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Hashimoto Hisayuki  橋本 寿之

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HASHIMOTO Hisayuki  橋本 寿之

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Researcher Number 90528390
Other IDs
Affiliation (Current) 2025: 慶應義塾大学, 医学部(信濃町), 特任講師
Affiliation (based on the past Project Information) *help 2022 – 2025: 慶應義塾大学, 医学部(信濃町), 特任講師
2019 – 2021: 慶應義塾大学, 医学部(信濃町), 助教
2012 – 2014: 慶應義塾大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 42030:Animal life science-related / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 53020:Cardiology-related / Pathological medical chemistry
Except Principal Investigator
Cardiovascular medicine
Keywords
Principal Investigator
再生医療 / 心臓発生 / 転写因子 / リプログラミング / 心筋分化 / 心不全 / 細胞移植 / 先天性心疾患 / 心筋再生 / ライブイメージング / 細胞周期 … More
Except Principal Investigator
… More iPS細胞を用いた疾患解析 / 疾患モデル / 疾患解析 / iPS細胞 / ミトコンドリア病 Less
  • Research Projects

    (6 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (12 People)
  •  細胞分化転換法を用いた臓器発生と疾患発症の分子機構解明Principal Investigator

    • Principal Investigator
      橋本 寿之
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Keio University
  •  細胞移植療法の最適化に向けた生体内移植細胞の非侵襲的検出技術の開発Principal Investigator

    • Principal Investigator
      橋本 寿之
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      Keio University
  •  Dissecting the transcriptional network of organogenesis based on reprogramming factorsPrincipal Investigator

    • Principal Investigator
      橋本 寿之
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Keio University
  •  Dissecting the cardiogenic network of ZNF281Principal Investigator

    • Principal Investigator
      Hashimoto Hisayuki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Keio University
  •  Disease Modeling for Mitochondrial Disease Using MELAS Specific Induced Pluripotent Stem Cells

    • Principal Investigator
      KODAIRA Masaki
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Keio University
  •  Exploring a novel cardiomyocyte cell cycle regulator by utilizing a fluorescent ubiquitination-based cell cycle indicatorPrincipal Investigator

    • Principal Investigator
      HASHIMOTO Hisayuki
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Keio University

All 2024 2023 2022 2021 2019 2015 2014 2013 Other

All Journal Article Presentation

  • [Journal Article] MEF2C/p300-mediated epigenetic remodeling promotes the maturation of?induced cardiomyocytes2023

    • Author(s)
      Kojima Hidenori、Sadahiro Taketaro、Muraoka Naoto、Yamakawa Hiroyuki、Hashimoto Hisayuki、Ishii Ryota、Gosho Masahiko、Abe Yuto、Yamada Yu、Nakano Koji、Honda Seiichiro、Fujita Ryo、Akiyama Tatsuya、Sunagawa Yoichi、Morimoto Tatsuya、Tsukahara Toshifumi、Hirai Hiroyuki、Fukuda Keiichi、Ieda Masaki
    • Journal Title

      Stem Cell Reports

      Volume: 18 Issue: 6 Pages: 1274-1283

    • DOI

      10.1016/j.stemcr.2023.05.001

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K17427, KAKENHI-PROJECT-21K19471, KAKENHI-PROJECT-23K18581, KAKENHI-PROJECT-21K08072, KAKENHI-PROJECT-21H02067, KAKENHI-PROJECT-23K23798, KAKENHI-PROJECT-23K24326
  • [Journal Article] Machine learning in cardiology: Clinical application and basic research2023

    • Author(s)
      Komuro Jin、Kusumoto Dai、Hashimoto Hisayuki、Yuasa Shinsuke
    • Journal Title

      Journal of Cardiology

      Volume: 82 Issue: 2 Pages: 128-133

    • DOI

      10.1016/j.jjcc.2023.04.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K18581, KAKENHI-PROJECT-23K23798
  • [Journal Article] Development of non-bias phenotypic drug screening for cardiomyocyte hypertrophy by image segmentation using deep learning2022

    • Author(s)
      Komuro Jin、Tokuoka Yuta、Seki Tomohisa、Kusumoto Dai、Hashimoto Hisayuki、Katsuki Toshiomi、Nakamura Takahiro、Akiba Yohei、Kuoka Thukaa、Kimura Mai、Yamada Takahiro、Fukuda Keiichi、Funahashi Akira、Yuasa Shinsuke
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 632 Pages: 181-188

    • DOI

      10.1016/j.bbrc.2022.09.108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03678, KAKENHI-PROJECT-23K23798
  • [Journal Article] The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure2022

    • Author(s)
      Shogo Ito, Hisayuki Hashimoto, Yoshikazu Kishino,Yoshihiro Fukumoto, Keiichi Fukuda, Shinsuke Yuasa, et al.
    • Journal Title

      Nature Communication

      Volume: 13 Issue: 1 Pages: 5409-5409

    • DOI

      10.1038/s41467-022-33152-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K08164, KAKENHI-PROJECT-20K17167, KAKENHI-PROJECT-20H03678, KAKENHI-PROJECT-20K17129, KAKENHI-PROJECT-23K23798
  • [Journal Article] The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming2021

    • Author(s)
      Garry Glynnis A.、Bezprozvannaya Svetlana、Chen Kenian、Zhou Huanyu、Hashimoto Hisayuki、Morales Maria Gabriela、Liu Ning、Bassel-Duby Rhonda、Olson Eric N.
    • Journal Title

      Nature Cell Biology

      Volume: 23 Issue: 5 Pages: 467-475

    • DOI

      10.1038/s41556-021-00668-z

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K17537
  • [Journal Article] Anti-senescent drug screening by deep learning-based morphology senescence scoring2021

    • Author(s)
      Kusumoto Dai、Seki Tomohisa、Sawada Hiromune、Kunitomi Akira、Katsuki Toshiomi、Kimura Mai、Ito Shogo、Komuro Jin、Hashimoto Hisayuki、Fukuda Keiichi、Yuasa Shinsuke
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 257-257

    • DOI

      10.1038/s41467-020-20213-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03678, KAKENHI-PROJECT-19K08549, KAKENHI-PROJECT-19K17537
  • [Journal Article] Impaired respiratory function in MELAS-induced pluripotent stem cells with high heteroplasmy levels2015

    • Author(s)
      Masaki Kodaira, Hideyuki Hatakeyama, Shinsuke Yuasa, Tomohisa Seki, Toru Egashira, Shugo Tohyama, Yusuke Kuroda, Atsushi Tanaka, Shinichiro Okata, Hisayuki Hashimoto, Dai Kusumoto, Akira Kunitomi, Makoto Takei, Shin Kashimura, Tomoyuki Suzuki, Nozomi Hayashiji, Yuki Saito, Yu-ichi Goto, Keiichi Fukuda
    • Journal Title

      FEBS Open Bio

      Volume: 5 Issue: 1 Pages: 219-225

    • DOI

      10.1016/j.fob.2015.03.008

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25860623
  • [Journal Article] Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte2014

    • Author(s)
      Hisayuki Hashimoto
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890227
  • [Journal Article] Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte.2014

    • Author(s)
      Hashimoto H, Yuasa S, Tabata H, Tohyama S, Hayashiji N, Hattori F, Muraoka N, Egashira T, Okata S, Yae K, Seki T, Nishiyama T, Nakajima K, Sakaue-Sawano A, Miyawaki A and Fukuda K.
    • Journal Title

      J.Mol. Cell. Cardiol.

      Volume: S0022-2828(14) Pages: 97-2

    • DOI

      10.1016/j.yjmcc.2014.03.020

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22111001, KAKENHI-PLANNED-22111004, KAKENHI-PROJECT-22240041, KAKENHI-PROJECT-24890227, KAKENHI-PUBLICLY-25123727, KAKENHI-PROJECT-25430046, KAKENHI-PROJECT-25860621, KAKENHI-PROJECT-26670408
  • [Presentation] Cardiac Reprogramming Inducer ZNF281 Orchestrates the Cardiac Lineage Network during Heart Development2024

    • Author(s)
      橋本寿之
    • Organizer
      第88回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K23798
  • [Presentation] Discovering a Novel Cardiogenic Network through Direct Cardiac Reprogramming2023

    • Author(s)
      橋本寿之
    • Organizer
      第7回日本循環器学会 基礎研究フォーラム(BCVR)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K23798
  • [Presentation] Cardiac Reprogramming Inducer ZNF281 is Indispensable for Heart Development by Interacting with Key Cardiac Transcriptional Factors2022

    • Author(s)
      Hisayuki Hashimoto
    • Organizer
      AHA Basic Cardiovascular Sciences Scientific Session 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K23798
  • [Presentation] Cell fate conversion by epigenome editing2021

    • Author(s)
      Hisayuki Hashimoto
    • Organizer
      Basic Cardiovascular Research Scientific Session
    • Data Source
      KAKENHI-PROJECT-19K17537
  • [Presentation] エピジェネティクス解析を用いた心筋リプログラミングの分子機構の解明2019

    • Author(s)
      橋本 寿之
    • Organizer
      日本循環制御医学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17537
  • [Presentation] A Novel Cardiac ex vivo Culture System Revealed the Elongation of Cell Cycle Phases in Cardiomyocytes During Development2013

    • Author(s)
      Hisayuki Hashimoto, Shinsuke Yuasa, Hidenori Tabata, Shugo Tohyama, Toru Egashira, Tomohisa Seki, Kazunori Nakajima, Keiichi Fukuda
    • Organizer
      第30回国際心臓研究学会日本部会総会
    • Place of Presentation
      米国・サンディエゴ
    • Year and Date
      2013-06-29
    • Data Source
      KAKENHI-PROJECT-24890227
  • [Presentation] A Novel Cardiac ex vivo Culture System Revealed the Elongation of Cell Cycle Phases in Cardiomyocytes During Development

    • Author(s)
      Hisayuki Hashimoto
    • Organizer
      International Society for Heart Research (ISHR) The 30 th Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-24890227
  • 1.  KODAIRA Masaki (70464865)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 2.  YUASA Shinsuke (90398628)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 3.  EGASHIRA Toru (10465023)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  KUSUMOTO Dai (70571727)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  KUNITOMI Akira (30570882)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  KASHIMURA Shin (90571125)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  木内 謙一郎 (50528578)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  家田 真樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  伊藤 章吾
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  岸野 喜一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  林 茂生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  仲嶋 一範
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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