Pages: 11-17

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Journal Article] Activation of hepatocyte growth factor activator zymogen(pro-HGFA) by human kallikrein 1-related peptidases2008

    • Author(s)
      Mukai S, Fukushima T, Naka D, Tanaka H, Osada Y, Kataoka H
    • Journal Title

      FEBS J

      Volume: 275 Pages: 1003-1017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Journal Article] Expression of hepatocyte growth factor activator inhibitor type 1 on the epithelial cell surface is regulated by hypoxic and oxidative stresses.2008

    • Author(s)
      Komaki W, Fukushima T, Tanaka H, Itoh H, Chosa E, Kataoka H
    • Journal Title

      Virchows Archiv 453

      Pages: 347-357

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Journal Article] Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells invasiveness

    • Author(s)
      Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin C-Y, Sakoda S, Kataoka H
    • Journal Title

      J Pathol

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-20390114
  • [Presentation] 肺動脈腫瘍塞栓症を伴った前立腺癌の一剖検例2013

    • Author(s)
      田中弘之、赤木真由美、梅北佳子、賴田顕辞、福島剛、秋山裕、片岡寛章
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      ロイトン札幌、さっぽろ芸文館
    • Data Source
      KAKENHI-PROJECT-24590419
  • [Presentation] サイトメガロウイルス性腸炎にクリプトコッカス性心筋炎を合併した一剖検例2012

    • Author(s)
      田中弘之、長安真由美、賴田顕辞、梅北佳子、福島剛、片岡寛章
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京都
    • Data Source
      KAKENHI-PROJECT-24590419
  • [Presentation] Diabetic muscle infarctionと考えられた.1剖検例2011

    • Author(s)
      田中弘之、梅北佳子、頼田顕辞、福島剛、片岡寛章
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-29
    • Data Source
      KAKENHI-PROJECT-21590375
  • [Presentation] HGF activator inhibitor type 1 maintains intestinal epithelial integrity and supresses intestinal tumorigenesi2011

    • Author(s)
      Kataoka H, Hoshiko S, Kawaguchi M, Baba T, Yorita K, Tanaka H, Fukushima T
    • Organizer
      第70回日本癌学会学術総会
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Presentation] Hepatocyte growth factor activator inhibitor type 1 (HAI-1)は表皮角化細胞の形態形成を制御している2011

    • Author(s)
      川口真紀子, 星子新理, 福島剛、田中弘之, 頼田顕辞, 梅北佳子, 片岡寛章
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-29
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Presentation] Hepatocyte growth factor activator inhibitor type 1(HAI-1)の生体内機能:胎盤栄養膜細胞にぽけるHAI-1の役割に関する研究2010

    • Author(s)
      小濱和代、馬場 貴、福島剛、川口真紀子、田中弘之、片岡寛章
    • Organizer
      33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Presentation] 癌転移における膜型プロテアーゼインヒビターHAI-1の抑制的役割2010

    • Author(s)
      福島剛, 川口真紀子, 居川拓史, 馬場貴, 頼田顕辞, 田中弘之, 片岡寛章
    • Organizer
      33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Presentation] 多彩な組織像を示した卵巣明細胞腺癌の一剖検例2010

    • Author(s)
      田中弘之
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-28
    • Data Source
      KAKENHI-PROJECT-21590375
  • [Presentation] Hepatocyte growth factor activator inhibitor type 1 regulates the epithelial to mesenchymal transition.2009

    • Author(s)
      Cheng H, Fukushima T, Takahashi N, Tanaka H, Kataoka H
    • Organizer
      100th Annual Meeting of the American Association for Cancer Research.
    • Place of Presentation
      Denver, CO, USA.
    • Year and Date
      2009-04-19
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Presentation] アントラサイクリン関連心筋炎と考えられた一剖検例2009

    • Author(s)
      田中弘之
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-02
    • Data Source
      KAKENHI-PROJECT-21590375
  • [Presentation] Hepatocyte growth factor activator inhibitor type 1 regulates the epithelial to mesenchymal transition2009

    • Author(s)
      Cheng H, Fukushima T, Takahashi N, Tanaka H, Kataoka H
    • Organizer
      The 100th Annual Meeting of the American Association for Cancer Research
    • Place of Presentation
      Denver, CO, USA
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Presentation] Hepatocyte growth factor activator inhibitor type 1 regulates the epithelial to mesenchymal transition2009

    • Author(s)
      Cheng H, Fukushima T, Takahashi N, Tanaka H, Kataoka H
    • Organizer
      100th Annual Meeting of the American Association for Cancer Research
    • Place of Presentation
      Denver, CO, USA
    • Year and Date
      2009-04-19
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Presentation] Overexpression of Dickkopf-1 gene in pancreatic cancer2009

    • Author(s)
      Takahashi N, Fukushima T, Tanaka H, Chijiiwa K, Iwamura T, Kataoka H
    • Organizer
      The 100th Annual Meeting of the American Association for Cancer Research
    • Place of Presentation
      Denver, CO, USA
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Presentation] 細胞膜結合型セリンプロテアーゼインヒビターHAI-1は癌細胞の上皮・間葉転換(EMT)現象の制御に関わる2009

    • Author(s)
      片岡寛章、福島剛、頼田顕辞、田中弘之
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-03
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Presentation] HGF activator inhibitor type 1 (HAI-1)の転写制御機構の解析2008

    • Author(s)
      小牧亘, 福島剛, 田中弘之, 向井尚一郎, 片岡寛章
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-20390114
  • [Presentation] 縦隔内分泌癌を伴ったMEN type 1 の一剖検例

    • Author(s)
      田中 弘之
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-04-30 – 2015-05-02
    • Data Source
      KAKENHI-PROJECT-24590419
  • 1.  KATAOKA Hiroaki (10214321)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 35 results
  • 2.  TAKEDA Naoki (90304998)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  FUKUSHIMA Tsuyoshi (10452913)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 24 results
  • 4.  清木 元治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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