MURATA Hiroaki 村田寛明

Researcher Number	90437856
Other IDs
External Links
Affiliation (Current)	2025: 長崎大学, 医歯薬学総合研究科(医学系), 准教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 長崎大学, 医歯薬学総合研究科(医学系), 准教授 2015 – 2016: 長崎大学, 医歯薬学総合研究科(医学系), 准教授 2010 – 2013: 長崎大学, 大学病院, 助教 2008: Nagasaki University, 大学病院, 助教 2007 – 2008: Nagasaki University, 医学部・歯学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 55050:Anesthesiology-related / Anesthesiology/Resuscitation studies / Anesthesiology
Keywords	Principal Investigator オピオイド受容体 / オピオイド / 二量体 / 細胞内局在 / 脱感作 / 急性耐性 / レミフェンタニル / 痛覚過敏 / フェンタニル / 受容体 … More / βアレスチン / 細胞内陥入 / オピオイド鎮痛薬 / glutaredoxin / 心筋保護 / 酸化ストレス / レドックス / Akt Less

オピオイド受容体の細胞内局在と活性変化に基づく最適なオピオイド順次投与法の確立Principal Investigator
- Principal Investigator
  
  村田寛明
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Nagasaki University
Development of novel analgesic strategy based on the intracellular localization analysis of opioid receptors using real time visualization assayPrincipal Investigator
- Principal Investigator
  
  MURATA Hiroaki
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Nagasaki University
Optimization of opioid therapy based on the diversity of dimerized opioid receptorsPrincipal Investigator
- Principal Investigator
  
  MURATA Hiroaki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Nagasaki University
Analysis of analgesic action of remifentanil through dimerized mu-delta opioid receptorsPrincipal Investigator
- Principal Investigator
  
  MURATA Hiroaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Nagasaki University
Molecular biological analysis of myocardial preservation via redox regulation of AktPrincipal Investigator
- Principal Investigator
  
  MURATA Hiroaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Nagasaki University

All 2023 2021 2020 2013 2012 2011 2010 2008 2007 Other

All Journal Article Presentation

[Journal Article] Distinct Profiles of Desensitization of μ-Opioid Receptors Caused by Remifentanil or Fentanyl: In Vitro Assay with Cells and Three-Dimensional Structural Analyses2023
- Author(s)
  Uezono Eiko、Mizobuchi Yusuke、Miyano Kanako、Ohbuchi Katsuya、Murata Hiroaki、Komatsu Akane、Manabe Sei、Nonaka Miki、Hirokawa Takatsugu、Yamaguchi Keisuke、Iseki Masako、Uezono Yasuhito、Hayashida Masakazu、Kawagoe Izumi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 9 Pages: 8369-8369
- DOI
  10.3390/ijms24098369
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08924, KAKENHI-PROJECT-22K06849, KAKENHI-PROJECT-20K07750, KAKENHI-PROJECT-21K06584
[Journal Article] A novel method for evaluating activity of transient receptor potential channels using a cellular dielectric spectroscopy2020
- Author(s)
  Miyano Kanako、Ohbuchi Katsuya、Sudo Yuka、Minami Kouichiro、Yokoyama Toru、Yamamoto Masahiro、Uzu Miaki、Nonaka Miki、Shiraishi Seiji、Murata Hiroaki、Higami Yoshikazu、Uezono Yasuhito
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 143 Issue: 4 Pages: 320-324
- DOI
  10.1016/j.jphs.2020.05.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08858, KAKENHI-PROJECT-19K16497, KAKENHI-PROJECT-18K07404
[Journal Article] すぐれた鎮痛効果を持ちかつ耐性形成を回避する新規モルヒネ髄腔内投与法の開発2013
- Author(s)
  村田寛明, 村上優子, 須藤結香, 村上敏史, 北條美能留, 高田正史, 倉田眞治, 澄川耕二, 上園保仁
- Journal Title
  
  臨床薬理の進歩
  
  Volume: 34 Pages: 78-85
- Data Source
  KAKENHI-PROJECT-25462442
[Journal Article] GABA(B) receptors do not internalize after baclofen treatment, possibly due to a lack of ss-arrestin association: study with a real-time visualizing assay2012
- Author(s)
  須藤結香、北條美能留、安藤優子、高田正史、村田寛明、倉田眞治、西田教行、上園保仁
- Journal Title
  
  Synapse
  
  Volume: 66 Pages: 759-769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791441
[Journal Article] GABAB receptors do not internalize after baclofen treatment, possibly due to a lack of ss-arrestin association : study with a real-time visualizing assay
- Author(s)
  須藤結香、村田寛明、上園保仁, 他
- Journal Title
  
  Synapse
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791441
[Presentation] レミフェンタニルおよびフェンタニルによるオピオイド受容体脱感作様式の解析　受容体安定発現細胞を用いて2021
- Author(s)
  上園瑛子, 溝渕有助, 宮野加奈子, 村田寛明, 山口政広, 唐澤佑輔, 山口敬介, 井関雅子, 上園保仁
- Organizer
  日本ペインクリニック学会　第55回学術集会
- Data Source
  KAKENHI-PROJECT-21K08924
[Presentation] レミフェンタニルおよびフェンタニルによるオピオイド受容体脱感作様式の解析　受容体安定発現細胞を用いて2021
- Author(s)
  上園瑛子, 溝渕有助, 宮野加奈子, 村田寛明, 山口政広, 唐澤佑輔, 山口敬介, 井関雅子, 上園保仁
- Organizer
  日本ペインクリニック学会　第55回学術集会
- Data Source
  KAKENHI-PROJECT-18K08858
[Presentation] 細胞膜移行性シグナルペプチドを付加したHaloTag-GPCR の発現様式ならびにその機能的アッセイ2012
- Author(s)
  須藤結香、宮野加奈子、村田寛明、北條美能留、長瀬隆弘、西田教行、上園保仁
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-22791441
[Presentation] 細胞移行性シグナルペプチドを付加したHaloTag-GPCRの発現様式並びにその機能的アッセイ2011
- Author(s)
  須藤結香、村田寛明、上園保仁, 他
- Organizer
  第64回薬理学会西南部会
- Place of Presentation
  福岡
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-22791441
[Presentation] Redox regulation of Akt is crucial for its cardioprotective effect.2010
- Author(s)
  Hiroaki Murata, Chiaki Inadomi, Koji Sumikawa
- Organizer
  International Anesthesia research Society 2010 Annual Meeting
- Place of Presentation
  Honolulu
- Year and Date
  2010-03-21
- Data Source
  KAKENHI-PROJECT-19791069
[Presentation] Cardioprotective effects of glutaredoxin 1 induced by suppressing S-nitrosylation of GAPDH.2008
- Author(s)
  Chiaki Inadomi, Yoshito Ihara, Hiroaki Murata, Koji Sumikawa, Takahito Kondo
- Organizer
  American Society of Anesthesiologists 2008 Annual meeting
- Place of Presentation
  Orlando
- Year and Date
  2008-10-19
- Data Source
  KAKENHI-PROJECT-19791069
[Presentation] Glutaredoxin protects nitric oxide-induced apoptosis and suppresses the oxidative modification of GAPDH.2007
- Author(s)
  稲冨千亜紀, 井原義人, 村田寛明, 澄川耕二, 近藤宇史
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19791069

1. UEZONO Yasuhito (20213340)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
2. SUDO Yuka (70646695)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. 宮野加奈子 (50597888)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results

MURATA Hiroaki 村田 寛明

Research Projects

Research Products

Co-Researchers

オピオイド受容体の細胞内局在と活性変化に基づく最適なオピオイド順次投与法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel analgesic strategy based on the intracellular localization analysis of opioid receptors using real time visualization assayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Optimization of opioid therapy based on the diversity of dimerized opioid receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of analgesic action of remifentanil through dimerized mu-delta opioid receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular biological analysis of myocardial preservation via redox regulation of AktPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Distinct Profiles of Desensitization of μ-Opioid Receptors Caused by Remifentanil or Fentanyl: In Vitro Assay with Cells and Three-Dimensional Structural Analyses2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel method for evaluating activity of transient receptor potential channels using a cellular dielectric spectroscopy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] すぐれた鎮痛効果を持ちかつ耐性形成を回避する新規モルヒネ髄腔内投与法の開発2013

Author(s)

Journal Title

Data Source

[Journal Article] GABA(B) receptors do not internalize after baclofen treatment, possibly due to a lack of ss-arrestin association: study with a real-time visualizing assay2012

Author(s)

Journal Title

Data Source

[Journal Article] GABAB receptors do not internalize after baclofen treatment, possibly due to a lack of ss-arrestin association : study with a real-time visualizing assay

Author(s)

Journal Title

Data Source

[Presentation] レミフェンタニルおよびフェンタニルによるオピオイド受容体脱感作様式の解析 受容体安定発現細胞を用いて2021

Author(s)

Organizer

Data Source

[Presentation] レミフェンタニルおよびフェンタニルによるオピオイド受容体脱感作様式の解析 受容体安定発現細胞を用いて2021

Author(s)

Organizer

Data Source

[Presentation] 細胞膜移行性シグナルペプチドを付加したHaloTag-GPCR の発現様式ならびにその機能的アッセイ2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 細胞移行性シグナルペプチドを付加したHaloTag-GPCRの発現様式並びにその機能的アッセイ2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Redox regulation of Akt is crucial for its cardioprotective effect.2010

Author(s)

Organizer

Place of Presentation

MURATA Hiroaki 村田寛明

[Presentation] レミフェンタニルおよびフェンタニルによるオピオイド受容体脱感作様式の解析　受容体安定発現細胞を用いて2021

[Presentation] レミフェンタニルおよびフェンタニルによるオピオイド受容体脱感作様式の解析　受容体安定発現細胞を用いて2021