HARA Takahiro 原崇裕

Researcher Number	90512301
Other IDs	https://orcid.org/0000-0002-3845-8434
Affiliation (based on the past Project Information) *help	2023: 京都大学, 医生物学研究所, 助教 2016 – 2021: 京都大学, ウイルス・再生医科学研究所, 助教 2009 – 2015: 京都大学, ウイルス研究所, 助教
Review Section/Research Field	Principal Investigator Immunology / Basic Section 42030:Animal life science-related / Basic Section 49070:Immunology-related Except Principal Investigator Immunology
Keywords	Principal Investigator ストローマ細胞 / 骨髄 / IL-7 / 微小環境 / ILC / 骨髄微小環境 / 免疫微小環境 / B細胞 / Ｂ細胞 / T細胞 / 内皮細胞 / サイトカイン … More Except Principal Investigator … More ストローマ細胞 / サイトカイン / 免疫組織 / IL-15 / 微小環境 / 免疫細胞 / T細胞 / GFP / 胸腺上皮細胞 / NKT細胞 / 胸腺 / 遺伝子改変マウス / リンパ組織 / インターロイキン7 / γδ T細胞 / 小腸上皮内リンパ球 / IL-7 Less

骨微小環境による自然免疫ダイナミクスの制御機構Principal Investigator
- Principal Investigator
  
  原崇裕
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Kyoto University
Identification of the bone microenvironment that constructs the innate immune systemPrincipal Investigator
- Principal Investigator
  
  Hara Takahiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
Analysis of immune microenvironment essential for ILC2 developmentPrincipal Investigator
- Principal Investigator
  
  Hara Takahiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
Analysis of IL-7 niche in bone marrowPrincipal Investigator
- Principal Investigator
  
  Hara Takahiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
Distribution and function of IL-15-producing cells in vivo
- Principal Investigator
  
  IKUTA Koichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
Endothalial cell-derived IL-7 controls B cell development and peripheral T cell maintenancePrincipal Investigator
- Principal Investigator
  
  HARA Takahiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
Distribution and function of IL-7-producing cells
- Principal Investigator
  
  IKUTA Koichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

[Book] 感染・炎症・免疫　第４３巻2014
- Author(s)
  生田宏一、原崇裕、谷一靖江
- Total Pages
  3
- Publisher
  鳥居薬品株式会社
- Data Source
  KAKENHI-PROJECT-24790468
[Book] 医学のあゆみ　Vol.2462013
- Author(s)
  原崇裕、生田宏一
- Total Pages
  2
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-24790468
[Journal Article] The roles of IL-7 and IL-15 in niches for lymphocyte progenitors and immune cells in lymphoid organs2021
- Author(s)
  Ikuta K, Hara T, Abe S, Asahi T, Takami D, Cui G
- Journal Title
  
  Curr. Top. Microbiol. Immunol.
  
  Volume: 434 Pages: 83-101
- DOI
  10.1007/978-3-030-86016-5_4
- ISBN
  9783030860158, 9783030860165
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07604, KAKENHI-PROJECT-20K21525, KAKENHI-PROJECT-20H03501, KAKENHI-PROJECT-21J15058
[Journal Article] IL-7R-Dependent Phosphatidylinositol 3-Kinase Competes with the STAT5 Signal to Modulate T Cell Development and Homeostasis.2020
- Author(s)
  Cui G, Shimba A, Ma G, Takahara K, Tani-Ichi S, Zhu Y, Asahi T, Abe A, Miyachi H, Kitano S, Hara T, Yasunaga JI, Suwanai H, Yamada H, Matsuoka M, Ueki K, Yoshikai Y, Ikuta K.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 204 Issue: 4 Pages: 844-857
- DOI
  10.4049/jimmunol.1900456
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07604, KAKENHI-PROJECT-19K16687, KAKENHI-PROJECT-15H05789, KAKENHI-PROJECT-17K07166, KAKENHI-PLANNED-16H06496
[Journal Article] Innate-like CD27+CD45RBhigh γδ T Cells Require TCR Signaling for Homeostasis in Peripheral Lymphoid Organs.2020
- Author(s)
  Tani-Ichi S, Wagatsuma K, Hara T, Cui G, Abe S, Miyachi H, Kitano S, Ikuta K.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 204(10) Issue: 10 Pages: 2671-2684
- DOI
  10.4049/jimmunol.1801243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07604
[Journal Article] Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene.2019
- Author(s)
  Mukohira H, Hara T, Abe S, Tani-Ichi S, Sehara-Fujisawa A, Nagasawa T, Tobe K, Ikuta K.
- Journal Title
  
  International Immunology
  
  Volume: 31 Issue: 11 Pages: 729-742
- DOI
  10.1093/intimm/dxz042
- NAID
  120006872738
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07604, KAKENHI-PROJECT-18H03998
[Journal Article] Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intra-epithelial lymphocytes in the intestine2019
- Author(s)
  Zhu Yuanbo、Cui Guangwei、Miyauchi Eiji、Nakanishi Yuki、Mukohira Hisa、Shimba Akihiro、Abe Shinya、Tani-ichi Shizue、Hara Takahiro、Nakase Hiroshi、Chiba Tsutomu、Sehara-Fujisawa Atsuko、Seno Hiroshi、Ohno Hiroshi、Ikuta Koichi
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 5 Pages: 307-319
- DOI
  10.1093/intimm/dxz082
- NAID
  120006846480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05907, KAKENHI-PROJECT-19K07604, KAKENHI-PROJECT-19K16687, KAKENHI-PROJECT-19K16712, KAKENHI-PROJECT-20K16280, KAKENHI-PROJECT-20H03501, KAKENHI-PROJECT-18K07958
[Journal Article] Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR42018
- Author(s)
  Shimba A, Cui G, Tani-Ichi S, Ogawa M, Abe S, Okazaki F, Kitano S, Miyachi H, Yamada H, Hara T, Yoshikai Y, Nagasawa T, Schütz G, Ikuta K.
- Journal Title
  
  Immunity
  
  Volume: 48 Issue: 2 Pages: 286-298
- DOI
  10.1016/j.immuni.2018.01.004
- NAID
  120006401712
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08835, KAKENHI-PLANNED-16H06496, KAKENHI-PUBLICLY-17H05643, KAKENHI-PROJECT-16H05172, KAKENHI-PROJECT-16K15288, KAKENHI-PROJECT-17K15721
[Journal Article] 多能造血前駆細胞からリンパ球までの分化を方向付ける骨髄IL-7ニッチの同定2017
- Author(s)
  原崇裕
- Journal Title
  
  医学のあゆみ
  
  Volume: 261 Pages: 1060-1064
- Data Source
  KAKENHI-PROJECT-16K08835
[Journal Article] Hematopoietic stem cell niches produce lineage-instructive signals to control multipotent progenitor differentiation2016
- Author(s)
  Gomes, A. C., Hara, T., Lim, V. Y., Herndler-Brandstetter, D., Nevius, E., Sugiyama, T., Tani-ichi, S., Schlenner, S., Richie, E., Rodewald, H., Flavell, R. A., Nagasawa, T., Ikuta, K., and Pereira, J. P.
- Journal Title
  
  Immunity
  
  Volume: 45 Issue: 6 Pages: 1219-1231
- DOI
  10.1016/j.immuni.2016.11.004
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01153, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111003, KAKENHI-PROJECT-16H05172, KAKENHI-PROJECT-16K08835, KAKENHI-PROJECT-16K15288
[Journal Article] Thy-1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation2016
- Author(s)
  Shinoda, K., Hirahara, K., Iinuma, T., Ichikawa, T., Suzuki, A., Sugaya, K., Tumes, D. J., Yamamoto, H., Hara, T., Tani-ichi, S., Ikuta, K., Okamoto, Y., and Nakayama, T.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA.
  
  Volume: ?
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460589
[Journal Article] STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus.2015
- Author(s)
  Wagatsuma K, Tani-Ichi S, Liang B, Shitara S, Ishihara K, Abe M, Miyachi H, Kitano S, Hara T, Nanno M, Ishikawa H, Sakimura K, Nakao M, Kimura H, Ikuta K.
- Journal Title
  
  J Immunol.
  
  Volume: 195 Issue: 4 Pages: 1804-14
- DOI
  10.4049/jimmunol.1302456
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350979, KAKENHI-PROJECT-26460572, KAKENHI-PROJECT-15K21083, KAKENHI-PUBLICLY-15H01153, KAKENHI-PLANNED-25116005, KAKENHI-PROJECT-25460589, KAKENHI-PROJECT-26640007, KAKENHI-PROJECT-26860322
[Journal Article] Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma.2015
- Author(s)
  Adachi T, Kobayashi T, Sugihara E, Yamada T, Ikuta K, Pittaluga S, Saya H, Amagai M, Nagao K.
- Journal Title
  
  Nature Med.
  
  Volume: 21 Issue: 11 Pages: 1272-1279
- DOI
  10.1038/nm.3962
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06840, KAKENHI-PUBLICLY-15H01153, KAKENHI-PROJECT-26253065, KAKENHI-PROJECT-25460589, KAKENHI-PROJECT-15K14384
[Journal Article] An Enhancer of the IL-7 Receptor α-Chain Locus Controls IL-7 Receptor Expression and Maintenance of Peripheral T Cells.2015
- Author(s)
  Abe A, Tani-ichi S, Shitara S, Cui G, Yamada H, Miyachi H, Kitano S, Hara T, Abe R, Yoshikai Y, Ikuta K.
- Journal Title
  
  J. Immunol.
  
  Volume: 195 Issue: 7 Pages: 3129-3138
- DOI
  10.4049/jimmunol.1302447
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06843, KAKENHI-PUBLICLY-15H01153, KAKENHI-PROJECT-15F15114, KAKENHI-PROJECT-25460589, KAKENHI-PROJECT-26860322
[Journal Article] Environments of B cell development2014
- Author(s)
  Tsuneto M, Kajikhina E, Seiler K, Reimer A, Tornack J, Bouquet C, Simmons S, Knoll M, Wolf I, Tokoyoda K, Hauser A, Hara T, Tani-ichi S, Ikuta K, Grün JR, Grützkau A, Engels N, Wienands J, Yanagisawa Y, Ohnishi K, Melchers F.
- Journal Title
  
  Immunology and Cell Biology
  
  Volume: 160 Issue: 2 Pages: 109-112
- DOI
  10.1016/j.imlet.2014.05.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860322
[Journal Article] Characterization of the interleukin-15 niche in primary and secondary lymphoid organs in vivo.2014
- Author(s)
  Cui G, Hara T, Simmons S, Wagatsuma K, Abe A, Miyachi H, Kitano S, Ishii M, Tani-ichi S, Ikuta K.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 111 Issue: 5 Pages: 1915-1920
- DOI
  10.1073/pnas.1318281111
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-24790468, KAKENHI-PUBLICLY-25111504, KAKENHI-PROJECT-25460589, KAKENHI-PROJECT-26860322
[Journal Article] Environments of B cell development.2014
- Author(s)
  Tsuneto M, Kajikhina E, Seiler K, Reimer A, Tornack J, Bouquet C, Simmons S, Knoll M, Wolf I, Tokoyoda K, Hauser A, Hara T, Tani-Ichi S, Ikuta K, Grun J. R, Grutzkau A, Engels N, Wienands J, Yanagisawa Y, Ohnishi K , Melchers F.
- Journal Title
  
  Immunol Lett.
  
  Volume: 157 Issue: 1-2 Pages: 60-63
- DOI
  10.1016/j.imlet.2013.11.011
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PUBLICLY-25111504, KAKENHI-PROJECT-25460589
[Journal Article] CD49b-dependent estabhshment of T helper cell memory.2013
- Author(s)
  Hanazawa, A., Hayashizaki, K.,Shinoda, K., Yagita, H., Okumura, K., Löhning, M., Hara, T., Tani-ichi, S., Ikuta, K., Eckes, B.,Radbruch, A., Tokoyoda, K, and Nakayama, T.
- Journal Title
  
  Immuno1. Cell Bio1
  
  Volume: 91 Issue: 8 Pages: 524-531
- DOI
  10.1038/icb.2013.36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J02883, KAKENHI-PROJECT-23390260, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-24790468, KAKENHI-PROJECT-24790469, KAKENHI-PUBLICLY-25111504, KAKENHI-PROJECT-25460589, KAKENHI-PROJECT-25860352
[Journal Article] Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations.2013
- Author(s)
  Tani-Ichi, S., Shimba, A., Wagatsuma, K., Miyachi, H., Kitano, S., Imai, K., Hara, T., and Ikuta, K.
- Journal Title
  
  Proc. Natl. Acad. Sci. U.S.A.
  
  Volume: 110 Issue: 2 Pages: 612-617
- DOI
  10.1073/pnas.1219242110
- NAID
  120005241695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659202, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-24790468, KAKENHI-PROJECT-24790469
[Journal Article] Interleukin-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes.2013
- Author(s)
  Shitara S, Hara T, Liang B, Wagatsuma K, Zuklys S, Hollander GA, Nakase H, Chiba T, Tani-ichi S, Ikuta K.
- Journal Title
  
  J Immunol
  
  Volume: 190 Issue: 12 Pages: 6173-6179
- DOI
  10.4049/jimmunol.1202573
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-24790468, KAKENHI-PROJECT-24790469, KAKENHI-PUBLICLY-25111504, KAKENHI-PROJECT-25460589
[Journal Article] IL-7産生細胞のリンパ組織内分布2013
- Author(s)
  原崇裕、生田宏一
- Journal Title
  
  医学のあゆみ
  
  Volume: Vol.246、No.12
- Data Source
  KAKENHI-PROJECT-24790468
[Journal Article] B cell progenitors and precursors change their microenvironment in fetal liver during early development.2013
- Author(s)
  Tsuneto M, Tokoyoda K, Kajikhina E, Hauser AE, Hara T, Tani-ichi S, Ikuta K, Melchers F.
- Journal Title
  
  Stem Cells
  
  Volume: 31 Issue: 12 Pages: 2800-2812
- DOI
  10.1002/stem.1421
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-24790468, KAKENHI-PROJECT-24790469, KAKENHI-PUBLICLY-25111504, KAKENHI-PROJECT-25460589
[Journal Article] Role of hepatocyte-derived IL-7 in maintenance of intrahepatic NKT cells and T cells and development of B cells in fetal liver.2012
- Author(s)
  Liang, B., T. Hara, K. Wagatsuma, J. Zhang, K. Maki, H. Miyachi, S. Kitano, C. Yabe-Nishimura, S. Tani-Ichi, and K. Ikuta
- Journal Title
  
  Journal of Immunology
  
  Volume: 189 Issue: 9 Pages: 4444-4450
- DOI
  10.4049/jimmunol.1201181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659202, KAKENHI-PROJECT-24790468, KAKENHI-PROJECT-24790469
[Journal Article] Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice.2012
- Author(s)
  Hara, T., S. Shitara, K. Imai, H. Miyachi, S. Kitano, H. Yao, S. Tani-Ichi, and K. Ikuta
- Journal Title
  
  Journal of Immunology
  
  Volume: 189 Issue: 4 Pages: 1577-1584
- DOI
  10.4049/jimmunol.1200586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659202, KAKENHI-PROJECT-24790468
[Journal Article] Upregulated IL-7Rα expression on colitogenic memory CD4^+ T cells may participate in the development and persistence of chronic colitis2011
- Author(s)
  Shinohara, T., Nemoto, Y., Kanai, T., Kameyama, K., Okamoto, R., Tsuchiya, K., Nakamura, T., Totsuka, T., Ikuta, K., Watanabe, M.
- Journal Title
  
  Journal of Immunology
  
  Volume: 186 Pages: 2623-2632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590531
[Journal Article] Upregulated IL-7Rα expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis2011
- Author(s)
  Shinohara, T., et al
- Journal Title
  
  J.Immunol.
  
  Volume: 186 Issue: 4 Pages: 2623-2632
- DOI
  10.4049/jimmunol.1000057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590531, KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23659394
[Journal Article] Essential role of interleukin-17A in the formation of a mycobacterial infection-induced granuloma in the lung2010
- Author(s)
  Okamoto Yoshida, Y., Umemura, M., Yahagi, A., O Brien, R.L., Ikuta, K., Kishihara, K., Hara, H., Nakae, S., Iwakura, Y., Matsuzaki, G.
- Journal Title
  
  Journal of Immunology
  
  Volume: 184 Pages: 4414-4422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590531
[Presentation] Identification of the gut microenvironment by the cytokine reporter mice2021
- Author(s)
  Hara T
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07604
[Presentation] The cytokine-producing immune microenvironment for innate lymphocytes2019
- Author(s)
  Koichi Ikuta, Guangwei Cui, Shinya Abe, Takuma Asahi, Takahiro Hara
- Organizer
  第48回　日本免疫学会学術集会（アクトシティ浜松）
- Data Source
  KAKENHI-PROJECT-19K07604
[Presentation] Estrogens suppress T cell production by a TEC-dependent mechanism2019
- Author(s)
  Shinya Abe, Aki Ejima, Akihiro Shimba, Mizuki Mori, Guangwei Cui, Takuma Asahi, Daichi Takami, Takahiro Hara, Shizue Tani-ichi, Koichi Ikuta
- Organizer
  第48回　日本免疫学会学術集会（アクトシティ浜松）
- Data Source
  KAKENHI-PROJECT-19K07604
[Presentation] Role of local IL-7 in maintenance of lung ILC2s2019
- Author(s)
  Daichi Takami, Shinya Abe, Akihiro Shimba, Takuma Asahi, Yuanbo Zhu, Aki Ejima, Shizue Tani-ichi, Takahiro Hara, Guangwei Cui, Koichi Ikuta
- Organizer
  第48回　日本免疫学会学術集会（アクトシティ浜松）
- Data Source
  KAKENHI-PROJECT-19K07604
[Presentation] NK細胞の分化を支持するIL-15産生性骨髄微小環境の解明2019
- Author(s)
  阿部真也、原崇裕、崔広為、生田宏一
- Organizer
  第29回　Kyoto T Cell Conference（芝蘭会館）
- Data Source
  KAKENHI-PROJECT-19K07604
[Presentation] Function of IL-7Rα in regulatory T cells2019
- Author(s)
  Shizue Tani-ichi, Hisa Mukohira, Takahiro Hara, Koichi Ikuta
- Organizer
  第48回　日本免疫学会学術集会（アクトシティ浜松）
- Data Source
  KAKENHI-PROJECT-19K07604
[Presentation] Intestinal epithelial cell-derived IL-15 supports the homeostasis of intraepithelial lymphocytes2018
- Author(s)
  Yuanbo Zhu, Guangwei Cui, Akihiro Shimba, Shinya Abe, Takahiro Hara, Shizue Tani-ichi, Koichi Ikuta
- Organizer
  日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K08835
[Presentation] Hematopoietic cell-derived IL-15 supports the development and maintenance of NK, NKT and memory CD8 T cells in bone marrow2018
- Author(s)
  Shinya Abe, Takahiro Hara, Guangwei Cui, Takuma Asahi, Koichi Ikuta
- Organizer
  日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K08835
[Presentation] CXCL12-expressing bone marrow stromal cells express adiponectin and are targeted by Adipoq-Cre transgene2018
- Author(s)
  Hisa Mukohira, Takahiro Hara, Shizue Tani-ichi, Koichi Ikuta
- Organizer
  日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K08835
[Presentation] Local IL-15 dependency of liver-resident ILC12018
- Author(s)
  Takuma Asahi, Akihiro Shimba, Guangwei Cui, Shinya Abe, Yuanbo Zhu, Aki Ejima, Daichi Takami, Shizue Tani-ichi, Takahiro Hara, Koichi Ikuta
- Organizer
  日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K08835
[Presentation] Identification of bone marrow IL-7 niche critical for B lymphopoiesis2017
- Author(s)
  Hara T and Ikuta K
- Organizer
  The 7th International Workshop of Kyoto T Cell Conference
- Place of Presentation
  京都大学芝蘭会館（京都府・京都市）
- Year and Date
  2017-03-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08835
[Presentation] Identification and characterization of IL-7 niche in vivo2017
- Author(s)
  Hara T and Ikuta K
- Organizer
  The 11th International Symposium of the Institute Network
- Place of Presentation
  藤井節郎記念医科学センター（徳島県・徳島市）
- Year and Date
  2017-01-26
- Data Source
  KAKENHI-PROJECT-16K08835
[Presentation] Identification of IL-15 niche for NK cells in bone marrow2016
- Author(s)
  阿部真也、原崇裕、崔広為、生田宏一
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県・宜野湾市）
- Year and Date
  2016-12-07
- Data Source
  KAKENHI-PROJECT-16K08835
[Presentation] 骨髄におけるリンパ球分化を制御するIL-7産生ストローマ細胞の同定2016
- Author(s)
  原崇裕、生田宏一
- Organizer
  第26回Kyoto T Cell Conference
- Place of Presentation
  延暦寺会館（滋賀県・大津市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-16K08835
[Presentation] Identification of IL-7 and IL-15 niche in lymphoid organs2015
- Author(s)
  HARA Takahiro
- Organizer
  The 56th Annual Meeting and International Symposium of Korean Society of Life Science
- Place of Presentation
  韓国、changwon convention center
- Year and Date
  2015-08-27
- Invited
- Data Source
  KAKENHI-PROJECT-26860322
[Presentation] Identification and characterization of IL-7 niche in gut-associated lymphoid tissue2015
- Author(s)
  原崇裕、生田宏一
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25460589
[Presentation] Differential roles of IL-7 and IL-2 receptor signals in lymphocyte differentiation and development revealed by IL-7Rα/IL-2Rβ chimera knock-in mice2015
- Author(s)
  榛葉旭恒、谷一靖江、増田喬子、崔広為、小川真、阿部真也、原崇裕、河本宏、生田宏一
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25460589
[Presentation] Identification and characterization of IL-7 niche in gut-associated lymphoid tissues2015
- Author(s)
  HARA Takahiro, IKUTA Kooichi
- Organizer
  第44回　日本免疫学会総会・学術集会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26860322
[Presentation] STAT5 and PI3K signals of the IL-7R play differential roles in T cell development and homeostasis revealed by novel IL-7Rα mutant mice2015
- Author(s)
  崔広為、榛葉旭恒、谷一靖江、小川真、阿部真也、原崇裕、生田宏一
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25460589
[Presentation] Characterization of the IL-15 niche in vivo2015
- Author(s)
  Cui, G., Hara, T., Simmons, S., Ishii, M., Tani-ichi, S., Ikuta, K.
- Organizer
  The 6th FIMSA Congress
- Place of Presentation
  Singapore
- Year and Date
  2015-07-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460589
[Presentation] Distribution and function of IL-7- and IL-15-expressing cells in intestines2014
- Author(s)
  原崇裕、崔広為、生田宏一
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-25460589
[Presentation] Distribution and function of IL-7- and IL-15-expressing cells in intestines2014
- Author(s)
  HARA Takahiro, CUI Guangwei, IKUTA Koichi
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-26860322
[Presentation] Differential roles of IL-7 and IL-2 receptor signals in lymphocyte development and maintenance revealed by IL-7Rα/IL-2Rβ chimera knock-in mice2014
- Author(s)
  榛葉旭恒、谷一靖江、増田喬子、原崇裕、河本宏、生田宏一
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10
- Data Source
  KAKENHI-PROJECT-25460589
[Presentation] Visualization and characterization of IL-7- and IL-15-expressing cells in vivo2013
- Author(s)
  Takahiro Hara, Guangwei Cui, and Koichi Ikuta
- Organizer
  International Workshop of Kyoto T Cell Conference 2013
- Place of Presentation
  京都大学芝蘭会館
- Data Source
  KAKENHI-PROJECT-24790468
[Presentation] Visualizing the immune microenvironment by reporter mice2013
- Author(s)
  Ikuta, K., Cui, G., Shitara, S., Liang, B., Tani-ichi, S., and Hara, T.
- Organizer
  The 20th East Asia Joint Symposium on Global Medical Science for the 22th Century
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-25460589
[Presentation] Visualization and characterization of IL-7- and IL-15-expressing cells in vivo2013
- Author(s)
  Hara, T., Cui, G., Shitara, S., Tani-ichi, S. and Ikuta, K.
- Organizer
  The 6th International Workshop of Kyoto T Cell Conference 2013
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-25460589
[Presentation] Distribution and function of IL-7-expressing cells in intestines2013
- Author(s)
  Takahiro Hara, Guangwei Cui, Soichiro Shitara, and Koichi Ikuta
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ
- Year and Date
  2013-12-11
- Data Source
  KAKENHI-PROJECT-24790468
[Presentation] Distribution and function of IL-7-expressing cells in intestines2013
- Author(s)
  原崇裕、崔広為、設楽宗一朗、生田宏一
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-25460589
[Presentation] Distribution and function of IL-7-expressing cells in large intestine2013
- Author(s)
  Hara, T. and Ikuta, K.
- Organizer
  The 4th Workshop on Synthetic Immunology
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-25460589
[Presentation] Visualization and characterization of IL-7- and IL-15-expressing cells in vivo2013
- Author(s)
  Hara Takahiro, Cui Guangwei, Ikuta Koichi
- Organizer
  International Workshop of Kyoto T Cell Conference 2013
- Place of Presentation
  京都大学　芝蘭会館
- Data Source
  KAKENHI-PROJECT-24790468
[Presentation] Identification and characterization of the IL-15-expressing cells in vivo2013
- Author(s)
  Cui, G., Hara, T., Simmons, S., Wagatsuma, K., Tani-ichi, S., Ishii, M., and Ikuta, K.
- Organizer
  The 20th East Asia Joint Symposium on Global Medical Science for the 22th Century
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-25460589
[Presentation] Distribution and function of IL-7-expressing cells in the intestinal tissues2013
- Author(s)
  Hara, T. and Ikuta, K.
- Organizer
  The 8th International Symposium of the Institute Network
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-25460589
[Presentation] Visualization and Characterization of Homeostatic Cytokine Expressing Cells In Vivo2013
- Author(s)
  Hara Takahiro, Cui Guangwei, Ikuta Koichi
- Organizer
  6th International Workshop of Kyoto T Cell Conference
- Place of Presentation
  京都大学　芝蘭会館
- Data Source
  KAKENHI-PROJECT-24790468
[Presentation] Visualization of the immune microenvironment by reporter mice2013
- Author(s)
  Ikuta, K., Cui, G., Shitara, S., Liang, B., Tani-ichi, S., and Hara, T.
- Organizer
  The 6th International Workshop of Kyoto T Cell Conference 2013
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-25460589
[Presentation] DISTRIBUTION AND FUNCTION OF IL-7-EXPRESSING CELLS IN THE INTESTINAL TISSUES2012
- Author(s)
  Takahiro Hara, Koichi Ikuta
- Organizer
  The Third Workshop of Synthetic Immunology
- Place of Presentation
  京都大学　芝蘭会館
- Data Source
  KAKENHI-PROJECT-24790468
[Presentation] リンパ管内皮細胞が産生するIL-7は末梢T細胞の組織分布を制御する2011
- Author(s)
  原崇裕、生田宏一
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-21590531
[Presentation] 腸管上皮内γ δ T細胞は胸腺に由来する2011
- Author(s)
  設楽宗一朗、梁冰霏、原崇裕、我妻慶祐、生田宏一
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-21590531
[Presentation] 腸管上皮内γδT細胞は胸腺に由来する2011
- Author(s)
  設楽宗一朗、梁冰霏、原崇裕、我妻慶祐、生田宏一
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-21590531
[Presentation] 肝細胞が産生するIL-7は肝臓でのリンパ球の分化と維持を制御する2011
- Author(s)
  梁冰霏、原崇裕、我妻慶祐、設楽宗一朗、谷一靖江、生田宏一
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-21590531
[Presentation] Local function of IL-7 produced by thymic and epidermal epithelial cells2010
- Author(s)
  Liang, B., Hara, T., Tani-ichi, S., Ikuta, K.
- Organizer
  The 14th International Congress of Immunology
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21590531
[Presentation] Distribution of IL-7-expressing cells in lymphoid organs2010
- Author(s)
  Hara, T., Tani-ichi, S., Ikuta, K.
- Organizer
  The 14th International Congress of Immunology
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-21590531
[Presentation] Local function of IL-7produced by thymic and epidermal epithelial cells2010
- Author(s)
  Liang, B., Hara, T., Tani-ichi, S., and Ikuta, K.
- Organizer
  The 14^<th> International Congress of Immunology
- Place of Presentation
  Kobe
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21590531
[Presentation] Distribution of IL-7-expressing organs. International Congress of Immunology2010
- Author(s)
  Hara, T., Tani-ichi, S., and Ikuta, K
- Organizer
  The 14^<th> International Congress of Immunology
- Place of Presentation
  Kobe
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21590531
[Presentation] リンパ組織におけるIL-7産生細胞の分布と機能2009
- Author(s)
  生田宏一、原崇裕、梁冰霏、谷一靖江
- Organizer
  第32回日本分子生物学会年会ワークショップ
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21590531
[Presentation] リンパ組織におけるIL-7産生細胞の分布と機能2009
- Author(s)
  生田宏一、原崇裕、梁冰霏、谷一靖江
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21590531
[Presentation] 胸線上皮細胞が産生するIL-7の局所的役割2009
- Author(s)
  生田宏一、原崇裕、梁冰霏、谷一靖江
- Organizer
  第39回日本免疫学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21590531
[Presentation] DISTRIBUTION AND FUNCTION OF IL-7-EXPRESSING CELLS IN THE INTESTINAL TISSUES
- Author(s)
  Takahiro Hara, Koichi Ikuta
- Organizer
  第8回研究所ネットワーク国際シンポジウム
- Place of Presentation
  京都大学　芝蘭会館
- Data Source
  KAKENHI-PROJECT-24790468
[Presentation] Distribution and function of IL-7-expressing cells in intestines
- Author(s)
  HARA Takahiro, CUI Guangwei, SHITARA Soichiro, IKUTA Koichi
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-24790468
[Presentation] Distribution and function of IL-7-expressing cells in large intestine
- Author(s)
  Takahiro Hara, Koichi Ikuta
- Organizer
  The Fourth Workshop of Synthetic Immunology
- Place of Presentation
  京都大学　楽友会館
- Data Source
  KAKENHI-PROJECT-24790468

1. TANI-ICHI Shizue (50432331)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
2. IKUTA Koichi (90193177)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
3. IMAI Kumiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NAGASAWA Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. SUGIYAMA Tatsuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Pereira João Pedro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 宮地均

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 宮内栄治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 阿部学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 杉原英志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 安部良

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HARA Takahiro 原 崇裕

Research Projects

Research Products

Co-Researchers

骨微小環境による自然免疫ダイナミクスの制御機構Principal Investigator

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Identification of the bone microenvironment that constructs the innate immune systemPrincipal Investigator

Principal Investigator

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Review Section

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Analysis of immune microenvironment essential for ILC2 developmentPrincipal Investigator

Principal Investigator

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Analysis of IL-7 niche in bone marrowPrincipal Investigator

Principal Investigator

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Distribution and function of IL-15-producing cells in vivo

Principal Investigator

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Endothalial cell-derived IL-7 controls B cell development and peripheral T cell maintenancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Distribution and function of IL-7-producing cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 感染・炎症・免疫 第４３巻2014

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[Book] 医学のあゆみ Vol.2462013

Author(s)

Total Pages

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[Journal Article] The roles of IL-7 and IL-15 in niches for lymphocyte progenitors and immune cells in lymphoid organs2021

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[Journal Article] IL-7R-Dependent Phosphatidylinositol 3-Kinase Competes with the STAT5 Signal to Modulate T Cell Development and Homeostasis.2020

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[Journal Article] Innate-like CD27+CD45RBhigh γδ T Cells Require TCR Signaling for Homeostasis in Peripheral Lymphoid Organs.2020

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[Journal Article] Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene.2019

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NAID

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[Journal Article] Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intra-epithelial lymphocytes in the intestine2019

Author(s)

HARA Takahiro 原崇裕

[Book] 感染・炎症・免疫　第４３巻2014

[Book] 医学のあゆみ　Vol.2462013