HINO Nobumasa 樋野展正

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Hino Nobumasa 樋野展正

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Researcher Number	90469916
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院薬学研究科, 講師
Affiliation (based on the past Project Information) *help	2025: 大阪大学, 大学院薬学研究科, 講師 2022 – 2023: 大阪大学, 大学院薬学研究科, 講師 2020 – 2021: 大阪大学, 薬学研究科, 講師 2016 – 2020: 大阪大学, 薬学研究科, 助教 2012 – 2014: 大阪大学, 薬学研究科(研究院), 助教 … More 2012: 大阪大学, 大学院・薬学研究科, 助教 2009 – 2011: The Institute of Physical and Chemical Research, 拡張遺伝暗号システム研究チーム, 研究員 2008: The Institute of Physical and Chemical Research, 拡張遺伝暗号システム研究チーム, 特別研究員 Less
Review Section/Research Field	Principal Investigator Molecular biology / Basic Section 38030:Applied biochemistry-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Applied molecular and cellular biology / Biological pharmacy Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Applied health science / Medium-sized Section 38:Agricultural chemistry and related fields / Basic Section 59040:Nutrition science and health science-related / Pharmaceutical Sciences and related fields
Keywords	Principal Investigator クロスリンク / 光クロスリンク / タンパク質間相互作用 / 非天然型アミノ酸 / 人工アミノ酸 / プロテオミクス / 拡張遺伝暗号 / KEAP1 / タンパク質立体構造 / 遺伝子変異 … More / がんゲノム / 非天然アミノ酸 / 質量分析 / RAMP / GPCR / 膜タンパク質 / DNA脱メチル化 / 脱メチル化 / 組織特異的遺伝子 / エピジェネティクス / 部位特異的修飾 / 抗体薬物複合体 / tRNA / SILAC法 / RAMP1 / タンパク質問相互作用 / 蛋白質間相互作用 … More Except Principal Investigator 人工アミノ酸 / 血管内皮細胞 / PPAR / 核内受容体 / ACE2-Fc / 新型コロナ / コバレントドラッグ / タンパク質医薬品 / キナーゼ / がん融合遺伝子 / クロスリンク / タンパク質間相互作用 / 融合型キナーゼ / がんゲノム / エピジェネティクス / 転写因子 / 線維芽細胞 / ダイレクトリプログラミング / 線維化疾患 / 分子病態学 / リガンド / PGAM5 / LPIN / 立体構造解析 / 分子代謝学 / NASH / 血管生物学 / DDS / 薬学 / 抗体 / Claudin-5 / 血液脳関門 / 核内受容体PPARδ / リガンドスクリーニング / 光クロスリンク / 翻訳後修飾 / PPARδ / 生活習慣病 / 骨格筋 / 筋衛星細胞 / 未分化 / 静止期 / 骨格筋幹細胞 / Nrf2 / Notch / カルシトニン受容体 / 筋サテライト細胞 Less

共有結合性人工アミノ酸を導入することによる生体タンパク質の超機能化Principal Investigator
- Principal Investigator
  
  樋野展正
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  The University of Osaka
Development of covalent protein drug with unnatural amino acids
- Principal Investigator
  
  中川晋作
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Osaka University
Efficient identification of low-frequency gene mutations that favor cancer growthPrincipal Investigator
- Principal Investigator
  
  HINO Nobumasa
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Osaka University
Development of novel treatment for fibrotic diseases using direct reprogramming technology
- Principal Investigator
  
  Okada Yoshiaki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
Analysis of cancer specific signaling cascade by in vivo protein photo-cross-linking approach
- Principal Investigator
  
  DOI Takefumi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
Protein-protein interaction analysis focusing on mutational hotspots in cancer genomePrincipal Investigator
- Principal Investigator
  
  Hino Nobumasa
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
Development of NASH therapeutics by regulating energy expenditure and inflammation through the lipid sensor PPAR
- Principal Investigator
  
  Keisuke TACHIBANA
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Osaka University
A novel technology for regulating blood brain barrier
- Principal Investigator
  
  Okada Yoshiaki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pharmaceutical Sciences and related fields
- Research Institution
  Osaka University
Elucidation of cell fate determination mechanism of skeletal muscle stem cells
- Principal Investigator
  
  FUKADA So-ichiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Osaka University
Study on the activity of nuclear receptor PPAR delta that regulates energy expenditure
- Principal Investigator
  
  Tachibana Keisuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied health science
- Research Institution
  Osaka University
Deciphering the factors associated with selective demethylation of tissue-specific gene promoterPrincipal Investigator
- Principal Investigator
  
  Hino Nobumasa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Osaka University
Development of a system for stable expression of antibodies bearing non-natural amino acids at defined sitesPrincipal Investigator
- Principal Investigator
  
  HINO Nobumasa
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University
Investigation of GPCRs interacting with RAMPs an functional analysis of their complex.Principal Investigator
- Principal Investigator
  
  HINO Nobumasa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Osaka University
  The Institute of Physical and Chemical Research
Comprehensive analysis of membrane protein interactions by using in vivo photo-cross-linking technology.Principal Investigator
- Principal Investigator
  
  HINO Nobumasa
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  The Institute of Physical and Chemical Research

[Book] Covalently Capturing Protein Interactions in Living Cells by Site-Specific Incorporation of Photo-Cross-Linkable Amino Acids. In: Hatanaka Y., Hashimoto M. (eds) Photoaffinity Labeling for Structural Probing Within Protein.2017
- Author(s)
  Nobumasa Hino, Kensaku Sakamoto
- Total Pages
  265
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-16K21142
[Journal Article] Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models2023
- Author(s)
  Morita M, Yoneda A, Tokunoh N, Masaki T, Shirakura K, Kinoshita M, Hashimoto R, Shigesada N, Takahashi J, Tachibana M, Tanaka S, Obana M, Hino N, Ikawa M, Tsujikawa K, Ono C, Matsuura Y, Kidoya H, Takakura N, Kubota Y, Doi T, Takayama K, Yoshioka Y, Fujio Y, Okada Y.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 3
- DOI
  10.1073/pnas.2213317120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06560, KAKENHI-PROJECT-20H03382
[Journal Article] Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy2023
- Author(s)
  Ishimoto K, Konishi Y, Otani S, Maeda S, Ago Y, Hino N, Suzuki M, Nakagawa S.
- Journal Title
  
  J Nat Med.
  
  Volume: in press Issue: 3 Pages: 604-609
- DOI
  10.1007/s11418-023-01686-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11578, KAKENHI-PROJECT-21K06560, KAKENHI-PROJECT-20H03392
[Journal Article] Physicochemical and Biochemical Evaluation of Amorphous Solid Dispersion of Naringenin Prepared Using Hot-Melt Extrusion2022
- Author(s)
  Ishimoto Kenji、Shimada Yukiko、Ohno Akane、Otani Shuichi、Ago Yukio、Maeda Soya、Lin Bangzhong、Nunomura Kazuto、Hino Nobumasa、Suzuki Masayuki、Nakagawa Shinsaku
- Journal Title
  
  Frontiers in Nutrition
  
  Volume: 9 Pages: 850103-850103
- DOI
  10.3389/fnut.2022.850103
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06560, KAKENHI-PROJECT-20H03392, KAKENHI-PROJECT-20K11578
[Journal Article] Generation of KS-133 as a novel bicyclic peptide with a potent and selective VIPR2 antagonist activity that counteracts cognitive decline in a mouse model of psychiatric disorders2021
- Author(s)
  Sakamoto K, Chen L, Miyaoka T, Yamada M, Masutani T, Ishimoto K, Hino N, Nakagawa S, Asano S, Ago Y
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 12 Pages: 751587-751587
- DOI
  10.3389/fphar.2021.751587
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03392, KAKENHI-PROJECT-20K09905, KAKENHI-PROJECT-20K11578, KAKENHI-PROJECT-21K06560, KAKENHI-PROJECT-21K19714
[Journal Article] PRC2 Components Maintain DNA Hypermethylation of the Upstream Promoter and Regulate Robo4 Expression in Endothelial Cells2020
- Author(s)
  Izawa Kohei、Shirakura Keisuke、Kakiuchi Koji、Funahashi Nobuaki、Maekawa Naoki、Hino Nobumasa、Tanaka Toru、Doi Takefumi、Okada Yoshiaki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 4 Pages: 742-746
- DOI
  10.1248/bpb.b19-01014
- NAID
  130007825307
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-04-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19403, KAKENHI-PROJECT-20K11663
[Journal Article] Cupid and Psyche system for the diagnosis and treatment of advanced cancer2019
- Author(s)
  Sugiyama A, Kawamura T, Tanaka T, Doi H, Yamashita T, Shinoda K, Fujitani H, Yamatsugu K, Shimizu Y, Tatsumi T, Takahashi K, Kanai M, Mizohata E, Kawato T, Doi T, Inoue T, Kodama T.
- Journal Title
  
  Proceedings of the Japan Academy, Series B
  
  Volume: 95 Issue: 10 Pages: 602-611
- DOI
  10.2183/pjab.95.041
- NAID
  130007760701
- ISSN
  0386-2208, 1349-2896
- Year and Date
  2019-12-11
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22496, KAKENHI-PROJECT-18H03548
[Journal Article] Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase2019
- Author(s)
  Yanagisawa Tatsuo、Kuratani Mitsuo、Seki Eiko、Hino Nobumasa、Sakamoto Kensaku、Yokoyama Shigeyuki
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 26 Issue: 7 Pages: 1-14
- DOI
  10.1016/j.chembiol.2019.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19403, KAKENHI-PROJECT-16K05859
[Journal Article] Lipin-1 is a novel substrate of protein phosphatase PGAM52019
- Author(s)
  Okuno Hiroko、Okuzono Haruna、Hayase Ayaka、Kumagai Fumiko、Tanii Shohei、Hino Nobumasa、Okada Yoshiaki、Tachibana Keisuke、Doi Takefumi、Ishimoto Kenji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 509 Issue: 4 Pages: 886-891
- DOI
  10.1016/j.bbrc.2019.01.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19403, KAKENHI-PROJECT-18H03190, KAKENHI-PROJECT-17K19487
[Journal Article] Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites2019
- Author(s)
  Noguchi Yu-taro、Nakamura Miki、Hino Nobumasa、Nogami Jumpei、Tsuji Sayaka、Sato Takahiko、Zhang Lidan、Tsujikawa Kazutake、Tanaka Toru、Izawa Kohei、Okada Yoshiaki、Doi Takefumi、Kokubo Hiroki、Harada Akihito、Uezumi Akiyoshi、Gessler Manfred、Ohkawa Yasuyuki、Fukada So-ichiro
- Journal Title
  
  Development
  
  Volume: 146 Issue: 4 Pages: 163618-163618
- DOI
  10.1242/dev.163618
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19403, KAKENHI-PUBLICLY-18H04802, KAKENHI-PROJECT-16H03262, KAKENHI-PROJECT-17H03608, KAKENHI-PROJECT-17K19356, KAKENHI-PROJECT-17K19487, KAKENHI-PROJECT-16K08443
[Journal Article] ETV2-TET1/TET2 Complexes Induce Endothelial Cell-Specific Robo4 Expression via Promoter Demethylation.2018
- Author(s)
  Tanaka Toru、Izawa Kohei、Maniwa Yusuke、Okamura Maki、Okada Atsumasa、Yamaguchi Tomoko、Shirakura Keisuke、Maekawa Naoki、Matsui Hayato、Ishimoto Kenji、Hino Nobumasa、Nakagawa Osamu、Aird William C.、Mizuguchi Hiroyuki、Kawabata Kenji、Doi Takefumi、Okada Yoshiaki
- Journal Title
  
  Sci Rep.
  
  Volume: 8(1) Issue: 1 Pages: 5653-5653
- DOI
  10.1038/s41598-018-23937-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19487, KAKENHI-PROJECT-16K21142
[Journal Article] Muscle regeneration is disrupted by cancer cachexia without loss of muscle stem cell potential.2018
- Author(s)
  Inaba S, Hinohara A, Tachibana M, Tsujikawa K, Fukada SI.
- Journal Title
  
  PLoS One.
  
  Volume: 13 Issue: 10 Pages: e0205467-e0205467
- DOI
  10.1371/journal.pone.0205467
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H03262
[Journal Article] Endothelial Robo4 regulates IL-6 production by endothelial cells and monocytes via a crosstalk mechanism in inflammation2018
- Author(s)
  Shirakura Keisuke、Ishiba Ryosuke、Kashio Taito、Sakai Miki、Fukushima Yu、Yamamoto Nana、Manabe Shiori、Shigesada Naoya、Tanaka Toru、Hino Nobumasa、Aird William C.、Doi Takefumi、Okada Yoshiaki
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 495 Issue: 1 Pages: 801-806
- DOI
  10.1016/j.bbrc.2017.11.067
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19487, KAKENHI-PROJECT-16K21142
[Journal Article] The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation2018
- Author(s)
  Shirakura Keisuke、Ishiba Ryosuke、Kashio Taito、Funatsu Risa、Tanaka Toru、Fukada So-ichiro、Ishimoto Kenji、Hino Nobumasa、Kondoh Masuo、Ago Yukio、Fujio Yasushi、Yano Kiichiro、Doi Takefumi、Aird William C.、Okada Yoshiaki
- Journal Title
  
  Journal of Cell Science
  
  Volume: 132 Pages: 220228-220228
- DOI
  10.1242/jcs.220228
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19403, KAKENHI-PROJECT-17K19487, KAKENHI-PROJECT-18H02603, KAKENHI-PROJECT-18K19545
[Journal Article] Tumor Necrosis Factor α Induces the Expression of the Endothelial Cell-Specific Receptor Roundabout4 through the Nuclear Factor-κB Pathway2017
- Author(s)
  Tanaka T, Maekawa N, Kashio T, Izawa K, Ishiba R, Shirakura K, Ishimoto K, Hino N, Aird WC, Doi T, Okada Y.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 4 Pages: 504-509
- DOI
  10.1248/bpb.b16-00938
- NAID
  130005530067
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293014, KAKENHI-PROJECT-16K21142
[Journal Article] Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase2017
- Author(s)
  Ishimoto Kenji、Hayase Ayaka、Kumagai Fumiko、Kawai Megumi、Okuno Hiroko、Hino Nobumasa、Okada Yoshiaki、Kawamura Takeshi、Tanaka Toshiya、Hamakubo Takao、Sakai Juro、Kodama Tatsuhiko、Tachibana Keisuke、Doi Takefumi
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 488 Issue: 1 Pages: 159-164
- DOI
  10.1016/j.bbrc.2017.04.159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19487, KAKENHI-PROJECT-16H06390, KAKENHI-PUBLICLY-16H01382, KAKENHI-PROJECT-15H02896, KAKENHI-PROJECT-16F16725, KAKENHI-PROJECT-16K13042, KAKENHI-PROJECT-16K21142
[Journal Article] Adenovirus vector-based incorporation of a photo-cross-linkable amino acid into proteins in human primary cells and cancerous cell lines.2016
- Author(s)
  Kita A, Hino N, Higashi S, Hirota K, Narumi R, Adachi J, Takafuji K, Ishimoto K, Okada Y, Sakamoto K, Tomonaga T, Takashima S, Mizuguchi H, Doi T.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 36946-36946
- DOI
  10.1038/srep36946
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-26291035, KAKENHI-PROJECT-26293014, KAKENHI-PROJECT-16K21142
[Journal Article] Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity.2016
- Author(s)
  Ishimoto K, Kawamata N, Uchihara Y, Okubo M, Fujimoto R, Gotoh E, Kakinouchi K, Mizohata E, Hino N, Okada Y, Mochizuki Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Inoue T, Tachibana K, Doi T
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 10 Pages: e0165766-e0165766
- DOI
  10.1371/journal.pone.0165766
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H02896, KAKENHI-PROJECT-15H04644, KAKENHI-PROJECT-25282230, KAKENHI-PROJECT-26293014, KAKENHI-PROJECT-16K21142, KAKENHI-PROJECT-16H06390
[Journal Article] Endothelial cell-specific expression of roundabout 4 is regulated by differential DNA methylation of the proximal promoter2014
- Author(s)
  Okada, Y., Funahashi, N., Tanaka, T., Nishiyama, Y., Yuan, L., Shirakura, K., Turjman, A. S., Kano, Y., Naruse, H., Suzuki, A., Sakai, M., Zhixia, J., Kitajima, K., Ishimoto, K., Hino, N., Kondoh, M., Mukai, Y., Nakagawa, S., Garcia-Cardena, G., Aird, W. C., Doi, T.
- Journal Title
  
  Arterioscler Thromb. Vasc. Biol.
  
  Volume: 34 Issue: 7 Pages: 1531-1538
- DOI
  10.1161/atvbaha.114.303818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670023, KAKENHI-PROJECT-25670056, KAKENHI-PROJECT-26293014, KAKENHI-PROJECT-26713007, KAKENHI-PROJECT-26870346
[Journal Article] Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding2012
- Author(s)
  Kusano S., Kukimoto-Niino M., Hino N., Ohsawa N., Okuda K., Sakamoto K., Shirouzu M., Shindo T., Yokoyama S
- Journal Title
  
  Protein Sci
  
  Volume: 21 Issue: 2 Pages: 199-210
- DOI
  10.1002/pro.2003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570175
[Journal Article] Structural basis of interleukin-5 dimer recognition by its alpha receptor2012
- Author(s)
  Kusano S., Kukimoto-Niino M., Hino N., Ohsawa N., Ikutani M., Takaki S., Sakamoto K., Hara-Yokoyama M., Shirouzu M., Takatsu K., Yokoyama S
- Journal Title
  
  Protein Sci
  
  Volume: 21 Issue: 6 Pages: 850-864
- DOI
  10.1002/pro.2072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570175, KAKENHI-PROJECT-22590446, KAKENHI-PROJECT-24390119
[Journal Article] Site-specific incorporation of unnatural amino acids into proteins in mammalian cells2012
- Author(s)
  Hino N., Sakamoto K., Yokoyama S
- Journal Title
  
  Methods Mol. Biol
  
  Volume: 794 Pages: 215-228
- DOI
  10.1007/978-1-61779-331-8_13
- ISBN
  9781617793301, 9781617793318
- Data Source
  KAKENHI-PROJECT-22570175
[Journal Article] Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities2012
- Author(s)
  Hara-Yokoyama M., Kukimoto-Niino M., Terasawa K., Harumiya S., Podyma-Inoue K. A., Hino N., Sakamoto K., Itoh S., Hashii N., Hiruta Y., Kawasaki N., Mishima-Tsumagari C., Kaitsu Y., Matsumoto T., Wakiyama M., Shirouzu M., Kasama T., Ta
- Journal Title
  
  Structure
  
  Volume: 20 Issue: 9 Pages: 1585-1595
- DOI
  10.1016/j.str.2012.06.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570175, KAKENHI-PROJECT-22592060, KAKENHI-PROJECT-23650319, KAKENHI-PROJECT-23659108, KAKENHI-PROJECT-24657081
[Journal Article] Wade-range protein photo-crosslinking achieved by a genetically encoded N^ε-(benzyloxycarbonyl) lysine derivative with a diazirinyl moiety2012
- Author(s)
  T. Yanagisawa, N. Hino, F. Iraha, T. Mukai, K. Sakamoto, S. Yokoyama
- Journal Title
  
  Mol. Bio Syst.
  
  Volume: 8 Issue: 4 Pages: 1131-1135
- DOI
  10.1039/c2mb05321g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21550167, KAKENHI-PROJECT-22570175
[Journal Article] Genetic Incorporation of a Photo-Crosslinkable Amino Acid Reveals Novel Protein Complexes with GRB2 in Mammalian Cells.2011
- Author(s)
  樋野展正、尾山大明、佐藤文、向井崇人、伊良波史枝、林明子、秦裕子、山本雅、横山茂之、坂本健作
- Journal Title
  
  Journal of molecular biology
  
  Volume: 406 Pages: 343-353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570175
[Journal Article] Dissecting Cell Signaling Pathways with Genetically Encoded 3-Iodo-L-tyrosine.2011
- Author(s)
  林明子、樋野展正、小林隆嗣、新井亮一、白水美香子、横山茂之、坂本健作
- Journal Title
  
  Chembiochem
  
  Volume: 12 Pages: 387-389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570175
[Journal Article] Crystallographic study of a site-specifically crosslinked protein complex with a genetically incorporated photo-reactive amino acid2011
- Author(s)
  Sato S., Mimasu S., Sato A., Hino N., Sakamoto K., Umehara T., Yokoyama S.
- Journal Title
  
  Biochemistry
  
  Volume: 50 Pages: 250-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570175
[Journal Article] Crystallographic Study of a Site-Specifically Cross-Linked Protein Complex with a Genetically Incorporated Photoreactive Amino Acid.2011
- Author(s)
  佐藤心、三桝信哉、佐藤文、樋野展正、坂本健作、梅原崇史、横山茂之
- Journal Title
  
  Biochemistry
  
  Volume: 50 Pages: 250-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570175
[Journal Article] Dissecting Cell Signaling Pathways with Genetically Encoded 3-Iodo-L-tyrosine2011
- Author(s)
  Hayashi A., Hino N., Kobayashi T., Arai R., Shirouzu M., Yokoyama S., Sakamoto K
- Journal Title
  
  ChemBioChem
  
  Volume: 12 Issue: 3 Pages: 387-389
- DOI
  10.1002/cbic.201000665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570175
[Journal Article] Genetic incorporation of a photo-crosslinkable amino acid reveals novel protein complexes with GRB2 in mammalian cells2011
- Author(s)
  Hino N., Oyama M., Sato A., Mukai T., Iraha F., Hayashi A., Kozuka-Hata H., Yamamoyo T., Yokoyama S., Sakamoto K
- Journal Title
  
  J. Mol. Biol.
  
  Volume: 406 Issue: 2 Pages: 343-353
- DOI
  10.1016/j.jmb.2010.12.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570175, KAKENHI-PUBLICLY-23121506
[Journal Article] Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein.2010
- Author(s)
  田上俊輔、関根俊一、Thirumananseri Kumarevel、樋野展正、村山祐子、亀ヶ盛俊介、山本雅貴、坂本健作、横山茂之
- Journal Title
  
  Nature
  
  Volume: 468 Pages: 978-982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570175
[Journal Article] Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein2010
- Author(s)
  Tagami S., Sekine S., Kumarevel T., Hino N., Murayama Y., Kamegamori S., Yamamoto M., Sakamoto K., Yokoyama S.
- Journal Title
  
  Nature
  
  Volume: 468 Issue: 7326 Pages: 978-982
- DOI
  10.1038/nature09573
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570175
[Patent] 新規な非天然タンパク質及びその利用(N-(p-trifluoromethyldiazirinylbenzyloxycarbonyl)-lysine)2011
- Inventor(s)
  坂本健作,柳沢達男,樋野展正,伊良波史枝,横山茂之
- Industrial Property Rights Holder
  理化学研究所
- Filing Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-22570175
[Patent] 新規な非天然タンパク質、及びその利用(N-(p-trifluoromethyldiazirinylbenzyloxycarbonyl)-lysine)2011
- Inventor(s)
  坂本健作、柳沢達男、樋野展正、伊良波史枝、横山茂之
- Industrial Property Rights Holder
  理化学研究所
- Filing Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-22570175
[Presentation] 経皮感作による食物アレルギーモデルマウスにおけるシリコン製剤の抗アレルギー作用の検討（その１）2024
- Author(s)
  竹内ほのか ,田谷まる美 ,石本憲司 ,樋野展正 ,塚本智仁 ,柿沼千早, 小林悠輝 ,小林光 ,中川晋作 .
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K18004
[Presentation] 経皮感作による食物アレルギーモデルマウスにおけるシリコン製剤の抗アレルギー作用の検討（その2）2024
- Author(s)
  田谷まる美 ,竹内ほのか ,石本憲司 ,樋野展正 ,塚本智仁 ,小林悠輝 ,小林光 ,中川晋作
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K18004
[Presentation] Cross-linkable amino acid into proteins for disease pathology research and disease treatment2023
- Author(s)
  Nobumasa Hino
- Organizer
  The 8th International Conference on Pharmacy and Advanced Pharmaceutical Sciences and the 14th Annual Conference of the Indonesian Society for Cancer Chemoprevention
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18004
[Presentation] Cross-linkable amino acid into proteins for disease pathology research and disease treatment2023
- Author(s)
  Nobumasa Hino
- Organizer
  The 8th International Conference on Pharmacy and Advanced Pharmaceutical Sciences and the 14th Annual Conference of the Indonesian Society for Cancer Chemoprevention
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06560
[Presentation] 食物アレルギーモデルマウスにおけるシリコン製剤の抗アレルギー作用に関する検討2023
- Author(s)
  竹内ほのか,南佑斉,石本憲司,樋野展正,塚本智仁,小林悠輝,小林光,中川晋作
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K18004
[Presentation] SARS-CoV-2に不可逆的に結合し不活性化する次世代型ACE2-Fcの開発2023
- Author(s)
  樋野展正、高田理沙、徳納渚沙、小野慎子、大竹和正、尾上遥南、鈴木喬介、西浦崇史、塚本智仁、石本憲司、松浦善治、坂本健作、吉岡靖雄、中川晋作
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K18004
[Presentation] 機能性食品開発を目指した非晶質化β-カロテンの機能性評価2022
- Author(s)
  河本茉侑, 石本憲司, 石本憲司, 金子瑞季, 樋野展正, 中川晋作
- Organizer
  第38回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06560
[Presentation] 細胞内カルシウム流入に伴うDNA脱メチル化関連酵素TET1の活性調節機構2022
- Author(s)
  石田莉子、喜多絢海、原田和生、土井啓生、池山直輝、西浦崇史、石本憲司、藤尾慈、中川晋作、樋野展正
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06560
[Presentation] 緑茶カテキン代謝物EGC-M5はマウスの認知機能障害と抑うつ様行動を軽減する2022
- Author(s)
  山口拓海、片平海雅、山口稜太、石本憲司、樋野展正、高垣晶子、大木渉吾、鈴木壯幸、中川晋作、吾郷由希夫
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K06560
[Presentation] 新型コロナウイルス変異株に対応する次世代型ACE2-Fc製剤の開発2022
- Author(s)
  高田理沙、尾上遥南、鈴木喬介、石本憲司、大竹和正、坂本健作、吉岡靖雄、中川晋作、樋野展正
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06560
[Presentation] DNA脱メチル化関連酵素TET1の刺激依存的翻訳後修飾による活性調節2021
- Author(s)
  齋藤里緒，喜多絢海，谷口健吾，和島壮一，石田莉子，原田和生，樋野展正，土井健史
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] がん変異に影響されるFBXW7αの新規タンパク質間相互作用の探索2021
- Author(s)
  山本真実，重松知沙，山本紘義，川端猛，鳴海良平，足立淳，栗栖源嗣，樋野展正，土井健史
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 細胞内光クロスリンク法のがん関連タンパク質間相互作用解析への応用2021
- Author(s)
  樋野展正
- Organizer
  日本薬学会第141年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] タンパク質間相互作用界面の同定を可能にする新規光架橋性人工アミノ酸の開発2021
- Author(s)
  高田理彩，樋野展正，山口卓男，深田宗一朗，土井健史
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] DNA脱メチル化関連酵素TET1の刺激依存的活性調節の分子機構2021
- Author(s)
  石田莉子，喜多絢海，谷口健吾，和島壮一，斎藤里緒，原田和生，樋野展正，土井健史
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] DNA脱メチル化関連酵素TET1の刺激依存的活性調節機構の解明2020
- Author(s)
  和島壮一，喜多絢海，谷口健悟，原田和生，土井健史，樋野展正
- Organizer
  第70回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 細胞内光クロスリンク法を利用したSTK11のがん関連相互作用の探索2020
- Author(s)
  山本紘義，重松知沙，川端猛，栗栖源嗣，土井健史，樋野展正
- Organizer
  第70回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 細胞内光クロスリンク法を用いたがん変異に影響されるタンパク質間相互作用の同定2020
- Author(s)
  樋野展正
- Organizer
  日本薬学会　第140年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 細胞内光クロスリンク法を用いたがん関連因子FBXW7αの相互作用解析2020
- Author(s)
  重松知沙，山本紘義，川端猛，栗栖源嗣，土井健史，樋野展正
- Organizer
  第70回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 細胞内光クロスリンク法を用いたがん変異に影響されるタンパク質間相互作用の同定2020
- Author(s)
  樋野展正
- Organizer
  日本薬学会第140年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K19403
[Presentation] DNA脱メチル化関連酵素TET1の活性調節機構の解析2019
- Author(s)
  Jeremia Febrian, 喜多絢海, 谷口健悟, 和島壮一, 斎藤里緒, 高島成二, 土井健史, 樋野展正
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 細胞内光クロスリンク法を用いたがん特異的タンパク質間相互作用の効率的な解析系の確立2019
- Author(s)
  向山樹, 廣田康二, 鳴海良平，山本紘義，重松知沙，山本真実，足立淳，土井健史，樋野展正
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19403
[Presentation] 細胞内光クロスリンク法を利用した新規肺がん治療標的の探索2019
- Author(s)
  山本紘義，向山樹，鳴海良平，重松知沙，山本真実，足立淳，土井健史，樋野展正
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 細胞内光クロスリンク法によるDNA脱メチル化酵素TET1の活性調節因子の探索2019
- Author(s)
  和島壮一，喜多絢海，谷口健吾，Jeremia Febrian，齋藤里緒，高島成二，土井健史，樋野展正
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-18K19403
[Presentation] DNA脱メチル化関連酵素TET1の活性調節機構の解析2019
- Author(s)
  Jeremia Febrian, 喜多絢海, 谷口健悟, 和島壮一, 斎藤里緒, 高島成二, 土井健史, 樋野展正
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19403
[Presentation] 細胞内光クロスリンク法によるDNA脱メチル化酵素TET1の活性調節因子の探索2019
- Author(s)
  和島壮一，喜多絢海，谷口健吾，Jeremia Febrian，齋藤里緒，高島成二，土井健史，樋野展正
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 細胞内光クロスリンク法を利用した新規肺がん治療標的の探索2019
- Author(s)
  山本紘義，向山樹，鳴海良平，重松知沙，山本真実，足立淳，土井健史，樋野展正
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-18K19403
[Presentation] 細胞内光クロスリンク法を用いたがん特異的タンパク質間相互作用の効率的な解析系の確立2019
- Author(s)
  向山樹, 廣田康二, 鳴海良平，山本紘義，重松知沙，山本真実，足立淳，土井健史，樋野展正
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 変異集積表面への光クロスリンカー導入によるがん特異的蛋白質間相互作用の同定2019
- Author(s)
  樋野展正，向山樹，鳴海良平，川端猛，山本紘義，重松知沙，山本真実，栗栖源嗣，足立淳，土井健史_
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-18K19403
[Presentation] 変異集積表面への光クロスリンカー導入によるがん特異的蛋白質間相互作用の同定2019
- Author(s)
  樋野展正，向山樹，鳴海良平，川端猛，山本紘義，重松知沙，山本真実，栗栖源嗣，足立淳，土井健史_
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] がん変異集積表面への光クロスリンカー導入による新規KEAP1結合因子の同定2017
- Author(s)
  樋野展正，廣田康二，鳴海良平，堀越亮太，向山樹，足立淳，朝長毅，土井健史
- Organizer
  日本ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-16K21142
[Presentation] 細胞内光クロスリンク法によるTET1相互作用因子の探索2017
- Author(s)
  喜多絢海、東咲子、Jeremia Febrian、高島成二、樋野展正、土井健史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  東北大学
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K21142
[Presentation] 細胞内光クロスリンク法によるがん変異特異的タンパク質間相互作用解析2017
- Author(s)
  廣田康二，樋野展正，鳴海良平，堀越亮太，向山樹，足立淳，朝長毅，土井健史
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16K21142
[Presentation] The undifferentiated state of muscle stem cells by Notch effector genes2016
- Author(s)
  So-ichiro Fukada, Miki Nakamura, Masanobu Hino, Yu-taro Noguchi
- Organizer
  FASEB Science Research Conferences
- Place of Presentation
  Colorado, USA,
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03262
[Presentation] アデノウイルスベクターによる光架橋性アミノ酸のタンパク質への導入2016
- Author(s)
  喜多絢海、樋野展正、東咲子、廣田康二、高藤和輝、高島成二、水口裕之、土井健史
- Organizer
  第15回次世代を担う若手ファーマ・バイオフォーラム2016
- Place of Presentation
  大阪大学
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-16K21142
[Presentation] インターロイキン-5受容体α鎖による2量体インターロイキン-5認識の構造的基盤2012
- Author(s)
  草野清輔,新野睦子,樋野展正,大沢登,生谷尚士,高木智,坂本健作,横山三紀,白水美香子,高津聖志,横山茂之
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22570175
[Presentation] 新たなクロスリンカー含有非天然型アミノ酸のタンパク質への部位特異的導入と,その広域性光クロスリンク能2012
- Author(s)
  柳沢達男, 樋野展正, 伊良波史枝, 向井崇人, 坂本健作, 横山茂之
- Organizer
  第14回日本RNA学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22570175
[Presentation] ジアジリン含有ベンジルオキシカルボニルリジン誘導体のタンパク質への部位特異的導入と広域性光クロスリンク能2012
- Author(s)
  柳沢達男,樋野展正, 伊良波史枝, 向井崇人, 坂本健作, 横山茂之
- Organizer
  日本ケミカルバイオロジー学会第七回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22570175
[Presentation] RNAポリメラーゼの新規コンフォメーション状態2010
- Author(s)
  田上俊輔, 関根俊一, Thirumananseri Kumarevel, 樋野展正, 村上裕子, 亀ヶ盛俊介, 山本雅貴, 坂本健作, 横山茂之
- Organizer
  第12回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-22570175
[Presentation] タンパク質の特定のモチーフを介するタンパク質問相互作用の細胞内光クロスリンク法による網羅的解析2008
- Author(s)
  樋野展正
- Organizer
  BMB2008(第31回日本分子生物学会年会)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20770148
[Presentation] ,タンパク質の特定のモチーフを介するタンパク質間相互作用の細胞内光クロスリンク法による網羅的解析2008
- Author(s)
  樋野展正
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20770148
[Presentation] 非天然型アミノ酸含有タンパク質の安定生産系の構築
- Author(s)
  喜多絢海、一瓢奨、樋野展正、土井健史
- Organizer
  日本ケミカルバイオロジー学会第９回年会
- Place of Presentation
  大阪
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-25670023
[Presentation] プローブ転移能を有する光クロスリンカーを用いた細胞内タンパク質間相互作用解析法の開発
- Author(s)
  一瓢奨、喜多絢海、張功幸、高島成二、樋野展正、土井健史
- Organizer
  日本ケミカルバイオロジー学会第９回年会
- Place of Presentation
  大阪
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-25670023
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1. Okada Yoshiaki (50444500)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. Tachibana Keisuke (30432446)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. DOI Takefumi (00211409)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
4. FUKADA So-ichiro (20432445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 吉田卓也 (00294116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 石本憲司 (00572984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 小山正平 (80767559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山口卓男 (80596601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 中川晋作 (70207728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. 吉岡靖雄 (00392308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. Fukuda Syohei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TAKASHIMA Seiji

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. KITA Ayami

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. KONDOH masuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TAKEDA hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. AGO Yukio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. YANAGISAWA Tatsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HINO Nobumasa 樋野 展正

Hino Nobumasa 樋野 展正

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共有結合性人工アミノ酸を導入することによる生体タンパク質の超機能化Principal Investigator

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Development of covalent protein drug with unnatural amino acids

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Efficient identification of low-frequency gene mutations that favor cancer growthPrincipal Investigator

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Development of novel treatment for fibrotic diseases using direct reprogramming technology

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Analysis of cancer specific signaling cascade by in vivo protein photo-cross-linking approach

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Protein-protein interaction analysis focusing on mutational hotspots in cancer genomePrincipal Investigator

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Development of NASH therapeutics by regulating energy expenditure and inflammation through the lipid sensor PPAR

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A novel technology for regulating blood brain barrier

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Elucidation of cell fate determination mechanism of skeletal muscle stem cells

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Study on the activity of nuclear receptor PPAR delta that regulates energy expenditure

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Deciphering the factors associated with selective demethylation of tissue-specific gene promoterPrincipal Investigator

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Development of a system for stable expression of antibodies bearing non-natural amino acids at defined sitesPrincipal Investigator

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Investigation of GPCRs interacting with RAMPs an functional analysis of their complex.Principal Investigator

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HINO Nobumasa 樋野展正

Hino Nobumasa 樋野展正