Goto Yoshikuni 後藤芳邦

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GOTO Yoshikuni 後藤芳邦

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Researcher Number	90455345
Other IDs	https://orcid.org/0000-0001-9908-2197
Affiliation (Current)	2024: 帝京平成大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2022: 帝京平成大学, 薬学部, 准教授 2013 – 2016: 帝京平成大学, 薬学部, 講師 2012 – 2014: 帝京平成大学, 薬学部, 助教 2010: Teikyo Heisei University, 薬学部, 助教 2010: 独立行政法人理化学研究所, 薬学部, 助教 2009: The Institute of Physical and Chemical Research, 辻本細胞生化学研究室, 基礎科学特別研究員 2008: 独立行政法人理化学研究所, 辻本細胞生学研究室, 基礎科学特別研究員
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Pathological medical chemistry / Biological pharmacy / Applied biochemistry Except Principal Investigator Pathological medical chemistry / Environmental and hygienic pharmacy / Biological pharmacy
Keywords	Principal Investigator アミノペプチダーゼ / 貪食 / LPS / 一酸化窒素 / マクロファージ / セロトニン / 不安障害 / 抗原提示 / エキソソーム / サイトカイン … More / インターフェロン / MHCクラスI / MHCクラスI抗原提示 / トリプトファン水酸化酵素 / モノアミン / TPH2 / セロトニン神経 / 自己免疫疾患 / HLA分子 / ケモカイン / ベーチェット病 / 炎症 / トール様受容体 / リポ多糖 / 分泌 / 血圧調節 … More Except Principal Investigator ERAP1 / 一酸化窒素 / 小胞体アミノペプチダーゼ / ノックアウトマウス / LPS / マクロファージ / 貪食 / インターフェロンーγ / エキソソーム / 細胞間情報伝達 / Toll like receptor 4 / 唾液 / DPP IV / exosome / 高架式十字迷路試験 / 強制水泳試験 / 尾懸垂試験 / ERAP1-/-マウス / 遺伝子欠損マウス / セロトニン / カルモジュリン / MyD88 / Toll-様受容体 / アルギニン / M1アミノペプチダーゼ / NO産生 / 高血圧症 / インターフェロン / アンギオテンシンIV / 立体構造解析 / 胎盤性ロイシンアミノペプチダーゼ / 白血球由来アルギニンアミノペップチダーゼ / アミノペプチダーゼA / リーベリン / 白血球由来アルギニンアミノペプチダーゼ / 脂肪細胞由来ロイシンアミノペプチダーゼ / オキシトシナーゼサブファミリー / 一塩基多型 / 基質特異性 / アミノペプチダーゼ Less

MHCクラスI抗原提示の機能不全が惹起する脳内セロトニン過剰疾患「不安障害」Principal Investigator
- Principal Investigator
  
  後藤芳邦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Teikyo Heisei University
Dysfunction of ERAP1 induces anxiety disorder via excess serotonin synthesisPrincipal Investigator
- Principal Investigator
  
  GOTO Yoshikuni
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Teikyo Heisei University
Roles of ER aminopeptidase 1 in inflammation of Behcet's diseasePrincipal Investigator
- Principal Investigator
  
  GOTO Yoshikuni
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Teikyo Heisei University
Role of ERAP1 in the pathogenesis of mental disorders
- Principal Investigator
  
  TSUJIMOTO MASAFUMI
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Teikyo Heisei University
Pathophysiological roles of M1 aminopeptidases
- Principal Investigator
  
  TSUJIMOTO Masafumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Teikyo Heisei University
Molecular mechanism and regulation of immune activation cascade by aminopeptidase contained exosome.
- Principal Investigator
  
  OGAWA Yuko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Teikyo Heisei University
Role of aminopeptidases in atherosclerosis
- Principal Investigator
  
  TSUJIMOTO Masafumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Teikyo Heisei University
Contribution of ER-aminopeptidase secretion to classical activation of macrophagesPrincipal Investigator
- Principal Investigator
  
  GOTO Yoshikuni
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo Heisei University
Regulation of blood pressure by secreted adipocyte-derived leucine aminopeptidasePrincipal Investigator
- Principal Investigator
  
  GOTO Yoshikuni
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Teikyo Heisei University
  The Institute of Physical and Chemical Research
Mechanisms of Enzymatic Action of the Oxytocinase Subfamily of Aminopeptidases
- Principal Investigator
  
  TSUJIMOTO Masafumi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Institute of Physical and Chemical Research

[Journal Article] Diurnal variations of triglyceride accumulation in mouse and bovine adipocyte‐derived cell lines2022
- Author(s)
  Shiraishi Rena、Morita Satomi、Goto Yoshikuni、Mizoguchi Yasushi、Nakamura Wataru、Nakamura Takahiro J.
- Journal Title
  
  Animal Science Journal
  
  Volume: 93 Issue: 1
- DOI
  10.1111/asj.13802
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07271, KAKENHI-PROJECT-22K06914, KAKENHI-PROJECT-17K08564
[Journal Article] Stability of human salivary extracellular vesicles containing dipeptidyl peptidase IV under simulated gastrointestinal tract conditions2021
- Author(s)
  Ogawa Yuko、Akimoto Yoshihiro、Ikemoto Mamoru、Goto Yoshikuni、Ishikawa Anna、Ohta Sakura、Takase Yumi、Kawakami Hayato、Tsujimoto Masafumi、Yanoshita Ryohei
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 27 Pages: 101034-101034
- DOI
  10.1016/j.bbrep.2021.101034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07405, KAKENHI-PROJECT-20K07162
[Journal Article] Molecular and functional diversity of the oxytocinase subfamily of M1 aminopeptidases2021
- Author(s)
  Tsujimoto Masafumi、Aoki Kazuma、Goto Yoshikuni、Ohnishi Atsushi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 169 Issue: 4 Pages: 409-420
- DOI
  10.1093/jb/mvab009
- NAID
  40022588048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07405, KAKENHI-PROJECT-17K08461
[Journal Article] Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain2020
- Author(s)
  Goto Yoshikuni、Nakamura Takahiro J.、Ogawa Kenji、Hattori Akira、Tsujimoto Masafumi
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 7 Pages: 168-168
- DOI
  10.3389/fmolb.2020.00168
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06360, KAKENHI-PROJECT-19K07405, KAKENHI-PROJECT-17H04022
[Journal Article] Endoplasmic Reticulum Aminopeptidase 1 beyond Antigenic Peptide-Processing Enzyme in the Endoplasmic Reticulum2020
- Author(s)
  Tsujimoto Masafumi、Aoki Kazuma、Ohnishi Atsushi、Goto Yoshikuni
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 2 Pages: 207-214
- DOI
  10.1248/bpb.b19-00857
- NAID
  130007793742
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-02-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07405, KAKENHI-PROJECT-17K08461
[Journal Article] Endoplasmic reticulum aminopeptidases as multifunctional enzymes2019
- Author(s)
  辻本雅文、青木一真、大西敦、後藤芳邦
- Journal Title
  
  生化学
  
  Volume: 91 Issue: 5 Pages: 666-680
- DOI
  10.14952/SEIKAGAKU.2019.910666
- ISSN
  0037-1017
- Year and Date
  2019-10-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07405
[Journal Article] Acute-phase protein-like properties of endoplasmic reticulum aminopeptidase 1.2019
- Author(s)
  Goto Y, Nakamura TJ, Ogawa K, Hattori A, Tsujimoto M.
- Journal Title
  
  J Biochem.
  
  Volume: 165 Issue: 2 Pages: 159-165
- DOI
  10.1093/jb/mvy090
- NAID
  40021809947
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07114, KAKENHI-PROJECT-16K08630
[Journal Article] Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation2018
- Author(s)
  Goto Yoshikuni、Ogawa Yuko、Tsumoto Hiroki、Miura Yuri、Nakamura Takahiro J.、Ogawa Kenji、Akimoto Yoshihiro、Kawakami Hayato、Endo Tamao、Yanoshita Ryohei、Tsujimoto Masafumi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  
  Volume: 1865 Issue: 6 Pages: 874-888
- DOI
  10.1016/j.bbamcr.2018.03.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08630, KAKENHI-PROJECT-16K08348
[Journal Article] Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages2015
- Author(s)
  Yoshikuni Goto, Kenji Ogawa, Takahiro J Nakamura, Akira Hattori, Masafumi Tsujimoto
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 157 Issue: 6 Pages: 439-49
- DOI
  10.1093/jb/mvv001
- NAID
  40020489236
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24659153, KAKENHI-PROJECT-26860160, KAKENHI-PROJECT-25293083
[Journal Article] Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages2015
- Author(s)
  Goto Y., Ogawa K., Nakamura T.J., Hattori A., Tsujimoto M.
- Journal Title
  
  J. Biochem.
  
  Volume: 印刷中
- NAID
  40020489236
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790083
[Journal Article] Involvement of Phenylalanine 297 in the Construction of the Substrate Pocket of Human Aminopeptidase B.2015
- Author(s)
  Ohnishi A., Watanabe J., Ogawa Y., Goto Y., Hattori A., Tsujimoto M.
- Journal Title
  
  Biochemistry
  
  Volume: 54(39) Issue: 39 Pages: 6062-70
- DOI
  10.1021/acs.biochem.5b00964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460172, KAKENHI-PROJECT-25293083
[Journal Article] Substrate-dependentnitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages2015
- Author(s)
  Goto, Y., Ogawa, K., Nakamura, T.J., Hattori, A. and Tsujimoto, M.
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 157 Pages: 439-449
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15088
[Journal Article] Role of glutamine-169 in the substrate recognition of human aminopeptidase B2014
- Author(s)
  Ogawa Y, Ohnishi A, Goto Y, Sakuma Y, Watanabe J, Hattori A, Tsujimoto M
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1840 Issue: 6 Pages: 1872-1881
- DOI
  10.1016/j.bbagen.2014.01.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310160, KAKENHI-PROJECT-24659099, KAKENHI-PROJECT-24790083, KAKENHI-PROJECT-25293083, KAKENHI-PROJECT-25460172
[Journal Article] Role of glutamine-169 in the substrate recognition of human aminopeptidase B2014
- Author(s)
  Ogawa Y., Ohnishi A., Goto Y., Sakuma Y., Watanabe J., Hattori A., Tsujimoto M.
- Journal Title
  
  Biochim. Biophys. Acta.
  
  Volume: 1840 Pages: 1872-1881
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790083
[Journal Article] TLR-Mediated Secretion of Endoplasmic Reticulum Aminopeptidase 1 from Macrophages2014
- Author(s)
  Goto Y, Ogawa K, Nakamura TJ, Hattori A, Tsujimoto M.
- Journal Title
  
  J Immunol
  
  Volume: 192 Issue: 9 Pages: 4443-4452
- DOI
  10.4049/jimmunol.1300935
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23310160, KAKENHI-PROJECT-24659099, KAKENHI-PROJECT-24659153, KAKENHI-PROJECT-24790083, KAKENHI-PROJECT-24790238, KAKENHI-PROJECT-25293083, KAKENHI-PROJECT-26860160
[Journal Article] Exon 10 coding sequence is important for endoplasmic reticulum retention of endoplasmic reticulum minopeptidase 12012
- Author(s)
  Akira Hattori, Yoshikuni Goto Masafumi Tsujimoto
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume: 35 Pages: 601-605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659153
[Journal Article] Exon 10 Coding Sequence Is Important for Endoplasmic Reticulum Retention of Endoplasmic Reticulum Aminopeptidase 12012
- Author(s)
  Hattori A, Goto Y & Tsujimoto M
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 35 Issue: 4 Pages: 601-605
- DOI
  10.1248/bpb.35.601
- NAID
  130001872211
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310160, KAKENHI-PROJECT-24659099, KAKENHI-PROJECT-24790083, KAKENHI-PUBLICLY-23133504
[Journal Article] Involvement of glutamine-238 in the substrate specificity of human laeverin/aminopeptidase Q.2011
- Author(s)
  Goto Y, Yoshioka R, Arisaka N, Hattori A, Tsujimoto M.
- Journal Title
  
  Biol Pharm Bull. 34
  
  Pages: 24-27
- NAID
  130000402257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21780103
[Journal Article] Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-γ.2011
- Author(s)
  Goto Y, Ogawa K, Hattori A, Tsujimoto M.
- Journal Title
  
  J Biol Chem. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21780103
[Journal Article] Involvement of glutamine-238 in the substrate specificity of human laeverin/aminopeptidase Q2011
- Author(s)
  Yoshikuni Goto
- Journal Title
  
  Biological & Pharmaceutical Bulletin
  
  Volume: 34 Pages: 24-27
- NAID
  130000402257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21780103
[Journal Article] Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme.2011
- Author(s)
  Evnouchidou I, Kamal RP, Seregin SS, Goto Y, Tsujimoto M, Hattori A, Voulgari PV, Drosos AA, Amalfitano A, York IA, Stratikos E.
- Journal Title
  
  J Immunol. 186
  
  Pages: 1909-1913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21780103
[Journal Article] Glutamine-181 is crucial in the enzymatic activity and substrate specificity of human endoplasmic reticulum aminopeptidase-12008
- Author(s)
  Goto, Y., Tanji, H., Hattori, A. and Tsujimoto, M.
- Journal Title
  
  Biochem. J. 416
  
  Pages: 109-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Glutamine-181 is crucial in the enzymatic activity and substrate specificity of human endoplasmic reticulum aminopeptidase-12008
- Author(s)
  Yoshikuni Goto
- Journal Title
  
  Biochemical Journal 416
  
  Pages: 109-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Biochemical and enzymatic properties of M1 family of aminopeptidases involved in the regulation of blood pressure2008
- Author(s)
  Tsujimoto, M., Goto, Y., Maruyama, M. and Hattori, A.
- Journal Title
  
  Heart Fail. Rev. 13
  
  Pages: 285-291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Laeverin/aminopeptidase Q, a novel bestatin sensitive leucine aminopeptidase belonging to the M1 family of aminopsptidases2007
- Author(s)
  Maruyama, M., Hattori, A., Goto, Y., Ueda, M., Maeda, M., Fujiwara, H. and Tsujimoto, M.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 20088-20096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Asparatic acid-221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A2007
- Author(s)
  Goto, Y., Hattori, A., Mizutani, S, and Tsujimoto, M.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 37074-37081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Asparatic acid 221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A2007
- Author(s)
  Yoshikuni Goto
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages: 37074-37081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidas(A-LAP)/ER-aminopeptidase-12006
- Author(s)
  Goto Y.
- Journal Title
  
  FEBS Lett. 580
  
  Pages: 1833-1838
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Enzymatic properties of human aminopeptidase A2006
- Author(s)
  Goto Y.
- Journal Title
  
  J.Biol.Chem. 281
  
  Pages: 23503-23513
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-12006
- Author(s)
  Goto, Y., Hattori, A., Ishii, Y. and Tsujimoto, M.
- Journal Title
  
  FEBS Lett. 580
  
  Pages: 1833-1838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Enzymatic properties of human aminopeptidase A; regulation of its enzymatic activity by calcium and angiotensin IV2006
- Author(s)
  Goto, Y., Hattori, A., Ishii, Y., Mizutani, S. and Tsujimoto, M.
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 23503-23513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-γ
- Author(s)
  Yoshikuni Goto
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21780103
[Presentation] 小胞体アミノペプチダーゼ1機能不全は,脳内セロトニン動態異常を介して不安行動を惹起する2022
- Author(s)
  平井杏奈, 鈴木優香, 中村孝博, 小川健司, 服部明, 辻本雅文, 後藤芳邦
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-22K06914
[Presentation] Trypanosoma brucei に対する宿主マクロファージの生体防御反応2021
- Author(s)
  後藤　芳邦、辻本　雅文、野元　裕、中西　雅之
- Organizer
  第90回日本寄生虫学会・第32回日本臨床寄生虫学会合同大会
- Data Source
  KAKENHI-PROJECT-19K07405
[Presentation] Trypanosoma brucei由来VSGによるマクロファージの活性化2020
- Author(s)
  後藤芳邦、津元裕樹、三浦ゆり、遠藤玉夫、野元裕、辻本雅文、中西雅之
- Organizer
  第89回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-19K07405
[Presentation] バソプレシン分解酵素P-LAP の脳内局在と概日リズム2019
- Author(s)
  小島雄太郎, 後藤芳邦, 中村孝博, 辻本雅文
- Organizer
  日本薬学会　第139年会
- Data Source
  KAKENHI-PROJECT-16K08630
[Presentation] 小胞体アミノペプチダーゼ１遺伝子欠損は、セロトニン合成を亢進することで不安を誘発する2019
- Author(s)
  斎藤朱里, 後藤芳邦, 中村孝博, 小川健司, 服部明, 辻本雅文
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07405
[Presentation] 小胞体アミノペプチダーゼ1 遺伝子欠損はセロトニン合成亢進を介して不安障害を惹起する2019
- Author(s)
  小林春奈, 後藤芳邦, 中村孝博, 小川健司, 服部明, 辻本雅文
- Organizer
  日本薬学会　第139年会
- Data Source
  KAKENHI-PROJECT-16K08630
[Presentation] ヒト唾液由来エキソソームの表面分子によるマクロファージ活性化機構の解析2018
- Author(s)
  小川裕子、伊藤芹奈、池本守、粂田奈宝子、後藤芳邦、辻本雅文、秋元義弘、川上速人、矢ノ下良平
- Organizer
  第62回日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-16K08630
[Presentation] ERAP1 遺伝子欠損マウスは精神障害マウスである -行動薬理学的解析-2018
- Author(s)
  滝田万柚子、後藤芳邦、中村孝博、辻本雅文
- Organizer
  第62回日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-16K08630
[Presentation] ERAP1遺伝子欠損マウスは精神障害マウスである2018
- Author(s)
  後藤芳邦
- Organizer
  第62回日本薬学会　関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K08630
[Presentation] ERAP1 遺伝子欠損マウスは精神障害マウスである -脳内セロトニン動態解析-2018
- Author(s)
  金澤徹弥、後藤芳邦、中村孝博、辻本雅文
- Organizer
  第62回日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-16K08630
[Presentation] ERAP1結合型エキソソームによるマクロファージの古典的活性化2017
- Author(s)
  後藤　芳邦、小川　裕子、津元　佑樹、三浦　ゆり、中村　孝博、服部　明、小川　健司、秋元　義弘、川上　速人、遠藤　玉夫、矢ノ下　良平、辻本　雅文
- Organizer
  Conbio2017
- Data Source
  KAKENHI-PROJECT-16K08630
[Presentation] 小胞体アミノペプチダーゼはエンドトキシンショック時に惹起される一酸化窒素合成を亢進する2016
- Author(s)
  後藤芳邦, 小川健司, 中村孝博, 服部明, 辻本雅文
- Organizer
  第89回　日本生化学会大会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K15088
[Presentation] 細菌感染に伴い血中に分泌されたERAP1は血中アミノ酸や一酸化窒素濃度を調節する2015
- Author(s)
  後藤芳邦, 小川健司, 中村孝博, 青嶋瑞樹, 荒俣晃貴, 高田慧, 町田綾乃, 吉野僚太, 服部明, 辻本雅文
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25293083
[Presentation] 細菌感染に伴い血中に分泌されたERAP1は血中アミノ酸や一酸化窒素濃度を調節する2015
- Author(s)
  後藤芳邦, 小川健司, 中村孝博, 青嶋瑞樹, 荒俣晃貴, 高田慧, 町田綾乃, 吉野僚太, 服部明, 辻本雅文
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K15088
[Presentation] 分泌型小胞体アミノペプチダーゼ１によるArg産生を介したマクロファージのNO産生亢進2013
- Author(s)
  後藤芳邦、小川健司、中村孝博、服部　明、辻本雅文
- Organizer
  第18回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター
- Data Source
  KAKENHI-PROJECT-25293083
[Presentation] アミノペプチダーゼBの基質特異性におけるGln169の役割2013
- Author(s)
  小川裕子、大西敦、後藤芳邦、辻本雅文
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659153
[Presentation] マクロファージ古典的活性化に重要なトール様受容体を介した小胞体アミノペプチダーゼの分泌2013
- Author(s)
  後藤芳邦、小川健司、中村孝博、服部　明、辻本雅文
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25293083
[Presentation] マクロファージ古典的活性化に重要なトール様受容体を介した小胞体アミノペプチダーゼの分泌2013
- Author(s)
  後藤芳邦、小川健司、中村孝博、服部明、辻本雅文
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24790083
[Presentation] 分泌型小胞体アミノペプチダーゼによるArg産生を介したマクロファージのNO産生亢進2013
- Author(s)
  後藤芳邦、小川健司、服部明、辻本雅文
- Organizer
  第18回病態プロテアーゼ学会
- Place of Presentation
  千里ライフサイエンスセンター
- Data Source
  KAKENHI-PROJECT-24790083
[Presentation] マクロファージ古典的活性化に重要なトール様受容体を介した小胞体アミノペプチダーゼの分泌2013
- Author(s)
  後藤芳邦、小川健司、中村孝博、服部　明、辻本雅文
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24659153
[Presentation] 分泌型小胞体アミノペプチダーゼ１によるArg産生を介したマクロファージのNO産生亢進2013
- Author(s)
  後藤芳邦、小川健司、中村孝博、服部　明、辻本雅文
- Organizer
  第18回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター
- Data Source
  KAKENHI-PROJECT-24659153
[Presentation] 小胞体アミノペプチダーゼの分泌を介したマクロファージのNO産生亢進2012
- Author(s)
  後藤芳邦, 小川健司, 服部明, 辻本雅文
- Organizer
  第85回　日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24659153
[Presentation] 小胞体アミノペプチダーゼの分泌を介したマクロファージのNO産生亢進2012
- Author(s)
  後藤芳邦, 小川健司, 服部明, 辻本雅文
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場（博多）
- Data Source
  KAKENHI-PROJECT-24790083
[Presentation] Phagocytosis of macrophages is facilitated by secreted ER-aminopeptidase 12010
- Author(s)
  Yoshikuni Goto
- Organizer
  BMB2010
- Place of Presentation
  神戸ポートアイランド(神戸)
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21780103
[Presentation] ERAP-1/A-LAP is secreted form macrophages treated with IFN-γ and LPS2009
- Author(s)
  後藤芳邦
- Organizer
  6^<th> General meeting of International proteolysis society 2009 conference
- Place of Presentation
  Surfers Paradise QD Australia
- Year and Date
  2009-10-28
- Data Source
  KAKENHI-PROJECT-21780103
[Presentation] ERAP-1/A-LAP is secreted form macrophages treated with IFN-γ and LPS2009
- Author(s)
  Yoshikuni Goto
- Organizer
  6th General meeting of International proteolysis society 2009 conference
- Place of Presentation
  Surfers Paradise QD Australia
- Year and Date
  2009-10-28
- Data Source
  KAKENHI-PROJECT-21780103
[Presentation] マクロファージにおけるカルシウムを介した小胞体アミノペプチダーゼ-1の分泌2009
- Author(s)
  後藤芳邦
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(神戸)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21780103
[Presentation] 小胞体アミノペプチダーゼの基質認識機構2009
- Author(s)
  後藤芳邦、丹治弘江、服部明、辻本雅文
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] マクロファージにおける小胞体アミノペプチダーゼ-1の分泌2009
- Author(s)
  後藤芳邦
- Organizer
  第14回病態プロテアーゼ学会
- Place of Presentation
  千里ライフサイエンスセンター(吹田)
- Year and Date
  2009-08-21
- Data Source
  KAKENHI-PROJECT-21780103
[Presentation] マクロファージにおけるカルシウムを介した小胞体アミノペプチダーゼ-1の分泌2009
- Author(s)
  後藤芳邦
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21780103
[Presentation] マクロファージにおける小胞体アミノペプチダーゼ-1の分泌2009
- Author(s)
  後藤芳邦
- Organizer
  第14回病態プロテアーゼ学会
- Place of Presentation
  大阪府吹田市
- Year and Date
  2009-08-21
- Data Source
  KAKENHI-PROJECT-21780103
[Presentation] カルシウムイオンによるアミノペプチダーゼーA活性制御機構の解明2008
- Author(s)
  後藤芳邦
- Organizer
  日本薬学会128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] カルシウムイオンによるアミノペプチダーゼ-A活性制御機構の解明2008
- Author(s)
  後藤芳邦、服部明、辻本雅文
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] 脂肪細胞由来ロイシンアミノペプチダーゼのGln-181残基は基質特異性に重要である2008
- Author(s)
  後藤芳邦
- Organizer
  第13回病態と治療におけるプロテアーゼとインヒビター学会
- Place of Presentation
  吹田/大阪
- Year and Date
  2008-08-22
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] ヒト脂肪細胞由来ロイシンアミノペプチダーゼのGln-181残基は基質特異性に重要である2008
- Author(s)
  後藤芳邦、丹治弘江、服部明、辻本雅文
- Organizer
  第31回日本分子生物学会年会/第81回日本生化学会大会 (BMB2008)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] 脂肪細胞由来ロイシンアミノペプチダーゼのGln-181残基は基質特異性に重要である2008
- Author(s)
  後藤芳邦
- Organizer
  第31回日本分子生物学会年会/第81回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] Asp-221 plays an essential role in the calcium-dependent regulatory mechanism of human aminopeptidase A2007
- Author(s)
  Goto, Y., Hattori, A. Mizutani, S. and Tsujimoto, M.
- Organizer
  5th General Meeting of the International Proteolysis Society
- Place of Presentation
  Patras, Greece
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] ヒトアミノペプチダーゼAのAsp221残基はカルシウムによる活性制御に必須である2007
- Author(s)
  後藤芳邦
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] アミノペプチダーゼAのAsp-221残基はカルシウムとの相互作用に必須である2007
- Author(s)
  後藤芳邦
- Organizer
  第12回病態と治療におけるプロテアーゼとインヒビター研究会
- Place of Presentation
  大阪
- Year and Date
  2007-08-03
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] Laeverin/aminopeptidase Q: a novel bestatin sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases2007
- Author(s)
  Maruyama, M., Hattori, A, Goto, Y. Ueda, M. Maeda, M. Fujiwara, H. and Tsujimoto, M.
- Organizer
  5th General Meeting of the International Proteolysis Society
- Place of Presentation
  Patras, Greece
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] ヒトアミノペプチダーゼAのAsp221残基はカルシウムによる活性制御に必須である2007
- Author(s)
  後藤芳邦、服部明、辻本雅文
- Organizer
  第30回日本分子生物学会年会/第80回日本生化学会大会 (BMB2007)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] 新規アミノペプチダーゼLaeverinの酵素学的性状の解析2007
- Author(s)
  丸山正人、服部明、後藤芳邦、藤原浩、辻本雅文
- Organizer
  第12回病態と治療におけるプロテアーゼとインヒビター研究会
- Place of Presentation
  吹田
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] アミノペプチダーゼAのAsp-221残基はカルシウムとの相互作用に必須である2007
- Author(s)
  後藤芳邦、服部明、辻本雅文
- Organizer
  第12回病態と治療におけるプロテアーゼとインヒビター研究会
- Place of Presentation
  吹田
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] Asp-221 plays an essential role in the calcium-dependent regulatory mechanism of human aminopeptidase A2007
- Author(s)
  Yoshikuni Goto
- Organizer
  5th General meeting of the international proteolysis society
- Place of Presentation
  ギリシャ
- Year and Date
  2007-10-23
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] Characterization of recombinant human aminopeptidase A expressed in a baculovirus system2006
- Author(s)
  Goto, Y., Hattori, M., Ishii, Y., Mizutani, S. and Tsujimoto, M.
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] アミノペプチダーゼAの酵素活性はCa^<2+>とAngIVによって制御される2006
- Author(s)
  後藤芳邦、服部明、辻本雅文
- Organizer
  第50回日本薬学会関東支部大会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] ヒト唾液エキソソームによるマクロファージの活性化
- Author(s)
  小川（池本）裕子, 粂田奈宝子, 後藤芳邦, 池本守, 辻本雅文, 矢ノ下良平
- Organizer
  第87回日本生化学会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25460172
[Presentation] 小胞体アミノペプチダーゼ1遺伝子欠損に伴うマクロファージのFcγ受容体依存性貪食活性の低下
- Author(s)
  後藤芳邦、小川健司、中村孝博、服部明、辻本雅文
- Organizer
  第87回　日本生化学会大会
- Place of Presentation
  京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25293083
[Presentation] 小胞体アミノペプチダーゼ1遺伝子欠損に伴うマクロファージのFcγ受容体依存性貪食活性の低下
- Author(s)
  後藤芳邦, 小川健司, 中村孝博, 服部明, 辻本雅文
- Organizer
  第87回　日本生化学会大会
- Place of Presentation
  京都国際会議場（京都府京都市）
- Year and Date
  2014-10-16 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24790083
[Presentation] 小胞体アミノペプチダーゼ1遺伝子欠損に伴うマクロファージのFcγ受容体依存性貪食活性の低下
- Author(s)
  後藤芳邦、小川健司、中村孝博、服部明、辻本雅文
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24659153

1. TSUJIMOTO Masafumi (00281668)

# of Collaborated Projects: 5 results

# of Collaborated Products: 32 results
2. HATTORI Akira (50300893)

# of Collaborated Projects: 4 results

# of Collaborated Products: 32 results
3. OGAWA Yuko (30267330)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. MARUYAMA Masato (00399445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. TAKASU Kiyosei (10302168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OGAWA Kenji (50251418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. YANOSHITA Ryohei (90267336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. NAKAMURA Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Goto Yoshikuni 後藤 芳邦

GOTO Yoshikuni 後藤 芳邦

Research Projects

Research Products

Co-Researchers

MHCクラスI抗原提示の機能不全が惹起する脳内セロトニン過剰疾患「不安障害」Principal Investigator

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Dysfunction of ERAP1 induces anxiety disorder via excess serotonin synthesisPrincipal Investigator

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Roles of ER aminopeptidase 1 in inflammation of Behcet's diseasePrincipal Investigator

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Role of ERAP1 in the pathogenesis of mental disorders

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Pathophysiological roles of M1 aminopeptidases

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Molecular mechanism and regulation of immune activation cascade by aminopeptidase contained exosome.

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Role of aminopeptidases in atherosclerosis

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Contribution of ER-aminopeptidase secretion to classical activation of macrophagesPrincipal Investigator

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Regulation of blood pressure by secreted adipocyte-derived leucine aminopeptidasePrincipal Investigator

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Mechanisms of Enzymatic Action of the Oxytocinase Subfamily of Aminopeptidases

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[Journal Article] Diurnal variations of triglyceride accumulation in mouse and bovine adipocyte‐derived cell lines2022

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[Journal Article] Stability of human salivary extracellular vesicles containing dipeptidyl peptidase IV under simulated gastrointestinal tract conditions2021

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[Journal Article] Molecular and functional diversity of the oxytocinase subfamily of M1 aminopeptidases2021

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DOI

NAID

Goto Yoshikuni 後藤芳邦

GOTO Yoshikuni 後藤芳邦