HIGASHI Tsunehito 東恒仁

… Alternative Names

Higashi Tsunehito 東恒仁

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Researcher Number	90453018
Other IDs
External Links
Affiliation (Current)	2025: 岡山理科大学, 獣医学部, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 北海道大学, 医学研究院, 助教 2016: 北海道大学, 医学研究科, 助教 2014 – 2015: 北海道大学, 医学(系)研究科(研究院), 助教 2008 – 2009: Fukushima Medical University, 医学部, 助教 2008: 福県立医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 63030:Chemical substance influence on environment-related / General pharmacology / Biofunction/Bioprocess Except Principal Investigator Structural biochemistry
Keywords	Principal Investigator プロテインキナーゼC / 不飽和カルボニル化合物 / 細胞死 / フェロトーシス / 細胞傷害 / 炎症 / 抗酸化物質 / タバコ煙抽出物 / 血管平滑筋細胞 / 細胞毒性 … More / タバコ煙ガス相 / 全反射顕微鏡 / 品質管理 / 小胞体 / 動物細胞工学 … More Except Principal Investigator 全反射顕微鏡 / 蛍光相関分光法 / 1分子イメージング / フォールディング / 分子イメージング / 品質管理 / 1分子動態 / 小胞体 / 分泌系 / 糖鎖 / 一分子トラッキング / ダイナミクス / 細胞小器官 Less

不飽和カルボニル化合物によるPKC依存性フェロトーシスを介した炎症誘導機構の解明Principal Investigator
- Principal Investigator
  
  東恒仁
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Hokkaido University
Elucidation of molecular mechanisms for PKC-dependent ferroptosis induced by unsaturated carbonyl compoundsPrincipal Investigator
- Principal Investigator
  
  Higashi Tsunehito
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Hokkaido University
The role of PKC for unsaturated carbonyl compounds-induced cell injury and disease onsetPrincipal Investigator
- Principal Investigator
  
  HIGASHI Tsunehito
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Hokkaido University
Elucidation of molecular mechanism for development of atherosclerosis by cytotoxic factors in cigarette smokePrincipal Investigator
- Principal Investigator
  
  Higashi Tsunehito
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Hokkaido University
Basic research for improvement of productivity of bio-medicines based on cell quality control systemPrincipal Investigator
- Principal Investigator
  
  HIGASHI Tsunehito
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Fukushima Medical University
Studies on gating and permission mechanisms for maturation of secretory cargo proteins
- Principal Investigator
  
  WADA Ikuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Fukushima Medical University

All 2023 2022 2021 2020 2019 2018 2016 2015 2014 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Protein kinase Cβ is involved in cigarette smoke gas phase-induced ferroptosis in J774 macrophages2023
- Author(s)
  Higashi Tsunehito、Handa Haruka、Mai Yosuke、Maenaka Katsumi、Tadokoro Takashi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 153 Issue: 1 Pages: 22-25
- DOI
  10.1016/j.jphs.2023.06.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K12253
[Journal Article] Decreased Proteasomal Function Induces Neuronal Loss and Memory Impairment2021
- Author(s)
  Tomaru Utano、Ito Tomoki、Ohmura Yu、Higashikawa Kei、Miyajima Syota、Tomatsu Ruka、Higashi Tsunehito、Ishizu Akihiro、Kuge Yuji、Yoshioka Mitsuhiro、Kasahara Masanori
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 191 Issue: 1 Pages: 144-156
- DOI
  10.1016/j.ajpath.2020.10.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02629, KAKENHI-PROJECT-18K07545, KAKENHI-PROJECT-18K11654, KAKENHI-PROJECT-20K21512
[Journal Article] Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells2020
- Author(s)
  Sampilvanjil Ariunaa、Karasawa Tadayoshi、Yamada Naoya、Komada Takanori、Higashi Tsunehito、Baatarjav Chintogtokh、Watanabe Sachiko、Kamata Ryo、Ohno Nobuhiko、Takahashi Masafumi
- Journal Title
  
  American Journal of Physiology-Heart and Circulatory Physiology
  
  Volume: 318 Issue: 3 Pages: H508-H518
- DOI
  10.1152/ajpheart.00559.2019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-18K11654, KAKENHI-PROJECT-19K21319
[Journal Article] Autoantibodies undetectable by chemiluminescent enzyme immunoassay require extended antigen-antibody reaction time for detection2019
- Author(s)
  Mai Y, Ujiie H, Higashi T, Yamagami J, Iwata H, Shimizu H
- Journal Title
  
  Br J Dermatol
  
  Volume: 180 Issue: 1 Pages: 215-216
- DOI
  10.1111/bjd.17121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11654
[Journal Article] Glutathione and cysteines suppress cytotoxicity of gas phase of cigarette smoke by direct reacting with unsaturated carbonyl compounds in the gas phase2019
- Author(s)
  Higashi Tsunehito、Elmeligy Enas、Mai Yosuke、Noya Yoichi、Terada Koji、Mazaki Yuichi、Kuge Yuji、Miwa Soichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 509 Issue: 4 Pages: 988-993
- DOI
  10.1016/j.bbrc.2019.01.040
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08423, KAKENHI-PROJECT-18K11654
[Journal Article] Pyrenocine A induces monopolar spindle formation and suppresses proliferation of cancer cells2019
- Author(s)
  Myobatake Yusuke、Kamisuki Shinji、Tsukuda Senko、Higashi Tsunehito、Chinen Takumi、Takemoto Kenji、Hachisuka Masami、Suzuki Yuka、Takei Maya、Tsurukawa Yukine、Maekawa Hiroaki、Takeuchi Toshifumi、Matsunaga Tomoko M.、Sahara Hiroeki、Usui Takeo、Matsunaga Sachihiro、Sugawara Fumio
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 23 Pages: 115149-115149
- DOI
  10.1016/j.bmc.2019.115149
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05343, KAKENHI-PROJECT-18K11654, KAKENHI-PROJECT-19K05726, KAKENHI-ORGANIZER-15H05955, KAKENHI-PLANNED-15H05962, KAKENHI-PROJECT-19H03259
[Journal Article] Endothelin type B receptor interacts with the 78-kDa glucose-regulated protein.2019
- Author(s)
  Mazaki, Y., Higashi, T., Onodera, Y., Nam, JM., Hashimoto, A., Hashimoto, S., Horinouchi, T., and Miwa, S.
- Journal Title
  
  FEBS Lett
  
  Volume: 593(6) Issue: 6 Pages: 644-651
- DOI
  10.1002/1873-3468.13347
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07151, KAKENHI-PROJECT-17K08614, KAKENHI-PROJECT-18K08423, KAKENHI-PROJECT-18K11654
[Journal Article] Annexin A2 is involved in activation of extracellular signal-regulated kinase upon endothelin-1 stimulation2019
- Author(s)
  Mazaki Yuichi、Higashi Tsunehito、Horinouchi Takahiro、Miwa Soichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 511 Issue: 1 Pages: 69-72
- DOI
  10.1016/j.bbrc.2019.02.040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08423, KAKENHI-PROJECT-18K11654
[Journal Article] Mitofusin 2 is involved in chemotaxis of neutrophil-like differentiated HL-60 cells2019
- Author(s)
  Mazaki Yuichi、Takada Shingo、Nio-Kobayashi Junko、Maekawa Satoshi、Higashi Tsunehito、Onodera Yasuhito、Sabe Hisataka
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 513 Issue: 3 Pages: 708-713
- DOI
  10.1016/j.bbrc.2019.04.037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K14603, KAKENHI-PROJECT-18K08423, KAKENHI-PROJECT-18K11654, KAKENHI-PROJECT-19K22791, KAKENHI-PROJECT-17H04758, KAKENHI-PROJECT-17K08502
[Journal Article] Protein kinase C-dependent cell damage by unsaturated carbonyl compounds in vascular cells2018
- Author(s)
  Higashi T, Mai Y, Mazaki Y
- Journal Title
  
  J Biosci Bioeng
  
  Volume: 126 Issue: 4 Pages: 527-532
- DOI
  10.1016/j.jbiosc.2018.04.020
- NAID
  40021697445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11654
[Journal Article] A Standardized Method for the Preparation of a Gas Phase Extract of Cigarette Smoke2016
- Author(s)
  Higashi T, Mai Y, Mazaki Y, Horinouchi T, Miwa S
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 6 Pages: 898-902
- DOI
  10.1248/bpb.b16-00062
- NAID
  130005155132
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860166
[Journal Article] Using Phos-Tag in western blotting analysis to evaluate protein phosphorylation2016
- Author(s)
  Horinouchi T, Terada K, Higashi T, Miwa S
- Journal Title
  
  Methods Mol Biol
  
  Volume: 1397 Pages: 267-277
- DOI
  10.1007/978-1-4939-3353-2_18
- ISBN
  9781493933518, 9781493933532
- Data Source
  KAKENHI-PROJECT-26860166
[Journal Article] A standard method for preparation of gas phase extract of cigarette smoke2016
- Author(s)
  Higashi T, Mai Y, Mazaki Y, Horinouchi T, Miwa S
- Journal Title
  
  Bull Pharm Biol
  
  Volume: in press
- NAID
  130005155132
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860166
[Journal Article] Endothelin-1 suppresses insulin-stimulated Akt phosphorylation and glucose uptake via GPCR kinase 2 in skeletal muscle cells2016
- Author(s)
  Horinouchi T, Hoshi A, Harada T, Higa T, Karki S, Terada T, Higashi T, Mai Y, Nepal P, Mazaki Y, Miwa S
- Journal Title
  
  Br J Pharmacol
  
  Volume: 173 Issue: 6 Pages: 1018-1032
- DOI
  10.1111/bph.13406
- NAID
  120005981358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860166, KAKENHI-PROJECT-25460326
[Journal Article] The dynamics of mucosal-associated invariant T cells in multiple sclerosis2016
- Author(s)
  Chie Sugimoto, Makoto Hirotan, Kazunori Yoshikiyo, Uichi Koshimizu, Rika Wakao, Takahiro Horinouchi, Yuichi Mazaki, Tsunehiko Higashi, Toshiyuki Fukazawa, Hiroyoshi Fujita, Hidenao Sasaki and Hiroshi Wakao
- Journal Title
  
  SpringerPlus
  
  Volume: 5 Issue: 1 Pages: 1259-1259
- DOI
  10.1186/s40064-016-2923-9
- NAID
  120005906931
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430084, KAKENHI-PROJECT-26860166
[Journal Article] Carbonyl Compounds in the Gas Phase of Cigarette Mainstream Smoke and Their Pharmacological Properties2016
- Author(s)
  Horinouchi T, Higashi T, Mazaki Y, Miwa S
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 6 Pages: 909-914
- DOI
  10.1248/bpb.b16-00025
- NAID
  130005155133
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860166
[Journal Article] Ubiquitination-regulated receptor trafficking of endothelin type A and type B receptors2015
- Author(s)
  寺田晃士、堀之内孝広、東恒仁、Prabha Nepal、三輪聡一
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 145 Issue: 1 Pages: 4-9
- DOI
  10.1254/fpj.145.4
- NAID
  130004827712
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-26860166
[Journal Article] Decreased proteosomal function accelerates cigarette smoke-induced pulmonary emphysema in mice.2015
- Author(s)
  Yamada Y, Tomaru U, Ishizu A, Ito T, Kiuchi T, Ono A, Miyajima S, Nagai K, Higashi T, Matsuno Y, Dosaka-Akita H, Nishimura M, Miwa S, Kasahara M
- Journal Title
  
  Lab Invest
  
  Volume: 95 Issue: 6 Pages: 625-634
- DOI
  10.1038/labinvest.2015.43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860166, KAKENHI-PROJECT-15H04716, KAKENHI-PROJECT-24590441, KAKENHI-PROJECT-25461181
[Journal Article] A simple and rapid method for standard preparation of gas phase extract of cigarette smoke.2014
- Author(s)
  Higashi T., Mai Y., Noya Y., Horinouchi T., Terada K., Hoshi A., Nepal P., Harada T., Horiguchi M., Hatate C., Kuge Y. and Miwa S.
- Journal Title
  
  PLos ONE
  
  Volume: 9 Issue: 9 Pages: e107856-e107856
- DOI
  10.1371/journal.pone.0107856
- NAID
  120005496512
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460326, KAKENHI-PROJECT-26860166
[Journal Article] Endothelin-1 activates extracellular signal-regulated kinases 1/2 via transactivation of platelet-derived growth factor receptor in rat L6 myoblasts.2014
- Author(s)
  Harada T, Horinouchi T, Higa T, Hoshi A, Higashi T, Terada K, Mai Y, Nepal P, Horiguchi M, Hatate C, Miwa S.
- Journal Title
  
  Life Sci.
  
  Volume: 104 Issue: 1-2 Pages: 24-31
- DOI
  10.1016/j.lfs.2014.04.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390059, KAKENHI-PROJECT-25460326, KAKENHI-PROJECT-26860166
[Journal Article] 移植細胞の動態観察のためのin vivo蛍光・発光標識法2009
- Author(s)
  東恒仁
- Journal Title
  
  サージェリーフロンティア 16
  
  Pages: 79-84
- Data Source
  KAKENHI-PROJECT-20760541
[Journal Article] 移植細胞の動態観察のためのIn vivo蛍光・発光標識法2009
- Author(s)
  東恒仁、野本幸男、小林謙、大森孝一、和田郁夫
- Journal Title
  
  サージェリーフロンティア 16巻
  
  Pages: 79-84
- Data Source
  KAKENHI-PROJECT-20760541
[Presentation] 不飽和カルボニル化合物は肺小細胞がんSBC-3細胞に対してPKC依存的にフェロトーシスを誘導する2023
- Author(s)
  東恒仁、半田悠、眞井洋輔、前仲勝実、田所高志
- Organizer
  第74回薬理学会北部会
- Data Source
  KAKENHI-PROJECT-21K12253
[Presentation] タバコ煙ガス相はJ774マクロファージにおいてPKCbetaを介してフェロトーシスを誘導する2023
- Author(s)
  東恒仁、半田悠、眞井洋輔、前仲勝実、田所高志
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K12253
[Presentation] 気管上皮細胞に対するタバコ煙の作用の分子的解明2022
- Author(s)
  東恒仁、眞井洋輔、真崎雄一
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K12253
[Presentation] タバコ煙ガス相は気管上皮細胞に対してPKC依存的にフェロトーシスを誘導する2022
- Author(s)
  東恒仁、眞井洋輔、真崎雄一
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K12253
[Presentation] In vitroアッセイによる環境毒性因子の呼吸器系への影響の解明2022
- Author(s)
  東恒仁、眞井洋輔、真崎雄一
- Organizer
  日本動物細胞工学会2022年度大会
- Data Source
  KAKENHI-PROJECT-21K12253
[Presentation] 不飽和カルボニル化合物の毒性メカニズムと生理作用の解明2021
- Author(s)
  東恒仁、真崎雄一
- Organizer
  環境ホルモン学会第23回研究発表会
- Invited
- Data Source
  KAKENHI-PROJECT-21K12253
[Presentation] タバコ煙タール相による細胞死誘導メカニズム2020
- Author(s)
  東恒仁、真崎雄一
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K11654
[Presentation] Protein kinase C b is involved in unsaturated carbonyl compounds-induced cell death in macrophages2020
- Author(s)
  Tsunehito HIgashi, Yuichi Mazaki
- Organizer
  JAACT2020 Fuchu
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11654
[Presentation] 不飽和カルボニル化合物による細胞死に関与するPKCアイソフォームの同定2020
- Author(s)
  東恒仁、真崎雄一
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11654
[Presentation] システイン誘導体による煙中の不飽和カルボニル化合物の解毒メカニズムの解明2019
- Author(s)
  東恒仁、Enas Elmeligy、眞井洋輔、野矢洋一、真崎雄一、久下裕司、三輪聡一
- Organizer
  第71回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-18K11654
[Presentation] 抗酸化物質によるタバコ煙ガス相の分子メカニズムの解明2019
- Author(s)
  東恒仁、Enas Elmeligy、眞井洋輔、野矢洋一、久下裕司、真崎雄一、三輪聡一
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K11654
[Presentation] Molecular mechanism for unsaturated carbonyl compounds-induced vascular cell death2018
- Author(s)
  Tsunehito Higashi, Yosuke Mai, Yuichi Mazaki
- Organizer
  ASCB/EMBO 2018 Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11654
[Presentation] 不飽和カルボニル化合物が血管構成細胞に及ぼす影響の解明2018
- Author(s)
  東恒仁、眞井洋輔、真崎雄一
- Organizer
  第70回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-18K11654
[Presentation] 不飽和カルボニル化合物はプロテインキナーゼC依存的に心血管系細胞の細胞死を誘導する2018
- Author(s)
  東恒仁、眞井洋輔、真崎雄一
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11654
[Presentation] Unsaturated carbonyl compounds in the gas phase extract of cigarette smoke induce cell death through intracellular Ca2+-dependent PKC activation2016
- Author(s)
  Higashi T, Mai Y, Mazaki Y, Horinouchi T, Miwa S
- Organizer
  American Society for Cell Biology 2016 Annual Meeting
- Place of Presentation
  San Francisco (USA)
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860166
[Presentation] タバコ煙ガス相による細胞傷害の抑制因子の探索と抑制メカニズムの解明2016
- Author(s)
  東恒仁、眞井洋輔、堀之内孝広、真崎雄一、三輪聡一
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜会議センター（神奈川県横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-26860166
[Presentation] タバコ煙に起因する細胞傷害の抑制物質の探索と抑制メカニズムの解明2015
- Author(s)
  東恒仁、眞井洋輔、堀之内孝広、真崎雄一、堀口美香、三輪聡一
- Organizer
  第25回日本循環薬理学会
- Place of Presentation
  東大寺総合文化センター金鐘ホール（奈良県奈良市）
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26860166
[Presentation] タバコ煙に起因する細胞傷害の抑制方法の開発およびその分子機構の解明2015
- Author(s)
  東恒仁、眞井洋輔、堀之内孝広、真崎雄一、堀口美香、三輪聡一
- Organizer
  第66回日本薬理学会北部会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-26860166
[Presentation] タバコ煙による細胞傷害の定量的検出方法の確立と細胞傷害抑制物質の探索2014
- Author(s)
  旗手千鶴、東恒仁、Enas Elmeligy、眞井洋輔、堀之内孝広、寺田晃士、星暁壮、Prabha Nepal、Sarita Karki、堀口美香、原田拓弥、三輪聡一
- Organizer
  第65回日本薬理学会北部会
- Place of Presentation
  コラッセふくしま（福島県・福島市）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26860166
[Presentation] タバコ煙中の細胞傷害因子の同定とその細胞傷害メカニズムの解明2014
- Author(s)
  東恒仁
- Organizer
  日本生物物理学会北海道支部会・北海道分子生物学研究会・日本生化学会2014年度合同シンポジウム
- Place of Presentation
  北海道大学農学部（北海道・札幌市）
- Year and Date
  2014-11-19
- Invited
- Data Source
  KAKENHI-PROJECT-26860166
[Presentation] DCP1のP-body への局在にはそのC末端領域が必要である2009
- Author(s)
  東恒仁、和田郁夫
- Organizer
  第22回日本動物細胞工学会大会
- Place of Presentation
  東京
- Year and Date
  2009-07-25
- Data Source
  KAKENHI-PROJECT-19370044
[Presentation] Jump distance analysis によるアスパラギン結合糖鎖を持つカーゴ動態の解析2009
- Author(s)
  和田郁夫、東恒仁、田中学
- Organizer
  第82回日本生化学会年会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-19370044
[Presentation] Role of Dcp1 in the formation of P-bodies.2009
- Author(s)
  Higashi T, Wada, I.
- Organizer
  Biophysical Society 53rd Anneal Meeting
- Year and Date
  2009-03-04
- Data Source
  KAKENHI-PROJECT-19370044
[Presentation] Jump distance analysisが示すカーゴタンパク質成熟化におけるアスパラギン結合糖鎖の役割2009
- Author(s)
  和田郁夫、東恒仁、田中学
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸市
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20760541
[Presentation] Probing the environment of the endoplasmic reticulum lumen by analyzing jump distance of a cargo protein2009
- Author(s)
  Saisuke Arai, Tsunehito Higashi, Gaku Tanaka, Ikuo Wada
- Organizer
  4th Cell Stress Society International(CSSI)Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  札幌
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-19370044
[Presentation] Probing the environment of the endoplasmic reticulum lumen by analyzing jump distance of a cargo protein.2009
- Author(s)
  Arai S, Higashi T, Tanaka G, Wada I.
- Organizer
  4th Cell Stress Society International (CSSI) Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-19370044
[Presentation] Probing the environment of the endoplasmic reticulum lumen by analyzing jump distance of a cargo protein.2009
- Author(s)
  Seisuke Arai, Tsunehito Higashi, Gaku Tanaka, Ikuo Wada
- Organizer
  4th Cell Stress Society International (CSSI) Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-20760541
[Presentation] Role of Dcp1 in the formation of P-bodies2009
- Author(s)
  Tsunehito Higashi, Ikuo Wada
- Organizer
  Biophysical Society 53rd Anneal Meeting
- Place of Presentation
  Long Beach(CA)
- Year and Date
  2009-03-04
- Data Source
  KAKENHI-PROJECT-19370044
[Presentation] DCP1のP-bodyへの局在にはそのC末端領域が必要である2009
- Author(s)
  東恒仁、和田郁夫
- Organizer
  第22回日本動物細胞工学会大会
- Place of Presentation
  筑波
- Year and Date
  2009-07-25
- Data Source
  KAKENHI-PROJECT-19370044
[Presentation] P-body形成におけるDCP1の役割2008
- Author(s)
  東恒仁, 和田郁夫
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19370044
[Presentation] P-body形成におけるDCP1の役割2008
- Author(s)
  東恒仁
- Organizer
  第31回日本分子生物学会
- Place of Presentation
  神戸市
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20760541
[Presentation] Regulated motion of cargo proteins in the endoplasmic reticulum as revealed by single molecule techniques2008
- Author(s)
  Higashi T, et al.
- Organizer
  Joint Meeting of the Biophysical Society 52nd Anneal Meeting & 16th International Biophysics Congress
- Place of Presentation
  Longbeach, LA, USA
- Year and Date
  2008-02-06
- Data Source
  KAKENHI-PROJECT-19370044
[Presentation] Regulated motion of cargo proteins in the endoplasmic reticulum as revealed by single molecule techniques.2008
- Author(s)
  Higashi Y, Nagaya H, Tanaka G, Abe M, Wada I.
- Organizer
  Joint Meeting of the Biophysical Society 52nd Anneal Meeting & 16th International Biophysics Congress
- Place of Presentation
  LongBeach, CA
- Year and Date
  2008-02-06
- Data Source
  KAKENHI-PROJECT-19370044
[Presentation] P-body 形成におけるDCP1の役割2008
- Author(s)
  東恒仁、和田郁夫
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19370044
[Presentation] 二光子レーザー顕微法を用いた細胞小器官の操作2008
- Author(s)
  渡辺歴、東恒仁
- Organizer
  第20回動物細胞工学シンポジウム
- Place of Presentation
  東京都
- Year and Date
  2008-08-04
- Data Source
  KAKENHI-PROJECT-20760541
[Presentation] 小胞体内におけるカーゴ蛋白質1分子ダイナミクスの解析2007
- Author(s)
  東恒仁, 中西秀樹, 大橋功一, 和田郁夫
- Organizer
  第30回日本分子生物学会年会第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19370044
[Presentation] グルタチオン・N-アセチルシステイン・システインはタバコ煙ガス相抽出物による細胞傷害に対する保護作用を有する
- Author(s)
  東恒仁、眞井洋輔、Enas Elmeligy、堀之内孝広、寺田晃士、星暁壮、堀口美香、Prabha Nepal、Sarita Karki、旗手千鶴、三輪聡一
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26860166
[Presentation] Gas phase extract of cigarette smoke and its cytotoxic components induce cell death via protein kinase C and NADPH oxidase
- Author(s)
  Higashi T, Mai Y, Horinouchi T, Terada K, Elmeligy E, Hoshi A, Nepal P, Harada T, Karki S, Horiguchi M, Hatate C, Miwa S
- Organizer
  The 2014 ascb/ifcb Meeting
- Place of Presentation
  Philadelphia (United States of America)
- Year and Date
  2014-12-06 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-26860166

1. WADA Ikuo (40182969)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
2. HATSUZAWA Kiyotaka (20256655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. HASHIMOTO Hitoshi (50372826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NAKANISHI Hideki (30457783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. MAI Yosuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
6. KAMISUKI Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. TERADA Koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. ONODERA Yasuhito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 真崎雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 三輪聡一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 橋本茂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 高橋将文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 唐澤直義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 渡邊幸子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 石津明洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 外丸詩野

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 杉本智恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 藤田博美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 若尾宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIGASHI Tsunehito 東 恒仁

Higashi Tsunehito 東 恒仁

Research Projects

Research Products

Co-Researchers

不飽和カルボニル化合物によるPKC依存性フェロトーシスを介した炎症誘導機構の解明Principal Investigator

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Elucidation of molecular mechanisms for PKC-dependent ferroptosis induced by unsaturated carbonyl compoundsPrincipal Investigator

Principal Investigator

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The role of PKC for unsaturated carbonyl compounds-induced cell injury and disease onsetPrincipal Investigator

Principal Investigator

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Review Section

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Elucidation of molecular mechanism for development of atherosclerosis by cytotoxic factors in cigarette smokePrincipal Investigator

Principal Investigator

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Basic research for improvement of productivity of bio-medicines based on cell quality control systemPrincipal Investigator

Principal Investigator

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Studies on gating and permission mechanisms for maturation of secretory cargo proteins

Principal Investigator

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[Journal Article] Protein kinase Cβ is involved in cigarette smoke gas phase-induced ferroptosis in J774 macrophages2023

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[Journal Article] Decreased Proteasomal Function Induces Neuronal Loss and Memory Impairment2021

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[Journal Article] Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells2020

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[Journal Article] Autoantibodies undetectable by chemiluminescent enzyme immunoassay require extended antigen-antibody reaction time for detection2019

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[Journal Article] Glutathione and cysteines suppress cytotoxicity of gas phase of cigarette smoke by direct reacting with unsaturated carbonyl compounds in the gas phase2019

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[Journal Article] Pyrenocine A induces monopolar spindle formation and suppresses proliferation of cancer cells2019

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[Journal Article] Endothelin type B receptor interacts with the 78-kDa glucose-regulated protein.2019

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[Journal Article] Annexin A2 is involved in activation of extracellular signal-regulated kinase upon endothelin-1 stimulation2019

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HIGASHI Tsunehito 東恒仁

Higashi Tsunehito 東恒仁