Hashimoto Hisayuki 橋本寿之

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HASHIMOTO Hisayuki 橋本寿之

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Researcher Number	90528390
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 特任講師
Affiliation (based on the past Project Information) *help	2022 – 2025: 慶應義塾大学, 医学部(信濃町), 特任講師 2019 – 2021: 慶應義塾大学, 医学部(信濃町), 助教 2012 – 2014: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 42030:Animal life science-related / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 53020:Cardiology-related / Pathological medical chemistry Except Principal Investigator Cardiovascular medicine
Keywords	Principal Investigator 再生医療 / 心臓発生 / 転写因子 / リプログラミング / 心筋分化 / 心不全 / 細胞移植 / 先天性心疾患 / 心筋再生 / ライブイメージング / 細胞周期 … More Except Principal Investigator … More iPS細胞を用いた疾患解析 / 疾患モデル / 疾患解析 / iPS細胞 / ミトコンドリア病 Less

細胞分化転換法を用いた臓器発生と疾患発症の分子機構解明Principal Investigator
- Principal Investigator
  
  橋本寿之
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Keio University
細胞移植療法の最適化に向けた生体内移植細胞の非侵襲的検出技術の開発Principal Investigator
- Principal Investigator
  
  橋本寿之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Keio University
Dissecting the transcriptional network of organogenesis based on reprogramming factorsPrincipal Investigator
- Principal Investigator
  
  橋本寿之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Keio University
Dissecting the cardiogenic network of ZNF281Principal Investigator
- Principal Investigator
  
  Hashimoto Hisayuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Keio University
Disease Modeling for Mitochondrial Disease Using MELAS Specific Induced Pluripotent Stem Cells
- Principal Investigator
  
  KODAIRA Masaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Keio University
Exploring a novel cardiomyocyte cell cycle regulator by utilizing a fluorescent ubiquitination-based cell cycle indicatorPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Hisayuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University

All 2024 2023 2022 2021 2019 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] MEF2C/p300-mediated epigenetic remodeling promotes the maturation of?induced cardiomyocytes2023
- Author(s)
  Kojima Hidenori、Sadahiro Taketaro、Muraoka Naoto、Yamakawa Hiroyuki、Hashimoto Hisayuki、Ishii Ryota、Gosho Masahiko、Abe Yuto、Yamada Yu、Nakano Koji、Honda Seiichiro、Fujita Ryo、Akiyama Tatsuya、Sunagawa Yoichi、Morimoto Tatsuya、Tsukahara Toshifumi、Hirai Hiroyuki、Fukuda Keiichi、Ieda Masaki
- Journal Title
  
  Stem Cell Reports
  
  Volume: 18 Issue: 6 Pages: 1274-1283
- DOI
  10.1016/j.stemcr.2023.05.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K17427, KAKENHI-PROJECT-21K19471, KAKENHI-PROJECT-23K18581, KAKENHI-PROJECT-21K08072, KAKENHI-PROJECT-21H02067, KAKENHI-PROJECT-23K23798, KAKENHI-PROJECT-23K24326
[Journal Article] Machine learning in cardiology: Clinical application and basic research2023
- Author(s)
  Komuro Jin、Kusumoto Dai、Hashimoto Hisayuki、Yuasa Shinsuke
- Journal Title
  
  Journal of Cardiology
  
  Volume: 82 Issue: 2 Pages: 128-133
- DOI
  10.1016/j.jjcc.2023.04.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18581, KAKENHI-PROJECT-23K23798
[Journal Article] Development of non-bias phenotypic drug screening for cardiomyocyte hypertrophy by image segmentation using deep learning2022
- Author(s)
  Komuro Jin、Tokuoka Yuta、Seki Tomohisa、Kusumoto Dai、Hashimoto Hisayuki、Katsuki Toshiomi、Nakamura Takahiro、Akiba Yohei、Kuoka Thukaa、Kimura Mai、Yamada Takahiro、Fukuda Keiichi、Funahashi Akira、Yuasa Shinsuke
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 632 Pages: 181-188
- DOI
  10.1016/j.bbrc.2022.09.108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03678, KAKENHI-PROJECT-23K23798
[Journal Article] The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure2022
- Author(s)
  Shogo Ito, Hisayuki Hashimoto, Yoshikazu Kishino,Yoshihiro Fukumoto, Keiichi Fukuda, Shinsuke Yuasa, et al.
- Journal Title
  
  Nature Communication
  
  Volume: 13 Issue: 1 Pages: 5409-5409
- DOI
  10.1038/s41467-022-33152-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08164, KAKENHI-PROJECT-20K17167, KAKENHI-PROJECT-20H03678, KAKENHI-PROJECT-20K17129, KAKENHI-PROJECT-23K23798
[Journal Article] The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming2021
- Author(s)
  Garry Glynnis A.、Bezprozvannaya Svetlana、Chen Kenian、Zhou Huanyu、Hashimoto Hisayuki、Morales Maria Gabriela、Liu Ning、Bassel-Duby Rhonda、Olson Eric N.
- Journal Title
  
  Nature Cell Biology
  
  Volume: 23 Issue: 5 Pages: 467-475
- DOI
  10.1038/s41556-021-00668-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17537
[Journal Article] Anti-senescent drug screening by deep learning-based morphology senescence scoring2021
- Author(s)
  Kusumoto Dai、Seki Tomohisa、Sawada Hiromune、Kunitomi Akira、Katsuki Toshiomi、Kimura Mai、Ito Shogo、Komuro Jin、Hashimoto Hisayuki、Fukuda Keiichi、Yuasa Shinsuke
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 257-257
- DOI
  10.1038/s41467-020-20213-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03678, KAKENHI-PROJECT-19K08549, KAKENHI-PROJECT-19K17537
[Journal Article] Impaired respiratory function in MELAS-induced pluripotent stem cells with high heteroplasmy levels2015
- Author(s)
  Masaki Kodaira, Hideyuki Hatakeyama, Shinsuke Yuasa, Tomohisa Seki, Toru Egashira, Shugo Tohyama, Yusuke Kuroda, Atsushi Tanaka, Shinichiro Okata, Hisayuki Hashimoto, Dai Kusumoto, Akira Kunitomi, Makoto Takei, Shin Kashimura, Tomoyuki Suzuki, Nozomi Hayashiji, Yuki Saito, Yu-ichi Goto, Keiichi Fukuda
- Journal Title
  
  FEBS Open Bio
  
  Volume: 5 Issue: 1 Pages: 219-225
- DOI
  10.1016/j.fob.2015.03.008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860623
[Journal Article] Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte2014
- Author(s)
  Hisayuki Hashimoto
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890227
[Journal Article] Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte.2014
- Author(s)
  Hashimoto H, Yuasa S, Tabata H, Tohyama S, Hayashiji N, Hattori F, Muraoka N, Egashira T, Okata S, Yae K, Seki T, Nishiyama T, Nakajima K, Sakaue-Sawano A, Miyawaki A and Fukuda K.
- Journal Title
  
  J.Mol. Cell. Cardiol.
  
  Volume: S0022-2828(14) Pages: 97-2
- DOI
  10.1016/j.yjmcc.2014.03.020
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22111001, KAKENHI-PLANNED-22111004, KAKENHI-PROJECT-22240041, KAKENHI-PROJECT-24890227, KAKENHI-PUBLICLY-25123727, KAKENHI-PROJECT-25430046, KAKENHI-PROJECT-25860621, KAKENHI-PROJECT-26670408
[Presentation] Cardiac Reprogramming Inducer ZNF281 Orchestrates the Cardiac Lineage Network during Heart Development2024
- Author(s)
  橋本寿之
- Organizer
  第88回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-23K23798
[Presentation] Discovering a Novel Cardiogenic Network through Direct Cardiac Reprogramming2023
- Author(s)
  橋本寿之
- Organizer
  第7回日本循環器学会　基礎研究フォーラム（BCVR）
- Invited
- Data Source
  KAKENHI-PROJECT-23K23798
[Presentation] Cardiac Reprogramming Inducer ZNF281 is Indispensable for Heart Development by Interacting with Key Cardiac Transcriptional Factors2022
- Author(s)
  Hisayuki Hashimoto
- Organizer
  AHA Basic Cardiovascular Sciences Scientific Session 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23798
[Presentation] Cell fate conversion by epigenome editing2021
- Author(s)
  Hisayuki Hashimoto
- Organizer
  Basic Cardiovascular Research Scientific Session
- Data Source
  KAKENHI-PROJECT-19K17537
[Presentation] エピジェネティクス解析を用いた心筋リプログラミングの分子機構の解明2019
- Author(s)
  橋本　寿之
- Organizer
  日本循環制御医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17537
[Presentation] A Novel Cardiac ex vivo Culture System Revealed the Elongation of Cell Cycle Phases in Cardiomyocytes During Development2013
- Author(s)
  Hisayuki Hashimoto, Shinsuke Yuasa, Hidenori Tabata, Shugo Tohyama, Toru Egashira, Tomohisa Seki, Kazunori Nakajima, Keiichi Fukuda
- Organizer
  第30回国際心臓研究学会日本部会総会
- Place of Presentation
  米国・サンディエゴ
- Year and Date
  2013-06-29
- Data Source
  KAKENHI-PROJECT-24890227
[Presentation] A Novel Cardiac ex vivo Culture System Revealed the Elongation of Cell Cycle Phases in Cardiomyocytes During Development
- Author(s)
  Hisayuki Hashimoto
- Organizer
  International Society for Heart Research (ISHR) The 30 th Annual Meeting of the International Society for Heart Research Japanese Section
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-24890227

1. KODAIRA Masaki (70464865)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. YUASA Shinsuke (90398628)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. EGASHIRA Toru (10465023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. KUSUMOTO Dai (70571727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. KUNITOMI Akira (30570882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KASHIMURA Shin (90571125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 木内謙一郎 (50528578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 家田真樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 伊藤章吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 岸野喜一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 林茂生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 仲嶋一範

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hashimoto Hisayuki 橋本 寿之

HASHIMOTO Hisayuki 橋本 寿之

Research Projects

Research Products

Co-Researchers

細胞分化転換法を用いた臓器発生と疾患発症の分子機構解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞移植療法の最適化に向けた生体内移植細胞の非侵襲的検出技術の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dissecting the transcriptional network of organogenesis based on reprogramming factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dissecting the cardiogenic network of ZNF281Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Disease Modeling for Mitochondrial Disease Using MELAS Specific Induced Pluripotent Stem Cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploring a novel cardiomyocyte cell cycle regulator by utilizing a fluorescent ubiquitination-based cell cycle indicatorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] MEF2C/p300-mediated epigenetic remodeling promotes the maturation of?induced cardiomyocytes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Machine learning in cardiology: Clinical application and basic research2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of non-bias phenotypic drug screening for cardiomyocyte hypertrophy by image segmentation using deep learning2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-senescent drug screening by deep learning-based morphology senescence scoring2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impaired respiratory function in MELAS-induced pluripotent stem cells with high heteroplasmy levels2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte2014

Author(s)

Journal Title

Data Source

Hashimoto Hisayuki 橋本寿之

HASHIMOTO Hisayuki 橋本寿之