NAKASHIMA Katsuhiko 中島克彦

Researcher Number	90528035
Affiliation (based on the past Project Information) *help	2015 – 2016: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2013 – 2014: 独立行政法人国立がん研究センター, 研究所, 研究員 2012: 東京大学, 大学院・医学系研究科, 助教 2011 – 2012: 東京大学, 医学(系)研究科(研究院), 助教 2009 – 2010: The University of Tokyo, 大学院・医学系研究科, 助教
Review Section/Research Field	Principal Investigator 膠原病・アレルギー・感染症内科学 / Collagenous pathology/Allergology / Tumor biology
Keywords	Principal Investigator シトルリン化 / エピジェネティクス / PAD4 / PADI4 / 造血幹細胞 / リウマチ学 / 血球分化 / リウマチ / ペプチジルアルギニンデイミナーゼ / 造血 / 炎症 / 癌 / 翻訳後修飾

タンパク質シトルリン化酵素PAD4による癌抑制機構の解析Principal Investigator
- Principal Investigator
  
  中島克彦
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan
Role of PAD4 for inflammatory diseases and neutrophil extracellular trapsPrincipal Investigator
- Principal Investigator
  
  Nakashima Katsuhiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  National Cancer Center Japan
Roleofrheumatoidarthritis-relatedproteinPAD4inhematopoiesisPrincipal Investigator
- Principal Investigator
  
  NAKASHIMA Katsuhiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
Physiological function of PAD4, a rheumatoid arthritis-related protein, and its molecular mechanisms.Principal Investigator
- Principal Investigator
  
  NAKASHIMA Katsuhiko
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo

All 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] 造血多能性細胞におけるタンパク質シトルリン化の役割2015
- Author(s)
  中島克彦
- Journal Title
  
  医学のあゆみ
  
  Volume: 255 Pages: 877-882
- Data Source
  KAKENHI-PROJECT-25461494
[Journal Article] Augmentation of invadopodia formation in temozolomide-resistant or adopted glioma is regulated by c-Jun terminal kinase-paxillin axis.2015
- Author(s)
  Ueno H, Tomiyama A, Yamaguchi H, Uekita T et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 468 Pages: 240-247
- DOI
  10.1016/j.bbrc.2015.10.122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06850, KAKENHI-PROJECT-25430126, KAKENHI-PROJECT-25461494, KAKENHI-PROJECT-26290043
[Journal Article] MafB promotes atherosclerosis by inhibiting foam-cell apoptosis.2014
- Author(s)
  Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonz P, Takahashi S
- Journal Title
  
  Nature Comminications
  
  Volume: 5 Pages: 1-14
- DOI
  10.1038/ncomms4147
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-21220009, KAKENHI-PROJECT-24390196, KAKENHI-PROJECT-24390230, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24591145, KAKENHI-PUBLICLY-25126701, KAKENHI-PROJECT-25253056, KAKENHI-PROJECT-25461494, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-26670448
[Journal Article] Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells2013
- Author(s)
  Arai, S., et al.
- Journal Title
  
  Cell Report
  
  Volume: 3 Pages: 1187-1198
- DOI
  10.1016/j.celrep.2013.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05522, KAKENHI-PROJECT-23390091, KAKENHI-PROJECT-23791107, KAKENHI-PROJECT-24249021, KAKENHI-PROJECT-24390196, KAKENHI-PROJECT-24659175, KAKENHI-PROJECT-25461494, KAKENHI-PROJECT-221S0001
[Journal Article] PAD4 regulates proliferation of haematopoietic multipotent cells by controlling c-Myc expression2013
- Author(s)
  Nakashima K, Arai1 S, Suzuki A, Nariai Y, Urano T, Nakayama M, Ohara O, Yamamura K, Yamamoto K, Miyazaki T.
- Journal Title
  
  Nature Comm.
  
  Volume: 4 Pages: 1836-1836
- DOI
  10.1038/ncomms2862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23791107, KAKENHI-PROJECT-25461494, KAKENHI-PROJECT-221S0001
[Journal Article] 機能的なリコンビナントAIMタンパク質の作製2012
- Author(s)
  大塲麻生、中島克彦、宮崎徹
- Journal Title
  
  生化学
  
  Volume: 第84巻 Pages: 588-591
- Data Source
  KAKENHI-PROJECT-23791107
[Journal Article] Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes2012
- Author(s)
  Iwamura Y, Mori M, Nakashima K, Mikami T, Murayama K, Arai S, Miyazaki T.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 422 Pages: 476-481
- DOI
  10.1016/j.bbrc.2012.05.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05522, KAKENHI-PROJECT-23791107, KAKENHI-PROJECT-24390196
[Journal Article] Small RNA-mediated regulation of iPS cell generation.2011
- Author(s)
  Zhonghan Li, Chao-shun Yang, Katsuhiko Nakashima, Tariq M Rana.
- Journal Title
  
  EMBO J. 30
  
  Pages: 823-834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790943
[Journal Article] Small RNA-mediated regulation of iPS cell generation.2011
- Author(s)
  Zhonghan Li, Chao-shun Yang, Katsuhiko Nakashima, Tariq M Rana
- Journal Title
  
  EMBO J.
  
  Volume: 30 Pages: 823-834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790943
[Journal Article] Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.2010
- Author(s)
  Jun Kurokawa, Satoko Arai, Katsuhiko Nakashima, Hiromichi Nagano, Akemi Nishijima, Keishi Miyata, Rui Ose, Mayumi Mori, Naoto Kubota, Takashi Kadowaki, Yuichi Oike, Hisashi Koga, Maria Febbraio, Toshihiko Iwanaga, Toru Miyazaki
- Journal Title
  
  Cell Metabolism
  
  Volume: 11 Pages: 479-492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790943
[Journal Article] The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability.2010
- Author(s)
  Nobuya Kurabe, Mayumi Mori, Jun Kurokawa, Kaori Taniguchi, Hisatoshi Aoyama, Kazuhiro Atsuda, Akemi Nishijima, Nariaki Odawara, Saori Harada, Katsuhiko Nakashima, Satoko Arai, Toru Miyazaki
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 391 Pages: 1708-1713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790943
[Journal Article] Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.2010
- Author(s)
  Jun Kurokawa, Satoko Arai, Katsuhiko Nakashima, Hiromichi Nagano, Akemi Nishijima, Keishi Miyata, Rui Ose, Mayumi Mori, Naoto Kubota, Takashi Kadowaki, Yuichi Oike, Hisashi Koga, Maria Febbraio, Toshihiko Iwanaga, Toru Miyazaki.
- Journal Title
  
  Cell Metabolism 11
  
  Pages: 479-492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790943
[Journal Article] The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability.2010
- Author(s)
  Nobuya Kurabe, Mayumi Mori, Jun Kurokawa, Kaori Taniguchi, Hisatoshi Aoyama, Kazuhiro Atsuda, Akemi Nishijima, Nariaki Odawara, Saori Harada, Katsuhiko Nakashima, Satoko Arai, Toru Miyazaki.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 391
  
  Pages: 1708-1713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790943
[Journal Article] Dynamic expression of peptidylarginine deiminase 2 in human monocytic leukemia THP-1 cells during macrophage differentiation.2009
- Author(s)
  Ikuko Hojo-Nakashima, Ryo Sato, Katsuhiko Nakashima (corresponding author), Teruki Hagiwara, Michiyuki Yamada.
- Journal Title
  
  J.Biochem. 146
  
  Pages: 471-479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790943
[Presentation] 膵臓がん細胞におけるSide-Population細胞の特性とその分子基盤2015
- Author(s)
  中島克彦、堺隆一
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25461494
[Presentation] Molecular characterization of side-population cells in pancreatic cancer cells2015
- Author(s)
  Katsuhiko Nakashima, Ryuichi Sakai
- Organizer
  Mechanisms and Models of Cancer
- Place of Presentation
  米国　サンディエゴ
- Year and Date
  2015-08-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461494
[Presentation] 血中AIM濃度を制御する医薬品開発のための、AIM-IgM複合体の結晶構造解析に向けて2013
- Author(s)
  甲斐敏裕、中島克彦、新井郷子、宮崎徹
- Organizer
  第８６回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25461494
[Presentation] PAD4regulatesproliferations of hematopoietic multipotent progenitors by directly controlling c-Mycexpression2012
- Author(s)
  Katsuhiko Nakashima, Satoko Arai, Toru Miyazaki
- Organizer
  99th AnnualMeeting,AmericanAssociationofImmunologists annual meeting
- Place of Presentation
  Hynes Convention Center, Boston Massachucetts,USA
- Data Source
  KAKENHI-PROJECT-23791107
[Presentation] PAD4はc-mycの発現を制御することにより造血多能性細胞の増殖を制御する2012
- Author(s)
  中島克彦、宮崎徹
- Organizer
  第８５回　日本生化学会大会
- Place of Presentation
  福岡県（福岡国際会議場）
- Data Source
  KAKENHI-PROJECT-23791107
[Presentation] PAD4はc-mycの発現を制御することにより造血多能性細胞の増殖を制御する2012
- Author(s)
  中島克彦、宮崎徹
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡県(福岡国際会議場)
- Data Source
  KAKENHI-PROJECT-23791107
[Presentation] The role of PAD4 in hematopoietic stem cells and its molecular mechanisms.2010
- Author(s)
  Katsuhiko Nakashima, Akari Suzuki, Takeshi Urano, Osamu Ohara, Kazuhiko Yamamoto, Toru Miyazaki.
- Organizer
  BMB2010
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21790943
[Presentation] The role of PAD4 in hematopoietic stem cells and its molecular mechanisms.2010
- Author(s)
  Katsuhiko Nakashima, Akari Suzuki, Takeshi Urano, Osamu Ohara, Kazuhiko Yamamoto, Toru Miyazaki.
- Organizer
  第33回に本分子生物学会年会・第83回日本生化学会年会合同大会
- Place of Presentation
  神戸ポートアイランド(兵庫)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21790943
[Presentation] AIMの翻訳後分子修飾の脂肪細胞における生理活性に対する意義2010
- Author(s)
  長野広通, 黒川淳, 中島克彦, 新井郷子, 宮崎徹
- Organizer
  第33回に本分子生物学会年会・第83回日本生化学会年会合同大会
- Place of Presentation
  神戸ポートアイランド(兵庫)
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21790943
[Presentation] リウマチ関連タンパク質PAD4の血球分化、機能への関与2009
- Author(s)
  中島克彦, 鈴木亜香里, 山本一彦, 宮崎徹
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(兵庫)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21790943
[Presentation] A new role of AIM, an apoptosis inhibitor expressed by macrophage, on adipocytes.2009
- Author(s)
  黒川淳, 新井郷子, 中島克彦, 宮崎徹
- Organizer
  第32回に本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21790943
[Presentation] To identify the pathogenic T lymphocytes for metabolic syndrome.2009
- Author(s)
  谷口香織, 中島克彦, 新井郷子, 宮崎徹
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21790943
[Presentation] 肥満におけるアポトーシス抑制因子AIM/CD5Lの役割2009
- Author(s)
  黒川淳, 新井郷子, 中島克彦, 門脇孝, 岩永敏彦, 宮崎徹
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(兵庫)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21790943
[Presentation] リウマチ関連タンパク質PAD4の血球分化、機能への関与2009
- Author(s)
  中島克彦
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21790943
[Presentation] 膵臓がん細胞におけるSide-population細胞の特性
- Author(s)
  中島克彦、堺隆一
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25461494

1. SUZUKI Hiromu

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# of Collaborated Products: 1 results
2. MORIGUCHI Takashi

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# of Collaborated Products: 1 results
3. YAMAGUCHI Hideki

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# of Collaborated Products: 2 results
4. Tomiyama Arata

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5. 本多伸一郎

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6. 渋谷彰

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7. 新井郷子

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8. 森満

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9. 山村研一

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10. 山本一彦

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11. 鈴木登

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12. 鈴木貞夫

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13. 鈴木操

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14. 高橋智

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15. 宮崎徹

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16. 島野仁

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17. 阿部倫明

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18. 黒田悦史

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19. 上北尚正

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20. 堺隆一

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21. 白木原琢哉

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NAKASHIMA Katsuhiko 中島 克彦

Research Projects

Research Products

Co-Researchers

タンパク質シトルリン化酵素PAD4による癌抑制機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of PAD4 for inflammatory diseases and neutrophil extracellular trapsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roleofrheumatoidarthritis-relatedproteinPAD4inhematopoiesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Physiological function of PAD4, a rheumatoid arthritis-related protein, and its molecular mechanisms.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 造血多能性細胞におけるタンパク質シトルリン化の役割2015

Author(s)

Journal Title

Data Source

[Journal Article] Augmentation of invadopodia formation in temozolomide-resistant or adopted glioma is regulated by c-Jun terminal kinase-paxillin axis.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MafB promotes atherosclerosis by inhibiting foam-cell apoptosis.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PAD4 regulates proliferation of haematopoietic multipotent cells by controlling c-Myc expression2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 機能的なリコンビナントAIMタンパク質の作製2012

Author(s)

Journal Title

Data Source

[Journal Article] Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Small RNA-mediated regulation of iPS cell generation.2011

Author(s)

Journal Title

Data Source

[Journal Article] Small RNA-mediated regulation of iPS cell generation.2011

Author(s)

Journal Title

Data Source

[Journal Article] Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.2010

Author(s)

Journal Title

Data Source

[Journal Article] The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability.2010

Author(s)

Journal Title

Data Source

[Journal Article] Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.2010

Author(s)

Journal Title

NAKASHIMA Katsuhiko 中島克彦