Mizobuchi Masahide 溝渕正英

… Alternative Names

MIZOBUCHI MASAHIDE 溝渕正英

MIZOBUCHI Masahide 溝渕正英

Less

Researcher Number	90465203
Other IDs	https://orcid.org/0000-0002-6117-8414
Affiliation (Current)	2025: 昭和大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 昭和大学, 医学部, 准教授 2017 – 2019: 昭和大学, 医学部, 講師 2012 – 2015: 昭和大学, 医学部, 講師 2008 – 2011: Showa University, 医学部, 助教 2009: Showa University, 医学部・内科学講座腎臓内科学部門, 助教
Review Section/Research Field	Principal Investigator Kidney internal medicine / Basic Section 53040:Nephrology-related Except Principal Investigator Kidney internal medicine / Basic Section 53040:Nephrology-related
Keywords	Principal Investigator 血管石灰化 / 炎症 / 骨格筋 / 分化 / 筋芽細胞 / FGF23 / CKD-MBD / ビタミンD / 内皮細胞 / VDR … More / カルシトリオール / アポトーシス / TRPV / Ca / TRPVチャネル / カルシウム / 血管平滑筋細胞 / 心血管病変 / 血管リモデリング / 活性型ビタミンD / 動脈硬化 / 慢性腎臓病 / MMP-2 / エラスチン分解 / カルシウム感知受容体 / グリアルセルミッシング2 / ビタミンD受容体 / Ca感知受容体 / 副甲状腺細胞 / Gcm2 / 二次性副甲状腺機能亢進症 … More Except Principal Investigator CKD-MBD / 尿毒症 / FGF-23 / 心筋線維化 / 心血管障害 / 尿毒勝 / ビタミンD受容体 / ビタミンD / 骨・ミネラル代謝 / 腎臓内科学 / 内科 / 間葉系幹細胞 / 骨芽細胞 / ミネラル代謝 / 腎不全 / 骨代謝 / iPS細胞 / 副甲状腺ホルモン / 線維性骨炎 / bisphosphonate / カルシウム受容作動薬 / 動脈硬化 / 慢性腎不全 / エラスチン / 慢性炎症 / 異所性石灰化 / 腎性骨異栄養症 / 二次性副甲状腺機能亢進症 / 慢性腎臓病ミネラル骨代謝異常症 Less

CKDのリン代謝異常による新規臓器毒性の探究Principal Investigator
- Principal Investigator
  
  溝渕正英
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Showa University
Elucidation of Regulatory Mechanism of Vitamin D- Vitamin D Receptor System in Cardiovascular Tissues in Uremic Milieu
- Principal Investigator
  
  OGATA HIROAKI
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Showa University
Vascular health and vitamin D under uremic conditionPrincipal Investigator
- Principal Investigator
  
  MIZOBUCHI MASAHIDE
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Showa University
Establishment of Pathological Model of Skeletal resistance to PTH in Uremia using iPS Cells
- Principal Investigator
  
  OGATA HIROAKI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Showa University
Ca Load Induces Vascular Smooth Muscle Cell Mineralization Partly Mediated by TRPVPrincipal Investigator
- Principal Investigator
  
  MIZOBUCHI MASAHIDE
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Showa University
Role of elastin degradation in the process of vascular calcification in uremic milieuPrincipal Investigator
- Principal Investigator
  
  MIZOBUCHI Masahide
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Showa University
Experimental study for the regression of chronic kidney disease and mineral bone disorder(CKD-MBD)
- Principal Investigator
  
  AKIZAWA Tadao
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Showa University
Calcium-sensing receptor expression is regulated by glial cells missing-2 in human parathyroid cellsPrincipal Investigator
- Principal Investigator
  
  MIZOBUCHI Masahide
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Showa University

All 2023 2019 2018 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Fibroblast Growth Factor 23 Exacerbates Cardiac Fibrosis in Deoxycorticosterone Acetate-Salt Mice With Hypertension2023
- Author(s)
  Saito Tomohiro、Mizobuchi Masahide、Kato Tadashi、Ogata Hiroaki、Koiwa Fumihiko、Honda Hirokazu
- Journal Title
  
  Laboratory Investigation
  
  Volume: 103 Issue: 1 Pages: 100003-100003
- DOI
  10.1016/j.labinv.2022.100003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08598
[Journal Article] Effect of Continuous Intravenous Calcium Loading on Fibroblast Growth Factor 23 in Normal and Uremic Rats2018
- Author(s)
  Shikida Yasuto、Mizobuchi Masahide、Inoue Takashi、Hamada Toma、Ogata Hiroaki、Koiwa Fumihiko、Shibata Takanori
- Journal Title
  
  Calcified Tissue International
  
  Volume: 103 Issue: 4 Pages: 455-464
- DOI
  10.1007/s00223-018-0440-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09737
[Journal Article] Secondary Hyperparathyroidism: Pathogenesis and Latest Treatment2018
- Author(s)
  Mizobuchi Masahide、Ogata Hiroaki、Koiwa Fumihiko
- Journal Title
  
  Therapeutic Apheresis and Dialysis
  
  Volume: online first Issue: 4 Pages: 309-318
- DOI
  10.1111/1744-9987.12772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09737
[Journal Article] Vitamin D receptor activators inhibit vascular smooth muscle cell mineralization induced by phosphate and TNF-α2012
- Author(s)
  Aoshima Y, Mizobuchi M, Ogata H, Kumata C, Nakazawa A, Kondo F, Ono N, Koiwa F, Kinugasa E, Akizawa T
- Journal Title
  
  Nephrol Dial Transplant
  
  Volume: 27 Pages: 1800-1806
- Data Source
  KAKENHI-PROJECT-22790806
[Journal Article] Vitamin D receptor acivators inhibit vascular smooth muscle cell mineralizaton induced by phosphate and TNF-α2012
- Author(s)
  Aoshima Y, Mizobuchi M, et al
- Journal Title
  
  Nephrology Dialysis Transplantation
  
  Volume: 27 Pages: 1800-1806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790806
[Journal Article] Involvement of matrix metalloproteinase-2 in the development of medial layer vascular calcification in uremic rats2011
- Author(s)
  Kumata C, Mizobuchi M, Ogata H, Koiwa F, Kondo F, Kinugasa E, Akizawa T
- Journal Title
  
  Ther Apher Dial 15 Suppl
  
  Volume: 1 Pages: 18-22
- Data Source
  KAKENHI-PROJECT-22790806
[Journal Article] Involvement of alpha-klotho and fibroblast growth factor receptor in the development of secondary hyperparathyroidism.2010
- Author(s)
  Kumata C, Mizobuchi M, Ogata H, Koiwa F, Nakazawa A, Kondo F, Kadokura Y, Kinugasa E, Akizawa T
- Journal Title
  
  Am J Nephrol. 31(3)
  
  Pages: 230-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590985
[Journal Article] Myocardial effects of VDR activators in renal failure.2010
- Author(s)
  Mizobuchi M, Nakamura H, Tokumoto M, Finch J, Morrissey J, Liapis H, Slatopolsky E
- Journal Title
  
  J Steroid Biochem Mol Biol. 121(1-2)
  
  Pages: 188-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590985
[Journal Article] Detection of peripheral artery disease by duplex ultrasonography among hemodialysis patients.2010
- Author(s)
  Ogata H, Kumata-Maeta C, Shishido K, Mizobuchi M, Yamamoto M, Koiwa F, Kinugasa E, Akizawa T
- Journal Title
  
  Clin J Am Soc Nephrol. 5(12)
  
  Pages: 2199-206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590985
[Journal Article] Novel markers of left ventricular hypertrophy in uremia.2010
- Author(s)
  Nakamura H, Tokumoto M, Mizobuchi M, Ritter CS, Finch JL, Mukai M, Slatopolsky E
- Journal Title
  
  Am J Nephrol. 31(4)
  
  Pages: 292-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590985
[Journal Article] Vitamin D and vascular calcification in chronic kidney disease2009
- Author(s)
  Mizobuchi M
- Journal Title
  
  Bone 45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590985
[Journal Article] Vitamin D and vascular calcification in chronic kidney disease.2009
- Author(s)
  Mizobuchi M, Ogata H, Koiwa F, Kinugasa E, Akizawa T
- Journal Title
  
  Bone. 45 Suppl 1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590985
[Journal Article] Calcium-sensing receptor expression is regulated by glial cells missing-2 in human parathyroid cells.2009
- Author(s)
  Mizobuchi M, et al.
- Journal Title
  
  J Bone Miner Res. 24
  
  Pages: 1173-1179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790598
[Journal Article] Vascular calcification : the killer of patients with chronic kidney disease.2009
- Author(s)
  Mizobuchi M, Towler D, Slatopolsky E
- Journal Title
  
  J Am Soc Nephrol. 20(7)
  
  Pages: 1453-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590985
[Journal Article] Calcium-sensing receptor expression is regulated by glial cells missing-2 in human parathyroid cells2009
- Author(s)
  Mizobuchi M, Ritter CS, Kris I, Slatopolsky E, Sicard G, Brown AJ
- Journal Title
  
  J Bone Miner Res 24
  
  Pages: 1173-1179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790598
[Journal Article] Calcium-sensing receptor expression is regulated by glial cells missing-2 in human parathyroid cells.2009
- Author(s)
  Mizobuchi M, Ritter CS, Krits I, Slatopolsky E, Sicard G, Brown AJ
- Journal Title
  
  J Bone Miner Res. 24(7)
  
  Pages: 1173-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590985
[Journal Article] Combination therapy with paricalcitol and enalapril ameliorates cardiac oxidative injury in uremic rats.2009
- Author(s)
  Husain K, Ferder L, Mizobuchi M, Finch J, Slatopolsky E
- Journal Title
  
  Am J Nephrol. 29(5)
  
  Pages: 465-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590985
[Journal Article] Elastin degradation accelerates phosphate-induced mineralization of vascular smooth muscle cells.2009
- Author(s)
  Hosaka N, Mizobuchi M, Ogata H, Kumata C, Kondo F, Koiwa F, Kinugasa E, Akizawa T
- Journal Title
  
  Calcif Tissue Int. 85(6)
  
  Pages: 523-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590985
[Journal Article] Blockage of the renin-angiotensin system attenuates mortality but not vascular calcification in uremic rats : sevelamer carbonate prevents vascular calcification.2009
- Author(s)
  Tokumoto M, Mizobuchi M, Finch JL, Nakamura H, Martin DR, Slatopolsky E
- Journal Title
  
  Am J Nephrol. 29(6)
  
  Pages: 582-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590985
[Journal Article] Involvement of Matrix Metalloproteinase-2 in the Development of Medial layer Vascular Calcification in Uremic Rats
- Author(s)
  Kumata C, Mizobuchi M, et al.
- Journal Title
  
  Ther Apher Dial
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790806
[Journal Article] Involvement of Matrix Metalloproteinase-2 in the Development of Medial Layer Vascular Calcification in Uremic Rats.
- Author(s)
  Chiaki Kumata, 1 Masahide Mizobuchi, Hiroaki Ogata, Fumihiko Koiwa, Fumiko Kondo, Eriko Kinugasa, Tadao Akizawa
- Journal Title
  
  Ther Apher Dial. 15(Supplement 1)
  
  Pages: 18-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590985
[Presentation] 腎不全ラットの骨髄由来間葉系幹細胞におけるリン負荷の影響2019
- Author(s)
  加藤憲,溝渕正英,朝倉慶,和田紗矢香,山本真寛,伊藤英利,上條竜太郎,緒方浩顕
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09737
[Presentation] Osteoblastic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Uremic Rats with Secondary Hyperparathyroidism2018
- Author(s)
  Kato K, Mizobuchi M, Ogata H
- Organizer
  Kidney Week 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09737
[Presentation] Vitamin D receptor activators inhibit vascular smooth muscle cell mineralization induced by phosphate and TNF-α2012
- Author(s)
  Aoshima Y,Mizobuchi M,Ogata H,Kumata C,Nakazawa A,Kondo F,Ono N,Koiwa F,Kinugasa E,Akizawa T
- Organizer
  49th ERA-EDTA Congress
- Place of Presentation
  Paris
- Data Source
  KAKENHI-PROJECT-22790806
[Presentation] A vitamin D analog inhibits VSMC mineralization induced by TNF-α and phosphate2010
- Author(s)
  Aoshima Y,Mizobuchi M,Kumata C,Nakazawa A,Kondo F,Ono N,Ogata H,Kinugasa E,Akizawa T
- Organizer
  American Society for Nephrology Kidney Week 2010
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22790806
[Presentation] Involvement of matrix metalloproteinase-2 in the development of aortic calcification in uremic rats2010
- Author(s)
  溝渕正英
- Organizer
  ISN-NUXUS KYOTO
- Place of Presentation
  京都
- Year and Date
  2010-04-17
- Data Source
  KAKENHI-PROJECT-22790806
[Presentation] Involvement of matrix metalloproteinase-2 in the development of medial layer vascular calcification in uremic rats2010
- Author(s)
  Kumata C,Mizobuchi M,Ogata H,Koiwa F,Kondo F,Kinugasa E,Akizawa T
- Organizer
  American Society for Nephrology Kidney Week 2010
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22790806
[Presentation] Involvement of matrix metalloproteinase-2 in the development of medial layer vascular calcification in uremic rats2010
- Author(s)
  Kumata C,Mizobuchi M,Ogata H,Koiwa F,Kondo F,Kinugasa E,Akizawa T
- Organizer
  NEXUS Symposium Kyoto
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22790806
[Presentation] Effect of elastin degradation on the mineralization of vascular smooth muscle cells2008
- Author(s)
  Hosaka N, Mizobuchi M, Akizawa T, et. al
- Organizer
  米国腎臓学会
- Place of Presentation
  Philadelphia
- Year and Date
  2008-11-07
- Data Source
  KAKENHI-PROJECT-20590985
[Presentation] Effect of elastin degradation on the mineralization of vascular smooth muscle cells2008
- Author(s)
  Hasaka N, Mizobuchi M, et.al.
- Organizer
  米国腎臓学会
- Place of Presentation
  フィラデルフィア
- Year and Date
  2008-11-07
- Data Source
  KAKENHI-PROJECT-20790598
[Presentation] Regulation of calcium-sensing receptor by glial cells missing 2 in hyperplastic parathyroid cells2007
- Author(s)
  溝渕正英
- Organizer
  第42回米国腎臓学会
- Place of Presentation
  サンフランシスコ
- Year and Date
  2007-11-03
- Data Source
  KAKENHI-PROJECT-20790598
[Presentation] Regulation of calcium-sensing receptor by glial cells missing 2 in hyperplastic parathyroid cells2007
- Author(s)
  溝渕正英
- Organizer
  第29回米国骨代謝学会義
- Place of Presentation
  ホノルル
- Year and Date
  2007-09-18
- Data Source
  KAKENHI-PROJECT-20790598
[Presentation] Ca Load Induces Vascular Smooth Muscle Cell Mineralization Partly Mediated by TRPV
- Author(s)
  溝渕正英
- Organizer
  米国腎臓学会議
- Place of Presentation
  フィラデルフィア
- Year and Date
  2014-11-11 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-25461255

1. OGATA Hiroaki (30296959)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
2. AKIZAWA Tadao (40102339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 加藤憲 (20644305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 秋沢忠男

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results

Mizobuchi Masahide 溝渕 正英

MIZOBUCHI MASAHIDE 溝渕 正英

MIZOBUCHI Masahide 溝渕 正英

Research Projects

Research Products

Co-Researchers

CKDのリン代謝異常による新規臓器毒性の探究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of Regulatory Mechanism of Vitamin D- Vitamin D Receptor System in Cardiovascular Tissues in Uremic Milieu

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Vascular health and vitamin D under uremic conditionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of Pathological Model of Skeletal resistance to PTH in Uremia using iPS Cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ca Load Induces Vascular Smooth Muscle Cell Mineralization Partly Mediated by TRPVPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of elastin degradation in the process of vascular calcification in uremic milieuPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental study for the regression of chronic kidney disease and mineral bone disorder(CKD-MBD)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Calcium-sensing receptor expression is regulated by glial cells missing-2 in human parathyroid cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Fibroblast Growth Factor 23 Exacerbates Cardiac Fibrosis in Deoxycorticosterone Acetate-Salt Mice With Hypertension2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of Continuous Intravenous Calcium Loading on Fibroblast Growth Factor 23 in Normal and Uremic Rats2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Secondary Hyperparathyroidism: Pathogenesis and Latest Treatment2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vitamin D receptor activators inhibit vascular smooth muscle cell mineralization induced by phosphate and TNF-α2012

Author(s)

Journal Title

Data Source

[Journal Article] Vitamin D receptor acivators inhibit vascular smooth muscle cell mineralizaton induced by phosphate and TNF-α2012

Author(s)

Journal Title

Data Source

[Journal Article] Involvement of matrix metalloproteinase-2 in the development of medial layer vascular calcification in uremic rats2011

Author(s)

Journal Title

Mizobuchi Masahide 溝渕正英

MIZOBUCHI MASAHIDE 溝渕正英

MIZOBUCHI Masahide 溝渕正英