Murase Kazuyuki 村瀬和幸

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MURASE Kazuyuki 村瀬和幸

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Researcher Number	90444918
Affiliation (Current)	2025: 札幌医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2019 – 2023: 札幌医科大学, 医学部, 講師 2017: 札幌医科大学, 医学部, 講師 2015 – 2017: 札幌医科大学, 医学部, 助教 2009 – 2010: Sapporo Medical University, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Hematology / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Tumor diagnostics / Hematology
Keywords	Principal Investigator 標的抗がん治療法 / 標的抗がん治療法 / 難治性軟部肉腫 / 免疫原性細胞死 / AYA世代 / BH3 profiling / 高次元サイトメトリー法 / 高次元サイトメトリー / Treg / GVHD … More / 脂質 / 再生医学 / 癌 / 核酸 / 移植・再生医療 … More Except Principal Investigator 膵癌 / ドラッグデリバリー / ドラッグデリバリーシステム / グライコミクス / biomarker / フコシル化 / 細胞外小胞 / 白血病幹細胞 / 骨髄間質 / 間葉系幹細胞 / エキソソーム / PCBP1 / 骨髄間質細胞 / 骨髄異形成症候群 / 白血病 / マイクロRNA / エクソソーム Less

AYA世代難治性軟部肉腫に対する免疫原性細胞死を利用した新規抗がん治療法の開発Principal Investigator
- Principal Investigator
  
  村瀬和幸
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Sapporo Medical University
Development of a Novel DDS with Tumor-Directed Anticancer Drugs for Pancreatic Cancer
- Principal Investigator
  
  Kato Junji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Sapporo Medical University
Development of a new targeted anticancer treatment for Adolescent and Young Adult refractory soft tissue sarcomaPrincipal Investigator
- Principal Investigator
  
  Murase Kazuyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Sapporo Medical University
Development of novel cancer diagnostic method by detection of sugar chain in urine using glycomics analysis
- Principal Investigator
  
  Kato Junji
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor diagnostics
- Research Institution
  Sapporo Medical University
The effect of exosomal miRNA on AML/MDS stromal cells
- Principal Investigator
  
  Kobune Masayoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Sapporo Medical University
Comprehensive analysis of GVHD regulated cells by high dimensional cytometry and identification of prognostic factorsPrincipal Investigator
- Principal Investigator
  
  Murase Kazuyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Sapporo Medical University
Development of liver cancer preventive methods using VA-Lip-siRNAPrincipal Investigator
- Principal Investigator
  
  MURASE Kazuyuki
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University

All 2017 2016 2015 2014 2011 2010 2009

All Journal Article Presentation

[Journal Article] Small molecule CP-31398 induces reactive oxygen species-dependent apoptosis in human multiple myeloma2017
- Author(s)
  Arihara Yohei、Takada Kohichi、Kamihara Yusuke、Hayasaka Naotaka、Nakamura Hajime、Murase Kazuyuki、Ikeda Hiroshi、Iyama Satoshi、Sato Tsutomu、Miyanishi Koji、Kobune Masayoshi、Kato Junji
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 39 Pages: 65889-65899
- DOI
  10.18632/oncotarget.19508
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07178, KAKENHI-PROJECT-17H03599, KAKENHI-PROJECT-15K09482
[Journal Article] Activated p53 with Histone Deacetylase Inhibitor Enhances L-Fucose-Mediated Drug Delivery through Induction of Fucosyltransferase 8 Expression in Hepatocellular Carcinoma Cells.2016
- Author(s)
  Okagawa Y, Murase K, Kato J, et al
- Journal Title
  
  PLoS One.
  
  Volume: 15 Issue: 12 Pages: e0168355-e0168355
- DOI
  10.1371/journal.pone.0168355
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09508, KAKENHI-PROJECT-16K07178, KAKENHI-PROJECT-16K14624
[Journal Article] Narrow-Band Ultraviolet B Phototherapy Ameliorates Acute Graft-Versus-Host Disease of the Intestine by Expansion of Regulatory T Cells.2016
- Author(s)
  Hashimoto A, Murase K, Kato J. et al
- Journal Title
  
  PLoS One
  
  Volume: 31 Issue: 3 Pages: e0152823-e0152823
- DOI
  10.1371/journal.pone.0152823
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09508, KAKENHI-PROJECT-25461429, KAKENHI-PROJECT-25461430, KAKENHI-PROJECT-26670178, KAKENHI-PROJECT-26670386
[Journal Article] The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/β-catenin signaling in human multiple myeloma.2016
- Author(s)
  Kamihara Y, Murase K, Kato J, et al
- Journal Title
  
  Oncotarget
  
  Volume: 27 Issue: 39 Pages: 64330-64341
- DOI
  10.18632/oncotarget.11830
- NAID
  120006576953
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09508, KAKENHI-PROJECT-16K07178, KAKENHI-PROJECT-16K14624
[Journal Article] Neurolymphomatosis of the sciatic nerve diagnosed by FDG-PET/CT2016
- Author(s)
  Usami M, Murase K, Kato J. et al
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 57 Issue: 1 Pages: 52-55
- DOI
  10.11406/rinketsu.57.52
- NAID
  130005125846
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09508
[Journal Article] Extracellular vesicle miR-7977 is involved in hematopoietic dysfunction of mesenchymal stromal cells via poly(rC) binding protein 1 reduction in myeloid neoplasms.2016
- Author(s)
  Horiguchi H, Murase K, Kato J. et al
- Journal Title
  
  Haematologica
  
  Volume: 101 Issue: 4 Pages: 437-447
- DOI
  10.3324/haematol.2015.134932
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09508, KAKENHI-PROJECT-25461430, KAKENHI-PROJECT-26670386
[Journal Article] A phase II trial of small-dose bortezomib, lenalidomide and dexamethasone (sVRD) as consolidation/maintenance therapy in patients with multiple myeloma.2016
- Author(s)
  Ibata S, Murase K, Kato J, et al
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: 78 Pages: 1041-1049
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09508
[Journal Article] Effect of duloxetine in Japanese patients with chemotherapy-induced peripheral neuropathy: a pilot randomized trial.2015
- Author(s)
  Hirayama Y, Ishitani K, Sato Y, Iyama S, Takada K, Murase K, Kuroda H, Nagamachi Y, Konuma Y, Fujimi A, Sagawa T, Ono K, Horiguchi H, Terui T, Koike K, Kusakabe T, Sato T, Takimoto R, Kobune M, Kato J
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 20 Issue: 5 Pages: 866-871
- DOI
  10.1007/s10147-015-0810-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09482, KAKENHI-PROJECT-15K09508, KAKENHI-PROJECT-25461430
[Journal Article] A dose-escalation study of oxaliplatin/capecitabine/irinotecan (XELOXIRI) and bevacizumab as a first-line therapy for patients with metastatic colorectal cancer.2015
- Author(s)
  Sato Y, Ohnuma H, Hirakawa M, Takahashi M, Osuga T, Okagawa Y, Murase K, Takada K, Kawano Y, Iyama S, Hayashi T, Sato T, Miyanishi K, Takimoto R, Kobune M, Okita K, Mizuguchi T, Furuhata T, Hirata K, Kato J
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 75 Issue: 3 Pages: 587-597
- DOI
  10.1007/s00280-014-2672-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659592, KAKENHI-PROJECT-25461430, KAKENHI-PROJECT-26461037, KAKENHI-PROJECT-26670386, KAKENHI-PROJECT-15K09508
[Journal Article] BAK is a predictive and prognostic biomarker for the therapeutic effect of docetaxel treatment in patients with advanced gastric cancer.2015
- Author(s)
  Kubo T, Murase K, Kato J. et al
- Journal Title
  
  Gastric Cancer.
  
  Volume: 20
- NAID
  40020881713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09508
[Journal Article] RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells2014
- Author(s)
  Tamura F, Sato Y, Hirakawa M, Yoshida M, Ono M, Osuga T, Okagawa Y, Uemura N, Arihara Y, Murase K, Kawano Y, Iyama S, Takada K, Hayashi T, Sato T, Miyanishi K, Kobune M, Takimoto R, Kato J.
- Journal Title
  
  Gastric Cancer
  
  Volume: 23 Issue: 1 Pages: 85-97
- DOI
  10.1007/s10120-014-0454-z
- NAID
  40020700032
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590921, KAKENHI-PROJECT-24591403, KAKENHI-PROJECT-26461037, KAKENHI-PROJECT-26670386, KAKENHI-PROJECT-15K09508
[Journal Article] Tuberculous pleuritis with onset of refractory pleural effusion after chemoradiotherapy for esophageal cancer.2011
- Author(s)
  Hirakawa M, Sato Y, Ohnuma H, Sagawa T, Ishiwatari H, Murase K, Iyama S, Hayashi T, Sato T, Miyanishi K, Kobune M, Takimoto R, Kato J.
- Journal Title
  
  Nippon Shokakibyo Gakkai Zasshi 108(2)
  
  Pages: 231-237
- NAID
  10029388119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790674
[Journal Article] Two cases of myelodysplastic syndrome associated with pyoderma gangrenosum.2011
- Author(s)
  Murase K, Sato T, Takimoto R, Kobune M, Kato J.
- Journal Title
  
  Rinsho zasshi Naika. In press.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790674
[Journal Article] Endoscopic findings of enteropathy-type T-cell lymphoma by double-balloon enteroscopy and capsule endoscopy.2010
- Author(s)
  Sato Y, Murase K
- Journal Title
  
  Dig Endosc
  
  Volume: 22 Pages: 243-5
- NAID
  10028187103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790674
[Journal Article] Endoscopic findings of enteropathy-type T-cell lymphoma by double-balloon enteroscopy and capsule endoscopy.2010
- Author(s)
  Sato Y, Ono M, Sagawa T, Takimoto R, Hirakawa M, Ohnuma H, Sato T, Iyama S, Murase K, Miyanishi K, Kobune M, Kato J.
- Journal Title
  
  Dig Endosc 22(3)
  
  Pages: 243-245
- NAID
  10028187103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790674
[Journal Article] Evaluation of the efficacy of liposomal amphotericin B.2010
- Author(s)
  Iyama S, Murase K
- Journal Title
  
  Kansenshogaku Zasshi
  
  Volume: 84 Pages: 182-6
- NAID
  10026893557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790674
[Journal Article] Evaluation of the efficacy of liposomal amphotericin B.2010
- Author(s)
  Iyama S, Murase K, Sato T, Kikuchi S, Sato Y, Kobune M, Takimoto R, Kato J.
- Journal Title
  
  Kansenshogaku Zasshi 84(2)
  
  Pages: 182-186
- NAID
  10026893557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790674
[Journal Article] Therapeutic results in patients with biphenotypic acute leukemia at Sapporo Medical University Hospital.2010
- Author(s)
  Murase K, Kato J.
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 37 Pages: 2011-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790674
[Journal Article] Therapeutic results in patients with biphenotypic acute leukemia at Sapporo Medical University Hospital.2010
- Author(s)
  Murase K, Iyama S, Sato T, Takimoto R, Kobune M, Kato J.
- Journal Title
  
  Gan To Kagaku Ryoho 37(10)
  
  Pages: 2011-2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790674
[Journal Article] Drug resistance is dramatically restored by hedgehog inhibitors in CD34^+ leukemic cells.2009
- Author(s)
  Kobune M, Takimoto R, Murase K, Iyama S, Sato T, Kikuchi S, Kawano Y, Miyanishi K, Sato Y, Niitsu Y, Kato J.
- Journal Title
  
  Cancer Sci 100(5)
  
  Pages: 948-955
- NAID
  10025145994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790674
[Journal Article] Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells.2009
- Author(s)
  Kobune M, Murase K, et al
- Journal Title
  
  Cancer science 100(5)
  
  Pages: 948-955
- NAID
  10025145994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790674
[Presentation] Exosomal microRNAs in bone marrow cavity induce stromal dysfunction in AML/MDS2015
- Author(s)
  Hiroto Horiguchi, Masayoshi Kobune, Shohei Kikuchi, Kazuyuki Murase, Satoshi Iyama, Kohichi Takada, Tsutomu Sato, Yasushi Sato1), Koji Miyanishi1), Rishu Takimoto, Hiroyuki Kuroda, Masahiro Maeda, Junji Kato
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県金沢市ホテル日航金沢
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K09482
[Presentation] Ex vivo production of mature erythroblasts using coculture with cord blood medical human stromal cells2010
- Author(s)
  菊地尚平、村瀬和幸
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21790674

1. Kato Junji (20244345)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. 高田弘一 (90398321)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. Kobune Masayoshi (90336389)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 佐藤勉 (40404602)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 堀口拓人 (70634674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 松野鉄平 (60774221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 大須賀崇裕 (40619714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 濱口孝太 (50866613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 宮西浩嗣 (60372819)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 在原洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 佐藤康史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 瀧本理修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 平川昌宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 水口徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 佐藤昇志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 平田公一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Murase Kazuyuki 村瀬 和幸

MURASE Kazuyuki 村瀬 和幸

Research Projects

Research Products

Co-Researchers

AYA世代難治性軟部肉腫に対する免疫原性細胞死を利用した新規抗がん治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a Novel DDS with Tumor-Directed Anticancer Drugs for Pancreatic Cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new targeted anticancer treatment for Adolescent and Young Adult refractory soft tissue sarcomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel cancer diagnostic method by detection of sugar chain in urine using glycomics analysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of exosomal miRNA on AML/MDS stromal cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive analysis of GVHD regulated cells by high dimensional cytometry and identification of prognostic factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of liver cancer preventive methods using VA-Lip-siRNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Small molecule CP-31398 induces reactive oxygen species-dependent apoptosis in human multiple myeloma2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activated p53 with Histone Deacetylase Inhibitor Enhances L-Fucose-Mediated Drug Delivery through Induction of Fucosyltransferase 8 Expression in Hepatocellular Carcinoma Cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Narrow-Band Ultraviolet B Phototherapy Ameliorates Acute Graft-Versus-Host Disease of the Intestine by Expansion of Regulatory T Cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/β-catenin signaling in human multiple myeloma.2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Neurolymphomatosis of the sciatic nerve diagnosed by FDG-PET/CT2016

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Extracellular vesicle miR-7977 is involved in hematopoietic dysfunction of mesenchymal stromal cells via poly(rC) binding protein 1 reduction in myeloid neoplasms.2016

Author(s)

Journal Title

DOI

Murase Kazuyuki 村瀬和幸

MURASE Kazuyuki 村瀬和幸