YASUI Norihisa 安井典久

Researcher Number	90467514
Other IDs	https://orcid.org/0000-0001-7117-3070
Affiliation (based on the past Project Information) *help	2025: 岡山大学, 医歯薬学域, 准教授 2021 – 2023: 岡山大学, 医歯薬学域, 准教授 2018 – 2020: 岡山大学, 医歯薬学総合研究科, 准教授 2016 – 2017: 岡山大学, 医歯薬学総合研究科, 助教 2013 – 2015: 岡山大学, 医歯(薬)学総合研究科, 助教 2008 – 2009: Osaka University, 蛋白質研究所, 助教
Review Section/Research Field	Principal Investigator Structural biochemistry / Basic Section 43030:Functional biochemistry-related / Medium-sized Section 38:Agricultural chemistry and related fields / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Biomolecular chemistry Except Principal Investigator Biological Sciences
Keywords	Principal Investigator 一本鎖モネリン / 人工タンパク質 / モネリン / ファージディスプレイ / LDL受容体 / 人工結合タンパク質 / 分子シャペロン / 進化分子工学 / 蛋白質 / エンドサイトーシス … More / ファージディスプレイライブラリー / 組換えタンパク質 / 難発現タンパク質 / コラーゲン / プライベートシャペロン / 分子骨格 / メンブレントラフィック / 代理リガンド / 単鎖モネリン / 合成生物学 / タンパク質 / 相互作用 / GPCR / Fab断片 / 味覚受容体 / 抗体 / エンドサイトーシ / 細胞外タンパク質 / 脳・神経 / 受容体 / リーリン … More Except Principal Investigator リーリン / 電子顕微鏡 / X線結晶解析 / 受容体 / 細胞外マトリックス / 電子顕微鏡イメージング / X線結晶構造解析 / シグナル分子 / 基底膜 / インテグリン / リガンド複合体 / 構造解析 / シグナル伝達 Less

人工結合タンパク質の創製に基づくLDL受容体の細胞内輸送経路決定機構の解明Principal Investigator
- Principal Investigator
  
  安井典久
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Okayama University
Reconstitution of artificial private chaperone systems and their application to the production of difficult-to-express proteinsPrincipal Investigator
- Principal Investigator
  
  Yasui Norihisa
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Okayama University
Mechanisms of membrane trafficking of LDL receptor family members investigated by the generation of surrogate ligandsPrincipal Investigator
- Principal Investigator
  
  Yasui Norihisa
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Okayama University
Reconstitution of private chaperone systems using synthetic binding proteinsPrincipal Investigator
- Principal Investigator
  
  Yasui Norihisa
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Okayama University
Generation and characterization of monoclonal antibodies against the extracellular regions of taste receptorsPrincipal Investigator
- Principal Investigator
  
  YASUI Norihisa
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Structural biochemistry
- Research Institution
  Okayama University
構造情報を用いた手法で明らかにするリーリンシグナルとエンドサイトーシスの関係Principal Investigator
- Principal Investigator
  
  安井典久
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
Structural analyses of the interaction between extracellular ligands and their receptors
- Principal Investigator
  
  TAKAGI Junichi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University

[Journal Article] Chemical range recognized by the ligand-binding domain in a representative amino acid-sensing taste receptor, T1r2a/T1r3, from medaka fish2024
- Author(s)
  Ishida Hikaru、Yasui Norihisa、Yamashita Atsuko
- Journal Title
  
  PLOS ONE
  
  Volume: 19 Issue: 3 Pages: e0300981-e0300981
- DOI
  10.1371/journal.pone.0300981
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19084, KAKENHI-PROJECT-23K27117
[Journal Article] Chloride ions evoke taste sensations by binding to the extracellular ligand-binding domain of sweet/umami taste receptors2023
- Author(s)
  Atsumi N, Yasumatsu K, Takashina Y, Ito C, Yasui N, Margolskee RF, Yamashita A
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.84291
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K02415, KAKENHI-PUBLICLY-21H05524, KAKENHI-PROJECT-19H02841, KAKENHI-PROJECT-20H03195, KAKENHI-PROJECT-20H03855, KAKENHI-PROJECT-21K19084
[Journal Article] Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis2023
- Author(s)
  Okuda, K. et al.,
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 621-621
- DOI
  10.1038/s41467-023-36232-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19380, KAKENHI-PROJECT-20H00543, KAKENHI-PROJECT-19H02841, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-23K17374, KAKENHI-PROJECT-23K06482, KAKENHI-PROJECT-21K19084, KAKENHI-PROJECT-19H05640, KAKENHI-PUBLICLY-22H05568
[Journal Article] Investigating the Effect of Substituting a Single Cysteine Residue on the Thermal Stability of an Engineered Sweet Protein, Single-Chain Monellin2023
- Author(s)
  Ohnuma Kyosuke、Yamashita Atsuko、Yasui Norihisa
- Journal Title
  
  The Protein Journal
  
  Volume: 42 Issue: 6 Pages: 698-708
- DOI
  10.1007/s10930-023-10154-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19084, KAKENHI-PROJECT-23K27117
[Journal Article] Direct binding of calmodulin to the cytosolic C-terminal regions of sweet/umami taste receptors2023
- Author(s)
  Yoshida Atsuki、Ito Ayumi、Yasui Norihisa、Yamashita Atsuko
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 174 Issue: 5 Pages: 451-459
- DOI
  10.1093/jb/mvad060
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19084, KAKENHI-PROJECT-23K27117
[Journal Article] A sweet protein monellin as a non-antibody scaffold for synthetic binding proteins2021
- Author(s)
  Yasui N, Nakamura K, Yamashita A
- Journal Title
  
  J. Biochem.
  
  Volume: 169 Issue: 5 Pages: 585-599
- DOI
  10.1093/jb/mvaa147
- NAID
  120007182873
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H04778, KAKENHI-PROJECT-19H02841, KAKENHI-PROJECT-20H03195
[Journal Article] 受容体タンパク質を用いた味覚感知初反応の解析と応用2021
- Author(s)
  山下　敦子, 芦川　雄二, 南後　恵理子, 安井　典久
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 79 Pages: 86-89
- NAID
  40022533057
- Data Source
  KAKENHI-PROJECT-19H02841
[Journal Article] Structural studies of reelin N-terminal region provides insights into a unique structural arrangement and functional multimerization2020
- Author(s)
  Nagae Masamichi、Suzuki Kei、Yasui Norihisa、Nogi Terukazu、Kohno Takao、Hattori Mitsuharu、Takagi Junichi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: mvaa144 Issue: 5 Pages: 1-41
- DOI
  10.1093/jb/mvaa144
- NAID
  40022623693
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06575, KAKENHI-PROJECT-20K07051, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-19H02841, KAKENHI-PROJECT-19H03170, KAKENHI-PROJECT-19K22504, KAKENHI-PROJECT-20H03384, KAKENHI-PROJECT-21K19342, KAKENHI-PROJECT-20K20581
[Journal Article] Differential scanning fluorimetric analysis of the amino-acid binding to taste receptor using a model receptor protein, the ligand-binding domain of fish T1r2a/T1r32019
- Author(s)
  Takashi Yoshida, Norihisa Yasui, Yuko Kusakabe, Chiaki Ito ,Miki Akamatsu, Atsuko Yamashita
- Journal Title
  
  PLoS ONE
  
  Volume: 14 Issue: 10 Pages: e0218909-e0218909
- DOI
  10.1371/journal.pone.0218909
- NAID
  120006860091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K02192, KAKENHI-PUBLICLY-18H04621, KAKENHI-PROJECT-17H03644, KAKENHI-PROJECT-19H02841, KAKENHI-PROJECT-17K19354
[Journal Article] Specific modification at the C-terminal lysine residue of the green fluorescent protein variant, GFPuv, expressed in Escherichia coli2019
- Author(s)
  Takahiro Nakatani, Norihisa Yasui, Issei Tamura & Atsuko Yamashita
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 4722-4722
- DOI
  10.1038/s41598-019-41309-8
- NAID
  120006777526
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04621, KAKENHI-PROJECT-17H03644, KAKENHI-PROJECT-15H05370
[Journal Article] Structural basis for perception of diverse chemical substances by T1r taste receptors2017
- Author(s)
  Nuemket Nipawan、Yasui Norihisa、Kusakabe Yuko、Nomura Yukiyo、Atsumi Nanako、Akiyama Shuji、Nango Eriko、Kato Yukinari、Kaneko Mika K.、Takagi Junichi、Hosotani Maiko、Yamashita Atsuko
- Journal Title
  
  Nat Commun.
  
  Volume: 8 Issue: 1 Pages: 15530-15530
- DOI
  10.1038/ncomms15530
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05370, KAKENHI-PROJECT-15K00796, KAKENHI-PROJECT-17H01420
[Journal Article] Functional analyses of specific protein-protein interaction networks using affinity clamping technology2017
- Author(s)
  安井　典久
- Journal Title
  
  生化学
  
  Volume: 89 Issue: 2 Pages: 293-297
- DOI
  10.14952/SEIKAGAKU.2017.890293
- NAID
  40021203455
- ISSN
  0037-1017
- Year and Date
  2017-04-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-15H05370
[Journal Article] Structural basis for ligand capture and release by the endocytic receptor ApoER2.2017
- Author(s)
  Hirai H, Yasui N, Yamashita K, Tabata S, Yamamoto M, Takagi J, Nogi T
- Journal Title
  
  EMBO reports
  
  Volume: 18 Issue: 6 Pages: 982-999
- DOI
  10.15252/embr.201643521
- NAID
  130007420865
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19206, KAKENHI-PROJECT-26291016, KAKENHI-PROJECT-15H05370, KAKENHI-PROJECT-17H01420
[Journal Article] Immunoaffinity Purification of the Glycosylated Extracellular Fragment of Mouse Plexin A2 Produced in a Mammalian Expression System.2017
- Author(s)
  Nogi T, Mihara E, Yasui N, Takagi J
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1493 Pages: 57-72
- DOI
  10.1007/978-1-4939-6448-2_4
- ISBN
  9781493964468, 9781493964482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26291016, KAKENHI-PROJECT-15H05370
[Journal Article] Taste substance binding elicits conformational change of taste receptor T1r heterodimer extracellular domains2016
- Author(s)
  E. Nango, S. Akiyama, S. Maki-Yonekura, Y. Ashikawa, Y. Kusakabe, E. Krayukhina, T. Maruno, S. Uchiyama, N. Nuemket, K. Yonekura, M. Shimizu, N. Atsumi, N. Yasui, T. Hikima, M. Yamamoto, Y. Kobayashi, A. Yamashita
- Journal Title
  
  Sci. Rep
  
  Volume: 6 Issue: 1 Pages: 25745-25745
- DOI
  10.1038/srep25745
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04757, KAKENHI-PROJECT-15H05370, KAKENHI-PROJECT-15K06986
[Journal Article] 翻訳後修飾を含むアミノ酸配列を高特異的に認識する人工結合タンパク質2015
- Author(s)
  安井典久, 服部峰充, 小出昌平
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 73 Pages: 292-296
- NAID
  40020536333
- Data Source
  KAKENHI-PROJECT-15H05370
[Journal Article] 人工タンパク質を用いたタンパク質間相互作用構築による細胞内シグナル伝達ネットワークの詳細解析2015
- Author(s)
  安井典久
- Journal Title
  
  生物物理
  
  Volume: 55 Pages: 151-153
- NAID
  130005072027
- Open Access
- Data Source
  KAKENHI-PROJECT-15H05370
[Journal Article] Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation.2014
- Author(s)
  Yasui, N., Findlay, G.M., Gish, G.D., Hsiung, M.S., Huang, J., Tucholska, M., Taylor, L., Smith, L., Boldridge W.C., Koide, A., Pawson, T, Koide, S.
- Journal Title
  
  Mol Cell
  
  Volume: 54 Issue: 6 Pages: 1034-1041
- DOI
  10.1016/j.molcel.2014.05.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25891017
[Journal Article] Structural basis for specific recognition of reelin by its receptors.2010
- Author(s)
  Yasui, Norihisa
- Journal Title
  
  Structure 18
  
  Pages: 320-331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Detection of endogenous LRP6 expressed on human cells by monoclonal antibodies specific for the native conformation.2010
- Author(s)
  Yasui, Norihisa
- Journal Title
  
  J.Immunol.Methods 352
  
  Pages: 153-160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Structural basis for specific recognition of reelin by its receptors.2010
- Author(s)
  Yasui N, Nogi T, Takagi
- Journal Title
  
  Structure 18
  
  Pages: 320-331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Detection of endogenous LRP6 expressed on human cells by monoclonal antibodies specific for the native conformation.2010
- Author(s)
  Yasui N, Mihara E, Nampo M, Tamura-Kawakami K, Unno H, Matsumoto K, Takagi
- Journal Title
  
  J. immunol. Methods 352
  
  Pages: 153-160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] 脳の層構造形成を司る細胞外タンパク質リーリンの構造生物学2008
- Author(s)
  安井典久
- Journal Title
  
  生物物理 48
  
  Pages: 235-238
- NAID
  110006839205
- Data Source
  KAKENHI-PROJECT-20770084
[Journal Article] Structure of F-spondin reeler domain reveals a unique β-sandwich fold with a deformable disulfide-bonded loop.2008
- Author(s)
  Nagae, M., Nishikawa, K., Yasui, N., Yamasaki, M., Nogi, T., Takagi, J.
- Journal Title
  
  Acta Crystallographica D64
  
  Pages: 1138-1145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Novel affinity tag system using structurally defined antibody-tag interaction: Application to single-step protein purification.2008
- Author(s)
  Nogi, T., Sangawa, T., Tabata, S., Nagae, M., Tamura-Kawakami, K., Beppu, A., Hattori, M., Yasui, N., Takagi, J.
- Journal Title
  
  Protein Sci. 17
  
  Pages: 2120-2126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] receptor-binding reelin fragment and mutational analysis reveal a recognition mechanism similar to endocytic receptors.2007
- Author(s)
  Yasui, N., Nogi, T., Kitao, T., Nakano, Y., Hattori, M., Takagi, J.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 104
  
  Pages: 9988-9993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Structure of a receptor-binding reelin fragment and mutational analysis reveal a recognition mechanism similar to endocytic receptors.2007
- Author(s)
  Yasui, Norihisa
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 104
  
  Pages: 9988-9993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Journal Article] Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomography.2006
- Author(s)
  Nogi, T., Yasui, N., Hattori, M., Iwasaki, K., Takagi, J.
- Journal Title
  
  EMBO J. 25
  
  Pages: 3675-3683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] システイン残基への変異導入がもたらす一本鎖モネリンの安定性変化2023
- Author(s)
  大沼　恭介, 山下　敦子, 安井　典久
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19H02841
[Presentation] LDL受容体とそれを標的とする人工結合タンパク質の相互作用の構造基盤2023
- Author(s)
  安井　典久，中村　祐介，山下　敦子
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K19084
[Presentation] システイン残基への変異導入がもたらす一本鎖モネリンの安定性変化2023
- Author(s)
  大沼　恭介, 山下　敦子, 安井　典久
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K19084
[Presentation] メダカ由来味覚受容体T1r2a/T1r3リガンド結合領域に対する疎水性アミノ酸の作用解析および結合構造解析2022
- Author(s)
  新田　純矢, 安井　典久, 堤　尚孝, 山下　敦子
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K19084
[Presentation] メダカ由来味覚受容体T1r2a/T1r3細胞外領域のリガンド結合解析2022
- Author(s)
  石田　光，安井　典久，山下　敦子
- Organizer
  日本味と匂学会第56回大会
- Data Source
  KAKENHI-PROJECT-21K19084
[Presentation] LDL受容体リガンド結合領域を標的とする人工結合タンパク質の作製2022
- Author(s)
  安井　典久, 中村　祐介, 山下　敦子
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K19084
[Presentation] メダカ由来味覚受容体T1r2a/T1r3リガンド結合領域に対する疎水性アミノ酸の作用解析および結合構造解析2022
- Author(s)
  新田　純矢, 安井　典久, 堤　尚孝, 山下　敦子
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H02841
[Presentation] メダカ由来味覚受容体T1r2a/T1r3細胞外領域のリガンド結合解析2022
- Author(s)
  石田　光，安井　典久，山下　敦子
- Organizer
  日本味と匂学会第56回大会
- Data Source
  KAKENHI-PROJECT-19H02841
[Presentation] LDL受容体リガンド結合領域を標的とする人工結合タンパク質の作製2022
- Author(s)
  安井　典久, 中村　祐介, 山下　敦子
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H02841
[Presentation] 一本鎖モネリンを非抗体分子骨格とするGFP結合タンパク質の作製と分子特性解析2019
- Author(s)
  安井　典久, 山下　敦子
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19H02841
[Presentation] 味覚受容体T1R2/T1R3リガンド結合領域カチオン結合部位の構造生物学的解析2019
- Author(s)
  伊藤　千晶，安井　典久，渥美　菜奈子，山下　敦子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H02841
[Presentation] 様々な組換え発現条件下でのGFPuv C末端Lys残基の翻訳後修飾2019
- Author(s)
  田村　一晟，安井　典久，守屋　央朗，山下　敦子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H02841
[Presentation] 非抗体分子骨格を用いた人工結合タンパク質作製基盤の構築2019
- Author(s)
  安井　典久
- Organizer
  第71回日本生物工学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H02841
[Presentation] 新規な非抗体分子骨格に基づく人工結合タンパク質のファージディスプレイライブラリーの作製2019
- Author(s)
  安井　典久, 山下　敦子
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H02841
[Presentation] 一本鎖モネリンを分子骨格とする人工結合タンパク質ファージディスプレイライブラリーの構築2018
- Author(s)
  安井　典久，山下　敦子
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-15H05370
[Presentation] 分子骨格として一本鎖モネリンを用いたGFPを標的とする人工結合タンパク質の作製とその分子特性解析2018
- Author(s)
  安井　典久，山下　敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15H05370
[Presentation] 表面プラズモン共鳴法による味覚受容体T1R細胞内C末端領域とカルシウム結合タンパク質の相互作用の速度論的解析2018
- Author(s)
  吉田　涼希，安井　典久，山下　敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15H05370
[Presentation] サーマルシフトアッセイによる味覚受容体細胞外領域に対するアミノ酸の結合解析2018
- Author(s)
  吉田　高志，安井　典久，渥美　菜奈子, 山下　敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15H05370
[Presentation] Expression, purification, and characterization of the entire heterodimeric extracellular regions of fish taste receptor2017
- Author(s)
  Hiroki Maruhashi, Daisuke Noshiro, Norihisa Yasui, Toshio Ando, Atsuko Yamashita
- Organizer
  第55回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-15H05370
[Presentation] X線結晶構造解析によるメダカT1r2a/T1r3細胞外領域への無機金属イオン結合解析2017
- Author(s)
  渥美　菜奈子, 安井　典久, 山下　敦子
- Organizer
  日本味と匂学会第51回大会
- Data Source
  KAKENHI-PROJECT-15H05370
[Presentation] キチン結合ドメインを分子骨格とする人工結合タンパク質ファージディスプレイライブラリーの作製2017
- Author(s)
  安井　典久
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15H05370
[Presentation] 大腸菌組換え発現したGFPで見いだされるC末端Lys残基の翻訳後修飾2016
- Author(s)
  安井　典久, 中谷　隆寛, 山下　敦子
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15H05370
[Presentation] Fish taste receptor type 1 (T1R) extracellular domains exhibit broad specificity for ligand binding2016
- Author(s)
  Nanako Atsumi, Yukiyo Nomura, Maude W. Baldwin, Norihisa Yasui, AtsukoYamashita
- Organizer
  The 15th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05370
[Presentation] 味覚受容体T1R細胞内領域とCa2+結合タンパク質の相互作用に関する研究2016
- Author(s)
  伊藤　愛優美, 安井　典久，Nipawan Nuemket, 山下　敦子
- Organizer
  日本薬学会第136回年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-15H05370
[Presentation] 人工タンパク質を用いた細胞内相互作用ネットワークの再構築によるマウスES細胞の分化に重要なタンパク質間相互作用の同定2014
- Author(s)
  安井　典久, Greg M. Findlay, Gerald Gish, Marilyn S. Hsiung, Jin Huang, Monika Tucholska, Lorne Taylor, Louis Smith, W. Clifford Boldridge, 小出明子, Tony Pawson, 小出　昌平
- Organizer
  第37回分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-25891017
[Presentation] 味覚受容体T1Rとカルモジュリンの相互作用2014
- Author(s)
  伊藤　愛優美, 安井　典久，山下　敦子
- Organizer
  第37回分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-25891017
[Presentation] 特定の配列モチーフに単一特異的に結合する人工タンパク質の作製とその利用によるタンパク質間相互作用の機能アノテーション2014
- Author(s)
  安井　典久, Greg M. Findlay, Gerald Gish, Marilyn S. Hsiung, Jin Huang, Monika Tucholska, Lorne Taylor, Louis Smith, W. Clifford Boldridge, 小出明子, Tony Pawson, 小出　昌平
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-26
- Invited
- Data Source
  KAKENHI-PROJECT-25891017
[Presentation] Dissection of the molecular architecture of higher-order assembly of the full-length reelin2009
- Author(s)
  Norihisa, Yasui
- Organizer
  23rd Symposium of The Protein Society
- Place of Presentation
  Boston Marriott Copley Place, Boston (米国)
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] 全長リーリンの精製法の確立とリーリン会合体の構造化学的基盤の解明2009
- Author(s)
  安井典久
- Organizer
  第8回日本蛋白質科学会
- Place of Presentation
  熊本全日空ホテルニュースカイ(熊本県)
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20770084
[Presentation] Dissection of the molecular architecture of higher-order assembly of the full-length reelin2009
- Author(s)
  Yasui, N.
- Organizer
  23rd Symposium of The Protein Society
- Place of Presentation
  Boston(USA)
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] 全長リーリンの精製法の確立とリーリン会合体の構造化学的基盤の解明2009
- Author(s)
  安井、典久
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本全日空ホテルニュースカイ
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] 全長リーリンの精製法の確立とリーリン会合体の構造化学的基盤の解明2009
- Author(s)
  安井典久
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] リーリン会合体の構造的基盤とその機能的意義2009
- Author(s)
  安井典久
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] リーリン会合体の構造的基盤とその機能的意義2009
- Author(s)
  安井、典久
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ボートアイランド
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation]2009
- Author(s)
  Norihisa Yasui
- Organizer
  23rd Annual Symposium of The Protein Society
- Place of Presentation
  The Boston Marriott Copley(米国)
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-20770084
[Presentation] リーリン工受容体複合体の結晶構造解析2008
- Author(s)
  安井典久
- Organizer
  第8回日本蛋白質科学会年会
- Place of Presentation
  東京
- Year and Date
  2008-06-10
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] リーリンー受容体複合体の結晶構造解析2008
- Author(s)
  安井典久
- Organizer
  第8回日本蛋白質科学会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2008-06-10
- Data Source
  KAKENHI-PROJECT-20770084
[Presentation] Crystal structure of reelin in complex with its receptor2008
- Author(s)
  Yasui, Norihisa
- Organizer
  XXI Congress of the International Union of Crystallo graphy
- Place of Presentation
  Grand Cube Osaka, Osaka, Japan
- Year and Date
  2008-08-23
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] Structural basis for recognition of reelin by its neuronal receptor2008
- Author(s)
  Norihisa Yasui
- Organizer
  22nd Annual Sympositim of The Protein Society
- Place of Presentation
  Manchester Grand Hyatt San Diego, San Diego
- Year and Date
  2008-07-21
- Data Source
  KAKENHI-PROJECT-20770084
[Presentation] Crystal structure of reelin in complex with its receptor2008
- Author(s)
  Norihisa Yasui
- Organizer
  Twenty-First Congress and General Assembly of the International Union of Crystallography
- Place of Presentation
  Grand Cube Osaka (Osaka International Convention Center)
- Data Source
  KAKENHI-PROJECT-20770084
[Presentation] Structural basis for recognition of reelin by its neuronal receptor2008
- Author(s)
  Yasui, Norihisa
- Organizer
  22nd Annual Symposium of The Protein Society
- Place of Presentation
  San Diego, Manchester Grand Hyatt San Diego
- Year and Date
  2008-07-29
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] Structural basis for recognition of reelin by its neuronal receptor2008
- Author(s)
  Yasui, N.
- Organizer
  22nd Annual Symposium of The Protein Society
- Place of Presentation
  San Diego (USA)
- Year and Date
  2008-07-29
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] リーリン-受容体複合体の結晶構造解析2008
- Author(s)
  安井、典久
- Organizer
  第8回日本蛋白質科学会年会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2008-06-10
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] 受容体によるリーリン認識の構造的基盤2007
- Author(s)
  安井典久
- Organizer
  第7回日本蛋白質科学会年会
- Place of Presentation
  仙台
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-17082004
[Presentation] 受容体によるリーリン認識の構造的基盤2007
- Author(s)
  安井、典久
- Organizer
  第7回日本蛋白質科学会年会
- Place of Presentation
  仙台国際センター
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-17082004

1. NOGI Terukazu (40379102)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. TAKAGI Junichi (90212000)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. IWASAKI Kenji (20342751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 山下敦子 (10321738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. YASUMATSU Keiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. YONEKURA Koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. Maki Saori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 長江雅倫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 日下部裕子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YASUI Norihisa 安井 典久

Research Projects

Research Products

Co-Researchers

人工結合タンパク質の創製に基づくLDL受容体の細胞内輸送経路決定機構の解明Principal Investigator

Principal Investigator

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Reconstitution of artificial private chaperone systems and their application to the production of difficult-to-express proteinsPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Mechanisms of membrane trafficking of LDL receptor family members investigated by the generation of surrogate ligandsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Reconstitution of private chaperone systems using synthetic binding proteinsPrincipal Investigator

Principal Investigator

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Research Institution

Generation and characterization of monoclonal antibodies against the extracellular regions of taste receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

構造情報を用いた手法で明らかにするリーリンシグナルとエンドサイトーシスの関係Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural analyses of the interaction between extracellular ligands and their receptors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Chemical range recognized by the ligand-binding domain in a representative amino acid-sensing taste receptor, T1r2a/T1r3, from medaka fish2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chloride ions evoke taste sensations by binding to the extracellular ligand-binding domain of sweet/umami taste receptors2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Investigating the Effect of Substituting a Single Cysteine Residue on the Thermal Stability of an Engineered Sweet Protein, Single-Chain Monellin2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Direct binding of calmodulin to the cytosolic C-terminal regions of sweet/umami taste receptors2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A sweet protein monellin as a non-antibody scaffold for synthetic binding proteins2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] 受容体タンパク質を用いた味覚感知初反応の解析と応用2021

Author(s)

Journal Title

YASUI Norihisa 安井典久