NAGAI Yasuhiro 永井康裕

Researcher Number	90508962
Affiliation (based on the past Project Information) *help	2011: Tohoku University, 歯学研究科(研究院), 助教 2008 – 2010: Tohoku University, 大学院・歯学研究科, 助教 2009: 東北大, 歯学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Morphological basic dentistry Except Principal Investigator Surgical dentistry
Keywords	Principal Investigator 免疫不応答 / 免疫寛容 / 食事性肥満 / 金属アレルギー / 舌下免疫 / アレルギー / 肥満 / 免疫 / B7-H3 / 制御性T細胞 / 共刺激分子 / 間葉系幹細胞 … More Except Principal Investigator … More 薬物副作用 / 壊死 / 炎症 / 骨吸収抑制薬 / 顎骨壊死 / ビスフォスフォネート Less

舌下免疫療法を利用した腸管炎症疾患への治療法の開発Principal Investigator
- Principal Investigator
  
  永井康裕
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tohoku University
Bisphosphonate-induced jawbone necrosis : studies for its mechanism, prevention, and treatment
- Principal Investigator
  
  ENDO Yasuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tohoku University
Effect of diet-induced obesity and its immuno-defect on sublingual immunotherapy.Principal Investigator
- Principal Investigator
  
  NAGAI Yasuhiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tohoku University
口腔粘膜の間葉系幹細胞が制御する免疫抑制機構の解明Principal Investigator
- Principal Investigator
  
  永井康裕
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tohoku University

All 2010 2009 2008

All Journal Article Presentation

[Journal Article] Pro-IL-1β accumulation in macrophages by alendronate and its prevention by clodronate.2010
- Author(s)
  Yosuke Shikama, Yasuhiro Nagai , Satoru Okada, Takefumi Oizum i, Hidetoshi Shimauchi, Shunji Sugawara, Yasuo Endo.
- Journal Title
  
  Toxicology Letters
  
  Volume: 199 Pages: 123-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390529
[Journal Article] Pro-IL-1β accumulation in macrophages by alendronate and its prevention by clodronate.2010
- Author(s)
  Shikama Y, Nagai Y, Okada S1, Oizumi T, Shimauchi H, Sugawara S, Endo Y.
- Journal Title
  
  Toxicol Lett 199(2)
  
  Pages: 123-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791781
[Journal Article] Pro-IL-1ss accumulation in macrophages by alendronate and its prevention by clodronate2010
- Author(s)
  Yosuke Shikama, Yasuhiro Nagai, Satoru Okada, Takefumi Oizumi, Hidetoshi Shimauchi, Shunji Sugawara, Yasuo Endo
- Journal Title
  
  Toxicol Lett
  
  Volume: 199 Pages: 123-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390529
[Journal Article] Muramyldipeptide augments the actions of lipopolysaccharide in mice by stimulating macrophages to produce pro-IL-1 and by down-regulation of the suppressor of cytokine signaling 1 (SOCS1).2009
- Author(s)
  Shikama Y, Kuroishi T, Nagai Y, Iwakura Y, Shimauchi H, Takada T, Sugawara S, Endo Y.
- Journal Title
  
  Innate Immunity 17(1)
  
  Pages: 3-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791781
[Journal Article] Biotin status affects nickel allergy via regulation of interleukin-1beta production in mice.2009
- Author(s)
  Kuroishi T, Kinbara M, Sato N, Tanaka Y, Nagai Y, Iwakura Y, Endo Y, Sugawara S.
- Journal Title
  
  Journal of Nutrition 139
  
  Pages: 1031-1036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791781
[Journal Article] Biotin status affects nickel allergy via regulation of interleukin-1beta production in mice2009
- Author(s)
  Kuroishi T, Kinbara M, Sato N, Tanaka Y, Nagai Y, Iwakura Y, Endo Y, Sugawara S.
- Journal Title
  
  Journal of Nutrition 139
  
  Pages: 1031-1036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791781
[Journal Article] Anterior Pituitary Progenitor Cells Express Costimulatory Molecule 4Ig-B7-H32008
- Author(s)
  Nagai Y., Aso H., Ogasawara H., Tanaka S., Taketa Y., Watanabe K., Ohwada S., Rose M. T., Kitazawa H., Yamaguchi T
- Journal Title
  
  Journal of immunology 181
  
  Pages: 6073-6081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890020
[Journal Article] Anterior pituitary progenitor cells that express IL-18 and IL-18Rs serve as immuno-endocrine modulators2008
- Author(s)
  Nagai Y., Ogasawara H., Taketa Y., Aso H., Tanaka S., Kanaya T., Watanabe K., Ohwada S., Muneta Y., Yamaguchi T
- Journal Title
  
  Journal of Neuroendocrinology 20
  
  Pages: 1233-1241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890020
[Presentation] 骨吸収抑制作用とは関連しないbisphosphonates(BPs)の鎮痛作用.2010
- Author(s)
  金始瑛, 永井康裕, 山本照子, 菅原俊二, 遠藤康男.
- Organizer
  歯科基礎医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390529
[Presentation] Histamine Reduces Susceptibility to NK Cells via Down-Regulation of NKG2D Ligand Expression on Human Monocytic Leukemia THP-1 Cells.2010
- Author(s)
  Nagai Y., Tanaka Y., Kuroishi T., Sato R., Endo Y., Sugawara S.
- Organizer
  8th joint conference of the ICS and ISICR
- Place of Presentation
  Chicago, USA
- Year and Date
  2010-10-05
- Data Source
  KAKENHI-PROJECT-21791781
[Presentation] Histamine Reduces Susceptibility to NK Cells via Down-Regulation of NKG2D Ligand Expression on Human Monocytic Leukemia THP-1 Cells2010
- Author(s)
  Nagai Y., Tanaka Y., Kuroishi T., Sato R., Endo Y., Sugawara S
- Organizer
  8^<th> joint conference of the ICS and ISICR
- Place of Presentation
  Chicago, USA
- Year and Date
  2010-10-05
- Data Source
  KAKENHI-PROJECT-21791781
[Presentation] Bisphosphonates(BPs)の炎症・壊死作用:マウス耳介皮膚での検討.2010
- Author(s)
  岡田諭, 大泉丈史, 山口晃史, 永井康裕, 菅原俊二, 遠藤康男.
- Organizer
  歯科基礎医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390529
[Presentation] Analysis of antigen incorporating and processing cells in sublingal immunotherapy2010
- Author(s)
  Shiraishi D., Nagai Y., Tanaka Y., Endo Y., Shimauchi H., Sugawara S
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  Chicago, USA
- Year and Date
  2010-10-04
- Data Source
  KAKENHI-PROJECT-21791781
[Presentation] Histamine Reduces Susceptibility to NK Cells via Down-Regulation of NKG2D Ligand Expression on Human Monocytic Leukemia THP-1 Cells.2010
- Author(s)
  Nagai Y., Tanaka Y., Endo Y., Sugawara S.
- Organizer
  14th International Congress of Immunology.
- Place of Presentation
  神戸
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-21791781
[Presentation] マクロファージにおけるAlendronateによるpro-IL-1b産生誘導とそのclodronateによる抑制2010
- Author(s)
  四釜洋介, 永井康裕, 岡田諭, 大泉丈史, 島内英俊, 菅原俊二, 遠藤康男
- Organizer
  歯科基礎医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390529
[Presentation] 骨吸収抑制作用とは関連しないbisphosphonates(BPs)の鎮痛作用2010
- Author(s)
  金始瑛, 永井康裕, 山本照子, 菅原俊二, 遠藤康男
- Organizer
  歯科基礎医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390529
[Presentation] マウスNiアレルギーにおける免疫記憶型CD3+NK1.1+細胞の関与2010
- Author(s)
  永井康裕、金原正敬、田中志典、遠藤康男、菅原俊二
- Organizer
  第52回歯科基礎医学会
- Place of Presentation
  東京
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-21791781
[Presentation] Bisphosphonates(BPs)の炎症・壊死作用:マウス耳介皮膚での検討2010
- Author(s)
  岡田諭, 大泉丈史, 山口晃史, 永井康裕, 菅原俊二, 遠藤康男
- Organizer
  歯科基礎医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390529
[Presentation] マクロファーシにおけるAlendronateによるpro-IL-1β産生誘導とそのclodronateによる抑制.2010
- Author(s)
  四釜洋介, 永井康裕, 岡田諭, 大泉丈史, 島内英俊, 菅原俊二, 遠藤康男.
- Organizer
  歯科基礎医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390529
[Presentation] Analysis of antigen incorporating and processing cells in sublingal immunotherapy.2010
- Author(s)
  Shiraishi D., Nagai Y., Tanaka Y., Endo Y., Shimauchi H., Sugawara S.
- Organizer
  8th joint conference of the ICS and ISICR
- Place of Presentation
  Chicago, USA
- Year and Date
  2010-10-04
- Data Source
  KAKENHI-PROJECT-21791781
[Presentation] Histamine Reduces Susceptibility to NK Cells via Down-Regulation of NKG2D Ligand Expression on Human Monocytic Leukemia THP-1 Cells2010
- Author(s)
  Nagai Y., Tanaka Y., Endo Y., Sugawara S
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-21791781
[Presentation] Analysis of antigen incorporating and processing cells in sublingal immunotherapy2009
- Author(s)
  Shiraishi D., Nagai Y., Tanaka Y., Endo Y., Shimauchi H., Sugawara S.
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21791781
[Presentation] ヒト歯肉由来間葉系幹細胞が発現するB7-H3分子による制御性T細胞誘導とその機能解析2009
- Author(s)
  永井康裕、黒石智誠、白石大祐、大木亜紀子、島内英俊、菅原俊二
- Organizer
  第51回歯科基礎医学会
- Place of Presentation
  新潟
- Year and Date
  2009-09-09
- Data Source
  KAKENHI-PROJECT-21791781
[Presentation] Induction of Treg from PBMC by interacting with immunosuppressive B7-H3 molecule on oral mesenchymal stem cells from human gingival fibroblasts.2009
- Author(s)
  Nagai Y., Shiraishi D., Ohki A., Tanaka Y., Aso H., Sugawara S.
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21791781
[Presentation] Analysis of antigen incorporating and processing cells in subling al immunotherapy2009
- Author(s)
  Shiraishi D., Nagai Y., Tanaka Y., Endo Y., Shimauchi H., Sugawara S
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21791781
[Presentation] 舌下粘膜の抗原取り込み機構と舌下粘膜免疫療法2009
- Author(s)
  白石大祐、永井康裕、遠藤康男、島内英俊、菅原俊二
- Organizer
  第51回歯科基礎医学会
- Place of Presentation
  新潟
- Year and Date
  2009-09-09
- Data Source
  KAKENHI-PROJECT-21791781
[Presentation] Induction of Treg from PBMC by interacting with immunosuppressive molecules B7-H3 on oral mesenchymal stem cells from human ginaival fibroblasts2009
- Author(s)
  Nagai Y, Kuroishi T, Ohki A, Sugawara S
- Organizer
  Interface Oral Health Science
- Place of Presentation
  仙台
- Year and Date
  2009-01-15
- Data Source
  KAKENHI-PROJECT-20890020
[Presentation] ヒト歯肉線維芽細胞からの間葉系幹細胞の樹立と共刺激分子の発現解析2009
- Author(s)
  永井康裕、黒石智誠、白石大祐、大木亜紀子、菅原俊二
- Organizer
  第50回歯科基礎医学会学術集会
- Place of Presentation
  東京
- Year and Date
  2009-09-23
- Data Source
  KAKENHI-PROJECT-20890020
[Presentation] Induction of Treg from PBMC by interacting with immunosuppressive molecules on oral mesenchvmal stem cells from human gingival fibroblasts2008
- Author(s)
  Nagai Y, Kuroishi T, Ohki A, Sugawara S
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-20890020
[Presentation] Induction of Treg from PBMC by interacting with immunosuppressive molecules on oral mesenchvmal stem cells from human gingival fibroblasts2008
- Author(s)
  Nagai Y, Kuroishi T, Ohki A, Sugawara S
- Organizer
  The American society for cell biology 48^<th> annual meetig
- Place of Presentation
  San Francisco, USA
- Year and Date
  2008-12-16
- Data Source
  KAKENHI-PROJECT-20890020

1. ENDO Yasuo (50005039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. YAMAGUCHI Kouji (10372319)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 横山政宣 (20396500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAGAI Yasuhiro 永井 康裕

Research Projects

Research Products

Co-Researchers

舌下免疫療法を利用した腸管炎症疾患への治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Bisphosphonate-induced jawbone necrosis : studies for its mechanism, prevention, and treatment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of diet-induced obesity and its immuno-defect on sublingual immunotherapy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

口腔粘膜の間葉系幹細胞が制御する免疫抑制機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pro-IL-1β accumulation in macrophages by alendronate and its prevention by clodronate.2010

Author(s)

Journal Title

Data Source

[Journal Article] Pro-IL-1β accumulation in macrophages by alendronate and its prevention by clodronate.2010

Author(s)

Journal Title

Data Source

[Journal Article] Pro-IL-1ss accumulation in macrophages by alendronate and its prevention by clodronate2010

Author(s)

Journal Title

Data Source

[Journal Article] Muramyldipeptide augments the actions of lipopolysaccharide in mice by stimulating macrophages to produce pro-IL-1 and by down-regulation of the suppressor of cytokine signaling 1 (SOCS1).2009

Author(s)

Journal Title

Data Source

[Journal Article] Biotin status affects nickel allergy via regulation of interleukin-1beta production in mice.2009

Author(s)

Journal Title

Data Source

[Journal Article] Biotin status affects nickel allergy via regulation of interleukin-1beta production in mice2009

Author(s)

Journal Title

Data Source

[Journal Article] Anterior Pituitary Progenitor Cells Express Costimulatory Molecule 4Ig-B7-H32008

Author(s)

Journal Title

Data Source

[Journal Article] Anterior pituitary progenitor cells that express IL-18 and IL-18Rs serve as immuno-endocrine modulators2008

Author(s)

Journal Title

Data Source

[Presentation] 骨吸収抑制作用とは関連しないbisphosphonates(BPs)の鎮痛作用.2010

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Histamine Reduces Susceptibility to NK Cells via Down-Regulation of NKG2D Ligand Expression on Human Monocytic Leukemia THP-1 Cells.2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Histamine Reduces Susceptibility to NK Cells via Down-Regulation of NKG2D Ligand Expression on Human Monocytic Leukemia THP-1 Cells2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Bisphosphonates(BPs)の炎症・壊死作用:マウス耳介皮膚での検討.2010

Author(s)

Organizer

NAGAI Yasuhiro 永井康裕