Yanagiba Yukie 柳場由絵

… Alternative Names

YANAGIBA Yukie 柳場由絵

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Researcher Number	90467283
Other IDs
Affiliation (Current)	2025: 独立行政法人労働者健康安全機構労働安全衛生総合研究所, 化学物質情報管理研究センター生体防御評価研究室, 室長 2025: 独立行政法人労働者健康安全機構労働安全衛生総合研究所, 化学物質情報管理研究センター有害性評価研究部, 上席研究員
Affiliation (based on the past Project Information) *help	2020: 独立行政法人労働者健康安全機構労働安全衛生総合研究所, 化学物質情報管理研究センター有害性評価研究部, 上席研究員 2016 – 2019: 独立行政法人労働者健康安全機構労働安全衛生総合研究所, 産業毒性・生体影響研究グループ, 主任研究員 2014 – 2015: 独立行政法人労働安全衛生総合研究所, その他部局等, 研究員 2011 – 2015: 独立行政法人労働安全衛生総合研究所, 健康障害予防研究グループ, 研究員 2013: 独立行政法人労働安全衛生総合研究所 2013: 独立行政法人労働安全衛生総合研究所, 健康障害予防研究, 研究員 2011: 独立行政法人労働衛生研究所, 研究員
Review Section/Research Field	Principal Investigator Hygiene and public health / Hygiene Except Principal Investigator Hygiene and public health / Hygiene
Keywords	Principal Investigator 肝障害 / CYP2E1 / 生物学的モニタリング / 薬物代謝 / 衛生 / 産業中毒 / 胆管癌 / 1,2-ジクロロプロパン / 代謝物 / 経皮曝露 … More / 膀胱がん / 胆管がん / 薬物代謝酵素 / 中間代謝物 / オルトトルイジン / ジクロロプロパン / 毒性メカニズム / 炎症 / 個体差要因 / 酸化ストレス / 有機溶剤 / 肝機能障害 / ジメチルアセトアミド / DMAC … More Except Principal Investigator ALDH2 / 遺伝毒性 / 遺伝子多型 / CYP2E1 / 代謝 / １,２－ジクロロプロパン / 活性酸素種 / ヒストンH2AXリン酸化 / 代謝活性化 / 1,2-ジクロロプロパン / 職業性胆管癌 / オフセット印刷工程 / 産業保健 / 感受性 / 毒性評価 / バイオ燃料 / 国際情報交換 / 代謝酵素 / ETBE / トリクロロエタノール / サイトカイン / HLA多型 / 工場労働者 / 全身性皮膚-肝障害 / HLA-B1301 / 健康労働者 / 生物学的許容値 / 対照者 / 患者 / HLA-B^1301多型 / 疫学研究 / トリクロロ酢酸 / IL10 / TNFα / HHV6 / HLA-B* 1301 / Hypersensitivity / トリクロロエチレン Less

Establishment of Toxicity Assessment System for Industrial Chemicals by Drug Metabolizing Enzyme CYP2E1Principal Investigator
- Principal Investigator
  
  Yanagiba Yukie
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hygiene and public health
- Research Institution
  National Institute of Occupational Safety and Health,Japan
The study of health effects of workers in Offset printing
- Principal Investigator
  
  TSUKAHARA Teruomi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene and public health
- Research Institution
  Shinshu University
Study on the metabolic activation and genotoxic effects of chlorinated organic solvents
- Principal Investigator
  
  Wang Rui-Sheng
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene and public health
- Research Institution
  National Institute of Occupational Safety and Health,Japan
Health effects of the biofuel ETBE as modified by the genetic polymorphisms of its metabolizing enzyme
- Principal Investigator
  
  WANG Rui-Sheng
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  National Institute of Occupational Safety and Health, Japan
Study on the health effects of industrial chemical with potential hepatotoxicityPrincipal Investigator
- Principal Investigator
  
  YANAGIBA Yukie
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hygiene
- Research Institution
  National Institute of Occupational Safety and Health, Japan
Epidemiological study on environmental and genetic factor of trichlroetylene-induced hypersensitivity
- Principal Investigator
  
  NASU Tamie
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Nagoya University

All 2019 2017 2016 2015 2014 2012 2010 2009 Other

All Journal Article Presentation

[Journal Article] 産業化学物質のマウス経皮ばく露方法の検討2019
- Author(s)
  小林健一、柳場由絵
- Journal Title
  
  Journal of Occupational Safety and Health
  
  Volume: 12 Issue: 3 Pages: 195-198
- DOI
  10.2486/josh.JOSH-2019-0013-GI
- NAID
  130007720300
- ISSN
  1882-6822, 1883-678X
- Year and Date
  2019-09-30
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15862
[Journal Article] Acute inhalation co-exposure to 1,2-dichloropropane and dichloromethane cause liver damage by inhibiting mitochondrial respiration and defense ability in mice.2019
- Author(s)
  Wang H, Chen J, Suda M, Yanagiba Y, Weng Z, Wang RS.
- Journal Title
  
  J Appl Toxicol.
  
  Volume: 39(2) Issue: 2 Pages: 260-270
- DOI
  10.1002/jat.3715
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15862
[Journal Article] 1,2-Dichloropropane generates phosphorylated histone H2AX via cytochrome P450 2E1-mediated metabolism.2017
- Author(s)
  Toyooka T, Yanagiba Y, Suda M, Ibuki Y, Wang RS.
- Journal Title
  
  Toxicology Letters
  
  Volume: 272 Pages: 60-67
- DOI
  10.1016/j.toxlet.2017.03.009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H06893, KAKENHI-PROJECT-26460817
[Journal Article] Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARalpha-Humanized Mice.2010
- Author(s)
  Ramdhan DH, Kamijima M, Wang D, Ito Y, Naito H, Yanagiba Y, Hayashi Y, Tanaka N, Aoyama T, Gonzalez FJ, Nakajima T.
- Journal Title
  
  Environmental Health Perspective
  
  Volume: 118(11) Pages: 1557-1563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21406016
[Journal Article] Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARα-Humanized Mice2010
- Author(s)
  Ramdhan DH, Kamijima M, Wang D, Ito Y, Naito H, Yanagiba Y, Hayashi Y, TanakaN, Aoyama T, Gonzalez FJ, Nakajima T.
- Journal Title
  
  Environ Health Perspect
  
  Volume: 118 Pages: 1557-1563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21406016
[Presentation] 1,2-Dichloropropane and its metabolites display genotoxicity in human liver- and bile duct-derived cells2016
- Author(s)
  R.S. Wang, T. Toyooka, Y. Yanagiba, M. Suda
- Organizer
  14th International Congress of Toxicology
- Place of Presentation
  Merida, Mexico
- Year and Date
  2016-05-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460817
[Presentation] Detection of DNA double-strand breaks in the liver of mice exposed to 1,2-dichloropropane2016
- Author(s)
  Rui-Sheng Wang, Tatsushi Toyooka, Yukie Yanagiba and Megumi Suda
- Organizer
  The 55th Annual Meeting of the Society of Toxicology
- Place of Presentation
  ルイジアンナ州ニューオーリンズ市
- Year and Date
  2016-03-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460817
[Presentation] Intermediate metabolites of 1,2-dichloropropane are responsible for the genotoxic effects in mice2016
- Author(s)
  Rui-Sheng Wang, Yukie Yanagiba, Tatsushi Toyooka and Megumi Suda
- Organizer
  52nd European Congress of the European Societies of Toxicology
- Place of Presentation
  Seville, Spain
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460817
[Presentation] インビトロ及びインビボにおける1,2-ジクロロプロパンのDNA損傷について2016
- Author(s)
  王　瑞生，豊岡達士，柳場由絵，須田　恵
- Organizer
  第89回日本産業衛生学会
- Place of Presentation
  福島市
- Year and Date
  2016-05-24
- Data Source
  KAKENHI-PROJECT-26460817
[Presentation] 1,2-ジクロロプロパン曝露時の血液・胆汁中の代謝物濃度の比較2016
- Author(s)
  須田　恵，柳場由絵，鈴木哲矢，豊岡達士，王　瑞生
- Organizer
  第44回産業中毒・生物学的モニタリング研究会
- Place of Presentation
  東京
- Year and Date
  2016-08-04
- Data Source
  KAKENHI-PROJECT-26460817
[Presentation] Mechanistic Study on the Hepatotoxic Effects of 1,2-Dichloropropane in ALDH2 Knockout Mice2015
- Author(s)
  Rui-Sheng Wang, Tetsuya Suzuki, Yukie Yanagiba, Megumi Suda
- Organizer
  51st Congress of the European Society of Toxixology
- Place of Presentation
  ポルトガル、ポルト市
- Year and Date
  2015-09-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460817
[Presentation] 1,2-ジクロロプロパン吸入ばく露後のマウス肝臓におけるDNA損傷について2015
- Author(s)
  王　瑞生，豊岡達士，柳場由絵，須田　恵
- Organizer
  第43回産業中毒・生物学的モニタリング研究会
- Place of Presentation
  愛知県南知多
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26460817
[Presentation] Assessment of the reproductive toxicity of inhalation exposure to Ethyl tertiary Butyl Ether in male mice with normal, low active and inactive ALDH2.2014
- Author(s)
  Rui-Sheng Wang, Zuquan Weng, Katsumi Ohtani, Megumi Suda and Yukie Yanagiba
- Organizer
  The 53rd Annual Meeting of Siciety of Toxicology
- Place of Presentation
  USA
- Data Source
  KAKENHI-PROJECT-23590766
[Presentation] Assessment of the reproductive toxicity of inhalation exposure to Ethyl tertiary Butyl Ether in male mice with normal, low active and inactive ALDH22014
- Author(s)
  Rui-Sheng Wang, Zuquan Weng, Katsumi Ohtani, Megumi Suda and Yukie Yanagiba
- Organizer
  The 53rs Annual Meeting of the Society of Toxicology, Toxicologist 2014
- Place of Presentation
  (page 442)
- Data Source
  KAKENHI-PROJECT-23590766
[Presentation] Oxidative metabolism effects of inhalation exposure to dimethylacetamide.2012
- Author(s)
  Yukie Yanagiba, Megumi Suda, Rui-Sheng Wang, Hisayo Kubota, Rieko Hojo, Tamie Nakajima
- Organizer
  The 6th international Congress of Asian Society of Toxicology
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23790681
[Presentation] DMAC吸入曝露による肝臓における酸化ストレスの増加2012
- Author(s)
  (柳場由絵)、須田恵、王瑞生、扇祖銓、久保田久代、北條理恵子、那須民江
- Organizer
  第85回日本産業衛生学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-06-01
- Data Source
  KAKENHI-PROJECT-23790681
[Presentation] ETBE低濃度ばく露後マウスの各種組織におけるDNA損傷について2012
- Author(s)
  王　瑞生, 須田　恵, 大谷勝己, 柳場由絵, 鈴木哲矢
- Organizer
  第４０回産業中毒・生物学的モニタリング研究会
- Place of Presentation
  神奈川県三浦市
- Data Source
  KAKENHI-PROJECT-23590766
[Presentation] ETBE低濃度ばく露後マウスの各種組織におけるDNA損傷について2012
- Author(s)
  王瑞生, 須田恵, 大谷勝己, 柳場由絵, 鈴木哲矢
- Organizer
  第40回産業中毒・生物学的モニタリング研究会
- Place of Presentation
  (抄録集,p24)
- Data Source
  KAKENHI-PROJECT-23590766
[Presentation] ジメチルアセトアミド吸入ばく露による肝臓での酸化的代謝への影響について2012
- Author(s)
  (柳場由絵)、須田恵、王瑞生、久保田久代、北條理恵子、那須民江
- Organizer
  第39回日本毒性学会
- Place of Presentation
  仙台国際センター
- Year and Date
  2012-07-18
- Data Source
  KAKENHI-PROJECT-23790681
[Presentation] ジメチルアセトアミド吸入曝露による肝臓における酸化ストレスの増加2012
- Author(s)
  (柳場由絵)、須田恵、王瑞生、扇祖銓、久保田久代、北條理恵子、那須民江
- Organizer
  第82回日本衛生学会
- Place of Presentation
  京都大学
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-23790681
[Presentation] ジメチルアセトアミド吸入曝露による肝臓での酸化的代謝への影響について.2012
- Author(s)
  柳場由絵，須田　恵，王　瑞生，翁　祖銓，久保田久代，北條理恵子，那須民江
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23790681
[Presentation] トリクロロエチレン誘発性肝障害におけるPPARα活性の種差による影響について2010
- Author(s)
  Ramdhan DH, 上島通浩, 王棟, 伊藤由起, 柳場由絵, 林由美, 内藤久雄, Gonzalez FJ, 那須民江
- Organizer
  第83回日本産業衛生学会
- Place of Presentation
  福井、フェニックス・プラザ
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-21406016
[Presentation] トリクロロエチレン誘発性肝障害におけるPPARα活性の種差による影響について2010
- Author(s)
  Ramdhan DH, 上島通浩, 王棟, 伊藤由起, 柳場由絵, 林由美, 内藤久雄, Gonzalez FJ, 那須民江
- Organizer
  第83回日本産業衛生学会
- Place of Presentation
  福井国際交流会館
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-21406016
[Presentation] DIFFERENTIAL RESPONSE TOTRICHLOROETHYLENE-INDUCEDHEPATOSTEATOSIS IN WILD-TYPEAND PPARA-HUMANIZED MICE2010
- Author(s)
  Ramdhan DH, Kamijima M, Wang D, Ito Y, Yanagiba Y, Hayashi Y, Naito H, Gonzalez FJ, Nakajima T.
- Organizer
  XII International Congress of Toxicology
- Place of Presentation
  Barcelona-Spain Palau de Congressosde Barcelona
- Data Source
  KAKENHI-PROJECT-21406016
[Presentation] DIFFERENTIAL RESPONSE TO TRICHLOROETHYLENE-INDUCED HEPATOSTEATOSIS IN WILD-TYPE AND PPARA-HUMANIZED MICE2010
- Author(s)
  Ramdhan DH, Kamijima M, Wang D, Ito Y, Yanagiba Y, Hayashi Y, Naito H, Gonzalez FJ, Nakajima T
- Organizer
  XII International Congress of Toxicology
- Place of Presentation
  Palau de Congressos de Barcelona(Barcelona, Spain)
- Data Source
  KAKENHI-PROJECT-21406016
[Presentation] DIFFERENTIAL RESPONSE TO TRICHLOROETHYLENE-INDUCED HEPATOSTEATOSIS IN WILD-TYPE AND PPARA-HUMANIZRD MICE2010
- Author(s)
  Ramdhan DH, Kamijima M, Wang D, Ito Y, Yanagiba Y, Hayashi Y, Naito H, Gonzalez FJ, Nakajima T
- Organizer
  XII International Congress of Toxicology
- Place of Presentation
  Barcelona-Spain Palau de Congressos de Barcelona
- Data Source
  KAKENHI-PROJECT-21406016
[Presentation] トリクロロエチレン誘発性肝障害におけるPPARα活性の種差による影響について2010
- Author(s)
  Ramdhan DH,上島通浩,王棟,伊藤由起,柳場由絵,林由美,内藤久雄, Gonzalez FJ,那須民江
- Organizer
  第83回日本産業衛生学会総会
- Place of Presentation
  福井、福井国際交流会館
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-21406016
[Presentation] HHV6バリアントと再活性化2009
- Author(s)
  柳場由絵
- Organizer
  第79回日本衛生学会総会
- Place of Presentation
  東京北里大学白金キャンパス
- Year and Date
  2009-03-30
- Data Source
  KAKENHI-PROJECT-21406016
[Presentation] Aldh2 遺伝子ノックアウトマスにおける 1,2 -ジクロロプロパンの遺伝毒性について
- Author(s)
  王　瑞生，鈴木哲矢，柳場由絵，須田　恵
- Organizer
  第42回産業中毒・生物学的モニタリング研究会
- Place of Presentation
  松本市
- Year and Date
  2014-10-25 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-26460817

1. SUZUKI Tetsuya (20573950)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. WANG Rui-Sheng (10321895)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. SUDA Megumi (90415969)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
4. NASU Tamie (10020794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. KAMIJIMA Michihiro (80281070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. WENG Zuquan (10541170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. TSUKAHARA Teruomi (50377652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 野見山哲生 (70286441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 津田洋子 (80512904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 伊吹裕子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 豊岡達士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yanagiba Yukie 柳場 由絵

YANAGIBA Yukie 柳場 由絵

Research Projects

Research Products

Co-Researchers

Establishment of Toxicity Assessment System for Industrial Chemicals by Drug Metabolizing Enzyme CYP2E1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of health effects of workers in Offset printing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the metabolic activation and genotoxic effects of chlorinated organic solvents

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Health effects of the biofuel ETBE as modified by the genetic polymorphisms of its metabolizing enzyme

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the health effects of industrial chemical with potential hepatotoxicityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Epidemiological study on environmental and genetic factor of trichlroetylene-induced hypersensitivity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 産業化学物質のマウス経皮ばく露方法の検討2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Acute inhalation co-exposure to 1,2-dichloropropane and dichloromethane cause liver damage by inhibiting mitochondrial respiration and defense ability in mice.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 1,2-Dichloropropane generates phosphorylated histone H2AX via cytochrome P450 2E1-mediated metabolism.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARalpha-Humanized Mice.2010

Author(s)

Journal Title

Data Source

[Journal Article] Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARα-Humanized Mice2010

Author(s)

Journal Title

Data Source

[Presentation] 1,2-Dichloropropane and its metabolites display genotoxicity in human liver- and bile duct-derived cells2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Detection of DNA double-strand breaks in the liver of mice exposed to 1,2-dichloropropane2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Yanagiba Yukie 柳場由絵

YANAGIBA Yukie 柳場由絵