Katano Ikumi 片野いくみ

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片野いくみカタノイクミ

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Researcher Number	90442558
Other IDs
Affiliation (Current)	2025: 公益財団法人実中研, 先端医科学研究部, 室長代理
Affiliation (based on the past Project Information) *help	2022: 公益財団法人実験動物中央研究所, 実験動物基礎研究部, 室長代理 2016 – 2018: 公益財団法人実験動物中央研究所, 実験動物研究部, 研究員 2013 – 2015: 公益財団法人実験動物中央研究所, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 42040:Laboratory animal science-related / Laboratory animal science / Tumor therapeutics
Keywords	Principal Investigator ヒト化マウス / ヒト免疫 / NK細胞 / 無菌動物 / IL-34 / ミクログリア / ヒトNK細胞 / IL-2 / IL-15 / NOGマウス … More / ADCC / hIL-2 / hIL-15 / ｈIL-2 Less

ヒトミクログリアが自然発生するヒト化マウスを用いた無菌環境での脳恒常性破綻の解明Principal Investigator
- Principal Investigator
  
  片野いくみ
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Central Institute for Experimental Animals
Development of in vivo cytotoxicity assay system using humanized mice maintaining human mature NK cells for long-termPrincipal Investigator
- Principal Investigator
  
  Katano Ikumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
Development of in vivo cytotoxicity assay system using humanized mice increasing human natural killer cellsPrincipal Investigator
- Principal Investigator
  
  Katano Ikumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Central Institute for Experimental Animals

All 2022 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Patent

[Journal Article] Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse2017
- Author(s)
  Katano Ikumi、Nishime Chiyoko、Ito Ryoji、Kamisako Tsutomu、Mizusawa Takuma、Ka Yuyo、Ogura Tomoyuki、Suemizu Hiroshi、Kawakami Yutaka、Ito Mamoru、Takahashi Takeshi
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 17230-17230
- DOI
  10.1038/s41598-017-17442-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07103, KAKENHI-PROJECT-26221005, KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-16K18405
[Journal Article] A novel xenogeneic graft-versus-host disease model for investigating the pathological role of human CD4+ or CD8+ T cells using immunodeficient NOG mice.2017
- Author(s)
  Ito R, Katano I, Kawai K, Yagoto M, Takahashi T, Ka Y, Ogura T, Takahashi R, Ito M
- Journal Title
  
  American Journal of Transplantation
  
  Volume: 5 Issue: 5 Pages: 1216-1228
- DOI
  10.1111/ajt.14116
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290034, KAKENHI-PROJECT-16K07103, KAKENHI-PROJECT-16K18405, KAKENHI-PROJECT-17H03571
[Journal Article] Antitumor Effect of Programmed Death-1 (PD-1) Blockade in Humanized the NOG-MHC Double Knockout Mouse.2017
- Author(s)
  Ashizawa T, Iizuka A, Nonomura C, Kondou R, Maeda C, Miyata H, Sugino T, Mitsuya K, Hayashi N, Nakasu Y, Maruyama K, Yamaguchi K, Katano I, Ito M, Akiyama Y.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 23(1) Issue: 1 Pages: 149-158
- DOI
  10.1158/1078-0432.ccr-16-0122
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430178, KAKENHI-PROJECT-16K08727, KAKENHI-PROJECT-16K18405
[Journal Article] Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing.2016
- Author(s)
  Sato K, Oiwa R, Kumita W, Henry R, Sakuma T, Ito R, Nozu R, Inoue T, Katano I, Sato K, Okahara N, Okahara J, Shimizu Y, Yamamoto M, Hanazawa K, Kawakami T, Kametani Y, Suzuki R, Takahashi T, Weinstein EJ, Yamamoto T, Sakakibara Y, Habu S, Hata J, Okano H, Sasaki E.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 19 Issue: 1 Pages: 127-138
- DOI
  10.1016/j.stem.2016.06.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290034, KAKENHI-PROJECT-16K07103, KAKENHI-PROJECT-16K18405, KAKENHI-PROJECT-16K18478
[Journal Article] Visualization of the human CD4(+) T-cell response in humanized HLA-DR4-expressing NOD/Shi-scid/gammac(null) (NOG) mice by retrogenic expression of the human TCR gene2015
- Author(s)
  Takahashi, T. Katano, I. Ito, R. Ito, M.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 456 Issue: 1 Pages: 219-224
- DOI
  10.1016/j.bbrc.2014.11.062
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-25430099, KAKENHI-PROJECT-25871075, KAKENHI-PROJECT-26290034
[Journal Article] Predominant Development of Mature and Functional Human NK Cells in a Novel Human IL-2-Producing Transgenic NOG Mouse2015
- Author(s)
  Katano, I. Takahashi, T. Ito, R. Kamisako, T. Mizusawa, T. Ka, Y. Ogura, T. Suemizu, H. Kawakami, Y. Ito, M.
- Journal Title
  
  J Immunol
  
  Volume: 194 Issue: 7 Pages: 3513-3525
- DOI
  10.4049/jimmunol.1401323
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-25871075, KAKENHI-PROJECT-26221005, KAKENHI-PROJECT-26290034, KAKENHI-PROJECT-25430099
[Journal Article] NOD-Rag2null IL-2Rγnull mice: an alternative to NOG mice for generation of humanized mice.2014
- Author(s)
  Katano I, Ito R, Kamisako T, Eto T, Ogura T, Kawai K, Suemizu H, Takahashi T, Kawakami Y, Ito M.
- Journal Title
  
  Exp Anim
  
  Volume: 63 Pages: 321-330
- NAID
  130004677826
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25871075
[Journal Article] A novel enhanced green fluorescent protein-expressing NOG mouse for analyzing the microenvironment of xenograft tissues.2014
- Author(s)
  Higuchi Y, Kawai K, Yamamoto M, Kuronuma M, Ando Y, Katano I, Nakamura M, Suemizu H.
- Journal Title
  
  Exp Anim
  
  Volume: 63 Pages: 55-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25871075
[Journal Article] Establishment of a Human Allergy Model Using Human IL-3/GM-CSF-Transgenic NOG Mice.2013
- Author(s)
  Ito, R., T. Takahashi, I. Katano, K. Kawai, T. Kamisako, T. Ogura, M. Ida-Tanaka, H. Suemizu, S. Nunomura, C. Ra, A. Mori, S. Aiso, and M. Ito.
- Journal Title
  
  J Immunol
  
  Volume: 191 Issue: 6 Pages: 2890-2899
- DOI
  10.4049/jimmunol.1203543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-23590561, KAKENHI-PROJECT-25430099, KAKENHI-PROJECT-25871075
[Patent] 免疫不全マウス2018
- Inventor(s)
  高橋武司、片野いくみ
- Industrial Property Rights Holder
  高橋武司、片野いくみ
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-217229
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16K18405
[Patent] ヒトIL-15分泌免疫不全マウス2016
- Inventor(s)
  伊藤守、片野いくみ
- Industrial Property Rights Holder
  伊藤守、片野いくみ
- Industrial Property Rights Type
  特許
- Filing Date
  2016-04-20
- Overseas
- Data Source
  KAKENHI-PROJECT-16K18405
[Patent] ヒトIL-15分泌免疫不全マウス2015
- Inventor(s)
  伊藤守、片野いくみ
- Industrial Property Rights Holder
  伊藤守、片野いくみ
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-107932
- Filing Date
  2015-05-27
- Data Source
  KAKENHI-PROJECT-25871075
[Presentation] A novel ischemic infarction model using humanized NOG-IL-34 Tg mouse2022
- Author(s)
  Ikumi Katano, Takeshi Takahashi, Mamoru Ito
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K06059
[Presentation] NOG-FcgR KO-hIL-15 Tg mice provide a highly sensitive assay system for ADCC activity of human NK cells2019
- Author(s)
  Ikumi Katano, Iyo Ootsuka, Ryoji Ito, Kenji Kawai, Mika Yagoto, Hiroshi Suemizu, Mamoru Ito, Taichi Yamamoto, Takeshi Takahashi
- Organizer
  AACR Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18405
[Presentation] Specific detection of human NK cell mediated in vivo ADCC in FcgR-deficient NOG-human IL-15 transgenic mice2018
- Author(s)
  Ikumi Katano, Asami Hanazawa, Ryoji Ito, Mamoru Ito, Takeshi Takahashi
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K18405
[Presentation] Human interleukin-15 transgenic NOG mice support the long-term maintenance of human mature NK cells from peripheral blood2016
- Author(s)
  Ikumi Katano, Takeshi Takahashi, Ryoji Ito, Asami Hanazawa, Mamoru Ito
- Organizer
  5th International Workshop on Humanized Mice (IWHM5)
- Place of Presentation
  Switzerland, University of Zurich
- Year and Date
  2016-01-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25871075
[Presentation] ヒトIL-15遺伝子導入NOGマウスはヒト末梢血由来成熟NK細胞を長期間維持できる2015
- Author(s)
  片野いくみ、高橋武司、伊藤亮治、花澤麻美、高橋利一、末水洋志、河上裕、伊藤守
- Organizer
  第６２回日本実験動物学会総会
- Place of Presentation
  京都、京都テルサ
- Year and Date
  2015-05-27
- Data Source
  KAKENHI-PROJECT-25871075
[Presentation] Human interleukin-15 transgenic NOG mice support the long-term maintenance of human mature NK cells from peripheral blood2015
- Author(s)
  Ikumi Katano, Takeshi Takahashi, Ryoji Ito, Asami Hanazawa, Yutaka Kawakami, Mamoru Ito
- Organizer
  第４４回日本免疫学会学術集会
- Place of Presentation
  札幌、札幌コンベンションセンター
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-25871075
[Presentation] Functional NK cells developed from human hematopoietic stem cell in human interleukin-2 transgenic NOG mice2013
- Author(s)
  Ikumi Katano, Ryoji Ito, Takeshi Takahashi, Mamoru Ito
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  イタリア・ミラノ(Mico)
- Data Source
  KAKENHI-PROJECT-25871075
[Presentation] Predominant Development of Mature and Functional Human NK Cells in a Novel Human IL-2 Producing Transgenic NOD-scid,IL-2Rg KO (NOG) Mouse2013
- Author(s)
  Ikumi Katano, Takeshi Takahashi, Ryoji Ito, Mamoru Ito
- Organizer
  The 4th International Workshop on Humanized Mice (IWHM4)
- Place of Presentation
  韓国・ソウル
- Data Source
  KAKENHI-PROJECT-25871075
[Presentation] Characterization of human Eosinophil in HSC-transferred NOG-human IL-5 transgenic mice2013
- Author(s)
  Ikumi Katano, Takeshi Takahashi, Ryoji Ito, Mamoru Ito
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉・幕張メッセ
- Data Source
  KAKENHI-PROJECT-25871075
[Presentation] ヒトIL-15遺伝子導入NOGマウスはヒト末梢血由来成熟NK細胞を長期間維持できる
- Author(s)
  片野いくみ、高橋武司、伊藤亮治、花澤麻美、高橋利一、末水洋志、河上裕、伊藤守
- Organizer
  第62回日本実験動物学会総会
- Place of Presentation
  京都テルサ
- Year and Date
  2015-05-28 – 2015-05-30
- Data Source
  KAKENHI-PROJECT-25871075

1. ITO Ryoji

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
2. SUEMIZU Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 高橋武司

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
4. 伊藤守

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 秋山靖人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 飯塚明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Katano Ikumi 片野 いくみ

片野 いくみ カタノ イクミ

Research Projects

Research Products

Co-Researchers

ヒトミクログリアが自然発生するヒト化マウスを用いた無菌環境での脳恒常性破綻の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of in vivo cytotoxicity assay system using humanized mice maintaining human mature NK cells for long-termPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of in vivo cytotoxicity assay system using humanized mice increasing human natural killer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel xenogeneic graft-versus-host disease model for investigating the pathological role of human CD4+ or CD8+ T cells using immunodeficient NOG mice.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antitumor Effect of Programmed Death-1 (PD-1) Blockade in Humanized the NOG-MHC Double Knockout Mouse.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Visualization of the human CD4(+) T-cell response in humanized HLA-DR4-expressing NOD/Shi-scid/gammac(null) (NOG) mice by retrogenic expression of the human TCR gene2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predominant Development of Mature and Functional Human NK Cells in a Novel Human IL-2-Producing Transgenic NOG Mouse2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NOD-Rag2null IL-2Rγnull mice: an alternative to NOG mice for generation of humanized mice.2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] A novel enhanced green fluorescent protein-expressing NOG mouse for analyzing the microenvironment of xenograft tissues.2014

Author(s)

Journal Title

Data Source

[Journal Article] Establishment of a Human Allergy Model Using Human IL-3/GM-CSF-Transgenic NOG Mice.2013

Author(s)

Journal Title

DOI

Data Source

[Patent] 免疫不全マウス2018

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] ヒトIL-15分泌免疫不全マウス2016

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

Katano Ikumi 片野いくみ

片野いくみカタノイクミ