Imashimizu Masahiko 今清水正彦

Researcher Number	90465930
Affiliation (Current)	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 上級主任研究員
Affiliation (based on the past Project Information) *help	2020 – 2024: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 2018 – 2020: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 2016 – 2017: 東京大学, 医科学研究所, 特任講師
Review Section/Research Field	Principal Investigator Science and Engineering / Basic Section 43040:Biophysics-related / Basic Section 45010:Genetics-related / Medium-sized Section 13:Condensed matter physics and related fields / Biomolecular chemistry
Keywords	Principal Investigator 水和 / サブテラヘルツ / テラヘルツ / 誘電緩和 / RNAポリメラーゼ / 熱揺らぎ / ハイスループットDNAシーケンシング / 熱ゆらぎ / 誘電分光 / 不均一性 … More / dielectric relaxation / RNA polymerase / hydration / fidelity / sub-THz / 水素結合ダイナミクス / アボーティブ転写 / ポージング / 転写開始 / 遺伝情報 / 転写調節 / テラヘルツ光 / 反復DNA配列 / 水 / 反復パターン / 水素結合 / 溶液NMR / 水素結合ネットワーク / イミノプロトン / 反復配列 / 転写因子 / DNA / resonance / ハイスループットシーケンシング / 転写複合体 / 非熱的効果 / 不均質性 / 生物ナノマシン / 酵素反応正確性 / テラヘルツ波 / ナノバイオ / 医薬 / 核酸 / 核酸創薬 / ハイスループットシーケンス / RNA アプタマー / ハイスループット法 / 構造不均一性 / 結合アフィニティー / 核酸ータンパク質相互作用 / RNAアプタマー Less

Contribution of hydration in transcription fidelity: Understanding the molecular basis and its regulation by subterahertz waves.Principal Investigator
- Principal Investigator
  
  今清水正彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Understanding biological functions based on the heterogeneity of hydration water dynamicsPrincipal Investigator
- Principal Investigator
  
  今清水正彦
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Revisiting genetic information: introducing the concept of the collective dynamics of DNA and waterPrincipal Investigator
- Principal Investigator
  
  Imashimizu Masahiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 45010:Genetics-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Detection and control of functional vibrations of biomolecular machines by resonance phenomenaPrincipal Investigator
- Principal Investigator
  
  Masahiko Imashimizu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 13:Condensed matter physics and related fields
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Molecular Design of RNA aptamersPrincipal Investigator
- Principal Investigator
  
  Imashimizu Masahiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biomolecular chemistry
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] Nonthermal acceleration of protein hydration by sub-terahertz irradiation2023
- Author(s)
  Sugiyama Jun-ichi、Tokunaga Yuji、Hishida Mafumi、Tanaka Masahito、Takeuchi Koh、Satoh Daisuke、Imashimizu Masahiko
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 2825-2825
- DOI
  10.1038/s41467-023-38462-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18374, KAKENHI-PLANNED-19H05717, KAKENHI-PUBLICLY-22H04566, KAKENHI-PROJECT-23K27310, KAKENHI-PROJECT-20H03298
[Journal Article] Repetitive DNA symmetry elements negatively regulate gene expression in embryonic stem cells2022
- Author(s)
  Mellul Meir、Lahav Shlomtzion、Imashimizu Masahiko、Tokunaga Yuji、Lukatsky David B.、Ram Oren
- Journal Title
  
  Biophysical Journal
  
  Volume: 121 Issue: 16 Pages: 3126-3135
- DOI
  10.1016/j.bpj.2022.07.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03298
[Journal Article] Nonthermal excitation effects mediated by subterahertz radiation on hydrogen exchange in ubiquitin2021
- Author(s)
  Tokunaga Yuji、Tanaka Masahito、Iida Hitoshi、Kinoshita Moto、Tojima Yuya、Takeuchi Koh、Imashimizu Masahiko
- Journal Title
  
  Biophysical Journal
  
  Volume: 120 Issue: 12 Pages: 1-8
- DOI
  10.1016/j.bpj.2021.04.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18731, KAKENHI-PROJECT-18H02393, KAKENHI-PROJECT-20H03298
[Journal Article] Control of Transcription Initiation by Biased Thermal Fluctuations on Repetitive Genomic Sequences2020
- Author(s)
  Imashimizu Masahiko、Tokunaga Yuji、Afek Ariel、Takahashi Hiroki、Shimamoto Nobuo、Lukatsky David B.
- Journal Title
  
  Biomolecules
  
  Volume: 10 Issue: 9 Pages: 1299-1299
- DOI
  10.3390/biom10091299
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18731, KAKENHI-PROJECT-20H03298
[Journal Article] RNA Polymerase and Transcription Mechanisms: The Forefront of Physicochemical Studies of Chemical Reactions2020
- Author(s)
  Shimamoto Nobuo、Imashimizu Masahiko
- Journal Title
  
  Biomolecules
  
  Volume: 11 Issue: 1 Pages: 32-32
- DOI
  10.3390/biom11010032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03298
[Journal Article] Gre factors prevent thermal and mechanical stresses induced by terahertz irradiation during transcription2020
- Author(s)
  Imashimizu Masahiko、Tanaka Masahito、Hoshina Hiromichi
- Journal Title
  
  Genes to Cells
  
  Volume: 26 Issue: 2 Pages: 56-64
- DOI
  10.1111/gtc.12822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18731, KAKENHI-PROJECT-20H03298
[Journal Article] Transcription Factor Binding in Embryonic Stem Cells Is Constrained by DNA Sequence Repeat Symmetry2020
- Author(s)
  Goldshtein Matan、Mellul Meir、Deutch Gai、Imashimizu Masahiko、Takeuchi Koh、Meshorer Eran、Ram Oren、Lukatsky David B.
- Journal Title
  
  Biophysical Journal
  
  Volume: 118 Issue: 8 Pages: 2015-2026
- DOI
  10.1016/j.bpj.2020.02.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03298
[Journal Article] The role of pyrophosphorolysis in the initiation-to-elongation transition by E. coli RNA polymerase2019
- Author(s)
  Masahiko Imashimizu, Maria L. Kireeva, Lucyna Lubkowska, Mikhail Kashlev and NobuoShimamoto
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: - Issue: 14 Pages: 2528-2542
- DOI
  10.1016/j.jmb.2019.04.020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18731
[Journal Article] Single-round isolation of diverse RNA aptamers from a random sequence pool2018
- Author(s)
  Imashimizu Masahiko, Takahashi Masaki, Amano Ryo and Nakamura Yoshikazu
- Journal Title
  
  Biology Methods and Protocols
  
  Volume: ー Issue: 1
- DOI
  10.1093/biomethods/bpy004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06692
[Journal Article] Transcription pausing: biological significance of thermal fluctuations biased by repetitive genomic sequences2018
- Author(s)
  Imashimizu Masahiko、Lukatsky David B.
- Journal Title
  
  Transcription
  
  Volume: Vol. 9, No 3 Issue: 3 Pages: 196-203
- DOI
  10.1080/21541264.2017.1393492
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06692
[Journal Article] Control of transcriptional pausing by biased thermal fluctuations on repetitive genomic sequences2016
- Author(s)
  Masahiko Imashimizu, Ariel Afek, Hiroki Takahashi, Lucyna Lubkowska, and David B. Lukatsky
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 113(47) Issue: 47
- DOI
  10.1073/pnas.1607760113
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06692, KAKENHI-PROJECT-16K18671, KAKENHI-PROJECT-16H06279
[Patent] 液体の水素結合構造変化の検出方法及び検出装置2023
- Inventor(s)
  今清水正彦, 杉山順一, 田中真人
- Industrial Property Rights Holder
  国立研究開発法人産業技術総合研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-138356
- Filing Date
  2023
- Data Source
  KAKENHI-PUBLICLY-22H04566
[Presentation] 水和による水の不均一性から生物機能を理解する2023
- Author(s)
  今清水正彦
- Organizer
  第13回CSJ化学フェスタ2023
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04566
[Presentation] Nonthermal Effect of Sub-THz Irradiation on Protein Hydration: Study Based on Dielectric Relaxation Measurements2023
- Author(s)
  今清水正彦, 杉山順一, 田中真人
- Organizer
  第61回日本生物物理学会年会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04566
[Presentation] Nonthermal acceleration of protein hydration by sub-terahertz irradiation2023
- Author(s)
  今清水正彦
- Organizer
  Bioelectrodynamics webinar series (Online)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04566
[Presentation] Nonthermal acceleration of protein hydration by sub-terahertz irradiation: Analysis of dielectric relaxation measurements2022
- Author(s)
  今清水正彦、杉山順一、田中真人
- Organizer
  日本生物物理学会第60回年会
- Data Source
  KAKENHI-PUBLICLY-22H04566
[Presentation] テラバイオロジー：遺伝子型への変異の代わりに水素結合網へのTHz照射を摂動として用いる2022
- Author(s)
  今清水正彦、杉山順一、田中真人
- Organizer
  第４５回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-22H04566
[Presentation] サブテラヘルツ波照射によるタンパク質水和の非熱的促進2022
- Author(s)
  今清水正彦、杉山順一、田中真人
- Organizer
  日本分析化学会第71回年会
- Data Source
  KAKENHI-PUBLICLY-22H04566
[Presentation] サブテラヘルツ波照射によるタンパク質水和の非熱的促進2022
- Author(s)
  今清水正彦、杉山順一、田中真人
- Organizer
  日本分析化学会第71回年会
- Data Source
  KAKENHI-PROJECT-20H03298
[Presentation] 水溶液へのサブテラヘルツ波照射作用2022
- Author(s)
  今清水正彦、河野誠、杉山順一、小川博嗣、田中真人
- Organizer
  日本分析化学会第71回年会
- Data Source
  KAKENHI-PUBLICLY-22H04566
[Presentation] 水溶液へのサブテラヘルツ波照射作用2022
- Author(s)
  今清水正彦、河野誠、杉山順一、小川博嗣、田中真人
- Organizer
  日本分析化学会第71回年会
- Data Source
  KAKENHI-PROJECT-20H03298
[Presentation] テラバイオロジー：遺伝子型への変異の代わりに水素結合網へのTHz照射を摂動として用いる2022
- Author(s)
  今清水正彦、杉山順一、田中真人
- Organizer
  第４５回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03298
[Presentation] Nonthermal acceleration of protein hydration by sub-terahertz irradiation: Analysis of dielectric relaxation measurements2022
- Author(s)
  今清水正彦、杉山順一、田中真人
- Organizer
  日本生物物理学会第60回年会
- Data Source
  KAKENHI-PROJECT-20H03298
[Presentation] 生体高分子水溶液への非熱的0.1THz励起作用2021
- Author(s)
  今清水正彦、杉山順一、田中真人、徳永裕二
- Organizer
  第15回日本電磁波エネルギー応用学会シンポジウム
- Data Source
  KAKENHI-PROJECT-20H03298
[Presentation] ポリメラーゼ反応へのTHz波照射作用とsub-THz波照射作用2021
- Author(s)
  今清水正彦
- Organizer
  公開シンポジウム「量子ビームで創る新しい生命科学:X線からテラヘルツまで」
- Invited
- Data Source
  KAKENHI-PROJECT-20H03298
[Presentation] Nonthermal Excitation Effects Mediated by Sub-Terahertz Radiation on Biomolecular Hydration Dynamics and Reactions.2021
- Author(s)
  今清水正彦、徳永裕二、田中真人、杉山順一
- Organizer
  第59回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03298
[Presentation] テラバイオロジー:テラヘルツ領域の分子運動から生物機能を理解する2020
- Author(s)
  今清水正彦、徳永裕二、田中真人、竹内恒、保科宏道
- Organizer
  第10回超異分野学会本大会
- Data Source
  KAKENHI-PROJECT-18K18731
[Presentation] テラバイオロジーとテラバイオテクノロジーの創出2020
- Author(s)
  今清水正彦、田中真人、杉山順一、保科宏道、竹内恒
- Organizer
  超異分野学会関西フォーラム 2020
- Data Source
  KAKENHI-PROJECT-20H03298
[Presentation] 遺伝情報とDNAの物性をつなげる:DNAと水の水素結合ダイナミクスから見た転写調節機能2020
- Author(s)
  今清水正彦、徳永裕二、田中真人、高橋弘喜
- Organizer
  第92回日本遺伝学会(現地開催中止)
- Data Source
  KAKENHI-PROJECT-18K18731
[Presentation] 遺伝情報とDNAの物性をつなげる：DNAと水の水素結合ダイナミクスから見た転写調節機能2020
- Author(s)
  今清水正彦、徳永裕二、田中真人、高橋弘喜
- Organizer
  第92回日本遺伝学会大会
- Data Source
  KAKENHI-PROJECT-20H03298
[Presentation] Efects of Nonthermal Excitation Mediated by Terahertz Radiation on Biomolecular Dynamics and Reactions2020
- Author(s)
  今清水正彦、徳永裕二、竹内恒、田中真人、保科宏道、山口裕資
- Organizer
  The 8th International Workshop on Far-Infrared Technologies (IW-FIRT2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18731
[Presentation] テラバイオロジー：テラヘルツ領域の分子運動から生物機能を理解する2020
- Author(s)
  今清水正彦、徳永裕二、田中真人、保科宏道、竹内恒
- Organizer
  第10回超異分野学会本大会
- Data Source
  KAKENHI-PROJECT-20H03298
[Presentation] テラバイオロジーとテラバイオテクノロジーの創出2020
- Author(s)
  今清水正彦、田中真人、杉山順一、保科宏道、竹内恒
- Organizer
  超異分野学会関西フォーラム 2020
- Data Source
  KAKENHI-PROJECT-18K18731
[Presentation] Effects of Nonthermal Excitation Mediated by Terahertz Radiation on Biomolecular Dynamics and Reactions2020
- Author(s)
  今清水正彦、徳永裕二、田中真人、保科宏道、山口裕資、竹内恒
- Organizer
  The 8th International Workshop on Far-Infrared Technologies (IW-FIRT 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03298
[Presentation] テラヘルツ光照射が生化学反応に及ぼす影響:転写をモデルとした研究2019
- Author(s)
  今清水正彦, 田中真人, 田上俊輔, 保科宏道, 竹内恒
- Organizer
  第13回日本電磁波エネルギー応用学会シンポジウム
- Data Source
  KAKENHI-PROJECT-18K18731
[Presentation] Terahertz wave irradiation and temperature increase differently affect transcription by RNA polymerase.2019
- Author(s)
  今清水正彦, 田中真人, 保科宏道, 竹内恒
- Organizer
  第57回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-18K18731
[Presentation] Understanding of biomolecular functions that utilize thermal fluctuations.2019
- Author(s)
  今清水正彦
- Organizer
  Mini-Symposium "Biophysics of Genome"，Ben-Gurion University of the Negev
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18731
[Presentation] Terabiology: Understanding of biomolecular functions that utilize thermal fluctuations in the terahertz region.2019
- Author(s)
  今清水正彦、田中真人、保科宏道、竹内恒
- Organizer
  The 84th Annual Meeting of the Israel Chemical Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18731
[Presentation] 遺伝子発現のテラバイオロジー:テラヘルツ領域のゆらぎ運動から遺伝子発現の分子機能を理解する。2019
- Author(s)
  今清水正彦、田中真人、保科宏道、竹内恒
- Organizer
  第13回日本ゲノム微生物学会年会
- Data Source
  KAKENHI-PROJECT-18K18731
[Presentation] 反復DNA配列にコードされた生物の熱揺らぎ利用戦略：転写調節の統計的解釈によって見えてきたこと。2019
- Author(s)
  今清水正彦, 高橋弘喜, David B. Lukatsky
- Organizer
  第91回日本遺伝学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K18731
[Presentation] Terahertz radiation and temperature increase: Opposite effect on transcription by RNA polymerase2019
- Author(s)
  今清水正彦, 田中真人, 杉山順一、保科宏道, 竹内恒
- Organizer
  9th ILANIT/FISEB Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18731
[Presentation] テラバイオロジー:テラヘルツ領域のゆらぎ運動から生物機能を理解する。2018
- Author(s)
  今清水正彦、田中真人、保科宏道、竹内恒
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K18731
[Presentation] Control of transcriptional pausing by biased thermal fluctuations on repetitive genomic sequences2017
- Author(s)
  今清水　正彦
- Organizer
  The 1934thBiological Symposium on NIG
- Invited
- Data Source
  KAKENHI-PROJECT-16H06692
[Presentation] Control of transcriptional pausing by biased thermal fluctuations on repetitive genomic sequences2017
- Author(s)
  Masahiko Imashimizu
- Organizer
  The 1934thBiological Symposium on NIG
- Place of Presentation
  国立遺伝学研究所
- Year and Date
  2017-04-20
- Invited
- Data Source
  KAKENHI-PROJECT-16H06692
[Presentation] 転写調節機構：熱揺らぎ、反復配列、転写pausingの繋がり2017
- Author(s)
  今清水　正彦
- Organizer
  第19回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-16H06692
[Presentation] Control of transcriptional pausing by biased thermal fluctuations on repetitive genomic sequences2016
- Author(s)
  Masahiko Imashimizu, Ariel Afek, Hiroki Takahashi, and David B. Lukatsky
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-16H06692

1. 徳永裕二 (80713354)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. 田中真人 (30386643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
3. 佐々木章 (30580162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 竹内恒

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Imashimizu Masahiko 今清水 正彦

Research Projects

Research Products

Co-Researchers

Contribution of hydration in transcription fidelity: Understanding the molecular basis and its regulation by subterahertz waves.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding biological functions based on the heterogeneity of hydration water dynamicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Revisiting genetic information: introducing the concept of the collective dynamics of DNA and waterPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Detection and control of functional vibrations of biomolecular machines by resonance phenomenaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular Design of RNA aptamersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Nonthermal acceleration of protein hydration by sub-terahertz irradiation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Repetitive DNA symmetry elements negatively regulate gene expression in embryonic stem cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nonthermal excitation effects mediated by subterahertz radiation on hydrogen exchange in ubiquitin2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Control of Transcription Initiation by Biased Thermal Fluctuations on Repetitive Genomic Sequences2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RNA Polymerase and Transcription Mechanisms: The Forefront of Physicochemical Studies of Chemical Reactions2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gre factors prevent thermal and mechanical stresses induced by terahertz irradiation during transcription2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcription Factor Binding in Embryonic Stem Cells Is Constrained by DNA Sequence Repeat Symmetry2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The role of pyrophosphorolysis in the initiation-to-elongation transition by E. coli RNA polymerase2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-round isolation of diverse RNA aptamers from a random sequence pool2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcription pausing: biological significance of thermal fluctuations biased by repetitive genomic sequences2018

Imashimizu Masahiko 今清水正彦