Araya Jun 荒屋潤

… Alternative Names

ARAYA Jun 荒屋潤

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Researcher Number	90468679
Other IDs
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2025: 東京慈恵会医科大学, 医学部, 教授 2013 – 2018: 東京慈恵会医科大学, 医学部, 准教授 2017: 東京慈恵会医科大学, 医学部, 講師 2014: 東京慈恵会医科大学, 呼吸器内科, 教授 2009 – 2013: Jikei University School of Medicine, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine / Basic Section 49050:Bacteriology-related
Keywords	Principal Investigator オートファジー / 慢性閉塞性肺疾患 / 細胞老化 / 細胞外分泌小顆粒 / metabolic reprograming / 細胞外分泌小胞顆粒 / 特発性肺線維症 / lipofibroblast / Extracellular vesicle / ガレクチン３ … More / COPD / TRIM16 / Galectin3 / リソソーム / リソファジー / ラミンB1 / Deptor / Lamin B1 / ｍTOR / TGF-β … More Except Principal Investigator COPD / 細胞老化 / 慢性閉塞性肺疾患 / オートファジー / IPF / エクソソーム / 特発性肺線維症 / サルコペニア / Parkin / 細胞死 / ミトコンドリア / 酸化ストレス / アポトーシス / Senotherapy / senotherapy / 気道上皮 / 閉塞性肺疾患 / 気管支喘息 / フェロトーシス / 脂質酸化 / microRNA / 間質性肺炎 / マイトファジー / マイクロRNA / 肺機能 / 増悪 / 肺線維症 / 肺損傷 / 老化のエンドタイプ / 老化関連分泌現象 / 肺アスペルギルス症 / シングルセル・マルチオミクス / 糖鎖 / cgas-sting / cGAS-STING / PPARα / 加齢 / PPAR / TFEB / 制御されたネクローシス / 細胞運命 / コロナ禍 / 肺がん検診 / 喫煙刺激 / コロナ禍での肺がん検診 / トロンボスポンジン-1 / 筋収縮 / 筋肥大 / カルジオリピン / Mieap液滴 / Mieap / 脂質ラジカル / 易炎症性 / 易感染性 / 免疫老化 / NCOA4 / LaminB1 / PARK2 / 線維化 / i-ULCs / HO-1 / statin / 体表肺エコー検査 / 肺胞マクロファージ / scRNA-seq / 2型肺胞上皮 / 細胞外小胞 / II型肺胞上皮 / 特発性肺線維症(IPF) / アグリファジー / アグリゾーム / 環境因子 / 遺伝子多型 / 特発性肺線維症（IPF） / TOLLIP / ミトコンドリアUPR / ミトコンドリア異常 / ROS産生 / SITH-1 / HHV-7 / HHV-6 / 疲労 / ACOS / 術後合併症 / 喘息 / 好酸球性副鼻腔炎 / 術後肺合併症 / 抗SITH-1抗体 / ヒトヘルペスウイルス / 難治化 / オードファジー / 樹状細胞 / 鉄 / フェリチノファジー / 活性酸素 / 分子細胞呼吸器病 / 活性酸素種 / ヒト気道上皮細胞 / LAMP2A / シャペロン介在性オートファジー / 繊維芽細胞 / 気道上皮細胞 / マイクロＲＮＡ / PGE-MUM / 喫煙 / インフラマソーム / 呼吸器疾患 / micro RNA / ｌｕｎｇ　ｉｎｊｕｒｙ / ｅｘｏｓｏｍｅ / ｍｉｃｒｏ　ＲＮＡ / ｓｅｎｅｓｃｅｎｃｅ / ｐｕｌｍｏｎａｒｙ　ｆｉｂｒｏｓｉｓ / ＣＯＰＤ / TNF-alpha / 肺機能早期減衰 / Multiplex Real-time PCR / 細菌定着 / クラム陰性桿菌 / 喘息合併COPD / ヘムオキシゲナーゼ-1 / 喘息COPDオーバーラップ症候群 / 全身性炎症 / 難治化増悪 / 肺機能急速減衰 / フェノタイプ / 肺線維芽細胞 / 肺上皮細胞 / 老化 Less

II型肺胞上皮細胞の幹細胞性制御メカニズムからみた特発性肺線維症病態の解明Principal Investigator
- Principal Investigator
  
  荒屋潤
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
エクソソーム表面糖鎖を基軸としたCOPDサルコペニア病態解明とsenotherapyの開発
- Principal Investigator
  
  藤田雄
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
Airway cell atlas of cellular senescence over lifespan
- Principal Investigator
  
  吉田昌弘
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
慢性肺アスペルギルス症における細胞老化の関与と抗老化治療開発
- Principal Investigator
  
  伊藤三郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Jikei University School of Medicine
慢性呼吸器疾患における細胞老化のエンドタイプ解析に関する研究
- Principal Investigator
  
  中山勝敏
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Akita University
難治性気管支喘息に対するSenotherapyの開発
- Principal Investigator
  
  皆川俊介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
老化細胞可視化モデルによる慢性閉塞性病態の解明とSenotherapyへの応用
- Principal Investigator
  
  和久井大
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
COPD病態におけるcGAS-STINGの重要性
- Principal Investigator
  
  原弘道
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
Development of a novel EV treatment for pulmonary fibrosis through induction of lipofibroblast differentiation.Principal Investigator
- Principal Investigator
  
  荒屋潤
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
Pathogenesis via a novel type 2 alveolar epithelial cell subgroup in COPD
- Principal Investigator
  
  Fujita Yu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
Study on cell fate commitment in chronic obstructive pulmonary disease
- Principal Investigator
  
  Nakayama Katsutoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Akita University
The development of therapeutic strategy against IPF and COPD through TFEB activation
- Principal Investigator
  
  Kuwano Kazuyoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  International University of Health and Welfare
  Jikei University School of Medicine
COPD drug discovery platform research targeting lipid oxidation.
- Principal Investigator
  
  Minagawa Shunsuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
Role of Mieap in COPD pathogenesis
- Principal Investigator
  
  Wakui Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
involvement of microRNA in the pathogenesis of COPD related sarcopenia
- Principal Investigator
  
  Hashimoto Mitsuo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Nippon Sport Science University
  Jikei University School of Medicine
Involvement of Parkin-mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease-related sarcopenia
- Principal Investigator
  
  Hirofumi Utsumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
mitochondria UPR in Idiopathic interstitial pneumonia
- Principal Investigator
  
  hara hiromichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
Aggresome-selective autophagy (aggrephagy) by TOLLIP in IPF.
- Principal Investigator
  
  Kaneko Yumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
Impaired lysophagy in COPD pathogenesis.Principal Investigator
- Principal Investigator
  
  ARAYA JUN
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
The study on Immunosenescence in Chronic Obstructive Pulmonary Disease
- Principal Investigator
  
  Nakayama Katsutoshi
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Akita University
Chaperone-mediated autophagy modulates epithelial cell apoptosis in COPD pathogenesis
- Principal Investigator
  
  Numata Takanori
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis
- Principal Investigator
  
  Minagawa Shunsuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Involvement of dendritic cells autophagy in the pathogenesis of COPD
- Principal Investigator
  
  Hashimoto Mitsuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Clinical evaluation of PGE-MUM as a biomarker in IPF
- Principal Investigator
  
  Hara Hiromichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Involvement of Lamin B1 reduction in accelerated cellular senescence during COPD pathogenesis.Principal Investigator
- Principal Investigator
  
  Jun Araya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Intracellular communication mediated by exosomal micro RNA in aging-related lung diseases
- Principal Investigator
  
  Kuwano Kazuyoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Study on the refractory mechanism in inflammatory obstructive lung disease
- Principal Investigator
  
  Nakayama Katsutoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Role of mitophagy in inflammasome activation during COPD pathogenesis.
- Principal Investigator
  
  Shimizu Kenichiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Study on the molecular and cellular markers associated with clinical phenotype of COPD
- Principal Investigator
  
  NAKAYAMA KATSUTOSHI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
The significance of signaling pathways by exososme in lung injury and fibrosis
- Principal Investigator
  
  KUWANO Kazuyoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
The cell fate regulated by autophagy and ER stress in idiopathic pulmonary fibrosis.Principal Investigator
- Principal Investigator
  
  ARAYA Jun
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Molecular mechanisms and roles of cell senescence in lung injury and repair
- Principal Investigator
  
  KUWANO Kazuyoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
The role of autophagic regulation of cellular senescence in COPD pathogenesisPrincipal Investigator
- Principal Investigator
  
  ARAYA Jun
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine

[Book] Annuall Reiew 呼吸器2013
- Author(s)
  荒屋　潤、　原　弘道、桑野和善
- Total Pages
  8
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-23591162
[Book] Apoptosis in lung diseases Modern Insights Into Disease2009
- Author(s)
  Kuwano K, Nakayama K, Araya J
- Publisher
  Apoptosis Science Publishers
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] Mitigation of acute lung injury by human bronchial epithelial cell-derived extracellular vesicles via ANXA1-mediated FPR signaling2024
- Author(s)
  Fujita Yu、Kadota Tsukasa、Kaneko Reika、Hirano Yuta、Fujimoto Shota、Watanabe Naoaki、Kizawa Ryusuke、Ohtsuka Takashi、Kuwano Kazuyoshi、Ochiya Takahiro、Araya Jun
- Journal Title
  
  Communications Biology
  
  Volume: 7 Issue: 1 Pages: 514-514
- DOI
  10.1038/s42003-024-06197-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02930
[Journal Article] Drugs against metabolic diseases as potential senotherapeutics for aging-related respiratory diseases2023
- Author(s)
  Matsubayashi Sachi、Ito Saburo、Araya Jun、Kuwano Kazuyoshi
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 14 Pages: 1-15
- DOI
  10.3389/fendo.2023.1079626
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16123, KAKENHI-PROJECT-21K08213
[Journal Article] Fibroblast-Derived Extracellular Vesicles Induce Lung Cancer Progression in the IPF Microenvironment2023
- Author(s)
  Fujita Yu、Fujimoto Shota、Miyamoto Atsushi、Kaneko Reika、Kadota Tsukasa、Watanabe Naoaki、Kizawa Ryusuke、Kawamoto Hironori、Watanabe Junko、Utsumi Hirofumi、Wakui Hiroshi、Minagawa Shunsuke、Araya Jun、Ohtsuka Takashi、Ochiya Takahiro、Kuwano Kazuyoshi
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology
  
  Volume: online ahead of print Issue: 1 Pages: 34-44
- DOI
  10.1165/rcmb.2022-0253oc
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08213, KAKENHI-PROJECT-21H02930, KAKENHI-PROJECT-20K08578
[Journal Article] Involvement of Parkin‐mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease‐related sarcopenia2022
- Author(s)
  Ito Akihiko、Hashimoto Mitsuo、Tanihata Jun、 et al.,
- Journal Title
  
  Journal of Cachexia, Sarcopenia and Muscle
  
  Volume: 13 Issue: 3 Pages: 1864-1882
- DOI
  10.1002/jcsm.12988
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09511, KAKENHI-PROJECT-20K08579
[Journal Article] Improving performance and self‐efficacy of novice nurses using hybrid simulation‐based mastery learning2022
- Author(s)
  Takashiki Rinko、Komatsu Junko、Nowicki Mari、Moritoki Yuki、Okazaki Mieko、Ohshima Shigetoshi、Hasegawa Hitoshi、Nomura Kyoko、Ouchi Gen、Berg Benjamin W.、Shirakawa Hideko、Nakayama Katsutoshi、Takahashi Naoto
- Journal Title
  
  Japan Journal of Nursing Science
  
  Volume: 20 Issue: 2
- DOI
  10.1111/jjns.12519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08149, KAKENHI-PROJECT-18K08188
[Journal Article] Anomalous Epithelial Variations and Ectopic Inflammatory Response in Chronic Obstructive Pulmonary Disease2022
- Author(s)
  Watanabe Naoaki、Fujita Yu、Nakayama Jun、Mori Yutaro、Kadota Tsukasa、Hayashi Yusuke、Shimomura Iwao、Ohtsuka Takashi、Okamoto Koji、Araya Jun、Kuwano Kazuyoshi、Yamamoto Yusuke
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology
  
  Volume: 67 Issue: 6 Pages: 708-719
- DOI
  10.1165/rcmb.2021-0555oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02721, KAKENHI-PROJECT-21H02930, KAKENHI-PROJECT-20J01794, KAKENHI-PROJECT-21K15562
[Journal Article] Impaired TRIM16-Mediated Lysophagy in Chronic Obstructive Pulmonary Disease Pathogenesis2021
- Author(s)
  J Araya, N Saito, Y Hosaka, A Ichikawa, T Kadota, Y Fujita, S Minagawa, H Hara, S Fujimoto, H Kawamoto, N Watanabe, A Ito, K Okuda, H Miyagawa, J Watanabe, D Takekoshi、H Utsumi, M Yoshida, M Hashimoto, H Wakui, S Ito, T Numata, S Mori, H Matsudaira, J Hirano, T Ohtsuka, K Nakayama, K Kuwano
- Journal Title
  
  The Journal of Immunology
  
  Volume: 207 Issue: 1 Pages: 65-76
- DOI
  10.4049/jimmunol.2001364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08188, KAKENHI-PROJECT-21K08149
[Journal Article] Chaperone-Mediated Autophagy Suppresses Apoptosis via Regulation of the Unfolded Protein Response during Chronic Obstructive Pulmonary Disease Pathogenesis2020
- Author(s)
  Hosaka Y、Araya J、Fujita Y、Kadota T、Tsubouchi K、Yoshida M、Minagawa S、Hara H、Kawamoto H、Watanabe N、Ito A、Ichikawa A、Saito N、Okuda K、Watanabe J、Takekoshi D、Utsumi H、Hashimoto M、Wakui H、Ito S、Numata T、Mori S、Matsudaira H、Hirano J、Ohtsuka T、Nakayama Katsutoshi、Kuwano K
- Journal Title
  
  The Journal of Immunology
  
  Volume: 205 Issue: 5 Pages: 1256-1267
- DOI
  10.4049/jimmunol.2000132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08188, KAKENHI-PROJECT-18K08158
[Journal Article] Efficacy of mepolizumab for patients with severe asthma and eosinophilic chronic rhinosinusitis.2019
- Author(s)
  Numata T, Nakayama K, Utsumi H, Kobayashi K, Yanagisawa H, Hashimoto M, Minagawa S, Ishikawa T, Hara H, Araya J, Kuwano K.
- Journal Title
  
  BMC Pulm Med.
  
  Volume: 19 Issue: 1 Pages: 176-176
- DOI
  10.1186/s12890-019-0952-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08188
[Journal Article] Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis2019
- Author(s)
  Saito N、Araya J、Ito S、Tsubouchi K、Minagawa S、Hara H、Ito A、Nakano T、Hosaka Y、Ichikawa A、Kadota T、Yoshida M、Fujita Y、Utsumi H、Kurita Y、Kobayashi K、Hashimoto M、Wakui H、Numata T、Kaneko Y、Asano H、Odaka M、Ohtsuka T、Morikawa T、Nakayama K、Kuwano K.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 202 Issue: 5 Pages: 1428-1440
- DOI
  10.4049/jimmunol.1801293
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08188, KAKENHI-PROJECT-18K08581
[Journal Article] Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis.2019
- Author(s)
  Yoshida M, Minagawa S, Araya J, Sakamoto T, Hara H, Tsubouchi K, Hosaka Y, Ichikawa A, Saito N, Kadota T, Sato N, Kurita Y, Kobayashi K, Ito S, Utsumi H, Wakui H, Numata T, Kaneko Y, Mori S, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Iwamoto T, Imai H, Kuwano K.
- Journal Title
  
  Nat Commun.
  
  Volume: 10 Issue: 1 Pages: 3145-3145
- DOI
  10.1038/s41467-019-10991-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08188, KAKENHI-PROJECT-17K09673, KAKENHI-PROJECT-18K14906
[Journal Article] Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis2019
- Author(s)
  Tsubouchi K、Araya J、Yoshida M、Sakamoto T、Koumura T、Minagawa S、Hara H、Hosaka Y、Ichikawa A、Saito N、Kadota T、Kurita Y、Kobayashi K、Ito S、Fujita Y、Utsumi H、Hashimoto M、Wakui H、Numata T、Kaneko Y、Mori S、Asano Hi、Matsudaira H、Ohtsuka T、Nakayama K、Nakanishi Y、Imai H、Kuwano K
- Journal Title
  
  The Journal of Immunology
  
  Volume: 203 Issue: 8 Pages: 2076-2087
- DOI
  10.4049/jimmunol.1801232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08188, KAKENHI-PROJECT-18K08581, KAKENHI-PROJECT-18K14906
[Journal Article] PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis2018
- Author(s)
  Araya Jun、Nakayama Katsutoshi、et al (26/27).
- Journal Title
  
  Autophagy
  
  Volume: 15 Issue: 3 Pages: 510-526
- DOI
  10.1080/15548627.2018.1532259
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08188
[Journal Article] Risk factors of postoperative pulmonary complications in patients with asthma and COPD.2018
- Author(s)
  Numata T, Nakayama K, Fujii S, Yumino Y, Saito N, Yoshida M, Kurita Y, Kobayashi K, Ito S, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Minagawa S, Ishikawa T, Hara H, Araya J, Kaneko Y, Kuwano K.
- Journal Title
  
  BMC Pulm Med.
  
  Volume: 18 Issue: 1 Pages: 1-8
- DOI
  10.1186/s12890-017-0570-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09233, KAKENHI-PROJECT-18K08188
[Journal Article] Detection of pathogens by real-time PCR in adult patients with acute exacerbation of bronchial asthma.2017
- Author(s)
  Yoshii Y, Shimizu K, Morozumi M, Chiba N, Ubukata K, Uruga H, Hanada S, Wakui H, Minagawa S, Hara H, Numata T, Saito K, Araya J, Nakayama K, Kishi K, Kuwano K.
- Journal Title
  
  BMC Pulm Med.
  
  Volume: 17 Issue: 1
- DOI
  10.1186/s12890-017-0494-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09233
[Journal Article] Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4.2017
- Author(s)
  Tsubouchi K, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, Kadota T, Sato N, Yoshida M, Kurita Y, Kobayashi K, Ito S, Fujita Y, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Yoshii Y, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Nakanishi Y, Kuwano K.
- Journal Title
  
  Autophagy
  
  Volume: 13(8) Issue: 8 Pages: 1420-1434
- DOI
  10.1080/15548627.2017.1328348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09231, KAKENHI-PROJECT-15K09233
[Journal Article] Mild Lung Tuberculosis in a Patient Suffering from Status Epilepticus Caused by the Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)2017
- Author(s)
  Hashimoto M, Kuriiwa S, Kojima A, Shinhuku K, Sato A, Sasaki R, Hasegawa T, Ito A, Utsumi H, Yanagisawa H, Wakui H, Minagawa S, Kojima J, Numata T, Hara H, Araya J, Kaneko Y, Nakayama K, Kuwano K.
- Journal Title
  
  Intern. Med.
  
  Volume: 56 Issue: 4 Pages: 429-433
- DOI
  10.2169/internalmedicine.56.7224
- NAID
  130005345716
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09233
[Journal Article] Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy.2017
- Author(s)
  Kurita Y, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, Kadota T, Tsubouchi K, Sato N, Yoshida M, Kobayashi K, Ito S, Fujita Y, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Yoshii Y, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Kuwano K.
- Journal Title
  
  Respir Res.
  
  Volume: 18(1) Issue: 1 Pages: 114-114
- DOI
  10.1186/s12931-017-0600-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09231, KAKENHI-PROJECT-15K09233
[Journal Article] 2. Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia.2017
- Author(s)
  Horikiri T, Hara H, Saito N, Araya J, Takasaka N, Utsumi H, Yanagisawa H, Hashimoto M, Yoshii Y, Wakui H, Minagawa S, Ishikawa T, Shimizu K, Numata T, Arihiro S, Kaneko Y, Nakayama K, Matsuura T, Matsuura M, Fujiwara M, Okayasu I, Ito S, Kuwano K.
- Journal Title
  
  Respir Med.
  
  Volume: 122 Pages: 43-50
- DOI
  10.1016/j.rmed.2016.11.017
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09194, KAKENHI-PROJECT-15K09233, KAKENHI-PROJECT-16K09558
[Journal Article] Metformin attenuates lung fibrosis development via NOX4 suppression.2016
- Author(s)
  Sato N, Takasaka N, Yoshida M, Tsubouchi K, Minagawa S, Araya J, Saito N, Fujita Y, Kurita Y, Kobayashi K, Ito S, Hara H, Kadota T, Yanagisawa H, Hashimoto M, Utsumi H, Wakui H, Kojima J, Numata T, Kaneko Y, Odaka M, Morikawa T, Nakayama K, Kohrogi H, Kuwano K.
- Journal Title
  
  Respir Res.
  
  Volume: 17 Issue: 1
- DOI
  10.1186/s12931-016-0420-x
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09233
[Journal Article] 肺線維症発症に関連する遺伝子解析2016
- Author(s)
  桑野和善, 荒屋潤, 原　弘道, 沼田尊功, 金子由美, 小島淳, 皆川俊介, 和久井大, 橋本典生, 柳澤治彦, 内海裕文, 中山勝敏.
- Journal Title
  
  Respiratory Medical Research
  
  Volume: 4 Pages: 31-35
- Data Source
  KAKENHI-PROJECT-15K09233
[Journal Article] Identification of pathogens by comprehensive real-time PCR versus conventional methods in community-acquired pneumonia in Japanese adults.2016
- Author(s)
  Yoshii Y, Shimizu K, Morozumi M, Chiba N, Ubukata K, Uruga H, Hanada S, Wakui H, Ito S, Takasaka N, Minagawa S, Kojima J, Numata T, Hara H, Kawaishi M, Saito K, Araya J, Kaneko Y, Nakayama K, Kishi K, Kuwano K.
- Journal Title
  
  Infect Dis (Lond).
  
  Volume: 48 Issue: 11-12 Pages: 782-788
- DOI
  10.1080/23744235.2016.1193788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09233
[Journal Article] Cellular senescence and autophagy in the pathogenesis of chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF).2016
- Author(s)
  Kuwano K, Araya J, Hara H, Minagawa S, Takasaka N, Ito S, Kobayashi K, Nakayama K.
- Journal Title
  
  Respir Investig.
  
  Volume: 54 Issue: 6 Pages: 397-406
- DOI
  10.1016/j.resinv.2016.03.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09233
[Journal Article] Macroscopic inflammatory tracheal and endobronchial nodules in Sjögren's syndrome.2016
- Author(s)
  Hara H, Kuwano K, Minagawa S, Numata T, Araya J, Nakayama K.
- Journal Title
  
  Thorax.
  
  Volume: - Issue: 9 Pages: 864-865
- DOI
  10.1136/thoraxjnl-2016-209390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09233
[Journal Article] Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis.2016
- Author(s)
  Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, Sato N, Yoshida M, Tsubouchi K, Kurita Y, Ito S, Fujita Y, Takasaka N, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Kojima J, Shimizu K, Numata T, Kawaishi M, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Kuwano K.
- Journal Title
  
  J Immunol.
  
  Volume: 197 Issue: 2 Pages: 504-516
- DOI
  10.4049/jimmunol.1600265
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09233
[Journal Article] A case of pulmonary lymphangioleiomyomatosis complicated with uterine and retroperitoneal tumors.2015
- Author(s)
  Numata T, Araya J, Mikami J, Hara H, Harada T, Takahashi H, Nakayama K, Kuwano K.
- Journal Title
  
  Respir Med Case Rep.
  
  Volume: 15 Pages: 71-6
- DOI
  10.1016/j.rmcr.2015.02.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09233
[Journal Article] Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis.2015
- Author(s)
  Fujita Y, Araya J, Ito S, Kobayashi K, Kosaka N, Yoshioka Y, Kadota T, Hara H, Kuwano K, Ochiya T.
- Journal Title
  
  J Extracell Vesicles
  
  Volume: 4 Issue: 1 Pages: 28388-28399
- DOI
  10.3402/jev.v4.28388
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09232
[Journal Article] PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis.2015
- Author(s)
  Ito S, Araya J, Kurita Y, Kobayashi K, Takasaka N, Yoshida M, Hara H, Minagawa S, Wakui H, Fujii S, Kojima J, Shimizu K, Numata T, Kawaishi M, Odaka M, Morikawa T, Harada T, Nishimura SL, Kaneko Y, Nakayama K, Kuwano K.
- Journal Title
  
  Autophagy
  
  Volume: 11 Pages: 547-559
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591139
[Journal Article] SIRT6のよるオートファジー制御と気道上皮細胞老化2015
- Author(s)
  高坂直樹, 荒屋潤, 栗田裕輔, 小林賢司, 伊藤三郎, 小島淳, 原弘道, 清水健一郎, 沼田尊功, 河石真, 金子由美, 中山勝敏, 桑野和善.
- Journal Title
  
  分子呼吸器病
  
  Volume: 19 Pages: 112-114
- Data Source
  KAKENHI-PROJECT-24591139
[Journal Article] PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis.2015
- Author(s)
  Ito S, Araya J, Kurita Y, Kobayashi K, Takasaka N, Yoshida M, Hara H, Minagawa S, Wakui H, Fujii S, Kojima J, Shimizu K, Numata T, Kawaishi M, Odaka M, Morikawa T, Harada T, Nishimura SL, Kaneko Y, Nakayama K, Kuwano K.
- Journal Title
  
  Autophagy.
  
  Volume: 11 Issue: 3 Pages: 547-59
- DOI
  10.1080/15548627.2015.1017190
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233, KAKENHI-PROJECT-25461198
[Journal Article] Clinical efficacy of anti-glycopeptidolipid-core IgA test for diagnosing Mycobacterium avium complex infection in lung.2015
- Author(s)
  Numata T, Araya J, Yoshii Y, Shimizu K, Hara H, Nakayama K, Kuwano K.
- Journal Title
  
  Respirology.
  
  Volume: 20 Issue: 8 Pages: 1277-81
- DOI
  10.1111/resp.12640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09233
[Journal Article] Pathogens in COPD exacerbations identified by comprehensive real-time PCR plus older methods.2015
- Author(s)
  Shimizu K, Yoshii Y, Morozumi M, Chiba N, Ubukata K, Uruga H, Hanada S, Saito N, Kadota T, Ito S, Wakui H, Takasaka N, Minagawa S, Kojima J, Hara H, Numata T, Kawaishi M, Saito K, Araya J, Kaneko Y, Nakayama K, Kishi K, Kuwano K.
- Journal Title
  
  Int J Chron Obstruct Pulmon Dis.
  
  Volume: 10 Pages: 2009-16
- DOI
  10.2147/copd.s82752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09233
[Journal Article] 肺の気腫化と線維化2014
- Author(s)
  桑野和善, 荒屋潤, 中山勝敏.
- Journal Title
  
  呼吸
  
  Volume: 33 Pages: 346-352
- Data Source
  KAKENHI-PROJECT-24591139
[Journal Article] 治療薬選択に難渋した慢性壊死性肺アスペルギルス症の1例2014
- Author(s)
  小島淳, 河石真, 荒屋潤, 中山勝敏, 桑野和善.
- Journal Title
  
  日本胸部臨床
  
  Volume: 73 Pages: 446-454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591139
[Journal Article] Intercellular communication by extracellular vesicles and their microRNAs in asthma.2014
- Author(s)
  Fujita Y, Yoshioka Y, Ito S, Araya J, Kuwano K, Ochiya T.
- Journal Title
  
  Clin Ther.
  
  Volume: 36 Issue: 6 Pages: 873-81
- DOI
  10.1016/j.clinthera.2014.05.006
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591178
[Journal Article] Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence2014
- Author(s)
  Takasaka N, Araya J, Hara H, Ito S, Kobayashi K, Kurita Y, Wakui H, Yoshii Y, Yumino Y, Fujii S, Minagawa S, Tsurushige C, Kojima J, Numata T, Shimizu K, Kawaishi M, Kaneko Y, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K.
- Journal Title
  
  J Immunol
  
  Volume: 192(3) Pages: 958-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162
[Journal Article] Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.2014
- Author(s)
  Takasaka N, Nakayama K, et al.
- Journal Title
  
  J Immunol
  
  Volume: 192 Issue: 3 Pages: 958-968
- DOI
  10.4049/jimmunol.1302341
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591139, KAKENHI-PROJECT-24591178, KAKENHI-PROJECT-25860660, KAKENHI-PROJECT-25860661
[Journal Article] Lung adenocarcinoma complicated by Trousseau's syndrome successfully treated by a combination of anticoagulant therapy and chemotherapy.2014
- Author(s)
  Yoshii Y, Numata T, Ishitobi W, Takahashi N, Wakui H, Kojima J, Shimizu K, Hara H, Ishikawa T, Kawaishi M, Saito K, Araya J, Kaneko Y, Nakayama K, Kuwano K.
- Journal Title
  
  Intern Med
  
  Volume: 53 Pages: 1835-1839
- NAID
  130004678396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591139
[Journal Article] Autophagy in the pathogenesis of pulmonary disease.2013
- Author(s)
  Araya J, Hara H, Kuwano K.
- Journal Title
  
  Intern Med
  
  Volume: 52(20) Pages: 2295-303
- NAID
  130003383668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162
[Journal Article] Apoptosis inhibitor of macrophage (AIM) expression in alveolar macrophages in COPD2013
- Author(s)
  Kojima J, Araya J, Hara H, Ito S, Takasaka N, Kobayashi K, Fujii S, Tsurushige C, Numata T, Ishikawa T, Shimizu K, Kawaishi M, Saito K, Kamiya N, Hirano J, Odaka M, Morikawa T, Hano H, Arai S, Miyazaki T, Kaneko Y, Nakayama K, Kuwano K.
- Journal Title
  
  Respir Res.
  
  Volume: 14 Pages: 30-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162
[Journal Article] Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence2013
- Author(s)
  Hara H, Araya J, Ito S, Kobayashi K, Takasaka N, Yoshii Y, Wakui H, Kojima J, Shimizu K, Numata T, Kawaishi M, Kamiya N, Odaka M, Morikawa T, Kaneko Y, Nakayama K, Kuwano K.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 305(10)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162
[Journal Article] Insufficient autophagy in idiopathic pulmonary fibrosis.2013
- Author(s)
  ARAYA J, KUWANO K, KOJIMA J ET AL.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 304 Issue: 8 Pages: 56-69
- DOI
  10.1152/ajplung.00337.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591178
[Journal Article] Insufficient autophagy in idiopathic pulmonary fibrosis.2013
- Author(s)
  Araya J, et al.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol.
  
  Volume: Jan 1;304(1): Issue: 1 Pages: L56-L69
- DOI
  10.1152/ajplung.00213.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162, KAKENHI-PROJECT-24591139
[Journal Article] Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence.2013
- Author(s)
  Hara H, Araya J, Ito S, Kobayashi K, Takasaka N, Yoshii Y, Wakui H, Kojima J, Shimizu K, Numata T, Kawaishi M, Kamiya N, Odaka M, Morikawa T, Kaneko Y, Nakayama K, Kuwano K.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol.
  
  Volume: 305(10) Issue: 10 Pages: L737-L746
- DOI
  10.1152/ajplung.00146.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162, KAKENHI-PROJECT-24591139, KAKENHI-PROJECT-25860661
[Journal Article] Insufficient autophagy in idiopathic pulmonary fibrosis2013
- Author(s)
  Araya J, Kojima J, Takasaka N, Ito S, Fujii S, Hara H, Yanagisawa H, Kobayashi K, Tsurushige C, Kawaishi M, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura SL, Kawabata Y, Hano H, Nakayama K, Kuwano K.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 304(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162
[Journal Article] Insufficient autophagic clearance promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease.2012
- Author(s)
  Fujii S, Hara H, Araya J, Takasaka N, Kojima J, Ito S, Minagawa S, Yumino Y, Ishikawa T, Kawaishi M, Kamiya K, Hirano J, Odaka M, Morikawa T, Stephen L Nishimura S, Nakayama K, Kuwano K
- Journal Title
  
  Oncoimmunology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] Involvement of creatine kinase B in cigarette smoke induced-bronchial epithelial cell senescence2012
- Author(s)
  Hara H, Araya J, Takasaka N, Fujii S, Kojima J, Yumino Y, Shimizu K, Ishikawa T, Numata T, Kawaishi M, Saito K, Hirano J, Odaka M, Morikawa T, Hano H, Nakayama K, Kuwano K
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 46 Pages: 306-312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease2012
- Author(s)
  Fujii S, Hara H, Araya J, Takasaka N, Kojima J, Ito S, Minagawa S, Yumino Y, Ishikawa T, Numata T, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K.
- Journal Title
  
  Oncoimmunology
  
  Volume: 1(5) Pages: 630-641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162
[Journal Article] Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells.2011
- Author(s)
  Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, Kawaishi M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol. 300(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790789
[Journal Article] エイジングと間質性肺炎2011
- Author(s)
  桑野和善、荒屋潤、原弘道
- Journal Title
  
  呼吸と循環
  
  Volume: 59 Pages: 577-585
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] Accelerated epithelial senescence in IPF and the inhibitory role of SIRT6 in TGF-beta-induced senescence of bronchial epithelila cells2011
- Author(s)
  Minagawa Y, Araya J, Kuwano K, et al
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 300 Pages: 391-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells.2011
- Author(s)
  Minagawa S, Araya J, など
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol.
  
  Volume: 300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790789
[Journal Article] Accelerated Epithelial Cell Senescence in IPF and the Inhibitory Role of SIRT6 in TGF-{beta}-induced Senescence of Human Bronchial Epithelial Cells2011
- Author(s)
  Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, Kawaishi M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] 分子呼吸器病学2011
- Author(s)
  原弘道, 藤井さと子, 荒屋潤, ほか
- Journal Title
  
  Vol.15、No.1
  
  Pages: 94-96
- Data Source
  KAKENHI-PROJECT-21790789
[Journal Article] Insulin Dependent Phosphatidylinositol 3-Kinase/Akt and ERK Signaling Pathways Inhibit TLR3-Mediated Human Bronchial Epithelial Cell Apoptosis2011
- Author(s)
  Numata T, Araya J, Fujii S, Hara H, Takasaka N, Kojima J, Minagawa S, Yumino Y, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K
- Journal Title
  
  J Immunol
  
  Volume: 187 Pages: 510-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] IPFに対する分子標的治療2010
- Author(s)
  桑野和善、荒屋潤、原弘道
- Journal Title
  
  呼吸と循環
  
  Volume: 58 Pages: 979-85
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] Fibrogenic reactions in lung diseases2010
- Author(s)
  Araya J, Nishimura SL
- Journal Title
  
  Annu Rev Pathol.
  
  Volume: 5 Pages: 77-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] 間質性肺炎に対するステロイド薬の使い方2009
- Author(s)
  桑野和善、河石真、荒屋潤
- Journal Title
  
  Modern Physician
  
  Volume: 26 Pages: 603-607
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] 分子病態から見た肺線維症2009
- Author(s)
  桑野和善、皆川俊介、荒屋潤
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 98 Pages: 1134-1139
- NAID
  10024934837
- Data Source
  KAKENHI-PROJECT-21591004
[Journal Article] 分子病態から見た肺線維症2009
- Author(s)
  桑野和善、皆川俊介、荒屋潤
- Journal Title
  
  日本内科学会雑誌 98
  
  Pages: 154-159
- NAID
  10024934837
- Data Source
  KAKENHI-PROJECT-21790789
[Journal Article] 特発性肺線維症の薬物療法2009
- Author(s)
  桑野和善、皆川俊介、荒屋潤
- Journal Title
  
  呼吸と循環
  
  Volume: 57 Pages: 575-580
- Data Source
  KAKENHI-PROJECT-21591004
[Patent] 呼吸器疾患治療剤2022
- Inventor(s)
  荒屋潤、桑野和善、伊藤三郎、松林沙知
- Industrial Property Rights Holder
  荒屋潤、桑野和善、伊藤三郎、松林沙知
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-059884
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-21K08213
[Patent] 呼吸器疾患治療剤2022
- Inventor(s)
  荒屋　潤、桑野和善、伊藤三郎、松林沙知
- Industrial Property Rights Holder
  荒屋　潤、桑野和善、伊藤三郎、松林沙知
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-21K08213
[Presentation] 肺線維症病態におけるぺマフィブラートの抗線維化作用について2024
- Author(s)
  松林沙知、荒屋潤、等
- Organizer
  第６４回呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K08213
[Presentation] Lipofibroblast由来細胞外小胞を用いた肺線維症に対する治療効果の検討2023
- Author(s)
  藤本祥太、藤田雄、荒屋潤、桑野和善
- Organizer
  第63回呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-23K24343
[Presentation] Lipofibroblast由来細胞外小胞を用いた慢性閉塞性肺疾患に対する新規治療法の開発2023
- Author(s)
  藤本祥太、藤田雄、渡邉直昭、犬養舜、西岡彩子、平野悠太、松林沙知、竹越大輔、伊藤三郎、皆川俊介、原弘道、荒屋潤
- Organizer
  第10回細胞外小胞学会
- Data Source
  KAKENHI-PROJECT-23K24343
[Presentation] Lipofibroblast derived-extracellular vesicles attenuate cigarette smoke-induced lung injury2023
- Author(s)
  S. Fujimoto, Y. Fujita, N. Watanabe, S. Matsubayashi, H. Kawamoto, D. Takekoshi, S. Ito, S. Minagawa, H. Hara, J. Araya, K. Kuwano
- Organizer
  ERS congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24343
[Presentation] Lipofibroblast derived-extracellular vesicles attenuate cigarette smoke-induced lung injury.2023
- Author(s)
  Shota Fujimoto, Yu Fujita, Jun Araya, Kazuyoshi Kuwano
- Organizer
  2023 Asia Pacific Societies for Extracellular Vesicles (APSEV) Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24343
[Presentation] 線維芽細胞由来細胞外小胞を用いた肺線維化抑制効果の検討.2022
- Author(s)
  藤本祥太、藤田雄、金子麗華、荒屋潤、桑野和善
- Organizer
  第9回日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24343
[Presentation] TFEBによるオートファジー・リソソーム制御の喫煙誘導性細胞老化およびCOPD病態への関与2022
- Author(s)
  松林沙知, 保坂悠介, 伊藤三郎, 荒屋潤, 佐々木諒子, 藤本祥太, 川本浩徳, 伊藤晶彦, 渡邉直昭, 門田宰, 藤田雄, 橋本典生, 竹越大輔, 皆川俊介, 原弘道, 沼田尊功, 桑野和善
- Organizer
  第63回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K08213
[Presentation] COPD病態におけるリソファジーの役割2019
- Author(s)
  荒屋　潤
- Organizer
  日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08158
[Presentation] COPD病態におけるシャペロン介在性オートファジーの役割の検討2019
- Author(s)
  保坂悠介、荒屋潤、皆川俊介、原弘道、伊藤晶彦、中野貴之、市川晶博、斉藤那由多、吉田昌弘、橋本典生、沼田尊功、金子由美、浅野久敏、松平秀樹、大塚崇、桑野和善
- Organizer
  日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09672
[Presentation] COPD病態におけるリソファジーの役割2019
- Author(s)
  荒屋　潤
- Organizer
  第59回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08158
[Presentation] Chaperone-mediated autophagy modulates epithelial cell apoptosis in COPD pathogenesis2019
- Author(s)
  Hosaka Y, Araya J, Fujita Y, Tsubouchi K, Minagawa S, Hara H, Nakano T, Ito A, Ichikawa A, Saito N, Kadota T, Yoshida M, Hashimoto M, Numata N, Kaneko Y, Kuwano K
- Organizer
  The European Respiratory Society International Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09672
[Presentation] COPD・喘息における術後肺合併症のリスク因子の検討2019
- Author(s)
  中山勝敏、沼田尊功、浅野真理子、奥田佑道、荒屋潤、板倉有紀、大田秀隆、桑野和善.
- Organizer
  第61回日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08188
[Presentation] COPD病態におけるシャペロン介在性オートファジー（chaperon-mediated autophagy；CMA）の役割の検討2019
- Author(s)
  保坂悠介，荒屋潤，皆川俊介，原　弘道，伊藤晶彦，中野貴之，市川晶博，斉藤那由多，吉田昌弘，橋本典生，沼田尊功，金子由美，浅野久敏，松平秀樹，大塚　崇，桑野和善
- Organizer
  第59回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09672
[Presentation] Role of chaperone-mediated autophagy in COPD pathogenesis.2018
- Author(s)
  Yusuke Hosaka, Jun Araya, Kazuya Tsubouchi, Shunsuke Minagawa, Hiromichi Hara, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Masahiro Yoshida, Takeo Ichikawa, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano.
- Organizer
  European Respiratory Society International Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08188
[Presentation] 乾癬に合併する間質性肺炎の検討2018
- Author(s)
  川本浩徳、原弘道、古部暖、奥田慶太郎、内海裕文、小林賢司、柳澤治彦、和久井大、皆川俊介、石川威夫、沼田尊功、荒屋潤、金子由美、中山勝敏、桑野和善
- Organizer
  第58回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08188
[Presentation] Involvement of GPx4-regulated lipid peroxidation in IPF pathogenesis.2018
- Author(s)
  Kazuya Tsubouchi, Jun Araya, Shunsuke Minagawa, Hiromichi Hara, Yusuke Hosaka, Akihiro Ichikawa, Nayuta Saito, Masahiro Yoshida, Takeo Ishikawa, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano
- Organizer
  European Respiratory Society International Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08188
[Presentation] Role of chaperone-mediated autophagy in COPD pathogenesis2018
- Author(s)
  Yusuke Hosaka, Jun Araya, Kazuya Tsubouchi, Shunsuke Minagawa, Hiromichi Hara, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Masahiro Yoshida, Takeo Ishikawa, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano
- Organizer
  欧州呼吸器学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09672
[Presentation] Involvement of NCOA4-mediated ferritinophagy in cigarette smoke-induced ferroptosis in COPD pathogenesis2018
- Author(s)
  Masahiro Yoshida, Shunsuke Minagawa, Jun Araya, Hiromichi Hara, Yusuke Hosaka, Akihiro Ichikawa, Nayuta Saito, Kazuya Tsubouchi, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano.
- Organizer
  European Respiratory Society International Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08188
[Presentation] 放射線照射後肺線維化進展における細胞老化の役割2018
- Author(s)
  市川晶博、原弘道、荒屋潤、皆川俊介、保坂悠介、斉藤那由多、吉田昌弘、坪内和哉、石川威夫、沼田尊功、金子由美、中山勝敏、桑野和善
- Organizer
  第58回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08188
[Presentation] 当院における重症気管支喘息に対するmepolizumab投与例の臨床的検討2018
- Author(s)
  沼田尊功、古部暖、奥田慶太郎、川本浩徳、内海裕文、小林賢司、柳澤治彦、和久井大、皆川俊介、石川威夫、原弘道、荒屋潤、金子由美、中山勝敏、桑野和善
- Organizer
  第58回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08188
[Presentation] PARK2依存性マイトファジーによる喫煙刺激誘導性細胞老化の制御2018
- Author(s)
  坪内和哉、荒屋潤、佐藤奈穂子、皆川俊介、原弘道、中山勝敏、桑野和善
- Organizer
  第58回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08188
[Presentation] Glutathione peroxidase 4（GPx4）による肺線維症病態の制御2018
- Author(s)
  坪内和哉、荒屋潤、吉田昌弘、皆川俊介、原弘道、中山勝敏、桑野和善
- Organizer
  第58回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08188
[Presentation] NCOA4依存性フェリチノファジーのCOPD病態への関与2018
- Author(s)
  吉田昌弘、皆川俊介、荒屋潤、原弘道、保坂悠介、市川晶博、斉藤那由多、坪内和哉、石川威夫、沼田尊功、金子由美、中山勝敏、桑野和善
- Organizer
  第58回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08188
[Presentation] IPF病態形成におけるRIP3制御性ネクロトーシスの関与2018
- Author(s)
  皆川俊介、吉田昌弘、荒屋潤、原弘道、坪内和哉、斉藤那由多、市川晶博、保坂悠介、川本浩徳、内海裕文、小林賢司、和久井大、沼田尊功、石川威夫、金子由美、中山勝敏、Park Sung Woo、桑野和善
- Organizer
  第58回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08188
[Presentation] Involvement ferroptosis in COPD pathogenesis.2017
- Author(s)
  Masahiro Yoshida (Tokyo, Japan), Shunsuke Minagawa, Jun Araya, Hiromichi Hara, Akihiro Ichikawa, Nayuta Saito, Nahoko Sato, Kazuya Tsubouchi, Yusuke Kurita, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano.
- Organizer
  European Respiratory Society International Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Azithromycin-mediated CHIP regulation promotes proteasomal degradation of NOX4.2017
- Author(s)
  Kazuya Tsubouchi, Jun Araya, Shunsuke Minagawa, Hiromichi Hara, Nayuta Saito, Akihiro Ichikawa, Nahoko Sato, Masahiro Yoshida, Yusuke Kurita, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano.
- Organizer
  European Respiratory Society International Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Myofibroblasts derived extracellular vesicles promotes epithelial cell senescence in idiopathic pulmonary fibrosis.2017
- Author(s)
  3.Tsukasa Kadota, Yusuke Yoshioka, Yu Fujita, Jun Araya, Kazuyoshi Kuwano, Takahiro Ochiya
- Organizer
  ISEV2017Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09232
[Presentation] PARK2-regulated mitophagy in COPD pathogenesis.2017
- Author(s)
  Nahoko Sato, Kazuya Tsubouchi, Jun Araya, Shunsuke Minagawa, Hiromichi Hara, Nayuta Saito, Masahiro Yoshida, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Takeo Ishikawa, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Hirotsugu Kohrogi, Kazuyoshi Kuwano.
- Organizer
  European Respiratory Society International Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Risk factors of postoperative pulmonary complications in bronchial asthma and COPD patients2016
- Author(s)
  Takanori Numata, Katsutoshi Nakayama, Nayuta Saito, Kazuya Tsubouchi, Nahoko Sato, Masahiro Yoshida, Yusuke Kurita, Kenji Kobayashi, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Shunsuke Minagawa, Jun Kojima, Hiromichi Hara, Jun Araya, Yumi Kaneko, Kazuyoshi Kuwano
- Organizer
  European Respiratory Society International Congress 2016 (国際学会)
- Place of Presentation
  London, UK
- Year and Date
  2016-09-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Evaluation of fatigue state with virus-related novel biomarkers in obstructive lung diseases2016
- Author(s)
  Y. Kaneko, K. Nakayama, N. Saito, K. Tsubouchi, N. Sato, M. Yoshida, Y. Kurita, K. Kobayashi, H. Utsumi, H. Yanagisawa, Mi. Hashimoto, H. Wakui, S. Minagawa, A. Kojima, H. Hara, T. Numata, J. Araya, K. Kuwano, N. Kobayashi, K. Kondo
- Organizer
  European Respiratory Society International Congress 2016 (国際学会)
- Place of Presentation
  London, UK
- Year and Date
  2016-09-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Involvement of ferroptosis in COPD pathogenesis2016
- Author(s)
  Masahiro Yoshida (Tokyo, Japan), Masahiro Yoshida, Shunsuke Minagawa, Jun Araya, Hiromichi Hara, Nayuta Saito, Nahoko Sato, Kazuya Tsubouchi, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano
- Organizer
  European Respiratory Society International Congress 2016 (国際学会)
- Place of Presentation
  London, UK
- Year and Date
  2016-09-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Pirfenidone attenuates myofibroblast differentiation during insufficient mitophagy2016
- Author(s)
  Yusuke Kurita, Jun Araya, Hiromiti Hara, Shunsuke Minagawa, Nayuta Saito, Nahoko Sato, Kazuya Tubouchi, Masahiro Yoshida, Kenji Kobayashi, Takanori Numata, Yumi Kaneko, Katutoshi Nakayama, Kazuyoshi Kuwano
- Organizer
  European Respiratory society international congress 2016 (国際学会)
- Place of Presentation
  London, UK
- Year and Date
  2016-09-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Metformin Suppresses Myofibroblast Differentiation By Inhibition Of Nox4-Mediated Smad Signaling2016
- Author(s)
  N. Sato, N. Takasaka, M. Yoshida, S. Minagawa, J. Araya, N. Saito, K. Tsubouchi, Y. Kurita, K. Kobayashi, H. Hara, J. Kojima, T. Numata, Y. Kaneko, K. Nakayama, T. Morikawa, K. Kuwano.
- Organizer
  American Thoracic Society 2016 International Conference
- Place of Presentation
  San francisco, USA
- Year and Date
  2016-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Azithromycin Suppresses TGF-β-Induced Myofibroblast Differentiation By Promoting Proteasomal Degradation Of NOX42016
- Author(s)
  K. Tsubouchi, J. Araya, H. Hara, S. Minagawa, N. Saito, N. Sato, M. Yoshida, Y. Kurita, K. Kobayashi, J. Kojima, T. Numata, Y. Kaneko, K. Nakayama, T. Morikawa, K. Kuwano,
- Organizer
  American Thoracic Society 2016 International Conference
- Place of Presentation
  San francisco, USA
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Involvement Of Lamin B1 In COPD Pathogenesis2016
- Author(s)
  Saito N, Araya J, Ito S, Kadota T, Yoshida M, Sato N, Tsubouchi K, Kurita Y, Kobayashi K, Minagawa S, Hara H, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Kojima J, Numata T, Kaneko Y, Morikawa T, Nakayama K, Kuwano K,
- Organizer
  American Thoracic Society 2016 International Conference
- Place of Presentation
  San francisco, USA
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Involvement Of PARK2-Mediated Mitophagy In Idiopathic Pulmonary Fibrosis Pathogenesis2016
- Author(s)
  Kobayashi K, Araya J, Hara H, Minagawa S, Yoshida M, Tsubouchi K, Kadota T, Saito N, Sato N, Kurita Y, Ito S, Kojima J, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Kuwano K,
- Organizer
  American Thoracic Society 2016 International Conference
- Place of Presentation
  San francisco, USA
- Year and Date
  2016-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Study On The Status Of Fatigue Among COPD, Asthma And ACOS2015
- Author(s)
  Yumi Kaneko, Katsutoshi Nakayama, Masahiro Yoshida, Yusuke Kurita, Kenji Kobayashi, Hiroshi Wakui, Yu Yoshii, Saburo Ito, Naoki Takasaka, Shunsuke Minagwa, Kenichiro Shimizu, Takanori Numata, Hiromichi Hara, Makoto Kawaishi, Jun Araya, Nobuyuki Kobayashi, Kazuhiro Kondo, Kazuyoshi Kuwano
- Organizer
  American Thoracic Society 2015 International Conference
- Place of Presentation
  Ｄｅｎｖｅｒ，ＵＳＡ
- Year and Date
  2015-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Metformin Suppresses Lung Fibrosis Development By Modulating TGF-β-Induced Myofibroblast Differentiation2015
- Author(s)
  Masahiro Yoshida, Jun Araya, Naoki Takasaka, Shunsuke Minagawa, Nahoko Sato, , Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Hiroshi Wakui, Satoko Fujii, Jun Kojima, Hiromichi Hara, Kenichiro Shimizu, Takanori Numata, Makoto Kawaishi, Yumi Kaneko, Katsutoshi Nakayama, and Kazuyoshi Kuwano,
- Organizer
  American Thoracic Society 2015 International Conference
- Place of Presentation
  Ｄｅｎｖｅｒ，ＵＳＡ
- Year and Date
  2015-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Clinical Importance Of Measuring Prostaglandin E- Major Urinary Metabolite (PGE-MUM) In Fibrotic Lung Diseases (FLDs)2015
- Author(s)
  Hiromichi Hara, Tsugumi Horikiri, Jun Araya, Naoko Sato, Masahiro Yoshida, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Naoki Takasaka, Tsukasa Kadota, Yutaka Yoshii, Hiroshi Wakui, Shunsuke Minagawa, Jun Kojima, Kenichiro Shimizu, Takanori Numata, Makoto Kawaishi, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano,
- Organizer
  American Thoracic Society 2015 International Conference
- Place of Presentation
  Ｄｅｎｖｅｒ，ＵＳＡ
- Year and Date
  2015-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Metformin Suppresses Myofibroblast Differentiation By Inhibition Of NOX4-Mediated SMAD Signaling2015
- Author(s)
  Nahoko Sato, Naoki Takasaka, Masahiro Yoshida, Shunsuke Minagawa, Jun Araya, Nayuta Saito, Kazuya Tsubouchi, Yusuke Kurita, Kenji Kobayashi, Hiromichi Hara, Jun Kojima, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Toshiaki Morikawa, and Kazuyoshi Kuwano
- Organizer
  American Thoracic Society 2015 International Conference
- Place of Presentation
  Ｄｅｎｖｅｒ，ＵＳＡ
- Year and Date
  2015-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Involvement Of Platelet-Derived Growth Factor Signaling In Mitophagic Regulation Of Myofibroblast Differentiation2015
- Author(s)
  Kenji Kobayashi, Jun Araya, Hiromichi Hara, Shunsuke Minagawa, Nahoko Sato, Masahiro Yoshida, Yusuke Kurita, Saburo Ito, Naoki Takasaka, Satoko Fujii, Jun Kojima, , Kenichiro Shimizu, Takanori Numata, Makoto Kawaishi, Yumi Kaneko, Toshiaki Morikawa, Katsutoshi Nakayama, and Kazuyoshi Kuwano,
- Organizer
  American Thoracic Society 2015 International Conference
- Place of Presentation
  Ｄｅｎｖｅｒ，ＵＳＡ
- Year and Date
  2015-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] Lamin B1 In COPD Pathogenesis2015
- Author(s)
  Saburo Ito, Jun Araya, Masahiro Yoshida, Nahoko Sato, Yusuke Kurita, Kenji Kobayashi, Naoki Takasaka, Shunsuke Minagawa, Hiromichi Hara, Shunsuke Inaki, Tsukasa Kadota, Hiroshi Wakui, Satoko Fujii, Jun Kojima, Kenichiro Shimizu, Takanori Numata, Makoto Kawaishi, Yumi Kaneko, Katsutoshi Nakayama, and Kazuyoshi Kuwano,
- Organizer
  American Thoracic Society 2015 International Conference, May 15-20, 2015 - Denver
- Place of Presentation
  Ｄｅｎｖｅｒ，ＵＳＡ
- Year and Date
  2015-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09233
[Presentation] SIRT6によるオートファジーの制御2013
- Author(s)
  高坂直樹、荒屋　潤、桑野和善、等
- Organizer
  日本呼吸器学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591178
[Presentation] Cellular senescence with insufficient autophagy of metaplastic epithelial cells in IPF.2012
- Author(s)
  Jun Araya
- Organizer
  American Thoracic Society
- Place of Presentation
  San Francisco USA
- Invited
- Data Source
  KAKENHI-PROJECT-23591162
[Presentation] Involvement of aberrant re-epithelialization with cellular senescence in IPF pathogenesis2010
- Author(s)
  Minagawa S, Araya J, Kuwano K, et al.
- Organizer
  アメリカ胸部疾患学会
- Place of Presentation
  ニューオーリンズ
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-21591004
[Presentation] Transforming Growth Factor (TGF)-βによる気道上皮細胞老化の上皮-間葉系細胞間相互作用に及ぼす影響2009
- Author(s)
  荒屋潤
- Organizer
  日本呼吸器学会
- Place of Presentation
  東京
- Year and Date
  2009-06-13
- Data Source
  KAKENHI-PROJECT-21790789
[Presentation] オートファジーによる筋線維芽細胞分化の制御
- Author(s)
  小林賢司，荒屋潤，原弘道，栗田裕輔，伊藤三郎，高坂直樹，皆川俊介，河石真，森川利昭，中山勝敏，桑野和善．
- Organizer
  第５４回日本呼吸器学会学術講演会
- Place of Presentation
  大阪国際会議場、リーガロイヤルホテル
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-24591139
[Presentation] Transcription factor EB (TFEB) regulates cigarette smoke extract (CSE)-induced cellular senescence
- Author(s)
  Yusuke Kurita, Jun Araya, Hiromiti Hara, Kenji Kobayashi, Saburo Ito, Naoki Takasaka, Hiroshi Wakui, Yutaka Yoshii, Shunsuke Minagawa, Jun Kojima, Takanori Numata, Kenichiro Shimizu, Makoto Kawaishi, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano.
- Organizer
  European Respiratory Society International Congress 2014
- Place of Presentation
  Munich, Germany
- Year and Date
  2014-09-06 – 2014-09-10
- Data Source
  KAKENHI-PROJECT-24591139
[Presentation] IgG4関連疾患による続発性肺胞蛋白症の1例
- Author(s)
  小島淳，荒屋潤，和久井大，原弘道，沼田尊功，清水健一郎，河石真，金子由美，中山勝敏，桑野和善．
- Organizer
  第５４回日本呼吸器学会学術講演会
- Place of Presentation
  大阪国際会議場、リーガロイヤルホテル
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-24591139
[Presentation] 画像上肺MAC症が疑われた症例に実施した抗GPL-core IgA抗体検査の検討
- Author(s)
  沼田尊功，高橋直子，保坂悠介，渡邊直昭，吉井悠，和久井大，皆川俊介，小島淳，原弘道，清水健一郎，河石真，荒屋潤，金子由美，中山勝敏，桑野和善．
- Organizer
  第５４回日本呼吸器学会学術講演会
- Place of Presentation
  大阪国際会議場、リーガロイヤルホテル
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-24591139
[Presentation] 網羅的real-time　PCR法を用いた成人Mycoplasma pneumoniae呼吸器感染症の臨床的検討
- Author(s)
  吉井悠，清水健一郎，宇留賀公紀，花田豪郎，岸一馬，河石真，荒屋潤，中山勝敏，諸角美由紀，千葉菜穂子，生方公子，桑野和善．
- Organizer
  第５４回日本呼吸器学会学術講演会
- Place of Presentation
  大阪国際会議場、リーガロイヤルホテル
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-24591139
[Presentation] Viral and bacterial etiologies in acute exacerbation of COPD detected using a multiplex real-time polymerase chain reaction
- Author(s)
  Kenichiro Shimizu, Yutaka Yoshii, Miyuki Morozumi, Naoko Chiba, Kimiko Ubukata, Hironori Uruga, Shigeo Hanada, Saburo Ito, Naoki Takasaka, Hiromichi Hara, Takanori Numata, Makoto Kawaishi, Jun Araya, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano.
- Organizer
  European Respiratory Society International Congress 2014
- Place of Presentation
  Munich, Germany
- Year and Date
  2014-09-06 – 2014-09-10
- Data Source
  KAKENHI-PROJECT-24591139
[Presentation] Multiplex real-time polymerase chain reaction is useful in diagnosing pathogens causing community-acquired pneumonia including atypical bacteria and viruses
- Author(s)
  Yutaka Yoshii, Kenichiro Shimizu, Miyuki Morozumi, Naoko Chiba, Kimiko Ubukata, Hironori Uruga, Shigeo Hanada, Kazuma Kishi, Hiroshi Wakui, Shunsuke Minagawa, Jun Kojima, Hiromichi Hara, Takanori Numata, Makoto Kawaishi, Jun Araya, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano.
- Organizer
  European Respiratory Society International Congress 2014
- Place of Presentation
  Munich, Germany
- Year and Date
  2014-09-06 – 2014-09-10
- Data Source
  KAKENHI-PROJECT-24591139
[Presentation] Parkin誘導性ﾏｲﾄﾌｧｼﾞｰによる喫煙刺激気道上皮細胞老化の制御
- Author(s)
  伊藤三郎，荒屋潤，栗田裕輔，小林賢司，高坂直樹，皆川俊介，小島淳，原弘道，沼田尊功，清水健一郎，河石真，金子由美，中山勝敏，桑野和善．
- Organizer
  第５４回日本呼吸器学会学術講演会
- Place of Presentation
  大阪国際会議場、リーガロイヤルホテル
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-24591139
[Presentation] PINK1-Parkin pathway-mediated mitophagy is involved in cigarette smoke extract (CSE)-induced cellular senescence in human bronchial epithelial cells (HBEC)
- Author(s)
  Saburo Ito, Jun Araya, Hiromichi Hara, Yusuke Kurita, Kenji Kobayashi, Naoki Takasaka, Hiroshi Wakui, Yutaka Yoshii, Shunsuke Minagawa, Jun Kojima, Takanori Numata, Kenichiro Shimizu, Makoto Kawaishi, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano.
- Organizer
  European Respiratory Society International Congress 2014
- Place of Presentation
  Munich, Germany
- Year and Date
  2014-09-06 – 2014-09-10
- Data Source
  KAKENHI-PROJECT-24591139
[Presentation] 進行非小細胞肺癌に対するPemetrexed治療後のS-1単剤療法の検討
- Author(s)
  河石真，和久井大，吉井悠，栗田裕輔，小林賢司，伊藤三郎，高坂直樹，皆川俊介，小島淳，清水健一郎，沼田尊功，原弘道，金子由美，荒屋潤，中山勝敏，桑野和善．
- Organizer
  第５４回日本呼吸器学会学術講演会
- Place of Presentation
  大阪国際会議場、リーガロイヤルホテル
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-24591139
[Presentation] Metformin inhibits TGF-b-induced myofibroblast differentiation through AMPK activation
- Author(s)
  Naoki Takasaka, Jun Araya, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Hiroshi Wakui, Yutaka Yoshii, Shunsuke Minagawa, Jun Kojima, Hiromichi Hara, Takanori Numata, Kenichiro Shimizu, Makoto Kawaishi, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano.
- Organizer
  European Respiratory Society International Congress 2014
- Place of Presentation
  Munich, Germany
- Year and Date
  2014-09-06 – 2014-09-10
- Data Source
  KAKENHI-PROJECT-24591139
[Presentation] Multiplex PCRによるCOPDの急性増悪に関与する病原微生物検出
- Author(s)
  清水健一郎，吉井悠，宇留賀公紀，花田豪郎，岸一馬，河石真，荒屋潤，中山勝敏，諸角美由紀，千葉菜穂子，生方公子，桑野和善．
- Organizer
  第５４回日本呼吸器学会学術講演会
- Place of Presentation
  大阪国際会議場、リーガロイヤルホテル
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-24591139
[Presentation] Mitophagic regulation of myofibroblast differentiation in lung fibroblasts
- Author(s)
  Kenji Kobayashi, Jun Araya, Hiromichi Hara, Yusuke Kurita, Saburo Ito, Naoki Takasaka, Satoko Fujii, Shunsuke Minagawa, Jun Kojima, Takanori Numata, Kenichiro Shimizu, Makoto Kawaishi, Yumi Kaneko, Toshiaki Morikawa, Katsutoshi Nakayama, Kazuyoshi Kuwano.
- Organizer
  European Respiratory Society International Congress 2014
- Place of Presentation
  Munich, Germany
- Year and Date
  2014-09-06 – 2014-09-10
- Data Source
  KAKENHI-PROJECT-24591139

1. KUWANO Kazuyoshi (40205266)

# of Collaborated Projects: 8 results

# of Collaborated Products: 30 results
2. NAKAYAMA Katsutoshi (40321989)

# of Collaborated Projects: 7 results

# of Collaborated Products: 72 results
3. Hara Hiromichi (70398791)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. Minagawa Shunsuke (70468685)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. Hashimoto Mitsuo (00771742)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. Fujita Yu (10737133)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
7. Kaneko Yumi (50646669)

# of Collaborated Projects: 2 results

# of Collaborated Products: 24 results
8. Wakui Hiroshi (10773533)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 谷端淳 (00508426)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. 伊藤三郎 (30865291)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
11. MORIKAWA Toshiaki (60292025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. ISHIKAWA Takeo (60366200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. Shimizu Kenichiro (80385327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Numata Takanori (30366257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. Hirofumi Utsumi (00773855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 吉田昌弘 (60986115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 戸根一哉 (70867423)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Saito Nayuta

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. 山本雄介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Araya Jun 荒屋 潤

ARAYA Jun 荒屋 潤

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II型肺胞上皮細胞の幹細胞性制御メカニズムからみた特発性肺線維症病態の解明Principal Investigator

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Development of a novel EV treatment for pulmonary fibrosis through induction of lipofibroblast differentiation.Principal Investigator

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Araya Jun 荒屋潤

ARAYA Jun 荒屋潤