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Takazaki Shinya  高崎 伸也

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TAKAZAKI Shinya  高崎 伸也

高崎 伸世  タカザキ シンヤ

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Researcher Number 90435149
Other IDs
Affiliation (Current) 2025: 長崎国際大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help 2015: 九州大学, 大学院医学研究院, 助教
2014: 長崎国際大学, 薬学部, 講師
2009 – 2013: 九州大学, 大学病院, 助教
2012: 九州大学, 大学院・医学研究院, 助教
2011: 九州大学, 医学研究院, 助教
2006 – 2007: 崇城大学, 薬学部, 助手
Review Section/Research Field
Principal Investigator
Pathological medical chemistry
Except Principal Investigator
Laboratory medicine / Applied biochemistry / Biological Sciences
Keywords
Principal Investigator
構造解析 / ミトコンドリアDNA / TFAM / 翻訳後修飾 / ヌクレオイド / ミトコンドリア
Except Principal Investigator
ミトコンドリア病 / ミトコンドリアDNA / メタボローム / 活性酸素 … More / 遺伝子診断 / p32ノックアウトマウス / TFAM発現マウス / ミトコンドリアゲノム / ミトコンドリア / ミトコンドリアプロテアーゼ / マイトファジー / 臨床検査 / プロテオーム / transcription / venom / 毒素 / 発現調節 / ハブ / ハブ(ヘビ) / 転写 / 毒腺 / 活性酵素 / p32 / 老化 / 遺伝子多型 / 糖尿病 / 翻訳 / リボソーム Less
  • Research Projects

    (5 results)
  • Research Products

    (32 results)
  • Co-Researchers

    (13 People)
  •  Biomarkers in blood for mitochondrial abnormality

    • Principal Investigator
      Kang Dongchon
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kyushu University
  •  Human mitochondrial DNA nucleoid machinery regulated by TFAMPrincipal Investigator

    • Principal Investigator
      TAKAZAKI Shinya
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagasaki International University
      Kyushu University
  •  Analysis of mitochondrial functions in diseases

    • Principal Investigator
      KANG Dongchon
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kyushu University
  •  ミトコンドリア蛋白質の翻訳異常に伴う活性酸素の産生と細胞周期連関

    • Principal Investigator
      KANG Dongchon
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University
  •  Molecular mechanisms in regulation of gene expression in Protobothrops flavoviridis venom gland.

    • Principal Investigator
      ODA Naoko
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied biochemistry
    • Research Institution
      Sojo University

All 2012 2011 2010 2007 2006

All Journal Article Presentation

  • [Journal Article] Arg901 in the AE1 C-terminal tail is involved in conformational change but not in substrate binding2012

    • Author(s)
      Takazaki, S, Abe, Y, Yamaguchi T, Yagi M, Ueda T, Kagn D, Hamasaki N
    • Journal Title

      Biochem.Biophy.Acta

      Volume: 1819 Issue: 3 Pages: 658-665

    • DOI

      10.1016/j.bbamem.2011.11.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590322, KAKENHI-PROJECT-22249018, KAKENHI-PROJECT-23570140, KAKENHI-PROJECT-24659281, KAKENHI-PUBLICLY-23117712
  • [Journal Article] Arg 901 in the AE1 C-terminal tail is involved in conformational change but not in substrate binding2012

    • Author(s)
      Takazaki, S., Abe, Y., Yamaguchi, T., Yagi, M., Ueda, T., Kang, D., Hamasaki, N
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1818 Pages: 658-65

    • Data Source
      KAKENHI-PROJECT-22249018
  • [Journal Article] Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes,2012

    • Author(s)
      Fujino, T., Ide, T., Yoshida, M., Onitsuka, K., Tanaka, A., Hata, Y., Nishida, M., Takehara, T., Kanemaru, T., Kitajima, N., Takazaki, S., Kurose, H., Kang, D., Sunagawa, K.
    • Journal Title

      Mitochondrion

      Volume: 12 Pages: 449-458

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249018
  • [Journal Article] Arg 901 in the AE1 C-terminal tail is involved in conformational change but not in substrate binding2012

    • Author(s)
      Takazaki, S. Abe, Y. Yamaguchi, T. Yagi, M. Ueda, T. Kang, D. Hamasaki, N.
    • Journal Title

      Biochimica et Biophysica Acta - Biomembranes

      Volume: 1818 Pages: 658-65

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790370
  • [Journal Article] p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability2012

    • Author(s)
      Yagi, M., Uchiumi, T., Takazaki, S., Okuno, B., Nomura, M., Yoshida, S. I., Kanki, T., Kang, D
    • Journal Title

      Nucleic Acids Res.

      Volume: 40 Pages: 9717-9737

    • Data Source
      KAKENHI-PROJECT-22249018
  • [Journal Article] Ribonucleoprotein Y-box binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA2012

    • Author(s)
      Matsumoto S, Uchiumi T, et al
    • Journal Title

      Biochemical J

      Volume: 443 Issue: 2 Pages: 573-584

    • DOI

      10.1042/bj20111728

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590337, KAKENHI-PROJECT-21659148, KAKENHI-PROJECT-22249018, KAKENHI-PUBLICLY-23117712, KAKENHI-PROJECT-23689032, KAKENHI-PROJECT-24659281
  • [Journal Article] Dihydroorotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction2012

    • Author(s)
      Fang, J. Uchiumi, T. Yagi, M. Matsumoto, S. Amamoto, R. Takazaki, S. Yamaza, H. Nonaka, K. Kang, D.
    • Journal Title

      Bioscience reports

      Volume: 33 Issue: 2 Pages: 217-227

    • DOI

      10.1042/bsr20120097

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790370, KAKENHI-PROJECT-24590387, KAKENHI-PROJECT-24659281, KAKENHI-PROJECT-25253041
  • [Journal Article] Localization of mRNAs encoding human mitochondrial oxidative phosphorylation proteins2012

    • Author(s)
      Matsumoto, S. Uchiumi, T. Saito, T. Yagi, M. Takazaki, S. Kanki, T. Kang, D.
    • Journal Title

      Mitochondrion

      Volume: 12 Pages: 391-398

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790370
  • [Journal Article] Ribonucleoprotein Y-box-binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA2012

    • Author(s)
      Matsumoto, S., Uchiumi, T., Tanamachi, H., Saito, T., Yagi, M., Takazaki, S., Kanki, T., Kang, D.
    • Journal Title

      Biochem J.

      Volume: 443 Pages: 573-84

    • Data Source
      KAKENHI-PROJECT-22249018
  • [Journal Article] Comparative analysis of cells and proteins of pumpkin plants for the control of fruit size2012

    • Author(s)
      Ohshima Y, Nakata Y, Taniguchi G, TakazakiS, Oda-Ueda N, Miyahara K
    • Journal Title

      J. Biosci.

      Volume: 114 Issue: 3 Pages: 334-341

    • DOI

      10.1016/j.jbiosc.2012.04.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22580109, KAKENHI-PROJECT-23790370
  • [Journal Article] Recombinant mi tochondnal transcript ion factor A protein inhibits niclear factor of activated T cells signaling and attenuates2012

    • Author(s)
      Fujino T., et al
    • Journal Title

      Mitochondrion

      Volume: 4 Issue: 4 Pages: 449-458

    • DOI

      10.1016/j.mito.2012.06.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J05497, KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-23591084, KAKENHI-PROJECT-23790370
  • [Journal Article] p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA binding ability.2012

    • Author(s)
      Yagi M, Uchiumi T, Takazaki S, Okuno B, Nomura M, Yoshida S, Kanki T, Kang D
    • Journal Title

      Nuc Acid Res

      Volume: 19 Issue: 19 Pages: 9717-37

    • DOI

      10.1093/nar/gks774

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-22249018, KAKENHI-PROJECT-23591356, KAKENHI-PROJECT-23689032, KAKENHI-PROJECT-23790370, KAKENHI-PROJECT-24590387, KAKENHI-PROJECT-24659281, KAKENHI-PUBLICLY-23117712
  • [Journal Article] Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients2012

    • Author(s)
      Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Saito, T., Takazaki, S., Kanki, T., Yamaza, H., Nonaka, K., Kang, D.
    • Journal Title

      Bioscience reports

      Volume: 32 Pages: 631-639

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249018
  • [Journal Article] Protein instability and functional defect by mutations of dihydroorotate dehydrogenase with Miller syndrome patients2012

    • Author(s)
      Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Saito, T., Takazaki, S., Kanki, T., Yamaza, H., Nonaka, K., Kang, D.
    • Journal Title

      Biosci Rep.

      Volume: 32 Pages: 631-639

    • Data Source
      KAKENHI-PROJECT-22249018
  • [Journal Article] Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes2012

    • Author(s)
      Fujino, T., Ide, T., Yoshida, M., Onitsuka, K., Tanaka, A., Hata, Y., Nishida, M., Takehara, T., Kanemaru, T., Kitajima, N., Takazaki, S., Kurose, H., Kang, D., Sunagawa, K.
    • Journal Title

      Mitochondrion

      Volume: 12 Pages: 449-458

    • Data Source
      KAKENHI-PROJECT-22249018
  • [Journal Article] Dihydroorotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction2012

    • Author(s)
      Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Takazaki, S., Yamaza, H., Nonaka, K., Kang, D.
    • Journal Title

      Biosci Rep.

    • Data Source
      KAKENHI-PROJECT-22249018
  • [Journal Article] Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients.2012

    • Author(s)
      Fang J, Uchiumi T, Yagi M, Matsumoto S, Amamoto R, Saito T, Takazaki S, Kanki T, Yamaza H, Nonaka K, Kang D.
    • Journal Title

      Biosci Rep

      Volume: 32 Issue: 6 Pages: 631-639

    • DOI

      10.1042/bsr20120046

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659967, KAKENHI-PROJECT-23689032, KAKENHI-PROJECT-23790370, KAKENHI-PROJECT-23792433, KAKENHI-PROJECT-24590387
  • [Journal Article] Localization of mRNAs encoding human mitochondrial oxidative phosphorylation proteins2012

    • Author(s)
      Matsumoto, S., Uchiumi, T., Saito, T., Yagi, M., Takazaki, S., Kanki, T., Kang, D.
    • Journal Title

      Mitochondrion

      Volume: 12 Pages: 391-398

    • Data Source
      KAKENHI-PROJECT-22249018
  • [Journal Article] Ribonucleoprotein Y-box-binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA2011

    • Author(s)
      Matsumoto, S. Uchiumi, T. Tanamachi, H. Saito, T. Yagi, M. Takazaki, S. Kanki, T. Kang, D.
    • Journal Title

      Biochem J

      Volume: 443 Pages: 573-84

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790370
  • [Journal Article] Mutation of His 834 in human anion exchanger 1 affects substrate binding2010

    • Author(s)
      Takazaki, S., Abe, Y., Yamaguchi, T., Yagi, M., Ueda, T., Kang, D., Hamasaki, N
    • Journal Title

      Biochim Biophys Acta

      Volume: 1798 Pages: 903-908

    • Data Source
      KAKENHI-PROJECT-22249018
  • [Journal Article] Mutation of His 834 in human anion exchanger 1 affects substrate binding. Biochim2010

    • Author(s)
      Takazaki, S., et al.
    • Journal Title

      Biochim Biophys Acta 1798

      Pages: 903-908

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-21117511
  • [Journal Article] Mutation of His 834 in human anion exchanger 1 affects substrate binding2010

    • Author(s)
      Takazaki, S., Abe, Y., Yamaguchi, T., Yagi, M., Ueda, T., Kang, D., Hamasaki, N
    • Journal Title

      Biochim Biophys Acta

      Volume: 1798 Pages: 903-908

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-21117511
  • [Presentation] Recombinant TFAM attenuates pathological remodeling in cardiac myocytes via inhibiting NAFAT signaling2011

    • Author(s)
      Takeo Fujino, Tomomi Ide, Masayoshi Yoshida, Atushi Tanaka, Ken Onitsuka, Yuko Hata, Takako Takehara, Shinya Takazaki, Mothohiro Nishida, Dongchon Kang, Kenji Sunagawa
    • Organizer
      The 8th Conference of Asian Society for Mitochondrial Research and Medicine
    • Place of Presentation
      Kagoshima, Japan
    • Data Source
      KAKENHI-PROJECT-22249018
  • [Presentation] 奄美大島特異的な新規な[Lys^<49>]ホスホリパーゼA_22007

    • Author(s)
      村上 達夫, 狩生 徹, 高崎 伸也, 服部 正策, 千々岩 崇仁, 大野 素徳, 上田 直子
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会年会 合同年会
    • Place of Presentation
      横浜パシフィコ横浜
    • Year and Date
      2007-12-14
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18580098
  • [Presentation] Naoko Oda A novel[Lys^<49>] phospholipase A^2 from Protobothrops flavoviridis Venom2007

    • Author(s)
      Tatsuo Murakami, Tohru Tasuo, Shinya Takazaki, Shosaku Hattori, Takahito Chijiwa, Motonori Ohno
    • Organizer
      The Annual Meeting of the Japanese Biochemical Society
    • Place of Presentation
      Kyushu BranchMiyazaki, Japan
    • Year and Date
      2007-05-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18580098
  • [Presentation] A novel [Lys^<49>]phospholipase A_2 specifically expressed in the venom of Amami-Oshima island Protobothrops flavovirids2007

    • Author(s)
      Tatsuo Murakami, Tohru Kariu, Shinya Takazaki, Shosaku Hattori, Takahito Chjiwa, Motonori Ohno, Naoko Oda-Ueda
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会年会 合同年会
    • Place of Presentation
      横浜 パシフィコ横浜
    • Year and Date
      2007-12-14
    • Data Source
      KAKENHI-PROJECT-18580098
  • [Presentation] ハブ毒中の新規な[Lys^<49>]ホスホリパーゼA_2の同定2007

    • Author(s)
      村上 達夫, 狩生 徹, 高崎 伸也, 服部 正策, 千々岩 崇仁, 大野 素徳, 上田 直子
    • Organizer
      第54回毒素シンポジウム
    • Place of Presentation
      大阪府犬鳴グランドホテル
    • Year and Date
      2007-09-05
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18580098
  • [Presentation] ハブ毒中の新規な[Lys^<49>]ホスホリパーゼA2の同定2007

    • Author(s)
      村上 達夫, 狩生 徹, 高崎 伸也, 服部 正策, 千々岩 崇仁, 大野 素徳, 上田 直子
    • Organizer
      日本生化学会九州支部例会
    • Place of Presentation
      宮崎(宮崎県立図書館)
    • Year and Date
      2007-05-20
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18580098
  • [Presentation] Naoko Oda-Ueda Novel[Lys^<49>] phospholipase A^2 sspeciffically expressed in the venom of Amami-Oshima island Protobothrops flavoviridis2007

    • Author(s)
      Tatsuo Muramami, Tohru Kariu, Shinya Takazaki, Shosaku, Hattori, Takahito Chijiwa, Motnori Ohno
    • Organizer
      The 30th Annual meeting Molecular Biology Society of Japan, The 80th Annual meeting of the Japanese Biochemial Society
    • Place of Presentation
      Yokohama Japan
    • Year and Date
      2007-12-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18580098
  • [Presentation] Motonori Ohno Naoko Oda-Ueda Identification of a novel[Lys^<49>] phospholipase A_2 from Amami-Oshima P. flavoviridis venom2007

    • Author(s)
      Tatsuo Murakami, Tohru Kariu, Shinya Takazaki Shosaku Hattori, Takahito Chijiwa
    • Organizer
      The 54th Annual Meeting of Japanese society for symposium on toxins
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2007-09-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18580098
  • [Presentation] Error prone DNA polymerase κ from Protobothrops flavoviridis a member of the DinB family2006

    • Author(s)
      Naoko Oda-Ueda, Tohru, Kariu, Akiko Fukuhara, Shinya Takazaki, Takahito Chijiwa, Motonori Ohno
    • Organizer
      15th world congress on Animal, plant and Microbial Toxins
    • Place of Presentation
      Glasgow,UK
    • Year and Date
      2006-07-25
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18580098
  • [Presentation] Motonori Ohno Error prone DNA polymerase k from Protobothrops flavovirichs a member of the DinB family.2006

    • Author(s)
      Naoko Oda-Ueda, Tohru, Kariu, Akiko Fukuhara, Shinya Takazaki, Takahito Chijiwa
    • Organizer
      15th world congress on Animal, plant Microbial Toxins Glasgow
    • Place of Presentation
      UK
    • Year and Date
      2006-07-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18580098
  • 1.  KANG Dongchon (80214716)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 12 results
  • 2.  UCHIUMI Takeshi (80253798)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 7 results
  • 3.  KANKI Tomotake (50398088)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 4.  KAYAMORI Yuzo (90398066)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  ODA Naoko (70211828)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  KARIU Tohru (10412735)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 7.  MATSUSHIMA YUICI (20571342)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  YASUKAWA TAKEHIRO (90646720)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  濱崎 直孝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  小田 直子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 7 results
  • 11.  野村 政壽
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  野中 和明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  山座 治義
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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