Hirayama Masatoshi 平山雅敏

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Masatoshi Hirayama 平山雅敏

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Researcher Number	90528473
Affiliation (Current)	2025: 福岡大学, 医学部, 教授 2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 慶應義塾大学, 医学部(信濃町), 講師 2022: 慶應義塾大学, 医学部(信濃町), 助教 2022: 慶應義塾大学, 医学部(信濃町), 専任講師 2020 – 2021: 東京歯科大学, 歯学部, 助教 2015: 慶應義塾大学, 医学部, 特任助教 2014: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 56060:Ophthalmology-related / Ophthalmology Except Principal Investigator Basic Section 56060:Ophthalmology-related
Keywords	Principal Investigator 再生医療 / 涙腺 / ドライアイ / 涙液 / 発生 / エキソソーム / シグナル伝達 / 細胞外小胞 / 発生学 / 再生医学 … More / 幹細胞 / 転写因子 / 合成mRNA / 分化誘導 / 涙腺再生 … More Except Principal Investigator マクロファージ / 骨髄移植 / 間葉系幹細胞 Less

Reguratory control of functional development of the lacrimal glandsPrincipal Investigator
- Principal Investigator
  
  平山雅敏
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Keio University
間葉系幹細胞（MSC）の生体内作用における新たな細胞極性化の証明
- Principal Investigator
  
  榛村重人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Keio University
A novel assessment for the lacrimal gland functional regeneratonPrincipal Investigator
- Principal Investigator
  
  Hirayama Masatoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Keio University
  Tokyo Dental College
Induction of the lacrimal gland cells from stem cells by the regulation of transcriptional factors expressionPrincipal Investigator
- Principal Investigator
  
  Masatoshi Hirayama
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Ophthalmology
- Research Institution
  Keio University

All 2023 2021 2015 Other

All Journal Article Presentation Patent

[Journal Article] Non-apoptotic regulated cell death in Fuchs endothelial corneal dystrophy2023
- Author(s)
  Sakakura Saki、Inagaki Emi、Sayano Tomoko、Yamazaki Risa、Fusaki Noemi、Hatou Shin、Hirayama Masatoshi、Tsubota Kazuo、Negishi Kazuno、Okano Hideyuki、Shimmura Shigeto
- Journal Title
  
  Regenerative Therapy
  
  Volume: 24 Pages: 592-601
- DOI
  10.1016/j.reth.2023.11.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K09050
[Journal Article] Artificial intelligence to estimate the tear film breakup time and diagnose dry eye disease2023
- Author(s)
  Shimizu Eisuke、Ishikawa Toshiki、Tanji Makoto、Agata Naomichi、Nakayama Shintaro、Nakahara Yo、Yokoiwa Ryota、Sato Shinri、Hanyuda Akiko、Ogawa Yoko、Hirayama Masatoshi、Tsubota Kazuo、Sato Yasunori、Shimazaki Jun、Negishi Kazuno
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1
- DOI
  10.1038/s41598-023-33021-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K09050
[Journal Article] A Comprehensive Assessment of Tear-Film-Oriented Diagnosis (TFOD) in a Dacryoadenectomy Dry Eye Model2023
- Author(s)
  Sakakura Saki、Inagaki Emi、Ochiai Yuichiro、Yamamoto Masatoshi、Takai Naofumi、Nagata Taeko、Higa Kazunari、Sato Yasunori、Toshida Hiroshi、Murat Dogru、Hirayama Masatoshi、Ogawa Yoko、Negishi Kazuno、Shimmura Shigeto
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 22 Pages: 16510-16510
- DOI
  10.3390/ijms242216510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K09050, KAKENHI-PROJECT-23K09068
[Journal Article] Cytokeratin expression in mouse lacrimal gland germ epithelium2015
- Author(s)
  Hirayama M, Liu Y, Kawakita T, Shimmura S, Tsubota K
- Journal Title
  
  Experimental Eye Research
  
  Volume: 146 Pages: 54-59
- DOI
  10.1016/j.exer.2015.11.020
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26893262
[Patent] ES細胞およびその他の幹細胞から、涙腺上皮細胞を誘導する方法2015
- Inventor(s)
  平山雅敏
- Industrial Property Rights Holder
  平山雅敏
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-062726
- Filing Date
  2015-03-25
- Data Source
  KAKENHI-PROJECT-26893262
[Presentation] Cellular senescence promotes meibomian gland dysfunction (MGD) in a chronic graft-vs-host disease (cGVHD) mouse model.2023
- Author(s)
  Sato S, Ogawa Y, Shimizu E, Hirayama M, Shimmura S, Negishi K, Tsubota K.
- Organizer
  The Association for Research in Vision and Ophthalmology annual meeting 2023 (ARVO). New Orleans. 23-26 April 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K09050
[Presentation] DNA damage and cell death in an in vitro model of Fuchs endothelial corneal dystrophy.2023
- Author(s)
  Sakakura S, Inagaki E, Sayano T, Sugai E, Yamazaki R, Fusaki N, Hatou S, Hirayama M, Negishi K, Tsubota K, Okano H, Shimmura S.
- Organizer
  International Society for Stem Cell Research (ISSCR) 2023, Boston. 14-17 June 2023.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K09050
[Presentation] 涙腺再生医療の未来2023
- Author(s)
  平山雅敏
- Organizer
  箱根ドライアイクラブ
- Invited
- Data Source
  KAKENHI-PROJECT-23K09050
[Presentation] 角膜上皮細胞における涙液エクソソームの生理学的機能の解析2021
- Author(s)
  平山雅敏、比嘉一成、島崎潤
- Organizer
  角膜カンファランス2021
- Data Source
  KAKENHI-PROJECT-20K09780
[Presentation] 転写因子調節によるヒト涙腺上皮細胞表現型の直接誘導.2015
- Author(s)
  平山雅敏、川北哲也、榛村重人、洪実、坪田一男.
- Organizer
  第119回日本眼科学会総会
- Place of Presentation
  ロイトン札幌(北海道札幌市)
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-26893262
[Presentation] Induction of Lacrimal Gland Epithelial Cell Phenotype from Human ES Cells by Defined Factors2015
- Author(s)
  Hirayama M, Kawakita T, Shimmura S, Minoru Ko MS, Tsubota K.
- Organizer
  Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
- Place of Presentation
  Denver, U.S.A.
- Year and Date
  2015-05-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893262
[Presentation] マウス涙腺原基におけるサイトケラチン発現の解析
- Author(s)
  平山雅敏、川北哲也、榛村重人、坪田一男
- Organizer
  第14回日本再生医療学会総会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2015-03-19 – 2015-03-21
- Data Source
  KAKENHI-PROJECT-26893262

1. 榛村重人 (00235780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 森川暁 (00424169)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 岡野栄之 (60160694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hirayama Masatoshi 平山 雅敏

Masatoshi Hirayama 平山 雅敏

Research Projects

Research Products

Co-Researchers

Reguratory control of functional development of the lacrimal glandsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

間葉系幹細胞（MSC）の生体内作用における新たな細胞極性化の証明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel assessment for the lacrimal gland functional regeneratonPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Induction of the lacrimal gland cells from stem cells by the regulation of transcriptional factors expressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Non-apoptotic regulated cell death in Fuchs endothelial corneal dystrophy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Artificial intelligence to estimate the tear film breakup time and diagnose dry eye disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Comprehensive Assessment of Tear-Film-Oriented Diagnosis (TFOD) in a Dacryoadenectomy Dry Eye Model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytokeratin expression in mouse lacrimal gland germ epithelium2015

Author(s)

Journal Title

DOI

Data Source

[Patent] ES細胞およびその他の幹細胞から、涙腺上皮細胞を誘導する方法2015

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] Cellular senescence promotes meibomian gland dysfunction (MGD) in a chronic graft-vs-host disease (cGVHD) mouse model.2023

Author(s)

Organizer

Data Source

[Presentation] DNA damage and cell death in an in vitro model of Fuchs endothelial corneal dystrophy.2023

Author(s)

Organizer

Data Source

[Presentation] 涙腺再生医療の未来2023

Author(s)

Organizer

Data Source

[Presentation] 角膜上皮細胞における涙液エクソソームの生理学的機能の解析2021

Author(s)

Organizer

Data Source

[Presentation] 転写因子調節によるヒト涙腺上皮細胞表現型の直接誘導.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Induction of Lacrimal Gland Epithelial Cell Phenotype from Human ES Cells by Defined Factors2015

Author(s)

Hirayama Masatoshi 平山雅敏

Masatoshi Hirayama 平山雅敏