sohara eisei 蘇原映誠

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SOHARA Eisei 蘇原映誠

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Researcher Number	90510355
Other IDs
Affiliation (Current)	2025: 東京科学大学, 大学院医歯学総合研究科, 准教授
Affiliation (based on the past Project Information) *help	2024: 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 2016 – 2022: 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 2013 – 2014: 東京医科歯科大学, 医学部附属病院, 講師 2010 – 2012: 東京医科歯科大学, 医学部附属病院, 助教 2009: Tokyo Medical and Dental University, 医歯学総合研究科, 助教 2008: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教
Review Section/Research Field	Principal Investigator Kidney internal medicine / Basic Section 53040:Nephrology-related / Medium-sized Section 53:Organ-based internal medicine and related fields
Keywords	Principal Investigator 高血圧 / WNKキナーゼ / 塩分感受性高血圧 / 線維化 / 慢性腎臓病 / AMPK / 塩分感受性 / WNK / インスリン / NCC … More / 多発性嚢胞腎 / ネフロン癆 / 可視化 / 腎臓オルガノイド / CRISPR / 腎オルガノイド / 腎線維化 / エネルギー感受性 / リピドミクス / エネルギー代謝 / 臓器連関 / 蛋白制限食 / 治療薬開発 / AMP感受性 / エネルギー恒常性 / バイオマーカー / ゲノム / 網羅的遺伝子解析 / 次世代シークエンサー / PKA / 偽性低アルドステロン症２型 / 骨格筋 / メトホルミン / 蛋白分解系 / KLHL3 / リン / AQP2 / WNKシグナル / 肥満 / 水・電解質代謝学 / サイアザイド / メタボリック症候群 / 偽性低アルドステロン症 / SPAK / 塩分再吸収 / 水電解質 / NaCl共輸送体 Less

エネルギー感知機構の破綻による慢性腎臓病の線維化進行機序解明と治療法開発Principal Investigator
- Principal Investigator
  
  蘇原映誠
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Tokyo Medical and Dental University
腎オルガノイドを用いたForward Geneticによる腎線維化制御機構の探索Principal Investigator
- Principal Investigator
  
  蘇原映誠
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
Elucidation of molecular pathogenesis and development of novel therapeutic strategy of energy-sensing failure of AMPK in chronic kidney diseasePrincipal Investigator
- Principal Investigator
  
  SOHARA Eisei
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Tokyo Medical and Dental University
Elucidation of regulatory mechanism of WNK signal by protein degradation systemPrincipal Investigator
- Principal Investigator
  
  SOHARA Eisei
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University
Novel medical approach of polycystic kidney disease by the next generation sequencerPrincipal Investigator
- Principal Investigator
  
  SOHARA Eisei
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University
Development of order-made treatment of hypertension by measurement of urinary transportersPrincipal Investigator
- Principal Investigator
  
  SOHARA EISEI
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University
WNK kinase links insulin with salt-sensitive hypertensionPrincipal Investigator
- Principal Investigator
  
  SOHARA EISEI
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University
WNK kinase links salt-sensitive hypertension with obesityPrincipal Investigator
- Principal Investigator
  
  SOHARA Eisei
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University
Relationship between WNK kinase and hypertension in polycystic kidney diseasePrincipal Investigator
- Principal Investigator
  
  SOHARA Eisei
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University

[Book] 偽性低アルドステロン症II型2011
- Author(s)
  蘇原映
- Data Source
  KAKENHI-PROJECT-22790783
[Book] Handb Exp Pharmacol.2009
- Author(s)
  Sohara E, Uchida S, Sasaki S.
- Data Source
  KAKENHI-PROJECT-20890062
[Journal Article] NCC regulation by WNK signal cascade2023
- Author(s)
  Uchida Shinichi、Mori Takayasu、Susa Koichiro、Sohara Eisei
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 13 Pages: 1081261-1081261
- DOI
  10.3389/fphys.2022.1081261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19518, KAKENHI-PROJECT-21K08249, KAKENHI-PROJECT-23K24346
[Journal Article] Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression2023
- Author(s)
  Tomoki Yanagi, Hiroaki Kikuchi, Koichiro Susa, Naohiro Takahashi, Naohiro Takahashi, Hiroki Bamba, Takefumi Suzuki, Yuta Nakano, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Shintaro Mandai, Takayasu Mori, Koh Takeuchi, Shinya Honda, Satoru Torii, Shigeomi Shimizu, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara
- Journal Title
  
  Genes to Cells
  
  Volume: 28 Issue: 1 Pages: 5-14
- DOI
  10.1111/gtc.12989
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08223, KAKENHI-PROJECT-21K08249, KAKENHI-PROJECT-22K07345, KAKENHI-PROJECT-22K19518, KAKENHI-PROJECT-20H00467, KAKENHI-PROJECT-21K20710, KAKENHI-WRAPUP-22H04899, KAKENHI-PROJECT-23K19610, KAKENHI-PUBLICLY-22H04639, KAKENHI-PROJECT-20H03378
[Journal Article] Different Clinical Courses of Nephronophthisis in Dizygotic Twins2023
- Author(s)
  Oki Yutaro、Katsuma Ai、Okabe Masahiro、Watanabe Mao、Sagasaki Makoto、Takahashi Daisuke、Kimura Ai、Kato Junichiro、Ueda Hiroyuki、Hataya Hiroshi、Fujimaru Takuya、Mori Takayasu、Sohara Eisei、Uchida Shinichi、Miyazaki Yoichi、Yokoo Takashi
- Journal Title
  
  Intern. Med.
  
  Volume: 62 Issue: 1 Pages: 87-90
- DOI
  10.2169/internalmedicine.8707-21
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2023-01-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08249, KAKENHI-PROJECT-22K19518, KAKENHI-PROJECT-22K16233
[Journal Article] Generation of NPHP1 knockout human pluripotent stem cells by a practical biallelic gene deletion strategy using CRISPR/Cas9 and ssODN2022
- Author(s)
  Nakano Yuta、Susa Koichiro、Yanagi Tomoki、Hiraoka Yuichi、Suzuki Takefumi、Mori Takayasu、Ando Fumiaki、Mandai Shintaro、Fujiki Tamami、Rai Tatemitsu、Uchida Shinichi、Sohara Eisei
- Journal Title
  
  In Vitro Cellular & Developmental Biology - Animal
  
  Volume: 58 Issue: 2 Pages: 85-95
- DOI
  10.1007/s11626-022-00655-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01049, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-21K08223, KAKENHI-PROJECT-19H03672
[Journal Article] Genetic Background and Clinicopathologic Features of Adult-onset Nephronophthisis2021
- Author(s)
  Fujimaru Takuya、Kawanishi Kunio、et al.
- Journal Title
  
  Kidney International Reports
  
  Volume: 未定 Issue: 5 Pages: 1346-1354
- DOI
  10.1016/j.ekir.2021.02.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17730, KAKENHI-PROJECT-19K17699, KAKENHI-PROJECT-20K22926, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-20H03697, KAKENHI-PROJECT-21K08249, KAKENHI-PROJECT-19H03672
[Journal Article] Dietary Magnesium Insufficiency Induces Salt-Sensitive Hypertension in Mice Associated With Reduced Kidney Catechol-O-Methyl Transferase Activity2021
- Author(s)
  Kumagai Asako、Takeda Satoru、Sohara Eisei、Uchida Shinichi、Iijima Hiroshi、Itakura Astuo、Koya Daisuke、Kanasaki Keizo
- Journal Title
  
  Hypertension
  
  Volume: - Issue: 1 Pages: 138-150
- DOI
  10.1161/hypertensionaha.120.16377
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18175, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773
[Journal Article] Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney2021
- Author(s)
  Takahashi Naohiro、Kikuchi Hiroaki、Usui Ayaka、Furusho Taisuke、Fujimaru Takuya、Fujiki Tamami、Yanagi Tomoki、Matsuura Yoshiaki、Asano Kenichi、Yamamoto Kouhei、Ando Fumiaki、Susa Koichiro、Mandai Shintaro、Mori Takayasu、Rai Tatemitsu、Uchida Shinichi、Arita Makoto、Sohara Eisei
- Journal Title
  
  Clinical and Experimental Nephrology
  
  Volume: 25 Issue: 5 Pages: 445-455
- DOI
  10.1007/s10157-021-02021-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00495, KAKENHI-PROJECT-19H01049, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-21K06877, KAKENHI-PROJECT-21K16181, KAKENHI-PROJECT-21K20710, KAKENHI-PROJECT-19H03672
[Journal Article] Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A)2021
- Author(s)
  Nanamatsu Azuma、Mori Takayasu、Ando Fumiaki、Furusho Taisuke、Mandai Shintaro、Susa Koichiro、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Hypertension
  
  Volume: epub Issue: 6 Pages: 1953-1963
- DOI
  10.1161/hypertensionaha.121.17127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17733, KAKENHI-PROJECT-19H01049, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-21H02933, KAKENHI-PROJECT-21K08249, KAKENHI-PROJECT-19H03672
[Journal Article] The WNK signaling pathway and salt-sensitive hypertension2020
- Author(s)
  Furusho Taisuke、Uchida Shinichi、Sohara Eisei
- Journal Title
  
  Hypertension Research
  
  Volume: 43 Issue: 8 Pages: 733-743
- DOI
  10.1038/s41440-020-0437-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03672
[Journal Article] WNK1-TAK1 signaling suppresses lipopolysaccharide-induced cytokine production and classical activation in macrophages2020
- Author(s)
  Arai Yohei、Asano Kenichi、Mandai Shintaro、Ando Fumiaki、Susa Koichiro、Mori Takayasu、Nomura Naohiro、Rai Tatemitsu、Tanaka Masato、Uchida Shinichi、Sohara Eisei
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 533 Issue: 4 Pages: 1290-1297
- DOI
  10.1016/j.bbrc.2020.10.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-19K16686, KAKENHI-PROJECT-20H03473
[Journal Article] Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease2020
- Author(s)
  Furusho T, Sohara E, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Zeniya M, Mori T, Susa K, Isobe K, Nomura N, Yamamoto K, Okado T, Rai T, Uchida S
- Journal Title
  
  Kidney International
  
  Volume: 97 Issue: 4 Pages: 713-727
- DOI
  10.1016/j.kint.2019.11.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-19K21299, KAKENHI-PROJECT-20K17244, KAKENHI-PROJECT-20K17276, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672
[Journal Article] HPRT-related hyperuricemia with a novel p.V35M mutation in HPRT1 presenting familial juvenile gout.2020
- Author(s)
  Mishima E, Mori T, Nakajima Y, Toyohara T, Kikuchi K, Oikawa Y, Matsuhashi T, Maeda Y, Suzuki T, Kudo M, Ito S, Sohara E, Uchida S, Abe T.
- Journal Title
  
  CEN Case Rep
  
  Volume: pub Issue: 3 Pages: 210-214
- DOI
  10.1007/s13730-020-00459-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17733, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K08198, KAKENHI-PROJECT-19K23933
[Journal Article] Copy Number Variation: A?New Genetic Form of?Polycystic Kidney and Liver Disease2020
- Author(s)
  Fujimaru Takuya、Sohara Eisei
- Journal Title
  
  Kidney International Reports
  
  Volume: 5 Issue: 5 Pages: 575-576
- DOI
  10.1016/j.ekir.2020.03.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22926, KAKENHI-PROJECT-19H03672
[Journal Article] Nationwide in-hospital mortality following major fractures among hemodialysis patients and the general population: An observational cohort study2020
- Author(s)
  Mandai Shintaro、Sato Hidehiko、Iimori Soichiro、Naito Shotaro、Tanaka Haruna、Ando Fumiaki、Susa Koichiro、Isobe Kiyoshi、Mori Takayasu、Nomura Naohiro、Sohara Eisei、Okado Tomokazu、Uchida Shinichi、Fushimi Kiyohide、Rai Tatemitsu
- Journal Title
  
  Bone
  
  Volume: 130 Pages: 115122-115122
- DOI
  10.1016/j.bone.2019.115122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K15970
[Journal Article] Genetics May Predict Effectiveness of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease2020
- Author(s)
  Sekine Akinari、Hoshino Junichi、Fujimaru Takuya、Suwabe Tatsuya、Mizuno Hiroki、Kawada Masahiro、Hiramatsu Rikako、Hasegawa Eiko、Yamanouchi Masayuki、Hayami Noriko、Mandai Shintaro、Chiga Motoko、Kikuchi Hiroaki、Ando Fumiaki、Mori Takayasu、Sohara Eisei、Uchida Shinichi、Sawa Naoki、Takaichi Kenmei、Ubara Yoshifumi
- Journal Title
  
  American Journal of Nephrology
  
  Volume: 51 Issue: 9 Pages: 745-751
- DOI
  10.1159/000509817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22926, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K08227, KAKENHI-PROJECT-19K17733
[Journal Article] Phenotypic differences of mutation‐negative cases in Gitelman syndrome clinically diagnosed in adulthood2020
- Author(s)
  Mori Takayasu、Chiga Motoko、Fujimaru Takuya、Kawamoto Ryosuke、Mandai Shintaro、Nanamatsu Azuma、Nomura Naohiro、Ando Fumiaki、Susa Koichiro、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Human Mutation
  
  Volume: 42 Issue: 3 Pages: 300-309
- DOI
  10.1002/humu.24159
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22926, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-19K17733, KAKENHI-PROJECT-21K08249
[Journal Article] Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia2020
- Author(s)
  Shoda W, Nomura N, Ando F, Tagashira H, Iwamoto T, Ohta A, Isobe K, Mori T, Susa K, Sohara E, Rai T, Uchida S.
- Journal Title
  
  PLoS One.
  
  Volume: 15(6) Issue: 6 Pages: 0235360-0235360
- DOI
  10.1371/journal.pone.0235360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16509, KAKENHI-PROJECT-20K17244, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-19K23982
[Journal Article] 慢性腎臓病におけるエネルギー不全状態の解明とその治療の探索2019
- Author(s)
  菊池寛昭, 蘇原映誠
- Journal Title
  
  腎と透析
  
  Volume: 86 Pages: 629-633
- Data Source
  KAKENHI-PROJECT-19H03672
[Journal Article] Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease2019
- Author(s)
  Kikuchi H, Sasaki E, Nomura N, Mori T, Minamishima YA, Yoshizaki Y, Takahashi N, Furusho T, Arai Y, Mandai S, Yamashita T, Ando F, Maejima Y, Isobe K, Okado T, Rai T, Uchida S, Sohara E
- Journal Title
  
  Kidney international
  
  Volume: 95 Issue: 1 Pages: 123-137
- DOI
  10.1016/j.kint.2018.08.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-16H04723
[Journal Article] Complete clinical resolution of a Japanese family with renal pseudohypoaldosteronism type 1 due to a novel NR3C2 mutation.2019
- Author(s)
  Tanaka T, Oki E, Mori T, Tsuruga K, Sohara E, Uchida S, Tanaka H.
- Journal Title
  
  Nephrology (Carlton)
  
  Volume: 24 Issue: 4 Pages: 489-490
- DOI
  10.1111/nep.13391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H06657, KAKENHI-PROJECT-19K17733, KAKENHI-PROJECT-19H03672
[Journal Article] Genotype-Clinical Correlations in Polycystic Kidney Disease with No Apparent Family History2019
- Author(s)
  Sekine Akinari、Fujimaru Takuya、Hoshino Junichi、Suwabe Tatsuya、Oguro Masahiko、Mizuno Hiroki、Kawada Masahiro、Sumida Keiichi、Hiramatsu Rikako、Chiga Motoko、Kikuchi Hiroaki、Ando Fumiaki、Mori Takayasu、Sohara Eisei、Uchida Shinichi、Sawa Naoki、Takaichi Kenmei、Ubara Yoshifumi
- Journal Title
  
  American Journal of Nephrology
  
  Volume: 49 Issue: 3 Pages: 233-240
- DOI
  10.1159/000497444
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-17H06657, KAKENHI-PROJECT-18K08227, KAKENHI-PROJECT-19K17733, KAKENHI-PROJECT-19H03672
[Journal Article] 遺伝性高血圧から Precision Medicine を考える2019
- Author(s)
  正田若菜, 蘇原映誠
- Journal Title
  
  血圧
  
  Volume: 26 Pages: 21-24
- Data Source
  KAKENHI-PROJECT-19H03672
[Journal Article] 慢性腎臓病におけるエネルギー枯渇の感知障害2019
- Author(s)
  菊池寛昭, 蘇原映誠
- Journal Title
  
  医学のあゆみ
  
  Volume: 269 Pages: 934-939
- Data Source
  KAKENHI-PROJECT-19H03672
[Journal Article] A case of Gitelman syndrome: our experience with a patient treated in clinical practice on a local island2019
- Author(s)
  Chinen Takashi、Saeki Eiji、Mori Takayasu、Sohara Eisei、Uchida Shinichi、Akimoto Tetsu
- Journal Title
  
  J Rural Med
  
  Volume: 14 Issue: 2 Pages: 258-262
- DOI
  10.2185/jrm.3014
- NAID
  130007748822
- ISSN
  1880-487X, 1880-4888
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17733, KAKENHI-PROJECT-19H03672
[Journal Article] Non-urate transporter 1, non-glucose transporter member 9-related renal hypouricemia and acute renal failure accompanied by hyperbilirubinemia after anaerobic exercise: a case report2019
- Author(s)
  Furuto Yoshitaka、Kawamura Mariko、Namikawa Akio、Takahashi Hiroko、Shibuya Yuko、Mori Takayasu、Sohara Eisei
- Journal Title
  
  BMC Nephrology
  
  Volume: 20 Issue: 1 Pages: 433-433
- DOI
  10.1186/s12882-019-1618-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17733, KAKENHI-PROJECT-19H03672
[Journal Article] Tacrolimus ameliorates the phenotypes of type 4 Bartter syndrome model mice through activation of sodium?potassium?2 chloride cotransporter and sodium?chloride cotransporter2019
- Author(s)
  Matsuura Yoshiaki、Nomura Naohiro、Shoda Wakana、Mori Takayasu、Isobe Kiyoshi、Susa Koichiro、Ando Fumiaki、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 517 Issue: 2 Pages: 364-368
- DOI
  10.1016/j.bbrc.2019.07.086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995
[Journal Article] Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation2019
- Author(s)
  Fujiki Tamami、Ando Fumiaki、Murakami Kana、Isobe Kiyoshi、Mori Takayasu、Susa Koichiro、Nomura Naohiro、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 9245-9245
- DOI
  10.1038/s41598-019-45539-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16501, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970
[Journal Article] A familial case of pseudohypoaldosteronism type II (PHA2) with a novel mutation (D564N) in the acidic motif in WNK4.2019
- Author(s)
  Sakoh T, Sekine A, Mori T, Mizuno H, Kawada M, Hiramatsu R, Hasegawa E, Hayami N, Yamanouchi M, Suwabe T, Sawa N, Ubara Y, Fujimaru T, Sohara E, Shinichi U, Hoshino J, Takaichi K.
- Journal Title
  
  Mol Genet Genomic Med
  
  Volume: 1 Issue: 6
- DOI
  10.1002/mgg3.705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H06657, KAKENHI-PROJECT-19K17733, KAKENHI-PROJECT-19H03672
[Journal Article] Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium-chloride cotransporter2018
- Author(s)
  Hashimoto Hiroko、Nomura Naohiro、Shoda Wakana、Isobe Kiyoshi、Kikuchi Hiroaki、Yamamoto Kouhei、Fujimaru Takuya、Ando Fumiaki、Mori Takayasu、Okado Tomokazu、Rai Tatemitsu、Uchida Shinichi、Sohara Eisei
- Journal Title
  
  Metabolism
  
  Volume: 85 Pages: 23-31
- DOI
  10.1016/j.metabol.2018.02.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314
[Journal Article] AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus2018
- Author(s)
  Ando Fumiaki、Mori Shuichi、Yui Naofumi、Morimoto Tetsuji、Nomura Naohiro、Sohara Eisei、Rai Tatemitsu、Sasaki Sei、Kondo Yoshiaki、Kagechika Hiroyuki、Uchida Shinichi
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1411-1411
- DOI
  10.1038/s41467-018-03771-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-15K09286, KAKENHI-PROJECT-18K08233, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-17H06656, KAKENHI-PROJECT-15K09301, KAKENHI-PROJECT-16K09642
[Journal Article] Kidney enlargement and multiple liver cyst formation implicate mutations in PKD1/2 in adult sporadic polycystic kidney disease2018
- Author(s)
  Fujimaru T.、Mori T.、Sekine A.、Mandai S.、Chiga M.、Kikuchi H.、Ando F.、Mori Y.、Nomura N.、Iimori S.、Naito S.、Okado T.、Rai T.、Hoshino J.、Ubara Y.、Uchida S.、Sohara E.
- Journal Title
  
  Clinical Genetics
  
  Volume: 印刷中 Issue: 1 Pages: 125-131
- DOI
  10.1111/cge.13249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-16H05314
[Journal Article] Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo2018
- Author(s)
  Yoshida S, Araki Y, Mori T, Sasaki E, Kasagi Y, Isobe K, Susa K, Inoue Y, Bomont P, Okado T, Rai T, Uchida S, Sohara E
- Journal Title
  
  Clinical and experimental nephrology
  
  Volume: 22 Issue: 6 Pages: 1251-1257
- DOI
  10.1007/s10157-018-1593-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16K09642
[Journal Article] WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO42018
- Author(s)
  Mandai S, Mori T, Nomura N, Furusho T, Arai Y, Kikuchi H, Sasaki E, Sohara E, Rai T, Uchida S
- Journal Title
  
  Scientific reports
  
  Volume: 8 Issue: 1 Pages: 9101-9101
- DOI
  10.1038/s41598-018-27414-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-19K21299, KAKENHI-PROJECT-16K09642
[Journal Article] Role of ClC-K and barttin in low potassium-induced sodium chloride cotransporter activation and hypertension in mouse kidney2018
- Author(s)
  Nomura Naohiro、Shoda Wakana、Wang Yuanlong、Mandai Shintaro、Furusho Taisuke、Takahashi Daiei、Zeniya Moko、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Bioscience Reports
  
  Volume: 38 Issue: 1 Pages: 20171243-1243
- DOI
  10.1042/bsr20171243
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16K19478, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-17K16076, KAKENHI-PROJECT-17K16077
[Journal Article] WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL32017
- Author(s)
  Susa Koichiro、Sohara Eisei、Takahashi Daiei、Okado Tomokazu、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 491 Issue: 3 Pages: 727-732
- DOI
  10.1016/j.bbrc.2017.07.121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16K15467
[Journal Article] Calcineurin inhibitors block sodium-chloride cotransporter dephosphorylation in response to high potassium intake.2017
- Author(s)
  Shoda W, Nomura N, Ando F, Mori Y, Mori T, Sohara E, Rai T, Uchida S.
- Journal Title
  
  Kidney Int.
  
  Volume: 91 Issue: 2 Pages: 402-411
- DOI
  10.1016/j.kint.2016.09.001
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16H06772, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-16K19478
[Journal Article] The proteasome inhibitor bortezomib attenuates renal fibrosis in mice via the suppression of TGF-β12017
- Author(s)
  Zeniya Moko、Mori Takayasu、Yui Naofumi、Nomura Naohiro、Mandai Shintaro、Isobe Kiyoshi、Chiga Motoko、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 13086-13086
- DOI
  10.1038/s41598-017-13486-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16076, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16K15467
[Journal Article] Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice.2017
- Author(s)
  Kasagi Y, Takahashi D, Aida T, Nishida H, Nomura N, Zeniya M, Mori T, Sasaki E, Ando F, Rai T, Uchida S, Sohara E.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 487 Issue: 2 Pages: 368-374
- DOI
  10.1016/j.bbrc.2017.04.068
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15H06183, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-16K07085, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-17K16076, KAKENHI-PROJECT-16K19478
[Journal Article] KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3.2017
- Author(s)
  Sasaki E, Susa K, Mori T, Isobe K, Araki Y, Inoue Y, Yoshizaki Y, Ando F, Mori Y, Mandai S, Zeniya M, Takahashi D, Nomura N, Rai T, Uchida S, Sohara E.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 27 Issue: 7 Pages: 1-13
- DOI
  10.1128/mcb.00508-16
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15H06183, KAKENHI-PROJECT-16H06772, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K19446, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-17K16076
[Journal Article] Comprehensive genetic testing approach for major inherited kidney diseases, using next-generation sequencing with a custom panel2017
- Author(s)
  Mori T, Hosomichi K, Chiga M, Mandai S, Nakaoka H, Sohara E, Okado T, Rai T, Sasaki S, Inoue I, Uchida S.
- Journal Title
  
  Clin Exp Nephrol.
  
  Volume: 印刷中 Issue: 1 Pages: 63-75
- DOI
  10.1007/s10157-016-1252-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06502, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-26430195, KAKENHI-PROJECT-15K19446, KAKENHI-PROJECT-16K15467
[Journal Article] Salt suppresses IFNγ inducible chemokines through the IFNγ-JAK1-STAT1 signaling pathway in proximal tubular cells.2017
- Author(s)
  Arai Y, Takahashi D, Asano K, Tanaka M, Oda M, Ko SBH, Ko MSH, Mandai S, Nomura N, Rai T, Uchida S, Sohara E.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 46580-46580
- DOI
  10.1038/srep46580
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15K14431, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-16K09642, KAKENHI-PLANNED-26110006, KAKENHI-PROJECT-15H04812, KAKENHI-PROJECT-17H04068
[Journal Article] Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy2017
- Author(s)
  Yoshizaki Yuki、Mori Takayasu、Ishigami-Yuasa Mari、Kikuchi Eriko、Takahashi Daiei、Zeniya Moko、Nomura Naohiro、Mori Yutaro、Araki Yuya、Ando Fumiaki、Mandai Shintaro、Kasagi Yuri、Arai Yohei、Sasaki Emi、Yoshida Sayaka、Kagechika Hiroyuki、Rai Tatemitsu、Uchida Shinichi、Sohara Eisei
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 3945-3945
- DOI
  10.1038/s41598-017-04233-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16076, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16K15467
[Journal Article] WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice.2017
- Author(s)
  Takahashi D, Mori T, Sohara E, Tanaka M, Chiga M, Inoue Y, Nomura N, Zeniya M, Ochi H, Takeda S, Suganami T, Rai T, Uchida S.
- Journal Title
  
  EBioMedicine
  
  Volume: 18 Pages: 118-27
- DOI
  10.1016/j.ebiom.2017.03.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01633, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15H06183, KAKENHI-PROJECT-15H06184, KAKENHI-PROJECT-26713048, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K15545, KAKENHI-PROJECT-15K19446, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-17K16076, KAKENHI-PROJECT-17K16077, KAKENHI-PUBLICLY-17H05500, KAKENHI-PROJECT-15K09423, KAKENHI-PROJECT-16K15234
[Journal Article] Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy.2017
- Author(s)
  Mandai S, Furukawa S, Kodaka M, Hata Y, Mori T, Nomura N, Ando F, Mori Y, Takahashi D, Yoshizaki Y, Kasagi Y, Arai Y, Sasaki E, Yoshida S, Furuichi Y, Fujii NL, Sohara E, Rai T, Uchida S.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 46369-46369
- DOI
  10.1038/srep46369
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-26293061, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K16489, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-16K09642
[Journal Article] Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway.2016
- Author(s)
  Ando F, Sohara E, Morimoto T, Yui N, Nomura N, Kikuchi E, Takahashi D, Mori T, Vandewalle A, Rai T, Sasaki S, Kondo Y, Uchida S.
- Journal Title
  
  Nat Commun.
  
  Volume: 7 Issue: 1 Pages: 13636-13636
- DOI
  10.1038/ncomms13636
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K09286, KAKENHI-PROJECT-15K09301, KAKENHI-PROJECT-16K15467
[Journal Article] Effects of diuretics on sodium-dependent glucose cotransporter 2 inhibitor-induced changes in blood pressure in obese rats suffering from the metabolic syndrome.2016
- Author(s)
  Rahman A, Kittikulsuth W, Fujisawa Y, Sufiun A, Rafiq K, Hitomi H, Nakano D, Sohara E, Uchida S, Nishiyama A.
- Journal Title
  
  J Hypertens.
  
  Volume: 34 Issue: 5 Pages: 893-906
- DOI
  10.1097/hjh.0000000000000871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-26460343, KAKENHI-PROJECT-15K09266
[Journal Article] Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder.2016
- Author(s)
  Sohara E, Uchida S.
- Journal Title
  
  Nephrol Dial Transplant.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670428
[Journal Article] Comprehensive genetic testing approach for major inherited kidney diseases, using next-generation sequencing with a custom panel.2016
- Author(s)
  Mori T, Hosomichi K, Chiga M, Mandai S, Nakaoka H, Sohara E, Okado T, Rai T, Sasaki S, Inoue I, Uchida S.
- Journal Title
  
  Clin Exp Nephrol.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670428
[Journal Article] Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3.2015
- Author(s)
  Yoshizaki Y, Mori Y, Tsuzaki Y, Mori T, Nomura N, Wakabayashi M, Takahashi D, Zeniya M, Kikuchi E, Araki Y, Ando F, Isobe K, Nishida H, Ohta A, Susa K, Inoue Y, Chiga M, Rai T, Sasaki S, Uchida S, Sohara E.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 467 Issue: 2 Pages: 229-234
- DOI
  10.1016/j.bbrc.2015.09.184
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K19446, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25461243, KAKENHI-PROJECT-26670428, KAKENHI-PROJECT-15K19445, KAKENHI-PROJECT-26860628, KAKENHI-PROJECT-26860629
[Journal Article] Associated STK39 Polymorphism Knockin Cell Lines With the Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 System.2015
- Author(s)
  Mandai S, Mori T, Sohara E, Rai T, Uchida S.
- Journal Title
  
  Hypertension
  
  Volume: 66 Issue: 6 Pages: 1199-1206
- DOI
  10.1161/hypertensionaha.115.05872
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-26670428
[Journal Article] Generation and analysis of knock-in mice carrying pseudohypoaldosteronism type II-causing mutations in the cullin 3 gene.2015
- Author(s)
  Araki Y, Rai T, Sohara E, Mori T, Inoue Y, Isobe K, Kikuchi E, Ohta A, Sasaki S, Uchida S.
- Journal Title
  
  Biol Open
  
  Volume: 4 Issue: 11 Pages: 1509-1517
- DOI
  10.1242/bio.013276
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K19446, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25461243, KAKENHI-PROJECT-26670428
[Journal Article] Dynamic subcellular localization of aquaporin-7 in white adipocytes.2015
- Author(s)
  Miyauchi T, Yamamoto H, Abe Y, Yoshida GJ, Rojek A, Sohara E, Uchida S, Nielsen S, Yasui M.
- Journal Title
  
  FEBS Lett
  
  Volume: 589 Issue: 5 Pages: 608-14
- DOI
  10.1016/j.febslet.2015.01.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670428, KAKENHI-PROJECT-26893062, KAKENHI-PROJECT-15J02898
[Journal Article] Involvement of selective autophagy mediated by p62/SQSTM1 in KLHL3-dependent WNK4 degradation.2015
- Author(s)
  Mori Y, Mori T, Wakabayashi M, Yoshizaki Y, Zeniya M, Sohara E, Rai T, Uchida S.
- Journal Title
  
  Biochem J.
  
  Volume: 472 Issue: 1 Pages: 33-41
- DOI
  10.1042/bj20150500
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-26670428, KAKENHI-PROJECT-26860629
[Journal Article] Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus2015
- Author(s)
  Zeniya M, Morimoto N, Takahashi D, Mori Y, Mori T, Ando F, Araki Y, Yoshizaki Y, Inoue Y, Isobe K, Nomura N, Oi K, Nishida H, Sasaki S, Sohara E, Rai T, Uchida S
- Journal Title
  
  J Am Soc Nephrol
  
  Volume: 26 Issue: 9 Pages: 2129-2138
- DOI
  10.1681/asn.2014070639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K19446, KAKENHI-PROJECT-26670428, KAKENHI-PROJECT-26860628
[Journal Article] WNK4 is the major WNK kinase positively regulating NCC in the mouse kidney2014
- Author(s)
  Takahashi D, Mori T, Nomura N, Khan MZ, Araki Y, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S
- Journal Title
  
  Biosci Rep
  
  Volume: 34 (3) Issue: 3 Pages: 195-205
- DOI
  10.1042/bsr20140047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-26670428
[Journal Article] Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters2014
- Author(s)
  Kikuchi E, Mori T, Zeniya M, Isobe K, Ishigami-Yuasa M, Fujii S, Kagechika H, Ishihara T, Mizushima T, Sasaki S, Sohara E, Rai T, Uchida S
- Journal Title
  
  J Am Soc Nephrol
  
  Volume: 26 Issue: 7 Pages: 1525-1536
- DOI
  10.1681/asn.2014060560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-25460146, KAKENHI-PROJECT-26670428
[Journal Article] Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice2014
- Author(s)
  Susa K, Sohara E, Rai T, Zeniya M, Mori Y, Mori T, Chiga M, Nomura N, Nishida H, Takahashi D, Isobe K, Inoue Y, Takeishi K, Takeda N, Sasaki S, Uchida S
- Journal Title
  
  Hum Mol Genet
  
  Volume: 23 (19) Issue: 19 Pages: 5052-60
- DOI
  10.1093/hmg/ddu217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-26670428, KAKENHI-PROJECT-26860628, KAKENHI-PROJECT-221S0001
[Journal Article] Aberrant Glycosylation and Localization of Polycystin-1 Cause Polycystic Kidney in an AQP11 Knockout Model.2014
- Author(s)
  Inoue Y, Sohara E, Kobayashi K, Chiga M, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S.
- Journal Title
  
  J Am Soc Nephrol.
  
  Volume: 25 Issue: 12 Pages: 2789-2799
- DOI
  10.1681/asn.2013060614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591243, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-26670428
[Journal Article] Regulation of with-no-lysine kinase signaling by Kelch-like proteins2014
- Author(s)
  Uchida S, Sohara E, Rai T, Sasaki S
- Journal Title
  
  Biol Cell
  
  Volume: 106(2) Issue: 2 Pages: 45-56
- DOI
  10.1111/boc.201300069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
[Journal Article] Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II2013
- Author(s)
  Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, Oi K, Chiga M, Takahashi D, Yang SS, Lin SH, Rai T, Sasaki S, Uchida S
- Journal Title
  
  Hypertension
  
  Volume: 62(5) Issue: 5 Pages: 872-8
- DOI
  10.1161/hypertensionaha.113.01543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-23590319, KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PUBLICLY-25136722, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25460350, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-25860670
[Journal Article] KLHL2 interacts with and ubiquitinates WNK kinases2013
- Author(s)
  Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 437(3) Issue: 3 Pages: 457-62
- DOI
  10.1016/j.bbrc.2013.06.104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
[Journal Article] Immunolocalization and translocation of aquaporin-5 water channel in sweat glands.2013
- Author(s)
  Inoue R, Sohara E, Rai T, Satoh T, Yokozeki H, Sasaki S, Uchida S.
- Journal Title
  
  J Dermatol Sci.
  
  Volume: 70 Issue: 1 Pages: 26-33
- DOI
  10.1016/j.jdermsci.2013.01.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
[Journal Article] Development of enzyme-linked immunosorbent assays for urinary thiazide-sensitive Na-Cl cotransporter (NCC) measurement2013
- Author(s)
  Isobe K, Mori T, Asano T, Kawaguchi H, Nonoyama S, Kumagai N, Kamada F, Morimoto T, Hayashi M, Sohara E, Rai T, Sasaki S, Uchida S
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 305(9) Issue: 9 Pages: F1374-F1381
- DOI
  10.1152/ajprenal.00208.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-24790836
[Journal Article] Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.2013
- Author(s)
  Mori, T.; Kikuchi, E.; Watanabe, Y.; Fujii, S.; Ishigami-Yuasa, M.; Kagechika, H.; Sohara, E.; Rai, T.; Sasaki, S.; Uchida, S.
- Journal Title
  
  Biochem. J.
  
  Volume: 455 Issue: 3 Pages: 339-345
- DOI
  10.1042/bj20130597
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136013, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25460146, KAKENHI-PROJECT-25670406
[Journal Article] Treatment with 17-allylamino-17-demethoxygeldanamycin ameliorated symptoms of Bartter syndrome type caused by mutated Bsnd in mice.2013
- Author(s)
  Nomura N, Kamiya K, Ikeda K, Yui N, Chiga M, Sohara E, Rai T, Sasaki S, Uchida S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 441 Issue: 3 Pages: 544-49
- DOI
  10.1016/j.bbrc.2013.10.129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25293351, KAKENHI-PROJECT-25462653, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-25670721
[Journal Article] Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms2013
- Author(s)
  Mori Y, Wakabayashi M, Mori T, Araki Y, Sohara E, Rai T, Sasaki S, Uchida S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 439(1) Issue: 1 Pages: 30-4
- DOI
  10.1016/j.bbrc.2013.08.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
[Journal Article] Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.2013
- Author(s)
  Wakabayashi M
- Journal Title
  
  Cell Rep.
  
  Volume: 28 Issue: 3 Pages: 858-868
- DOI
  10.1016/j.celrep.2013.02.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
[Journal Article] Severe hyperparathyroidism in a pre-dialysis chronic kidney disease patient treated with a very low protein diet2012
- Author(s)
  Ohta E, Akazawa M, Noda Y, Mandai S, Naito S, Ohta A, Sohara E, Okado T, Rai T, Uchida S, Sasaki S.
- Journal Title
  
  Bone Miner Metab
  
  Volume: 30(2) Pages: 238-42
- NAID
  10031168775
- Data Source
  KAKENHI-PROJECT-22790783
[Journal Article] A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo2012
- Author(s)
  Oi K
- Journal Title
  
  Biology Open
  
  Volume: Vol.1 Issue: 2 Pages: 120-127
- DOI
  10.1242/bio.2011048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-23659439, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836
[Journal Article] Does a β2-adrenergic receptor-WNK4-Na-Cl co-transporter signal cascade exist in the in vivo kidney?2012
- Author(s)
  Uchida S
- Journal Title
  
  Nat. Med.
  
  Volume: 18 Issue: 9 Pages: 1324-1325
- DOI
  10.1038/nm.2809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-23659439, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836
[Journal Article] Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice.2012
- Author(s)
  Nishida H
- Journal Title
  
  Hypertension
  
  Volume: 60 Issue: 4 Pages: 981-990
- DOI
  10.1161/hypertensionaha.112.201509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-23659439, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836
[Journal Article] Effect of heterozygous deletion of WNK1 on the WNK-OSR1/SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels2012
- Author(s)
  Susa K, Kita S, Iwamoto T, Yang SS, Lin SH, Ohta A, Sohara E, Rai T, Sasaki S, Alessi DR, Uchida S.
- Journal Title
  
  Clin Exp Nephrol
- NAID
  10031058026
- Data Source
  KAKENHI-PROJECT-22790783
[Journal Article] Effect of heterozygous deletion of WNK1 on the WNK-OSR1/SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.2012
- Author(s)
  Susa K, Kita S, Iwamoto T, Yang SS, Lin SH, Ohta A, Sohara E, Rai T, Sasaki S, Alessi DR, Uchida S.
- Journal Title
  
  Clin Exp Nephrol
  
  Volume: 16(4) Issue: 4 Pages: 530-538
- DOI
  10.1007/s10157-012-0590-x
- NAID
  10031058026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590254, KAKENHI-PROJECT-22790783, KAKENHI-PROJECT-23590319, KAKENHI-PROJECT-24790836
[Journal Article] Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination.2012
- Author(s)
  Hossain Khan MZ
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 425 Issue: 2 Pages: 456-461
- DOI
  10.1016/j.bbrc.2012.07.124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-23659439, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836
[Journal Article] WNK-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone.2012
- Author(s)
  Susa K
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 427 Issue: 4 Pages: 743-747
- DOI
  10.1016/j.bbrc.2012.09.130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-23659439, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836
[Journal Article] Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells.2012
- Author(s)
  Hara-Chikuma M
- Journal Title
  
  FASEB J.
  
  Volume: 26 Issue: 1 Pages: 211-218
- DOI
  10.1096/fj.11-186627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-21591463, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22790783, KAKENHI-PLANNED-23116101, KAKENHI-PROJECT-23659439, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836
[Journal Article] A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo2012
- Author(s)
  Oi K, Sohara E, Rai T, Misawa M, Chiga M, Alessi DR, Sasaki S, Uchida S.
- Journal Title
  
  Biology Open
  
  Volume: 1 Pages: 120-127
- Data Source
  KAKENHI-PROJECT-22790783
[Journal Article] Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells2012
- Author(s)
  Hara-Chikuma M, Sugiyama Y, Kabashima K, Sohara E, Uchida S, Sasaki S, Inoue S, Miyachi Y. FASEB J.
- Volume
  26(1)
- Pages
  211-8
- Data Source
  KAKENHI-PROJECT-22790783
[Journal Article] Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade2011
- Author(s)
  Chiga M
- Journal Title
  
  J. Cell Sci.
  
  Volume: Vol.124 Issue: 9 Pages: 1391-5
- DOI
  10.1242/jcs.084111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-22790783, KAKENHI-PROJECT-23659439
[Journal Article] Severe hyperparathyroidism in a pre-dialysis chronic kidney disease patient treated with a very low protein diet2011
- Author(s)
  Ohta E
- Journal Title
  
  J. Bone Miner. Metab.
  
  Volume: (published online) Issue: 2 Pages: 238-242
- DOI
  10.1007/s00774-011-0320-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-21591053, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22790783, KAKENHI-PROJECT-23659439, KAKENHI-PROJECT-24390215, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836
[Journal Article] Regulation of WNK1 kinase by extracellular potassium2011
- Author(s)
  Naito S
- Journal Title
  
  Clin. Exp. Nephrol.
  
  Volume: Vol.15 Issue: 2 Pages: 195-202
- DOI
  10.1007/s10157-010-0378-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-22790783, KAKENHI-PROJECT-23659439
[Journal Article] Generation and analyses of R8L barttin knockin mouse2011
- Author(s)
  Nomura N
- Journal Title
  
  Am. J. Physiol. Renal. Physiol.
  
  Volume: Vol.301 Issue: 2 Pages: F297-F307
- DOI
  10.1152/ajprenal.00604.2010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22790783
[Journal Article] Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney2011
- Author(s)
  Sohara E
- Journal Title
  
  PLoS One
  
  Volume: Vol.6 Issue: 8 Pages: e24277-e24277
- DOI
  10.1371/journal.pone.0024277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-22790783, KAKENHI-PROJECT-23659439
[Journal Article] Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney2011
- Author(s)
  Sohara E, Rai T, Yang SS, Ohta A, Naito S, Chiga M, Nomura N, Lin SH, Vandewalle A, Ohta E, Sasaki S, Uchida S.
- Journal Title
  
  PLoS One
  
  Volume: 6(8)
- Data Source
  KAKENHI-PROJECT-22790783
[Journal Article] Generation and analyses of R8L barttin knockin mouse2011
- Author(s)
  Nomura N, Tajima M, Sugawara N, Morimoto T, Kondo Y, Ohno M, Uchida K, Mutig K, Bachmann S, Soleimani M, Ohta E, Ohta A, Sohara E, Okado T, Rai T, Jentsch TJ, Sasaki S, Uchida S.
- Journal Title
  
  Am J Physiol RenalPhysiol
  
  Volume: 301(2)
- Data Source
  KAKENHI-PROJECT-22790783
[Journal Article] Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome2011
- Author(s)
  Lin SH
- Journal Title
  
  Proc. Natl. Acad. Sci. USA.
  
  Volume: Vol.108 Issue: 42 Pages: 17538-43
- DOI
  10.1073/pnas.1107452108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22790783, KAKENHI-PROJECT-23659439
[Journal Article] Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.2011
- Author(s)
  Chiga M, Rafiqi FH, Alessi DR, Sohara E, Ohta A, Rai T, Sasaki S, Uchida S.
- Journal Title
  
  J Cell Sci
  
  Volume: 124(Pt9) Pages: 1391-5
- Data Source
  KAKENHI-PROJECT-22790783
[Journal Article] Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome2011
- Author(s)
  Lin SH, Yu IS, Jiang ST, Lin SW, Chu P, Chen A, Sytwu HK, Sohara E, Uchida S, Sasaki S, Yang SS.
- Journal Title
  
  Natl Acad Sci USA
  
  Volume: 108(42) Pages: 17538-43
- Data Source
  KAKENHI-PROJECT-22790783
[Journal Article] Regulation of WNK1 kinase by extracellular potassium2011
- Author(s)
  Naito S, Ohta A, Sohara E, Ohta E, Rai T, Sasaki S, Uchida S.
- Journal Title
  
  Clin Exp Nephrol
  
  Volume: 15(2) Pages: 195-202
- NAID
  10029005115
- Data Source
  KAKENHI-PROJECT-22790783
[Journal Article] Aquaporins in kidney pathophysiology2010
- Author(s)
  Noda Y, Sohara E, Ohta E, Sasaki S.
- Journal Title
  
  Nat Rev Nephrol. 6(3)
  
  Pages: 168-78
- Data Source
  KAKENHI-PROJECT-20890062
[Journal Article] Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney.2010
- Author(s)
  Talati G, Ohta A, Rai T, 蘇原映誠, Naito S, Vandewalle A, Sasaki S, Uchida S.
- Journal Title
  
  Biochem Biophys Res Commun. 393
  
  Pages: 844-848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890062
[Journal Article] Aquaporins in kidney pathophysiology.2010
- Author(s)
  Noda Y, 蘇原映誠, Ohta E, Sasaki S.
- Journal Title
  
  Nat Rev Nephrol. 6
  
  Pages: 168-178
- Data Source
  KAKENHI-PROJECT-20890062
[Journal Article] Calcium-alkali syndrome-like symptoms manifested by daily alphacalcidol and thiazide2010
- Author(s)
  Satoh F, Okado T, Iwamoto M, Akita W, Wakabayashi M, Ohta A, Sohara E, Noda Y, Rai T, Uchida S, Sasaki S.
- Journal Title
  
  Intern Med. 49(9)
  
  Pages: 837-40
- NAID
  130000251882
- Data Source
  KAKENHI-PROJECT-20890062
[Journal Article] Aquaporins in kidney pathophysiology2010
- Author(s)
  Noda Y, Sohara E, Ohta E, Sasaki S
- Journal Title
  
  Nat Rev Nephrol
  
  Volume: 6 Pages: 168-178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790783
[Journal Article] Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney2010
- Author(s)
  Talati G, Ohta A, Rai T, Sohara E, Naito S, Vandewalle A, Sasaki S, Uchida S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 393 Pages: 844-848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790783
[Journal Article] Calcium-alkali syndrome-like symptoms manifested by daily alphacalcidol and thiazide.2010
- Author(s)
  Satoh F, Okado T, Iwamoto M, Akita W, Wakabayashi M, Ohta A, Sohara E, Noda Y, Rai T, Uchida S, Sasaki S
- Journal Title
  
  Intern Med
  
  Volume: 49 Pages: 837-840
- NAID
  130000251882
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790783
[Journal Article] 嚢胞性腎疾患とNek82010
- Author(s)
  蘇原映誠
- Journal Title
  
  医学のあゆみ 232
  
  Pages: 397-400
- Data Source
  KAKENHI-PROJECT-20890062
[Journal Article] Regulation of WNK1 kinase by extracellular potassium2010
- Author(s)
  Naito S, Ohta A, Sohara E, Ohta E, Rai T, Sasaki S, Uchida S
- Journal Title
  
  Clin Exp Nephrol
  
  Volume: (in press)
- NAID
  10029005115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790783
[Journal Article] Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney2010
- Author(s)
  Talati G, Ohta A, Rai T, Sohara E, Naito S, Vandewalle A, Sasaki S, Uchida S.
- Journal Title
  
  Biochem Biophys Res Commun. 393(4)
  
  Pages: 844-8
- Data Source
  KAKENHI-PROJECT-20890062
[Journal Article] 遺伝性腎性尿崩症～アクアポリン水チャネルによる尿濃縮機構とその破綻2009
- Author(s)
  蘇原映誠
- Journal Title
  
  実験医学 27
  
  Pages: 589-594
- Data Source
  KAKENHI-PROJECT-20890062
[Journal Article] EAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells.2009
- Author(s)
  Yui N, Okutsu R, Sohara E, Rai T, Ohta A, Noda Y, Sasaki S, Uchida S.
- Journal Title
  
  Am J Physiol Cell Physiol. 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890062
[Journal Article] Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure2009
- Author(s)
  Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S.
- Journal Title
  
  Hum Mol Genet. 18(20)
  
  Pages: 3978-86
- Data Source
  KAKENHI-PROJECT-20890062
[Journal Article] FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells2009
- Author(s)
  Yui N, Okutsu R, Sohara E, Rai T, Ohta A, Noda Y, Sasaki S, Uchida S.
- Journal Title
  
  Am J Physiol Cell Physiol. 297(6)
- Data Source
  KAKENHI-PROJECT-20890062
[Journal Article] Targeted disruption of the Wnk4 gene decreases phosphorylation of NaCl cotransporter, increases Na excretion and lowers blood pressure.2009
- Author(s)
  Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S
- Journal Title
  
  Hum Mol Genet. 18
  
  Pages: 3978-3986
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890062
[Journal Article] Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis2009
- Author(s)
  Ohta E, Itoh T, Nemoto T, Kumagai J, Ko SB, Ishibashi K, Ohno M, Uchida K, Ohta A, Sohara E, Uchida S, Sasaki S, Rai T.
- Journal Title
  
  Am J Physiol Cell Physiol. 297(6)
- Data Source
  KAKENHI-PROJECT-20890062
[Journal Article] 嚢胞性腎疾患とNek8(NIMA-related kinase 8)2009
- Author(s)
  蘇原映誠
- Journal Title
  
  腎と透析 67
  
  Pages: 790-791
- Data Source
  KAKENHI-PROJECT-20890062
[Journal Article] Pancreas specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis.2009
- Author(s)
  Ohta E, Itoh T, Nemoto T, Kumagai J, Ko SB, Ishibashi K, Ohno M, Uchida K, Ohta A, Sohara E, Uchida S, Sasaki S, Rai T.
- Journal Title
  
  Am J Physiol Cell Physiol. 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890062
[Presentation] Faulty sensing: Cellular energy sensor links to the progression of chronic kidney disease2023
- Author(s)
  Eisei Sohara
- Organizer
  JSN/ISN Joint Symposium, The 66th Annual Meeting of the Japanese Society of Nephrology
- Invited
- Data Source
  KAKENHI-PROJECT-22K19518
[Presentation] Understanding Cystic Kidney Disease by Comprehensive Genetic Panel Test2022
- Author(s)
  Eisei Sohara
- Organizer
  JSN/ASN Joint Symposium, The 66th Annual Meeting of the Japanese Society of Nephrology
- Invited
- Data Source
  KAKENHI-PROJECT-22K19518
[Presentation] 腎代謝応答の感知不全は腎臓病に直結する2021
- Author(s)
  蘇原映誠.
- Organizer
  第64回日本腎臓学会学術総会シンポジウム.
- Invited
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] ADTKD：的確な診断と最善の治療を目指して2021
- Author(s)
  蘇原映誠, 藤丸拓也, 森崇寧, 内田信一.
- Organizer
  第64回日本腎臓学会学術総会教育講演.
- Invited
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] 慢性腎臓病における塩分感受性亢進と免疫機構によるWNKシグナル制御2020
- Author(s)
  蘇原映誠
- Organizer
  日本腎臓学会学術総会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] 遺伝学の発展がもたらす遺伝性腎疾患診療の新戦略2020
- Author(s)
  蘇原映誠
- Organizer
  第99回神奈川腎研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] Primary Cilia の生理的機能と嚢胞性腎疾患2019
- Author(s)
  蘇原映誠
- Organizer
  第 62 回日本腎臓学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] Whole exome data in rare disease gene discovery2019
- Author(s)
  EISEI SOHARA
- Organizer
  International Society of Nephrology, World Congress of Nephrology 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] 腎生検にて NPHP-MCKD complex と診断された成人症例の遺伝的背景2019
- Author(s)
  藤丸拓也, 蘇原映誠, 森崇寧, 萬代新太郎, 千賀宗子, 菊地寛昭, 安藤史顕, 森雄太郎, 野村尚弘, 岡戸丈和, 頼建光, 長田道夫, 内田信一
- Organizer
  第 62 回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] 慢性腎臓病におけるエネルギー不全感知障害2019
- Author(s)
  蘇原映誠
- Organizer
  第 10 回腎不全研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] 常染色体優性腎性尿崩症症例の解析と遺伝性腎疾患患者層別化の重要性2019
- Author(s)
  蘇原映誠, 桑原道雄, 安藤史顕, 森崇寧, 頼建光, 佐々木成, 内田信一
- Organizer
  第 49 回日本腎臓学会東部学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] 次世代シークエンサーによる腎臓病網羅的遺伝子診断パネルの構築-網羅的遺伝子解析の重要性2019
- Author(s)
  森崇寧, 藤丸拓也, 蘇原映誠, 内田信一
- Organizer
  第 62 回日本腎臓学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] TNF αは腎臓での WNK1 分解を抑制して塩分感受性を亢進させる2019
- Author(s)
  古荘泰佑, 蘇原映誠, 萬代新太郎, 菊池寛昭, 高橋直宏, 藤丸拓也, 橋本博子, 新井洋平, 安藤史顕, 銭谷慕子, 森崇寧, 須佐紘一郎, 磯部清志, 野村尚弘, 岡戸丈和, 頼建光, 内田信一
- Organizer
  第 62 回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] Tubular basement membrane duplication and cell interposition are distinctive histological findings in the adult patients genetically diagnosed with NPHP-RCs2019
- Author(s)
  Takuya Fujimaru, Takayasu Mori, Michio Nagata, Shintaro Mandai, Motoko Chiga, Hiroaki Kikuchi, Fumiaki Ando, Yutaro Mori, Koichiro Susa, Kiyoshi Isobe, Soichiro Iimori, Naohiro Nomura, Shotaro Naito, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara
- Organizer
  ASN Kidney Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] Renal TNF α activates WNK phosphorylation cascade and contributes to salt-sensitive hypertension in CKD2019
- Author(s)
  Furusho T, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Mori T, Susa K, Isobe K, Nomura N, Okado T, Rai T, Yamamoto K, Uchida S, Sohara E
- Organizer
  ASN Kidney Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] 遺伝学の発展がもたらす遺伝性腎疾患診療の新戦略2019
- Author(s)
  蘇原映誠, 藤丸拓也, 森崇寧, 内田信一
- Organizer
  第 49 回日本腎臓学会西部学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] WNK signaling in salt-sensitive hypertension and electrolyte disorder2019
- Author(s)
  Eisei Sohara
- Organizer
  JSN/ASN Joint Symposium, The 62nd Annual Meeting of the Japanese Society of Nephrology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] Failure to sense energy depletion in chronic kidney disease2019
- Author(s)
  EISEI SOHARA
- Organizer
  The 9th Federation of the Asian and Oceanian Physiological Societies Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] Failure to sense energy depletion in chronic kidney disease2019
- Author(s)
  Sohara Eisei
- Organizer
  The 42nd Annual Meeting of the Molecular Biology Society of Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] 低タンパク食は AMPK の AMP/ATP 比感知障害改善を介して腎保護効果を発揮する2019
- Author(s)
  菊池寛昭, 蘇原映誠, 野村尚弘, 森崇寧, 頼建光, 内田信一
- Organizer
  第 62 回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03672
[Presentation] WNK シグナルが明らかにした塩分感受性高血圧のメカニズム.2018
- Author(s)
  蘇原映誠
- Organizer
  第 54 回高血圧関連疾患モデル学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] ゲノムから解くADPKD: 嚢胞性腎疾患の網羅的遺伝子解析システムの開発と応用2018
- Author(s)
  蘇原映誠, 森崇寧, 藤丸拓也, 内田信一.
- Organizer
  第 61 回日本腎臓学会学術総会.
- Invited
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Association between Body Mass Index and In-hospital Mortality in Emergently Hospitalized Dialysis-Independent CKD Patients; A Nationwide Retrospective Cohort Study in Japan2018
- Author(s)
  Hiroaki Kikuchi, Eiichiro Kanda, Fumiaki Ando, Hidehiko Sato, Kiyoshi Isobe, Takayasu Mori, Soichiro Iimori, Naohiro Nomura, Shotaro Naito, Eisei Sohara, Tomokazu Okado, Shinichi Uchida, Kiyohide Fushimi and Tatemitsu Rai
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Genomic Background of Adults with Suspected Ciliopathy on Renal Biopsy.2018
- Author(s)
  Fujimaru T, Mori T, Mandai S, Chiga M, Kikuchi H, Ando F, Mori Y, Susa K, Isobe K, Iimori S, Nomura N, Naito S, Okado T, Rai T, Nagatsuji K, Nagahama K, Mishima E, Mochizuki T, Sekine A, Hoshino J, Ubara Y, Uchida S, Sohara E.
- Organizer
  ASN Kidney Week 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Generation and Analysis of KLHL2 Knockout Mice.2018
- Author(s)
  Kasagi Y, Takahashi D, Aida T, Nishida H, Nomura N, Zeniya M, Mori T, Sasaki E, Ando F, Rai T, Uchida S, Sohara E.
- Organizer
  ISN Frontiers Meetings 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Genomic diagnosis of adult polycystic kidney disease with no family history2018
- Author(s)
  Takuya Fujimaru, Takayasu Mori, Akinari Sekine, Shintaro Mandai, Motoko Chiga, Hiroaki Kikuchi, Fumiaki Ando, Yutaro Mori, Naohiro Nomura, Soichiro Iimori, Shotaro Naito, Tomokazu Okado, Tatemitsu Rai, Junichi Hoshino, Yoshifumi Ubara, Shinichi Uchida, Eisei Sohara
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] Role of ClC-K and Barttin in Low-Potassium induced Sodium-Chloride Cotransporter Activation and Hypertension in Mouse Kidney2018
- Author(s)
  Naohiro Nomura, Wakana Shoda, Yuanlong Wang, Daiei Takahashi, Moko Zeniya, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] Amelioration of Renal Fibrosis and Tubulointerstitial Damage in Fat-1 Transgenic CKD Mice by Compensation of Decreased Omega-3 Fatty Acids in the Kidney.2018
- Author(s)
  Takahashi N, Kikuchi H, Ishihara T, Arita M, Furusho T, Ando F, Mori T, Isobe K, Susa K, Nomura N, Rai T, Uchida S, Sohara E
- Organizer
  ASN Kidney Week 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Decreased protein level of KLHL3 is involved in PHAII caused by CUL3 mutation.2018
- Author(s)
  Yoshida S, Araki Y, Mori T, Sasaki E, Kasagi Y, Isobe K, Susa K, Inoue Y, Rai T, Uchida S，Sohara E.
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] 多発性嚢胞腎診療の新しい展望~ゲノムから薬剤治療まで~.2018
- Author(s)
  蘇原映誠
- Organizer
  第 48 回日本腎臓学会東部学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] 家族歴のない成人多発性腎嚢胞患者における網羅的遺伝子解析を用いた遺伝子診断と臨床所見の検討2018
- Author(s)
  藤丸拓也, 森崇寧, 関根章成, 萬代新太郎, 千賀宗子, 菊池寛昭, 安藤史顕, 森雄太郎, 野村尚弘, 飯盛聡一郎, 内藤省太郎, 岡戸丈和, 頼建光, 星野純一, 乳原善文, 蘇原映誠, 内田信一
- Organizer
  第28回バゾプレシン研究会
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] WNK1-SPAK-NCC signaling cascade is involved in salt sensitive hypertension induced by aristolochic acid nephropathy.2018
- Author(s)
  Furusho T, Sohara E, Mandai S, Kikuchi H, Ando F, Zeniya M, Mori T, Nomura N, Rai T, Uchida S.
- Organizer
  ASN Kidney Week 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Metformin has natriuretic effects through reduction of the sodium-chrolide cotransporter phosphorylation.2018
- Author(s)
  Hashimoto H, Nomura N, Shoda W, Isobe K, Kikuchi H, Yamamoto K, Fujimaru T, Ando F, Mori T, Okado T, Rai T, Uchida S, Sohara E.
- Organizer
  ASN Kidney Week 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] WNK1 suppresses LPS-induced cytokine production in macrophage2018
- Author(s)
  Arai Y, Sohara E, Asano K, Tanaka M, Nomura N, Rai T, Uchida S.
- Organizer
  ISN Frontiers Meetings 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Association between Body Mass Index and In-hospital Mortality in Emergently Hospitalized Dialysis-Independent CKD Patients; A Nationwide Retrospective Cohort Study in Japan2018
- Author(s)
  Hiroaki Kikuchi, Eiichiro Kanda, Fumiaki Ando, Hidehiko Sato, Kiyoshi Isobe, Takayasu Mori, Soichiro Iimori, Naohiro Nomura, Shotaro Naito, Eisei Sohara, Tomokazu Okado, Shinichi Uchida, Kiyohide Fushimi and Tatemitsu Rai
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] 家族歴のない成人多発性腎嚢胞患者における網羅的遺伝子解析を用いた遺伝子診断と臨床所見の検討2018
- Author(s)
  藤丸拓也, 森崇寧, 関根章成, 萬代新太郎, 千賀宗子, 菊池寛昭, 安藤史顕, 森雄太郎, 野村尚弘, 飯盛聡一郎, 内藤省太郎, 岡戸丈和, 頼建光, 星野純一, 乳原善文, 蘇原映誠, 内田信一
- Organizer
  第28回バゾプレシン研究会
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Genomic diagnosis of adult polycystic kidney disease with no family history2018
- Author(s)
  Takuya Fujimaru, Takayasu Mori, Akinari Sekine, Shintaro Mandai, Motoko Chiga, Hiroaki Kikuchi, Fumiaki Ando, Yutaro Mori, Naohiro Nomura, Soichiro Iimori, Shotaro Naito, Tomokazu Okado, Tatemitsu Rai, Junichi Hoshino, Yoshifumi Ubara, Shinichi Uchida, Eisei Sohara
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Role of ClC-K and Barttin in Low-Potassium induced Sodium-Chloride Cotransporter Activation and Hypertension in Mouse Kidney2018
- Author(s)
  Naohiro Nomura, Wakana Shoda, Yuanlong Wang, Daiei Takahashi, Moko Zeniya, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] AKAPs-PKA Disruptors Robustly Increase AQP2 Activity Independently of Vasopressin.2018
- Author(s)
  Ando F, Yui N, Nomura N, Sohara E, Rai T, Sasaki S, Uchida S.
- Organizer
  ASN Kidney Week 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] 次世代シークエンサーにおける嚢胞性腎疾患遺伝子診断パネルの構築2017
- Author(s)
  藤丸拓也, 蘇原映誠, 森崇寧, 萬代新太郎, 千賀宗子, 菊池寛昭, 安藤史顕, 森雄太郎, 野村尚弘, 内藤省太郎, 岡戸丈和, _建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Generation and Analysis of KLHL2 Knockout Mice2017
- Author(s)
  Yuri Kasagi, Daiei Takahashi, Tomomi Aida, Hidenori Nishida, Naohiro Nomura, Moko Zeniya, Takayasu Mori, Emi Sasaki, Fumiaki Ando, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara
- Organizer
  The 50th Annual Meeting of the American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] 保存期慢性腎臓病患者におけるサルコペニアの危険因子の検討2017
- Author(s)
  石川聖子, 内藤省太郎, 銭谷慕子, 高橋大栄, 佐藤英彦, 飯盛聡一郎, 野村尚弘, 蘇原映誠, 神田英一郎, 岡戸丈和, 頼建光, 内田信一.
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] ループ利尿薬はマウス骨格筋細胞分化および運動による筋肥大効果を抑制する2017
- Author(s)
  萬代新太郎, 古川晋, 小高愛未, 畑裕, 森崇寧, 野村尚弘, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] Role of ClC-K and Barttin in Low-Potassium induced Sodium-Chloride Cotransporter Activation and Hypertension in Mouse Kidney2017
- Author(s)
  Naohiro Nomura, Wakana Shoda, Yuanlong Wang, Daiei Takahashi, Moko Zeniya, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
- Organizer
  The 50th Annual Meeting of the American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] WNK-SPAKシグナル系阻害薬の開発とその可能性.2017
- Author(s)
  蘇原映誠.
- Organizer
  臨床高血圧フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] 変異CUL3によるPHAIIの発症にはKLHL3の発現低下が関与する2017
- Author(s)
  吉田紗矢香, 蘇原映誠, 荒木雄也, 笠木祐里, 佐々木絵美, 須佐紘一郎, 森崇寧, 井上佑一, 磯部清志, 頼建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] 多発性嚢胞腎におけるゲノム情報と環境因子のクロストーク.2017
- Author(s)
  蘇原映誠.
- Organizer
  第27回バゾプレシン研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] Pseudohypoaldosteronism2017
- Author(s)
  Sohara Eisei
- Organizer
  10th International Meeting of Pediatric Endocrinology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] 遺伝性高血圧疾患からPrecision Medicineを考える2017
- Author(s)
  蘇原映誠.
- Organizer
  第40回日本高血圧学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] WNK1はマクロファージにおけるLPS誘導性サイトカイン産生を抑制する2017
- Author(s)
  新井洋平, 蘇原映誠, 浅野謙一, 田中正人, 頼建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] 次世代シークエンサーを用いた遺伝性腎疾患の解析2017
- Author(s)
  蘇原映誠, 森崇寧, 内田信一.
- Organizer
  第60回日本腎臓学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] 高カリウムはカリシニューリンを活性化しNa-Cl共輸送体(NCC)を脱リン酸化して尿中カリウム排泄を促進する.2017
- Author(s)
  正田若菜, 野村尚弘, 安藤史顕, 森雄太郎, 森崇寧, 蘇原映誠, 頼建光, 内田信一.
- Organizer
  第27回バゾプレシン研究会.
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] 新規腎線維化改善薬としてのbortezomibの検討2017
- Author(s)
  銭谷慕子, 森崇寧, 油井直史, 野村尚弘, 千賀宗子, 高橋大栄, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] 塩は近位尿細管細胞においてJAK/STAT系を介してIFNgamma関連ケモカインを抑制する2017
- Author(s)
  新井洋平, 蘇原映誠, 高橋大栄, 浅野謙一, 田中正人, 小田真由美、洪繁、洪実, 萬代新太郎, 野村尚弘, 頼建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] WNK-SPAKシグナル系阻害薬の開発とその可能性.2017
- Author(s)
  蘇原映誠.
- Organizer
  臨床高血圧フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] WNK kinase signalling to cation chloride transporters2017
- Author(s)
  Sohara Eisei
- Organizer
  Symposium, INTERNATIONAL UNION OF PHYSIOLOGICAL SCIENCE, 38th World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] WNK シグナルを介した新しい塩分感受性調節機構の解明2017
- Author(s)
  蘇原映誠.
- Organizer
  第40回日本高血圧学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] CIC-Kチャネルはカリウム摂取不足時のNCC活性化と血圧上昇に重要である2017
- Author(s)
  野村尚弘, 正田若菜, 高橋大栄, 銭谷慕子, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] CIC-Kチャネルはカリウム摂取不足時のNCC活性化と血圧上昇に重要である2017
- Author(s)
  野村尚弘, 正田若菜, 高橋大栄, 銭谷慕子, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] 高カリウムはカリシニューリンを活性化しNa-Cl共輸送体(NCC)を脱リン酸化して尿中カリウム排泄を促進する.2017
- Author(s)
  正田若菜, 野村尚弘, 安藤史顕, 森雄太郎, 森崇寧, 蘇原映誠, 頼建光, 内田信一.
- Organizer
  第27回バゾプレシン研究会.
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] WNK kinase signalling to cation chloride transporters2017
- Author(s)
  Sohara Eisei
- Organizer
  Symposium, INTERNATIONAL UNION OF PHYSIOLOGICAL SCIENCE, 38th World Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] 保存期慢性腎臓病患者におけるサルコペニアの危険因子の検討2017
- Author(s)
  石川聖子, 内藤省太郎, 銭谷慕子, 高橋大栄, 佐藤英彦, 飯盛聡一郎, 野村尚弘, 蘇原映誠, 神田英一郎, 岡戸丈和, 頼建光, 内田信一.
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] 次世代シークエンサーにおける嚢胞性腎疾患遺伝子診断パネルの構築2017
- Author(s)
  藤丸拓也, 蘇原映誠, 森崇寧, 萬代新太郎, 千賀宗子, 菊池寛昭, 安藤史顕, 森雄太郎, 野村尚弘, 内藤省太郎, 岡戸丈和, _建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] WNK4は脂肪細胞分化の制御因子である2017
- Author(s)
  高橋大栄, 森崇寧, 蘇原映誠. 田中都, 千賀宗子, 井上佑一, 野村尚弘, 銭谷慕子, 越智広樹, 竹田秀, 菅波孝祥, 頼建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Genomic background of adult polycystic kidney disease patients without a family history2017
- Author(s)
  Takuya Fujimaru, Takayasu Mori, Akinari Sekine, Shintaro Mandai, Motoko Chiga, Hiroaki Kikuchi , Fumiaki Ando, Yutaro Mori, Naohiro Nomura, Shotaro Naito, Tomokazu Okado, Tatemitsu Rai, Junichi Hoshino, Yoshifumi Ubara, Shinichi Uchida, Eisei Sohara
- Organizer
  The 50th Annual Meeting of the American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] KLHL2は腎臓でWNK4蛋白の分解を行う2017
- Author(s)
  笠木祐里,蘇原映誠,相田知海,高橋大栄,西田秀範,野村尚弘,銭谷慕子,森崇寧,佐々木絵美,安藤史顕,頼建光,内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Decreased protein expression of KLHL3 is involved in the pathogenesis of PHAII caused by CUL3 mutation in vivo.2017
- Author(s)
  Sayaka Yoshida, Yuya Araki, Takayasu Mori, Emi Sasaki, Yuri Kasagi, Kiyoshi Isobe, Koichiro Susa, Yuichi Inoue, Tatemitsu Rai, Shinichi Uchida，Eisei Sohara.
- Organizer
  The 51th Annual Meeting of American Society of Nephrology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Pseudohypoaldosteronism2017
- Author(s)
  Sohara Eisei
- Organizer
  10th International Meeting of Pediatric Endocrinology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] 遺伝性高血圧疾患からPrecision Medicineを考える2017
- Author(s)
  蘇原映誠.
- Organizer
  第40回日本高血圧学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] 多発性嚢胞腎におけるゲノム情報と環境因子のクロストーク.2017
- Author(s)
  蘇原映誠.
- Organizer
  第27回バゾプレシン研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] 塩は近位尿細管細胞においてJAK/STAT系を介してIFNgamma関連ケモカインを抑制する2017
- Author(s)
  新井洋平, 蘇原映誠, 高橋大栄, 浅野謙一, 田中正人, 小田真由美、洪繁、洪実, 萬代新太郎, 野村尚弘, 頼建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Association between Body Mass Index and In-hospital Mortality in Emergently Hospitalized Dialysis-Independent CKD Patients; A Nationwide Retrospective Cohort Study in Japan2017
- Author(s)
  Hiroaki Kikuchi, Eiichiro Kanda, Fumiaki Ando, Hidehiko Sato, Kiyoshi Isobe, Takayasu Mori, Soichiro Iimori, Naohiro Nomura, Shotaro Naito, Eisei Sohara, Tomokazu Okado, Shinichi Uchida, Kiyohide Fushimi and Tatemitsu Rai
- Organizer
  The 50th Annual Meeting of the American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] TTPでの血漿交換治療の施行回数と在院死亡についての検討2017
- Author(s)
  佐藤英彦, 飯盛聡一郎, 銭谷慕子, 高橋大栄, 野村尚弘, 内藤省太郎, 蘇原映誠, 岡戸丈和, 内田信一, 伏見清秀, 頼建光
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] WNK1はマクロファージにおけるLPS誘導性サイトカイン産生を抑制する2017
- Author(s)
  新井洋平, 蘇原映誠, 浅野謙一, 田中正人, 頼建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Role of ClC-K and Barttin in Low-Potassium induced Sodium-Chloride Cotransporter Activation and Hypertension in Mouse Kidney2017
- Author(s)
  Naohiro Nomura, Wakana Shoda, Yuanlong Wang, Daiei Takahashi, Moko Zeniya, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
- Organizer
  The 50th Annual Meeting of the American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] Generation and Analysis of KLHL2 Knockout Mice2017
- Author(s)
  Yuri Kasagi, Daiei Takahashi, Tomomi Aida, Hidenori Nishida, Naohiro Nomura, Moko Zeniya, Takayasu Mori, Emi Sasaki, Fumiaki Ando, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara
- Organizer
  The 50th Annual Meeting of the American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] 新規腎線維化改善薬としてのbortezomibの検討2017
- Author(s)
  銭谷慕子, 森崇寧, 油井直史, 野村尚弘, 千賀宗子, 高橋大栄, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] 次世代シークエンサーを用いた遺伝性腎疾患の解析2017
- Author(s)
  蘇原映誠, 森崇寧, 内田信一.
- Organizer
  第60回日本腎臓学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] KLHL2は腎臓でWNK4蛋白の分解を行う2017
- Author(s)
  笠木祐里,蘇原映誠,相田知海,高橋大栄,西田秀範,野村尚弘,銭谷慕子,森崇寧,佐々木絵美,安藤史顕,頼建光,内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] Association between Body Mass Index and In-hospital Mortality in Emergently Hospitalized Dialysis-Independent CKD Patients; A Nationwide Retrospective Cohort Study in Japan2017
- Author(s)
  Hiroaki Kikuchi, Eiichiro Kanda, Fumiaki Ando, Hidehiko Sato, Kiyoshi Isobe, Takayasu Mori, Soichiro Iimori, Naohiro Nomura, Shotaro Naito, Eisei Sohara, Tomokazu Okado, Shinichi Uchida, Kiyohide Fushimi and Tatemitsu Rai
- Organizer
  The 50th Annual Meeting of the American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] ループ利尿薬はマウス骨格筋細胞分化および運動による筋肥大効果を抑制する2017
- Author(s)
  萬代新太郎, 古川晋, 小高愛未, 畑裕, 森崇寧, 野村尚弘, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] TTPでの血漿交換治療の施行回数と在院死亡についての検討2017
- Author(s)
  佐藤英彦, 飯盛聡一郎, 銭谷慕子, 高橋大栄, 野村尚弘, 内藤省太郎, 蘇原映誠, 岡戸丈和, 内田信一, 伏見清秀, 頼建光
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] WNK4は脂肪細胞分化の制御因子である2017
- Author(s)
  高橋大栄, 森崇寧, 蘇原映誠. 田中都, 千賀宗子, 井上佑一, 野村尚弘, 銭谷慕子, 越智広樹, 竹田秀, 菅波孝祥, 頼建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] Genomic background of adult polycystic kidney disease patients without a family history2017
- Author(s)
  Takuya Fujimaru, Takayasu Mori, Akinari Sekine, Shintaro Mandai, Motoko Chiga, Hiroaki Kikuchi , Fumiaki Ando, Yutaro Mori, Naohiro Nomura, Shotaro Naito, Tomokazu Okado, Tatemitsu Rai, Junichi Hoshino, Yoshifumi Ubara, Shinichi Uchida, Eisei Sohara
- Organizer
  The 50th Annual Meeting of the American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] 変異CUL3によるPHAIIの発症にはKLHL3の発現低下が関与する2017
- Author(s)
  吉田紗矢香, 蘇原映誠, 荒木雄也, 笠木祐里, 佐々木絵美, 須佐紘一郎, 森崇寧, 井上佑一, 磯部清志, 頼建光, 内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] WNK シグナルを介した新しい塩分感受性調節機構の解明2017
- Author(s)
  蘇原映誠.
- Organizer
  第40回日本高血圧学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] Decreased protein expression of KLHL3 is involved in the pathogenesis of PHAII caused by CUL3 mutation in vivo.2017
- Author(s)
  Sayaka Yoshida, Yuya Araki, Takayasu Mori, Emi Sasaki, Yuri Kasagi, Kiyoshi Isobe, Koichiro Susa, Yuichi Inoue, Tatemitsu Rai, Shinichi Uchida，Eisei Sohara.
- Organizer
  The 51th Annual Meeting of American Society of Nephrology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] 腎性尿崩症治療を目指したAQP2 細胞内局在制御機構の解明2016
- Author(s)
  蘇原映誠
- Organizer
  第43回日本神経内分泌学会学術集会
- Place of Presentation
  アクトシティ浜松コングレスセンター（静岡県、浜松市）
- Invited
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] The proteasome inhibitor bortezomib attenuates renal fibrosis in mice.2016
- Author(s)
  Zeniya M, Mori T, Yui N, Nomura N, Chiga M, Sohara E, Rai T, Uchida S.
- Organizer
  The 49th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Chicago（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Targeted Metabolomic Analysis of Kidney from the Subtotal Nephrectomy Mouse Model of Chronic Kidney Disease.2016
- Author(s)
  Kikuchi H, Nomura N, Minamishima Y, Rai T, Uchida S, Sohara E.
- Organizer
  The 49th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Chicago（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] 次世代シークエンサーを用いた遺伝性腎疾患の解析2016
- Author(s)
  蘇原映誠, 森崇寧, 内田信一
- Organizer
  第４６回日本腎臓学会東部学術大会
- Place of Presentation
  京王プラザホテル（東京都、新宿区）
- Invited
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Calcineurin Rapidly Dephosphorylates Sodium-ChlorideCotransporter in Response to High Potassium Intake.2016
- Author(s)
  Shoda W, Nomura N, Ando F, Mori Y, Mori T, Sohara E, Rai T, Uchida S.
- Organizer
  The 49th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Chicago（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Generation of p62/SQSTM1 (p62) KO Cell Lines Using CRISPR/Cas9 -The Role of p62 on WNK1 Regulation by Changes of Extracellular Potassium Concentration2016
- Author(s)
  Mori Y, Mandai S, Mori T, Sohara E, Rai T, Uchida S.
- Organizer
  The 49th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Chicago（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Development of a Customized Diagnostic Panel for Targeted Exome Sequencing of Polycystic Kidney Diseases.2016
- Author(s)
  Fujimaru T, Mori T, Mandai S, Chiga M, Kikuchi H, Ando F, Mori Y, Nomura N, Naito S, Okado T, Rai T, Uchida S, Sohara E.
- Organizer
  The 49th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Chicago（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] WNK4 regulates adipocyte differentiation in 3T3-L1 cells.2016
- Author(s)
  Takahashi D, Mori T, Sohara E, Chiga M, Inoue Y, Nomura N, Zeniya M, Rai T, Uchida S.
- Organizer
  The 49th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Chicago（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Targeted Metabolomic Analysis of Kidney from the Subtotal Nephrectomy Mouse Model of Chronic Kidney Disease.2016
- Author(s)
  Kikuchi H, Nomura N, Minamishima Y, Rai T, Uchida S, Sohara E.
- Organizer
  The 49th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Chicago（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Drug Repositioning Screening for Keap1-Nrf2 Binding Inhibitors Using Fluorescent Correlation Spectroscopy.2016
- Author(s)
  Yoshizaki Y, Sohara E, Mori T, Kikuchi E, Takahashi D, Zeniya M, Araki Y, Mori Y, Ando F, Rai T, Uchida S.
- Organizer
  The 49th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Chicago（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Generation and Analysis of KLHL3 Knockout Mice.2016
- Author(s)
  Sasaki E, Susa K, Mori T, Isobe K, Araki Y, Inoue Y, Rai T, Uchida S, Sohara E.
- Organizer
  The 49th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Chicago（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] 次世代シークエンサーを用いた遺伝性腎疾患の解析.2016
- Author(s)
  蘇原映誠, 森崇寧, 内田信一
- Organizer
  第４６回日本腎臓学会東部学術大会
- Place of Presentation
  京王プラザホテル京王プラザホテル（東京都、新宿区）
- Invited
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] 次世代シークエンサー時代の高血圧研究の実際2016
- Author(s)
  蘇原映誠
- Organizer
  第３９回日本高血圧学会総会
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Generation and Analysis of KLHL3 Knockout Mice.2016
- Author(s)
  Sasaki E, Susa K, Mori T, Isobe K, Araki Y, Inoue Y, Rai T, Uchida S, Sohara E.
- Organizer
  The 49th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Chicago（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] 次世代シークエンサー時代の高血圧研究の実際2016
- Author(s)
  蘇原映誠
- Organizer
  第３９回日本高血圧学会総会
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-16K15467
[Presentation] Development of a Customized Diagnostic Panel for Targeted Exome Sequencing of Polycystic Kidney Diseases.2016
- Author(s)
  Fujimaru T, Mori T, Mandai S, Chiga M, Kikuchi H, Ando F, Mori Y, Nomura N, Naito S, Okado T, Rai T, Uchida S, Sohara E.
- Organizer
  The 49th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Chicago（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] 腎性尿崩症治療を目指したAQP2 細胞内局在制御機構の解明.2016
- Author(s)
  蘇原映誠
- Organizer
  第43回日本神経内分泌学会学術集会
- Place of Presentation
  アクトシティ浜松コングレスセンター（静岡県、浜松市）
- Invited
- Data Source
  KAKENHI-PROJECT-16H05314
[Presentation] Cullin3 変異を持つ偽性低アルドステロン症 II 型(PHAII)モデルマウスの作製.2015
- Author(s)
  荒木雄也, 井上佑一, 森崇寧, 磯部清志, 菊池絵梨子, 佐々木成, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第 58 回日本腎臓学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県,名古屋)
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] Combination of Low Body Mass Index and Serum Albumin Level Leads to Chronic Kidney Disease Progression: The Chronic Kidney Disease–Research of Outcomes in Treatment and Epidemiology Study.2015
- Author(s)
  Kikuchi H, Kanda E, Iimori S, Naito S, Sasaki S, Sohara E, Okado T, Rai T, Uchida S.
- Organizer
  The 48th Annual Meeting of American Society of Nephrology
- Place of Presentation
  San Diego(USA)
- Year and Date
  2015-11-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] Angiotensin II による血管平滑筋収縮における, KLHL2-WNK3-SPAK-NKCC1 カスケードの関与.2015
- Author(s)
  銭谷慕子, 高橋大栄, 森雄太郎, 森崇寧, 蘇原映誠, 頼建光, 内田信一.
- Organizer
  第 6 回分子腎臓フォーラム.
- Place of Presentation
  グランフロント大阪(大阪府,大阪市)
- Year and Date
  2015-09-05
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] Generation of Hypertension-Associated STK39 Polymorphism Knock-in Cell Lines with the CRISPR/Cas9 System.2015
- Author(s)
  Mandai S, Mori T, Sohara E, Rai T, Uchida S.
- Organizer
  The 48th Annual Meeting of American Society of Nephrology
- Place of Presentation
  San Diego(USA)
- Year and Date
  2015-11-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] The Major Contribution of WNK4 to the Pathogenesis of Pseudohypoaldosteronism Type II (PHAII) Caused by the KLHL3 Mutation R528H.2015
- Author(s)
  Susa K, Sohara E, Takahashi D, Rai T, Uchida S.
- Organizer
  The 48th Annual Meeting of American Society of Nephrology
- Place of Presentation
  San Diego(USA)
- Year and Date
  2015-11-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] WNK キナーゼ分解を介した新たな塩分感受性制御機構.2015
- Author(s)
  蘇原映誠
- Organizer
  第 40 回関東腎研究会
- Place of Presentation
  クラブ関東(東京都、東京)
- Year and Date
  2015-07-25
- Invited
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] PKAとAktによるKLHL3リン酸化がWNK4との結合を制御する.2015
- Author(s)
  吉崎幸, 蘇原映誠, 森崇寧, 若林麻衣, 高橋大栄, 銭谷慕子, 菊池絵梨子, 森雄太郎, 荒木雄也, 安藤史顕, 頼建光, 佐々木成, 内田信一
- Organizer
  第 58 回日本腎臓学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県,名古屋)
- Year and Date
  2015-09-05
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] 遺伝性腎疾患が明らかにする腎生理と新たな創薬への道.2015
- Author(s)
  蘇原映誠, 森崇寧, 頼建光, 内田信一.
- Organizer
  第 58 回日本腎臓学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県,名古屋)
- Year and Date
  2015-09-05
- Invited
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] Potassium-induced dephosphorylation of renal sodium-chloride cotransporter is NOT dependent on the anions.2015
- Author(s)
  Nomura N, Shoda W, Sohara E, Rai T, Uchida S.
- Organizer
  The 48th Annual Meeting of American Society of Nephrology
- Place of Presentation
  San Diego(USA)
- Year and Date
  2015-11-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] 次世代シークエンサーを用いた遺伝性腎疾患網羅的診断キットの開発.2015
- Author(s)
  森崇寧, 細道一善, 蘇原映誠, 頼建光, 佐々木成, 井ノ上逸朗, 内田信一.
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県,名古屋)
- Year and Date
  2015-09-05
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] p62/SQSTM1 が関わる WNK4 の選択的オートファジーと偽性低アルドステロン症 II 型との関わり2015
- Author(s)
  森雄太郎, 森崇寧, 若林麻衣, 銭谷慕子, 蘇原映誠, 頼建光, 佐々木成, 内田信一
- Organizer
  第 58 回日本腎臓学会学術総会.
- Place of Presentation
  名古屋国際会議場(愛知県,名古屋)
- Year and Date
  2015-09-05
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] Generation and analysis of knock-in mice carrying pseudohypoaldosteronism type II-causing mutations in the cullin 3 gene.2015
- Author(s)
  Araki Y, Rai T, Sohara E, Mori T, Inoue Y, Kikuchi E, Uchida S.
- Organizer
  The 48th Annual Meeting of American Society of Nephrology
- Place of Presentation
  San Diego(USA)
- Year and Date
  2015-11-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] WNK3 Regulates Blood Pressure Through the Regulation of Vascular OSR1/SPAK-NKCC1 Phosphorylation Cascade2013
- Author(s)
  Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, Oi K, Chiga M, Takahashi D, Yang SS, Lin SH, Rai T, Sasaki S, Uchida S
- Organizer
  The 46th Annual Meeting of American Societyof Nephrology
- Place of Presentation
  Atlanta
- Year and Date
  2013-11-09
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] WNK3 Regulates Blood Pressure Through the Regulation of Vascular OSR1/SPAK-NKCC1 Phosphorylation Cascade.2013
- Author(s)
  Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, Oi K, Chiga M, Takahashi D, Yang SS, Lin SH, Rai T, Sasaki S, Uchida S.
- Organizer
  The 46th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Atlanta、アメリカ合衆国
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] WNKキナーゼによる血圧調節機構2013
- Author(s)
  蘇原映誠
- Organizer
  第42回新潟腎カンファランス
- Place of Presentation
  新潟
- Year and Date
  2013-02-21
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] Low salt intake decreased transcription and protein level of KLHL3 in mouse kidney.2013
- Author(s)
  Susa K, Sohara E, Zeniya M, Rai T, Sasaki S, Uchida S.
- Organizer
  The 46th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Atlanta、アメリカ合衆国
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] Investigation of Pathophysiology of RenalSodium and Water Transport Disorders2013
- Author(s)
  蘇原映誠
- Organizer
  日本腎臓学会平成25年度大島賞受賞講演
- Place of Presentation
  東京
- Year and Date
  2013-05-10
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] Aberrant Glycosylation and Localization of Polycystin-1 Cause Polycystic Kidney in AQP11-Knockout Mice2013
- Author(s)
  Inoue Y, Sohara E, Kobayashi K, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S
- Organizer
  Renal Week 2013, American Society ofNephrology
- Place of Presentation
  Atlanta
- Year and Date
  2013-11-07
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] Investigation of Pathophysiology of Renal Sodium and Water Transport Disorders2013
- Author(s)
  蘇原映誠
- Organizer
  日本腎臓学会平成25年度大島賞受賞講演
- Place of Presentation
  東京国際フォーラム、千代田区、東京、日本
- Invited
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] Low salt intake decreased transcription and protein level of KLHL3 in mouse kidney2013
- Author(s)
  Susa K, Sohara E, Zeniya M, Rai T, Sasaki S, Uchida S
- Organizer
  The 46th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Atlanta
- Year and Date
  2013-11-08
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] Aberrant Glycosylation and Localization of Polycystin-1 Cause Polycystic Kidney in AQP11-Knockout Mice2013
- Author(s)
  Inoue Y, Sohara E, Kobayashi K, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S.
- Organizer
  The 46th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Atlanta、アメリカ合衆国
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] Impaired trafficking of polycystin-1 may be a key mechanism of cyst formation in the aquaporin-11 knockout mouse2012
- Author(s)
  Inoue Y, Sohara E, Kobayashi K, Rai T, Ishibashi K, Sasaki S, Shinichi U
- Organizer
  The 45st Annual Meeting of American Society ofNephrology
- Place of Presentation
  San Diego
- Year and Date
  2012-11-02
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination.2012
- Author(s)
  Hossain Khan MZ, Sohara E, Ohta A, Chiga M, Inoue Y, Isobe K, Wakabayashi M, Naito S, Oi K, Rai T, Sasaki S, Uchida S.
- Organizer
  The 45th Annual Meeting of the American Society of Nephrology
- Place of Presentation
  San Diego,USA
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] WNKキナーゼによる塩分調節機構2012
- Author(s)
  蘇原映誠
- Organizer
  第34回腎臓セミナー
- Year and Date
  2012-08-25
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] Development of sandwich enzyme linked immunosorbent assay (ELISA) for measurement of urinary total and phosphorylated Na-Clcotransporter (NCC) protein2012
- Author(s)
  Isobe K, Sohara E, Rai T, Sasaki S, Uchida S
- Organizer
  The 45th Annual meeting of American Society of Nephrology
- Place of Presentation
  San Diego
- Year and Date
  2012-11-02
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] Chemical Library Screening for Direct SPAK Inhibitors by a Newly Developed ELISA System.2012
- Author(s)
  Kikuchi E, Mori T, Isobe K, Sohara E, Rai T, Sasaki S, Uchida S.
- Organizer
  The 45th Annual meeting of American Society of Nephrology
- Place of Presentation
  San Diego,USA
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] WNK4-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone.2012
- Author(s)
  Susa K, Sohara E, Isobe K, Chiga M, Rai T, Sasaki S, Uchida S..
- Organizer
  The 45th Annual Meeting of American Society of Nephrology
- Place of Presentation
  San Diego,USA
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] Development of sandwich enzyme linked immunosorbent assay (ELISA) for measurement of urinary total and phosphorylated Na-Clcotransporter (NCC) protein.2012
- Author(s)
  Isobe K, Sohara E, Rai T, Sasaki S, Uchida S.
- Organizer
  The 45th Annual meeting of American Society of Nephrology
- Place of Presentation
  San Diego,USA
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] Dietary salt intake and angiotensin II regulates WNK-SPAK-NKCC1 phosphorylation cascade in mouse aorta2012
- Author(s)
  Zeniya M, Sohara E, Oi K, Chiga M, Susa K, Mori T, Rai T,Sasaki S, Uchida S
- Organizer
  The 45th Annual Meeting of American Society of Nephrology
- Place of Presentation
  San Diego
- Year and Date
  2012-11-02
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] Dietary salt intake and angiotensin II regulates WNK-SPAK-NKCC1 phosphorylation cascade in mouse aorta.2012
- Author(s)
  Zeniya M, Sohara E, Oi K, Chiga M, Susa K, Mori T, Rai T,Sasaki S, Uchida S.
- Organizer
  The 45th Annual Meeting of American Society of Nephrology
- Place of Presentation
  San Diego,USA
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] Impaired trafficking of polycystin-1 may be a key mechanism of cyst formation in the aquaporin-11 knockout mouse.2012
- Author(s)
  Inoue Y, Sohara E, Kobayashi K, Rai T, Ishibashi K, Sasaki S, Uchida S.
- Organizer
  The 45th Annual Meeting of American Society of Nephrology
- Place of Presentation
  San Diego,USA
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination2012
- Author(s)
  Hossain Khan MZ, Sohara E, Ohta A, Chiga M, Inoue Y, Isobe K, Wakabayashi M, Naito S, Oi K, Rai T, Sasaki S, Uchida S
- Organizer
  The 45th Annual Meeting of the American Society of Nephrology
- Place of Presentation
  SanDiego, California
- Year and Date
  2012-11-02
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] WNK4-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone2012
- Author(s)
  Susa K, Sohara E, Isobe K, Chiga M, Rai T, Sasaki S, Uchida S
- Organizer
  The 45th Annual Meeting of American Society of Nephrology
- Place of Presentation
  San Diego
- Year and Date
  2012-11-02
- Data Source
  KAKENHI-PROJECT-24790836
[Presentation] WNKキナーゼ遺伝子改変マウスによるNa-Cl共輸送体制御機構の解明2011
- Author(s)
  蘇原映誠
- Organizer
  第54回日本腎臓学会学術総会ワークショップ
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22790783
[Presentation] Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney2011
- Author(s)
  Sohara E, Rai T, Yang SS, Ohta A, ChigaM, Nomura N, Lin SH, Vandewalle A, SasakiS, Uchida S.
- Organizer
  The 44th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Philadelphia
- Data Source
  KAKENHI-PROJECT-22790783
[Presentation] mpkDCT細胞とマウス腎臓におけるインスリン急性負荷によるNCCリン酸化の亢進2011
- Author(s)
  蘇原映誠、楊松昇、太田哲人、林石化、頼建光、内田信一、佐々木成
- Organizer
  第54回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22790783
[Presentation] インスリンと塩分感受性高血圧症をつなぐ新規インスリン-WNK4-NCCリン酸化カスケードの発見2010
- Author(s)
  蘇原映誠
- Organizer
  第53回日本腎臓学会学術総会ワークショップ
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22790783
[Presentation] Novel insulin-WNK4-NCC phosphorylation cascade is involved in pathogenesis of PHA II caused by WNK4 R1185C mutation.2009
- Author(s)
  蘇原映誠, Rai T, 太田哲人, 太田英里子, 佐々木成, 内田信一
- Organizer
  The 42nd Annual Meeting of American Society of Nephrology
- Place of Presentation
  San Diego, USA
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-20890062
[Presentation] Investigation of the localization of mouse WNK3 in kidney2009
- Author(s)
  Oi K, 蘇原映誠, 太田哲人, 太田英里子, 頼建光, 佐々木成, 内田信一
- Organizer
  The 42nd Annual Meeting of American Society of Nephrology
- Place of Presentation
  San Diego, USA
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-20890062
[Presentation] Novel insulin-WNK4-NCC phosphorylation cascade is involved in pathogenesis of PHA II caused by WNK4 R1185C mutation2009
- Author(s)
  Sohara E, Rai T, Ohta A, Ohta E, Sasaki S, Uchida S.
- Organizer
  The 42nd Annual Meeting of American Society of Nephrology
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-20890062
[Presentation] 新規 Insulin-WNK4-NCCリン酸化カスケードの発見と偽性低アルドステロン症II型における破綻2009
- Author(s)
  蘇原映誠, 太田哲人, 太田英里子, 頼建光, 内田信一, 佐々木成
- Organizer
  第15回分子腎臓研究会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20890062
[Presentation] 新規Insuhn-WNK4-NCCリン酸化カスケードの発見と偽性低アルドステロン症II型における破綻2009
- Author(s)
  蘇原映誠、太田哲人、太田英里子、頼建光、内田信一、佐々木成
- Organizer
  第15回分子腎臓研究会
- Place of Presentation
  京都
- Year and Date
  2009-09-05
- Data Source
  KAKENHI-PROJECT-20890062
[Presentation] Nek8(NIMA-related kinase 8)と嚢胞性腎疾患2008
- Author(s)
  蘇原映誠
- Organizer
  生理研研究会
- Place of Presentation
  愛知
- Year and Date
  2008-07-17
- Data Source
  KAKENHI-PROJECT-20890062
[Presentation] Generation of liver specific Pkd1 knockout mice2008
- Author(s)
  Eisei Sohara, Funda Saglam, Jingjing Zhang, Leah Contrino, Alexander Beck, Jing Zhou
- Organizer
  The 41st Annual meeting of American Society of Nephrology 7th
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-20890062
[Presentation] Nek8 (NIMA-related kinase 8) と嚢胞性腎疾患2008
- Author(s)
  蘇原映誠
- Organizer
  第94回東京腎生理集団会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20890062
[Presentation] Nek8 (NIMA-related kinase 8) と嚢胞性腎疾患2008
- Author(s)
  蘇原映誠
- Organizer
  生理研研究会
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-20890062
[Presentation] Generation of liver specific Pkdl knockout mice.2008
- Author(s)
  Eisei Sohara, Funda Saglam, Jingjing Zhang, Leah Contrino, Alexander Beck, Jing Zhou
- Organizer
  Annual meeting of American Society of Nephrology
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2008-11-07
- Data Source
  KAKENHI-PROJECT-20890062
[Presentation] Nek8(NIMA-related kinase 8)と嚢胞性腎疾患2008
- Author(s)
  蘇原映誠
- Organizer
  第94回東京腎生理集団会
- Place of Presentation
  東京
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-20890062
[Presentation] p62が関わる選択的オートファジーがKLHL3依存性のWNK4分解機構に関与している.
- Author(s)
  森雄太郎, 若林麻衣, 蘇原映誠, 頼建光, 内田信一, 佐々木成
- Organizer
  第57回日本腎臓学会学術総会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2014-07-04 – 2014-07-06
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] p62-mediated selective autophagy is involved in KLHL3-dependent WNK4 degradation.
- Author(s)
  Mori Y, Wakabayashi M, Mori T, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S.
- Organizer
  The 47th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2014-11-14 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in AQP11-knockout mice
- Author(s)
  Inoue Y, Sohara E, Kobayashi K, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S.
- Organizer
  The 14th Asian Pacific Congress of Nephrology.
- Place of Presentation
  Tokyo、品川プリンスホテル
- Year and Date
  2014-05-14 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] Phosphorylation of KLHL3 in the kelch-repeat regulates its binding ability to WNK4.
- Author(s)
  Yoshizaki Y, Sohara E, Mori T, Mori Y, Araki Y, Wakabayashi M, Rai T, Sasaki S, Uchida S.
- Organizer
  The 47th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2014-11-14 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] WNK4は腎NCCの正の制御因子である
- Author(s)
  高橋大栄, 森崇寧, 野村尚弘, Muhammad Zakir Hossain Khan, 荒木雄也, 銭谷慕子, 蘇原映誠, 頼建光, 佐々木成, 内田信一.
- Organizer
  第57回日本腎臓学会学術総会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2014-07-04 – 2014-07-06
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] Vitamin D Analogs Reduce the Progression of Chronic Kidney Disease: Chronic Kidney Disease Research of Outcomes in Treatment and Epidemiology Study (CKD-ROUTE Study).
- Author(s)
  Arai Y, Kanda E, Ando R, Iimori S, Sasaki S, Sohara E, Okado T, Rai T, Uchida S.
- Organizer
  The 47th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2014-11-14 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] 偽性低アルドステロン血症2型が明らかにしたWNKシグナルとその制御.
- Author(s)
  蘇原映誠, 頼建光, 内田信一, 佐々木成.
- Organizer
  第57回日本腎臓学会学術総会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2014-07-04 – 2014-07-06
- Invited
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] KLHL2 mediates angiotensin II-WNK3 singaling involved in the regulation of vascular tonus
- Author(s)
  Zeniya M, Morimoto N, Takahashi D, Mori Y, Mori T, Ando F, Araki Y, Yoshizaki Y, Inoue Y, Ishobe K, Nomura N, Oi K, Nishida H, Sasaki S, Sohara E, Rai T, Uchida S.
- Organizer
  The 47th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2014-11-14 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] 新たな体液評価の指標としての尿中エキソソーム.
- Author(s)
  頼建光, 磯部清志, 蘇原映誠, 内田信一, 佐々木成
- Organizer
  第44回日本腎臓学会東部学術大会
- Place of Presentation
  東京、ベルサール新宿グランド
- Year and Date
  2014-10-24 – 2014-10-25
- Invited
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] 遺伝性腎疾患が明らかにする腎生理と新たな創薬への道
- Author(s)
  蘇原　映誠、森　崇寧、頼　建光、内田　信一
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋、名古屋国際会議場
- Year and Date
  2015-06-05 – 2015-06-07
- Invited
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] マウス血管平滑筋においてangiotensin II刺激はKLHL2を介してWNK3-SPAK-NKCC1リン酸化カスケードを制御する.
- Author(s)
  銭谷慕子, 森本靖久, 高橋大栄, 森雄太郎, 森崇寧, 佐々木成, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第57回日本腎臓学会学術総会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2014-07-04 – 2014-07-06
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] Molecular Pathogenesis of PHAII in KLHL3R528H/+ Knock-In Mice.
- Author(s)
  Susa K, Sohara E, Rai T, Zeniya M, Mori Y, Mori T, Chiga M, Takahashi D, Isobe K, Inoue Y, Takeda N, Sasaki S, Uchida S.
- Organizer
  The 47th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2014-11-14 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] KLHL3変異マウスはWNK1及びWNK4の分解低下により偽性低アルドステロン血症II型を発症する.
- Author(s)
  須佐紘一郎, 蘇原映誠, 頼建光, 銭谷慕子, 森雄太郎, 竹田直樹, 佐々木成, 内田信一
- Organizer
  第57回日本腎臓学会学術総会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2014-07-04 – 2014-07-06
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] Higher serum phosphorus levels at the initial visit predict more rapid decline in kidney function in pre-dialysis CKD patients in Japan
- Author(s)
  Kawasaki T, Ando R, Maeda Y, Arai Y, Sato H, Iimori S, Sohara E, Okado T, Rai T, Uchida S, Sasaki S.
- Organizer
  51st ERA-EDTA Congress.
- Place of Presentation
  Amsterdam、オランダ
- Year and Date
  2014-06-01 – 2014-06-03
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] Comprehensive diagnosis of hereditary kidney diseases by a customized diagnostic panel of targeted exome sequencing
- Author(s)
  Mori T, Hosomichi K, Sohara E, Rai T, Sasaki S, Inoue I, Uchida S.
- Organizer
  The 47th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2014-11-14 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] Elongated ciliary length of proximal tubules in a PKD model AQP11 knockout mouse.
- Author(s)
  Inoue Y, Sohara E, Kobayashi K, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S.
- Organizer
  The 47th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2014-11-14 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26670428
[Presentation] Impaired degradation of WNK1 and WNK4 kinases causes PHAII in Mutant KLHL3 knock-in mice.
- Author(s)
  Sohara E, Susa K, Rai T, Zeniya M, Mori Y, Sasaki S, Uchida S
- Organizer
  The 14th Asian Pacific Congress of Nephrology
- Place of Presentation
  Tokyo、品川プリンスホテル
- Year and Date
  2014-05-14 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-26670428

1. HOSOMICHI Kazuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 頼建光

# of Collaborated Projects: 0 results

# of Collaborated Products: 14 results
3. 内田信一

# of Collaborated Projects: 0 results

# of Collaborated Products: 19 results
4. 銭谷慕子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 佐々木成

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
6. 森崇寧

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
7. 川西邦夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 佐藤杏奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 有田誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 須佐紘一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 藤丸拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. 喜多紗斗美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 藤井晋也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 影近弘之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 越智広樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 安藤史顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 石橋賢一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 田頭秀章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

sohara eisei 蘇原 映誠

SOHARA Eisei 蘇原 映誠

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Co-Researchers

エネルギー感知機構の破綻による慢性腎臓病の線維化進行機序解明と治療法開発Principal Investigator

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腎オルガノイドを用いたForward Geneticによる腎線維化制御機構の探索Principal Investigator

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Elucidation of molecular pathogenesis and development of novel therapeutic strategy of energy-sensing failure of AMPK in chronic kidney diseasePrincipal Investigator

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Elucidation of regulatory mechanism of WNK signal by protein degradation systemPrincipal Investigator

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Novel medical approach of polycystic kidney disease by the next generation sequencerPrincipal Investigator

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Development of order-made treatment of hypertension by measurement of urinary transportersPrincipal Investigator

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WNK kinase links insulin with salt-sensitive hypertensionPrincipal Investigator

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WNK kinase links salt-sensitive hypertension with obesityPrincipal Investigator

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Relationship between WNK kinase and hypertension in polycystic kidney diseasePrincipal Investigator

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[Book] 偽性低アルドステロン症II型2011

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[Book] Handb Exp Pharmacol.2009

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[Journal Article] NCC regulation by WNK signal cascade2023

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[Journal Article] Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression2023

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[Journal Article] Different Clinical Courses of Nephronophthisis in Dizygotic Twins2023

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sohara eisei 蘇原映誠

SOHARA Eisei 蘇原映誠